#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01019	uniprotkb:P00797	intact:EBI-751728|uniprotkb:Q16358|uniprotkb:Q16359|uniprotkb:Q96F91|ensembl:ENSP00000355627	intact:EBI-715794|uniprotkb:Q6T5C2|uniprotkb:Q6FI38|ensembl:ENSP00000272190	psi-mi:angt_human(display_long)|uniprotkb:Serpin A8(gene name synonym)|uniprotkb:AGT(gene name)|psi-mi:AGT(display_short)|uniprotkb:SERPINA8(gene name synonym)	psi-mi:reni_human(display_long)|uniprotkb:Angiotensinogenase(gene name synonym)|uniprotkb:REN(gene name)|psi-mi:REN(display_short)	psi-mi:"MI:0435"(protease assay)	Zhou et al. (2010)	pubmed:20927107|doi:10.1038/nature09505|imex:IM-16271	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0465"(DIP)	intact:EBI-15882764|imex:IM-16271-1|dip:DIP-187386E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000020.1|dip:DIP-309N|ensembl:ENSG00000135744(gene)|ensembl:ENST00000366667(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001819"(positive regulation of cytokine production)|rcsb pdb:2JP8|rcsb pdb:2WXW|rcsb pdb:2X0B|rcsb pdb:3CK0|rcsb pdb:3WOO|rcsb pdb:3WOR|rcsb pdb:4AA1|rcsb pdb:4APH|rcsb pdb:4FYS|rcsb pdb:5E2Q|rcsb pdb:5M3X|rcsb pdb:5M3Y|rcsb pdb:5XJM|rcsb pdb:6I3F|rcsb pdb:6I3I|rcsb pdb:6JOD|rcsb pdb:6OS0|rcsb pdb:7C6A|reactome:R-HSA-1989781|reactome:R-HSA-2022377|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-418594|go:"GO:0001822"(kidney development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002016"(regulation of blood volume by renin-angiotensin)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003014"(renal system process)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048144"(fibroblast proliferation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051969"(regulation of transmission of nerve impulse)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070471"(uterine smooth muscle contraction)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:1902632"(positive regulation of membrane hyperpolarization)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0008306"(associative learning)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014873"(response to muscle activity involved in regulation of muscle adaptation)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031703"(type 2 angiotensin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034104"(negative regulation of tissue remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035106"(operant conditioning)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:1905010"(positive regulation of L-lysine import across plasma membrane)|go:"GO:1905589"(positive regulation of L-arginine import across plasma membrane)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR000227(Angiotensinogen)|interpro:IPR023795|interpro:IPR023796|interpro:IPR033834|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P01019|rcsb pdb:1N9U|rcsb pdb:1N9V	refseq:NP_000528.1|dip:DIP-59219N|ensembl:ENSG00000143839(gene)|ensembl:ENST00000272190(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001823"(mesonephros development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008233"(peptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035690"|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042756"(drinking behavior)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045177"(apical part of cell)|go:"GO:0048469"(cell maturation)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0051591"(response to cAMP)|go:"GO:0070305"(response to cGMP)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR012848(Propeptide, peptidase A1)|interpro:IPR021109|interpro:IPR033121|interpro:IPR034135|rcsb pdb:1BBS|rcsb pdb:1BIL|rcsb pdb:1BIM|rcsb pdb:1HRN|rcsb pdb:1RNE|rcsb pdb:2BKS|rcsb pdb:2BKT|rcsb pdb:2FS4|rcsb pdb:2G1O|rcsb pdb:2G1R|rcsb pdb:2G1S|rcsb pdb:2G1Y|rcsb pdb:2G20|rcsb pdb:2G21|rcsb pdb:2G22|rcsb pdb:2G24|rcsb pdb:2G26|rcsb pdb:2G27|rcsb pdb:2I4Q|rcsb pdb:2IKO|rcsb pdb:2IKU|rcsb pdb:2IL2|rcsb pdb:2REN|rcsb pdb:2V0Z|rcsb pdb:2V10|rcsb pdb:2V11|rcsb pdb:2V12|rcsb pdb:2V13|rcsb pdb:2V16|rcsb pdb:2G1N|rcsb pdb:2X0B|rcsb pdb:3D91|rcsb pdb:3G6Z|rcsb pdb:3G72|rcsb pdb:3GW5|rcsb pdb:3K1W|rcsb pdb:3KM4|rcsb pdb:3O9L|rcsb pdb:3OAD|rcsb pdb:3OAG|rcsb pdb:3OOT|rcsb pdb:3OQF|rcsb pdb:3OQK|rcsb pdb:3OWN|rcsb pdb:3Q3T|rcsb pdb:3Q4B|rcsb pdb:3Q5H|rcsb pdb:3SFC|rcsb pdb:3VCM|rcsb pdb:3VSW|rcsb pdb:3VSX|rcsb pdb:3VUC|rcsb pdb:3VYD|rcsb pdb:3VYE|rcsb pdb:3VYF|rcsb pdb:4AMT|rcsb pdb:4GJ5|rcsb pdb:4GJ6|rcsb pdb:4GJ7|rcsb pdb:4GJ8|rcsb pdb:4GJ9|rcsb pdb:4GJA|rcsb pdb:4GJB|rcsb pdb:4GJC|rcsb pdb:4GJD|rcsb pdb:4PYV|rcsb pdb:4Q1N|rcsb pdb:4RYC|rcsb pdb:4RYG|rcsb pdb:4RZ1|rcsb pdb:4S1G|rcsb pdb:4XX3|rcsb pdb:4XX4|rcsb pdb:5KOQ|rcsb pdb:5KOS|rcsb pdb:5KOT|rcsb pdb:5SXN|rcsb pdb:5SY2|rcsb pdb:5SY3|rcsb pdb:5SZ9|rcsb pdb:5T4S|rcsb pdb:5TMG|rcsb pdb:5TMK|rcsb pdb:5V8V|rcsb pdb:5VPM|rcsb pdb:5VRP|rcsb pdb:6I3F|reactome:R-HSA-2022377|rcsb pdb:3G70	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:tt2vGFrfLSJ+dIa11l402Vs/3S49606	rogid:TPV6qY0Qzn5x6QhghuszUyxWowc9606	rigid:94iCNFLIXVQXExy2k0ewTZbiBWs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01019	uniprotkb:P00797	intact:EBI-751728|uniprotkb:Q16358|uniprotkb:Q16359|uniprotkb:Q96F91|ensembl:ENSP00000355627	intact:EBI-715794|uniprotkb:Q6T5C2|uniprotkb:Q6FI38|ensembl:ENSP00000272190	psi-mi:angt_human(display_long)|uniprotkb:Serpin A8(gene name synonym)|uniprotkb:AGT(gene name)|psi-mi:AGT(display_short)|uniprotkb:SERPINA8(gene name synonym)	psi-mi:reni_human(display_long)|uniprotkb:Angiotensinogenase(gene name synonym)|uniprotkb:REN(gene name)|psi-mi:REN(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Zhou et al. (2010)	pubmed:20927107|doi:10.1038/nature09505|imex:IM-16271	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15882782|imex:IM-16271-2|dip:DIP-187386E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000020.1|dip:DIP-309N|ensembl:ENSG00000135744(gene)|ensembl:ENST00000366667(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001819"(positive regulation of cytokine production)|rcsb pdb:2JP8|rcsb pdb:2WXW|rcsb pdb:2X0B|rcsb pdb:3CK0|rcsb pdb:3WOO|rcsb pdb:3WOR|rcsb pdb:4AA1|rcsb pdb:4APH|rcsb pdb:4FYS|rcsb pdb:5E2Q|rcsb pdb:5M3X|rcsb pdb:5M3Y|rcsb pdb:5XJM|rcsb pdb:6I3F|rcsb pdb:6I3I|rcsb pdb:6JOD|rcsb pdb:6OS0|rcsb pdb:7C6A|reactome:R-HSA-1989781|reactome:R-HSA-2022377|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-418594|go:"GO:0001822"(kidney development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002016"(regulation of blood volume by renin-angiotensin)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003014"(renal system process)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048144"(fibroblast proliferation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051969"(regulation of transmission of nerve impulse)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070471"(uterine smooth muscle contraction)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:1902632"(positive regulation of membrane hyperpolarization)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0008306"(associative learning)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014873"(response to muscle activity involved in regulation of muscle adaptation)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031703"(type 2 angiotensin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034104"(negative regulation of tissue remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035106"(operant conditioning)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:1905010"(positive regulation of L-lysine import across plasma membrane)|go:"GO:1905589"(positive regulation of L-arginine import across plasma membrane)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR000227(Angiotensinogen)|interpro:IPR023795|interpro:IPR023796|interpro:IPR033834|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P01019|rcsb pdb:1N9U|rcsb pdb:1N9V	refseq:NP_000528.1|dip:DIP-59219N|ensembl:ENSG00000143839(gene)|ensembl:ENST00000272190(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001823"(mesonephros development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008233"(peptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035690"|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042756"(drinking behavior)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045177"(apical part of cell)|go:"GO:0048469"(cell maturation)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0051591"(response to cAMP)|go:"GO:0070305"(response to cGMP)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR012848(Propeptide, peptidase A1)|interpro:IPR021109|interpro:IPR033121|interpro:IPR034135|rcsb pdb:1BBS|rcsb pdb:1BIL|rcsb pdb:1BIM|rcsb pdb:1HRN|rcsb pdb:1RNE|rcsb pdb:2BKS|rcsb pdb:2BKT|rcsb pdb:2FS4|rcsb pdb:2G1O|rcsb pdb:2G1R|rcsb pdb:2G1S|rcsb pdb:2G1Y|rcsb pdb:2G20|rcsb pdb:2G21|rcsb pdb:2G22|rcsb pdb:2G24|rcsb pdb:2G26|rcsb pdb:2G27|rcsb pdb:2I4Q|rcsb pdb:2IKO|rcsb pdb:2IKU|rcsb pdb:2IL2|rcsb pdb:2REN|rcsb pdb:2V0Z|rcsb pdb:2V10|rcsb pdb:2V11|rcsb pdb:2V12|rcsb pdb:2V13|rcsb pdb:2V16|rcsb pdb:2G1N|rcsb pdb:2X0B|rcsb pdb:3D91|rcsb pdb:3G6Z|rcsb pdb:3G72|rcsb pdb:3GW5|rcsb pdb:3K1W|rcsb pdb:3KM4|rcsb pdb:3O9L|rcsb pdb:3OAD|rcsb pdb:3OAG|rcsb pdb:3OOT|rcsb pdb:3OQF|rcsb pdb:3OQK|rcsb pdb:3OWN|rcsb pdb:3Q3T|rcsb pdb:3Q4B|rcsb pdb:3Q5H|rcsb pdb:3SFC|rcsb pdb:3VCM|rcsb pdb:3VSW|rcsb pdb:3VSX|rcsb pdb:3VUC|rcsb pdb:3VYD|rcsb pdb:3VYE|rcsb pdb:3VYF|rcsb pdb:4AMT|rcsb pdb:4GJ5|rcsb pdb:4GJ6|rcsb pdb:4GJ7|rcsb pdb:4GJ8|rcsb pdb:4GJ9|rcsb pdb:4GJA|rcsb pdb:4GJB|rcsb pdb:4GJC|rcsb pdb:4GJD|rcsb pdb:4PYV|rcsb pdb:4Q1N|rcsb pdb:4RYC|rcsb pdb:4RYG|rcsb pdb:4RZ1|rcsb pdb:4S1G|rcsb pdb:4XX3|rcsb pdb:4XX4|rcsb pdb:5KOQ|rcsb pdb:5KOS|rcsb pdb:5KOT|rcsb pdb:5SXN|rcsb pdb:5SY2|rcsb pdb:5SY3|rcsb pdb:5SZ9|rcsb pdb:5T4S|rcsb pdb:5TMG|rcsb pdb:5TMK|rcsb pdb:5V8V|rcsb pdb:5VPM|rcsb pdb:5VRP|rcsb pdb:6I3F|reactome:R-HSA-2022377|rcsb pdb:3G70	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:tt2vGFrfLSJ+dIa11l402Vs/3S49606	rogid:TPV6qY0Qzn5x6QhghuszUyxWowc9606	rigid:94iCNFLIXVQXExy2k0ewTZbiBWs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)