#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P47027	uniprotkb:P53135	intact:EBI-25984|uniprotkb:Q05712|uniprotkb:D6VW94|ensemblfungi:YJL090C	intact:EBI-23925|uniprotkb:D6VU34|ensemblfungi:YGL113W	psi-mi:dpb11_yeast(display_long)|uniprotkb:DPB11(gene name)|psi-mi:DPB11(display_short)|uniprotkb:J0918(orf name)|uniprotkb:YJL090C(locus name)	psi-mi:sld3_yeast(display_long)|uniprotkb:SLD3(gene name)|psi-mi:SLD3(display_short)|uniprotkb:G2980(orf name)|uniprotkb:YGL113W(locus name)	psi-mi:"MI:0096"(pull down)	Lopez-Mosqueda et al. (2010)	pubmed:20865002|doi:10.1038/nature09377|imex:IM-16285	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15879678|imex:IM-16285-1|dip:DIP-187422E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003626|refseq:NP_012445.1|dip:DIP-5037N|ensemblfungi:YJL090C(gene)|ensemblfungi:YJL090C_mRNA(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000725"(recombinational repair)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007533"(mating type switching)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1902597"(positive regulation of DNA replication origin binding)|interpro:IPR001357(BRCT)|interpro:IPR036420	sgd:S000003081|refseq:NP_011402.3|dip:DIP-5481N|mint:P53135|ensemblfungi:YGL113W(gene)|ensemblfungi:YGL113W_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007049"(cell cycle)|go:"GO:0031261"(DNA replication preinitiation complex)|interpro:IPR013948(DNA replication regulator Sld3)|interpro:IPR041393|interpro:IPR042511|rcsb pdb:3WI3	psi-mi:"MI:0465"(dip)	crc64:79B3A9BC7815E440	crc64:6E59D0DB3C082C28	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:CYn2Q78DOL/+HPutAsKRuKofolE559292	rogid:1uxenWX3lYYMDUWr0mAE207XsHI559292	rigid:qAs64ZNbIttjeGQqTIH4VT+iG9E	false	tandem tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P22216	uniprotkb:P53135	intact:EBI-17843|uniprotkb:D6W3L5|uniprotkb:Q6B1S1|ensemblfungi:YPL153C	intact:EBI-23925|uniprotkb:D6VU34|ensemblfungi:YGL113W	psi-mi:rad53_yeast(display_long)|uniprotkb:RAD53(gene name)|psi-mi:RAD53(display_short)|uniprotkb:MEC2(gene name synonym)|uniprotkb:SAD1(gene name synonym)|uniprotkb:Serine-protein kinase 1(gene name synonym)|uniprotkb:SPK1(gene name synonym)|uniprotkb:P2588(orf name)|uniprotkb:YPL153C(locus name)|uniprotkb:CHEK2 homolog(gene name synonym)	psi-mi:sld3_yeast(display_long)|uniprotkb:SLD3(gene name)|psi-mi:SLD3(display_short)|uniprotkb:G2980(orf name)|uniprotkb:YGL113W(locus name)	psi-mi:"MI:0424"(protein kinase assay)	Lopez-Mosqueda et al. (2010)	pubmed:20865002|doi:10.1038/nature09377|imex:IM-16285	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15879701|imex:IM-16285-2|dip:DIP-187421E	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015172.1|sgd:S000006074|ensemblfungi:YPL153C(gene)|ensemblfungi:YPL153C_mRNA(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008104"(protein localization)|go:"GO:0009202"(deoxyribonucleoside triphosphate biosynthetic process)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901857"(positive regulation of cellular respiration)|interpro:IPR000253(Forkhead-associated)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016256(Serine/threonine-protein kinase RAD53)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:1DMZ|rcsb pdb:1FHQ|rcsb pdb:1FHR|rcsb pdb:1G3G|rcsb pdb:1G6G|rcsb pdb:1J4K|rcsb pdb:1J4L|rcsb pdb:1J4O|rcsb pdb:1J4P|rcsb pdb:1J4Q|rcsb pdb:1K2M|rcsb pdb:1K2N|rcsb pdb:1K3J|rcsb pdb:1K3N|rcsb pdb:1K3Q|rcsb pdb:1QU5|rcsb pdb:2A0T|rcsb pdb:2JQI|rcsb pdb:2JQL|rcsb pdb:2YGV|rcsb pdb:4PDP|rcsb pdb:4PDS|rcsb pdb:5T2F|rcsb pdb:5T2S|rcsb pdb:5XZV|rcsb pdb:5XZW|rcsb pdb:6C4U|dip:DIP-2322N|mint:P22216	sgd:S000003081|refseq:NP_011402.3|dip:DIP-5481N|mint:P53135|ensemblfungi:YGL113W(gene)|ensemblfungi:YGL113W_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007049"(cell cycle)|go:"GO:0031261"(DNA replication preinitiation complex)|interpro:IPR013948(DNA replication regulator Sld3)|interpro:IPR041393|interpro:IPR042511|rcsb pdb:3WI3	psi-mi:"MI:0465"(dip)	crc64:84A9612229CA72D1	crc64:6E59D0DB3C082C28	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:OU8gjvSvTtvDvk+en1y8hyEjFhI559292	rogid:1uxenWX3lYYMDUWr0mAE207XsHI559292	rigid:5d/RfRrOWgcFmqa877di/LVK63E	false	mutation disrupting interaction:227-227	binding-associated region:646-646,642-642,639-639,638-638,631-631,618-618,609-609,607-607,591-591,582-582,534-534,521-521,507-507,505-505,497-497,495-495,493-493,466-466,463-463,456-456,451-451,373-373,370-370,154-154,153-153|O-phospho-L-threonine:88-88|O-phospho-L-threonine:92-92|O-phospho-L-threonine:445-445|O-phospho-L-threonine:553-553|O-phospho-L-threonine:559-559|O-phospho-L-serine:548-548|O-phospho-L-serine:459-459|O-phospho-L-serine:479-479|O-phospho-L-serine:482-482|O-phospho-L-serine:514-514|O-phospho-L-serine:643-643|O-phospho-L-serine:653-653	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22216	uniprotkb:P53135	intact:EBI-17843|uniprotkb:D6W3L5|uniprotkb:Q6B1S1|ensemblfungi:YPL153C	intact:EBI-23925|uniprotkb:D6VU34|ensemblfungi:YGL113W	psi-mi:rad53_yeast(display_long)|uniprotkb:RAD53(gene name)|psi-mi:RAD53(display_short)|uniprotkb:MEC2(gene name synonym)|uniprotkb:SAD1(gene name synonym)|uniprotkb:Serine-protein kinase 1(gene name synonym)|uniprotkb:SPK1(gene name synonym)|uniprotkb:P2588(orf name)|uniprotkb:YPL153C(locus name)|uniprotkb:CHEK2 homolog(gene name synonym)	psi-mi:sld3_yeast(display_long)|uniprotkb:SLD3(gene name)|psi-mi:SLD3(display_short)|uniprotkb:G2980(orf name)|uniprotkb:YGL113W(locus name)	psi-mi:"MI:0424"(protein kinase assay)	Lopez-Mosqueda et al. (2010)	pubmed:20865002|doi:10.1038/nature09377|imex:IM-16285	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15879771|imex:IM-16285-3|dip:DIP-187421E	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015172.1|sgd:S000006074|ensemblfungi:YPL153C(gene)|ensemblfungi:YPL153C_mRNA(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008104"(protein localization)|go:"GO:0009202"(deoxyribonucleoside triphosphate biosynthetic process)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901857"(positive regulation of cellular respiration)|interpro:IPR000253(Forkhead-associated)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016256(Serine/threonine-protein kinase RAD53)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:1DMZ|rcsb pdb:1FHQ|rcsb pdb:1FHR|rcsb pdb:1G3G|rcsb pdb:1G6G|rcsb pdb:1J4K|rcsb pdb:1J4L|rcsb pdb:1J4O|rcsb pdb:1J4P|rcsb pdb:1J4Q|rcsb pdb:1K2M|rcsb pdb:1K2N|rcsb pdb:1K3J|rcsb pdb:1K3N|rcsb pdb:1K3Q|rcsb pdb:1QU5|rcsb pdb:2A0T|rcsb pdb:2JQI|rcsb pdb:2JQL|rcsb pdb:2YGV|rcsb pdb:4PDP|rcsb pdb:4PDS|rcsb pdb:5T2F|rcsb pdb:5T2S|rcsb pdb:5XZV|rcsb pdb:5XZW|rcsb pdb:6C4U|dip:DIP-2322N|mint:P22216	sgd:S000003081|refseq:NP_011402.3|dip:DIP-5481N|mint:P53135|ensemblfungi:YGL113W(gene)|ensemblfungi:YGL113W_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007049"(cell cycle)|go:"GO:0031261"(DNA replication preinitiation complex)|interpro:IPR013948(DNA replication regulator Sld3)|interpro:IPR041393|interpro:IPR042511|rcsb pdb:3WI3	psi-mi:"MI:0465"(dip)	crc64:84A9612229CA72D1	crc64:6E59D0DB3C082C28	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:OU8gjvSvTtvDvk+en1y8hyEjFhI559292	rogid:1uxenWX3lYYMDUWr0mAE207XsHI559292	rigid:5d/RfRrOWgcFmqa877di/LVK63E	false	mutation disrupting interaction:227-227	O-phospho-L-threonine:14-14|O-phospho-L-threonine:310-310|O-phospho-L-serine:421-421|O-phospho-L-serine:493-493|O-phospho-L-serine:497-497|O-phospho-L-serine:521-521|O-phospho-L-serine:514-514|O-phospho-L-serine:534-534|O-phospho-L-serine:618-618	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)