#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q12285 uniprotkb:Q12125 intact:EBI-34904|uniprotkb:D6W1V6|ensemblfungi:YOL111C intact:EBI-36940|uniprotkb:D6W2M2|ensemblfungi:YOR164C psi-mi:mdy2_yeast(display_long)|uniprotkb:MDY2(gene name)|psi-mi:MDY2(display_short)|uniprotkb:TMA24(gene name synonym)|uniprotkb:Mating-deficient protein 2(gene name synonym)|uniprotkb:Translation machinery-associated protein 24(gene name synonym)|uniprotkb:GET5(gene name synonym)|uniprotkb:Golgi to ER traffic protein 5(gene name synonym)|uniprotkb:YOL111C(locus name) psi-mi:get4_yeast(display_long)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:O3580(orf name)|uniprotkb:YOR164C(locus name)|uniprotkb:Guided entry of tail-anchored proteins 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16594728|imex:IM-26462-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014530.1|sgd:S000005471|mint:Q12285|dip:DIP-1982N|ensemblfungi:YOL111C(gene)|ensemblfungi:YOL111C_mRNA(transcript)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR031765|interpro:IPR040474|rcsb pdb:2LNZ|rcsb pdb:2LXA|rcsb pdb:2LXC|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:3VEJ|rcsb pdb:3ZDM|rcsb pdb:4A20|rcsb pdb:4ASW|rcsb pdb:4GOC|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK sgd:S000005690|refseq:NP_014807.3|mint:Q12125|dip:DIP-2005N|ensemblfungi:YOR164C(gene)|ensemblfungi:YOR164C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK - crc64:CE6FC4282E0E472C crc64:98AFFDB4EA51B40F comment:Interaction observed in GET3-/- cells. Additional chaperones, only identified as HSP70s, were also seen to have bound.|figure legend:Fig. 2A, Supp Fig 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/11/15 2017/11/15 rogid:lKhHoZ+UA1ZcX8TOoZMgJX+fzI0559292 rogid:t1xcIrahizw7d4/IGrx82rIEkOU559292 rigid:U7TbnpcLIg15IA2BnY3nVHyQlz4 false flag tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q12285 uniprotkb:Q12118 intact:EBI-34904|uniprotkb:D6W1V6|ensemblfungi:YOL111C intact:EBI-31784|uniprotkb:D6W273|ensemblfungi:YOR007C psi-mi:mdy2_yeast(display_long)|uniprotkb:MDY2(gene name)|psi-mi:MDY2(display_short)|uniprotkb:TMA24(gene name synonym)|uniprotkb:Mating-deficient protein 2(gene name synonym)|uniprotkb:Translation machinery-associated protein 24(gene name synonym)|uniprotkb:GET5(gene name synonym)|uniprotkb:Golgi to ER traffic protein 5(gene name synonym)|uniprotkb:YOL111C(locus name) psi-mi:sgt2_yeast(display_long)|uniprotkb:Viral protein U-binding protein(gene name synonym)|uniprotkb:SGT/UBP(gene name synonym)|uniprotkb:SGT2(gene name)|psi-mi:SGT2(display_short)|uniprotkb:UNF346(orf name)|uniprotkb:YOR007C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16594728|imex:IM-26462-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014530.1|sgd:S000005471|mint:Q12285|dip:DIP-1982N|ensemblfungi:YOL111C(gene)|ensemblfungi:YOL111C_mRNA(transcript)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR031765|interpro:IPR040474|rcsb pdb:2LNZ|rcsb pdb:2LXA|rcsb pdb:2LXC|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:3VEJ|rcsb pdb:3ZDM|rcsb pdb:4A20|rcsb pdb:4ASW|rcsb pdb:4GOC|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK refseq:NP_014649.1|sgd:S000005533|dip:DIP-1983N|mint:Q12118|ensemblfungi:YOR007C(gene)|ensemblfungi:YOR007C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072380"(TRC complex)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|rcsb pdb:2LXB|rcsb pdb:2LXC|rcsb pdb:3ZDM|rcsb pdb:4ASV|rcsb pdb:4ASW|rcsb pdb:5LYN|rcsb pdb:5LYP|reactome:R-SCE-9609523 - crc64:CE6FC4282E0E472C crc64:33539B74F742BD3C comment:Interaction observed in GET3-/- cells. Additional chaperones, only identified as HSP70s, were also seen to have bound.|figure legend:Fig. 2A, Supp Fig 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/11/15 2017/11/15 rogid:lKhHoZ+UA1ZcX8TOoZMgJX+fzI0559292 rogid:u4qztYWJIAVQOzZGnkLFnO3S2NA559292 rigid:U7TbnpcLIg15IA2BnY3nVHyQlz4 false flag tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q12285 uniprotkb:P31539 intact:EBI-34904|uniprotkb:D6W1V6|ensemblfungi:YOL111C intact:EBI-8050|uniprotkb:D6VXX8|ensemblfungi:YLL026W psi-mi:mdy2_yeast(display_long)|uniprotkb:MDY2(gene name)|psi-mi:MDY2(display_short)|uniprotkb:TMA24(gene name synonym)|uniprotkb:Mating-deficient protein 2(gene name synonym)|uniprotkb:Translation machinery-associated protein 24(gene name synonym)|uniprotkb:GET5(gene name synonym)|uniprotkb:Golgi to ER traffic protein 5(gene name synonym)|uniprotkb:YOL111C(locus name) psi-mi:hs104_yeast(display_long)|uniprotkb:HSP104(gene name)|psi-mi:HSP104(display_short)|uniprotkb:YLL026W(locus name)|uniprotkb:L0948(orf name)|uniprotkb:Protein aggregation-remodeling factor HSP104(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16594728|imex:IM-26462-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014530.1|sgd:S000005471|mint:Q12285|dip:DIP-1982N|ensemblfungi:YOL111C(gene)|ensemblfungi:YOL111C_mRNA(transcript)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR031765|interpro:IPR040474|rcsb pdb:2LNZ|rcsb pdb:2LXA|rcsb pdb:2LXC|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:3VEJ|rcsb pdb:3ZDM|rcsb pdb:4A20|rcsb pdb:4ASW|rcsb pdb:4GOC|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK sgd:S000003949|refseq:NP_013074.1|mint:P31539|dip:DIP-2252N|ensemblfungi:YLL026W(gene)|ensemblfungi:YLL026W_mRNA(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0042026"(protein refolding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043335"(protein unfolding)|go:"GO:0043531"(ADP binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070370"(cellular heat acclimation)|go:"GO:0070414"(trehalose metabolism in response to heat stress)|go:"GO:0072380"(TRC complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004176(Clp, N-terminal)|interpro:IPR018368|interpro:IPR019489|interpro:IPR027417|interpro:IPR028299|interpro:IPR036628|interpro:IPR041546|rcsb pdb:5KNE|rcsb pdb:5U2U|rcsb pdb:5VJH|rcsb pdb:5VY8|rcsb pdb:5VY9|rcsb pdb:5VYA|rcsb pdb:5WBW|rcsb pdb:6AHF|rcsb pdb:6AMN|rcsb pdb:6N8T|rcsb pdb:6N8V|rcsb pdb:6N8Z - crc64:CE6FC4282E0E472C crc64:4AD0E7E3AF98E318 comment:Interaction observed in GET3-/- cells. Additional chaperones, only identified as HSP70s, were also seen to have bound.|figure legend:Fig. 2A, Supp Fig 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/11/15 2017/11/15 rogid:lKhHoZ+UA1ZcX8TOoZMgJX+fzI0559292 rogid:rMl56qonOOODJUyLVkkWwUq8Cj4559292 rigid:U7TbnpcLIg15IA2BnY3nVHyQlz4 false flag tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q12285 uniprotkb:P38276 intact:EBI-34904|uniprotkb:D6W1V6|ensemblfungi:YOL111C intact:EBI-21630|uniprotkb:D6VQD3|ensemblfungi:YBR137W psi-mi:mdy2_yeast(display_long)|uniprotkb:MDY2(gene name)|psi-mi:MDY2(display_short)|uniprotkb:TMA24(gene name synonym)|uniprotkb:Mating-deficient protein 2(gene name synonym)|uniprotkb:Translation machinery-associated protein 24(gene name synonym)|uniprotkb:GET5(gene name synonym)|uniprotkb:Golgi to ER traffic protein 5(gene name synonym)|uniprotkb:YOL111C(locus name) psi-mi:yby7_yeast(display_long)|uniprotkb:YBR1013(orf name)|uniprotkb:YBR137W(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16594728|imex:IM-26462-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014530.1|sgd:S000005471|mint:Q12285|dip:DIP-1982N|ensemblfungi:YOL111C(gene)|ensemblfungi:YOL111C_mRNA(transcript)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR031765|interpro:IPR040474|rcsb pdb:2LNZ|rcsb pdb:2LXA|rcsb pdb:2LXC|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:3VEJ|rcsb pdb:3ZDM|rcsb pdb:4A20|rcsb pdb:4ASW|rcsb pdb:4GOC|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK refseq:NP_009695.2|sgd:S000000341|mint:P38276|dip:DIP-2038N|ensemblfungi:YBR137W(gene)|ensemblfungi:YBR137W_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR005624(Protein of unknown function DUF336)|interpro:IPR010371(Protein of unknown function DUF967)|interpro:IPR038084|rcsb pdb:4CLC - crc64:CE6FC4282E0E472C crc64:8CBA454492E29273 comment:Interaction observed in GET3-/- cells. Additional chaperones, only identified as HSP70s, were also seen to have bound.|figure legend:Fig. 2A, Supp Fig 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/11/15 2017/11/15 rogid:lKhHoZ+UA1ZcX8TOoZMgJX+fzI0559292 rogid:UsO9ZYVJXLI50JBd/g0C1NtSeXI559292 rigid:U7TbnpcLIg15IA2BnY3nVHyQlz4 false flag tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q12125 uniprotkb:Q12285 intact:EBI-36940|uniprotkb:D6W2M2|ensemblfungi:YOR164C intact:EBI-34904|uniprotkb:D6W1V6|ensemblfungi:YOL111C psi-mi:get4_yeast(display_long)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:O3580(orf name)|uniprotkb:YOR164C(locus name)|uniprotkb:Guided entry of tail-anchored proteins 4(gene name synonym) psi-mi:mdy2_yeast(display_long)|uniprotkb:MDY2(gene name)|psi-mi:MDY2(display_short)|uniprotkb:TMA24(gene name synonym)|uniprotkb:Mating-deficient protein 2(gene name synonym)|uniprotkb:Translation machinery-associated protein 24(gene name synonym)|uniprotkb:GET5(gene name synonym)|uniprotkb:Golgi to ER traffic protein 5(gene name synonym)|uniprotkb:YOL111C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16594741|imex:IM-26462-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000005690|refseq:NP_014807.3|mint:Q12125|dip:DIP-2005N|ensemblfungi:YOR164C(gene)|ensemblfungi:YOR164C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK refseq:NP_014530.1|sgd:S000005471|mint:Q12285|dip:DIP-1982N|ensemblfungi:YOL111C(gene)|ensemblfungi:YOL111C_mRNA(transcript)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR031765|interpro:IPR040474|rcsb pdb:2LNZ|rcsb pdb:2LXA|rcsb pdb:2LXC|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:3VEJ|rcsb pdb:3ZDM|rcsb pdb:4A20|rcsb pdb:4ASW|rcsb pdb:4GOC|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK - crc64:98AFFDB4EA51B40F crc64:CE6FC4282E0E472C comment:Interaction observed in GET3-/- cells. Additional chaperones, only identified as HSP70s, were also seen to have bound.|figure legend:Fig. 2A, Supp. Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/11/15 2017/11/15 rogid:t1xcIrahizw7d4/IGrx82rIEkOU559292 rogid:lKhHoZ+UA1ZcX8TOoZMgJX+fzI0559292 rigid:U7TbnpcLIg15IA2BnY3nVHyQlz4 false flag tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q12125 uniprotkb:Q12118 intact:EBI-36940|uniprotkb:D6W2M2|ensemblfungi:YOR164C intact:EBI-31784|uniprotkb:D6W273|ensemblfungi:YOR007C psi-mi:get4_yeast(display_long)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:O3580(orf name)|uniprotkb:YOR164C(locus name)|uniprotkb:Guided entry of tail-anchored proteins 4(gene name synonym) psi-mi:sgt2_yeast(display_long)|uniprotkb:Viral protein U-binding protein(gene name synonym)|uniprotkb:SGT/UBP(gene name synonym)|uniprotkb:SGT2(gene name)|psi-mi:SGT2(display_short)|uniprotkb:UNF346(orf name)|uniprotkb:YOR007C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16594741|imex:IM-26462-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000005690|refseq:NP_014807.3|mint:Q12125|dip:DIP-2005N|ensemblfungi:YOR164C(gene)|ensemblfungi:YOR164C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK refseq:NP_014649.1|sgd:S000005533|dip:DIP-1983N|mint:Q12118|ensemblfungi:YOR007C(gene)|ensemblfungi:YOR007C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072380"(TRC complex)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|rcsb pdb:2LXB|rcsb pdb:2LXC|rcsb pdb:3ZDM|rcsb pdb:4ASV|rcsb pdb:4ASW|rcsb pdb:5LYN|rcsb pdb:5LYP|reactome:R-SCE-9609523 - crc64:98AFFDB4EA51B40F crc64:33539B74F742BD3C comment:Interaction observed in GET3-/- cells. Additional chaperones, only identified as HSP70s, were also seen to have bound.|figure legend:Fig. 2A, Supp. Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/11/15 2017/11/15 rogid:t1xcIrahizw7d4/IGrx82rIEkOU559292 rogid:u4qztYWJIAVQOzZGnkLFnO3S2NA559292 rigid:U7TbnpcLIg15IA2BnY3nVHyQlz4 false flag tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q12125 uniprotkb:P31539 intact:EBI-36940|uniprotkb:D6W2M2|ensemblfungi:YOR164C intact:EBI-8050|uniprotkb:D6VXX8|ensemblfungi:YLL026W psi-mi:get4_yeast(display_long)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:O3580(orf name)|uniprotkb:YOR164C(locus name)|uniprotkb:Guided entry of tail-anchored proteins 4(gene name synonym) psi-mi:hs104_yeast(display_long)|uniprotkb:HSP104(gene name)|psi-mi:HSP104(display_short)|uniprotkb:YLL026W(locus name)|uniprotkb:L0948(orf name)|uniprotkb:Protein aggregation-remodeling factor HSP104(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16594741|imex:IM-26462-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000005690|refseq:NP_014807.3|mint:Q12125|dip:DIP-2005N|ensemblfungi:YOR164C(gene)|ensemblfungi:YOR164C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK sgd:S000003949|refseq:NP_013074.1|mint:P31539|dip:DIP-2252N|ensemblfungi:YLL026W(gene)|ensemblfungi:YLL026W_mRNA(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0042026"(protein refolding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043335"(protein unfolding)|go:"GO:0043531"(ADP binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070370"(cellular heat acclimation)|go:"GO:0070414"(trehalose metabolism in response to heat stress)|go:"GO:0072380"(TRC complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004176(Clp, N-terminal)|interpro:IPR018368|interpro:IPR019489|interpro:IPR027417|interpro:IPR028299|interpro:IPR036628|interpro:IPR041546|rcsb pdb:5KNE|rcsb pdb:5U2U|rcsb pdb:5VJH|rcsb pdb:5VY8|rcsb pdb:5VY9|rcsb pdb:5VYA|rcsb pdb:5WBW|rcsb pdb:6AHF|rcsb pdb:6AMN|rcsb pdb:6N8T|rcsb pdb:6N8V|rcsb pdb:6N8Z - crc64:98AFFDB4EA51B40F crc64:4AD0E7E3AF98E318 comment:Interaction observed in GET3-/- cells. Additional chaperones, only identified as HSP70s, were also seen to have bound.|figure legend:Fig. 2A, Supp. Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/11/15 2017/11/15 rogid:t1xcIrahizw7d4/IGrx82rIEkOU559292 rogid:rMl56qonOOODJUyLVkkWwUq8Cj4559292 rigid:U7TbnpcLIg15IA2BnY3nVHyQlz4 false flag tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q12125 uniprotkb:P38276 intact:EBI-36940|uniprotkb:D6W2M2|ensemblfungi:YOR164C intact:EBI-21630|uniprotkb:D6VQD3|ensemblfungi:YBR137W psi-mi:get4_yeast(display_long)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:O3580(orf name)|uniprotkb:YOR164C(locus name)|uniprotkb:Guided entry of tail-anchored proteins 4(gene name synonym) psi-mi:yby7_yeast(display_long)|uniprotkb:YBR1013(orf name)|uniprotkb:YBR137W(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16594741|imex:IM-26462-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000005690|refseq:NP_014807.3|mint:Q12125|dip:DIP-2005N|ensemblfungi:YOR164C(gene)|ensemblfungi:YOR164C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK refseq:NP_009695.2|sgd:S000000341|mint:P38276|dip:DIP-2038N|ensemblfungi:YBR137W(gene)|ensemblfungi:YBR137W_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR005624(Protein of unknown function DUF336)|interpro:IPR010371(Protein of unknown function DUF967)|interpro:IPR038084|rcsb pdb:4CLC - crc64:98AFFDB4EA51B40F crc64:8CBA454492E29273 comment:Interaction observed in GET3-/- cells. Additional chaperones, only identified as HSP70s, were also seen to have bound.|figure legend:Fig. 2A, Supp. Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/11/15 2017/11/15 rogid:t1xcIrahizw7d4/IGrx82rIEkOU559292 rogid:UsO9ZYVJXLI50JBd/g0C1NtSeXI559292 rigid:U7TbnpcLIg15IA2BnY3nVHyQlz4 false flag tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q12285 uniprotkb:Q12118 intact:EBI-34904|uniprotkb:D6W1V6|ensemblfungi:YOL111C intact:EBI-31784|uniprotkb:D6W273|ensemblfungi:YOR007C psi-mi:mdy2_yeast(display_long)|uniprotkb:MDY2(gene name)|psi-mi:MDY2(display_short)|uniprotkb:TMA24(gene name synonym)|uniprotkb:Mating-deficient protein 2(gene name synonym)|uniprotkb:Translation machinery-associated protein 24(gene name synonym)|uniprotkb:GET5(gene name synonym)|uniprotkb:Golgi to ER traffic protein 5(gene name synonym)|uniprotkb:YOL111C(locus name) psi-mi:sgt2_yeast(display_long)|uniprotkb:Viral protein U-binding protein(gene name synonym)|uniprotkb:SGT/UBP(gene name synonym)|uniprotkb:SGT2(gene name)|psi-mi:SGT2(display_short)|uniprotkb:UNF346(orf name)|uniprotkb:YOR007C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16594752|imex:IM-26462-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014530.1|sgd:S000005471|mint:Q12285|dip:DIP-1982N|ensemblfungi:YOL111C(gene)|ensemblfungi:YOL111C_mRNA(transcript)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR031765|interpro:IPR040474|rcsb pdb:2LNZ|rcsb pdb:2LXA|rcsb pdb:2LXC|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:3VEJ|rcsb pdb:3ZDM|rcsb pdb:4A20|rcsb pdb:4ASW|rcsb pdb:4GOC|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK refseq:NP_014649.1|sgd:S000005533|dip:DIP-1983N|mint:Q12118|ensemblfungi:YOR007C(gene)|ensemblfungi:YOR007C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072380"(TRC complex)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|rcsb pdb:2LXB|rcsb pdb:2LXC|rcsb pdb:3ZDM|rcsb pdb:4ASV|rcsb pdb:4ASW|rcsb pdb:5LYN|rcsb pdb:5LYP|reactome:R-SCE-9609523 - crc64:CE6FC4282E0E472C crc64:33539B74F742BD3C comment:Interaction observed in GET4-/- cells.|figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/11/15 2017/11/15 rogid:lKhHoZ+UA1ZcX8TOoZMgJX+fzI0559292 rogid:u4qztYWJIAVQOzZGnkLFnO3S2NA559292 rigid:ZAmsdAuF6gCrKEoidpaCfRIjqPE false flag tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q12285 uniprotkb:P38276 intact:EBI-34904|uniprotkb:D6W1V6|ensemblfungi:YOL111C intact:EBI-21630|uniprotkb:D6VQD3|ensemblfungi:YBR137W psi-mi:mdy2_yeast(display_long)|uniprotkb:MDY2(gene name)|psi-mi:MDY2(display_short)|uniprotkb:TMA24(gene name synonym)|uniprotkb:Mating-deficient protein 2(gene name synonym)|uniprotkb:Translation machinery-associated protein 24(gene name synonym)|uniprotkb:GET5(gene name synonym)|uniprotkb:Golgi to ER traffic protein 5(gene name synonym)|uniprotkb:YOL111C(locus name) psi-mi:yby7_yeast(display_long)|uniprotkb:YBR1013(orf name)|uniprotkb:YBR137W(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16594752|imex:IM-26462-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014530.1|sgd:S000005471|mint:Q12285|dip:DIP-1982N|ensemblfungi:YOL111C(gene)|ensemblfungi:YOL111C_mRNA(transcript)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR031765|interpro:IPR040474|rcsb pdb:2LNZ|rcsb pdb:2LXA|rcsb pdb:2LXC|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:3VEJ|rcsb pdb:3ZDM|rcsb pdb:4A20|rcsb pdb:4ASW|rcsb pdb:4GOC|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK refseq:NP_009695.2|sgd:S000000341|mint:P38276|dip:DIP-2038N|ensemblfungi:YBR137W(gene)|ensemblfungi:YBR137W_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR005624(Protein of unknown function DUF336)|interpro:IPR010371(Protein of unknown function DUF967)|interpro:IPR038084|rcsb pdb:4CLC - crc64:CE6FC4282E0E472C crc64:8CBA454492E29273 comment:Interaction observed in GET4-/- cells.|figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/11/15 2017/11/15 rogid:lKhHoZ+UA1ZcX8TOoZMgJX+fzI0559292 rogid:UsO9ZYVJXLI50JBd/g0C1NtSeXI559292 rigid:ZAmsdAuF6gCrKEoidpaCfRIjqPE false flag tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q12285 uniprotkb:Q12125 intact:EBI-34904|uniprotkb:D6W1V6|ensemblfungi:YOL111C intact:EBI-36940|uniprotkb:D6W2M2|ensemblfungi:YOR164C psi-mi:mdy2_yeast(display_long)|uniprotkb:MDY2(gene name)|psi-mi:MDY2(display_short)|uniprotkb:TMA24(gene name synonym)|uniprotkb:Mating-deficient protein 2(gene name synonym)|uniprotkb:Translation machinery-associated protein 24(gene name synonym)|uniprotkb:GET5(gene name synonym)|uniprotkb:Golgi to ER traffic protein 5(gene name synonym)|uniprotkb:YOL111C(locus name) psi-mi:get4_yeast(display_long)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:O3580(orf name)|uniprotkb:YOR164C(locus name)|uniprotkb:Guided entry of tail-anchored proteins 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16594760|imex:IM-26462-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014530.1|sgd:S000005471|mint:Q12285|dip:DIP-1982N|ensemblfungi:YOL111C(gene)|ensemblfungi:YOL111C_mRNA(transcript)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR031765|interpro:IPR040474|rcsb pdb:2LNZ|rcsb pdb:2LXA|rcsb pdb:2LXC|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:3VEJ|rcsb pdb:3ZDM|rcsb pdb:4A20|rcsb pdb:4ASW|rcsb pdb:4GOC|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK sgd:S000005690|refseq:NP_014807.3|mint:Q12125|dip:DIP-2005N|ensemblfungi:YOR164C(gene)|ensemblfungi:YOR164C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK - crc64:CE6FC4282E0E472C crc64:98AFFDB4EA51B40F comment:Interaction observed in SGT2-/- cells.|figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/11/15 2017/11/15 rogid:lKhHoZ+UA1ZcX8TOoZMgJX+fzI0559292 rogid:t1xcIrahizw7d4/IGrx82rIEkOU559292 rigid:fkMm0OkN22Ito7X24btlNd3+BOU false flag tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q12125 uniprotkb:Q12285 intact:EBI-36940|uniprotkb:D6W2M2|ensemblfungi:YOR164C intact:EBI-34904|uniprotkb:D6W1V6|ensemblfungi:YOL111C psi-mi:get4_yeast(display_long)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:O3580(orf name)|uniprotkb:YOR164C(locus name)|uniprotkb:Guided entry of tail-anchored proteins 4(gene name synonym) psi-mi:mdy2_yeast(display_long)|uniprotkb:MDY2(gene name)|psi-mi:MDY2(display_short)|uniprotkb:TMA24(gene name synonym)|uniprotkb:Mating-deficient protein 2(gene name synonym)|uniprotkb:Translation machinery-associated protein 24(gene name synonym)|uniprotkb:GET5(gene name synonym)|uniprotkb:Golgi to ER traffic protein 5(gene name synonym)|uniprotkb:YOL111C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16594767|imex:IM-26462-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000005690|refseq:NP_014807.3|mint:Q12125|dip:DIP-2005N|ensemblfungi:YOR164C(gene)|ensemblfungi:YOR164C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK refseq:NP_014530.1|sgd:S000005471|mint:Q12285|dip:DIP-1982N|ensemblfungi:YOL111C(gene)|ensemblfungi:YOL111C_mRNA(transcript)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR031765|interpro:IPR040474|rcsb pdb:2LNZ|rcsb pdb:2LXA|rcsb pdb:2LXC|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:3VEJ|rcsb pdb:3ZDM|rcsb pdb:4A20|rcsb pdb:4ASW|rcsb pdb:4GOC|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK - crc64:98AFFDB4EA51B40F crc64:CE6FC4282E0E472C comment:Interaction observed in YBR137W-/- cells. Additional chaperones, only identified as HSP70s, were also seen to have bound.|figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/11/15 2017/11/15 rogid:t1xcIrahizw7d4/IGrx82rIEkOU559292 rogid:lKhHoZ+UA1ZcX8TOoZMgJX+fzI0559292 rigid:ULwZ7MClDaMJRjaPgcQqljg0Rz8 false flag tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q12125 uniprotkb:P31539 intact:EBI-36940|uniprotkb:D6W2M2|ensemblfungi:YOR164C intact:EBI-8050|uniprotkb:D6VXX8|ensemblfungi:YLL026W psi-mi:get4_yeast(display_long)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:O3580(orf name)|uniprotkb:YOR164C(locus name)|uniprotkb:Guided entry of tail-anchored proteins 4(gene name synonym) psi-mi:hs104_yeast(display_long)|uniprotkb:HSP104(gene name)|psi-mi:HSP104(display_short)|uniprotkb:YLL026W(locus name)|uniprotkb:L0948(orf name)|uniprotkb:Protein aggregation-remodeling factor HSP104(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16594767|imex:IM-26462-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000005690|refseq:NP_014807.3|mint:Q12125|dip:DIP-2005N|ensemblfungi:YOR164C(gene)|ensemblfungi:YOR164C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK sgd:S000003949|refseq:NP_013074.1|mint:P31539|dip:DIP-2252N|ensemblfungi:YLL026W(gene)|ensemblfungi:YLL026W_mRNA(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0042026"(protein refolding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043335"(protein unfolding)|go:"GO:0043531"(ADP binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070370"(cellular heat acclimation)|go:"GO:0070414"(trehalose metabolism in response to heat stress)|go:"GO:0072380"(TRC complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004176(Clp, N-terminal)|interpro:IPR018368|interpro:IPR019489|interpro:IPR027417|interpro:IPR028299|interpro:IPR036628|interpro:IPR041546|rcsb pdb:5KNE|rcsb pdb:5U2U|rcsb pdb:5VJH|rcsb pdb:5VY8|rcsb pdb:5VY9|rcsb pdb:5VYA|rcsb pdb:5WBW|rcsb pdb:6AHF|rcsb pdb:6AMN|rcsb pdb:6N8T|rcsb pdb:6N8V|rcsb pdb:6N8Z - crc64:98AFFDB4EA51B40F crc64:4AD0E7E3AF98E318 comment:Interaction observed in YBR137W-/- cells. Additional chaperones, only identified as HSP70s, were also seen to have bound.|figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/11/15 2017/11/15 rogid:t1xcIrahizw7d4/IGrx82rIEkOU559292 rogid:rMl56qonOOODJUyLVkkWwUq8Cj4559292 rigid:ULwZ7MClDaMJRjaPgcQqljg0Rz8 false flag tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q12125 uniprotkb:Q12118 intact:EBI-36940|uniprotkb:D6W2M2|ensemblfungi:YOR164C intact:EBI-31784|uniprotkb:D6W273|ensemblfungi:YOR007C psi-mi:get4_yeast(display_long)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:O3580(orf name)|uniprotkb:YOR164C(locus name)|uniprotkb:Guided entry of tail-anchored proteins 4(gene name synonym) psi-mi:sgt2_yeast(display_long)|uniprotkb:Viral protein U-binding protein(gene name synonym)|uniprotkb:SGT/UBP(gene name synonym)|uniprotkb:SGT2(gene name)|psi-mi:SGT2(display_short)|uniprotkb:UNF346(orf name)|uniprotkb:YOR007C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16594767|imex:IM-26462-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000005690|refseq:NP_014807.3|mint:Q12125|dip:DIP-2005N|ensemblfungi:YOR164C(gene)|ensemblfungi:YOR164C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK refseq:NP_014649.1|sgd:S000005533|dip:DIP-1983N|mint:Q12118|ensemblfungi:YOR007C(gene)|ensemblfungi:YOR007C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072380"(TRC complex)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|rcsb pdb:2LXB|rcsb pdb:2LXC|rcsb pdb:3ZDM|rcsb pdb:4ASV|rcsb pdb:4ASW|rcsb pdb:5LYN|rcsb pdb:5LYP|reactome:R-SCE-9609523 - crc64:98AFFDB4EA51B40F crc64:33539B74F742BD3C comment:Interaction observed in YBR137W-/- cells. Additional chaperones, only identified as HSP70s, were also seen to have bound.|figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/11/15 2017/11/15 rogid:t1xcIrahizw7d4/IGrx82rIEkOU559292 rogid:u4qztYWJIAVQOzZGnkLFnO3S2NA559292 rigid:ULwZ7MClDaMJRjaPgcQqljg0Rz8 false flag tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q12118 uniprotkb:P25294 intact:EBI-31784|uniprotkb:D6W273|ensemblfungi:YOR007C intact:EBI-17244|uniprotkb:D6W1H0|ensemblfungi:YNL007C psi-mi:sgt2_yeast(display_long)|uniprotkb:Viral protein U-binding protein(gene name synonym)|uniprotkb:SGT/UBP(gene name synonym)|uniprotkb:SGT2(gene name)|psi-mi:SGT2(display_short)|uniprotkb:UNF346(orf name)|uniprotkb:YOR007C(locus name) psi-mi:sis1_yeast(display_long)|uniprotkb:YNL007C(locus name)|uniprotkb:SIS1(gene name)|psi-mi:SIS1(display_short)|uniprotkb:N2879(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16717876|imex:IM-26462-43 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014649.1|sgd:S000005533|dip:DIP-1983N|mint:Q12118|ensemblfungi:YOR007C(gene)|ensemblfungi:YOR007C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072380"(TRC complex)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|rcsb pdb:2LXB|rcsb pdb:2LXC|rcsb pdb:3ZDM|rcsb pdb:4ASV|rcsb pdb:4ASW|rcsb pdb:5LYN|rcsb pdb:5LYP|reactome:R-SCE-9609523 refseq:NP_014391.1|sgd:S000004952|ensemblfungi:YNL007C(gene)|ensemblfungi:YNL007C_mRNA(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006413"(translational initiation)|go:"GO:0006457"(protein folding)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0035719"(tRNA import into nucleus)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0070843"(misfolded protein transport)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|rcsb pdb:1C3G|rcsb pdb:2B26|rcsb pdb:4RWU|rcsb pdb:6D6X|go:"GO:0007049"(cell cycle)|dip:DIP-4385N|mint:P25294 - crc64:33539B74F742BD3C crc64:642D3709C0FD5682 comment:Interaction observed in GET3-/- cells. Additional chaperones, only identified as HSP70s, were also seen to have bound.|figure legend:Fig. 2E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/11/15 2018/01/04 rogid:u4qztYWJIAVQOzZGnkLFnO3S2NA559292 rogid:gp39i5OLzpajm1XnD9cYtGKD6kU559292 rigid:jsldKCUXgIshZ0+f0pj1jscSerI false flag tag:?-?|mutation disrupting interaction strength:171-171,175-175 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q12118 uniprotkb:P31539 intact:EBI-31784|uniprotkb:D6W273|ensemblfungi:YOR007C intact:EBI-8050|uniprotkb:D6VXX8|ensemblfungi:YLL026W psi-mi:sgt2_yeast(display_long)|uniprotkb:Viral protein U-binding protein(gene name synonym)|uniprotkb:SGT/UBP(gene name synonym)|uniprotkb:SGT2(gene name)|psi-mi:SGT2(display_short)|uniprotkb:UNF346(orf name)|uniprotkb:YOR007C(locus name) psi-mi:hs104_yeast(display_long)|uniprotkb:HSP104(gene name)|psi-mi:HSP104(display_short)|uniprotkb:YLL026W(locus name)|uniprotkb:L0948(orf name)|uniprotkb:Protein aggregation-remodeling factor HSP104(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16717876|imex:IM-26462-43 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014649.1|sgd:S000005533|dip:DIP-1983N|mint:Q12118|ensemblfungi:YOR007C(gene)|ensemblfungi:YOR007C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072380"(TRC complex)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|rcsb pdb:2LXB|rcsb pdb:2LXC|rcsb pdb:3ZDM|rcsb pdb:4ASV|rcsb pdb:4ASW|rcsb pdb:5LYN|rcsb pdb:5LYP|reactome:R-SCE-9609523 sgd:S000003949|refseq:NP_013074.1|mint:P31539|dip:DIP-2252N|ensemblfungi:YLL026W(gene)|ensemblfungi:YLL026W_mRNA(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0042026"(protein refolding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043335"(protein unfolding)|go:"GO:0043531"(ADP binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070370"(cellular heat acclimation)|go:"GO:0070414"(trehalose metabolism in response to heat stress)|go:"GO:0072380"(TRC complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004176(Clp, N-terminal)|interpro:IPR018368|interpro:IPR019489|interpro:IPR027417|interpro:IPR028299|interpro:IPR036628|interpro:IPR041546|rcsb pdb:5KNE|rcsb pdb:5U2U|rcsb pdb:5VJH|rcsb pdb:5VY8|rcsb pdb:5VY9|rcsb pdb:5VYA|rcsb pdb:5WBW|rcsb pdb:6AHF|rcsb pdb:6AMN|rcsb pdb:6N8T|rcsb pdb:6N8V|rcsb pdb:6N8Z - crc64:33539B74F742BD3C crc64:4AD0E7E3AF98E318 comment:Interaction observed in GET3-/- cells. Additional chaperones, only identified as HSP70s, were also seen to have bound.|figure legend:Fig. 2E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/11/15 2018/01/04 rogid:u4qztYWJIAVQOzZGnkLFnO3S2NA559292 rogid:rMl56qonOOODJUyLVkkWwUq8Cj4559292 rigid:jsldKCUXgIshZ0+f0pj1jscSerI false flag tag:?-?|mutation disrupting interaction strength:171-171,175-175 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q12118 uniprotkb:P38276 intact:EBI-31784|uniprotkb:D6W273|ensemblfungi:YOR007C intact:EBI-21630|uniprotkb:D6VQD3|ensemblfungi:YBR137W psi-mi:sgt2_yeast(display_long)|uniprotkb:Viral protein U-binding protein(gene name synonym)|uniprotkb:SGT/UBP(gene name synonym)|uniprotkb:SGT2(gene name)|psi-mi:SGT2(display_short)|uniprotkb:UNF346(orf name)|uniprotkb:YOR007C(locus name) psi-mi:yby7_yeast(display_long)|uniprotkb:YBR1013(orf name)|uniprotkb:YBR137W(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16717876|imex:IM-26462-43 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014649.1|sgd:S000005533|dip:DIP-1983N|mint:Q12118|ensemblfungi:YOR007C(gene)|ensemblfungi:YOR007C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072380"(TRC complex)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|rcsb pdb:2LXB|rcsb pdb:2LXC|rcsb pdb:3ZDM|rcsb pdb:4ASV|rcsb pdb:4ASW|rcsb pdb:5LYN|rcsb pdb:5LYP|reactome:R-SCE-9609523 refseq:NP_009695.2|sgd:S000000341|mint:P38276|dip:DIP-2038N|ensemblfungi:YBR137W(gene)|ensemblfungi:YBR137W_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR005624(Protein of unknown function DUF336)|interpro:IPR010371(Protein of unknown function DUF967)|interpro:IPR038084|rcsb pdb:4CLC - crc64:33539B74F742BD3C crc64:8CBA454492E29273 comment:Interaction observed in GET3-/- cells. Additional chaperones, only identified as HSP70s, were also seen to have bound.|figure legend:Fig. 2E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/11/15 2018/01/04 rogid:u4qztYWJIAVQOzZGnkLFnO3S2NA559292 rogid:UsO9ZYVJXLI50JBd/g0C1NtSeXI559292 rigid:jsldKCUXgIshZ0+f0pj1jscSerI false flag tag:?-?|mutation disrupting interaction strength:171-171,175-175 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q12154 uniprotkb:P22214 intact:EBI-2989|uniprotkb:Q6B1B6|uniprotkb:D6VRQ0|ensemblfungi:YDL100C intact:EBI-16577|ensemblfungi:YLR268W|uniprotkb:D6VYR6 psi-mi:get3_yeast(display_long)|uniprotkb:YDL100C(locus name)|uniprotkb:GET3(gene name)|psi-mi:GET3(display_short)|uniprotkb:ARR4(gene name synonym)|uniprotkb:D2371(orf name)|uniprotkb:Arsenical pump-driving ATPase(gene name synonym)|uniprotkb:Arsenite-stimulated ATPase(gene name synonym)|uniprotkb:Guided entry of tail-anchored proteins 3(gene name synonym)|uniprotkb:Golgi to ER traffic protein 3(gene name synonym) psi-mi:sec22_yeast(display_long)|uniprotkb:SEC22(gene name)|psi-mi:SEC22(display_short)|uniprotkb:SLY2(gene name synonym)|uniprotkb:YLR268W(locus name)|uniprotkb:L8479.3(orf name)|uniprotkb:TSL26(gene name synonym)|uniprotkb:Suppressor of loss of YPT1 protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16717589|imex:IM-26462-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010183.1|sgd:S000002258|dip:DIP-3908N|mint:Q12154|ensemblfungi:YDL100C(gene)|ensemblfungi:YDL100C_mRNA(transcript)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0009408"(response to heat)|go:"GO:0010038"(response to metal ion)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043529"(GET complex)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1990507"(obsolete ATP-independent chaperone mediated protein folding)|interpro:IPR016300(Arsenite-transporting ATPase)|interpro:IPR025723|interpro:IPR027417|interpro:IPR027542|rcsb pdb:2WOJ|rcsb pdb:3A36|rcsb pdb:3A37|rcsb pdb:3B2E|rcsb pdb:3H84|rcsb pdb:3IDQ|rcsb pdb:3SJA|rcsb pdb:3SJB|rcsb pdb:3SJC|rcsb pdb:3SJD|rcsb pdb:3VLC|rcsb pdb:3ZS8|rcsb pdb:3ZS9|rcsb pdb:4PWX|rcsb pdb:4XTR|rcsb pdb:4XVU|rcsb pdb:4XWO|rcsb pdb:5BW8|rcsb pdb:5BWK refseq:NP_013370.1|sgd:S000004258|ensemblfungi:YLR268W(gene)|ensemblfungi:YLR268W_mRNA(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0048279"(vesicle fusion with endoplasmic reticulum)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|go:"GO:0000139"(Golgi membrane)|reactome:R-SCE-204005|reactome:R-SCE-5694530|reactome:R-SCE-6811434|dip:DIP-2234N - crc64:F795C359B5A4A461 crc64:9FA3E34EAAFB9536 figure legend:Fig. 1A, 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/01/04 rogid:Y+PTDg+beVeCH5mn4BvWi5wBP4A559292 rogid:TjDU0GL+v84S+TwvRpJmF9CqhZ4559292 rigid:JONx/7dp6QPdkeI7UEO1xsQRRfs false flag tag:?-? 35s radiolabel:?-?|necessary binding region:188-214 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q12154 uniprotkb:Q12285 intact:EBI-2989|uniprotkb:Q6B1B6|uniprotkb:D6VRQ0|ensemblfungi:YDL100C intact:EBI-34904|uniprotkb:D6W1V6|ensemblfungi:YOL111C psi-mi:get3_yeast(display_long)|uniprotkb:YDL100C(locus name)|uniprotkb:GET3(gene name)|psi-mi:GET3(display_short)|uniprotkb:ARR4(gene name synonym)|uniprotkb:D2371(orf name)|uniprotkb:Arsenical pump-driving ATPase(gene name synonym)|uniprotkb:Arsenite-stimulated ATPase(gene name synonym)|uniprotkb:Guided entry of tail-anchored proteins 3(gene name synonym)|uniprotkb:Golgi to ER traffic protein 3(gene name synonym) psi-mi:mdy2_yeast(display_long)|uniprotkb:MDY2(gene name)|psi-mi:MDY2(display_short)|uniprotkb:TMA24(gene name synonym)|uniprotkb:Mating-deficient protein 2(gene name synonym)|uniprotkb:Translation machinery-associated protein 24(gene name synonym)|uniprotkb:GET5(gene name synonym)|uniprotkb:Golgi to ER traffic protein 5(gene name synonym)|uniprotkb:YOL111C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16717589|imex:IM-26462-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010183.1|sgd:S000002258|dip:DIP-3908N|mint:Q12154|ensemblfungi:YDL100C(gene)|ensemblfungi:YDL100C_mRNA(transcript)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0009408"(response to heat)|go:"GO:0010038"(response to metal ion)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043529"(GET complex)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1990507"(obsolete ATP-independent chaperone mediated protein folding)|interpro:IPR016300(Arsenite-transporting ATPase)|interpro:IPR025723|interpro:IPR027417|interpro:IPR027542|rcsb pdb:2WOJ|rcsb pdb:3A36|rcsb pdb:3A37|rcsb pdb:3B2E|rcsb pdb:3H84|rcsb pdb:3IDQ|rcsb pdb:3SJA|rcsb pdb:3SJB|rcsb pdb:3SJC|rcsb pdb:3SJD|rcsb pdb:3VLC|rcsb pdb:3ZS8|rcsb pdb:3ZS9|rcsb pdb:4PWX|rcsb pdb:4XTR|rcsb pdb:4XVU|rcsb pdb:4XWO|rcsb pdb:5BW8|rcsb pdb:5BWK refseq:NP_014530.1|sgd:S000005471|mint:Q12285|dip:DIP-1982N|ensemblfungi:YOL111C(gene)|ensemblfungi:YOL111C_mRNA(transcript)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR031765|interpro:IPR040474|rcsb pdb:2LNZ|rcsb pdb:2LXA|rcsb pdb:2LXC|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:3VEJ|rcsb pdb:3ZDM|rcsb pdb:4A20|rcsb pdb:4ASW|rcsb pdb:4GOC|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK - crc64:F795C359B5A4A461 crc64:CE6FC4282E0E472C figure legend:Fig. 1A, 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/01/04 rogid:Y+PTDg+beVeCH5mn4BvWi5wBP4A559292 rogid:lKhHoZ+UA1ZcX8TOoZMgJX+fzI0559292 rigid:JONx/7dp6QPdkeI7UEO1xsQRRfs false flag tag:?-? - - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0113"(western blot) uniprotkb:Q12154 uniprotkb:Q12125 intact:EBI-2989|uniprotkb:Q6B1B6|uniprotkb:D6VRQ0|ensemblfungi:YDL100C intact:EBI-36940|uniprotkb:D6W2M2|ensemblfungi:YOR164C psi-mi:get3_yeast(display_long)|uniprotkb:YDL100C(locus name)|uniprotkb:GET3(gene name)|psi-mi:GET3(display_short)|uniprotkb:ARR4(gene name synonym)|uniprotkb:D2371(orf name)|uniprotkb:Arsenical pump-driving ATPase(gene name synonym)|uniprotkb:Arsenite-stimulated ATPase(gene name synonym)|uniprotkb:Guided entry of tail-anchored proteins 3(gene name synonym)|uniprotkb:Golgi to ER traffic protein 3(gene name synonym) psi-mi:get4_yeast(display_long)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:O3580(orf name)|uniprotkb:YOR164C(locus name)|uniprotkb:Guided entry of tail-anchored proteins 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16717589|imex:IM-26462-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010183.1|sgd:S000002258|dip:DIP-3908N|mint:Q12154|ensemblfungi:YDL100C(gene)|ensemblfungi:YDL100C_mRNA(transcript)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0009408"(response to heat)|go:"GO:0010038"(response to metal ion)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043529"(GET complex)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1990507"(obsolete ATP-independent chaperone mediated protein folding)|interpro:IPR016300(Arsenite-transporting ATPase)|interpro:IPR025723|interpro:IPR027417|interpro:IPR027542|rcsb pdb:2WOJ|rcsb pdb:3A36|rcsb pdb:3A37|rcsb pdb:3B2E|rcsb pdb:3H84|rcsb pdb:3IDQ|rcsb pdb:3SJA|rcsb pdb:3SJB|rcsb pdb:3SJC|rcsb pdb:3SJD|rcsb pdb:3VLC|rcsb pdb:3ZS8|rcsb pdb:3ZS9|rcsb pdb:4PWX|rcsb pdb:4XTR|rcsb pdb:4XVU|rcsb pdb:4XWO|rcsb pdb:5BW8|rcsb pdb:5BWK sgd:S000005690|refseq:NP_014807.3|mint:Q12125|dip:DIP-2005N|ensemblfungi:YOR164C(gene)|ensemblfungi:YOR164C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK - crc64:F795C359B5A4A461 crc64:98AFFDB4EA51B40F figure legend:Fig. 1A, 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/01/04 rogid:Y+PTDg+beVeCH5mn4BvWi5wBP4A559292 rogid:t1xcIrahizw7d4/IGrx82rIEkOU559292 rigid:JONx/7dp6QPdkeI7UEO1xsQRRfs false flag tag:?-? - - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0113"(western blot) uniprotkb:P22214 uniprotkb:Q12125 intact:EBI-16577|ensemblfungi:YLR268W|uniprotkb:D6VYR6 intact:EBI-36940|uniprotkb:D6W2M2|ensemblfungi:YOR164C psi-mi:sec22_yeast(display_long)|uniprotkb:SEC22(gene name)|psi-mi:SEC22(display_short)|uniprotkb:SLY2(gene name synonym)|uniprotkb:YLR268W(locus name)|uniprotkb:L8479.3(orf name)|uniprotkb:TSL26(gene name synonym)|uniprotkb:Suppressor of loss of YPT1 protein 2(gene name synonym) psi-mi:get4_yeast(display_long)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:O3580(orf name)|uniprotkb:YOR164C(locus name)|uniprotkb:Guided entry of tail-anchored proteins 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16717632|imex:IM-26462-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_013370.1|sgd:S000004258|ensemblfungi:YLR268W(gene)|ensemblfungi:YLR268W_mRNA(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0048279"(vesicle fusion with endoplasmic reticulum)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|go:"GO:0000139"(Golgi membrane)|reactome:R-SCE-204005|reactome:R-SCE-5694530|reactome:R-SCE-6811434|dip:DIP-2234N sgd:S000005690|refseq:NP_014807.3|mint:Q12125|dip:DIP-2005N|ensemblfungi:YOR164C(gene)|ensemblfungi:YOR164C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK - crc64:9FA3E34EAAFB9536 crc64:98AFFDB4EA51B40F figure legend:Figs. 1C, 1D, Supp. Figs. 1B, 1D|comment:Interaction observed in get3-/- cells however incubation of recombinant GET3 with GET4FLAG-SEC22 bound to anti-FLAG resin resulted in SEC22 elution|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/01/04 rogid:TjDU0GL+v84S+TwvRpJmF9CqhZ4559292 rogid:t1xcIrahizw7d4/IGrx82rIEkOU559292 rigid:1CB1yeDKfb4+niCijPbG26dOYX0 false 35s radiolabel:?-?|necessary binding region:188-214 flag tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q12285 uniprotkb:P22214 intact:EBI-34904|uniprotkb:D6W1V6|ensemblfungi:YOL111C intact:EBI-16577|ensemblfungi:YLR268W|uniprotkb:D6VYR6 psi-mi:mdy2_yeast(display_long)|uniprotkb:MDY2(gene name)|psi-mi:MDY2(display_short)|uniprotkb:TMA24(gene name synonym)|uniprotkb:Mating-deficient protein 2(gene name synonym)|uniprotkb:Translation machinery-associated protein 24(gene name synonym)|uniprotkb:GET5(gene name synonym)|uniprotkb:Golgi to ER traffic protein 5(gene name synonym)|uniprotkb:YOL111C(locus name) psi-mi:sec22_yeast(display_long)|uniprotkb:SEC22(gene name)|psi-mi:SEC22(display_short)|uniprotkb:SLY2(gene name synonym)|uniprotkb:YLR268W(locus name)|uniprotkb:L8479.3(orf name)|uniprotkb:TSL26(gene name synonym)|uniprotkb:Suppressor of loss of YPT1 protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16717652|imex:IM-26462-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014530.1|sgd:S000005471|mint:Q12285|dip:DIP-1982N|ensemblfungi:YOL111C(gene)|ensemblfungi:YOL111C_mRNA(transcript)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR031765|interpro:IPR040474|rcsb pdb:2LNZ|rcsb pdb:2LXA|rcsb pdb:2LXC|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:3VEJ|rcsb pdb:3ZDM|rcsb pdb:4A20|rcsb pdb:4ASW|rcsb pdb:4GOC|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK refseq:NP_013370.1|sgd:S000004258|ensemblfungi:YLR268W(gene)|ensemblfungi:YLR268W_mRNA(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0048279"(vesicle fusion with endoplasmic reticulum)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|go:"GO:0000139"(Golgi membrane)|reactome:R-SCE-204005|reactome:R-SCE-5694530|reactome:R-SCE-6811434|dip:DIP-2234N - crc64:CE6FC4282E0E472C crc64:9FA3E34EAAFB9536 figure legend:Fig. 1C, 2C|comment:Interaction observed in get3-/- cells|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/01/04 rogid:lKhHoZ+UA1ZcX8TOoZMgJX+fzI0559292 rogid:TjDU0GL+v84S+TwvRpJmF9CqhZ4559292 rigid:7xDFlH7OW4hjWoTdPjyAHhsG4x8 false flag tag:?-? 35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q12285 uniprotkb:Q12118 intact:EBI-34904|uniprotkb:D6W1V6|ensemblfungi:YOL111C intact:EBI-31784|uniprotkb:D6W273|ensemblfungi:YOR007C psi-mi:mdy2_yeast(display_long)|uniprotkb:MDY2(gene name)|psi-mi:MDY2(display_short)|uniprotkb:TMA24(gene name synonym)|uniprotkb:Mating-deficient protein 2(gene name synonym)|uniprotkb:Translation machinery-associated protein 24(gene name synonym)|uniprotkb:GET5(gene name synonym)|uniprotkb:Golgi to ER traffic protein 5(gene name synonym)|uniprotkb:YOL111C(locus name) psi-mi:sgt2_yeast(display_long)|uniprotkb:Viral protein U-binding protein(gene name synonym)|uniprotkb:SGT/UBP(gene name synonym)|uniprotkb:SGT2(gene name)|psi-mi:SGT2(display_short)|uniprotkb:UNF346(orf name)|uniprotkb:YOR007C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16717652|imex:IM-26462-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014530.1|sgd:S000005471|mint:Q12285|dip:DIP-1982N|ensemblfungi:YOL111C(gene)|ensemblfungi:YOL111C_mRNA(transcript)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR031765|interpro:IPR040474|rcsb pdb:2LNZ|rcsb pdb:2LXA|rcsb pdb:2LXC|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:3VEJ|rcsb pdb:3ZDM|rcsb pdb:4A20|rcsb pdb:4ASW|rcsb pdb:4GOC|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK refseq:NP_014649.1|sgd:S000005533|dip:DIP-1983N|mint:Q12118|ensemblfungi:YOR007C(gene)|ensemblfungi:YOR007C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072380"(TRC complex)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|rcsb pdb:2LXB|rcsb pdb:2LXC|rcsb pdb:3ZDM|rcsb pdb:4ASV|rcsb pdb:4ASW|rcsb pdb:5LYN|rcsb pdb:5LYP|reactome:R-SCE-9609523 - crc64:CE6FC4282E0E472C crc64:33539B74F742BD3C figure legend:Fig. 1C, 2C|comment:Interaction observed in get3-/- cells|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/01/04 rogid:lKhHoZ+UA1ZcX8TOoZMgJX+fzI0559292 rogid:u4qztYWJIAVQOzZGnkLFnO3S2NA559292 rigid:7xDFlH7OW4hjWoTdPjyAHhsG4x8 false flag tag:?-? - - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P22214 uniprotkb:Q12118 intact:EBI-16577|ensemblfungi:YLR268W|uniprotkb:D6VYR6 intact:EBI-31784|uniprotkb:D6W273|ensemblfungi:YOR007C psi-mi:sec22_yeast(display_long)|uniprotkb:SEC22(gene name)|psi-mi:SEC22(display_short)|uniprotkb:SLY2(gene name synonym)|uniprotkb:YLR268W(locus name)|uniprotkb:L8479.3(orf name)|uniprotkb:TSL26(gene name synonym)|uniprotkb:Suppressor of loss of YPT1 protein 2(gene name synonym) psi-mi:sgt2_yeast(display_long)|uniprotkb:Viral protein U-binding protein(gene name synonym)|uniprotkb:SGT/UBP(gene name synonym)|uniprotkb:SGT2(gene name)|psi-mi:SGT2(display_short)|uniprotkb:UNF346(orf name)|uniprotkb:YOR007C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16717862|imex:IM-26462-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_013370.1|sgd:S000004258|ensemblfungi:YLR268W(gene)|ensemblfungi:YLR268W_mRNA(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0048279"(vesicle fusion with endoplasmic reticulum)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|go:"GO:0000139"(Golgi membrane)|reactome:R-SCE-204005|reactome:R-SCE-5694530|reactome:R-SCE-6811434|dip:DIP-2234N refseq:NP_014649.1|sgd:S000005533|dip:DIP-1983N|mint:Q12118|ensemblfungi:YOR007C(gene)|ensemblfungi:YOR007C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072380"(TRC complex)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|rcsb pdb:2LXB|rcsb pdb:2LXC|rcsb pdb:3ZDM|rcsb pdb:4ASV|rcsb pdb:4ASW|rcsb pdb:5LYN|rcsb pdb:5LYP|reactome:R-SCE-9609523 - crc64:9FA3E34EAAFB9536 crc64:33539B74F742BD3C figure legend:Fig. 2D, 6A, 6C, 6D|comment:Interaction observed in get3-/-, get5-/-, and get3/5 -/- cells. When GET3, GET4, and GET5 proteins were used to elute SEC22 from the column, elution was observed in the combined presence of GET3, GET4, and GET5. All other incubations containing GET3 resulted in only marginal SEC22 elution. The remaining elutions, which contained GET4 and/or GET5 without GET3, were indistinguishable from background. Increasing concentrations of GET3 stimulated SEC22 elution, increasing concentrations of GET5 progressively reduced the efficiency of SEC22 elution and even at saturating concentrations of GET3, the rate of SEC22 elution was further increased by the addition of GET4-GET5.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/01/04 rogid:TjDU0GL+v84S+TwvRpJmF9CqhZ4559292 rogid:u4qztYWJIAVQOzZGnkLFnO3S2NA559292 rigid:vV2WkaDGuI7uyan6XTDM+sqcOrg false 35s radiolabel:?-?|necessary binding region:188-214 mutation with no effect:175-175,171-171|flag tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P22214 uniprotkb:Q12118 intact:EBI-16577|ensemblfungi:YLR268W|uniprotkb:D6VYR6 intact:EBI-31784|uniprotkb:D6W273|ensemblfungi:YOR007C psi-mi:sec22_yeast(display_long)|uniprotkb:SEC22(gene name)|psi-mi:SEC22(display_short)|uniprotkb:SLY2(gene name synonym)|uniprotkb:YLR268W(locus name)|uniprotkb:L8479.3(orf name)|uniprotkb:TSL26(gene name synonym)|uniprotkb:Suppressor of loss of YPT1 protein 2(gene name synonym) psi-mi:sgt2_yeast(display_long)|uniprotkb:Viral protein U-binding protein(gene name synonym)|uniprotkb:SGT/UBP(gene name synonym)|uniprotkb:SGT2(gene name)|psi-mi:SGT2(display_short)|uniprotkb:UNF346(orf name)|uniprotkb:YOR007C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16717889|imex:IM-26462-45 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_013370.1|sgd:S000004258|ensemblfungi:YLR268W(gene)|ensemblfungi:YLR268W_mRNA(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0048279"(vesicle fusion with endoplasmic reticulum)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|go:"GO:0000139"(Golgi membrane)|reactome:R-SCE-204005|reactome:R-SCE-5694530|reactome:R-SCE-6811434|dip:DIP-2234N refseq:NP_014649.1|sgd:S000005533|dip:DIP-1983N|mint:Q12118|ensemblfungi:YOR007C(gene)|ensemblfungi:YOR007C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072380"(TRC complex)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|rcsb pdb:2LXB|rcsb pdb:2LXC|rcsb pdb:3ZDM|rcsb pdb:4ASV|rcsb pdb:4ASW|rcsb pdb:5LYN|rcsb pdb:5LYP|reactome:R-SCE-9609523 - crc64:9FA3E34EAAFB9536 crc64:33539B74F742BD3C figure legend:Fig. 3B|comment:Interaction observed in get3-/- cells|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/01/04 rogid:TjDU0GL+v84S+TwvRpJmF9CqhZ4559292 rogid:u4qztYWJIAVQOzZGnkLFnO3S2NA559292 rigid:vV2WkaDGuI7uyan6XTDM+sqcOrg false 35s radiolabel:?-? necessary binding region:208-346|flag tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P40515 uniprotkb:Q12118 intact:EBI-25059|uniprotkb:D6VVL9|ensemblfungi:YIL065C intact:EBI-31784|uniprotkb:D6W273|ensemblfungi:YOR007C psi-mi:fis1_yeast(display_long)|uniprotkb:Mitochondrial division protein 2(gene name synonym)|uniprotkb:FIS1(gene name)|psi-mi:FIS1(display_short)|uniprotkb:MDV2(gene name synonym)|uniprotkb:YIL065C(locus name) psi-mi:sgt2_yeast(display_long)|uniprotkb:Viral protein U-binding protein(gene name synonym)|uniprotkb:SGT/UBP(gene name synonym)|uniprotkb:SGT2(gene name)|psi-mi:SGT2(display_short)|uniprotkb:UNF346(orf name)|uniprotkb:YOR007C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16717936|imex:IM-26462-27 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000001327|refseq:NP_012199.3|dip:DIP-1897N|reactome:R-SCE-9603798|ensemblfungi:YIL065C(gene)|ensemblfungi:YIL065C_mRNA(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005779"(integral component of peroxisomal membrane)|go:"GO:0007031"(peroxisome organization)|go:"GO:0016559"(peroxisome fission)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0090141"(positive regulation of mitochondrial fission)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016543(Tetratricopeptide repeat 11 Fission 1 protein)|interpro:IPR028058|interpro:IPR028061|interpro:IPR033745|rcsb pdb:1Y8M|rcsb pdb:2PQN|rcsb pdb:2PQR|rcsb pdb:3O48|rcsb pdb:3UUX refseq:NP_014649.1|sgd:S000005533|dip:DIP-1983N|mint:Q12118|ensemblfungi:YOR007C(gene)|ensemblfungi:YOR007C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072380"(TRC complex)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|rcsb pdb:2LXB|rcsb pdb:2LXC|rcsb pdb:3ZDM|rcsb pdb:4ASV|rcsb pdb:4ASW|rcsb pdb:5LYN|rcsb pdb:5LYP|reactome:R-SCE-9609523 - crc64:BD62D19524770536 crc64:33539B74F742BD3C figure legend:Fig. 4B|comment:Interaction observed in get5-/- cells|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/01/05 rogid:KRkQNanb9iSJ1rp+wV+XN4FqZDE559292 rogid:u4qztYWJIAVQOzZGnkLFnO3S2NA559292 rigid:W3eLtKXGPIgoomY+3GQc7LcenDI false 35s radiolabel:?-?|mutation increasing interaction strength:141-142,136-137|tag:c-c flag tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q12118 uniprotkb:P22214 intact:EBI-31784|uniprotkb:D6W273|ensemblfungi:YOR007C intact:EBI-16577|ensemblfungi:YLR268W|uniprotkb:D6VYR6 psi-mi:sgt2_yeast(display_long)|uniprotkb:Viral protein U-binding protein(gene name synonym)|uniprotkb:SGT/UBP(gene name synonym)|uniprotkb:SGT2(gene name)|psi-mi:SGT2(display_short)|uniprotkb:UNF346(orf name)|uniprotkb:YOR007C(locus name) psi-mi:sec22_yeast(display_long)|uniprotkb:SEC22(gene name)|psi-mi:SEC22(display_short)|uniprotkb:SLY2(gene name synonym)|uniprotkb:YLR268W(locus name)|uniprotkb:L8479.3(orf name)|uniprotkb:TSL26(gene name synonym)|uniprotkb:Suppressor of loss of YPT1 protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16717971|imex:IM-26462-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014649.1|sgd:S000005533|dip:DIP-1983N|mint:Q12118|ensemblfungi:YOR007C(gene)|ensemblfungi:YOR007C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072380"(TRC complex)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|rcsb pdb:2LXB|rcsb pdb:2LXC|rcsb pdb:3ZDM|rcsb pdb:4ASV|rcsb pdb:4ASW|rcsb pdb:5LYN|rcsb pdb:5LYP|reactome:R-SCE-9609523 refseq:NP_013370.1|sgd:S000004258|ensemblfungi:YLR268W(gene)|ensemblfungi:YLR268W_mRNA(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0048279"(vesicle fusion with endoplasmic reticulum)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|go:"GO:0000139"(Golgi membrane)|reactome:R-SCE-204005|reactome:R-SCE-5694530|reactome:R-SCE-6811434|dip:DIP-2234N - crc64:33539B74F742BD3C crc64:9FA3E34EAAFB9536 figure legend:Fig. 4C|comment:"Interaction observed in get5-/- and get3/5-/- cells. When GET3, GET4, and GEt5 proteins were used to elute SEC22 from the column, elution was observed in the combined presence of GET3, GET4, and GET5. (gly136leu,gly137leu,gly141leu,ala142leu)FIS1 was eluted with an efficiency comparable to that observed for SEC22, while FIS1 was not appreciably eluted under the same conditions"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/01/05 rogid:u4qztYWJIAVQOzZGnkLFnO3S2NA559292 rogid:TjDU0GL+v84S+TwvRpJmF9CqhZ4559292 rigid:3XAyV7NmoCxRzOdm8IZ9NJKX+2M false mutation with no effect:171-171,175-175|flag tag:?-? 35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q12118 uniprotkb:P40515 intact:EBI-31784|uniprotkb:D6W273|ensemblfungi:YOR007C intact:EBI-25059|uniprotkb:D6VVL9|ensemblfungi:YIL065C psi-mi:sgt2_yeast(display_long)|uniprotkb:Viral protein U-binding protein(gene name synonym)|uniprotkb:SGT/UBP(gene name synonym)|uniprotkb:SGT2(gene name)|psi-mi:SGT2(display_short)|uniprotkb:UNF346(orf name)|uniprotkb:YOR007C(locus name) psi-mi:fis1_yeast(display_long)|uniprotkb:Mitochondrial division protein 2(gene name synonym)|uniprotkb:FIS1(gene name)|psi-mi:FIS1(display_short)|uniprotkb:MDV2(gene name synonym)|uniprotkb:YIL065C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16717971|imex:IM-26462-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014649.1|sgd:S000005533|dip:DIP-1983N|mint:Q12118|ensemblfungi:YOR007C(gene)|ensemblfungi:YOR007C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072380"(TRC complex)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|rcsb pdb:2LXB|rcsb pdb:2LXC|rcsb pdb:3ZDM|rcsb pdb:4ASV|rcsb pdb:4ASW|rcsb pdb:5LYN|rcsb pdb:5LYP|reactome:R-SCE-9609523 sgd:S000001327|refseq:NP_012199.3|dip:DIP-1897N|reactome:R-SCE-9603798|ensemblfungi:YIL065C(gene)|ensemblfungi:YIL065C_mRNA(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005779"(integral component of peroxisomal membrane)|go:"GO:0007031"(peroxisome organization)|go:"GO:0016559"(peroxisome fission)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0090141"(positive regulation of mitochondrial fission)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016543(Tetratricopeptide repeat 11 Fission 1 protein)|interpro:IPR028058|interpro:IPR028061|interpro:IPR033745|rcsb pdb:1Y8M|rcsb pdb:2PQN|rcsb pdb:2PQR|rcsb pdb:3O48|rcsb pdb:3UUX - crc64:33539B74F742BD3C crc64:BD62D19524770536 figure legend:Fig. 4C|comment:"Interaction observed in get5-/- and get3/5-/- cells. When GET3, GET4, and GEt5 proteins were used to elute SEC22 from the column, elution was observed in the combined presence of GET3, GET4, and GET5. (gly136leu,gly137leu,gly141leu,ala142leu)FIS1 was eluted with an efficiency comparable to that observed for SEC22, while FIS1 was not appreciably eluted under the same conditions"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/01/05 rogid:u4qztYWJIAVQOzZGnkLFnO3S2NA559292 rogid:KRkQNanb9iSJ1rp+wV+XN4FqZDE559292 rigid:3XAyV7NmoCxRzOdm8IZ9NJKX+2M false mutation with no effect:171-171,175-175|flag tag:?-? 35s radiolabel:?-?|mutation:141-142,136-137 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P22214 uniprotkb:Q12118 intact:EBI-16577|ensemblfungi:YLR268W|uniprotkb:D6VYR6 intact:EBI-31784|uniprotkb:D6W273|ensemblfungi:YOR007C psi-mi:sec22_yeast(display_long)|uniprotkb:SEC22(gene name)|psi-mi:SEC22(display_short)|uniprotkb:SLY2(gene name synonym)|uniprotkb:YLR268W(locus name)|uniprotkb:L8479.3(orf name)|uniprotkb:TSL26(gene name synonym)|uniprotkb:Suppressor of loss of YPT1 protein 2(gene name synonym) psi-mi:sgt2_yeast(display_long)|uniprotkb:Viral protein U-binding protein(gene name synonym)|uniprotkb:SGT/UBP(gene name synonym)|uniprotkb:SGT2(gene name)|psi-mi:SGT2(display_short)|uniprotkb:UNF346(orf name)|uniprotkb:YOR007C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16717995|imex:IM-26462-29 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_013370.1|sgd:S000004258|ensemblfungi:YLR268W(gene)|ensemblfungi:YLR268W_mRNA(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0048279"(vesicle fusion with endoplasmic reticulum)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|go:"GO:0000139"(Golgi membrane)|reactome:R-SCE-204005|reactome:R-SCE-5694530|reactome:R-SCE-6811434|dip:DIP-2234N refseq:NP_014649.1|sgd:S000005533|dip:DIP-1983N|mint:Q12118|ensemblfungi:YOR007C(gene)|ensemblfungi:YOR007C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072380"(TRC complex)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|rcsb pdb:2LXB|rcsb pdb:2LXC|rcsb pdb:3ZDM|rcsb pdb:4ASV|rcsb pdb:4ASW|rcsb pdb:5LYN|rcsb pdb:5LYP|reactome:R-SCE-9609523 - crc64:9FA3E34EAAFB9536 crc64:33539B74F742BD3C figure legend:Fig. 5A, 5B, 5C, 6A Supp. Fig. 4E|comment:"Interaction observed in get3/5 -/- cells. When GET3, GET4, and GET5 proteins were used to elute SEC22 from the column, elution was observed in the combined presence of GET3, GET4, and GET5. All other incubations containing GET3 resulted in only marginal SEC22 elution. The remaining elutions, which contained GET4 and/or GET5 without GET3, were indistinguishable from background. SEC22 elution was abolished by three point mutations (GET3 L187E, F190E, and I212E) in GET3’s predicted TMD-binding site. Increasing concentrations of GET3 stimulated SEC22 elution. There was no no apparent decrease in SEC22 elution from SGT2R171A, R175A under any condition tested."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/01/05 rogid:TjDU0GL+v84S+TwvRpJmF9CqhZ4559292 rogid:u4qztYWJIAVQOzZGnkLFnO3S2NA559292 rigid:vV2WkaDGuI7uyan6XTDM+sqcOrg false 35s radiolabel:?-? mutation with no effect:175-175,171-171|flag tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q12285 uniprotkb:P22214 intact:EBI-34904|uniprotkb:D6W1V6|ensemblfungi:YOL111C intact:EBI-16577|ensemblfungi:YLR268W|uniprotkb:D6VYR6 psi-mi:mdy2_yeast(display_long)|uniprotkb:MDY2(gene name)|psi-mi:MDY2(display_short)|uniprotkb:TMA24(gene name synonym)|uniprotkb:Mating-deficient protein 2(gene name synonym)|uniprotkb:Translation machinery-associated protein 24(gene name synonym)|uniprotkb:GET5(gene name synonym)|uniprotkb:Golgi to ER traffic protein 5(gene name synonym)|uniprotkb:YOL111C(locus name) psi-mi:sec22_yeast(display_long)|uniprotkb:SEC22(gene name)|psi-mi:SEC22(display_short)|uniprotkb:SLY2(gene name synonym)|uniprotkb:YLR268W(locus name)|uniprotkb:L8479.3(orf name)|uniprotkb:TSL26(gene name synonym)|uniprotkb:Suppressor of loss of YPT1 protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16718049|imex:IM-26462-47 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014530.1|sgd:S000005471|mint:Q12285|dip:DIP-1982N|ensemblfungi:YOL111C(gene)|ensemblfungi:YOL111C_mRNA(transcript)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR031765|interpro:IPR040474|rcsb pdb:2LNZ|rcsb pdb:2LXA|rcsb pdb:2LXC|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:3VEJ|rcsb pdb:3ZDM|rcsb pdb:4A20|rcsb pdb:4ASW|rcsb pdb:4GOC|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK refseq:NP_013370.1|sgd:S000004258|ensemblfungi:YLR268W(gene)|ensemblfungi:YLR268W_mRNA(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0048279"(vesicle fusion with endoplasmic reticulum)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|go:"GO:0000139"(Golgi membrane)|reactome:R-SCE-204005|reactome:R-SCE-5694530|reactome:R-SCE-6811434|dip:DIP-2234N - crc64:CE6FC4282E0E472C crc64:9FA3E34EAAFB9536 figure legend:Supp. Figs. 1B, 1E|comment:"Incubation of recombinant GET3 with GET4FLAG-SEC22 bound to anti-FLAG resin resulted in SEC22 elution This was abolished by three point mutations in GET3 (GET3 L187E, F190E, and I212E)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/01/05 rogid:lKhHoZ+UA1ZcX8TOoZMgJX+fzI0559292 rogid:TjDU0GL+v84S+TwvRpJmF9CqhZ4559292 rigid:Cm7NPwnNv7azA8L13VwqpZZNngs false flag tag:?-? 35s radiolabel:?-?|necessary binding region:188-214 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P40515 uniprotkb:Q12118 intact:EBI-25059|uniprotkb:D6VVL9|ensemblfungi:YIL065C intact:EBI-31784|uniprotkb:D6W273|ensemblfungi:YOR007C psi-mi:fis1_yeast(display_long)|uniprotkb:Mitochondrial division protein 2(gene name synonym)|uniprotkb:FIS1(gene name)|psi-mi:FIS1(display_short)|uniprotkb:MDV2(gene name synonym)|uniprotkb:YIL065C(locus name) psi-mi:sgt2_yeast(display_long)|uniprotkb:Viral protein U-binding protein(gene name synonym)|uniprotkb:SGT/UBP(gene name synonym)|uniprotkb:SGT2(gene name)|psi-mi:SGT2(display_short)|uniprotkb:UNF346(orf name)|uniprotkb:YOR007C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16718065|imex:IM-26462-33 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000001327|refseq:NP_012199.3|dip:DIP-1897N|reactome:R-SCE-9603798|ensemblfungi:YIL065C(gene)|ensemblfungi:YIL065C_mRNA(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005779"(integral component of peroxisomal membrane)|go:"GO:0007031"(peroxisome organization)|go:"GO:0016559"(peroxisome fission)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0090141"(positive regulation of mitochondrial fission)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016543(Tetratricopeptide repeat 11 Fission 1 protein)|interpro:IPR028058|interpro:IPR028061|interpro:IPR033745|rcsb pdb:1Y8M|rcsb pdb:2PQN|rcsb pdb:2PQR|rcsb pdb:3O48|rcsb pdb:3UUX refseq:NP_014649.1|sgd:S000005533|dip:DIP-1983N|mint:Q12118|ensemblfungi:YOR007C(gene)|ensemblfungi:YOR007C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072380"(TRC complex)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|rcsb pdb:2LXB|rcsb pdb:2LXC|rcsb pdb:3ZDM|rcsb pdb:4ASV|rcsb pdb:4ASW|rcsb pdb:5LYN|rcsb pdb:5LYP|reactome:R-SCE-9609523 - crc64:BD62D19524770536 crc64:33539B74F742BD3C figure legend:Fig. 4D|comment:Interaction observed in get5-/- cells|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/01/05 rogid:KRkQNanb9iSJ1rp+wV+XN4FqZDE559292 rogid:u4qztYWJIAVQOzZGnkLFnO3S2NA559292 rigid:W3eLtKXGPIgoomY+3GQc7LcenDI false 35s radiolabel:?-?|necessary binding region:132..132-149..149 mutation with no effect:171-171,175-175|flag tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P22214 uniprotkb:Q12154 intact:EBI-16577|ensemblfungi:YLR268W|uniprotkb:D6VYR6 intact:EBI-2989|uniprotkb:Q6B1B6|uniprotkb:D6VRQ0|ensemblfungi:YDL100C psi-mi:sec22_yeast(display_long)|uniprotkb:SEC22(gene name)|psi-mi:SEC22(display_short)|uniprotkb:SLY2(gene name synonym)|uniprotkb:YLR268W(locus name)|uniprotkb:L8479.3(orf name)|uniprotkb:TSL26(gene name synonym)|uniprotkb:Suppressor of loss of YPT1 protein 2(gene name synonym) psi-mi:get3_yeast(display_long)|uniprotkb:YDL100C(locus name)|uniprotkb:GET3(gene name)|psi-mi:GET3(display_short)|uniprotkb:ARR4(gene name synonym)|uniprotkb:D2371(orf name)|uniprotkb:Arsenical pump-driving ATPase(gene name synonym)|uniprotkb:Arsenite-stimulated ATPase(gene name synonym)|uniprotkb:Guided entry of tail-anchored proteins 3(gene name synonym)|uniprotkb:Golgi to ER traffic protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16718124|imex:IM-26462-35 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_013370.1|sgd:S000004258|ensemblfungi:YLR268W(gene)|ensemblfungi:YLR268W_mRNA(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0048279"(vesicle fusion with endoplasmic reticulum)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|go:"GO:0000139"(Golgi membrane)|reactome:R-SCE-204005|reactome:R-SCE-5694530|reactome:R-SCE-6811434|dip:DIP-2234N refseq:NP_010183.1|sgd:S000002258|dip:DIP-3908N|mint:Q12154|ensemblfungi:YDL100C(gene)|ensemblfungi:YDL100C_mRNA(transcript)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0009408"(response to heat)|go:"GO:0010038"(response to metal ion)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043529"(GET complex)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1990507"(obsolete ATP-independent chaperone mediated protein folding)|interpro:IPR016300(Arsenite-transporting ATPase)|interpro:IPR025723|interpro:IPR027417|interpro:IPR027542|rcsb pdb:2WOJ|rcsb pdb:3A36|rcsb pdb:3A37|rcsb pdb:3B2E|rcsb pdb:3H84|rcsb pdb:3IDQ|rcsb pdb:3SJA|rcsb pdb:3SJB|rcsb pdb:3SJC|rcsb pdb:3SJD|rcsb pdb:3VLC|rcsb pdb:3ZS8|rcsb pdb:3ZS9|rcsb pdb:4PWX|rcsb pdb:4XTR|rcsb pdb:4XVU|rcsb pdb:4XWO|rcsb pdb:5BW8|rcsb pdb:5BWK - crc64:9FA3E34EAAFB9536 crc64:F795C359B5A4A461 figure legend:Supp. Figs. 4C|comment:GET3 was first incubated with Flag-tagged SGT2 in get3/5-/- cell lysate, isolated by anti-flag tag immunoprecipitation, then by anti-His. The complex was eluted on addition of untagged GET£.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/01/05 rogid:TjDU0GL+v84S+TwvRpJmF9CqhZ4559292 rogid:Y+PTDg+beVeCH5mn4BvWi5wBP4A559292 rigid:3yxprKMj/RR9uIH+rpgZ34iWqBI false 35s radiolabel:?-? his tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q12154 uniprotkb:Q12118 intact:EBI-2989|uniprotkb:Q6B1B6|uniprotkb:D6VRQ0|ensemblfungi:YDL100C intact:EBI-31784|uniprotkb:D6W273|ensemblfungi:YOR007C psi-mi:get3_yeast(display_long)|uniprotkb:YDL100C(locus name)|uniprotkb:GET3(gene name)|psi-mi:GET3(display_short)|uniprotkb:ARR4(gene name synonym)|uniprotkb:D2371(orf name)|uniprotkb:Arsenical pump-driving ATPase(gene name synonym)|uniprotkb:Arsenite-stimulated ATPase(gene name synonym)|uniprotkb:Guided entry of tail-anchored proteins 3(gene name synonym)|uniprotkb:Golgi to ER traffic protein 3(gene name synonym) psi-mi:sgt2_yeast(display_long)|uniprotkb:Viral protein U-binding protein(gene name synonym)|uniprotkb:SGT/UBP(gene name synonym)|uniprotkb:SGT2(gene name)|psi-mi:SGT2(display_short)|uniprotkb:UNF346(orf name)|uniprotkb:YOR007C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16718015|imex:IM-26462-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010183.1|sgd:S000002258|dip:DIP-3908N|mint:Q12154|ensemblfungi:YDL100C(gene)|ensemblfungi:YDL100C_mRNA(transcript)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0009408"(response to heat)|go:"GO:0010038"(response to metal ion)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043529"(GET complex)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1990507"(obsolete ATP-independent chaperone mediated protein folding)|interpro:IPR016300(Arsenite-transporting ATPase)|interpro:IPR025723|interpro:IPR027417|interpro:IPR027542|rcsb pdb:2WOJ|rcsb pdb:3A36|rcsb pdb:3A37|rcsb pdb:3B2E|rcsb pdb:3H84|rcsb pdb:3IDQ|rcsb pdb:3SJA|rcsb pdb:3SJB|rcsb pdb:3SJC|rcsb pdb:3SJD|rcsb pdb:3VLC|rcsb pdb:3ZS8|rcsb pdb:3ZS9|rcsb pdb:4PWX|rcsb pdb:4XTR|rcsb pdb:4XVU|rcsb pdb:4XWO|rcsb pdb:5BW8|rcsb pdb:5BWK refseq:NP_014649.1|sgd:S000005533|dip:DIP-1983N|mint:Q12118|ensemblfungi:YOR007C(gene)|ensemblfungi:YOR007C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072380"(TRC complex)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|rcsb pdb:2LXB|rcsb pdb:2LXC|rcsb pdb:3ZDM|rcsb pdb:4ASV|rcsb pdb:4ASW|rcsb pdb:5LYN|rcsb pdb:5LYP|reactome:R-SCE-9609523 - crc64:F795C359B5A4A461 crc64:33539B74F742BD3C figure legend:Fig. 6B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/01/05 rogid:Y+PTDg+beVeCH5mn4BvWi5wBP4A559292 rogid:u4qztYWJIAVQOzZGnkLFnO3S2NA559292 rigid:iYJ6Yy9JzwKU4LezV5P9B0X13dA false flag tag:?-? sufficient binding region:1-208 - - psi-mi:"MI:0820"(molecular weight estimation by sybr staining) psi-mi:"MI:0820"(molecular weight estimation by sybr staining) uniprotkb:Q12154 uniprotkb:Q12285 intact:EBI-2989|uniprotkb:Q6B1B6|uniprotkb:D6VRQ0|ensemblfungi:YDL100C intact:EBI-34904|uniprotkb:D6W1V6|ensemblfungi:YOL111C psi-mi:get3_yeast(display_long)|uniprotkb:YDL100C(locus name)|uniprotkb:GET3(gene name)|psi-mi:GET3(display_short)|uniprotkb:ARR4(gene name synonym)|uniprotkb:D2371(orf name)|uniprotkb:Arsenical pump-driving ATPase(gene name synonym)|uniprotkb:Arsenite-stimulated ATPase(gene name synonym)|uniprotkb:Guided entry of tail-anchored proteins 3(gene name synonym)|uniprotkb:Golgi to ER traffic protein 3(gene name synonym) psi-mi:mdy2_yeast(display_long)|uniprotkb:MDY2(gene name)|psi-mi:MDY2(display_short)|uniprotkb:TMA24(gene name synonym)|uniprotkb:Mating-deficient protein 2(gene name synonym)|uniprotkb:Translation machinery-associated protein 24(gene name synonym)|uniprotkb:GET5(gene name synonym)|uniprotkb:Golgi to ER traffic protein 5(gene name synonym)|uniprotkb:YOL111C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16718015|imex:IM-26462-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010183.1|sgd:S000002258|dip:DIP-3908N|mint:Q12154|ensemblfungi:YDL100C(gene)|ensemblfungi:YDL100C_mRNA(transcript)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0009408"(response to heat)|go:"GO:0010038"(response to metal ion)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043529"(GET complex)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1990507"(obsolete ATP-independent chaperone mediated protein folding)|interpro:IPR016300(Arsenite-transporting ATPase)|interpro:IPR025723|interpro:IPR027417|interpro:IPR027542|rcsb pdb:2WOJ|rcsb pdb:3A36|rcsb pdb:3A37|rcsb pdb:3B2E|rcsb pdb:3H84|rcsb pdb:3IDQ|rcsb pdb:3SJA|rcsb pdb:3SJB|rcsb pdb:3SJC|rcsb pdb:3SJD|rcsb pdb:3VLC|rcsb pdb:3ZS8|rcsb pdb:3ZS9|rcsb pdb:4PWX|rcsb pdb:4XTR|rcsb pdb:4XVU|rcsb pdb:4XWO|rcsb pdb:5BW8|rcsb pdb:5BWK refseq:NP_014530.1|sgd:S000005471|mint:Q12285|dip:DIP-1982N|ensemblfungi:YOL111C(gene)|ensemblfungi:YOL111C_mRNA(transcript)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR031765|interpro:IPR040474|rcsb pdb:2LNZ|rcsb pdb:2LXA|rcsb pdb:2LXC|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:3VEJ|rcsb pdb:3ZDM|rcsb pdb:4A20|rcsb pdb:4ASW|rcsb pdb:4GOC|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK - crc64:F795C359B5A4A461 crc64:CE6FC4282E0E472C figure legend:Fig. 6B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/01/05 rogid:Y+PTDg+beVeCH5mn4BvWi5wBP4A559292 rogid:lKhHoZ+UA1ZcX8TOoZMgJX+fzI0559292 rigid:iYJ6Yy9JzwKU4LezV5P9B0X13dA false flag tag:?-? - - - psi-mi:"MI:0820"(molecular weight estimation by sybr staining) psi-mi:"MI:0820"(molecular weight estimation by sybr staining) uniprotkb:Q12154 uniprotkb:Q12125 intact:EBI-2989|uniprotkb:Q6B1B6|uniprotkb:D6VRQ0|ensemblfungi:YDL100C intact:EBI-36940|uniprotkb:D6W2M2|ensemblfungi:YOR164C psi-mi:get3_yeast(display_long)|uniprotkb:YDL100C(locus name)|uniprotkb:GET3(gene name)|psi-mi:GET3(display_short)|uniprotkb:ARR4(gene name synonym)|uniprotkb:D2371(orf name)|uniprotkb:Arsenical pump-driving ATPase(gene name synonym)|uniprotkb:Arsenite-stimulated ATPase(gene name synonym)|uniprotkb:Guided entry of tail-anchored proteins 3(gene name synonym)|uniprotkb:Golgi to ER traffic protein 3(gene name synonym) psi-mi:get4_yeast(display_long)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:O3580(orf name)|uniprotkb:YOR164C(locus name)|uniprotkb:Guided entry of tail-anchored proteins 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16718015|imex:IM-26462-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010183.1|sgd:S000002258|dip:DIP-3908N|mint:Q12154|ensemblfungi:YDL100C(gene)|ensemblfungi:YDL100C_mRNA(transcript)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0009408"(response to heat)|go:"GO:0010038"(response to metal ion)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043529"(GET complex)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1990507"(obsolete ATP-independent chaperone mediated protein folding)|interpro:IPR016300(Arsenite-transporting ATPase)|interpro:IPR025723|interpro:IPR027417|interpro:IPR027542|rcsb pdb:2WOJ|rcsb pdb:3A36|rcsb pdb:3A37|rcsb pdb:3B2E|rcsb pdb:3H84|rcsb pdb:3IDQ|rcsb pdb:3SJA|rcsb pdb:3SJB|rcsb pdb:3SJC|rcsb pdb:3SJD|rcsb pdb:3VLC|rcsb pdb:3ZS8|rcsb pdb:3ZS9|rcsb pdb:4PWX|rcsb pdb:4XTR|rcsb pdb:4XVU|rcsb pdb:4XWO|rcsb pdb:5BW8|rcsb pdb:5BWK sgd:S000005690|refseq:NP_014807.3|mint:Q12125|dip:DIP-2005N|ensemblfungi:YOR164C(gene)|ensemblfungi:YOR164C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK - crc64:F795C359B5A4A461 crc64:98AFFDB4EA51B40F figure legend:Fig. 6B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/01/05 rogid:Y+PTDg+beVeCH5mn4BvWi5wBP4A559292 rogid:t1xcIrahizw7d4/IGrx82rIEkOU559292 rigid:iYJ6Yy9JzwKU4LezV5P9B0X13dA false flag tag:?-? - - - psi-mi:"MI:0820"(molecular weight estimation by sybr staining) psi-mi:"MI:0820"(molecular weight estimation by sybr staining) uniprotkb:Q12154 uniprotkb:Q12285 intact:EBI-2989|uniprotkb:Q6B1B6|uniprotkb:D6VRQ0|ensemblfungi:YDL100C intact:EBI-34904|uniprotkb:D6W1V6|ensemblfungi:YOL111C psi-mi:get3_yeast(display_long)|uniprotkb:YDL100C(locus name)|uniprotkb:GET3(gene name)|psi-mi:GET3(display_short)|uniprotkb:ARR4(gene name synonym)|uniprotkb:D2371(orf name)|uniprotkb:Arsenical pump-driving ATPase(gene name synonym)|uniprotkb:Arsenite-stimulated ATPase(gene name synonym)|uniprotkb:Guided entry of tail-anchored proteins 3(gene name synonym)|uniprotkb:Golgi to ER traffic protein 3(gene name synonym) psi-mi:mdy2_yeast(display_long)|uniprotkb:MDY2(gene name)|psi-mi:MDY2(display_short)|uniprotkb:TMA24(gene name synonym)|uniprotkb:Mating-deficient protein 2(gene name synonym)|uniprotkb:Translation machinery-associated protein 24(gene name synonym)|uniprotkb:GET5(gene name synonym)|uniprotkb:Golgi to ER traffic protein 5(gene name synonym)|uniprotkb:YOL111C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16718035|imex:IM-26462-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010183.1|sgd:S000002258|dip:DIP-3908N|mint:Q12154|ensemblfungi:YDL100C(gene)|ensemblfungi:YDL100C_mRNA(transcript)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0009408"(response to heat)|go:"GO:0010038"(response to metal ion)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043529"(GET complex)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1990507"(obsolete ATP-independent chaperone mediated protein folding)|interpro:IPR016300(Arsenite-transporting ATPase)|interpro:IPR025723|interpro:IPR027417|interpro:IPR027542|rcsb pdb:2WOJ|rcsb pdb:3A36|rcsb pdb:3A37|rcsb pdb:3B2E|rcsb pdb:3H84|rcsb pdb:3IDQ|rcsb pdb:3SJA|rcsb pdb:3SJB|rcsb pdb:3SJC|rcsb pdb:3SJD|rcsb pdb:3VLC|rcsb pdb:3ZS8|rcsb pdb:3ZS9|rcsb pdb:4PWX|rcsb pdb:4XTR|rcsb pdb:4XVU|rcsb pdb:4XWO|rcsb pdb:5BW8|rcsb pdb:5BWK refseq:NP_014530.1|sgd:S000005471|mint:Q12285|dip:DIP-1982N|ensemblfungi:YOL111C(gene)|ensemblfungi:YOL111C_mRNA(transcript)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR031765|interpro:IPR040474|rcsb pdb:2LNZ|rcsb pdb:2LXA|rcsb pdb:2LXC|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:3VEJ|rcsb pdb:3ZDM|rcsb pdb:4A20|rcsb pdb:4ASW|rcsb pdb:4GOC|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK - crc64:F795C359B5A4A461 crc64:CE6FC4282E0E472C figure legend:Fig. 6B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/01/05 rogid:Y+PTDg+beVeCH5mn4BvWi5wBP4A559292 rogid:lKhHoZ+UA1ZcX8TOoZMgJX+fzI0559292 rigid:pAtTWkWjsXdxP6ZRGonxYwOZuU0 false flag tag:?-? - - - psi-mi:"MI:0820"(molecular weight estimation by sybr staining) psi-mi:"MI:0820"(molecular weight estimation by sybr staining) uniprotkb:Q12154 uniprotkb:Q12125 intact:EBI-2989|uniprotkb:Q6B1B6|uniprotkb:D6VRQ0|ensemblfungi:YDL100C intact:EBI-36940|uniprotkb:D6W2M2|ensemblfungi:YOR164C psi-mi:get3_yeast(display_long)|uniprotkb:YDL100C(locus name)|uniprotkb:GET3(gene name)|psi-mi:GET3(display_short)|uniprotkb:ARR4(gene name synonym)|uniprotkb:D2371(orf name)|uniprotkb:Arsenical pump-driving ATPase(gene name synonym)|uniprotkb:Arsenite-stimulated ATPase(gene name synonym)|uniprotkb:Guided entry of tail-anchored proteins 3(gene name synonym)|uniprotkb:Golgi to ER traffic protein 3(gene name synonym) psi-mi:get4_yeast(display_long)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:O3580(orf name)|uniprotkb:YOR164C(locus name)|uniprotkb:Guided entry of tail-anchored proteins 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16718035|imex:IM-26462-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010183.1|sgd:S000002258|dip:DIP-3908N|mint:Q12154|ensemblfungi:YDL100C(gene)|ensemblfungi:YDL100C_mRNA(transcript)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0009408"(response to heat)|go:"GO:0010038"(response to metal ion)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043529"(GET complex)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1990507"(obsolete ATP-independent chaperone mediated protein folding)|interpro:IPR016300(Arsenite-transporting ATPase)|interpro:IPR025723|interpro:IPR027417|interpro:IPR027542|rcsb pdb:2WOJ|rcsb pdb:3A36|rcsb pdb:3A37|rcsb pdb:3B2E|rcsb pdb:3H84|rcsb pdb:3IDQ|rcsb pdb:3SJA|rcsb pdb:3SJB|rcsb pdb:3SJC|rcsb pdb:3SJD|rcsb pdb:3VLC|rcsb pdb:3ZS8|rcsb pdb:3ZS9|rcsb pdb:4PWX|rcsb pdb:4XTR|rcsb pdb:4XVU|rcsb pdb:4XWO|rcsb pdb:5BW8|rcsb pdb:5BWK sgd:S000005690|refseq:NP_014807.3|mint:Q12125|dip:DIP-2005N|ensemblfungi:YOR164C(gene)|ensemblfungi:YOR164C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK - crc64:F795C359B5A4A461 crc64:98AFFDB4EA51B40F figure legend:Fig. 6B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/01/05 rogid:Y+PTDg+beVeCH5mn4BvWi5wBP4A559292 rogid:t1xcIrahizw7d4/IGrx82rIEkOU559292 rigid:pAtTWkWjsXdxP6ZRGonxYwOZuU0 false flag tag:?-? - - - psi-mi:"MI:0820"(molecular weight estimation by sybr staining) psi-mi:"MI:0820"(molecular weight estimation by sybr staining) uniprotkb:P31539 uniprotkb:Q12285 intact:EBI-8050|uniprotkb:D6VXX8|ensemblfungi:YLL026W intact:EBI-34904|uniprotkb:D6W1V6|ensemblfungi:YOL111C psi-mi:hs104_yeast(display_long)|uniprotkb:HSP104(gene name)|psi-mi:HSP104(display_short)|uniprotkb:YLL026W(locus name)|uniprotkb:L0948(orf name)|uniprotkb:Protein aggregation-remodeling factor HSP104(gene name synonym) psi-mi:mdy2_yeast(display_long)|uniprotkb:MDY2(gene name)|psi-mi:MDY2(display_short)|uniprotkb:TMA24(gene name synonym)|uniprotkb:Mating-deficient protein 2(gene name synonym)|uniprotkb:Translation machinery-associated protein 24(gene name synonym)|uniprotkb:GET5(gene name synonym)|uniprotkb:Golgi to ER traffic protein 5(gene name synonym)|uniprotkb:YOL111C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16718106|imex:IM-26462-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000003949|refseq:NP_013074.1|mint:P31539|dip:DIP-2252N|ensemblfungi:YLL026W(gene)|ensemblfungi:YLL026W_mRNA(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0042026"(protein refolding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043335"(protein unfolding)|go:"GO:0043531"(ADP binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070370"(cellular heat acclimation)|go:"GO:0070414"(trehalose metabolism in response to heat stress)|go:"GO:0072380"(TRC complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004176(Clp, N-terminal)|interpro:IPR018368|interpro:IPR019489|interpro:IPR027417|interpro:IPR028299|interpro:IPR036628|interpro:IPR041546|rcsb pdb:5KNE|rcsb pdb:5U2U|rcsb pdb:5VJH|rcsb pdb:5VY8|rcsb pdb:5VY9|rcsb pdb:5VYA|rcsb pdb:5WBW|rcsb pdb:6AHF|rcsb pdb:6AMN|rcsb pdb:6N8T|rcsb pdb:6N8V|rcsb pdb:6N8Z refseq:NP_014530.1|sgd:S000005471|mint:Q12285|dip:DIP-1982N|ensemblfungi:YOL111C(gene)|ensemblfungi:YOL111C_mRNA(transcript)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR031765|interpro:IPR040474|rcsb pdb:2LNZ|rcsb pdb:2LXA|rcsb pdb:2LXC|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:3VEJ|rcsb pdb:3ZDM|rcsb pdb:4A20|rcsb pdb:4ASW|rcsb pdb:4GOC|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK - crc64:4AD0E7E3AF98E318 crc64:CE6FC4282E0E472C figure legend:Supp. Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/11/15 2018/01/05 rogid:rMl56qonOOODJUyLVkkWwUq8Cj4559292 rogid:lKhHoZ+UA1ZcX8TOoZMgJX+fzI0559292 rigid:FtBtth5rG1ks753/TjCp8mxhjV4 false necessary binding region:193-198 flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q12125 uniprotkb:Q12118 intact:EBI-36940|uniprotkb:D6W2M2|ensemblfungi:YOR164C intact:EBI-31784|uniprotkb:D6W273|ensemblfungi:YOR007C psi-mi:get4_yeast(display_long)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:O3580(orf name)|uniprotkb:YOR164C(locus name)|uniprotkb:Guided entry of tail-anchored proteins 4(gene name synonym) psi-mi:sgt2_yeast(display_long)|uniprotkb:Viral protein U-binding protein(gene name synonym)|uniprotkb:SGT/UBP(gene name synonym)|uniprotkb:SGT2(gene name)|psi-mi:SGT2(display_short)|uniprotkb:UNF346(orf name)|uniprotkb:YOR007C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16718114|imex:IM-26462-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000005690|refseq:NP_014807.3|mint:Q12125|dip:DIP-2005N|ensemblfungi:YOR164C(gene)|ensemblfungi:YOR164C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK refseq:NP_014649.1|sgd:S000005533|dip:DIP-1983N|mint:Q12118|ensemblfungi:YOR007C(gene)|ensemblfungi:YOR007C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072380"(TRC complex)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|rcsb pdb:2LXB|rcsb pdb:2LXC|rcsb pdb:3ZDM|rcsb pdb:4ASV|rcsb pdb:4ASW|rcsb pdb:5LYN|rcsb pdb:5LYP|reactome:R-SCE-9609523 - crc64:98AFFDB4EA51B40F crc64:33539B74F742BD3C figure legend:Supp. Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/11/15 2018/01/05 rogid:t1xcIrahizw7d4/IGrx82rIEkOU559292 rogid:u4qztYWJIAVQOzZGnkLFnO3S2NA559292 rigid:ZS86snqj2uC+vOdw2jAb1ja58Ic false myc tag:?-? flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q12154 uniprotkb:P22214 intact:EBI-2989|uniprotkb:Q6B1B6|uniprotkb:D6VRQ0|ensemblfungi:YDL100C intact:EBI-16577|ensemblfungi:YLR268W|uniprotkb:D6VYR6 psi-mi:get3_yeast(display_long)|uniprotkb:YDL100C(locus name)|uniprotkb:GET3(gene name)|psi-mi:GET3(display_short)|uniprotkb:ARR4(gene name synonym)|uniprotkb:D2371(orf name)|uniprotkb:Arsenical pump-driving ATPase(gene name synonym)|uniprotkb:Arsenite-stimulated ATPase(gene name synonym)|uniprotkb:Guided entry of tail-anchored proteins 3(gene name synonym)|uniprotkb:Golgi to ER traffic protein 3(gene name synonym) psi-mi:sec22_yeast(display_long)|uniprotkb:SEC22(gene name)|psi-mi:SEC22(display_short)|uniprotkb:SLY2(gene name synonym)|uniprotkb:YLR268W(locus name)|uniprotkb:L8479.3(orf name)|uniprotkb:TSL26(gene name synonym)|uniprotkb:Suppressor of loss of YPT1 protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16718161|imex:IM-26462-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010183.1|sgd:S000002258|dip:DIP-3908N|mint:Q12154|ensemblfungi:YDL100C(gene)|ensemblfungi:YDL100C_mRNA(transcript)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0009408"(response to heat)|go:"GO:0010038"(response to metal ion)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043529"(GET complex)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1990507"(obsolete ATP-independent chaperone mediated protein folding)|interpro:IPR016300(Arsenite-transporting ATPase)|interpro:IPR025723|interpro:IPR027417|interpro:IPR027542|rcsb pdb:2WOJ|rcsb pdb:3A36|rcsb pdb:3A37|rcsb pdb:3B2E|rcsb pdb:3H84|rcsb pdb:3IDQ|rcsb pdb:3SJA|rcsb pdb:3SJB|rcsb pdb:3SJC|rcsb pdb:3SJD|rcsb pdb:3VLC|rcsb pdb:3ZS8|rcsb pdb:3ZS9|rcsb pdb:4PWX|rcsb pdb:4XTR|rcsb pdb:4XVU|rcsb pdb:4XWO|rcsb pdb:5BW8|rcsb pdb:5BWK refseq:NP_013370.1|sgd:S000004258|ensemblfungi:YLR268W(gene)|ensemblfungi:YLR268W_mRNA(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0048279"(vesicle fusion with endoplasmic reticulum)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|go:"GO:0000139"(Golgi membrane)|reactome:R-SCE-204005|reactome:R-SCE-5694530|reactome:R-SCE-6811434|dip:DIP-2234N - crc64:F795C359B5A4A461 crc64:9FA3E34EAAFB9536 figure legend:Supp. Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/07/12 rogid:Y+PTDg+beVeCH5mn4BvWi5wBP4A559292 rogid:TjDU0GL+v84S+TwvRpJmF9CqhZ4559292 rigid:qzi2fro/TeV8juqN4vL85G4wJ94 false flag tag:?-? necessary binding region:188-213|35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q12154 uniprotkb:Q12306 intact:EBI-2989|uniprotkb:Q6B1B6|uniprotkb:D6VRQ0|ensemblfungi:YDL100C intact:EBI-17490|uniprotkb:D6VTD1|ensemblfungi:YDR510W psi-mi:get3_yeast(display_long)|uniprotkb:YDL100C(locus name)|uniprotkb:GET3(gene name)|psi-mi:GET3(display_short)|uniprotkb:ARR4(gene name synonym)|uniprotkb:D2371(orf name)|uniprotkb:Arsenical pump-driving ATPase(gene name synonym)|uniprotkb:Arsenite-stimulated ATPase(gene name synonym)|uniprotkb:Guided entry of tail-anchored proteins 3(gene name synonym)|uniprotkb:Golgi to ER traffic protein 3(gene name synonym) psi-mi:smt3_yeast(display_long)|uniprotkb:SMT3(gene name)|psi-mi:SMT3(display_short)|uniprotkb:D9719.15(orf name)|uniprotkb:YDR510W(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16718161|imex:IM-26462-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010183.1|sgd:S000002258|dip:DIP-3908N|mint:Q12154|ensemblfungi:YDL100C(gene)|ensemblfungi:YDL100C_mRNA(transcript)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0009408"(response to heat)|go:"GO:0010038"(response to metal ion)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043529"(GET complex)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1990507"(obsolete ATP-independent chaperone mediated protein folding)|interpro:IPR016300(Arsenite-transporting ATPase)|interpro:IPR025723|interpro:IPR027417|interpro:IPR027542|rcsb pdb:2WOJ|rcsb pdb:3A36|rcsb pdb:3A37|rcsb pdb:3B2E|rcsb pdb:3H84|rcsb pdb:3IDQ|rcsb pdb:3SJA|rcsb pdb:3SJB|rcsb pdb:3SJC|rcsb pdb:3SJD|rcsb pdb:3VLC|rcsb pdb:3ZS8|rcsb pdb:3ZS9|rcsb pdb:4PWX|rcsb pdb:4XTR|rcsb pdb:4XVU|rcsb pdb:4XWO|rcsb pdb:5BW8|rcsb pdb:5BWK refseq:NP_010798.1|sgd:S000002918|ensemblfungi:YDR510W(gene)|ensemblfungi:YDR510W_mRNA(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005940"(septin ring)|go:"GO:0016925"(protein sumoylation)|go:"GO:0031386"(protein tag)|go:"GO:0042802"(identical protein binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|rcsb pdb:1EUV|rcsb pdb:1L2N|rcsb pdb:2EKE|rcsb pdb:3PGE|rcsb pdb:3QHT|rcsb pdb:3TIX|rcsb pdb:3UF8|rcsb pdb:3UQA|rcsb pdb:3UQB|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:3VAW|rcsb pdb:4FN2|rcsb pdb:4G50|rcsb pdb:4GGQ|rcsb pdb:4GIV|rcsb pdb:5D6J|rcsb pdb:5JNE|rcsb pdb:5KLX|rcsb pdb:5V8T|rcsb pdb:5YC2|rcsb pdb:5YCA|rcsb pdb:6CFP|rcsb pdb:6P81|rcsb pdb:6Q2S|rcsb pdb:6RPQ|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:6UKV|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6VEL|rcsb pdb:6VW2|rcsb pdb:7LTO|reactome:R-SCE-3065676|reactome:R-SCE-3065678|reactome:R-SCE-3065679|reactome:R-SCE-3108214|reactome:R-SCE-3108232|reactome:R-SCE-3232118|reactome:R-SCE-3899300|reactome:R-SCE-4085377|reactome:R-SCE-4551638|reactome:R-SCE-4570464|reactome:R-SCE-4615885|reactome:R-SCE-9615933|dip:DIP-1364N|mint:Q12306 - crc64:F795C359B5A4A461 crc64:A2790DE7F315E1A7 figure legend:Supp. Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/07/12 rogid:Y+PTDg+beVeCH5mn4BvWi5wBP4A559292 rogid:oFdVBxN9WlDXTM7oAnv+1vfcXFQ559292 rigid:qzi2fro/TeV8juqN4vL85G4wJ94 false flag tag:?-? tag:?-?|binding-associated region:?-?|35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q12125 uniprotkb:P22214 intact:EBI-36940|uniprotkb:D6W2M2|ensemblfungi:YOR164C intact:EBI-16577|ensemblfungi:YLR268W|uniprotkb:D6VYR6 psi-mi:get4_yeast(display_long)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:O3580(orf name)|uniprotkb:YOR164C(locus name)|uniprotkb:Guided entry of tail-anchored proteins 4(gene name synonym) psi-mi:sec22_yeast(display_long)|uniprotkb:SEC22(gene name)|psi-mi:SEC22(display_short)|uniprotkb:SLY2(gene name synonym)|uniprotkb:YLR268W(locus name)|uniprotkb:L8479.3(orf name)|uniprotkb:TSL26(gene name synonym)|uniprotkb:Suppressor of loss of YPT1 protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16718176|imex:IM-26462-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000005690|refseq:NP_014807.3|mint:Q12125|dip:DIP-2005N|ensemblfungi:YOR164C(gene)|ensemblfungi:YOR164C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK refseq:NP_013370.1|sgd:S000004258|ensemblfungi:YLR268W(gene)|ensemblfungi:YLR268W_mRNA(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0048279"(vesicle fusion with endoplasmic reticulum)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|go:"GO:0000139"(Golgi membrane)|reactome:R-SCE-204005|reactome:R-SCE-5694530|reactome:R-SCE-6811434|dip:DIP-2234N - crc64:98AFFDB4EA51B40F crc64:9FA3E34EAAFB9536 figure legend:Supp. Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/07/12 rogid:t1xcIrahizw7d4/IGrx82rIEkOU559292 rogid:TjDU0GL+v84S+TwvRpJmF9CqhZ4559292 rigid:BSSEI39KPh53WsXpv0OtL1biGLw false flag tag:?-? necessary binding region:188-213|35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q12125 uniprotkb:Q12306 intact:EBI-36940|uniprotkb:D6W2M2|ensemblfungi:YOR164C intact:EBI-17490|uniprotkb:D6VTD1|ensemblfungi:YDR510W psi-mi:get4_yeast(display_long)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:O3580(orf name)|uniprotkb:YOR164C(locus name)|uniprotkb:Guided entry of tail-anchored proteins 4(gene name synonym) psi-mi:smt3_yeast(display_long)|uniprotkb:SMT3(gene name)|psi-mi:SMT3(display_short)|uniprotkb:D9719.15(orf name)|uniprotkb:YDR510W(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16718176|imex:IM-26462-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000005690|refseq:NP_014807.3|mint:Q12125|dip:DIP-2005N|ensemblfungi:YOR164C(gene)|ensemblfungi:YOR164C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK refseq:NP_010798.1|sgd:S000002918|ensemblfungi:YDR510W(gene)|ensemblfungi:YDR510W_mRNA(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005940"(septin ring)|go:"GO:0016925"(protein sumoylation)|go:"GO:0031386"(protein tag)|go:"GO:0042802"(identical protein binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|rcsb pdb:1EUV|rcsb pdb:1L2N|rcsb pdb:2EKE|rcsb pdb:3PGE|rcsb pdb:3QHT|rcsb pdb:3TIX|rcsb pdb:3UF8|rcsb pdb:3UQA|rcsb pdb:3UQB|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:3VAW|rcsb pdb:4FN2|rcsb pdb:4G50|rcsb pdb:4GGQ|rcsb pdb:4GIV|rcsb pdb:5D6J|rcsb pdb:5JNE|rcsb pdb:5KLX|rcsb pdb:5V8T|rcsb pdb:5YC2|rcsb pdb:5YCA|rcsb pdb:6CFP|rcsb pdb:6P81|rcsb pdb:6Q2S|rcsb pdb:6RPQ|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:6UKV|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6VEL|rcsb pdb:6VW2|rcsb pdb:7LTO|reactome:R-SCE-3065676|reactome:R-SCE-3065678|reactome:R-SCE-3065679|reactome:R-SCE-3108214|reactome:R-SCE-3108232|reactome:R-SCE-3232118|reactome:R-SCE-3899300|reactome:R-SCE-4085377|reactome:R-SCE-4551638|reactome:R-SCE-4570464|reactome:R-SCE-4615885|reactome:R-SCE-9615933|dip:DIP-1364N|mint:Q12306 - crc64:98AFFDB4EA51B40F crc64:A2790DE7F315E1A7 figure legend:Supp. Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/07/12 rogid:t1xcIrahizw7d4/IGrx82rIEkOU559292 rogid:oFdVBxN9WlDXTM7oAnv+1vfcXFQ559292 rigid:BSSEI39KPh53WsXpv0OtL1biGLw false flag tag:?-? tag:?-?|binding-associated region:?-?|35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q12285 uniprotkb:P22214 intact:EBI-34904|uniprotkb:D6W1V6|ensemblfungi:YOL111C intact:EBI-16577|ensemblfungi:YLR268W|uniprotkb:D6VYR6 psi-mi:mdy2_yeast(display_long)|uniprotkb:MDY2(gene name)|psi-mi:MDY2(display_short)|uniprotkb:TMA24(gene name synonym)|uniprotkb:Mating-deficient protein 2(gene name synonym)|uniprotkb:Translation machinery-associated protein 24(gene name synonym)|uniprotkb:GET5(gene name synonym)|uniprotkb:Golgi to ER traffic protein 5(gene name synonym)|uniprotkb:YOL111C(locus name) psi-mi:sec22_yeast(display_long)|uniprotkb:SEC22(gene name)|psi-mi:SEC22(display_short)|uniprotkb:SLY2(gene name synonym)|uniprotkb:YLR268W(locus name)|uniprotkb:L8479.3(orf name)|uniprotkb:TSL26(gene name synonym)|uniprotkb:Suppressor of loss of YPT1 protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16718189|imex:IM-26462-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014530.1|sgd:S000005471|mint:Q12285|dip:DIP-1982N|ensemblfungi:YOL111C(gene)|ensemblfungi:YOL111C_mRNA(transcript)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR031765|interpro:IPR040474|rcsb pdb:2LNZ|rcsb pdb:2LXA|rcsb pdb:2LXC|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:3VEJ|rcsb pdb:3ZDM|rcsb pdb:4A20|rcsb pdb:4ASW|rcsb pdb:4GOC|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK refseq:NP_013370.1|sgd:S000004258|ensemblfungi:YLR268W(gene)|ensemblfungi:YLR268W_mRNA(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0048279"(vesicle fusion with endoplasmic reticulum)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|go:"GO:0000139"(Golgi membrane)|reactome:R-SCE-204005|reactome:R-SCE-5694530|reactome:R-SCE-6811434|dip:DIP-2234N - crc64:CE6FC4282E0E472C crc64:9FA3E34EAAFB9536 figure legend:Supp. Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/01/05 rogid:lKhHoZ+UA1ZcX8TOoZMgJX+fzI0559292 rogid:TjDU0GL+v84S+TwvRpJmF9CqhZ4559292 rigid:FQfI+45VCeYUScAHFeJoDByW9FI false flag tag:?-? necessary binding region:188-213|35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q12285 uniprotkb:Q12306 intact:EBI-34904|uniprotkb:D6W1V6|ensemblfungi:YOL111C intact:EBI-17490|uniprotkb:D6VTD1|ensemblfungi:YDR510W psi-mi:mdy2_yeast(display_long)|uniprotkb:MDY2(gene name)|psi-mi:MDY2(display_short)|uniprotkb:TMA24(gene name synonym)|uniprotkb:Mating-deficient protein 2(gene name synonym)|uniprotkb:Translation machinery-associated protein 24(gene name synonym)|uniprotkb:GET5(gene name synonym)|uniprotkb:Golgi to ER traffic protein 5(gene name synonym)|uniprotkb:YOL111C(locus name) psi-mi:smt3_yeast(display_long)|uniprotkb:SMT3(gene name)|psi-mi:SMT3(display_short)|uniprotkb:D9719.15(orf name)|uniprotkb:YDR510W(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16718189|imex:IM-26462-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014530.1|sgd:S000005471|mint:Q12285|dip:DIP-1982N|ensemblfungi:YOL111C(gene)|ensemblfungi:YOL111C_mRNA(transcript)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR031765|interpro:IPR040474|rcsb pdb:2LNZ|rcsb pdb:2LXA|rcsb pdb:2LXC|rcsb pdb:2WPV|rcsb pdb:3LKU|rcsb pdb:3VEJ|rcsb pdb:3ZDM|rcsb pdb:4A20|rcsb pdb:4ASW|rcsb pdb:4GOC|rcsb pdb:4PWX|rcsb pdb:5BW8|rcsb pdb:5BWK refseq:NP_010798.1|sgd:S000002918|ensemblfungi:YDR510W(gene)|ensemblfungi:YDR510W_mRNA(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005940"(septin ring)|go:"GO:0016925"(protein sumoylation)|go:"GO:0031386"(protein tag)|go:"GO:0042802"(identical protein binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|rcsb pdb:1EUV|rcsb pdb:1L2N|rcsb pdb:2EKE|rcsb pdb:3PGE|rcsb pdb:3QHT|rcsb pdb:3TIX|rcsb pdb:3UF8|rcsb pdb:3UQA|rcsb pdb:3UQB|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:3VAW|rcsb pdb:4FN2|rcsb pdb:4G50|rcsb pdb:4GGQ|rcsb pdb:4GIV|rcsb pdb:5D6J|rcsb pdb:5JNE|rcsb pdb:5KLX|rcsb pdb:5V8T|rcsb pdb:5YC2|rcsb pdb:5YCA|rcsb pdb:6CFP|rcsb pdb:6P81|rcsb pdb:6Q2S|rcsb pdb:6RPQ|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:6UKV|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6VEL|rcsb pdb:6VW2|rcsb pdb:7LTO|reactome:R-SCE-3065676|reactome:R-SCE-3065678|reactome:R-SCE-3065679|reactome:R-SCE-3108214|reactome:R-SCE-3108232|reactome:R-SCE-3232118|reactome:R-SCE-3899300|reactome:R-SCE-4085377|reactome:R-SCE-4551638|reactome:R-SCE-4570464|reactome:R-SCE-4615885|reactome:R-SCE-9615933|dip:DIP-1364N|mint:Q12306 - crc64:CE6FC4282E0E472C crc64:A2790DE7F315E1A7 figure legend:Supp. Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/11/15 2018/01/05 rogid:lKhHoZ+UA1ZcX8TOoZMgJX+fzI0559292 rogid:oFdVBxN9WlDXTM7oAnv+1vfcXFQ559292 rigid:FQfI+45VCeYUScAHFeJoDByW9FI false flag tag:?-? tag:?-?|binding-associated region:?-?|35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q12306 uniprotkb:Q12118 intact:EBI-17490|uniprotkb:D6VTD1|ensemblfungi:YDR510W intact:EBI-31784|uniprotkb:D6W273|ensemblfungi:YOR007C psi-mi:smt3_yeast(display_long)|uniprotkb:SMT3(gene name)|psi-mi:SMT3(display_short)|uniprotkb:D9719.15(orf name)|uniprotkb:YDR510W(locus name) psi-mi:sgt2_yeast(display_long)|uniprotkb:Viral protein U-binding protein(gene name synonym)|uniprotkb:SGT/UBP(gene name synonym)|uniprotkb:SGT2(gene name)|psi-mi:SGT2(display_short)|uniprotkb:UNF346(orf name)|uniprotkb:YOR007C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20850366|imex:IM-26462 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16718144|imex:IM-26462-37 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010798.1|sgd:S000002918|ensemblfungi:YDR510W(gene)|ensemblfungi:YDR510W_mRNA(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005940"(septin ring)|go:"GO:0016925"(protein sumoylation)|go:"GO:0031386"(protein tag)|go:"GO:0042802"(identical protein binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|rcsb pdb:1EUV|rcsb pdb:1L2N|rcsb pdb:2EKE|rcsb pdb:3PGE|rcsb pdb:3QHT|rcsb pdb:3TIX|rcsb pdb:3UF8|rcsb pdb:3UQA|rcsb pdb:3UQB|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:3VAW|rcsb pdb:4FN2|rcsb pdb:4G50|rcsb pdb:4GGQ|rcsb pdb:4GIV|rcsb pdb:5D6J|rcsb pdb:5JNE|rcsb pdb:5KLX|rcsb pdb:5V8T|rcsb pdb:5YC2|rcsb pdb:5YCA|rcsb pdb:6CFP|rcsb pdb:6P81|rcsb pdb:6Q2S|rcsb pdb:6RPQ|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:6UKV|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6VEL|rcsb pdb:6VW2|rcsb pdb:7LTO|reactome:R-SCE-3065676|reactome:R-SCE-3065678|reactome:R-SCE-3065679|reactome:R-SCE-3108214|reactome:R-SCE-3108232|reactome:R-SCE-3232118|reactome:R-SCE-3899300|reactome:R-SCE-4085377|reactome:R-SCE-4551638|reactome:R-SCE-4570464|reactome:R-SCE-4615885|reactome:R-SCE-9615933|dip:DIP-1364N|mint:Q12306 refseq:NP_014649.1|sgd:S000005533|dip:DIP-1983N|mint:Q12118|ensemblfungi:YOR007C(gene)|ensemblfungi:YOR007C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072380"(TRC complex)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|rcsb pdb:2LXB|rcsb pdb:2LXC|rcsb pdb:3ZDM|rcsb pdb:4ASV|rcsb pdb:4ASW|rcsb pdb:5LYN|rcsb pdb:5LYP|reactome:R-SCE-9609523 - crc64:A2790DE7F315E1A7 crc64:33539B74F742BD3C figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2017/11/15 2018/07/12 rogid:oFdVBxN9WlDXTM7oAnv+1vfcXFQ559292 rogid:u4qztYWJIAVQOzZGnkLFnO3S2NA559292 rigid:uchlV9WxWA69j/xkpfgLfHNw/DE false tag:?-?|binding-associated region:?-? his tag:?-?|sufficient binding region:58-346|necessary binding region:208-346 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)