#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P22216	uniprotkb:P53135	intact:EBI-17843|uniprotkb:D6W3L5|uniprotkb:Q6B1S1|ensemblfungi:YPL153C	intact:EBI-23925|uniprotkb:D6VU34|ensemblfungi:YGL113W	psi-mi:rad53_yeast(display_long)|uniprotkb:RAD53(gene name)|psi-mi:RAD53(display_short)|uniprotkb:MEC2(gene name synonym)|uniprotkb:SAD1(gene name synonym)|uniprotkb:Serine-protein kinase 1(gene name synonym)|uniprotkb:SPK1(gene name synonym)|uniprotkb:P2588(orf name)|uniprotkb:YPL153C(locus name)|uniprotkb:CHEK2 homolog(gene name synonym)	psi-mi:sld3_yeast(display_long)|uniprotkb:SLD3(gene name)|psi-mi:SLD3(display_short)|uniprotkb:G2980(orf name)|uniprotkb:YGL113W(locus name)	psi-mi:"MI:0424"(protein kinase assay)	Zegerman et al. (2010)	pubmed:20835227|doi:10.1038/nature09373|imex:IM-16284	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15877420|imex:IM-16284-1|dip:DIP-187421E	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015172.1|sgd:S000006074|ensemblfungi:YPL153C(gene)|ensemblfungi:YPL153C_mRNA(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008104"(protein localization)|go:"GO:0009202"(deoxyribonucleoside triphosphate biosynthetic process)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901857"(positive regulation of cellular respiration)|interpro:IPR000253(Forkhead-associated)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016256(Serine/threonine-protein kinase RAD53)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:1DMZ|rcsb pdb:1FHQ|rcsb pdb:1FHR|rcsb pdb:1G3G|rcsb pdb:1G6G|rcsb pdb:1J4K|rcsb pdb:1J4L|rcsb pdb:1J4O|rcsb pdb:1J4P|rcsb pdb:1J4Q|rcsb pdb:1K2M|rcsb pdb:1K2N|rcsb pdb:1K3J|rcsb pdb:1K3N|rcsb pdb:1K3Q|rcsb pdb:1QU5|rcsb pdb:2A0T|rcsb pdb:2JQI|rcsb pdb:2JQL|rcsb pdb:2YGV|rcsb pdb:4PDP|rcsb pdb:4PDS|rcsb pdb:5T2F|rcsb pdb:5T2S|rcsb pdb:5XZV|rcsb pdb:5XZW|rcsb pdb:6C4U|dip:DIP-2322N|mint:P22216	sgd:S000003081|refseq:NP_011402.3|dip:DIP-5481N|mint:P53135|ensemblfungi:YGL113W(gene)|ensemblfungi:YGL113W_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007049"(cell cycle)|go:"GO:0031261"(DNA replication preinitiation complex)|interpro:IPR013948(DNA replication regulator Sld3)|interpro:IPR041393|interpro:IPR042511|rcsb pdb:3WI3	psi-mi:"MI:0465"(dip)	crc64:84A9612229CA72D1	crc64:6E59D0DB3C082C28	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:OU8gjvSvTtvDvk+en1y8hyEjFhI559292	rogid:1uxenWX3lYYMDUWr0mAE207XsHI559292	rigid:5d/RfRrOWgcFmqa877di/LVK63E	false	-	sufficient binding region:400-529|sufficient binding region:530-668|O-phospho-L-serine:569-569	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q08032	uniprotkb:P53135	intact:EBI-4292|uniprotkb:Q05908|uniprotkb:D6VYA3|ensemblfungi:YLR103C	intact:EBI-23925|uniprotkb:D6VU34|ensemblfungi:YGL113W	psi-mi:cdc45_yeast(display_long)|uniprotkb:CDC45(gene name)|psi-mi:CDC45(display_short)|uniprotkb:YLR103C(locus name)|uniprotkb:L8004.11(orf name)|uniprotkb:SLD4(gene name synonym)	psi-mi:sld3_yeast(display_long)|uniprotkb:SLD3(gene name)|psi-mi:SLD3(display_short)|uniprotkb:G2980(orf name)|uniprotkb:YGL113W(locus name)	psi-mi:"MI:0018"(two hybrid)	Zegerman et al. (2010)	pubmed:20835227|doi:10.1038/nature09373|imex:IM-16284	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15877460|imex:IM-16284-3|dip:DIP-187424E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013204.1|sgd:S000004093|dip:DIP-2405N|mint:Q08032|ensemblfungi:YLR103C(gene)|ensemblfungi:YLR103C_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0071162"(CMG complex)|go:"GO:1902977"(mitotic DNA replication preinitiation complex assembly)|interpro:IPR003874(CDC45-like protein)|rcsb pdb:3JC5|rcsb pdb:3JC6|rcsb pdb:3JC7|rcsb pdb:5U8S|rcsb pdb:5U8T|rcsb pdb:6HV9|rcsb pdb:6PTJ|rcsb pdb:6PTN|rcsb pdb:6PTO|rcsb pdb:6SKL|rcsb pdb:6U0M|reactome:R-SCE-68962	sgd:S000003081|refseq:NP_011402.3|dip:DIP-5481N|mint:P53135|ensemblfungi:YGL113W(gene)|ensemblfungi:YGL113W_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007049"(cell cycle)|go:"GO:0031261"(DNA replication preinitiation complex)|interpro:IPR013948(DNA replication regulator Sld3)|interpro:IPR041393|interpro:IPR042511|rcsb pdb:3WI3	psi-mi:"MI:0465"(dip)	crc64:6500DDD62EC4E8EE	crc64:6E59D0DB3C082C28	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/06	2017/08/10	rogid:ErMEWxRKsJsPBDo5EfTfBL57hAY559292	rogid:1uxenWX3lYYMDUWr0mAE207XsHI559292	rigid:uw4fgpDwG3RC5ozWdAdZjE0hM8g	false	-	mutation disrupting interaction:310-310,306-306	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P47027	uniprotkb:P53135	intact:EBI-25984|uniprotkb:Q05712|uniprotkb:D6VW94|ensemblfungi:YJL090C	intact:EBI-23925|uniprotkb:D6VU34|ensemblfungi:YGL113W	psi-mi:dpb11_yeast(display_long)|uniprotkb:DPB11(gene name)|psi-mi:DPB11(display_short)|uniprotkb:J0918(orf name)|uniprotkb:YJL090C(locus name)	psi-mi:sld3_yeast(display_long)|uniprotkb:SLD3(gene name)|psi-mi:SLD3(display_short)|uniprotkb:G2980(orf name)|uniprotkb:YGL113W(locus name)	psi-mi:"MI:0018"(two hybrid)	Zegerman et al. (2010)	pubmed:20835227|doi:10.1038/nature09373|imex:IM-16284	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15877481|imex:IM-16284-4|dip:DIP-187422E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003626|refseq:NP_012445.1|dip:DIP-5037N|ensemblfungi:YJL090C(gene)|ensemblfungi:YJL090C_mRNA(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000725"(recombinational repair)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007533"(mating type switching)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1902597"(positive regulation of DNA replication origin binding)|interpro:IPR001357(BRCT)|interpro:IPR036420	sgd:S000003081|refseq:NP_011402.3|dip:DIP-5481N|mint:P53135|ensemblfungi:YGL113W(gene)|ensemblfungi:YGL113W_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007049"(cell cycle)|go:"GO:0031261"(DNA replication preinitiation complex)|interpro:IPR013948(DNA replication regulator Sld3)|interpro:IPR041393|interpro:IPR042511|rcsb pdb:3WI3	psi-mi:"MI:0465"(dip)	crc64:79B3A9BC7815E440	crc64:6E59D0DB3C082C28	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/06	2017/08/10	rogid:CYn2Q78DOL/+HPutAsKRuKofolE559292	rogid:1uxenWX3lYYMDUWr0mAE207XsHI559292	rigid:qAs64ZNbIttjeGQqTIH4VT+iG9E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12488	uniprotkb:P53135	intact:EBI-22066|uniprotkb:D6VRZ9|ensemblfungi:YDR013W	intact:EBI-23925|uniprotkb:D6VU34|ensemblfungi:YGL113W	psi-mi:psf1_yeast(display_long)|uniprotkb:Partner of Sld five 1(gene name synonym)|uniprotkb:YDR013W(locus name)|uniprotkb:YD8119.18(orf name)|uniprotkb:PZA208(orf name)|uniprotkb:PSF1(gene name)|psi-mi:PSF1(display_short)	psi-mi:sld3_yeast(display_long)|uniprotkb:SLD3(gene name)|psi-mi:SLD3(display_short)|uniprotkb:G2980(orf name)|uniprotkb:YGL113W(locus name)	psi-mi:"MI:0018"(two hybrid)	Zegerman et al. (2010)	pubmed:20835227|doi:10.1038/nature09373|imex:IM-16284	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15877443|imex:IM-16284-2|dip:DIP-187423E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002420|refseq:NP_010296.3|dip:DIP-1812N|go:"GO:0071162"(CMG complex)|go:"GO:1902983"(DNA strand elongation involved in mitotic DNA replication)|interpro:IPR005339(GINS complex, Psf1 component)|interpro:IPR021151|interpro:IPR036224|rcsb pdb:3JC5|rcsb pdb:3JC6|rcsb pdb:3JC7|rcsb pdb:5U8S|rcsb pdb:5U8T|rcsb pdb:6HV9|rcsb pdb:6PTJ|rcsb pdb:6PTN|rcsb pdb:6PTO|rcsb pdb:6SKL|rcsb pdb:6U0M|reactome:R-SCE-176974|ensemblfungi:YDR013W(gene)|ensemblfungi:YDR013W_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000811"(GINS complex)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031298"(replication fork protection complex)|mint:Q12488	sgd:S000003081|refseq:NP_011402.3|dip:DIP-5481N|mint:P53135|ensemblfungi:YGL113W(gene)|ensemblfungi:YGL113W_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007049"(cell cycle)|go:"GO:0031261"(DNA replication preinitiation complex)|interpro:IPR013948(DNA replication regulator Sld3)|interpro:IPR041393|interpro:IPR042511|rcsb pdb:3WI3	psi-mi:"MI:0465"(dip)	crc64:4667D8152C1AB5B4	crc64:6E59D0DB3C082C28	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/06	2017/08/10	rogid:gFGPyjIrRFLZEYnz/ugV//hl2zs559292	rogid:1uxenWX3lYYMDUWr0mAE207XsHI559292	rigid:HXN1LjemQVyky/ImAjkkyhf2t60	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P47027	uniprotkb:P53135	intact:EBI-25984|uniprotkb:Q05712|uniprotkb:D6VW94|ensemblfungi:YJL090C	intact:EBI-23925|uniprotkb:D6VU34|ensemblfungi:YGL113W	psi-mi:dpb11_yeast(display_long)|uniprotkb:DPB11(gene name)|psi-mi:DPB11(display_short)|uniprotkb:J0918(orf name)|uniprotkb:YJL090C(locus name)	psi-mi:sld3_yeast(display_long)|uniprotkb:SLD3(gene name)|psi-mi:SLD3(display_short)|uniprotkb:G2980(orf name)|uniprotkb:YGL113W(locus name)	psi-mi:"MI:0096"(pull down)	Zegerman et al. (2010)	pubmed:20835227|doi:10.1038/nature09373|imex:IM-16284	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15877498|imex:IM-16284-5|dip:DIP-187422E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003626|refseq:NP_012445.1|dip:DIP-5037N|ensemblfungi:YJL090C(gene)|ensemblfungi:YJL090C_mRNA(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000725"(recombinational repair)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007533"(mating type switching)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1902597"(positive regulation of DNA replication origin binding)|interpro:IPR001357(BRCT)|interpro:IPR036420	sgd:S000003081|refseq:NP_011402.3|dip:DIP-5481N|mint:P53135|ensemblfungi:YGL113W(gene)|ensemblfungi:YGL113W_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007049"(cell cycle)|go:"GO:0031261"(DNA replication preinitiation complex)|interpro:IPR013948(DNA replication regulator Sld3)|interpro:IPR041393|interpro:IPR042511|rcsb pdb:3WI3	psi-mi:"MI:0465"(dip)	crc64:79B3A9BC7815E440	crc64:6E59D0DB3C082C28	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:CYn2Q78DOL/+HPutAsKRuKofolE559292	rogid:1uxenWX3lYYMDUWr0mAE207XsHI559292	rigid:qAs64ZNbIttjeGQqTIH4VT+iG9E	false	glutathione s tranferase tag:c-c	sufficient binding region:530-668|32p radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)