#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P32829	uniprotkb:P12753	intact:EBI-11255|uniprotkb:P87289|uniprotkb:Q07173|uniprotkb:D6W049|ensemblfungi:YMR224C	intact:EBI-14700|uniprotkb:D6W0U3|ensemblfungi:YNL250W	psi-mi:mre11_yeast(display_long)|uniprotkb:YM9959.06C(orf name)|uniprotkb:YMR224C(locus name)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)	psi-mi:rad50_yeast(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short)|uniprotkb:YNL250W(locus name)|uniprotkb:N0872(orf name)|uniprotkb:153 kDa protein(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Niu et al. (2010)	pubmed:20811460|doi:10.1038/nature09318|imex:IM-16289	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15875418|imex:IM-16289-1|dip:DIP-143338E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0010780"(meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030437"(ascospore formation)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046940"(nucleoside monophosphate phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0051037"(regulation of transcription involved in meiotic cell cycle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|reactome:R-SCE-1834949|reactome:R-SCE-5693548|go:"GO:0051880"(G-quadruplex DNA binding)|ensemblfungi:YMR224C(gene)|ensemblfungi:YMR224C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_013951.1|sgd:S000004837|mint:P32829|dip:DIP-1313N	refseq:NP_014149.1|sgd:S000005194|ensemblfungi:YNL250W(gene)|ensemblfungi:YNL250W_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0032078"(negative regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR004584(Recombination/repair protein Rad50)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|reactome:R-SCE-5693548|go:"GO:0007129"(homologous chromosome pairing at meiosis)|dip:DIP-2419N|mint:P12753	psi-mi:"MI:0465"(dip)	crc64:D58433E32E852B73	crc64:58A0AA173AC5677E	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:q3Y06P4MqnJ1vjF7TFYmEzYB9zI559292	rogid:5Fc4FL8mWNa6ZVO7CVaEwv5ccuk559292	rigid:yZf89qyO97mr7yLmN2GqNxx5Xm4	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P32829	uniprotkb:P33301	intact:EBI-11255|uniprotkb:P87289|uniprotkb:Q07173|uniprotkb:D6W049|ensemblfungi:YMR224C	intact:EBI-20599|uniprotkb:D6VT00|ensemblfungi:YDR369C	psi-mi:mre11_yeast(display_long)|uniprotkb:YM9959.06C(orf name)|uniprotkb:YMR224C(locus name)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)	psi-mi:xrs2_yeast(display_long)|uniprotkb:XRS2(gene name)|psi-mi:XRS2(display_short)|uniprotkb:D9481.13(orf name)|uniprotkb:YDR369C(locus name)	psi-mi:"MI:0071"(molecular sieving)	Niu et al. (2010)	pubmed:20811460|doi:10.1038/nature09318|imex:IM-16289	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15875418|imex:IM-16289-1|dip:DIP-143338E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0010780"(meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030437"(ascospore formation)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046940"(nucleoside monophosphate phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0051037"(regulation of transcription involved in meiotic cell cycle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|reactome:R-SCE-1834949|reactome:R-SCE-5693548|go:"GO:0051880"(G-quadruplex DNA binding)|ensemblfungi:YMR224C(gene)|ensemblfungi:YMR224C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_013951.1|sgd:S000004837|mint:P32829|dip:DIP-1313N	sgd:S000002777|refseq:NP_010657.3|ensemblfungi:YDR369C(gene)|ensemblfungi:YDR369C_mRNA(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|dip:DIP-2420N|mint:P33301	psi-mi:"MI:0465"(dip)	crc64:D58433E32E852B73	crc64:833DAD6D20F6693E	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:q3Y06P4MqnJ1vjF7TFYmEzYB9zI559292	rogid:o505mxGL67ZY1mBUls7e15A4JTY559292	rigid:yZf89qyO97mr7yLmN2GqNxx5Xm4	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P27694	uniprotkb:P15927	intact:EBI-621389|ensembl:ENSP00000254719|uniprotkb:Q59ES9|uniprotkb:A8K0Y9	intact:EBI-621404|ensembl:ENSP00000363021|uniprotkb:Q52II0|uniprotkb:Q5TEI9|uniprotkb:Q5TEJ5	psi-mi:rfa1_human(display_long)|uniprotkb:Replication factor A protein 1(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein(gene name synonym)|uniprotkb:RPA1(gene name)|psi-mi:RPA1(display_short)|uniprotkb:REPA1(gene name synonym)|uniprotkb:RPA70(gene name synonym)	psi-mi:rfa2_human(display_long)|uniprotkb:RPA34(gene name synonym)|uniprotkb:Replication protein A 34 kDa subunit(gene name synonym)|uniprotkb:Replication factor A protein 2(gene name synonym)|uniprotkb:RPA2(gene name)|psi-mi:RPA2(display_short)|uniprotkb:REPA2(gene name synonym)|uniprotkb:RPA32(gene name synonym)	psi-mi:"MI:0096"(pull down)	Niu et al. (2010)	pubmed:20811460|doi:10.1038/nature09318|imex:IM-16289	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15875436|imex:IM-16289-2|dip:DIP-40050E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132383(gene)|ensembl:ENST00000254719(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016605"(PML body)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0090734"(site of DNA damage)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004591(Replication factor-a protein 1 Rpa1)|interpro:IPR007199(Replication factor-A protein 1, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR013955(Replication factor-A, C-terminal)|interpro:IPR031657|go:"GO:0006268"(DNA unwinding involved in DNA replication)|mint:P27694|rcsb pdb:1EWI|rcsb pdb:1FGU|rcsb pdb:1JMC|rcsb pdb:1L1O|rcsb pdb:2B29|rcsb pdb:2B3G|rcsb pdb:4IJH|rcsb pdb:4IJL|rcsb pdb:4IPC|rcsb pdb:4IPD|rcsb pdb:4IPG|rcsb pdb:4IPH|rcsb pdb:4LUO|rcsb pdb:4LUV|rcsb pdb:4LUZ|rcsb pdb:4LW1|rcsb pdb:4LWC|rcsb pdb:4NB3|rcsb pdb:4O0A|rcsb pdb:4R4C|rcsb pdb:4R4I|rcsb pdb:4R4O|rcsb pdb:4R4Q|rcsb pdb:4R4T|rcsb pdb:5E7N|rcsb pdb:5EAY|rcsb pdb:5N85|rcsb pdb:5N8A|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|reactome:R-HSA-3108214|refseq:NP_002936.1|dip:DIP-24189N	rcsb pdb:1L1O|rcsb pdb:1QUQ|rcsb pdb:1Z1D|rcsb pdb:2PI2|rcsb pdb:2PQA|rcsb pdb:2Z6K|rcsb pdb:3KDF|rcsb pdb:4MQV|rcsb pdb:4OU0|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|rcsb pdb:1DPU|ensembl:ENSG00000117748(gene)|ensembl:ENST00000373912(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014646(Replication protein A, subunit RPA32)|interpro:IPR014892(Replication protein A C terminal)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|mint:P15927|refseq:NP_001273005.1|refseq:NP_002937.1|refseq:NP_001284487.1|dip:DIP-24187N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/06	2017/08/10	rogid:DRZpMUlGyS0Qa5XFEtx71k0iPig9606	rogid:+Ute8Lq5hnN0sLAQNWZb0cAbcTI9606	rigid:YCsG6kjuQHfchEm3q3eZH+xVGkU	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P27694	uniprotkb:P35244	intact:EBI-621389|ensembl:ENSP00000254719|uniprotkb:Q59ES9|uniprotkb:A8K0Y9	intact:EBI-621428|ensembl:ENSP00000223129|ensembl:ENSP00000379914|uniprotkb:Q549U6|intact:EBI-1058317	psi-mi:rfa1_human(display_long)|uniprotkb:Replication factor A protein 1(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein(gene name synonym)|uniprotkb:RPA1(gene name)|psi-mi:RPA1(display_short)|uniprotkb:REPA1(gene name synonym)|uniprotkb:RPA70(gene name synonym)	psi-mi:rfa3_human(display_long)|uniprotkb:Replication factor A protein 3(gene name synonym)|uniprotkb:RPA3(gene name)|psi-mi:RPA3(display_short)|uniprotkb:REPA3(gene name synonym)|uniprotkb:RPA14(gene name synonym)	psi-mi:"MI:0096"(pull down)	Niu et al. (2010)	pubmed:20811460|doi:10.1038/nature09318|imex:IM-16289	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15875436|imex:IM-16289-2|dip:DIP-40050E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132383(gene)|ensembl:ENST00000254719(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016605"(PML body)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0090734"(site of DNA damage)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004591(Replication factor-a protein 1 Rpa1)|interpro:IPR007199(Replication factor-A protein 1, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR013955(Replication factor-A, C-terminal)|interpro:IPR031657|go:"GO:0006268"(DNA unwinding involved in DNA replication)|mint:P27694|rcsb pdb:1EWI|rcsb pdb:1FGU|rcsb pdb:1JMC|rcsb pdb:1L1O|rcsb pdb:2B29|rcsb pdb:2B3G|rcsb pdb:4IJH|rcsb pdb:4IJL|rcsb pdb:4IPC|rcsb pdb:4IPD|rcsb pdb:4IPG|rcsb pdb:4IPH|rcsb pdb:4LUO|rcsb pdb:4LUV|rcsb pdb:4LUZ|rcsb pdb:4LW1|rcsb pdb:4LWC|rcsb pdb:4NB3|rcsb pdb:4O0A|rcsb pdb:4R4C|rcsb pdb:4R4I|rcsb pdb:4R4O|rcsb pdb:4R4Q|rcsb pdb:4R4T|rcsb pdb:5E7N|rcsb pdb:5EAY|rcsb pdb:5N85|rcsb pdb:5N8A|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|reactome:R-HSA-3108214|refseq:NP_002936.1|dip:DIP-24189N	go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0035861"(site of double-strand break)|ensembl:ENSG00000106399(gene)|go:"GO:0042127"(regulation of cell population proliferation)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR013970(Replication factor A protein 3)|mint:P35244|rcsb pdb:1L1O|rcsb pdb:1QUQ|rcsb pdb:2PI2|rcsb pdb:2PQA|rcsb pdb:2Z6K|rcsb pdb:3KDF|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|ensembl:ENST00000223129(transcript)|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|ensembl:ENST00000396682(transcript)|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|refseq:NP_002938.1|dip:DIP-24190N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/06	2017/08/10	rogid:DRZpMUlGyS0Qa5XFEtx71k0iPig9606	rogid:hHO7MxGGHUjz30HXSBZd9cXOq6I9606	rigid:YCsG6kjuQHfchEm3q3eZH+xVGkU	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P38859	uniprotkb:P22336	intact:EBI-5973|uniprotkb:D3DLB3|ensemblfungi:YHR164C	intact:EBI-14971|uniprotkb:P38906|uniprotkb:D6VPL9|ensemblfungi:YAR007C	psi-mi:dna2_yeast(display_long)|uniprotkb:YHR164C(locus name)|uniprotkb:DNA2(gene name)|psi-mi:DNA2(display_short)	psi-mi:rfa1_yeast(display_long)|uniprotkb:RFA1(gene name)|psi-mi:RFA1(display_short)|uniprotkb:BUF2(gene name synonym)|uniprotkb:YAR007C(locus name)|uniprotkb:FUN3(orf name)|uniprotkb:Replication protein A 69 kDa DNA-binding subunit(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein(gene name synonym)|uniprotkb:DNA-binding protein BUF2(gene name synonym)|uniprotkb:RPA1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Niu et al. (2010)	pubmed:20811460|doi:10.1038/nature09318|imex:IM-16289	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15875454|imex:IM-16289-3|dip:DIP-15073E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012034.1|sgd:S000001207|dip:DIP-2324N|mint:P38859|ensemblfungi:YHR164C(gene)|ensemblfungi:YHR164C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0017116"(single-stranded DNA helicase activity)|go:"GO:0033567"(DNA replication, Okazaki fragment processing)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR014808(DNA replication factor Dna2)|interpro:IPR026851|interpro:IPR027417|interpro:IPR041677|interpro:IPR041679|rcsb pdb:5HOG|reactome:R-SCE-69166	refseq:NP_009404.1|sgd:S000000065|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-5696397|reactome:R-SCE-6782135|reactome:R-SCE-6782210|reactome:R-SCE-68962|reactome:R-SCE-69166|reactome:R-SCE-5655862|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensemblfungi:YAR007C(gene)|ensemblfungi:YAR007C_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0006260"(DNA replication)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006312"(mitotic recombination)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030491"(heteroduplex formation)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043934"(sporulation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004591(Replication factor-a protein 1 Rpa1)|interpro:IPR007199(Replication factor-A protein 1, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR013955(Replication factor-A, C-terminal)|interpro:IPR031657|rcsb pdb:1YNX|rcsb pdb:5M1X|rcsb pdb:5OMB|rcsb pdb:5OMC|rcsb pdb:6I52|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-176187|dip:DIP-2512N|mint:P22336	psi-mi:"MI:0465"(dip)	crc64:213A0458A6C69D78	crc64:7EB8DFA6910EF8A8	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:+VyRMkGklCNbTB4ccazNeT9XiK4559292	rogid:g7zFw4pOaeYLHSwBeKICZVqA13I559292	rigid:t/J7S18DS+bsq97Asr/GbsdgX50	false	sufficient binding region:1-405|his tag:c-c	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P35187	uniprotkb:P32829	intact:EBI-17059|uniprotkb:D6W014|ensemblfungi:YMR190C	intact:EBI-11255|uniprotkb:P87289|uniprotkb:Q07173|uniprotkb:D6W049|ensemblfungi:YMR224C	psi-mi:sgs1_yeast(display_long)|uniprotkb:SGS1(gene name)|psi-mi:SGS1(display_short)|uniprotkb:TPS1(gene name synonym)|uniprotkb:YMR190C(locus name)|uniprotkb:YM9646.02C(orf name)|uniprotkb:Helicase TPS1(gene name synonym)	psi-mi:mre11_yeast(display_long)|uniprotkb:YM9959.06C(orf name)|uniprotkb:YMR224C(locus name)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)	psi-mi:"MI:0096"(pull down)	Niu et al. (2010)	pubmed:20811460|doi:10.1038/nature09318|imex:IM-16289	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15875475|imex:IM-16289-4|dip:DIP-187431E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010520"(regulation of reciprocal meiotic recombination)|go:"GO:0010947"(negative regulation of meiotic joint molecule formation)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051276"(chromosome organization)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0005634"(nucleus)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR022758|interpro:IPR027417|interpro:IPR032284|interpro:IPR036388|rcsb pdb:1D8B|interpro:IPR001650(DNA/RNA helicase, C-terminal)|refseq:NP_013915.1|sgd:S000004802|ensemblfungi:YMR190C(gene)|ensemblfungi:YMR190C_mRNA(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|dip:DIP-2911N|mint:P35187	go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0010780"(meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030437"(ascospore formation)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046940"(nucleoside monophosphate phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0051037"(regulation of transcription involved in meiotic cell cycle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|reactome:R-SCE-1834949|reactome:R-SCE-5693548|go:"GO:0051880"(G-quadruplex DNA binding)|ensemblfungi:YMR224C(gene)|ensemblfungi:YMR224C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_013951.1|sgd:S000004837|mint:P32829|dip:DIP-1313N	psi-mi:"MI:0465"(dip)	crc64:0DC320B41756A3C3	crc64:D58433E32E852B73	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:kSX/9U/Qjnhm6doWBmFCKOC8dJo559292	rogid:q3Y06P4MqnJ1vjF7TFYmEzYB9zI559292	rigid:FwO3PYnsKY9ZP1K3NUFIKVqxzcQ	false	his tag:n-n|flag tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P13099	uniprotkb:P35187	intact:EBI-19365|uniprotkb:D6VYN4|ensemblfungi:YLR234W	intact:EBI-17059|uniprotkb:D6W014|ensemblfungi:YMR190C	psi-mi:top3_yeast(display_long)|uniprotkb:TOP3(gene name)|psi-mi:TOP3(display_short)|uniprotkb:EDR1(gene name synonym)|uniprotkb:YLR234W(locus name)|uniprotkb:L8083.3(orf name)|uniprotkb:DNA topoisomerase III(gene name synonym)	psi-mi:sgs1_yeast(display_long)|uniprotkb:SGS1(gene name)|psi-mi:SGS1(display_short)|uniprotkb:TPS1(gene name synonym)|uniprotkb:YMR190C(locus name)|uniprotkb:YM9646.02C(orf name)|uniprotkb:Helicase TPS1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Niu et al. (2010)	pubmed:20811460|doi:10.1038/nature09318|imex:IM-16289	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15875497|imex:IM-16289-5|dip:DIP-3932E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013335.1|sgd:S000004224|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|go:"GO:0003916"(DNA topoisomerase activity)|ensemblfungi:YLR234W(gene)|ensemblfungi:YLR234W_mRNA(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0003677"(DNA binding)|dip:DIP-2912N|mint:P13099	go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010520"(regulation of reciprocal meiotic recombination)|go:"GO:0010947"(negative regulation of meiotic joint molecule formation)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051276"(chromosome organization)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0005634"(nucleus)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR022758|interpro:IPR027417|interpro:IPR032284|interpro:IPR036388|rcsb pdb:1D8B|interpro:IPR001650(DNA/RNA helicase, C-terminal)|refseq:NP_013915.1|sgd:S000004802|ensemblfungi:YMR190C(gene)|ensemblfungi:YMR190C_mRNA(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|dip:DIP-2911N|mint:P35187	psi-mi:"MI:0465"(dip)	crc64:51DF78936A88B4F4	crc64:0DC320B41756A3C3	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:7guk14sg6ZTut5+2ip8U/NkS9M0559292	rogid:kSX/9U/Qjnhm6doWBmFCKOC8dJo559292	rigid:mfOklneip12bobp9ceQkMEPq+aw	false	his tag:c-c	his tag:n-n|flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q02685	uniprotkb:P13099	intact:EBI-38690|uniprotkb:D6W3Y8|ensemblfungi:YPL024W	intact:EBI-19365|uniprotkb:D6VYN4|ensemblfungi:YLR234W	psi-mi:rmi1_yeast(display_long)|uniprotkb:RMI1(gene name)|psi-mi:RMI1(display_short)|uniprotkb:NCE4(gene name synonym)|uniprotkb:YPL024W(locus name)	psi-mi:top3_yeast(display_long)|uniprotkb:TOP3(gene name)|psi-mi:TOP3(display_short)|uniprotkb:EDR1(gene name synonym)|uniprotkb:YLR234W(locus name)|uniprotkb:L8083.3(orf name)|uniprotkb:DNA topoisomerase III(gene name synonym)	psi-mi:"MI:0096"(pull down)	Niu et al. (2010)	pubmed:20811460|doi:10.1038/nature09318|imex:IM-16289	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15875521|imex:IM-16289-6|dip:DIP-187429E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015301.1|sgd:S000005945|mint:Q02685|dip:DIP-4039N|ensemblfungi:YPL024W(gene)|ensemblfungi:YPL024W_mRNA(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR013894(Region of unknown function DUF1767)	refseq:NP_013335.1|sgd:S000004224|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|go:"GO:0003916"(DNA topoisomerase activity)|ensemblfungi:YLR234W(gene)|ensemblfungi:YLR234W_mRNA(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0003677"(DNA binding)|dip:DIP-2912N|mint:P13099	psi-mi:"MI:0465"(dip)	crc64:65EF152F50BF0084	crc64:51DF78936A88B4F4	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/06	2017/08/10	rogid:6vrkb5T1C2mV3fInk0bzsKuIudQ559292	rogid:7guk14sg6ZTut5+2ip8U/NkS9M0559292	rigid:AOqUNTYjZkSX8ZpDxfUXp0axqNM	false	-	his tag:c-c	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P32829	uniprotkb:P38859	intact:EBI-11255|uniprotkb:P87289|uniprotkb:Q07173|uniprotkb:D6W049|ensemblfungi:YMR224C	intact:EBI-5973|uniprotkb:D3DLB3|ensemblfungi:YHR164C	psi-mi:mre11_yeast(display_long)|uniprotkb:YM9959.06C(orf name)|uniprotkb:YMR224C(locus name)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)	psi-mi:dna2_yeast(display_long)|uniprotkb:YHR164C(locus name)|uniprotkb:DNA2(gene name)|psi-mi:DNA2(display_short)	psi-mi:"MI:0096"(pull down)	Niu et al. (2010)	pubmed:20811460|doi:10.1038/nature09318|imex:IM-16289	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15875558|imex:IM-16289-8|dip:DIP-187430E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0010780"(meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030437"(ascospore formation)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046940"(nucleoside monophosphate phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0051037"(regulation of transcription involved in meiotic cell cycle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|reactome:R-SCE-1834949|reactome:R-SCE-5693548|go:"GO:0051880"(G-quadruplex DNA binding)|ensemblfungi:YMR224C(gene)|ensemblfungi:YMR224C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_013951.1|sgd:S000004837|mint:P32829|dip:DIP-1313N	refseq:NP_012034.1|sgd:S000001207|dip:DIP-2324N|mint:P38859|ensemblfungi:YHR164C(gene)|ensemblfungi:YHR164C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0017116"(single-stranded DNA helicase activity)|go:"GO:0033567"(DNA replication, Okazaki fragment processing)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR014808(DNA replication factor Dna2)|interpro:IPR026851|interpro:IPR027417|interpro:IPR041677|interpro:IPR041679|rcsb pdb:5HOG|reactome:R-SCE-69166	psi-mi:"MI:0465"(dip)	crc64:D58433E32E852B73	crc64:213A0458A6C69D78	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:q3Y06P4MqnJ1vjF7TFYmEzYB9zI559292	rogid:+VyRMkGklCNbTB4ccazNeT9XiK4559292	rigid:U/WMWuGAM5Kt/1i5qf8ffxrViZA	false	-	his tag:c-c|flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P22336	uniprotkb:P26754	intact:EBI-14971|uniprotkb:P38906|uniprotkb:D6VPL9|ensemblfungi:YAR007C	intact:EBI-14976|uniprotkb:P38905|uniprotkb:D6W0N3|ensemblfungi:YNL312W	psi-mi:rfa1_yeast(display_long)|uniprotkb:RFA1(gene name)|psi-mi:RFA1(display_short)|uniprotkb:BUF2(gene name synonym)|uniprotkb:YAR007C(locus name)|uniprotkb:FUN3(orf name)|uniprotkb:Replication protein A 69 kDa DNA-binding subunit(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein(gene name synonym)|uniprotkb:DNA-binding protein BUF2(gene name synonym)|uniprotkb:RPA1(gene name synonym)	psi-mi:rfa2_yeast(display_long)|uniprotkb:RFA2(gene name)|psi-mi:RFA2(display_short)|uniprotkb:BUF1(gene name synonym)|uniprotkb:YNL312W(locus name)|uniprotkb:N0368(orf name)|uniprotkb:Replication protein A 36 kDa subunit(gene name synonym)|uniprotkb:DNA-binding protein BUF1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Niu et al. (2010)	pubmed:20811460|doi:10.1038/nature09318|imex:IM-16289	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15875540|imex:IM-16289-7|dip:DIP-18415E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009404.1|sgd:S000000065|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-5696397|reactome:R-SCE-6782135|reactome:R-SCE-6782210|reactome:R-SCE-68962|reactome:R-SCE-69166|reactome:R-SCE-5655862|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensemblfungi:YAR007C(gene)|ensemblfungi:YAR007C_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0006260"(DNA replication)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006312"(mitotic recombination)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030491"(heteroduplex formation)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043934"(sporulation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004591(Replication factor-a protein 1 Rpa1)|interpro:IPR007199(Replication factor-A protein 1, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR013955(Replication factor-A, C-terminal)|interpro:IPR031657|rcsb pdb:1YNX|rcsb pdb:5M1X|rcsb pdb:5OMB|rcsb pdb:5OMC|rcsb pdb:6I52|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-176187|dip:DIP-2512N|mint:P22336	refseq:NP_014087.1|sgd:S000005256|ensemblfungi:YNL312W(gene)|ensemblfungi:YNL312W_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR014646(Replication protein A, subunit RPA32)|interpro:IPR014892(Replication protein A C terminal)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|rcsb pdb:6I52|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-176187|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-5696397|reactome:R-SCE-6782135|reactome:R-SCE-6782210|reactome:R-SCE-68962|reactome:R-SCE-69166|interpro:IPR012340(Nucleic acid-binding, OB-fold)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006312"(mitotic recombination)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030491"(heteroduplex formation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045184"(establishment of protein localization)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|go:"GO:0000781"(chromosome, telomeric region)|dip:DIP-2518N|mint:P26754	psi-mi:"MI:0465"(dip)	crc64:7EB8DFA6910EF8A8	crc64:F6087501E4E28CC1	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/06	2017/08/10	rogid:g7zFw4pOaeYLHSwBeKICZVqA13I559292	rogid:CsitdDua0N9AQdlJn9I0RNmz3Ts559292	rigid:Lrg4m5Kt6vZS2HBi+20gIa3tSLI	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P22336	uniprotkb:P26755	intact:EBI-14971|uniprotkb:P38906|uniprotkb:D6VPL9|ensemblfungi:YAR007C	intact:EBI-14981|uniprotkb:D6VW15|ensemblfungi:YJL173C	psi-mi:rfa1_yeast(display_long)|uniprotkb:RFA1(gene name)|psi-mi:RFA1(display_short)|uniprotkb:BUF2(gene name synonym)|uniprotkb:YAR007C(locus name)|uniprotkb:FUN3(orf name)|uniprotkb:Replication protein A 69 kDa DNA-binding subunit(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein(gene name synonym)|uniprotkb:DNA-binding protein BUF2(gene name synonym)|uniprotkb:RPA1(gene name synonym)	psi-mi:rfa3_yeast(display_long)|uniprotkb:RFA3(gene name)|psi-mi:RFA3(display_short)|uniprotkb:YJL173C(locus name)|uniprotkb:J0506(orf name)|uniprotkb:Replication protein A 13 kDa subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Niu et al. (2010)	pubmed:20811460|doi:10.1038/nature09318|imex:IM-16289	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15875540|imex:IM-16289-7|dip:DIP-18415E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009404.1|sgd:S000000065|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-5696397|reactome:R-SCE-6782135|reactome:R-SCE-6782210|reactome:R-SCE-68962|reactome:R-SCE-69166|reactome:R-SCE-5655862|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensemblfungi:YAR007C(gene)|ensemblfungi:YAR007C_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0006260"(DNA replication)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006312"(mitotic recombination)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030491"(heteroduplex formation)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043934"(sporulation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004591(Replication factor-a protein 1 Rpa1)|interpro:IPR007199(Replication factor-A protein 1, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR013955(Replication factor-A, C-terminal)|interpro:IPR031657|rcsb pdb:1YNX|rcsb pdb:5M1X|rcsb pdb:5OMB|rcsb pdb:5OMC|rcsb pdb:6I52|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-176187|dip:DIP-2512N|mint:P22336	refseq:NP_012362.1|sgd:S000003709|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006312"(mitotic recombination)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030491"(heteroduplex formation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045184"(establishment of protein localization)|interpro:IPR013970(Replication factor A protein 3)|interpro:IPR016588(Replication factor A, subunit 3, Saccharomycetes)|rcsb pdb:6I52|go:"GO:0003690"(double-stranded DNA binding)|ensemblfungi:YJL173C(gene)|ensemblfungi:YJL173C_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000794"(condensed nuclear chromosome)|dip:DIP-2109N|mint:P26755	psi-mi:"MI:0465"(dip)	crc64:7EB8DFA6910EF8A8	crc64:5EC5D6FB56BAC008	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/06	2017/08/10	rogid:g7zFw4pOaeYLHSwBeKICZVqA13I559292	rogid:MEkK33m0QKH1Nn9NId9DfYZz4Oc559292	rigid:Lrg4m5Kt6vZS2HBi+20gIa3tSLI	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P13099	uniprotkb:P38859	intact:EBI-19365|uniprotkb:D6VYN4|ensemblfungi:YLR234W	intact:EBI-5973|uniprotkb:D3DLB3|ensemblfungi:YHR164C	psi-mi:top3_yeast(display_long)|uniprotkb:TOP3(gene name)|psi-mi:TOP3(display_short)|uniprotkb:EDR1(gene name synonym)|uniprotkb:YLR234W(locus name)|uniprotkb:L8083.3(orf name)|uniprotkb:DNA topoisomerase III(gene name synonym)	psi-mi:dna2_yeast(display_long)|uniprotkb:YHR164C(locus name)|uniprotkb:DNA2(gene name)|psi-mi:DNA2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Niu et al. (2010)	pubmed:20811460|doi:10.1038/nature09318|imex:IM-16289	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15875580|imex:IM-16289-9|dip:DIP-187432E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013335.1|sgd:S000004224|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|go:"GO:0003916"(DNA topoisomerase activity)|ensemblfungi:YLR234W(gene)|ensemblfungi:YLR234W_mRNA(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0003677"(DNA binding)|dip:DIP-2912N|mint:P13099	refseq:NP_012034.1|sgd:S000001207|dip:DIP-2324N|mint:P38859|ensemblfungi:YHR164C(gene)|ensemblfungi:YHR164C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0017116"(single-stranded DNA helicase activity)|go:"GO:0033567"(DNA replication, Okazaki fragment processing)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR014808(DNA replication factor Dna2)|interpro:IPR026851|interpro:IPR027417|interpro:IPR041677|interpro:IPR041679|rcsb pdb:5HOG|reactome:R-SCE-69166	psi-mi:"MI:0465"(dip)	crc64:51DF78936A88B4F4	crc64:213A0458A6C69D78	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:7guk14sg6ZTut5+2ip8U/NkS9M0559292	rogid:+VyRMkGklCNbTB4ccazNeT9XiK4559292	rigid:N435ANAKODbcp8mX8ApBwbmA4GM	false	his tag:c-c	his tag:c-c|flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)