#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P50281	uniprotkb:P21802-1	intact:EBI-992788|uniprotkb:Q6GSF3|uniprotkb:Q92678|uniprotkb:A8K5L0|ensembl:ENSP00000308208	intact:EBI-15489960|ensembl:ENSP00000351276	psi-mi:mmp14_human(display_long)|uniprotkb:Membrane-type matrix metalloproteinase 1(gene name synonym)|uniprotkb:Membrane-type-1 matrix metalloproteinase(gene name synonym)|uniprotkb:MMP-X1(gene name synonym)|uniprotkb:MMP14(gene name)|psi-mi:MMP14(display_short)	psi-mi:p21802-1(display_long)|uniprotkb:K-sam(gene name synonym)|uniprotkb:Keratinocyte growth factor receptor(gene name synonym)|uniprotkb:BEK(isoform synonym)|uniprotkb:FGFR2IIIc(isoform synonym)|uniprotkb:FGFR2(gene name)|psi-mi:FGFR2(display_short)|uniprotkb:BEK(gene name synonym)|uniprotkb:KGFR(gene name synonym)|uniprotkb:KSAM(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sugiyama et al. (2010)	pubmed:20798051|doi:10.1073/pnas.0914459107|imex:IM-17461	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15873344|imex:IM-17461-3|dip:DIP-188615E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000311852(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010831"(positive regulation of myotube differentiation)|ensembl:ENSG00000157227(gene)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016485"(protein processing)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031638"(zymogen activation)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0044354"(macropinosome)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048771"(tissue remodeling)|go:"GO:0048870"(cell motility)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060322"(head development)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0097094"(craniofacial suture morphogenesis)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990834"(response to odorant)|interpro:IPR000585(Hemopexin)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR021805|interpro:IPR024079|interpro:IPR033739|interpro:IPR036365|interpro:IPR036366|interpro:IPR036375|mint:P50281|rcsb pdb:1BQQ|rcsb pdb:1BUV|rcsb pdb:2MQS|rcsb pdb:3MA2|rcsb pdb:3X23|rcsb pdb:4P3C|rcsb pdb:4P3D|rcsb pdb:4QXU|rcsb pdb:5H0U|rcsb pdb:6CLZ|rcsb pdb:6CM1|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|rcsb pdb:3C7X|refseq:NP_004986.1|dip:DIP-35111N	ensembl:ENSG00000066468(gene)|ensembl:ENST00000358487(transcript)|intact:EBI-1028658(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/06	2017/08/10	rogid:x2H2pYgnfBvYy7Stikq3uk+ihhw9606	rogid:XW6x8AHgdb29IL3MhUFWpv4jaqE9606	rigid:Pg8uOS2KiJjw0UnpnZIV8TuoQpY	false	ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P50281	uniprotkb:P22455	intact:EBI-992788|uniprotkb:Q6GSF3|uniprotkb:Q92678|uniprotkb:A8K5L0|ensembl:ENSP00000308208	intact:EBI-6256193|uniprotkb:G3JVM2|uniprotkb:G3JVM5|uniprotkb:G3JVM7|uniprotkb:G3JVM9|uniprotkb:Q96KE5|ensembl:ENSP00000292408|ensembl:ENSP00000424960|uniprotkb:O43785|uniprotkb:Q14309|uniprotkb:Q71TW8|uniprotkb:Q8TDA0	psi-mi:mmp14_human(display_long)|uniprotkb:Membrane-type matrix metalloproteinase 1(gene name synonym)|uniprotkb:Membrane-type-1 matrix metalloproteinase(gene name synonym)|uniprotkb:MMP-X1(gene name synonym)|uniprotkb:MMP14(gene name)|psi-mi:MMP14(display_short)	psi-mi:fgfr4_human(display_long)|uniprotkb:FGFR4(gene name)|psi-mi:FGFR4(display_short)|uniprotkb:JTK2(gene name synonym)|uniprotkb:TKF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sugiyama et al. (2010)	pubmed:20798051|doi:10.1073/pnas.0914459107|imex:IM-17461	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15873323|imex:IM-17461-2|dip:DIP-188614E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000311852(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010831"(positive regulation of myotube differentiation)|ensembl:ENSG00000157227(gene)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016485"(protein processing)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031638"(zymogen activation)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0044354"(macropinosome)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048771"(tissue remodeling)|go:"GO:0048870"(cell motility)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060322"(head development)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0097094"(craniofacial suture morphogenesis)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990834"(response to odorant)|interpro:IPR000585(Hemopexin)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR021805|interpro:IPR024079|interpro:IPR033739|interpro:IPR036365|interpro:IPR036366|interpro:IPR036375|mint:P50281|rcsb pdb:1BQQ|rcsb pdb:1BUV|rcsb pdb:2MQS|rcsb pdb:3MA2|rcsb pdb:3X23|rcsb pdb:4P3C|rcsb pdb:4P3D|rcsb pdb:4QXU|rcsb pdb:5H0U|rcsb pdb:6CLZ|rcsb pdb:6CM1|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|rcsb pdb:3C7X|refseq:NP_004986.1|dip:DIP-35111N	refseq:NP_001278909.1|ensembl:ENSG00000160867(gene)|ensembl:ENST00000292408(transcript)|ensembl:ENST00000502906(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010715"(regulation of extracellular matrix disassembly)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030133"(transport vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|mint:P22455|rcsb pdb:1QCT|rcsb pdb:4QQ5|rcsb pdb:4QQC|rcsb pdb:4QQJ|rcsb pdb:4QQT|rcsb pdb:4QRC|rcsb pdb:4R6V|rcsb pdb:4TYE|rcsb pdb:4TYG|rcsb pdb:4TYI|rcsb pdb:4UXQ|rcsb pdb:4XCU|rcsb pdb:5JKG|rcsb pdb:5NUD|rcsb pdb:5NWZ|rcsb pdb:5XFF|rcsb pdb:5XFJ|rcsb pdb:6IUO|rcsb pdb:6IUP|rcsb pdb:6J6Y|rcsb pdb:6JPE|rcsb pdb:6JPJ|rcsb pdb:6NVG|rcsb pdb:6NVH|rcsb pdb:6NVI|rcsb pdb:6NVJ|rcsb pdb:6NVK|rcsb pdb:6V9C|rcsb pdb:6YI8|rcsb pdb:7DTZ|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1307965|reactome:R-HSA-1839128|reactome:R-HSA-190322|reactome:R-HSA-2219530|reactome:R-HSA-5654228|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654733|reactome:R-HSA-5655291|reactome:R-HSA-5673001|reactome:R-HSA-6811558|rcsb pdb:4TYJ|refseq:NP_002002.3|refseq:NP_075252.2|refseq:NP_998812.1|refseq:XP_005265895.1|dip:DIP-5149N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:x2H2pYgnfBvYy7Stikq3uk+ihhw9606	rogid:JQ3gV5Xg75wwE2tOvcKZ3Vr9Lgg9606	rigid:pga6LK8GBESzzYFdYu8Wo6Eakoc	false	ha tag:n-n	v5 tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P50281	uniprotkb:P22455	intact:EBI-992788|uniprotkb:Q6GSF3|uniprotkb:Q92678|uniprotkb:A8K5L0|ensembl:ENSP00000308208	intact:EBI-6256193|uniprotkb:G3JVM2|uniprotkb:G3JVM5|uniprotkb:G3JVM7|uniprotkb:G3JVM9|uniprotkb:Q96KE5|ensembl:ENSP00000292408|ensembl:ENSP00000424960|uniprotkb:O43785|uniprotkb:Q14309|uniprotkb:Q71TW8|uniprotkb:Q8TDA0	psi-mi:mmp14_human(display_long)|uniprotkb:Membrane-type matrix metalloproteinase 1(gene name synonym)|uniprotkb:Membrane-type-1 matrix metalloproteinase(gene name synonym)|uniprotkb:MMP-X1(gene name synonym)|uniprotkb:MMP14(gene name)|psi-mi:MMP14(display_short)	psi-mi:fgfr4_human(display_long)|uniprotkb:FGFR4(gene name)|psi-mi:FGFR4(display_short)|uniprotkb:JTK2(gene name synonym)|uniprotkb:TKF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sugiyama et al. (2010)	pubmed:20798051|doi:10.1073/pnas.0914459107|imex:IM-17461	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15873302|imex:IM-17461-1|dip:DIP-188614E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000311852(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010831"(positive regulation of myotube differentiation)|ensembl:ENSG00000157227(gene)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016485"(protein processing)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031638"(zymogen activation)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0044354"(macropinosome)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048771"(tissue remodeling)|go:"GO:0048870"(cell motility)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060322"(head development)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0097094"(craniofacial suture morphogenesis)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990834"(response to odorant)|interpro:IPR000585(Hemopexin)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR021805|interpro:IPR024079|interpro:IPR033739|interpro:IPR036365|interpro:IPR036366|interpro:IPR036375|mint:P50281|rcsb pdb:1BQQ|rcsb pdb:1BUV|rcsb pdb:2MQS|rcsb pdb:3MA2|rcsb pdb:3X23|rcsb pdb:4P3C|rcsb pdb:4P3D|rcsb pdb:4QXU|rcsb pdb:5H0U|rcsb pdb:6CLZ|rcsb pdb:6CM1|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|rcsb pdb:3C7X|refseq:NP_004986.1|dip:DIP-35111N	refseq:NP_001278909.1|ensembl:ENSG00000160867(gene)|ensembl:ENST00000292408(transcript)|ensembl:ENST00000502906(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010715"(regulation of extracellular matrix disassembly)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030133"(transport vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|mint:P22455|rcsb pdb:1QCT|rcsb pdb:4QQ5|rcsb pdb:4QQC|rcsb pdb:4QQJ|rcsb pdb:4QQT|rcsb pdb:4QRC|rcsb pdb:4R6V|rcsb pdb:4TYE|rcsb pdb:4TYG|rcsb pdb:4TYI|rcsb pdb:4UXQ|rcsb pdb:4XCU|rcsb pdb:5JKG|rcsb pdb:5NUD|rcsb pdb:5NWZ|rcsb pdb:5XFF|rcsb pdb:5XFJ|rcsb pdb:6IUO|rcsb pdb:6IUP|rcsb pdb:6J6Y|rcsb pdb:6JPE|rcsb pdb:6JPJ|rcsb pdb:6NVG|rcsb pdb:6NVH|rcsb pdb:6NVI|rcsb pdb:6NVJ|rcsb pdb:6NVK|rcsb pdb:6V9C|rcsb pdb:6YI8|rcsb pdb:7DTZ|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1307965|reactome:R-HSA-1839128|reactome:R-HSA-190322|reactome:R-HSA-2219530|reactome:R-HSA-5654228|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654733|reactome:R-HSA-5655291|reactome:R-HSA-5673001|reactome:R-HSA-6811558|rcsb pdb:4TYJ|refseq:NP_002002.3|refseq:NP_075252.2|refseq:NP_998812.1|refseq:XP_005265895.1|dip:DIP-5149N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/06	2017/08/10	rogid:x2H2pYgnfBvYy7Stikq3uk+ihhw9606	rogid:JQ3gV5Xg75wwE2tOvcKZ3Vr9Lgg9606	rigid:pga6LK8GBESzzYFdYu8Wo6Eakoc	false	ha tag:n-n	v5 tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P50281	uniprotkb:P22455	intact:EBI-992788|uniprotkb:Q6GSF3|uniprotkb:Q92678|uniprotkb:A8K5L0|ensembl:ENSP00000308208	intact:EBI-6256193|uniprotkb:G3JVM2|uniprotkb:G3JVM5|uniprotkb:G3JVM7|uniprotkb:G3JVM9|uniprotkb:Q96KE5|ensembl:ENSP00000292408|ensembl:ENSP00000424960|uniprotkb:O43785|uniprotkb:Q14309|uniprotkb:Q71TW8|uniprotkb:Q8TDA0	psi-mi:mmp14_human(display_long)|uniprotkb:Membrane-type matrix metalloproteinase 1(gene name synonym)|uniprotkb:Membrane-type-1 matrix metalloproteinase(gene name synonym)|uniprotkb:MMP-X1(gene name synonym)|uniprotkb:MMP14(gene name)|psi-mi:MMP14(display_short)	psi-mi:fgfr4_human(display_long)|uniprotkb:FGFR4(gene name)|psi-mi:FGFR4(display_short)|uniprotkb:JTK2(gene name synonym)|uniprotkb:TKF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sugiyama et al. (2010)	pubmed:20798051|doi:10.1073/pnas.0914459107|imex:IM-17461	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15873405|imex:IM-17461-6|dip:DIP-188614E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000311852(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010831"(positive regulation of myotube differentiation)|ensembl:ENSG00000157227(gene)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016485"(protein processing)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031638"(zymogen activation)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0044354"(macropinosome)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048771"(tissue remodeling)|go:"GO:0048870"(cell motility)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060322"(head development)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0097094"(craniofacial suture morphogenesis)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990834"(response to odorant)|interpro:IPR000585(Hemopexin)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR021805|interpro:IPR024079|interpro:IPR033739|interpro:IPR036365|interpro:IPR036366|interpro:IPR036375|mint:P50281|rcsb pdb:1BQQ|rcsb pdb:1BUV|rcsb pdb:2MQS|rcsb pdb:3MA2|rcsb pdb:3X23|rcsb pdb:4P3C|rcsb pdb:4P3D|rcsb pdb:4QXU|rcsb pdb:5H0U|rcsb pdb:6CLZ|rcsb pdb:6CM1|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|rcsb pdb:3C7X|refseq:NP_004986.1|dip:DIP-35111N	refseq:NP_001278909.1|ensembl:ENSG00000160867(gene)|ensembl:ENST00000292408(transcript)|ensembl:ENST00000502906(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010715"(regulation of extracellular matrix disassembly)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030133"(transport vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|mint:P22455|rcsb pdb:1QCT|rcsb pdb:4QQ5|rcsb pdb:4QQC|rcsb pdb:4QQJ|rcsb pdb:4QQT|rcsb pdb:4QRC|rcsb pdb:4R6V|rcsb pdb:4TYE|rcsb pdb:4TYG|rcsb pdb:4TYI|rcsb pdb:4UXQ|rcsb pdb:4XCU|rcsb pdb:5JKG|rcsb pdb:5NUD|rcsb pdb:5NWZ|rcsb pdb:5XFF|rcsb pdb:5XFJ|rcsb pdb:6IUO|rcsb pdb:6IUP|rcsb pdb:6J6Y|rcsb pdb:6JPE|rcsb pdb:6JPJ|rcsb pdb:6NVG|rcsb pdb:6NVH|rcsb pdb:6NVI|rcsb pdb:6NVJ|rcsb pdb:6NVK|rcsb pdb:6V9C|rcsb pdb:6YI8|rcsb pdb:7DTZ|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1307965|reactome:R-HSA-1839128|reactome:R-HSA-190322|reactome:R-HSA-2219530|reactome:R-HSA-5654228|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654733|reactome:R-HSA-5655291|reactome:R-HSA-5673001|reactome:R-HSA-6811558|rcsb pdb:4TYJ|refseq:NP_002002.3|refseq:NP_075252.2|refseq:NP_998812.1|refseq:XP_005265895.1|dip:DIP-5149N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:x2H2pYgnfBvYy7Stikq3uk+ihhw9606	rogid:JQ3gV5Xg75wwE2tOvcKZ3Vr9Lgg9606	rigid:pga6LK8GBESzzYFdYu8Wo6Eakoc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P50281	uniprotkb:P22455	intact:EBI-992788|uniprotkb:Q6GSF3|uniprotkb:Q92678|uniprotkb:A8K5L0|ensembl:ENSP00000308208	intact:EBI-6256193|uniprotkb:G3JVM2|uniprotkb:G3JVM5|uniprotkb:G3JVM7|uniprotkb:G3JVM9|uniprotkb:Q96KE5|ensembl:ENSP00000292408|ensembl:ENSP00000424960|uniprotkb:O43785|uniprotkb:Q14309|uniprotkb:Q71TW8|uniprotkb:Q8TDA0	psi-mi:mmp14_human(display_long)|uniprotkb:Membrane-type matrix metalloproteinase 1(gene name synonym)|uniprotkb:Membrane-type-1 matrix metalloproteinase(gene name synonym)|uniprotkb:MMP-X1(gene name synonym)|uniprotkb:MMP14(gene name)|psi-mi:MMP14(display_short)	psi-mi:fgfr4_human(display_long)|uniprotkb:FGFR4(gene name)|psi-mi:FGFR4(display_short)|uniprotkb:JTK2(gene name synonym)|uniprotkb:TKF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sugiyama et al. (2010)	pubmed:20798051|doi:10.1073/pnas.0914459107|imex:IM-17461	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15873384|imex:IM-17461-5|dip:DIP-188614E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000311852(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010831"(positive regulation of myotube differentiation)|ensembl:ENSG00000157227(gene)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016485"(protein processing)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031638"(zymogen activation)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0044354"(macropinosome)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048771"(tissue remodeling)|go:"GO:0048870"(cell motility)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060322"(head development)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0097094"(craniofacial suture morphogenesis)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990834"(response to odorant)|interpro:IPR000585(Hemopexin)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR021805|interpro:IPR024079|interpro:IPR033739|interpro:IPR036365|interpro:IPR036366|interpro:IPR036375|mint:P50281|rcsb pdb:1BQQ|rcsb pdb:1BUV|rcsb pdb:2MQS|rcsb pdb:3MA2|rcsb pdb:3X23|rcsb pdb:4P3C|rcsb pdb:4P3D|rcsb pdb:4QXU|rcsb pdb:5H0U|rcsb pdb:6CLZ|rcsb pdb:6CM1|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|rcsb pdb:3C7X|refseq:NP_004986.1|dip:DIP-35111N	refseq:NP_001278909.1|ensembl:ENSG00000160867(gene)|ensembl:ENST00000292408(transcript)|ensembl:ENST00000502906(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010715"(regulation of extracellular matrix disassembly)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030133"(transport vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|mint:P22455|rcsb pdb:1QCT|rcsb pdb:4QQ5|rcsb pdb:4QQC|rcsb pdb:4QQJ|rcsb pdb:4QQT|rcsb pdb:4QRC|rcsb pdb:4R6V|rcsb pdb:4TYE|rcsb pdb:4TYG|rcsb pdb:4TYI|rcsb pdb:4UXQ|rcsb pdb:4XCU|rcsb pdb:5JKG|rcsb pdb:5NUD|rcsb pdb:5NWZ|rcsb pdb:5XFF|rcsb pdb:5XFJ|rcsb pdb:6IUO|rcsb pdb:6IUP|rcsb pdb:6J6Y|rcsb pdb:6JPE|rcsb pdb:6JPJ|rcsb pdb:6NVG|rcsb pdb:6NVH|rcsb pdb:6NVI|rcsb pdb:6NVJ|rcsb pdb:6NVK|rcsb pdb:6V9C|rcsb pdb:6YI8|rcsb pdb:7DTZ|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1307965|reactome:R-HSA-1839128|reactome:R-HSA-190322|reactome:R-HSA-2219530|reactome:R-HSA-5654228|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654733|reactome:R-HSA-5655291|reactome:R-HSA-5673001|reactome:R-HSA-6811558|rcsb pdb:4TYJ|refseq:NP_002002.3|refseq:NP_075252.2|refseq:NP_998812.1|refseq:XP_005265895.1|dip:DIP-5149N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/06	2017/08/10	rogid:x2H2pYgnfBvYy7Stikq3uk+ihhw9606	rogid:JQ3gV5Xg75wwE2tOvcKZ3Vr9Lgg9606	rigid:pga6LK8GBESzzYFdYu8Wo6Eakoc	false	ha tag:n-n	v5 tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P50281	uniprotkb:P22455	intact:EBI-992788|uniprotkb:Q6GSF3|uniprotkb:Q92678|uniprotkb:A8K5L0|ensembl:ENSP00000308208	intact:EBI-6256193|uniprotkb:G3JVM2|uniprotkb:G3JVM5|uniprotkb:G3JVM7|uniprotkb:G3JVM9|uniprotkb:Q96KE5|ensembl:ENSP00000292408|ensembl:ENSP00000424960|uniprotkb:O43785|uniprotkb:Q14309|uniprotkb:Q71TW8|uniprotkb:Q8TDA0	psi-mi:mmp14_human(display_long)|uniprotkb:Membrane-type matrix metalloproteinase 1(gene name synonym)|uniprotkb:Membrane-type-1 matrix metalloproteinase(gene name synonym)|uniprotkb:MMP-X1(gene name synonym)|uniprotkb:MMP14(gene name)|psi-mi:MMP14(display_short)	psi-mi:fgfr4_human(display_long)|uniprotkb:FGFR4(gene name)|psi-mi:FGFR4(display_short)|uniprotkb:JTK2(gene name synonym)|uniprotkb:TKF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sugiyama et al. (2010)	pubmed:20798051|doi:10.1073/pnas.0914459107|imex:IM-17461	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15873363|imex:IM-17461-4|dip:DIP-188614E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000311852(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010831"(positive regulation of myotube differentiation)|ensembl:ENSG00000157227(gene)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016485"(protein processing)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031638"(zymogen activation)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0044354"(macropinosome)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048771"(tissue remodeling)|go:"GO:0048870"(cell motility)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060322"(head development)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0097094"(craniofacial suture morphogenesis)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990834"(response to odorant)|interpro:IPR000585(Hemopexin)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR021805|interpro:IPR024079|interpro:IPR033739|interpro:IPR036365|interpro:IPR036366|interpro:IPR036375|mint:P50281|rcsb pdb:1BQQ|rcsb pdb:1BUV|rcsb pdb:2MQS|rcsb pdb:3MA2|rcsb pdb:3X23|rcsb pdb:4P3C|rcsb pdb:4P3D|rcsb pdb:4QXU|rcsb pdb:5H0U|rcsb pdb:6CLZ|rcsb pdb:6CM1|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|rcsb pdb:3C7X|refseq:NP_004986.1|dip:DIP-35111N	refseq:NP_001278909.1|ensembl:ENSG00000160867(gene)|ensembl:ENST00000292408(transcript)|ensembl:ENST00000502906(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010715"(regulation of extracellular matrix disassembly)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030133"(transport vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|mint:P22455|rcsb pdb:1QCT|rcsb pdb:4QQ5|rcsb pdb:4QQC|rcsb pdb:4QQJ|rcsb pdb:4QQT|rcsb pdb:4QRC|rcsb pdb:4R6V|rcsb pdb:4TYE|rcsb pdb:4TYG|rcsb pdb:4TYI|rcsb pdb:4UXQ|rcsb pdb:4XCU|rcsb pdb:5JKG|rcsb pdb:5NUD|rcsb pdb:5NWZ|rcsb pdb:5XFF|rcsb pdb:5XFJ|rcsb pdb:6IUO|rcsb pdb:6IUP|rcsb pdb:6J6Y|rcsb pdb:6JPE|rcsb pdb:6JPJ|rcsb pdb:6NVG|rcsb pdb:6NVH|rcsb pdb:6NVI|rcsb pdb:6NVJ|rcsb pdb:6NVK|rcsb pdb:6V9C|rcsb pdb:6YI8|rcsb pdb:7DTZ|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1307965|reactome:R-HSA-1839128|reactome:R-HSA-190322|reactome:R-HSA-2219530|reactome:R-HSA-5654228|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654733|reactome:R-HSA-5655291|reactome:R-HSA-5673001|reactome:R-HSA-6811558|rcsb pdb:4TYJ|refseq:NP_002002.3|refseq:NP_075252.2|refseq:NP_998812.1|refseq:XP_005265895.1|dip:DIP-5149N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/06	2017/08/10	rogid:x2H2pYgnfBvYy7Stikq3uk+ihhw9606	rogid:JQ3gV5Xg75wwE2tOvcKZ3Vr9Lgg9606	rigid:pga6LK8GBESzzYFdYu8Wo6Eakoc	false	ha tag:n-n	sufficient binding region:1-764	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P50281	uniprotkb:P22455	intact:EBI-992788|uniprotkb:Q6GSF3|uniprotkb:Q92678|uniprotkb:A8K5L0|ensembl:ENSP00000308208	intact:EBI-6256193|uniprotkb:G3JVM2|uniprotkb:G3JVM5|uniprotkb:G3JVM7|uniprotkb:G3JVM9|uniprotkb:Q96KE5|ensembl:ENSP00000292408|ensembl:ENSP00000424960|uniprotkb:O43785|uniprotkb:Q14309|uniprotkb:Q71TW8|uniprotkb:Q8TDA0	psi-mi:mmp14_human(display_long)|uniprotkb:Membrane-type matrix metalloproteinase 1(gene name synonym)|uniprotkb:Membrane-type-1 matrix metalloproteinase(gene name synonym)|uniprotkb:MMP-X1(gene name synonym)|uniprotkb:MMP14(gene name)|psi-mi:MMP14(display_short)	psi-mi:fgfr4_human(display_long)|uniprotkb:FGFR4(gene name)|psi-mi:FGFR4(display_short)|uniprotkb:JTK2(gene name synonym)|uniprotkb:TKF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sugiyama et al. (2010)	pubmed:20798051|doi:10.1073/pnas.0914459107|imex:IM-17461	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15873422|imex:IM-17461-7|dip:DIP-188614E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000311852(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010831"(positive regulation of myotube differentiation)|ensembl:ENSG00000157227(gene)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016485"(protein processing)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031638"(zymogen activation)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0044354"(macropinosome)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048771"(tissue remodeling)|go:"GO:0048870"(cell motility)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060322"(head development)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0097094"(craniofacial suture morphogenesis)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990834"(response to odorant)|interpro:IPR000585(Hemopexin)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR021805|interpro:IPR024079|interpro:IPR033739|interpro:IPR036365|interpro:IPR036366|interpro:IPR036375|mint:P50281|rcsb pdb:1BQQ|rcsb pdb:1BUV|rcsb pdb:2MQS|rcsb pdb:3MA2|rcsb pdb:3X23|rcsb pdb:4P3C|rcsb pdb:4P3D|rcsb pdb:4QXU|rcsb pdb:5H0U|rcsb pdb:6CLZ|rcsb pdb:6CM1|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|rcsb pdb:3C7X|refseq:NP_004986.1|dip:DIP-35111N	refseq:NP_001278909.1|ensembl:ENSG00000160867(gene)|ensembl:ENST00000292408(transcript)|ensembl:ENST00000502906(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010715"(regulation of extracellular matrix disassembly)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030133"(transport vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|mint:P22455|rcsb pdb:1QCT|rcsb pdb:4QQ5|rcsb pdb:4QQC|rcsb pdb:4QQJ|rcsb pdb:4QQT|rcsb pdb:4QRC|rcsb pdb:4R6V|rcsb pdb:4TYE|rcsb pdb:4TYG|rcsb pdb:4TYI|rcsb pdb:4UXQ|rcsb pdb:4XCU|rcsb pdb:5JKG|rcsb pdb:5NUD|rcsb pdb:5NWZ|rcsb pdb:5XFF|rcsb pdb:5XFJ|rcsb pdb:6IUO|rcsb pdb:6IUP|rcsb pdb:6J6Y|rcsb pdb:6JPE|rcsb pdb:6JPJ|rcsb pdb:6NVG|rcsb pdb:6NVH|rcsb pdb:6NVI|rcsb pdb:6NVJ|rcsb pdb:6NVK|rcsb pdb:6V9C|rcsb pdb:6YI8|rcsb pdb:7DTZ|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1307965|reactome:R-HSA-1839128|reactome:R-HSA-190322|reactome:R-HSA-2219530|reactome:R-HSA-5654228|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654733|reactome:R-HSA-5655291|reactome:R-HSA-5673001|reactome:R-HSA-6811558|rcsb pdb:4TYJ|refseq:NP_002002.3|refseq:NP_075252.2|refseq:NP_998812.1|refseq:XP_005265895.1|dip:DIP-5149N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:x2H2pYgnfBvYy7Stikq3uk+ihhw9606	rogid:JQ3gV5Xg75wwE2tOvcKZ3Vr9Lgg9606	rigid:pga6LK8GBESzzYFdYu8Wo6Eakoc	false	ha tag:n-n|mutation decreasing interaction:573-573|mutation decreasing interaction:240-240	v5 tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)