#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q562F6 uniprotkb:Q53HL2 intact:EBI-989213|ensembl:ENSP00000350447|uniprotkb:Q53RR9|uniprotkb:Q53T20|uniprotkb:Q86XY4|uniprotkb:Q8IWK2|uniprotkb:Q8IZK1|uniprotkb:Q8N1Q5|uniprotkb:Q96LQ3|intact:EBI-2559582 intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4 psi-mi:sgo2_human(display_long)|uniprotkb:SGO2(gene name)|psi-mi:SGO2(display_short)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym)|uniprotkb:Tripin(gene name synonym)|uniprotkb:SGOL2(gene name synonym) psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15872240|imex:IM-16277-1|dip:DIP-187402E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163535(gene)|ensembl:ENST00000357799(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q562F6|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:XP_011509036.1|refseq:NP_001153518.1|refseq:NP_689737.4|refseq:XP_005246402.1|dip:DIP-36615N rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:lj8jTnNLhIEEqgqjvOrIJIS57yc9606 rogid:LdL29UIjy+IvQfWTwvatWPabuq09606 rigid:yiMUIwVJ5bHoOYXUGR4QDl0qQq8 false sufficient binding region:69-116 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q562F6 uniprotkb:Q53HL2 intact:EBI-989213|ensembl:ENSP00000350447|uniprotkb:Q53RR9|uniprotkb:Q53T20|uniprotkb:Q86XY4|uniprotkb:Q8IWK2|uniprotkb:Q8IZK1|uniprotkb:Q8N1Q5|uniprotkb:Q96LQ3|intact:EBI-2559582 intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4 psi-mi:sgo2_human(display_long)|uniprotkb:SGO2(gene name)|psi-mi:SGO2(display_short)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym)|uniprotkb:Tripin(gene name synonym)|uniprotkb:SGOL2(gene name synonym) psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15872310|imex:IM-16277-3|dip:DIP-187402E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163535(gene)|ensembl:ENST00000357799(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q562F6|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:XP_011509036.1|refseq:NP_001153518.1|refseq:NP_689737.4|refseq:XP_005246402.1|dip:DIP-36615N rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:lj8jTnNLhIEEqgqjvOrIJIS57yc9606 rogid:LdL29UIjy+IvQfWTwvatWPabuq09606 rigid:yiMUIwVJ5bHoOYXUGR4QDl0qQq8 false - mutation disrupting interaction strength:219-219,204-204,199-199,189-189,185-185,171-171,106-106 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O59790 uniprotkb:O14064 intact:EBI-7587700|intact:MINT-4782749|ensemblfungi:"SPCC320.13c.1:pep" intact:EBI-15872259|ensemblfungi:"SPCC962.02c.1:pep"|uniprotkb:Q9USG4|uniprotkb:Q9UTZ0 psi-mi:ark1_schpo(display_long)|uniprotkb:ark1(gene name)|psi-mi:ark1(display_short)|uniprotkb:sex1(gene name synonym)|uniprotkb:SPCC320.13c(orf name)|uniprotkb:SPCC330.16(orf name)|uniprotkb:Aurora-related kinase 1(gene name synonym) psi-mi:bir1_schpo(display_long)|uniprotkb:bir1(gene name)|psi-mi:bir1(display_short)|uniprotkb:Chromosome segregation protein cut17(gene name synonym)|uniprotkb:cut17(gene name synonym)|uniprotkb:pbh1(gene name synonym)|uniprotkb:SPCC962.02c(orf name)|uniprotkb:SPCP31B10.10c(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15872291|imex:IM-16277-2|dip:DIP-187397E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:O59790|refseq:NP_001018849.1|ensemblfungi:SPCC320.13c(gene)|ensemblfungi:SPCC320.13c.1(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000939"(inner kinetochore)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005876"(spindle microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033316"(meiotic spindle assembly checkpoint signaling)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034503"(protein localization to nucleolar rDNA repeats)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035175"("histone kinase activity (H3-S10 specific)")|go:"GO:0051233"(spindle midzone)|go:"GO:0051316"(attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120110"(interphase mitotic telomere clustering)|go:"GO:0140273"(repair of mitotic kinetochore microtubule attachment defect)|go:"GO:0140429"(positive regulation of mitotic sister chromatid biorientation)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1903380"(positive regulation of mitotic chromosome condensation)|go:"GO:1904967"(regulation of monopolar spindle attachment to meiosis I kinetochore)|go:"GO:1905561"(positive regulation of kinetochore assembly)|go:"GO:1905824"(positive regulation of mitotic sister chromatid arm separation)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030616|reactome:R-SPO-8854050|dip:DIP-44220N ensemblfungi:SPCC962.02c(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0005876"(spindle microtubule)|go:"GO:0023052"(signaling)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034503"(protein localization to nucleolar rDNA repeats)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0072686"(mitotic spindle)|go:"GO:0140429"(positive regulation of mitotic sister chromatid biorientation)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990385"(meiotic spindle midzone)|go:"GO:1990758"(mitotic sister chromatid biorientation)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|ensemblfungi:SPCC962.02c.1(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|reactome:R-SPO-111469|reactome:R-SPO-5675482|reactome:R-SPO-5689880|refseq:NP_587866.3|dip:DIP-59223N psi-mi:"MI:0465"(dip) crc64:BF15AC7B7571A301|comment:mint|function:Required for the spindle checkpoint attachment response during spindle formation, kinetochore microtubule interactions and chromosome segregation during anaphase. Ark1 activity depends upon cut17 function and phosphorylation. Ark1 with bir1 is required for full-scale association with kinetochores and formation of a complex with mad3. Ark1 is also required for phosphorylation of histone H3 that accompanies chromosome condensation and condensin recruitment to mitotic chromatin. Ark1 with pic1 is required for the execution of cytokinesis crc64:952A6BAFA5C489F4 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)") - 2017/08/06 2017/08/10 rogid:kAO0Utqpw1O90Vc4ESFD4IxkDKA284812 rogid:gTIcqeFPWt4p/0CCquDKwtdG7Yw284812 rigid:xb9Fdw/rp8i/j/O+hMLvZLNQKv0 false green fluorescent protein tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O59790 uniprotkb:Q1MTN3 intact:EBI-7587700|intact:MINT-4782749|ensemblfungi:"SPCC320.13c.1:pep" intact:EBI-15872354|ensemblfungi:"SPBC336.15.1:pep"|uniprotkb:Q9UST0|uniprotkb:Q9Y7L3 psi-mi:ark1_schpo(display_long)|uniprotkb:ark1(gene name)|psi-mi:ark1(display_short)|uniprotkb:sex1(gene name synonym)|uniprotkb:SPCC320.13c(orf name)|uniprotkb:SPCC330.16(orf name)|uniprotkb:Aurora-related kinase 1(gene name synonym) psi-mi:pic1_schpo(display_long)|uniprotkb:pic1(gene name)|psi-mi:pic1(display_short)|uniprotkb:SPBC336.15(orf name)|uniprotkb:SPBC685.01(orf name) psi-mi:"MI:0018"(two hybrid) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15872375|imex:IM-16277-5|dip:DIP-187400E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:O59790|refseq:NP_001018849.1|ensemblfungi:SPCC320.13c(gene)|ensemblfungi:SPCC320.13c.1(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000939"(inner kinetochore)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005876"(spindle microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033316"(meiotic spindle assembly checkpoint signaling)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034503"(protein localization to nucleolar rDNA repeats)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035175"("histone kinase activity (H3-S10 specific)")|go:"GO:0051233"(spindle midzone)|go:"GO:0051316"(attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120110"(interphase mitotic telomere clustering)|go:"GO:0140273"(repair of mitotic kinetochore microtubule attachment defect)|go:"GO:0140429"(positive regulation of mitotic sister chromatid biorientation)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1903380"(positive regulation of mitotic chromosome condensation)|go:"GO:1904967"(regulation of monopolar spindle attachment to meiosis I kinetochore)|go:"GO:1905561"(positive regulation of kinetochore assembly)|go:"GO:1905824"(positive regulation of mitotic sister chromatid arm separation)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030616|reactome:R-SPO-8854050|dip:DIP-44220N ensemblfungi:SPBC336.15(gene)|ensemblfungi:SPBC336.15.1(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0072686"(mitotic spindle)|interpro:IPR005635(Inner centromere protein, ARK binding region)|refseq:NP_596135.2|dip:DIP-59225N psi-mi:"MI:0465"(dip) crc64:BF15AC7B7571A301|comment:mint|function:Required for the spindle checkpoint attachment response during spindle formation, kinetochore microtubule interactions and chromosome segregation during anaphase. Ark1 activity depends upon cut17 function and phosphorylation. Ark1 with bir1 is required for full-scale association with kinetochores and formation of a complex with mad3. Ark1 is also required for phosphorylation of histone H3 that accompanies chromosome condensation and condensin recruitment to mitotic chromatin. Ark1 with pic1 is required for the execution of cytokinesis crc64:510368FCD2E8098C full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:kAO0Utqpw1O90Vc4ESFD4IxkDKA284812 rogid:p8+xSlghRGqfYiOrQ+CBZciG+UU284812 rigid:A4djDMcBc4qj99htVOGFHiKgs1A false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5FBB7 uniprotkb:Q53HL2 intact:EBI-989069|ensembl:ENSP00000263753|ensembl:ENSP00000414129|uniprotkb:Q5FBB4|uniprotkb:Q5FBB5|uniprotkb:Q5FBB6|uniprotkb:Q5FBB8|uniprotkb:Q8N579|uniprotkb:Q8WVL0|uniprotkb:Q9BVA8|uniprotkb:Q9H275|uniprotkb:Q588H5|intact:EBI-2555999 intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4 psi-mi:sgo1_human(display_long)|uniprotkb:SGO1(gene name)|psi-mi:SGO1(display_short)|uniprotkb:SGOL1(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-85(gene name synonym)|uniprotkb:Shugoshin-like 1(gene name synonym) psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15872392|imex:IM-16277-6|dip:DIP-187401E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000129810(gene)|ensembl:ENST00000263753(transcript)|ensembl:ENST00000421451(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0019900"(kinase binding)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0071962"(mitotic sister chromatid cohesion, centromeric)|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR011516(Shugoshin, N-terminal)|interpro:IPR028321|interpro:IPR038889|mint:Q5FBB7|rcsb pdb:3FGA|rcsb pdb:3Q6S|rcsb pdb:4A0I|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:NP_001012409.1|refseq:NP_001012410.1|refseq:NP_001012411.1|refseq:NP_001012412.1|refseq:NP_001012413.1|refseq:NP_001186180.1|refseq:NP_001186181.1|refseq:NP_001186182.1|refseq:NP_001186183.1|refseq:NP_001186184.1|refseq:NP_001186185.1|refseq:NP_001186186.1|refseq:NP_612493.1|refseq:XP_011531675.1|refseq:XP_011531677.1|refseq:XP_011531678.1|refseq:XP_011531679.1|dip:DIP-36614N rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:rTa6IoM9PWfd6qOccSMZy1o0bBU9606 rogid:LdL29UIjy+IvQfWTwvatWPabuq09606 rigid:wHHhNU92O9kJZpmMjWcNSbBRQR0 false sufficient binding region:7-89 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53HL2 uniprotkb:Q5FBB7 intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4 intact:EBI-989069|ensembl:ENSP00000263753|ensembl:ENSP00000414129|uniprotkb:Q5FBB4|uniprotkb:Q5FBB5|uniprotkb:Q5FBB6|uniprotkb:Q5FBB8|uniprotkb:Q8N579|uniprotkb:Q8WVL0|uniprotkb:Q9BVA8|uniprotkb:Q9H275|uniprotkb:Q588H5|intact:EBI-2555999 psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym) psi-mi:sgo1_human(display_long)|uniprotkb:SGO1(gene name)|psi-mi:SGO1(display_short)|uniprotkb:SGOL1(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-85(gene name synonym)|uniprotkb:Shugoshin-like 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15872335|imex:IM-16277-4|dip:DIP-187403E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N ensembl:ENSG00000129810(gene)|ensembl:ENST00000263753(transcript)|ensembl:ENST00000421451(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0019900"(kinase binding)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0071962"(mitotic sister chromatid cohesion, centromeric)|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR011516(Shugoshin, N-terminal)|interpro:IPR028321|interpro:IPR038889|mint:Q5FBB7|rcsb pdb:3FGA|rcsb pdb:3Q6S|rcsb pdb:4A0I|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:NP_001012409.1|refseq:NP_001012410.1|refseq:NP_001012411.1|refseq:NP_001012412.1|refseq:NP_001012413.1|refseq:NP_001186180.1|refseq:NP_001186181.1|refseq:NP_001186182.1|refseq:NP_001186183.1|refseq:NP_001186184.1|refseq:NP_001186185.1|refseq:NP_001186186.1|refseq:NP_612493.1|refseq:XP_011531675.1|refseq:XP_011531677.1|refseq:XP_011531678.1|refseq:XP_011531679.1|dip:DIP-36614N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:LdL29UIjy+IvQfWTwvatWPabuq09606 rogid:rTa6IoM9PWfd6qOccSMZy1o0bBU9606 rigid:aWbkOKct3bJR+CvF590GGR7jHNU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q53HL2 uniprotkb:Q562F6 intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4 intact:EBI-989213|ensembl:ENSP00000350447|uniprotkb:Q53RR9|uniprotkb:Q53T20|uniprotkb:Q86XY4|uniprotkb:Q8IWK2|uniprotkb:Q8IZK1|uniprotkb:Q8N1Q5|uniprotkb:Q96LQ3|intact:EBI-2559582 psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym) psi-mi:sgo2_human(display_long)|uniprotkb:SGO2(gene name)|psi-mi:SGO2(display_short)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym)|uniprotkb:Tripin(gene name synonym)|uniprotkb:SGOL2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15872335|imex:IM-16277-4|dip:DIP-187403E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N ensembl:ENSG00000163535(gene)|ensembl:ENST00000357799(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q562F6|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:XP_011509036.1|refseq:NP_001153518.1|refseq:NP_689737.4|refseq:XP_005246402.1|dip:DIP-36615N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:LdL29UIjy+IvQfWTwvatWPabuq09606 rogid:lj8jTnNLhIEEqgqjvOrIJIS57yc9606 rigid:aWbkOKct3bJR+CvF590GGR7jHNU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q53HL2 uniprotkb:Q96GD4 intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4 intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1 psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym) psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15872335|imex:IM-16277-4|dip:DIP-187403E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:LdL29UIjy+IvQfWTwvatWPabuq09606 rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606 rigid:aWbkOKct3bJR+CvF590GGR7jHNU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O59790 uniprotkb:Q1MTN3 intact:EBI-7587700|intact:MINT-4782749|ensemblfungi:"SPCC320.13c.1:pep" intact:EBI-15872354|ensemblfungi:"SPBC336.15.1:pep"|uniprotkb:Q9UST0|uniprotkb:Q9Y7L3 psi-mi:ark1_schpo(display_long)|uniprotkb:ark1(gene name)|psi-mi:ark1(display_short)|uniprotkb:sex1(gene name synonym)|uniprotkb:SPCC320.13c(orf name)|uniprotkb:SPCC330.16(orf name)|uniprotkb:Aurora-related kinase 1(gene name synonym) psi-mi:pic1_schpo(display_long)|uniprotkb:pic1(gene name)|psi-mi:pic1(display_short)|uniprotkb:SPBC336.15(orf name)|uniprotkb:SPBC685.01(orf name) psi-mi:"MI:0018"(two hybrid) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15872411|imex:IM-16277-7|dip:DIP-187400E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:O59790|refseq:NP_001018849.1|ensemblfungi:SPCC320.13c(gene)|ensemblfungi:SPCC320.13c.1(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000939"(inner kinetochore)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005876"(spindle microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033316"(meiotic spindle assembly checkpoint signaling)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034503"(protein localization to nucleolar rDNA repeats)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035175"("histone kinase activity (H3-S10 specific)")|go:"GO:0051233"(spindle midzone)|go:"GO:0051316"(attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120110"(interphase mitotic telomere clustering)|go:"GO:0140273"(repair of mitotic kinetochore microtubule attachment defect)|go:"GO:0140429"(positive regulation of mitotic sister chromatid biorientation)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1903380"(positive regulation of mitotic chromosome condensation)|go:"GO:1904967"(regulation of monopolar spindle attachment to meiosis I kinetochore)|go:"GO:1905561"(positive regulation of kinetochore assembly)|go:"GO:1905824"(positive regulation of mitotic sister chromatid arm separation)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030616|reactome:R-SPO-8854050|dip:DIP-44220N ensemblfungi:SPBC336.15(gene)|ensemblfungi:SPBC336.15.1(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0072686"(mitotic spindle)|interpro:IPR005635(Inner centromere protein, ARK binding region)|refseq:NP_596135.2|dip:DIP-59225N psi-mi:"MI:0465"(dip) crc64:BF15AC7B7571A301|comment:mint|function:Required for the spindle checkpoint attachment response during spindle formation, kinetochore microtubule interactions and chromosome segregation during anaphase. Ark1 activity depends upon cut17 function and phosphorylation. Ark1 with bir1 is required for full-scale association with kinetochores and formation of a complex with mad3. Ark1 is also required for phosphorylation of histone H3 that accompanies chromosome condensation and condensin recruitment to mitotic chromatin. Ark1 with pic1 is required for the execution of cytokinesis crc64:510368FCD2E8098C full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:kAO0Utqpw1O90Vc4ESFD4IxkDKA284812 rogid:p8+xSlghRGqfYiOrQ+CBZciG+UU284812 rigid:A4djDMcBc4qj99htVOGFHiKgs1A false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O13734 uniprotkb:O14064 intact:EBI-15872428|ensemblfungi:"SPAC15A10.15.1:pep"|uniprotkb:Q9UU02 intact:EBI-15872259|ensemblfungi:"SPCC962.02c.1:pep"|uniprotkb:Q9USG4|uniprotkb:Q9UTZ0 psi-mi:sgo2_schpo(display_long)|uniprotkb:sgo2(gene name)|psi-mi:sgo2(display_short)|uniprotkb:SPAC15A10.15(orf name) psi-mi:bir1_schpo(display_long)|uniprotkb:bir1(gene name)|psi-mi:bir1(display_short)|uniprotkb:Chromosome segregation protein cut17(gene name synonym)|uniprotkb:cut17(gene name synonym)|uniprotkb:pbh1(gene name synonym)|uniprotkb:SPCC962.02c(orf name)|uniprotkb:SPCP31B10.10c(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15872449|imex:IM-16277-8|dip:DIP-187398E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:SPAC15A10.15(gene)|ensemblfungi:SPAC15A10.15.1(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0140463"(chromatin-protein adaptor)|go:"GO:1903467"(negative regulation of mitotic DNA replication initiation)|go:"GO:1990758"(mitotic sister chromatid biorientation)|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR011516(Shugoshin, N-terminal)|interpro:IPR038889|refseq:NP_594301.1|dip:DIP-59226N ensemblfungi:SPCC962.02c(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0005876"(spindle microtubule)|go:"GO:0023052"(signaling)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034503"(protein localization to nucleolar rDNA repeats)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0072686"(mitotic spindle)|go:"GO:0140429"(positive regulation of mitotic sister chromatid biorientation)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990385"(meiotic spindle midzone)|go:"GO:1990758"(mitotic sister chromatid biorientation)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|ensemblfungi:SPCC962.02c.1(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|reactome:R-SPO-111469|reactome:R-SPO-5675482|reactome:R-SPO-5689880|refseq:NP_587866.3|dip:DIP-59223N psi-mi:"MI:0465"(dip) crc64:23E909737AFA4B2B crc64:952A6BAFA5C489F4 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)") - 2017/08/06 2017/08/10 rogid:r4Lhf2qyDeA+BqTVEtbWYkF3UR0284812 rogid:gTIcqeFPWt4p/0CCquDKwtdG7Yw284812 rigid:M1X1gpL3t4Lh9u/pTleoiR2j0mU false myc tag:c-c mutation disrupting interaction:908-908,831-831,393-393,294-294,278-278,244-244,229-229,202-202 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q53HL2 uniprotkb:O15392 intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4 intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6 psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym) psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym) psi-mi:"MI:0018"(two hybrid) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15872478|imex:IM-16277-9|dip:DIP-67189E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:LdL29UIjy+IvQfWTwvatWPabuq09606 rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606 rigid:NuDNBH51waO6mRz0f+4CkZzrPik false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53HL2 uniprotkb:Q96GD4 intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4 intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1 psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym) psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15872495|imex:IM-16277-10|dip:DIP-84717E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:LdL29UIjy+IvQfWTwvatWPabuq09606 rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606 rigid:IQJ+VXyLWV9GtSBNFeaKc97jOMw false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q53HL2 uniprotkb:O15392 intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4 intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6 psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym) psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym) psi-mi:"MI:0018"(two hybrid) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15872512|imex:IM-16277-11|dip:DIP-67189E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:LdL29UIjy+IvQfWTwvatWPabuq09606 rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606 rigid:NuDNBH51waO6mRz0f+4CkZzrPik false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NQS7 uniprotkb:Q96GD4 intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295 intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1 psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short) psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym) psi-mi:"MI:0018"(two hybrid) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15872529|imex:IM-16277-12|dip:DIP-67193E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606 rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606 rigid:9tF4MrDYK8QEbZnmITHpI8WXsR4 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O13734 uniprotkb:O14064 intact:EBI-15872428|ensemblfungi:"SPAC15A10.15.1:pep"|uniprotkb:Q9UU02 intact:EBI-15872259|ensemblfungi:"SPCC962.02c.1:pep"|uniprotkb:Q9USG4|uniprotkb:Q9UTZ0 psi-mi:sgo2_schpo(display_long)|uniprotkb:sgo2(gene name)|psi-mi:sgo2(display_short)|uniprotkb:SPAC15A10.15(orf name) psi-mi:bir1_schpo(display_long)|uniprotkb:bir1(gene name)|psi-mi:bir1(display_short)|uniprotkb:Chromosome segregation protein cut17(gene name synonym)|uniprotkb:cut17(gene name synonym)|uniprotkb:pbh1(gene name synonym)|uniprotkb:SPCC962.02c(orf name)|uniprotkb:SPCP31B10.10c(orf name) psi-mi:"MI:0018"(two hybrid) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15872546|imex:IM-16277-13|dip:DIP-187398E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:SPAC15A10.15(gene)|ensemblfungi:SPAC15A10.15.1(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0140463"(chromatin-protein adaptor)|go:"GO:1903467"(negative regulation of mitotic DNA replication initiation)|go:"GO:1990758"(mitotic sister chromatid biorientation)|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR011516(Shugoshin, N-terminal)|interpro:IPR038889|refseq:NP_594301.1|dip:DIP-59226N ensemblfungi:SPCC962.02c(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0005876"(spindle microtubule)|go:"GO:0023052"(signaling)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034503"(protein localization to nucleolar rDNA repeats)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0072686"(mitotic spindle)|go:"GO:0140429"(positive regulation of mitotic sister chromatid biorientation)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990385"(meiotic spindle midzone)|go:"GO:1990758"(mitotic sister chromatid biorientation)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|ensemblfungi:SPCC962.02c.1(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|reactome:R-SPO-111469|reactome:R-SPO-5675482|reactome:R-SPO-5689880|refseq:NP_587866.3|dip:DIP-59223N psi-mi:"MI:0465"(dip) crc64:23E909737AFA4B2B crc64:952A6BAFA5C489F4 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:r4Lhf2qyDeA+BqTVEtbWYkF3UR0284812 rogid:gTIcqeFPWt4p/0CCquDKwtdG7Yw284812 rigid:M1X1gpL3t4Lh9u/pTleoiR2j0mU false sufficient binding region:10-63 binding-associated region:1-300 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53HL2 uniprotkb:Q9NQS7 intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4 intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295 psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym) psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15872567|imex:IM-16277-14|dip:DIP-67191E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:LdL29UIjy+IvQfWTwvatWPabuq09606 rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606 rigid:E4GiFkYn5a9mW6C/zqRYxKbTwYM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q53HL2 uniprotkb:Q96GD4 intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4 intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1 psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym) psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15872567|imex:IM-16277-14|dip:DIP-67191E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:LdL29UIjy+IvQfWTwvatWPabuq09606 rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606 rigid:E4GiFkYn5a9mW6C/zqRYxKbTwYM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q53HL2 uniprotkb:O15392 intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4 intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6 psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym) psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15872567|imex:IM-16277-14|dip:DIP-67191E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:LdL29UIjy+IvQfWTwvatWPabuq09606 rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606 rigid:E4GiFkYn5a9mW6C/zqRYxKbTwYM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O13734 uniprotkb:O14064 intact:EBI-15872428|ensemblfungi:"SPAC15A10.15.1:pep"|uniprotkb:Q9UU02 intact:EBI-15872259|ensemblfungi:"SPCC962.02c.1:pep"|uniprotkb:Q9USG4|uniprotkb:Q9UTZ0 psi-mi:sgo2_schpo(display_long)|uniprotkb:sgo2(gene name)|psi-mi:sgo2(display_short)|uniprotkb:SPAC15A10.15(orf name) psi-mi:bir1_schpo(display_long)|uniprotkb:bir1(gene name)|psi-mi:bir1(display_short)|uniprotkb:Chromosome segregation protein cut17(gene name synonym)|uniprotkb:cut17(gene name synonym)|uniprotkb:pbh1(gene name synonym)|uniprotkb:SPCC962.02c(orf name)|uniprotkb:SPCP31B10.10c(orf name) psi-mi:"MI:0018"(two hybrid) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15872648|imex:IM-16277-18|dip:DIP-187398E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:SPAC15A10.15(gene)|ensemblfungi:SPAC15A10.15.1(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0140463"(chromatin-protein adaptor)|go:"GO:1903467"(negative regulation of mitotic DNA replication initiation)|go:"GO:1990758"(mitotic sister chromatid biorientation)|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR011516(Shugoshin, N-terminal)|interpro:IPR038889|refseq:NP_594301.1|dip:DIP-59226N ensemblfungi:SPCC962.02c(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0005876"(spindle microtubule)|go:"GO:0023052"(signaling)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034503"(protein localization to nucleolar rDNA repeats)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0072686"(mitotic spindle)|go:"GO:0140429"(positive regulation of mitotic sister chromatid biorientation)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990385"(meiotic spindle midzone)|go:"GO:1990758"(mitotic sister chromatid biorientation)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|ensemblfungi:SPCC962.02c.1(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|reactome:R-SPO-111469|reactome:R-SPO-5675482|reactome:R-SPO-5689880|refseq:NP_587866.3|dip:DIP-59223N psi-mi:"MI:0465"(dip) crc64:23E909737AFA4B2B crc64:952A6BAFA5C489F4 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:r4Lhf2qyDeA+BqTVEtbWYkF3UR0284812 rogid:gTIcqeFPWt4p/0CCquDKwtdG7Yw284812 rigid:M1X1gpL3t4Lh9u/pTleoiR2j0mU false - binding-associated region:1-300|mutation disrupting interaction:294-294,278-278,244-244,229-229,202-202 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5FBB7 uniprotkb:Q53HL2 intact:EBI-989069|ensembl:ENSP00000263753|ensembl:ENSP00000414129|uniprotkb:Q5FBB4|uniprotkb:Q5FBB5|uniprotkb:Q5FBB6|uniprotkb:Q5FBB8|uniprotkb:Q8N579|uniprotkb:Q8WVL0|uniprotkb:Q9BVA8|uniprotkb:Q9H275|uniprotkb:Q588H5|intact:EBI-2555999 intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4 psi-mi:sgo1_human(display_long)|uniprotkb:SGO1(gene name)|psi-mi:SGO1(display_short)|uniprotkb:SGOL1(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-85(gene name synonym)|uniprotkb:Shugoshin-like 1(gene name synonym) psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15872623|imex:IM-16277-17|dip:DIP-187401E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000129810(gene)|ensembl:ENST00000263753(transcript)|ensembl:ENST00000421451(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0019900"(kinase binding)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0071962"(mitotic sister chromatid cohesion, centromeric)|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR011516(Shugoshin, N-terminal)|interpro:IPR028321|interpro:IPR038889|mint:Q5FBB7|rcsb pdb:3FGA|rcsb pdb:3Q6S|rcsb pdb:4A0I|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:NP_001012409.1|refseq:NP_001012410.1|refseq:NP_001012411.1|refseq:NP_001012412.1|refseq:NP_001012413.1|refseq:NP_001186180.1|refseq:NP_001186181.1|refseq:NP_001186182.1|refseq:NP_001186183.1|refseq:NP_001186184.1|refseq:NP_001186185.1|refseq:NP_001186186.1|refseq:NP_612493.1|refseq:XP_011531675.1|refseq:XP_011531677.1|refseq:XP_011531678.1|refseq:XP_011531679.1|dip:DIP-36614N rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:rTa6IoM9PWfd6qOccSMZy1o0bBU9606 rogid:LdL29UIjy+IvQfWTwvatWPabuq09606 rigid:wHHhNU92O9kJZpmMjWcNSbBRQR0 false - mutation disrupting interaction strength:219-219,204-204,199-199,189-189,185-185,171-171,106-106 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q10428 uniprotkb:Q9P7A0 intact:EBI-989357|ensemblfungi:"SPCC188.02.1:pep" intact:EBI-989427|ensemblfungi:"SPBP35G2.03c.1:pep" psi-mi:2ad1_schpo(display_long)|uniprotkb:PP2A, B subunit, B' delta 1 isoform(gene name synonym)|uniprotkb:par1(gene name)|psi-mi:par1(display_short)|uniprotkb:pbp1(gene name synonym)|uniprotkb:SPCC188.02(orf name) psi-mi:sgo1_schpo(display_long)|uniprotkb:sgo1(gene name)|psi-mi:sgo1(display_short)|uniprotkb:SPBP35G2.03c(orf name) psi-mi:"MI:0018"(two hybrid) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15872606|imex:IM-16277-16|dip:DIP-65108E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:SPCC188.02(gene)|ensemblfungi:SPCC188.02.1(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000939"(inner kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031030"(negative regulation of septation initiation signaling)|go:"GO:0031568"(mitotic G1 cell size control checkpoint signaling)|go:"GO:0032153"(cell division site)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0072687"(meiotic spindle)|go:"GO:0110085"(mitotic actomyosin contractile ring)|go:"GO:1990813"(meiotic centromeric cohesion protection)|interpro:IPR002554(Protein phosphatase 2A, regulatory B subunit, B56)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|refseq:NP_588206.1|reactome:R-SPO-198753|reactome:R-SPO-202670|dip:DIP-36612N|reactome:R-SPO-389513|reactome:R-SPO-6811558 ensemblfungi:SPBP35G2.03c(gene)|ensemblfungi:SPBP35G2.03c.1(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000939"(inner kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0045144"(meiotic sister chromatid segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051455"(monopolar spindle attachment to meiosis I kinetochore)|go:"GO:0072687"(meiotic spindle)|go:"GO:0140311"(protein sequestering activity)|go:"GO:0140483"(kinetochore adaptor activity)|go:"GO:1990813"(meiotic centromeric cohesion protection)|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR011516(Shugoshin, N-terminal)|interpro:IPR038889|refseq:NP_595378.1|dip:DIP-36613N psi-mi:"MI:0465"(dip) crc64:A15FD882D516F88A crc64:32F52DD0A1E0542A full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:jSWj2r4tKur8yjSlGykRl02ZbcI284812 rogid:Cl0eHeFpiai8Kwj7IJQTY/MIgaE284812 rigid:WAYHVgihsKMYLqCof5zDyE4eS5w false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53HL2 uniprotkb:Q96GD4 intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4 intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1 psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym) psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15872586|imex:IM-16277-15|dip:DIP-68886E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:LdL29UIjy+IvQfWTwvatWPabuq09606 rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606 rigid:n43T692KHXz/G5iN1tEJy0egmIU false green fluorescent protein tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q53HL2 uniprotkb:O15392 intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4 intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6 psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym) psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15872586|imex:IM-16277-15|dip:DIP-68886E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:LdL29UIjy+IvQfWTwvatWPabuq09606 rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606 rigid:n43T692KHXz/G5iN1tEJy0egmIU false green fluorescent protein tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O94328 uniprotkb:O14064 intact:EBI-15872674|ensemblfungi:"SPBC725.12.1:pep" intact:EBI-15872259|ensemblfungi:"SPCC962.02c.1:pep"|uniprotkb:Q9USG4|uniprotkb:Q9UTZ0 psi-mi:mu118_schpo(display_long)|uniprotkb:mug118(gene name)|psi-mi:mug118(display_short)|uniprotkb:SPBC725.12(orf name) psi-mi:bir1_schpo(display_long)|uniprotkb:bir1(gene name)|psi-mi:bir1(display_short)|uniprotkb:Chromosome segregation protein cut17(gene name synonym)|uniprotkb:cut17(gene name synonym)|uniprotkb:pbh1(gene name synonym)|uniprotkb:SPCC962.02c(orf name)|uniprotkb:SPCP31B10.10c(orf name) psi-mi:"MI:0018"(two hybrid) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15872691|imex:IM-16277-19|dip:DIP-187399E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:SPBC725.12(gene)|ensemblfungi:SPBC725.12.1(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0051233"(spindle midzone)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0072686"(mitotic spindle)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR018851|refseq:NP_595492.2|dip:DIP-59224N ensemblfungi:SPCC962.02c(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0005876"(spindle microtubule)|go:"GO:0023052"(signaling)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034503"(protein localization to nucleolar rDNA repeats)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0072686"(mitotic spindle)|go:"GO:0140429"(positive regulation of mitotic sister chromatid biorientation)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990385"(meiotic spindle midzone)|go:"GO:1990758"(mitotic sister chromatid biorientation)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|ensemblfungi:SPCC962.02c.1(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|reactome:R-SPO-111469|reactome:R-SPO-5675482|reactome:R-SPO-5689880|refseq:NP_587866.3|dip:DIP-59223N psi-mi:"MI:0465"(dip) crc64:CF82BD195CFD6101 crc64:952A6BAFA5C489F4 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:c8gMlHICLIK5oU0oU0kj2w+rvEw284812 rogid:gTIcqeFPWt4p/0CCquDKwtdG7Yw284812 rigid:Cnmf3DYqb5h3n+a7UuXPsORdisY false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NQS7 uniprotkb:Q96GD4 intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295 intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1 psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short) psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym) psi-mi:"MI:0018"(two hybrid) Tsukahara et al. (2010) pubmed:20739936|doi:10.1038/nature09390|imex:IM-16277 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15872708|imex:IM-16277-20|dip:DIP-67193E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606 rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606 rigid:9tF4MrDYK8QEbZnmITHpI8WXsR4 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)