#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O88846	uniprotkb:P27695	intact:EBI-7258907|intact:UNK-5367033|ensembl:ENSRNOP00000019555	intact:EBI-1048805|uniprotkb:Q969L5|uniprotkb:Q99775|ensembl:ENSP00000216714|ensembl:ENSP00000381111|ensembl:ENSP00000451979	psi-mi:rnf4_rat(display_long)|uniprotkb:RING finger protein 4(gene name synonym)|uniprotkb:Small nuclear ring finger protein(gene name synonym)|uniprotkb:Snurf(gene name synonym)|uniprotkb:Rnf4(gene name)|psi-mi:Rnf4(display_short)|uniprotkb:RING-type E3 ubiquitin transferase RNF4(gene name synonym)	psi-mi:apex1_human(display_long)|uniprotkb:Apurinic-apyrimidinic endonuclease 1(gene name synonym)|uniprotkb:APEX nuclease(gene name synonym)|uniprotkb:APE1(gene name synonym)|uniprotkb:APEX1(gene name)|psi-mi:APEX1(display_short)|uniprotkb:APE(gene name synonym)|uniprotkb:APEX(gene name synonym)|uniprotkb:APX(gene name synonym)|uniprotkb:HAP1(gene name synonym)|uniprotkb:REF1(gene name synonym)|uniprotkb:REF-1(gene name synonym)|uniprotkb:Redox factor-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2010)	pubmed:20696907|doi:10.1073/pnas.1009025107|imex:IM-16467	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15869916|imex:IM-16467-1|dip:DIP-187709E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008768493.1|refseq:XP_008768494.1|refseq:XP_008768495.1|refseq:NP_062055.1|rgd:3583|ensembl:ENSRNOG00000013930(gene)|ensembl:ENSRNOT00000019555(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0016605"(PML body)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032184"(SUMO polymer binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044752"(response to human chorionic gonadotropin)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090234"(regulation of kinetochore assembly)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR043295|rcsb pdb:3NG2|rcsb pdb:4AP4|rcsb pdb:5AIT|rcsb pdb:5AIU|reactome:R-RNO-983168|refseq:XP_017454634.1|refseq:XP_017454635.1	refseq:NP_001632.2|refseq:NP_542379.1|refseq:NP_542380.1|refseq:NP_001231178.1|ensembl:ENSG00000100823(gene)|ensembl:ENST00000216714(transcript)|ensembl:ENST00000398030(transcript)|ensembl:ENST00000555414(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004528"(phosphodiesterase I activity)|go:"GO:0004844"(uracil DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005840"(ribosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006310"(DNA recombination)|go:"GO:0007568"(aging)|go:"GO:0008081"(phosphoric diester hydrolase activity)|go:"GO:0008309"(double-stranded DNA exodeoxyribonuclease activity)|go:"GO:0008311"(double-stranded DNA 3'-5' exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016890"(site-specific endodeoxyribonuclease activity, specific for altered base)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0080111"(DNA demethylation)|go:"GO:0097698"(telomere maintenance via base-excision repair)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004808(Exodeoxyribonuclease III xth)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR020847|interpro:IPR020848|interpro:IPR036691|mint:P27695|rcsb pdb:1BIX|rcsb pdb:1CQG|rcsb pdb:1CQH|rcsb pdb:1DE8|rcsb pdb:1DE9|rcsb pdb:1DEW|rcsb pdb:1E9N|rcsb pdb:1HD7|rcsb pdb:2ISI|rcsb pdb:2O3H|rcsb pdb:3U8U|rcsb pdb:4IEM|rcsb pdb:4LND|rcsb pdb:4QH9|rcsb pdb:4QHD|rcsb pdb:4QHE|rcsb pdb:5CFG|rcsb pdb:5DFF|rcsb pdb:5DFH|rcsb pdb:5DFI|rcsb pdb:5DFJ|rcsb pdb:5DG0|rcsb pdb:5WN0|rcsb pdb:5WN1|rcsb pdb:5WN2|rcsb pdb:5WN3|rcsb pdb:5WN4|rcsb pdb:5WN5|rcsb pdb:6BOQ|rcsb pdb:6BOR|rcsb pdb:6BOS|rcsb pdb:6BOT|rcsb pdb:6BOU|rcsb pdb:6BOV|rcsb pdb:6BOW|rcsb pdb:6MK3|rcsb pdb:6MKK|rcsb pdb:6MKM|rcsb pdb:6MKO|rcsb pdb:6P93|rcsb pdb:6P94|rcsb pdb:6W0Q|rcsb pdb:6W2P|rcsb pdb:6W3L|rcsb pdb:6W3N|rcsb pdb:6W3Q|rcsb pdb:6W3U|rcsb pdb:6W43|rcsb pdb:6W4I|rcsb pdb:6W4T|reactome:R-HSA-110357|reactome:R-HSA-110362|reactome:R-HSA-110373|reactome:R-HSA-5651801|reactome:R-HSA-73930|reactome:R-HSA-73933|dip:DIP-6130N	psi-mi:"MI:0465"(dip)	comment:mint|function:Enhances steroid receptor-mediated transcriptional activation as well as activating basal transcription	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:sxkdS+nFno7SrUQ0BNj5sy+K9IE10116	rogid:418z7Qhlcop0UKIfNQse+iyM8gg9606	rigid:zUv2+/3aD0592ECI2+272ofJTXU	false	sufficient binding region:1-100|flag tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O88846	uniprotkb:Q13569	intact:EBI-7258907|intact:UNK-5367033|ensembl:ENSRNOP00000019555	intact:EBI-348333|ensembl:ENSP00000376611|uniprotkb:Q8IUZ6|uniprotkb:Q8IZM3	psi-mi:rnf4_rat(display_long)|uniprotkb:RING finger protein 4(gene name synonym)|uniprotkb:Small nuclear ring finger protein(gene name synonym)|uniprotkb:Snurf(gene name synonym)|uniprotkb:Rnf4(gene name)|psi-mi:Rnf4(display_short)|uniprotkb:RING-type E3 ubiquitin transferase RNF4(gene name synonym)	psi-mi:tdg_human(display_long)|uniprotkb:TDG(gene name)|psi-mi:TDG(display_short)|uniprotkb:Thymine-DNA glycosylase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2010)	pubmed:20696907|doi:10.1073/pnas.1009025107|imex:IM-16467	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15869916|imex:IM-16467-1|dip:DIP-187709E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008768493.1|refseq:XP_008768494.1|refseq:XP_008768495.1|refseq:NP_062055.1|rgd:3583|ensembl:ENSRNOG00000013930(gene)|ensembl:ENSRNOT00000019555(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0016605"(PML body)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032184"(SUMO polymer binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044752"(response to human chorionic gonadotropin)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090234"(regulation of kinetochore assembly)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR043295|rcsb pdb:3NG2|rcsb pdb:4AP4|rcsb pdb:5AIT|rcsb pdb:5AIU|reactome:R-RNO-983168|refseq:XP_017454634.1|refseq:XP_017454635.1	ensembl:ENSG00000139372(gene)|ensembl:ENST00000392872(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004844"(uracil DNA N-glycosylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006284"(base-excision repair)|go:"GO:0006285"(base-excision repair, AP site formation)|go:"GO:0006298"(mismatch repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0008263"(pyrimidine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0019104"(DNA N-glycosylase activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0031402"(sodium ion binding)|go:"GO:0031404"(chloride ion binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0035511"(oxidative DNA demethylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043739"(G/U mismatch-specific uracil-DNA glycosylase activity)|go:"GO:0045008"(depyrimidination)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0080111"(DNA demethylation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902544"(regulation of DNA N-glycosylase activity)|interpro:IPR003310("G:T/U mismatch-specific DNA glycosylase")|interpro:IPR005122(Uracil-DNA glycosylase-like)|interpro:IPR015637(DNA glycosylase, G/T mismatch)|interpro:IPR036895|mint:Q13569|rcsb pdb:1WYW|rcsb pdb:2D07|rcsb pdb:2RBA|rcsb pdb:3UFJ|rcsb pdb:3UO7|rcsb pdb:3UOB|rcsb pdb:4FNC|rcsb pdb:4JGC|rcsb pdb:4XEG|rcsb pdb:4Z3A|rcsb pdb:4Z47|rcsb pdb:4Z7B|rcsb pdb:4Z7Z|rcsb pdb:5CYS|rcsb pdb:5FF8|rcsb pdb:5HF7|rcsb pdb:5JXY|rcsb pdb:5T2W|rcsb pdb:6U15|rcsb pdb:6U16|rcsb pdb:6U17|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110357|reactome:R-HSA-3108214|reactome:R-HSA-5221030|refseq:NP_003202.3|dip:DIP-32709N	psi-mi:"MI:0465"(dip)	comment:mint|function:Enhances steroid receptor-mediated transcriptional activation as well as activating basal transcription	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:sxkdS+nFno7SrUQ0BNj5sy+K9IE10116	rogid:LPhuo6buYUphV9aJ456Ydq36fnU9606	rigid:zUv2+/3aD0592ECI2+272ofJTXU	false	sufficient binding region:1-100|flag tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O88846	uniprotkb:P27695	intact:EBI-7258907|intact:UNK-5367033|ensembl:ENSRNOP00000019555	intact:EBI-1048805|uniprotkb:Q969L5|uniprotkb:Q99775|ensembl:ENSP00000216714|ensembl:ENSP00000381111|ensembl:ENSP00000451979	psi-mi:rnf4_rat(display_long)|uniprotkb:RING finger protein 4(gene name synonym)|uniprotkb:Small nuclear ring finger protein(gene name synonym)|uniprotkb:Snurf(gene name synonym)|uniprotkb:Rnf4(gene name)|psi-mi:Rnf4(display_short)|uniprotkb:RING-type E3 ubiquitin transferase RNF4(gene name synonym)	psi-mi:apex1_human(display_long)|uniprotkb:Apurinic-apyrimidinic endonuclease 1(gene name synonym)|uniprotkb:APEX nuclease(gene name synonym)|uniprotkb:APE1(gene name synonym)|uniprotkb:APEX1(gene name)|psi-mi:APEX1(display_short)|uniprotkb:APE(gene name synonym)|uniprotkb:APEX(gene name synonym)|uniprotkb:APX(gene name synonym)|uniprotkb:HAP1(gene name synonym)|uniprotkb:REF1(gene name synonym)|uniprotkb:REF-1(gene name synonym)|uniprotkb:Redox factor-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2010)	pubmed:20696907|doi:10.1073/pnas.1009025107|imex:IM-16467	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15869938|imex:IM-16467-2|dip:DIP-187711E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008768493.1|refseq:XP_008768494.1|refseq:XP_008768495.1|refseq:NP_062055.1|rgd:3583|ensembl:ENSRNOG00000013930(gene)|ensembl:ENSRNOT00000019555(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0016605"(PML body)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032184"(SUMO polymer binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044752"(response to human chorionic gonadotropin)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090234"(regulation of kinetochore assembly)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR043295|rcsb pdb:3NG2|rcsb pdb:4AP4|rcsb pdb:5AIT|rcsb pdb:5AIU|reactome:R-RNO-983168|refseq:XP_017454634.1|refseq:XP_017454635.1	refseq:NP_001632.2|refseq:NP_542379.1|refseq:NP_542380.1|refseq:NP_001231178.1|ensembl:ENSG00000100823(gene)|ensembl:ENST00000216714(transcript)|ensembl:ENST00000398030(transcript)|ensembl:ENST00000555414(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004528"(phosphodiesterase I activity)|go:"GO:0004844"(uracil DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005840"(ribosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006310"(DNA recombination)|go:"GO:0007568"(aging)|go:"GO:0008081"(phosphoric diester hydrolase activity)|go:"GO:0008309"(double-stranded DNA exodeoxyribonuclease activity)|go:"GO:0008311"(double-stranded DNA 3'-5' exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016890"(site-specific endodeoxyribonuclease activity, specific for altered base)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0080111"(DNA demethylation)|go:"GO:0097698"(telomere maintenance via base-excision repair)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004808(Exodeoxyribonuclease III xth)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR020847|interpro:IPR020848|interpro:IPR036691|mint:P27695|rcsb pdb:1BIX|rcsb pdb:1CQG|rcsb pdb:1CQH|rcsb pdb:1DE8|rcsb pdb:1DE9|rcsb pdb:1DEW|rcsb pdb:1E9N|rcsb pdb:1HD7|rcsb pdb:2ISI|rcsb pdb:2O3H|rcsb pdb:3U8U|rcsb pdb:4IEM|rcsb pdb:4LND|rcsb pdb:4QH9|rcsb pdb:4QHD|rcsb pdb:4QHE|rcsb pdb:5CFG|rcsb pdb:5DFF|rcsb pdb:5DFH|rcsb pdb:5DFI|rcsb pdb:5DFJ|rcsb pdb:5DG0|rcsb pdb:5WN0|rcsb pdb:5WN1|rcsb pdb:5WN2|rcsb pdb:5WN3|rcsb pdb:5WN4|rcsb pdb:5WN5|rcsb pdb:6BOQ|rcsb pdb:6BOR|rcsb pdb:6BOS|rcsb pdb:6BOT|rcsb pdb:6BOU|rcsb pdb:6BOV|rcsb pdb:6BOW|rcsb pdb:6MK3|rcsb pdb:6MKK|rcsb pdb:6MKM|rcsb pdb:6MKO|rcsb pdb:6P93|rcsb pdb:6P94|rcsb pdb:6W0Q|rcsb pdb:6W2P|rcsb pdb:6W3L|rcsb pdb:6W3N|rcsb pdb:6W3Q|rcsb pdb:6W3U|rcsb pdb:6W43|rcsb pdb:6W4I|rcsb pdb:6W4T|reactome:R-HSA-110357|reactome:R-HSA-110362|reactome:R-HSA-110373|reactome:R-HSA-5651801|reactome:R-HSA-73930|reactome:R-HSA-73933|dip:DIP-6130N	psi-mi:"MI:0465"(dip)	comment:mint|function:Enhances steroid receptor-mediated transcriptional activation as well as activating basal transcription	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:sxkdS+nFno7SrUQ0BNj5sy+K9IE10116	rogid:418z7Qhlcop0UKIfNQse+iyM8gg9606	rigid:9KsBaA7KnHi0mW7eG7Fs5/pDIMU	false	flag tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O88846	uniprotkb:Q13569	intact:EBI-7258907|intact:UNK-5367033|ensembl:ENSRNOP00000019555	intact:EBI-348333|ensembl:ENSP00000376611|uniprotkb:Q8IUZ6|uniprotkb:Q8IZM3	psi-mi:rnf4_rat(display_long)|uniprotkb:RING finger protein 4(gene name synonym)|uniprotkb:Small nuclear ring finger protein(gene name synonym)|uniprotkb:Snurf(gene name synonym)|uniprotkb:Rnf4(gene name)|psi-mi:Rnf4(display_short)|uniprotkb:RING-type E3 ubiquitin transferase RNF4(gene name synonym)	psi-mi:tdg_human(display_long)|uniprotkb:TDG(gene name)|psi-mi:TDG(display_short)|uniprotkb:Thymine-DNA glycosylase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2010)	pubmed:20696907|doi:10.1073/pnas.1009025107|imex:IM-16467	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15869959|imex:IM-16467-3|dip:DIP-187710E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008768493.1|refseq:XP_008768494.1|refseq:XP_008768495.1|refseq:NP_062055.1|rgd:3583|ensembl:ENSRNOG00000013930(gene)|ensembl:ENSRNOT00000019555(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0016605"(PML body)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032184"(SUMO polymer binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044752"(response to human chorionic gonadotropin)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090234"(regulation of kinetochore assembly)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR043295|rcsb pdb:3NG2|rcsb pdb:4AP4|rcsb pdb:5AIT|rcsb pdb:5AIU|reactome:R-RNO-983168|refseq:XP_017454634.1|refseq:XP_017454635.1	ensembl:ENSG00000139372(gene)|ensembl:ENST00000392872(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004844"(uracil DNA N-glycosylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006284"(base-excision repair)|go:"GO:0006285"(base-excision repair, AP site formation)|go:"GO:0006298"(mismatch repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0008263"(pyrimidine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0019104"(DNA N-glycosylase activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0031402"(sodium ion binding)|go:"GO:0031404"(chloride ion binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0035511"(oxidative DNA demethylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043739"(G/U mismatch-specific uracil-DNA glycosylase activity)|go:"GO:0045008"(depyrimidination)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0080111"(DNA demethylation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902544"(regulation of DNA N-glycosylase activity)|interpro:IPR003310("G:T/U mismatch-specific DNA glycosylase")|interpro:IPR005122(Uracil-DNA glycosylase-like)|interpro:IPR015637(DNA glycosylase, G/T mismatch)|interpro:IPR036895|mint:Q13569|rcsb pdb:1WYW|rcsb pdb:2D07|rcsb pdb:2RBA|rcsb pdb:3UFJ|rcsb pdb:3UO7|rcsb pdb:3UOB|rcsb pdb:4FNC|rcsb pdb:4JGC|rcsb pdb:4XEG|rcsb pdb:4Z3A|rcsb pdb:4Z47|rcsb pdb:4Z7B|rcsb pdb:4Z7Z|rcsb pdb:5CYS|rcsb pdb:5FF8|rcsb pdb:5HF7|rcsb pdb:5JXY|rcsb pdb:5T2W|rcsb pdb:6U15|rcsb pdb:6U16|rcsb pdb:6U17|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110357|reactome:R-HSA-3108214|reactome:R-HSA-5221030|refseq:NP_003202.3|dip:DIP-32709N	psi-mi:"MI:0465"(dip)	comment:mint|function:Enhances steroid receptor-mediated transcriptional activation as well as activating basal transcription	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:sxkdS+nFno7SrUQ0BNj5sy+K9IE10116	rogid:LPhuo6buYUphV9aJ456Ydq36fnU9606	rigid:9Zpw4ls+zw56YPA311NlZWS1sp4	false	flag tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)