#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9VUQ5	uniprotkb:A1ZAW0	intact:EBI-442476|ensemblmetazoa:FBpp0075312|uniprotkb:Q2Q3Y0|uniprotkb:Q2Q3Y1|uniprotkb:Q2Q3Y3|uniprotkb:Q2Q3Y4|uniprotkb:Q2Q3Y5|uniprotkb:Q86P07|uniprotkb:C7LAD2|uniprotkb:Q8T3N2|uniprotkb:Q9VUQ6|intact:EBI-3430439	intact:EBI-84244|ensemblmetazoa:FBpp0086061|intact:EBI-2409754	psi-mi:ago2_drome(display_long)|uniprotkb:AGO2(gene name)|psi-mi:AGO2(display_short)|uniprotkb:CG7439(orf name)	psi-mi:a1zaw0_drome(display_long)|uniprotkb:Dcr-2(gene name)|psi-mi:Dcr-2(display_short)|uniprotkb:Dcr-2-RA(gene name synonym)|uniprotkb:DCR-2(gene name synonym)|uniprotkb:DCR2(gene name synonym)|uniprotkb:DICER(gene name synonym)|uniprotkb:Dcr(gene name synonym)|uniprotkb:Dcr2(gene name synonym)|uniprotkb:Dicer(gene name synonym)|uniprotkb:Dicer2(gene name synonym)|uniprotkb:Dmel\CG6493(gene name synonym)|uniprotkb:cg6493(gene name synonym)|uniprotkb:dDcr2(gene name synonym)|uniprotkb:dcr(gene name synonym)|uniprotkb:dcr-2(gene name synonym)|uniprotkb:dcr2(gene name synonym)|uniprotkb:dic2(gene name synonym)|uniprotkb:dicer(gene name synonym)|uniprotkb:dicer-2(gene name synonym)|uniprotkb:dicer2(gene name synonym)|uniprotkb:dmDcr-2(gene name synonym)|uniprotkb:CG6493(orf name)|uniprotkb:Dmel_CG6493(orf name)|uniprotkb:DICER-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Miyoshi et al. (2010)	pubmed:20639883|doi:10.1038/nsmb.1875|imex:IM-15993	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15866370|imex:IM-15993-1|dip:DIP-186570E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0087035(gene)|ensemblmetazoa:FBtr0075559(transcript)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007279"(pole cell formation)|go:"GO:0007349"(cellularization)|go:"GO:0007367"(segment polarity determination)|go:"GO:0009047"(dosage compensation by hyperactivation of X chromosome)|go:"GO:0009616"(RNAi-mediated antiviral immune response)|go:"GO:0010526"(negative regulation of transposition, RNA-mediated)|go:"GO:0016246"(RNA interference)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0033227"(dsRNA transport)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035190"(syncytial nuclear migration)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:0070922"(small RNA loading onto RISC)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q9VUQ5|rcsb pdb:1R6Z|rcsb pdb:1T2R|rcsb pdb:1T2S|rcsb pdb:1VYN|rcsb pdb:3MJ0|reactome:R-DME-203927|reactome:R-DME-426486|reactome:R-DME-426496|go:"GO:0035197"(siRNA binding)|refseq:NP_648775.1|refseq:NP_730054.1|flybase:FBgn0087035|dip:DIP-41570N	refseq:NP_523778.2|flybase:FBgn0034246|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006342"|go:"GO:0007626"(locomotory behavior)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0009047"(dosage compensation by hyperactivation of X chromosome)|go:"GO:0009597"(detection of virus)|go:"GO:0016246"(RNA interference)|go:"GO:0016442"(RISC complex)|go:"GO:0016443"(bidentate ribonuclease III activity)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0033227"(dsRNA transport)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035197"(siRNA binding)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045752"(positive regulation of Toll signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:0070922"(small RNA loading onto RISC)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|ensemblmetazoa:FBgn0034246(gene)|ensemblmetazoa:FBtr0086904(transcript)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036389|interpro:IPR038248|rcsb pdb:6BU9|rcsb pdb:6BUA|dip:DIP-54444N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/06	2017/08/10	rogid:Y3Jc/eqc+QUJupZ169PcsPduqro7227	rogid:Ti1bBqs1sFBecB2FZwqHM2VcSRY7227	rigid:zotdu8D/12Og2jnQxcnNoG2hZxw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9VUQ5	uniprotkb:Q9VLW8	intact:EBI-442476|ensemblmetazoa:FBpp0075312|uniprotkb:Q2Q3Y0|uniprotkb:Q2Q3Y1|uniprotkb:Q2Q3Y3|uniprotkb:Q2Q3Y4|uniprotkb:Q2Q3Y5|uniprotkb:Q86P07|uniprotkb:C7LAD2|uniprotkb:Q8T3N2|uniprotkb:Q9VUQ6|intact:EBI-3430439	intact:EBI-156415|ensemblmetazoa:FBpp0079112|ensemblmetazoa:FBpp0290544|ensemblmetazoa:FBpp0310061	psi-mi:ago2_drome(display_long)|uniprotkb:AGO2(gene name)|psi-mi:AGO2(display_short)|uniprotkb:CG7439(orf name)	psi-mi:q9vlw8_drome(display_long)|uniprotkb:r2d2(gene name)|psi-mi:r2d2(display_short)|uniprotkb:Dmel\CG7138(gene name synonym)|uniprotkb:R2D2(gene name synonym)|uniprotkb:R2d2(gene name synonym)|uniprotkb:cg7138(gene name synonym)|uniprotkb:CG7138(orf name)|uniprotkb:Dmel_CG7138(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Miyoshi et al. (2010)	pubmed:20639883|doi:10.1038/nsmb.1875|imex:IM-15993	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15866370|imex:IM-15993-1|dip:DIP-186570E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0087035(gene)|ensemblmetazoa:FBtr0075559(transcript)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007279"(pole cell formation)|go:"GO:0007349"(cellularization)|go:"GO:0007367"(segment polarity determination)|go:"GO:0009047"(dosage compensation by hyperactivation of X chromosome)|go:"GO:0009616"(RNAi-mediated antiviral immune response)|go:"GO:0010526"(negative regulation of transposition, RNA-mediated)|go:"GO:0016246"(RNA interference)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0033227"(dsRNA transport)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035190"(syncytial nuclear migration)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:0070922"(small RNA loading onto RISC)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q9VUQ5|rcsb pdb:1R6Z|rcsb pdb:1T2R|rcsb pdb:1T2S|rcsb pdb:1VYN|rcsb pdb:3MJ0|reactome:R-DME-203927|reactome:R-DME-426486|reactome:R-DME-426496|go:"GO:0035197"(siRNA binding)|refseq:NP_648775.1|refseq:NP_730054.1|flybase:FBgn0087035|dip:DIP-41570N	refseq:NP_001162903.1|refseq:NP_609152.1|flybase:FBgn0031951|refseq:NP_001285720.1|dip:DIP-34805N|ensemblmetazoa:FBgn0031951(gene)|ensemblmetazoa:FBtr0079489(transcript)|ensemblmetazoa:FBtr0301329(transcript)|ensemblmetazoa:FBtr0343415(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030713"(ovarian follicle cell stalk formation)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035197"(siRNA binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:0070918"(primary sncRNA processing)|go:"GO:0070920"(regulation of production of small RNA involved in gene silencing by RNA)|interpro:IPR014720(Double-stranded RNA-binding-like)|reactome:R-DME-203927|reactome:R-DME-426486	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/06	2017/08/10	rogid:Y3Jc/eqc+QUJupZ169PcsPduqro7227	rogid:xnR+vKJN0j+r0G/bo3UdrnNAjIU7227	rigid:zotdu8D/12Og2jnQxcnNoG2hZxw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P02828	uniprotkb:Q9VUQ5	intact:EBI-136814|ensemblmetazoa:FBpp0072904|ensemblmetazoa:FBpp0305095|uniprotkb:P92174|uniprotkb:P92202|uniprotkb:Q9VZT3	intact:EBI-442476|ensemblmetazoa:FBpp0075312|uniprotkb:Q2Q3Y0|uniprotkb:Q2Q3Y1|uniprotkb:Q2Q3Y3|uniprotkb:Q2Q3Y4|uniprotkb:Q2Q3Y5|uniprotkb:Q86P07|uniprotkb:C7LAD2|uniprotkb:Q8T3N2|uniprotkb:Q9VUQ6|intact:EBI-3430439	psi-mi:hsp83_drome(display_long)|uniprotkb:Hsp83(gene name)|psi-mi:Hsp83(display_short)|uniprotkb:Hsp82(gene name synonym)|uniprotkb:HSP 82(gene name synonym)|uniprotkb:Hsp90(gene name synonym)|uniprotkb:CG1242(orf name)	psi-mi:ago2_drome(display_long)|uniprotkb:AGO2(gene name)|psi-mi:AGO2(display_short)|uniprotkb:CG7439(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Miyoshi et al. (2010)	pubmed:20639883|doi:10.1038/nsmb.1875|imex:IM-15993	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15866390|imex:IM-15993-2|dip:DIP-186571E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005158"(insulin receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005705"(polytene chromosome interband)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|ensemblmetazoa:FBgn0001233(gene)|ensemblmetazoa:FBtr0073040(transcript)|ensemblmetazoa:FBtr0332873(transcript)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0009631"(cold acclimation)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0019094"(pole plasm mRNA localization)|go:"GO:0030911"(TPR domain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0101031"(chaperone complex)|go:"GO:0106161"(obsolete positive regulation of small RNA loading onto RISC)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|reactome:R-DME-1227986|reactome:R-DME-1474151|reactome:R-DME-2029482|reactome:R-DME-203615|reactome:R-DME-3371497|reactome:R-DME-3371511|refseq:NP_523899.1|flybase:FBgn0001233|refseq:NP_001261362.1|go:"GO:0043248"(proteasome assembly)|dip:DIP-17366N|reactome:R-DME-399954|reactome:R-DME-5218920|reactome:R-DME-5675482|reactome:R-DME-6798695|reactome:R-DME-3371571|reactome:R-DME-8863795|reactome:R-DME-8937144|reactome:R-DME-8939211|reactome:R-DME-9009391|reactome:R-DME-9013418|reactome:R-DME-9652282	ensemblmetazoa:FBgn0087035(gene)|ensemblmetazoa:FBtr0075559(transcript)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007279"(pole cell formation)|go:"GO:0007349"(cellularization)|go:"GO:0007367"(segment polarity determination)|go:"GO:0009047"(dosage compensation by hyperactivation of X chromosome)|go:"GO:0009616"(RNAi-mediated antiviral immune response)|go:"GO:0010526"(negative regulation of transposition, RNA-mediated)|go:"GO:0016246"(RNA interference)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0033227"(dsRNA transport)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035190"(syncytial nuclear migration)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:0070922"(small RNA loading onto RISC)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q9VUQ5|rcsb pdb:1R6Z|rcsb pdb:1T2R|rcsb pdb:1T2S|rcsb pdb:1VYN|rcsb pdb:3MJ0|reactome:R-DME-203927|reactome:R-DME-426486|reactome:R-DME-426496|go:"GO:0035197"(siRNA binding)|refseq:NP_648775.1|refseq:NP_730054.1|flybase:FBgn0087035|dip:DIP-41570N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/06	2017/08/10	rogid:PS2fd2RD7YWygzaMqF40SNCb2xQ7227	rogid:Y3Jc/eqc+QUJupZ169PcsPduqro7227	rigid:aibA0o2otKNrobC0CWrmYoSjuSk	false	-	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)