#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P16474	uniprotkb:P32361	intact:EBI-7876|ensemblfungi:YJL034W|uniprotkb:D6VWE9	intact:EBI-9364|ensemblfungi:YHR079C|uniprotkb:D3DL29	psi-mi:bip_yeast(display_long)|uniprotkb:KAR2(gene name)|psi-mi:KAR2(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:SSD1(gene name synonym)|uniprotkb:YJL034W(locus name)|uniprotkb:J1248(orf name)|uniprotkb:Immunoglobulin heavy chain-binding protein homolog(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein homolog(gene name synonym)	psi-mi:ire1_yeast(display_long)|uniprotkb:IRE1(gene name)|psi-mi:IRE1(display_short)|uniprotkb:ERN1(gene name synonym)|uniprotkb:YHR079C(locus name)|uniprotkb:Endoplasmic reticulum-to-nucleus signaling 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pincus et al. (2010)	pubmed:20625545|doi:10.1371/journal.pbio.1000415|imex:IM-15872	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15865440|imex:IM-15872-1|dip:DIP-186207E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003571|ensemblfungi:YJL034W(gene)|ensemblfungi:YJL034W_mRNA(transcript)|go:"GO:0000742"(karyogamy involved in conjugation with cellular fusion)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|refseq:NP_012500.3|mint:P16474|dip:DIP-2392N|rcsb pdb:3QFP|rcsb pdb:3QFU|rcsb pdb:3QML|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0034099"(luminal surveillance complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0070880"(fungal-type cell wall beta-glucan biosynthetic process)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|rcsb pdb:3H0X	ensemblfungi:YHR079C(gene)|ensemblfungi:YHR079C_mRNA(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036290"(protein trans-autophosphorylation)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR010513(Ribonuclease L)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018391|interpro:IPR038357|rcsb pdb:2BE1|rcsb pdb:2RIO|rcsb pdb:3FBV|rcsb pdb:3LJ0|rcsb pdb:3LJ1|rcsb pdb:3LJ2|rcsb pdb:3SDJ|rcsb pdb:3SDM|reactome:R-SCE-381070|refseq:NP_011946.1|sgd:S000001121|mint:P32361|dip:DIP-233N	psi-mi:"MI:0465"(dip)	crc64:A107BD03DF3F30D3	crc64:BD65D74E74365945	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/06	2017/08/10	rogid:+zA2eFylZ+4FgQ5zac8xx/GRV7g559292	rogid:5j7Ysqx11W9m7L8UESE8Q7YeDyw559292	rigid:iHqg0EyOemIqBhvt2TPVTv96q30	false	-	ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32361	uniprotkb:P32361	intact:EBI-9364|ensemblfungi:YHR079C|uniprotkb:D3DL29	intact:EBI-9364|ensemblfungi:YHR079C|uniprotkb:D3DL29	psi-mi:ire1_yeast(display_long)|uniprotkb:IRE1(gene name)|psi-mi:IRE1(display_short)|uniprotkb:ERN1(gene name synonym)|uniprotkb:YHR079C(locus name)|uniprotkb:Endoplasmic reticulum-to-nucleus signaling 1(gene name synonym)	psi-mi:ire1_yeast(display_long)|uniprotkb:IRE1(gene name)|psi-mi:IRE1(display_short)|uniprotkb:ERN1(gene name synonym)|uniprotkb:YHR079C(locus name)|uniprotkb:Endoplasmic reticulum-to-nucleus signaling 1(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Pincus et al. (2010)	pubmed:20625545|doi:10.1371/journal.pbio.1000415|imex:IM-15872	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0465"(DIP)	intact:EBI-15865459|imex:IM-15872-2|dip:DIP-68311E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YHR079C(gene)|ensemblfungi:YHR079C_mRNA(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036290"(protein trans-autophosphorylation)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR010513(Ribonuclease L)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018391|interpro:IPR038357|rcsb pdb:2BE1|rcsb pdb:2RIO|rcsb pdb:3FBV|rcsb pdb:3LJ0|rcsb pdb:3LJ1|rcsb pdb:3LJ2|rcsb pdb:3SDJ|rcsb pdb:3SDM|reactome:R-SCE-381070|refseq:NP_011946.1|sgd:S000001121|mint:P32361|dip:DIP-233N	ensemblfungi:YHR079C(gene)|ensemblfungi:YHR079C_mRNA(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036290"(protein trans-autophosphorylation)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR010513(Ribonuclease L)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018391|interpro:IPR038357|rcsb pdb:2BE1|rcsb pdb:2RIO|rcsb pdb:3FBV|rcsb pdb:3LJ0|rcsb pdb:3LJ1|rcsb pdb:3LJ2|rcsb pdb:3SDJ|rcsb pdb:3SDM|reactome:R-SCE-381070|refseq:NP_011946.1|sgd:S000001121|mint:P32361|dip:DIP-233N	psi-mi:"MI:0465"(dip)	crc64:BD65D74E74365945	crc64:BD65D74E74365945	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/06	2017/08/10	rogid:5j7Ysqx11W9m7L8UESE8Q7YeDyw559292	rogid:5j7Ysqx11W9m7L8UESE8Q7YeDyw559292	rigid:PIk7OrLcgKxGyVWLMJp9BICByCI	false	fluorescent protein tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)