#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9UPP1 intact:EBI-15634422 intact:EBI-1560800|uniprotkb:Q5H9U5|uniprotkb:Q5VUJ4|uniprotkb:Q7Z6D4|uniprotkb:Q9HAH2|uniprotkb:Q5JPS0|uniprotkb:Q5JPS2|uniprotkb:Q5JPS3|uniprotkb:B7Z911|uniprotkb:Q5JPR9|uniprotkb:B3KMV4|ensembl:ENSP00000350676 dip:DIP-29329N psi-mi:phf8_human(display_long)|uniprotkb:PHF8(gene name)|psi-mi:PHF8(display_short)|uniprotkb:KIAA1111(gene name synonym)|uniprotkb:ZNF422(gene name synonym)|uniprotkb:PHD finger protein 8(gene name synonym)|uniprotkb:"[histone H3]-dimethyl-L-lysine(36) demethylase PHF8"(gene name synonym)|uniprotkb:"[histone H3]-dimethyl-L-lysine(9) demethylase PHF8"(gene name synonym) psi-mi:h3k9-2(display_short)|psi-mi:EBI-15634422(display_long) psi-mi:"MI:0096"(pull down) Liu et al. (2010) pubmed:20622854|doi:10.1038/nature09272|imex:IM-21508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15864747|imex:IM-21508-1|dip:DIP-191774E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) refseq:NP_001171825.1|refseq:NP_001171826.1|refseq:NP_055922.1|refseq:XP_016884851.1|dip:DIP-38913N|ensembl:ENSG00000172943(gene)|ensembl:ENST00000357988(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006482"(protein demethylation)|go:"GO:0007420"(brain development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035574"(histone H4-K20 demethylation)|go:"GO:0035575"(histone H4-methyl-lysine-20 demethylase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0061188"(negative regulation of ribosomal DNA heterochromatin assembly)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR041070|rcsb pdb:2WWU|rcsb pdb:3K3N|rcsb pdb:3K3O|rcsb pdb:3KV4|rcsb pdb:4DO0|rcsb pdb:7CMZ|reactome:R-HSA-2299718|reactome:R-HSA-3214842 - psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:/HpV11qoBcuj2YCa2dQWuo9moCk9606 rogid:6M86IQcphd/YS8g0BNmUqxkx7Bk-2 rigid:VYPwabV18k7HmTDNws3RrOZhNJo false - N6,N6-dimethyl-L-lysine:4-4|N6,N6,N6-trimethyl-L-lysine:4-4|biotin tag:0-0 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UPP1 uniprotkb:Q01094 intact:EBI-1560800|uniprotkb:Q5H9U5|uniprotkb:Q5VUJ4|uniprotkb:Q7Z6D4|uniprotkb:Q9HAH2|uniprotkb:Q5JPS0|uniprotkb:Q5JPS2|uniprotkb:Q5JPS3|uniprotkb:B7Z911|uniprotkb:Q5JPR9|uniprotkb:B3KMV4|ensembl:ENSP00000350676 intact:EBI-448924|uniprotkb:Q13143|uniprotkb:Q92768|ensembl:ENSP00000345571 psi-mi:phf8_human(display_long)|uniprotkb:PHF8(gene name)|psi-mi:PHF8(display_short)|uniprotkb:KIAA1111(gene name synonym)|uniprotkb:ZNF422(gene name synonym)|uniprotkb:PHD finger protein 8(gene name synonym)|uniprotkb:"[histone H3]-dimethyl-L-lysine(36) demethylase PHF8"(gene name synonym)|uniprotkb:"[histone H3]-dimethyl-L-lysine(9) demethylase PHF8"(gene name synonym) psi-mi:e2f1_human(display_long)|uniprotkb:Retinoblastoma-associated protein 1(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 3(gene name synonym)|uniprotkb:PBR3(gene name synonym)|uniprotkb:E2F1(gene name)|psi-mi:E2F1(display_short)|uniprotkb:RBBP3(gene name synonym)|uniprotkb:pRB-binding protein E2F-1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Liu et al. (2010) pubmed:20622854|doi:10.1038/nature09272|imex:IM-21508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15864821|imex:IM-21508-4|dip:DIP-191775E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001171825.1|refseq:NP_001171826.1|refseq:NP_055922.1|refseq:XP_016884851.1|dip:DIP-38913N|ensembl:ENSG00000172943(gene)|ensembl:ENST00000357988(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006482"(protein demethylation)|go:"GO:0007420"(brain development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035574"(histone H4-K20 demethylation)|go:"GO:0035575"(histone H4-methyl-lysine-20 demethylase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0061188"(negative regulation of ribosomal DNA heterochromatin assembly)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR041070|rcsb pdb:2WWU|rcsb pdb:3K3N|rcsb pdb:3K3O|rcsb pdb:3KV4|rcsb pdb:4DO0|rcsb pdb:7CMZ|reactome:R-HSA-2299718|reactome:R-HSA-3214842 refseq:NP_005216.1|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048255"(mRNA stabilization)|ensembl:ENSG00000101412(gene)|ensembl:ENST00000343380(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-6804116|reactome:R-HSA-68689|reactome:R-HSA-68911|reactome:R-HSA-69202|reactome:R-HSA-69205|reactome:R-HSA-69231|interpro:IPR032198|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|mint:Q01094|rcsb pdb:1H24|rcsb pdb:1O9K|rcsb pdb:2AZE|rcsb pdb:5M9N|rcsb pdb:5M9O|rcsb pdb:6G0P|rcsb pdb:6ULS|reactome:R-HSA-111448|reactome:R-HSA-113501|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-69656|reactome:R-HSA-8953750|reactome:R-HSA-9616222|reactome:R-HSA-9661069|dip:DIP-24227N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:/HpV11qoBcuj2YCa2dQWuo9moCk9606 rogid:vPNenpmxyXpHjMzUID54cwMFk+Y9606 rigid:DwnFUYqdB6zgSAJI5oizn/h4Xn4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UPP1 uniprotkb:O15047 intact:EBI-1560800|uniprotkb:Q5H9U5|uniprotkb:Q5VUJ4|uniprotkb:Q7Z6D4|uniprotkb:Q9HAH2|uniprotkb:Q5JPS0|uniprotkb:Q5JPS2|uniprotkb:Q5JPS3|uniprotkb:B7Z911|uniprotkb:Q5JPR9|uniprotkb:B3KMV4|ensembl:ENSP00000350676 intact:EBI-540779|uniprotkb:A6NP62|uniprotkb:Q6PIF3|uniprotkb:Q8TAJ6|intact:EBI-28969638|ensembl:ENSP00000262519|ensembl:ENSP00000507683 psi-mi:phf8_human(display_long)|uniprotkb:PHF8(gene name)|psi-mi:PHF8(display_short)|uniprotkb:KIAA1111(gene name synonym)|uniprotkb:ZNF422(gene name synonym)|uniprotkb:PHD finger protein 8(gene name synonym)|uniprotkb:"[histone H3]-dimethyl-L-lysine(36) demethylase PHF8"(gene name synonym)|uniprotkb:"[histone H3]-dimethyl-L-lysine(9) demethylase PHF8"(gene name synonym) psi-mi:set1a_human(display_long)|uniprotkb:KMT2F(gene name synonym)|uniprotkb:SET domain-containing protein 1A(gene name synonym)|uniprotkb:Set1/Ash2 histone methyltransferase complex subunit SET1(gene name synonym)|uniprotkb:Lysine N-methyltransferase 2F(gene name synonym)|uniprotkb:SETD1A(gene name)|psi-mi:SETD1A(display_short)|uniprotkb:KIAA0339(gene name synonym)|uniprotkb:SET1(gene name synonym)|uniprotkb:SET1A(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Liu et al. (2010) pubmed:20622854|doi:10.1038/nature09272|imex:IM-21508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15864821|imex:IM-21508-4|dip:DIP-191775E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001171825.1|refseq:NP_001171826.1|refseq:NP_055922.1|refseq:XP_016884851.1|dip:DIP-38913N|ensembl:ENSG00000172943(gene)|ensembl:ENST00000357988(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006482"(protein demethylation)|go:"GO:0007420"(brain development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035574"(histone H4-K20 demethylation)|go:"GO:0035575"(histone H4-methyl-lysine-20 demethylase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0061188"(negative regulation of ribosomal DNA heterochromatin assembly)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR041070|rcsb pdb:2WWU|rcsb pdb:3K3N|rcsb pdb:3K3O|rcsb pdb:3KV4|rcsb pdb:4DO0|rcsb pdb:7CMZ|reactome:R-HSA-2299718|reactome:R-HSA-3214842 refseq:NP_055527.1|refseq:XP_006721169.1|ensembl:ENSP00000262519|ensembl:ENSP00000507683|reactome:R-HSA-8936459|reactome:R-HSA-3214841|ensembl:ENSG00000099381(gene)|ensembl:ENST00000262519(transcript)|ensembl:ENST00000684162(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007420"(brain development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001214(SET)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR024657|interpro:IPR034467|interpro:IPR035979|interpro:IPR037841|interpro:IPR044570|mint:O15047|go:"GO:0048188"(Set1C/COMPASS complex)|rcsb pdb:3S8S|rcsb pdb:3UVN|rcsb pdb:4EWR|refseq:XP_005255780.1|refseq:XP_016879398.1|dip:DIP-33494N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:/HpV11qoBcuj2YCa2dQWuo9moCk9606 rogid:nx0uWEVFas1w2NmuG73lCObAULE9606 rigid:DwnFUYqdB6zgSAJI5oizn/h4Xn4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UPP1 uniprotkb:P51610-1 intact:EBI-1560800|uniprotkb:Q5H9U5|uniprotkb:Q5VUJ4|uniprotkb:Q7Z6D4|uniprotkb:Q9HAH2|uniprotkb:Q5JPS0|uniprotkb:Q5JPS2|uniprotkb:Q5JPS3|uniprotkb:B7Z911|uniprotkb:Q5JPR9|uniprotkb:B3KMV4|ensembl:ENSP00000350676 intact:EBI-396188|ensembl:ENSP00000309555 psi-mi:phf8_human(display_long)|uniprotkb:PHF8(gene name)|psi-mi:PHF8(display_short)|uniprotkb:KIAA1111(gene name synonym)|uniprotkb:ZNF422(gene name synonym)|uniprotkb:PHD finger protein 8(gene name synonym)|uniprotkb:"[histone H3]-dimethyl-L-lysine(36) demethylase PHF8"(gene name synonym)|uniprotkb:"[histone H3]-dimethyl-L-lysine(9) demethylase PHF8"(gene name synonym) psi-mi:p51610-1(display_long)|uniprotkb:HCFC1(gene name)|psi-mi:HCFC1(display_short)|uniprotkb:HCF1(gene name synonym)|uniprotkb:HFC1(gene name synonym)|uniprotkb:C1 factor(gene name synonym)|uniprotkb:CFF(gene name synonym)|uniprotkb:VCAF(gene name synonym)|uniprotkb:VP16 accessory protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Liu et al. (2010) pubmed:20622854|doi:10.1038/nature09272|imex:IM-21508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15864821|imex:IM-21508-4|dip:DIP-191775E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001171825.1|refseq:NP_001171826.1|refseq:NP_055922.1|refseq:XP_016884851.1|dip:DIP-38913N|ensembl:ENSG00000172943(gene)|ensembl:ENST00000357988(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006482"(protein demethylation)|go:"GO:0007420"(brain development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035574"(histone H4-K20 demethylation)|go:"GO:0035575"(histone H4-methyl-lysine-20 demethylase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0061188"(negative regulation of ribosomal DNA heterochromatin assembly)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR041070|rcsb pdb:2WWU|rcsb pdb:3K3N|rcsb pdb:3K3O|rcsb pdb:3KV4|rcsb pdb:4DO0|rcsb pdb:7CMZ|reactome:R-HSA-2299718|reactome:R-HSA-3214842 intact:EBI-396176(hcfc1_human)|ensembl:ENSG00000172534(gene)|ensembl:ENST00000310441(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:/HpV11qoBcuj2YCa2dQWuo9moCk9606 rogid:RzsCRe9l6md3DI87H4ZgdR9oBMI9606 rigid:DwnFUYqdB6zgSAJI5oizn/h4Xn4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42695 intact:EBI-15863530 intact:EBI-722805|uniprotkb:A6NFS2|uniprotkb:Q4KMQ9|ensembl:ENSP00000433681 dip:DIP-59246N psi-mi:cndd3_human(display_long)|uniprotkb:Non-SMC condensin II complex subunit D3(gene name synonym)|uniprotkb:NCAPD3(gene name)|psi-mi:NCAPD3(display_short)|uniprotkb:CAPD3(gene name synonym)|uniprotkb:KIAA0056(gene name synonym) psi-mi:h4-2(display_short)|psi-mi:EBI-15863530(display_long) psi-mi:"MI:0096"(pull down) Liu et al. (2010) pubmed:20622854|doi:10.1038/nature09272|imex:IM-21508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15864794|imex:IM-21508-3|dip:DIP-191779E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) refseq:NP_056076.1|dip:DIP-43903N|ensembl:ENSG00000151503(gene)|ensembl:ENST00000534548(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0016020"(membrane)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042393"(histone binding)|go:"GO:0051301"(cell division)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012371(Chromosome condensation protein, HCP-6-related)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026971|interpro:IPR032682|mint:P42695|reactome:R-HSA-2299718 - psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:z5WYLlrGt33uAM9NRN9SQeHFDaA9606 rogid:70QToOgC0sUyRRzZsRe6yR/8LzQ-2 rigid:DKbcEItBh1WcVevfFHDGElUZ2yk false sufficient binding region:433-665|sufficient binding region:892-1062|his tag:n-n N6-methyl-L-lysine:20-20|biotin tag:0-0 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P51610-1 uniprotkb:Q9UPP1-2 intact:EBI-396188|ensembl:ENSP00000309555 intact:EBI-6601215|ensembl:ENSP00000338868 psi-mi:p51610-1(display_long)|uniprotkb:HCFC1(gene name)|psi-mi:HCFC1(display_short)|uniprotkb:HCF1(gene name synonym)|uniprotkb:HFC1(gene name synonym)|uniprotkb:C1 factor(gene name synonym)|uniprotkb:CFF(gene name synonym)|uniprotkb:VCAF(gene name synonym)|uniprotkb:VP16 accessory protein(gene name synonym) psi-mi:q9upp1-2(display_long)|uniprotkb:PHF8(gene name)|psi-mi:PHF8(display_short)|uniprotkb:KIAA1111(gene name synonym)|uniprotkb:ZNF422(gene name synonym)|uniprotkb:PHD finger protein 8(gene name synonym)|uniprotkb:"[histone H3]-dimethyl-L-lysine(36) demethylase PHF8"(gene name synonym)|uniprotkb:"[histone H3]-dimethyl-L-lysine(9) demethylase PHF8"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Liu et al. (2010) pubmed:20622854|doi:10.1038/nature09272|imex:IM-21508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15864770|imex:IM-21508-2|dip:DIP-191776E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-396176(hcfc1_human)|ensembl:ENSG00000172534(gene)|ensembl:ENST00000310441(transcript) intact:EBI-1560800(isoform-parent)|uniprotkb:Q9UPP1-2(isoform-parent)|ensembl:ENSG00000172943(gene)|ensembl:ENST00000338154(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/14 rogid:RzsCRe9l6md3DI87H4ZgdR9oBMI9606 rogid:VFLb8SCdO/CUJylDbK3j+LN/6aE9606 rigid:K3ZwPcSW0mnu1By1M9IPwHJu98A false ha tag:n-n|sufficient binding region:2-1011 flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q86XI2-1 intact:EBI-15863530 intact:EBI-15864840|ensembl:ENSP00000348657|ensembl:ENSP00000386569 dip:DIP-59246N psi-mi:q86xi2-1(display_long)|uniprotkb:Chromosome-associated protein G2(gene name synonym)|uniprotkb:Leucine zipper protein 5(gene name synonym)|uniprotkb:Non-SMC condensin II complex subunit G2(gene name synonym)|uniprotkb:NCAPG2(gene name)|psi-mi:NCAPG2(display_short)|uniprotkb:LUZP5(gene name synonym) psi-mi:h4-2(display_short)|psi-mi:EBI-15863530(display_long) psi-mi:"MI:0096"(pull down) Liu et al. (2010) pubmed:20622854|doi:10.1038/nature09272|imex:IM-21508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15864849|imex:IM-21508-5|dip:DIP-191780E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) ensembl:ENSG00000146918(gene)|ensembl:ENST00000356309(transcript)|ensembl:ENST00000409423(transcript)|intact:EBI-1047404(isoform-parent) - psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:4JkTPdyKz1cYblG0ZU0vQKMsuB49606 rogid:70QToOgC0sUyRRzZsRe6yR/8LzQ-2 rigid:79c+voRSko1lk9HQH7h3MHQk93o false his tag:n-n|sufficient binding region:319-547 N6-methyl-L-lysine:20-20|biotin tag:0-0 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q01094 uniprotkb:P51610-1 intact:EBI-448924|uniprotkb:Q13143|uniprotkb:Q92768|ensembl:ENSP00000345571 intact:EBI-396188|ensembl:ENSP00000309555 psi-mi:e2f1_human(display_long)|uniprotkb:Retinoblastoma-associated protein 1(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 3(gene name synonym)|uniprotkb:PBR3(gene name synonym)|uniprotkb:E2F1(gene name)|psi-mi:E2F1(display_short)|uniprotkb:RBBP3(gene name synonym)|uniprotkb:pRB-binding protein E2F-1(gene name synonym) psi-mi:p51610-1(display_long)|uniprotkb:HCFC1(gene name)|psi-mi:HCFC1(display_short)|uniprotkb:HCF1(gene name synonym)|uniprotkb:HFC1(gene name synonym)|uniprotkb:C1 factor(gene name synonym)|uniprotkb:CFF(gene name synonym)|uniprotkb:VCAF(gene name synonym)|uniprotkb:VP16 accessory protein(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Liu et al. (2010) pubmed:20622854|doi:10.1038/nature09272|imex:IM-21508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15864950|imex:IM-21508-9|dip:DIP-191775E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005216.1|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048255"(mRNA stabilization)|ensembl:ENSG00000101412(gene)|ensembl:ENST00000343380(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-6804116|reactome:R-HSA-68689|reactome:R-HSA-68911|reactome:R-HSA-69202|reactome:R-HSA-69205|reactome:R-HSA-69231|interpro:IPR032198|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|mint:Q01094|rcsb pdb:1H24|rcsb pdb:1O9K|rcsb pdb:2AZE|rcsb pdb:5M9N|rcsb pdb:5M9O|rcsb pdb:6G0P|rcsb pdb:6ULS|reactome:R-HSA-111448|reactome:R-HSA-113501|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-69656|reactome:R-HSA-8953750|reactome:R-HSA-9616222|reactome:R-HSA-9661069|dip:DIP-24227N intact:EBI-396176(hcfc1_human)|ensembl:ENSG00000172534(gene)|ensembl:ENST00000310441(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:vPNenpmxyXpHjMzUID54cwMFk+Y9606 rogid:RzsCRe9l6md3DI87H4ZgdR9oBMI9606 rigid:DwnFUYqdB6zgSAJI5oizn/h4Xn4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q01094 uniprotkb:Q9UPP1 intact:EBI-448924|uniprotkb:Q13143|uniprotkb:Q92768|ensembl:ENSP00000345571 intact:EBI-1560800|uniprotkb:Q5H9U5|uniprotkb:Q5VUJ4|uniprotkb:Q7Z6D4|uniprotkb:Q9HAH2|uniprotkb:Q5JPS0|uniprotkb:Q5JPS2|uniprotkb:Q5JPS3|uniprotkb:B7Z911|uniprotkb:Q5JPR9|uniprotkb:B3KMV4|ensembl:ENSP00000350676 psi-mi:e2f1_human(display_long)|uniprotkb:Retinoblastoma-associated protein 1(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 3(gene name synonym)|uniprotkb:PBR3(gene name synonym)|uniprotkb:E2F1(gene name)|psi-mi:E2F1(display_short)|uniprotkb:RBBP3(gene name synonym)|uniprotkb:pRB-binding protein E2F-1(gene name synonym) psi-mi:phf8_human(display_long)|uniprotkb:PHF8(gene name)|psi-mi:PHF8(display_short)|uniprotkb:KIAA1111(gene name synonym)|uniprotkb:ZNF422(gene name synonym)|uniprotkb:PHD finger protein 8(gene name synonym)|uniprotkb:"[histone H3]-dimethyl-L-lysine(36) demethylase PHF8"(gene name synonym)|uniprotkb:"[histone H3]-dimethyl-L-lysine(9) demethylase PHF8"(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Liu et al. (2010) pubmed:20622854|doi:10.1038/nature09272|imex:IM-21508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15864950|imex:IM-21508-9|dip:DIP-191775E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005216.1|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048255"(mRNA stabilization)|ensembl:ENSG00000101412(gene)|ensembl:ENST00000343380(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-6804116|reactome:R-HSA-68689|reactome:R-HSA-68911|reactome:R-HSA-69202|reactome:R-HSA-69205|reactome:R-HSA-69231|interpro:IPR032198|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|mint:Q01094|rcsb pdb:1H24|rcsb pdb:1O9K|rcsb pdb:2AZE|rcsb pdb:5M9N|rcsb pdb:5M9O|rcsb pdb:6G0P|rcsb pdb:6ULS|reactome:R-HSA-111448|reactome:R-HSA-113501|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-69656|reactome:R-HSA-8953750|reactome:R-HSA-9616222|reactome:R-HSA-9661069|dip:DIP-24227N refseq:NP_001171825.1|refseq:NP_001171826.1|refseq:NP_055922.1|refseq:XP_016884851.1|dip:DIP-38913N|ensembl:ENSG00000172943(gene)|ensembl:ENST00000357988(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006482"(protein demethylation)|go:"GO:0007420"(brain development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035574"(histone H4-K20 demethylation)|go:"GO:0035575"(histone H4-methyl-lysine-20 demethylase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0061188"(negative regulation of ribosomal DNA heterochromatin assembly)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR041070|rcsb pdb:2WWU|rcsb pdb:3K3N|rcsb pdb:3K3O|rcsb pdb:3KV4|rcsb pdb:4DO0|rcsb pdb:7CMZ|reactome:R-HSA-2299718|reactome:R-HSA-3214842 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:vPNenpmxyXpHjMzUID54cwMFk+Y9606 rogid:/HpV11qoBcuj2YCa2dQWuo9moCk9606 rigid:DwnFUYqdB6zgSAJI5oizn/h4Xn4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q01094 uniprotkb:O15047 intact:EBI-448924|uniprotkb:Q13143|uniprotkb:Q92768|ensembl:ENSP00000345571 intact:EBI-540779|uniprotkb:A6NP62|uniprotkb:Q6PIF3|uniprotkb:Q8TAJ6|intact:EBI-28969638|ensembl:ENSP00000262519|ensembl:ENSP00000507683 psi-mi:e2f1_human(display_long)|uniprotkb:Retinoblastoma-associated protein 1(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 3(gene name synonym)|uniprotkb:PBR3(gene name synonym)|uniprotkb:E2F1(gene name)|psi-mi:E2F1(display_short)|uniprotkb:RBBP3(gene name synonym)|uniprotkb:pRB-binding protein E2F-1(gene name synonym) psi-mi:set1a_human(display_long)|uniprotkb:KMT2F(gene name synonym)|uniprotkb:SET domain-containing protein 1A(gene name synonym)|uniprotkb:Set1/Ash2 histone methyltransferase complex subunit SET1(gene name synonym)|uniprotkb:Lysine N-methyltransferase 2F(gene name synonym)|uniprotkb:SETD1A(gene name)|psi-mi:SETD1A(display_short)|uniprotkb:KIAA0339(gene name synonym)|uniprotkb:SET1(gene name synonym)|uniprotkb:SET1A(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Liu et al. (2010) pubmed:20622854|doi:10.1038/nature09272|imex:IM-21508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15864950|imex:IM-21508-9|dip:DIP-191775E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005216.1|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048255"(mRNA stabilization)|ensembl:ENSG00000101412(gene)|ensembl:ENST00000343380(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-6804116|reactome:R-HSA-68689|reactome:R-HSA-68911|reactome:R-HSA-69202|reactome:R-HSA-69205|reactome:R-HSA-69231|interpro:IPR032198|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|mint:Q01094|rcsb pdb:1H24|rcsb pdb:1O9K|rcsb pdb:2AZE|rcsb pdb:5M9N|rcsb pdb:5M9O|rcsb pdb:6G0P|rcsb pdb:6ULS|reactome:R-HSA-111448|reactome:R-HSA-113501|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-69656|reactome:R-HSA-8953750|reactome:R-HSA-9616222|reactome:R-HSA-9661069|dip:DIP-24227N refseq:NP_055527.1|refseq:XP_006721169.1|ensembl:ENSP00000262519|ensembl:ENSP00000507683|reactome:R-HSA-8936459|reactome:R-HSA-3214841|ensembl:ENSG00000099381(gene)|ensembl:ENST00000262519(transcript)|ensembl:ENST00000684162(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007420"(brain development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001214(SET)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR024657|interpro:IPR034467|interpro:IPR035979|interpro:IPR037841|interpro:IPR044570|mint:O15047|go:"GO:0048188"(Set1C/COMPASS complex)|rcsb pdb:3S8S|rcsb pdb:3UVN|rcsb pdb:4EWR|refseq:XP_005255780.1|refseq:XP_016879398.1|dip:DIP-33494N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:vPNenpmxyXpHjMzUID54cwMFk+Y9606 rogid:nx0uWEVFas1w2NmuG73lCObAULE9606 rigid:DwnFUYqdB6zgSAJI5oizn/h4Xn4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P51610-1 uniprotkb:Q9UPP1-2 intact:EBI-396188|ensembl:ENSP00000309555 intact:EBI-6601215|ensembl:ENSP00000338868 psi-mi:p51610-1(display_long)|uniprotkb:HCFC1(gene name)|psi-mi:HCFC1(display_short)|uniprotkb:HCF1(gene name synonym)|uniprotkb:HFC1(gene name synonym)|uniprotkb:C1 factor(gene name synonym)|uniprotkb:CFF(gene name synonym)|uniprotkb:VCAF(gene name synonym)|uniprotkb:VP16 accessory protein(gene name synonym) psi-mi:q9upp1-2(display_long)|uniprotkb:PHF8(gene name)|psi-mi:PHF8(display_short)|uniprotkb:KIAA1111(gene name synonym)|uniprotkb:ZNF422(gene name synonym)|uniprotkb:PHD finger protein 8(gene name synonym)|uniprotkb:"[histone H3]-dimethyl-L-lysine(36) demethylase PHF8"(gene name synonym)|uniprotkb:"[histone H3]-dimethyl-L-lysine(9) demethylase PHF8"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Liu et al. (2010) pubmed:20622854|doi:10.1038/nature09272|imex:IM-21508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15864928|imex:IM-21508-8|dip:DIP-191776E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-396176(hcfc1_human)|ensembl:ENSG00000172534(gene)|ensembl:ENST00000310441(transcript) intact:EBI-1560800(isoform-parent)|uniprotkb:Q9UPP1-2(isoform-parent)|ensembl:ENSG00000172943(gene)|ensembl:ENST00000338154(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/14 rogid:RzsCRe9l6md3DI87H4ZgdR9oBMI9606 rogid:VFLb8SCdO/CUJylDbK3j+LN/6aE9606 rigid:K3ZwPcSW0mnu1By1M9IPwHJu98A false green fluorescent protein tag:n-n flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UPP1-2 intact:EBI-15634422 intact:EBI-6601215|ensembl:ENSP00000338868 dip:DIP-29329N psi-mi:q9upp1-2(display_long)|uniprotkb:PHF8(gene name)|psi-mi:PHF8(display_short)|uniprotkb:KIAA1111(gene name synonym)|uniprotkb:ZNF422(gene name synonym)|uniprotkb:PHD finger protein 8(gene name synonym)|uniprotkb:"[histone H3]-dimethyl-L-lysine(36) demethylase PHF8"(gene name synonym)|uniprotkb:"[histone H3]-dimethyl-L-lysine(9) demethylase PHF8"(gene name synonym) psi-mi:h3k9-2(display_short)|psi-mi:EBI-15634422(display_long) psi-mi:"MI:0096"(pull down) Liu et al. (2010) pubmed:20622854|doi:10.1038/nature09272|imex:IM-21508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15864900|imex:IM-21508-7|dip:DIP-191774E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-1560800(isoform-parent)|uniprotkb:Q9UPP1-2(isoform-parent)|ensembl:ENSG00000172943(gene)|ensembl:ENST00000338154(transcript) - psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/14 rogid:VFLb8SCdO/CUJylDbK3j+LN/6aE9606 rogid:6M86IQcphd/YS8g0BNmUqxkx7Bk-2 rigid:V2UwBTP2dEXZ2HB3Fxc/kYhASac false binding-associated region:1-54|his tag:n-n N6,N6-dimethyl-L-lysine:4-4|N6,N6,N6-trimethyl-L-lysine:4-4|biotin tag:0-0 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) intact:EBI-15863530 uniprotkb:Q9NTJ3 dip:DIP-59246N intact:EBI-356173|uniprotkb:A6NLT9|uniprotkb:O95752|uniprotkb:Q8NDL4|uniprotkb:Q9UNT9|uniprotkb:D3DNL8|ensembl:ENSP00000341382|ensembl:ENSP00000349961 psi-mi:h4-2(display_short)|psi-mi:EBI-15863530(display_long) psi-mi:smc4_human(display_long)|uniprotkb:SMC4(gene name)|psi-mi:SMC4(display_short)|uniprotkb:CAPC(gene name synonym)|uniprotkb:SMC4L1(gene name synonym)|uniprotkb:Chromosome-associated polypeptide C(gene name synonym)|uniprotkb:XCAP-C homolog(gene name synonym) psi-mi:"MI:0096"(pull down) Liu et al. (2010) pubmed:20622854|doi:10.1038/nature09272|imex:IM-21508 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15864875|imex:IM-21508-6|dip:DIP-191777E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:NP_001002800.1|refseq:NP_005487.3|refseq:XP_011510613.1|refseq:NP_001275682.1|ensembl:ENSG00000113810(gene)|ensembl:ENST00000344722(transcript)|ensembl:ENST00000357388(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0016607"(nuclear speck)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0051383"(kinetochore organization)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR036277|interpro:IPR041738|mint:Q9NTJ3|rcsb pdb:4U4P|reactome:R-HSA-2299718|reactome:R-HSA-2514853|dip:DIP-32946N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:70QToOgC0sUyRRzZsRe6yR/8LzQ-2 rogid:+2lnTSgTXZwRawJ/ASBRa6EDgv09606 rigid:bnB8OWLg8FBlcm/9RI4EMascyJ0 false N6-methyl-L-lysine:20-20|biotin tag:0-0 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) intact:EBI-15863530 uniprotkb:O95347 dip:DIP-59246N intact:EBI-355822|intact:EBI-1058371|uniprotkb:Q9P1P2|uniprotkb:Q6IEE0|ensembl:ENSP00000286398|ensembl:ENSP00000363919|ensembl:ENSP00000363925 psi-mi:h4-2(display_short)|psi-mi:EBI-15863530(display_long) psi-mi:smc2_human(display_long)|uniprotkb:PRO0324(orf name)|uniprotkb:SMC2(gene name)|psi-mi:SMC2(display_short)|uniprotkb:CAPE(gene name synonym)|uniprotkb:SMC2L1(gene name synonym)|uniprotkb:Chromosome-associated protein E(gene name synonym)|uniprotkb:XCAP-E homolog(gene name synonym) psi-mi:"MI:0096"(pull down) Liu et al. (2010) pubmed:20622854|doi:10.1038/nature09272|imex:IM-21508 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15864875|imex:IM-21508-6|dip:DIP-191777E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:NP_001036015.1|refseq:NP_001036016.1|refseq:NP_006435.2|refseq:XP_011516451.1|refseq:XP_011516455.1|refseq:XP_011516450.1|refseq:NP_001252531.1|refseq:XP_006716996.1|refseq:XP_016869695.1|refseq:XP_016869696.1|refseq:XP_016869697.1|dip:DIP-35422N|ensembl:ENSG00000136824(gene)|ensembl:ENST00000286398(transcript)|ensembl:ENST00000374787(transcript)|ensembl:ENST00000374793(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0051383"(kinetochore organization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027120|interpro:IPR027417|interpro:IPR036277|mint:O95347|rcsb pdb:4U4P|reactome:R-HSA-2299718|reactome:R-HSA-2514853 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:70QToOgC0sUyRRzZsRe6yR/8LzQ-2 rogid:k7RHRDmgiucuAOIfh8vjbqnlv3E9606 rigid:bnB8OWLg8FBlcm/9RI4EMascyJ0 false N6-methyl-L-lysine:20-20|biotin tag:0-0 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) intact:EBI-15863530 uniprotkb:Q6IBW4 dip:DIP-59246N intact:EBI-2548296|ensembl:ENSP00000410088|uniprotkb:Q9BUT3|uniprotkb:Q9BVD1|uniprotkb:B7WPH1|uniprotkb:O43788|uniprotkb:Q13391|uniprotkb:Q96C14|uniprotkb:Q96GJ0|uniprotkb:Q9BQ71 psi-mi:h4-2(display_short)|psi-mi:EBI-15863530(display_long) psi-mi:cndh2_human(display_long)|uniprotkb:NCAPH2(gene name)|psi-mi:NCAPH2(display_short)|uniprotkb:CAPH2(gene name synonym)|uniprotkb:Non-SMC condensin II complex subunit H2(gene name synonym)|uniprotkb:Chromosome-associated protein H2(gene name synonym)|uniprotkb:Kleisin-beta(gene name synonym) psi-mi:"MI:0096"(pull down) Liu et al. (2010) pubmed:20622854|doi:10.1038/nature09272|imex:IM-21508 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15864875|imex:IM-21508-6|dip:DIP-191777E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - ensembl:ENSG00000025770(gene)|ensembl:ENST00000420993(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0016020"(membrane)|go:"GO:0030054"(cell junction)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051306"(mitotic sister chromatid separation)|go:"GO:0051309"(female meiosis chromosome separation)|interpro:IPR009378(Protein of unknown function DUF1032)|interpro:IPR031719|interpro:IPR031737|interpro:IPR031739|mint:Q6IBW4|reactome:R-HSA-2299718|refseq:NP_001171940.1|refseq:NP_055366.3|refseq:NP_689512.2|dip:DIP-43901N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:70QToOgC0sUyRRzZsRe6yR/8LzQ-2 rogid:GTOZg0OoAHm+tj3C8/3sCGM+G5E9606 rigid:bnB8OWLg8FBlcm/9RI4EMascyJ0 false N6-methyl-L-lysine:20-20|biotin tag:0-0 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) intact:EBI-15863530 uniprotkb:Q86XI2 dip:DIP-59246N intact:EBI-1047404|uniprotkb:Q7Z3J9|uniprotkb:Q8WUG8|uniprotkb:Q9BRX6|uniprotkb:Q9H8S2|uniprotkb:Q9H9K6|uniprotkb:A4D228|ensembl:ENSP00000348657|ensembl:ENSP00000386569 psi-mi:h4-2(display_short)|psi-mi:EBI-15863530(display_long) psi-mi:cndg2_human(display_long)|uniprotkb:Chromosome-associated protein G2(gene name synonym)|uniprotkb:Non-SMC condensin II complex subunit G2(gene name synonym)|uniprotkb:Leucine zipper protein 5(gene name synonym)|uniprotkb:NCAPG2(gene name)|psi-mi:NCAPG2(display_short)|uniprotkb:LUZP5(gene name synonym) psi-mi:"MI:0096"(pull down) Liu et al. (2010) pubmed:20622854|doi:10.1038/nature09272|imex:IM-21508 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15864875|imex:IM-21508-6|dip:DIP-191777E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:NP_060230.5|refseq:XP_011514658.1|refseq:XP_011514659.1|ensembl:ENSG00000146918(gene)|ensembl:ENST00000356309(transcript)|ensembl:ENST00000409423(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000796"(condensin complex)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030293"(transmembrane receptor protein tyrosine kinase inhibitor activity)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035064"(methylated histone binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0051301"(cell division)|go:"GO:0140416"(transcription regulator inhibitor activity)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024741|mint:Q86XI2|reactome:R-HSA-2299718|interpro:IPR011989(Armadillo-like helical)|refseq:NP_001268861.1|refseq:NP_001268862.1|dip:DIP-43902N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:70QToOgC0sUyRRzZsRe6yR/8LzQ-2 rogid:4JkTPdyKz1cYblG0ZU0vQKMsuB49606 rigid:bnB8OWLg8FBlcm/9RI4EMascyJ0 false N6-methyl-L-lysine:20-20|biotin tag:0-0 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) intact:EBI-15863530 uniprotkb:P42695 dip:DIP-59246N intact:EBI-722805|uniprotkb:A6NFS2|uniprotkb:Q4KMQ9|ensembl:ENSP00000433681 psi-mi:h4-2(display_short)|psi-mi:EBI-15863530(display_long) psi-mi:cndd3_human(display_long)|uniprotkb:Non-SMC condensin II complex subunit D3(gene name synonym)|uniprotkb:NCAPD3(gene name)|psi-mi:NCAPD3(display_short)|uniprotkb:CAPD3(gene name synonym)|uniprotkb:KIAA0056(gene name synonym) psi-mi:"MI:0096"(pull down) Liu et al. (2010) pubmed:20622854|doi:10.1038/nature09272|imex:IM-21508 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15864875|imex:IM-21508-6|dip:DIP-191777E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:NP_056076.1|dip:DIP-43903N|ensembl:ENSG00000151503(gene)|ensembl:ENST00000534548(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0016020"(membrane)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042393"(histone binding)|go:"GO:0051301"(cell division)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012371(Chromosome condensation protein, HCP-6-related)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026971|interpro:IPR032682|mint:P42695|reactome:R-HSA-2299718 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:70QToOgC0sUyRRzZsRe6yR/8LzQ-2 rogid:z5WYLlrGt33uAM9NRN9SQeHFDaA9606 rigid:bnB8OWLg8FBlcm/9RI4EMascyJ0 false N6-methyl-L-lysine:20-20|biotin tag:0-0 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) intact:EBI-15863530 uniprotkb:Q9NTJ3 dip:DIP-59246N intact:EBI-356173|uniprotkb:A6NLT9|uniprotkb:O95752|uniprotkb:Q8NDL4|uniprotkb:Q9UNT9|uniprotkb:D3DNL8|ensembl:ENSP00000341382|ensembl:ENSP00000349961 psi-mi:h4-2(display_short)|psi-mi:EBI-15863530(display_long) psi-mi:smc4_human(display_long)|uniprotkb:SMC4(gene name)|psi-mi:SMC4(display_short)|uniprotkb:CAPC(gene name synonym)|uniprotkb:SMC4L1(gene name synonym)|uniprotkb:Chromosome-associated polypeptide C(gene name synonym)|uniprotkb:XCAP-C homolog(gene name synonym) psi-mi:"MI:0096"(pull down) Liu et al. (2010) pubmed:20622854|doi:10.1038/nature09272|imex:IM-21508 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15864969|imex:IM-21508-10|dip:DIP-191778E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:NP_001002800.1|refseq:NP_005487.3|refseq:XP_011510613.1|refseq:NP_001275682.1|ensembl:ENSG00000113810(gene)|ensembl:ENST00000344722(transcript)|ensembl:ENST00000357388(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0016607"(nuclear speck)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0051383"(kinetochore organization)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR036277|interpro:IPR041738|mint:Q9NTJ3|rcsb pdb:4U4P|reactome:R-HSA-2299718|reactome:R-HSA-2514853|dip:DIP-32946N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:70QToOgC0sUyRRzZsRe6yR/8LzQ-2 rogid:+2lnTSgTXZwRawJ/ASBRa6EDgv09606 rigid:h4V1wRgtdc3SenltTYUDOyuBbOE false N6-methyl-L-lysine:20-20|biotin tag:0-0 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) intact:EBI-15863530 uniprotkb:O95347 dip:DIP-59246N intact:EBI-355822|intact:EBI-1058371|uniprotkb:Q9P1P2|uniprotkb:Q6IEE0|ensembl:ENSP00000286398|ensembl:ENSP00000363919|ensembl:ENSP00000363925 psi-mi:h4-2(display_short)|psi-mi:EBI-15863530(display_long) psi-mi:smc2_human(display_long)|uniprotkb:PRO0324(orf name)|uniprotkb:SMC2(gene name)|psi-mi:SMC2(display_short)|uniprotkb:CAPE(gene name synonym)|uniprotkb:SMC2L1(gene name synonym)|uniprotkb:Chromosome-associated protein E(gene name synonym)|uniprotkb:XCAP-E homolog(gene name synonym) psi-mi:"MI:0096"(pull down) Liu et al. (2010) pubmed:20622854|doi:10.1038/nature09272|imex:IM-21508 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15864969|imex:IM-21508-10|dip:DIP-191778E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:NP_001036015.1|refseq:NP_001036016.1|refseq:NP_006435.2|refseq:XP_011516451.1|refseq:XP_011516455.1|refseq:XP_011516450.1|refseq:NP_001252531.1|refseq:XP_006716996.1|refseq:XP_016869695.1|refseq:XP_016869696.1|refseq:XP_016869697.1|dip:DIP-35422N|ensembl:ENSG00000136824(gene)|ensembl:ENST00000286398(transcript)|ensembl:ENST00000374787(transcript)|ensembl:ENST00000374793(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0051383"(kinetochore organization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027120|interpro:IPR027417|interpro:IPR036277|mint:O95347|rcsb pdb:4U4P|reactome:R-HSA-2299718|reactome:R-HSA-2514853 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:70QToOgC0sUyRRzZsRe6yR/8LzQ-2 rogid:k7RHRDmgiucuAOIfh8vjbqnlv3E9606 rigid:h4V1wRgtdc3SenltTYUDOyuBbOE false N6-methyl-L-lysine:20-20|biotin tag:0-0 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) intact:EBI-15863530 uniprotkb:Q86XI2 dip:DIP-59246N intact:EBI-1047404|uniprotkb:Q7Z3J9|uniprotkb:Q8WUG8|uniprotkb:Q9BRX6|uniprotkb:Q9H8S2|uniprotkb:Q9H9K6|uniprotkb:A4D228|ensembl:ENSP00000348657|ensembl:ENSP00000386569 psi-mi:h4-2(display_short)|psi-mi:EBI-15863530(display_long) psi-mi:cndg2_human(display_long)|uniprotkb:Chromosome-associated protein G2(gene name synonym)|uniprotkb:Non-SMC condensin II complex subunit G2(gene name synonym)|uniprotkb:Leucine zipper protein 5(gene name synonym)|uniprotkb:NCAPG2(gene name)|psi-mi:NCAPG2(display_short)|uniprotkb:LUZP5(gene name synonym) psi-mi:"MI:0096"(pull down) Liu et al. (2010) pubmed:20622854|doi:10.1038/nature09272|imex:IM-21508 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15864969|imex:IM-21508-10|dip:DIP-191778E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:NP_060230.5|refseq:XP_011514658.1|refseq:XP_011514659.1|ensembl:ENSG00000146918(gene)|ensembl:ENST00000356309(transcript)|ensembl:ENST00000409423(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000796"(condensin complex)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030293"(transmembrane receptor protein tyrosine kinase inhibitor activity)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035064"(methylated histone binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0051301"(cell division)|go:"GO:0140416"(transcription regulator inhibitor activity)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024741|mint:Q86XI2|reactome:R-HSA-2299718|interpro:IPR011989(Armadillo-like helical)|refseq:NP_001268861.1|refseq:NP_001268862.1|dip:DIP-43902N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:70QToOgC0sUyRRzZsRe6yR/8LzQ-2 rogid:4JkTPdyKz1cYblG0ZU0vQKMsuB49606 rigid:h4V1wRgtdc3SenltTYUDOyuBbOE false N6-methyl-L-lysine:20-20|biotin tag:0-0 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)