#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q15116	uniprotkb:Q9NZQ7	intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym)	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Ghiotto et al. (2010)	pubmed:20587542|imex:IM-26317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16511370|imex:IM-26317-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	-	-	-	figure legend:Table 1, fig 1, 2, Supp fig 2/3|kinetics:The conformational change model gave the best and reliable fit.|comment:"Pre-incubation of PD-L1 with three different antibodies against it influenced the interaction outcome. One of the anitbodies (PD-L1.3) disrupted binding, while the ohter two (PD-L1.1 and PD-L1.2) seemed to strengthen it, probably by increasing PD-L1 stability."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:10.4x10^-9(molar)	2017/10/12	2017/10/23	rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rigid:UCghd0MiNpAZwi8Qa4DDpPh4u+o	false	sufficient binding region:1-152|fc-igg tag:?-?	sufficient binding region:1..19-228..239|fc-igg tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15116	uniprotkb:Q9BQ51	intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684	intact:EBI-16427978|ensembl:ENSP00000380855|uniprotkb:Q14CN8|uniprotkb:Q5T7Z6|uniprotkb:Q6JXL8|uniprotkb:Q6JXL9	psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym)	psi-mi:pd1l2_human(display_long)|uniprotkb:Butyrophilin B7-DC(gene name synonym)|uniprotkb:PDCD1LG2(gene name)|psi-mi:PDCD1LG2(display_short)|uniprotkb:B7DC(gene name synonym)|uniprotkb:CD273(gene name synonym)|uniprotkb:PDCD1L2(gene name synonym)|uniprotkb:PDL2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Ghiotto et al. (2010)	pubmed:20587542|imex:IM-26317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16512166|imex:IM-26317-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N	ensembl:ENSG00000197646(gene)|ensembl:ENST00000397747(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6UMT|reactome:R-HSA-389948|refseq:NP_079515.2	-	-	-	figure legend:Table 1, fig 1,3, Supp fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:11.3x10^-9(molar)	2017/10/12	2017/10/23	rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606	rogid:8VYU/YGsl0tu2fwuMftHWRKZutQ9606	rigid:wbe4rMplCkX7GCZdNRNNN5JGaE8	false	sufficient binding region:1-152|fc-igg tag:?-?	sufficient binding region:1-208|fc-igg tag:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15116	uniprotkb:Q9NZQ7	intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym)	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Ghiotto et al. (2010)	pubmed:20587542|imex:IM-26317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16517379|imex:IM-26317-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	-	-	-	figure legend:Fig 3A -top|comment:PD-L1 can out-compete PD-L2 following saturation of PD-L2 occupancy|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/10/12	2017/10/23	rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rigid:YyAvJtosyiNGOHsQM53uhiKFPqU	false	sufficient binding region:1-152|fc-igg tag:?-?	fc-igg tag:?-?|sufficient binding region:1..29-228..239	1	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15116	uniprotkb:Q9BQ51	intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684	intact:EBI-16427978|ensembl:ENSP00000380855|uniprotkb:Q14CN8|uniprotkb:Q5T7Z6|uniprotkb:Q6JXL8|uniprotkb:Q6JXL9	psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym)	psi-mi:pd1l2_human(display_long)|uniprotkb:Butyrophilin B7-DC(gene name synonym)|uniprotkb:PDCD1LG2(gene name)|psi-mi:PDCD1LG2(display_short)|uniprotkb:B7DC(gene name synonym)|uniprotkb:CD273(gene name synonym)|uniprotkb:PDCD1L2(gene name synonym)|uniprotkb:PDL2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Ghiotto et al. (2010)	pubmed:20587542|imex:IM-26317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16517379|imex:IM-26317-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N	ensembl:ENSG00000197646(gene)|ensembl:ENST00000397747(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6UMT|reactome:R-HSA-389948|refseq:NP_079515.2	-	-	-	figure legend:Fig 3A -top|comment:PD-L1 can out-compete PD-L2 following saturation of PD-L2 occupancy|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/10/12	2017/10/23	rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606	rogid:8VYU/YGsl0tu2fwuMftHWRKZutQ9606	rigid:YyAvJtosyiNGOHsQM53uhiKFPqU	false	sufficient binding region:1-152|fc-igg tag:?-?	sufficient binding region:1-208|fc-igg tag:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NZQ7	uniprotkb:Q15116	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Ghiotto et al. (2010)	pubmed:20587542|imex:IM-26317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16517398|imex:IM-26317-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N	-	-	-	figure legend:Fig 3A -middle|comment:PD-1 proteins were pre-incubated with PD-L2 and the resulting complexes were injected  onto PD-L1-Ig chips;PD-L2 pre-incubation prevented PD-1 binding to PD-L1 in a dose-dependent manner|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/10/12	2017/10/23	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606	rigid:YyAvJtosyiNGOHsQM53uhiKFPqU	false	fc-igg tag:?-?|sufficient binding region:1..29-228..239	sufficient binding region:1-152|fc-igg tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NZQ7	uniprotkb:Q9BQ51	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	intact:EBI-16427978|ensembl:ENSP00000380855|uniprotkb:Q14CN8|uniprotkb:Q5T7Z6|uniprotkb:Q6JXL8|uniprotkb:Q6JXL9	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:pd1l2_human(display_long)|uniprotkb:Butyrophilin B7-DC(gene name synonym)|uniprotkb:PDCD1LG2(gene name)|psi-mi:PDCD1LG2(display_short)|uniprotkb:B7DC(gene name synonym)|uniprotkb:CD273(gene name synonym)|uniprotkb:PDCD1L2(gene name synonym)|uniprotkb:PDL2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Ghiotto et al. (2010)	pubmed:20587542|imex:IM-26317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16517398|imex:IM-26317-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	ensembl:ENSG00000197646(gene)|ensembl:ENST00000397747(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6UMT|reactome:R-HSA-389948|refseq:NP_079515.2	-	-	-	figure legend:Fig 3A -middle|comment:PD-1 proteins were pre-incubated with PD-L2 and the resulting complexes were injected  onto PD-L1-Ig chips;PD-L2 pre-incubation prevented PD-1 binding to PD-L1 in a dose-dependent manner|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/10/12	2017/10/23	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rogid:8VYU/YGsl0tu2fwuMftHWRKZutQ9606	rigid:YyAvJtosyiNGOHsQM53uhiKFPqU	false	fc-igg tag:?-?|sufficient binding region:1..29-228..239	sufficient binding region:1-208|fc-igg tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P33681	uniprotkb:Q9NZQ7	intact:EBI-1031024|ensembl:ENSP00000264246|ensembl:ENSP00000418364|uniprotkb:Q5DTA9|uniprotkb:Q5DTB0	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	psi-mi:cd80_human(display_long)|uniprotkb:CD80(gene name)|psi-mi:CD80(display_short)|uniprotkb:CD28LG(gene name synonym)|uniprotkb:CD28LG1(gene name synonym)|uniprotkb:LAB7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.1(gene name synonym)|uniprotkb:BB1(gene name synonym)	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Ghiotto et al. (2010)	pubmed:20587542|imex:IM-26317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16517480|imex:IM-26317-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005182.1|ensembl:ENSG00000121594(gene)|ensembl:ENST00000264246(transcript)|ensembl:ENST00000478182(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:1DR9|rcsb pdb:1I8L|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-6783783|reactome:R-HSA-6811558|dip:DIP-6044N	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	-	-	-	figure legend:Fig 1A, 3, Table 1|comment:the parameters of PD-L1 binding to CD80 fitted also with the conformational change model.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.2x10^-9(molar)	2017/10/12	2017/10/23	rogid:ZKA9ziAUnKDmzBpyUysM9BfJLy09606	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rigid:dekVHLAYv5FV/AAjOd9C0tdWZRs	false	fc-igg tag:c-c|his tag:c-c|sufficient binding region:35-242	fc-igg tag:?-?|sufficient binding region:1..19-228..239	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P33681	uniprotkb:P16410	intact:EBI-1031024|ensembl:ENSP00000264246|ensembl:ENSP00000418364|uniprotkb:Q5DTA9|uniprotkb:Q5DTB0	intact:EBI-1030991|uniprotkb:Q53TD5|uniprotkb:Q8WXJ1|uniprotkb:Q96P43|uniprotkb:Q9UKN9|ensembl:ENSP00000497102|uniprotkb:A0N1S0|uniprotkb:E9PDH0|uniprotkb:Q0PP65|uniprotkb:Q52MC1|uniprotkb:Q5S005|uniprotkb:O95653	psi-mi:cd80_human(display_long)|uniprotkb:CD80(gene name)|psi-mi:CD80(display_short)|uniprotkb:CD28LG(gene name synonym)|uniprotkb:CD28LG1(gene name synonym)|uniprotkb:LAB7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.1(gene name synonym)|uniprotkb:BB1(gene name synonym)	psi-mi:ctla4_human(display_long)|uniprotkb:CTLA4(gene name)|psi-mi:CTLA4(display_short)|uniprotkb:CD152(gene name synonym)|uniprotkb:Cytotoxic T-lymphocyte-associated antigen 4(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Ghiotto et al. (2010)	pubmed:20587542|imex:IM-26317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16517501|imex:IM-26317-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005182.1|ensembl:ENSG00000121594(gene)|ensembl:ENST00000264246(transcript)|ensembl:ENST00000478182(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:1DR9|rcsb pdb:1I8L|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-6783783|reactome:R-HSA-6811558|dip:DIP-6044N	ensembl:ENST00000648405(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0098636"(protein complex involved in cell adhesion)|ensembl:ENSG00000163599(gene)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR008096(Cytotoxic T-lymphocyte antigen 4)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040216|rcsb pdb:1AH1|rcsb pdb:1H6E|rcsb pdb:1I85|rcsb pdb:1I8L|rcsb pdb:2X44|rcsb pdb:3BX7|rcsb pdb:3OSK|rcsb pdb:5GGV|rcsb pdb:5TRU|rcsb pdb:5XJ3|rcsb pdb:6RP8|rcsb pdb:6RPJ|rcsb pdb:6RQM|rcsb pdb:6XY2|rcsb pdb:7CIO|rcsb pdb:7ELX|reactome:R-HSA-389513|reactome:R-HSA-8877330|refseq:NP_001032720.1|refseq:NP_005205.2|dip:DIP-35607N	-	-	-	figure legend:Fig 1A, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.46x10^-9(molar)	2017/10/12	2017/10/23	rogid:ZKA9ziAUnKDmzBpyUysM9BfJLy09606	rogid:PeBR/2EG/cFzR4DKWuX80TsgBw49606	rigid:9Maubx1fz7zswwgnBtgVx+DUHXE	false	fc-igg tag:c-c|his tag:c-c|sufficient binding region:35-242	sufficient binding region:1-162|fc-igg tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P33681	uniprotkb:Q15116	intact:EBI-1031024|ensembl:ENSP00000264246|ensembl:ENSP00000418364|uniprotkb:Q5DTA9|uniprotkb:Q5DTB0	intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684	psi-mi:cd80_human(display_long)|uniprotkb:CD80(gene name)|psi-mi:CD80(display_short)|uniprotkb:CD28LG(gene name synonym)|uniprotkb:CD28LG1(gene name synonym)|uniprotkb:LAB7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.1(gene name synonym)|uniprotkb:BB1(gene name synonym)	psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Ghiotto et al. (2010)	pubmed:20587542|imex:IM-26317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16517530|imex:IM-26317-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005182.1|ensembl:ENSG00000121594(gene)|ensembl:ENST00000264246(transcript)|ensembl:ENST00000478182(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:1DR9|rcsb pdb:1I8L|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-6783783|reactome:R-HSA-6811558|dip:DIP-6044N	refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N	-	-	-	figure legend:3A bottom|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.2x10^-9(molar)	2017/10/12	2017/10/23	rogid:ZKA9ziAUnKDmzBpyUysM9BfJLy09606	rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606	rigid:UwLteP4h8mS4/aVM2WSe1JyTtTE	false	fc-igg tag:c-c|his tag:c-c|sufficient binding region:35-242	fc-igg tag:?-?|sufficient binding region:1-152	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P33681	uniprotkb:Q9NZQ7	intact:EBI-1031024|ensembl:ENSP00000264246|ensembl:ENSP00000418364|uniprotkb:Q5DTA9|uniprotkb:Q5DTB0	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	psi-mi:cd80_human(display_long)|uniprotkb:CD80(gene name)|psi-mi:CD80(display_short)|uniprotkb:CD28LG(gene name synonym)|uniprotkb:CD28LG1(gene name synonym)|uniprotkb:LAB7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.1(gene name synonym)|uniprotkb:BB1(gene name synonym)	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Ghiotto et al. (2010)	pubmed:20587542|imex:IM-26317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16517530|imex:IM-26317-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005182.1|ensembl:ENSG00000121594(gene)|ensembl:ENST00000264246(transcript)|ensembl:ENST00000478182(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:1DR9|rcsb pdb:1I8L|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-6783783|reactome:R-HSA-6811558|dip:DIP-6044N	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	-	-	-	figure legend:3A bottom|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.2x10^-9(molar)	2017/10/12	2017/10/23	rogid:ZKA9ziAUnKDmzBpyUysM9BfJLy09606	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rigid:UwLteP4h8mS4/aVM2WSe1JyTtTE	false	fc-igg tag:c-c|his tag:c-c|sufficient binding region:35-242	fc-igg tag:?-?|sufficient binding region:1..19-228..239	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NZQ7	uniprotkb:P16410	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	intact:EBI-1030991|uniprotkb:Q53TD5|uniprotkb:Q8WXJ1|uniprotkb:Q96P43|uniprotkb:Q9UKN9|ensembl:ENSP00000497102|uniprotkb:A0N1S0|uniprotkb:E9PDH0|uniprotkb:Q0PP65|uniprotkb:Q52MC1|uniprotkb:Q5S005|uniprotkb:O95653	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:ctla4_human(display_long)|uniprotkb:CTLA4(gene name)|psi-mi:CTLA4(display_short)|uniprotkb:CD152(gene name synonym)|uniprotkb:Cytotoxic T-lymphocyte-associated antigen 4(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Ghiotto et al. (2010)	pubmed:20587542|imex:IM-26317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16517551|imex:IM-26317-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	ensembl:ENST00000648405(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0098636"(protein complex involved in cell adhesion)|ensembl:ENSG00000163599(gene)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR008096(Cytotoxic T-lymphocyte antigen 4)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040216|rcsb pdb:1AH1|rcsb pdb:1H6E|rcsb pdb:1I85|rcsb pdb:1I8L|rcsb pdb:2X44|rcsb pdb:3BX7|rcsb pdb:3OSK|rcsb pdb:5GGV|rcsb pdb:5TRU|rcsb pdb:5XJ3|rcsb pdb:6RP8|rcsb pdb:6RPJ|rcsb pdb:6RQM|rcsb pdb:6XY2|rcsb pdb:7CIO|rcsb pdb:7ELX|reactome:R-HSA-389513|reactome:R-HSA-8877330|refseq:NP_001032720.1|refseq:NP_005205.2|dip:DIP-35607N	-	-	-	figure legend:Supp fig 4-2|comment:CTLA-4 cannot directly bind to PD-L1 chip but strongly bind to CD80/PD-L1 complexes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/10/12	2017/10/23	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rogid:PeBR/2EG/cFzR4DKWuX80TsgBw49606	rigid:YizYkxiVRzJA8EWtPUbI5t1CR2Y	false	sufficient binding region:1..19-228..239|fc-igg tag:?-?	sufficient binding region:1-162|fc-igg tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NZQ7	uniprotkb:P33681	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	intact:EBI-1031024|ensembl:ENSP00000264246|ensembl:ENSP00000418364|uniprotkb:Q5DTA9|uniprotkb:Q5DTB0	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:cd80_human(display_long)|uniprotkb:CD80(gene name)|psi-mi:CD80(display_short)|uniprotkb:CD28LG(gene name synonym)|uniprotkb:CD28LG1(gene name synonym)|uniprotkb:LAB7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.1(gene name synonym)|uniprotkb:BB1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Ghiotto et al. (2010)	pubmed:20587542|imex:IM-26317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16517551|imex:IM-26317-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	refseq:NP_005182.1|ensembl:ENSG00000121594(gene)|ensembl:ENST00000264246(transcript)|ensembl:ENST00000478182(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:1DR9|rcsb pdb:1I8L|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-6783783|reactome:R-HSA-6811558|dip:DIP-6044N	-	-	-	figure legend:Supp fig 4-2|comment:CTLA-4 cannot directly bind to PD-L1 chip but strongly bind to CD80/PD-L1 complexes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/10/12	2017/10/23	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rogid:ZKA9ziAUnKDmzBpyUysM9BfJLy09606	rigid:YizYkxiVRzJA8EWtPUbI5t1CR2Y	false	sufficient binding region:1..19-228..239|fc-igg tag:?-?	fc-igg tag:c-c|his tag:c-c|sufficient binding region:35-242	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P33681	uniprotkb:P16410	intact:EBI-1031024|ensembl:ENSP00000264246|ensembl:ENSP00000418364|uniprotkb:Q5DTA9|uniprotkb:Q5DTB0	intact:EBI-1030991|uniprotkb:Q53TD5|uniprotkb:Q8WXJ1|uniprotkb:Q96P43|uniprotkb:Q9UKN9|ensembl:ENSP00000497102|uniprotkb:A0N1S0|uniprotkb:E9PDH0|uniprotkb:Q0PP65|uniprotkb:Q52MC1|uniprotkb:Q5S005|uniprotkb:O95653	psi-mi:cd80_human(display_long)|uniprotkb:CD80(gene name)|psi-mi:CD80(display_short)|uniprotkb:CD28LG(gene name synonym)|uniprotkb:CD28LG1(gene name synonym)|uniprotkb:LAB7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.1(gene name synonym)|uniprotkb:BB1(gene name synonym)	psi-mi:ctla4_human(display_long)|uniprotkb:CTLA4(gene name)|psi-mi:CTLA4(display_short)|uniprotkb:CD152(gene name synonym)|uniprotkb:Cytotoxic T-lymphocyte-associated antigen 4(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Ghiotto et al. (2010)	pubmed:20587542|imex:IM-26317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16517573|imex:IM-26317-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005182.1|ensembl:ENSG00000121594(gene)|ensembl:ENST00000264246(transcript)|ensembl:ENST00000478182(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:1DR9|rcsb pdb:1I8L|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-6783783|reactome:R-HSA-6811558|dip:DIP-6044N	ensembl:ENST00000648405(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0098636"(protein complex involved in cell adhesion)|ensembl:ENSG00000163599(gene)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR008096(Cytotoxic T-lymphocyte antigen 4)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040216|rcsb pdb:1AH1|rcsb pdb:1H6E|rcsb pdb:1I85|rcsb pdb:1I8L|rcsb pdb:2X44|rcsb pdb:3BX7|rcsb pdb:3OSK|rcsb pdb:5GGV|rcsb pdb:5TRU|rcsb pdb:5XJ3|rcsb pdb:6RP8|rcsb pdb:6RPJ|rcsb pdb:6RQM|rcsb pdb:6XY2|rcsb pdb:7CIO|rcsb pdb:7ELX|reactome:R-HSA-389513|reactome:R-HSA-8877330|refseq:NP_001032720.1|refseq:NP_005205.2|dip:DIP-35607N	-	-	-	figure legend:Fig 3B bottom|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/10/12	2017/10/23	rogid:ZKA9ziAUnKDmzBpyUysM9BfJLy09606	rogid:PeBR/2EG/cFzR4DKWuX80TsgBw49606	rigid:9Maubx1fz7zswwgnBtgVx+DUHXE	false	fc-igg tag:c-c|his tag:c-c|sufficient binding region:35-242	sufficient binding region:1-162|fc-igg tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P33681	uniprotkb:P16410	intact:EBI-1031024|ensembl:ENSP00000264246|ensembl:ENSP00000418364|uniprotkb:Q5DTA9|uniprotkb:Q5DTB0	intact:EBI-1030991|uniprotkb:Q53TD5|uniprotkb:Q8WXJ1|uniprotkb:Q96P43|uniprotkb:Q9UKN9|ensembl:ENSP00000497102|uniprotkb:A0N1S0|uniprotkb:E9PDH0|uniprotkb:Q0PP65|uniprotkb:Q52MC1|uniprotkb:Q5S005|uniprotkb:O95653	psi-mi:cd80_human(display_long)|uniprotkb:CD80(gene name)|psi-mi:CD80(display_short)|uniprotkb:CD28LG(gene name synonym)|uniprotkb:CD28LG1(gene name synonym)|uniprotkb:LAB7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.1(gene name synonym)|uniprotkb:BB1(gene name synonym)	psi-mi:ctla4_human(display_long)|uniprotkb:CTLA4(gene name)|psi-mi:CTLA4(display_short)|uniprotkb:CD152(gene name synonym)|uniprotkb:Cytotoxic T-lymphocyte-associated antigen 4(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Ghiotto et al. (2010)	pubmed:20587542|imex:IM-26317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16517573|imex:IM-26317-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005182.1|ensembl:ENSG00000121594(gene)|ensembl:ENST00000264246(transcript)|ensembl:ENST00000478182(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:1DR9|rcsb pdb:1I8L|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-6783783|reactome:R-HSA-6811558|dip:DIP-6044N	ensembl:ENST00000648405(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0098636"(protein complex involved in cell adhesion)|ensembl:ENSG00000163599(gene)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR008096(Cytotoxic T-lymphocyte antigen 4)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040216|rcsb pdb:1AH1|rcsb pdb:1H6E|rcsb pdb:1I85|rcsb pdb:1I8L|rcsb pdb:2X44|rcsb pdb:3BX7|rcsb pdb:3OSK|rcsb pdb:5GGV|rcsb pdb:5TRU|rcsb pdb:5XJ3|rcsb pdb:6RP8|rcsb pdb:6RPJ|rcsb pdb:6RQM|rcsb pdb:6XY2|rcsb pdb:7CIO|rcsb pdb:7ELX|reactome:R-HSA-389513|reactome:R-HSA-8877330|refseq:NP_001032720.1|refseq:NP_005205.2|dip:DIP-35607N	-	-	-	figure legend:Fig 3B bottom|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/10/12	2017/10/23	rogid:ZKA9ziAUnKDmzBpyUysM9BfJLy09606	rogid:PeBR/2EG/cFzR4DKWuX80TsgBw49606	rigid:9Maubx1fz7zswwgnBtgVx+DUHXE	false	fc-igg tag:c-c|his tag:c-c|sufficient binding region:35-242	sufficient binding region:1-162|fc-igg tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NZQ7	uniprotkb:P33681	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	intact:EBI-1031024|ensembl:ENSP00000264246|ensembl:ENSP00000418364|uniprotkb:Q5DTA9|uniprotkb:Q5DTB0	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:cd80_human(display_long)|uniprotkb:CD80(gene name)|psi-mi:CD80(display_short)|uniprotkb:CD28LG(gene name synonym)|uniprotkb:CD28LG1(gene name synonym)|uniprotkb:LAB7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.1(gene name synonym)|uniprotkb:BB1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Ghiotto et al. (2010)	pubmed:20587542|imex:IM-26317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16517599|imex:IM-26317-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	refseq:NP_005182.1|ensembl:ENSG00000121594(gene)|ensembl:ENST00000264246(transcript)|ensembl:ENST00000478182(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:1DR9|rcsb pdb:1I8L|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-6783783|reactome:R-HSA-6811558|dip:DIP-6044N	-	-	-	figure legend:Supp fig 4-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/10/12	2017/10/23	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rogid:ZKA9ziAUnKDmzBpyUysM9BfJLy09606	rigid:dekVHLAYv5FV/AAjOd9C0tdWZRs	false	sufficient binding region:1..19-228..239|fc-igg tag:?-?	fc-igg tag:c-c|his tag:c-c|sufficient binding region:35-242	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16410	uniprotkb:Q9NZQ7	intact:EBI-1030991|uniprotkb:Q53TD5|uniprotkb:Q8WXJ1|uniprotkb:Q96P43|uniprotkb:Q9UKN9|ensembl:ENSP00000497102|uniprotkb:A0N1S0|uniprotkb:E9PDH0|uniprotkb:Q0PP65|uniprotkb:Q52MC1|uniprotkb:Q5S005|uniprotkb:O95653	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	psi-mi:ctla4_human(display_long)|uniprotkb:CTLA4(gene name)|psi-mi:CTLA4(display_short)|uniprotkb:CD152(gene name synonym)|uniprotkb:Cytotoxic T-lymphocyte-associated antigen 4(gene name synonym)	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Ghiotto et al. (2010)	pubmed:20587542|imex:IM-26317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16517740|imex:IM-26317-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000648405(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0098636"(protein complex involved in cell adhesion)|ensembl:ENSG00000163599(gene)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR008096(Cytotoxic T-lymphocyte antigen 4)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040216|rcsb pdb:1AH1|rcsb pdb:1H6E|rcsb pdb:1I85|rcsb pdb:1I8L|rcsb pdb:2X44|rcsb pdb:3BX7|rcsb pdb:3OSK|rcsb pdb:5GGV|rcsb pdb:5TRU|rcsb pdb:5XJ3|rcsb pdb:6RP8|rcsb pdb:6RPJ|rcsb pdb:6RQM|rcsb pdb:6XY2|rcsb pdb:7CIO|rcsb pdb:7ELX|reactome:R-HSA-389513|reactome:R-HSA-8877330|refseq:NP_001032720.1|refseq:NP_005205.2|dip:DIP-35607N	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	-	-	-	figure legend:Supp fig 5|comment:CTLA-4 and PD-L1 can bind to human CD80 simultaneously|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/10/12	2017/10/24	rogid:PeBR/2EG/cFzR4DKWuX80TsgBw49606	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rigid:YizYkxiVRzJA8EWtPUbI5t1CR2Y	false	sufficient binding region:1-162|fc-igg tag:?-?	sufficient binding region:1..19-228..239|fc-igg tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16410	uniprotkb:P33681	intact:EBI-1030991|uniprotkb:Q53TD5|uniprotkb:Q8WXJ1|uniprotkb:Q96P43|uniprotkb:Q9UKN9|ensembl:ENSP00000497102|uniprotkb:A0N1S0|uniprotkb:E9PDH0|uniprotkb:Q0PP65|uniprotkb:Q52MC1|uniprotkb:Q5S005|uniprotkb:O95653	intact:EBI-1031024|ensembl:ENSP00000264246|ensembl:ENSP00000418364|uniprotkb:Q5DTA9|uniprotkb:Q5DTB0	psi-mi:ctla4_human(display_long)|uniprotkb:CTLA4(gene name)|psi-mi:CTLA4(display_short)|uniprotkb:CD152(gene name synonym)|uniprotkb:Cytotoxic T-lymphocyte-associated antigen 4(gene name synonym)	psi-mi:cd80_human(display_long)|uniprotkb:CD80(gene name)|psi-mi:CD80(display_short)|uniprotkb:CD28LG(gene name synonym)|uniprotkb:CD28LG1(gene name synonym)|uniprotkb:LAB7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.1(gene name synonym)|uniprotkb:BB1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Ghiotto et al. (2010)	pubmed:20587542|imex:IM-26317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16517740|imex:IM-26317-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000648405(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0098636"(protein complex involved in cell adhesion)|ensembl:ENSG00000163599(gene)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR008096(Cytotoxic T-lymphocyte antigen 4)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040216|rcsb pdb:1AH1|rcsb pdb:1H6E|rcsb pdb:1I85|rcsb pdb:1I8L|rcsb pdb:2X44|rcsb pdb:3BX7|rcsb pdb:3OSK|rcsb pdb:5GGV|rcsb pdb:5TRU|rcsb pdb:5XJ3|rcsb pdb:6RP8|rcsb pdb:6RPJ|rcsb pdb:6RQM|rcsb pdb:6XY2|rcsb pdb:7CIO|rcsb pdb:7ELX|reactome:R-HSA-389513|reactome:R-HSA-8877330|refseq:NP_001032720.1|refseq:NP_005205.2|dip:DIP-35607N	refseq:NP_005182.1|ensembl:ENSG00000121594(gene)|ensembl:ENST00000264246(transcript)|ensembl:ENST00000478182(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:1DR9|rcsb pdb:1I8L|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-6783783|reactome:R-HSA-6811558|dip:DIP-6044N	-	-	-	figure legend:Supp fig 5|comment:CTLA-4 and PD-L1 can bind to human CD80 simultaneously|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/10/12	2017/10/24	rogid:PeBR/2EG/cFzR4DKWuX80TsgBw49606	rogid:ZKA9ziAUnKDmzBpyUysM9BfJLy09606	rigid:YizYkxiVRzJA8EWtPUbI5t1CR2Y	false	sufficient binding region:1-162|fc-igg tag:?-?	fc-igg tag:c-c|his tag:c-c|sufficient binding region:35-242	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P33681	uniprotkb:P16410	intact:EBI-1031024|ensembl:ENSP00000264246|ensembl:ENSP00000418364|uniprotkb:Q5DTA9|uniprotkb:Q5DTB0	intact:EBI-1030991|uniprotkb:Q53TD5|uniprotkb:Q8WXJ1|uniprotkb:Q96P43|uniprotkb:Q9UKN9|ensembl:ENSP00000497102|uniprotkb:A0N1S0|uniprotkb:E9PDH0|uniprotkb:Q0PP65|uniprotkb:Q52MC1|uniprotkb:Q5S005|uniprotkb:O95653	psi-mi:cd80_human(display_long)|uniprotkb:CD80(gene name)|psi-mi:CD80(display_short)|uniprotkb:CD28LG(gene name synonym)|uniprotkb:CD28LG1(gene name synonym)|uniprotkb:LAB7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.1(gene name synonym)|uniprotkb:BB1(gene name synonym)	psi-mi:ctla4_human(display_long)|uniprotkb:CTLA4(gene name)|psi-mi:CTLA4(display_short)|uniprotkb:CD152(gene name synonym)|uniprotkb:Cytotoxic T-lymphocyte-associated antigen 4(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Ghiotto et al. (2010)	pubmed:20587542|imex:IM-26317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16517417|imex:IM-26317-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005182.1|ensembl:ENSG00000121594(gene)|ensembl:ENST00000264246(transcript)|ensembl:ENST00000478182(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:1DR9|rcsb pdb:1I8L|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-6783783|reactome:R-HSA-6811558|dip:DIP-6044N	ensembl:ENST00000648405(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0098636"(protein complex involved in cell adhesion)|ensembl:ENSG00000163599(gene)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR008096(Cytotoxic T-lymphocyte antigen 4)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040216|rcsb pdb:1AH1|rcsb pdb:1H6E|rcsb pdb:1I85|rcsb pdb:1I8L|rcsb pdb:2X44|rcsb pdb:3BX7|rcsb pdb:3OSK|rcsb pdb:5GGV|rcsb pdb:5TRU|rcsb pdb:5XJ3|rcsb pdb:6RP8|rcsb pdb:6RPJ|rcsb pdb:6RQM|rcsb pdb:6XY2|rcsb pdb:7CIO|rcsb pdb:7ELX|reactome:R-HSA-389513|reactome:R-HSA-8877330|refseq:NP_001032720.1|refseq:NP_005205.2|dip:DIP-35607N	-	-	-	figure legend:Fig 3C top|comment:It is not stated if the PD-L1 molecule  was full length or ECD only.|comment:CTLA-4-Ig can bind to PD-L1 expressing COS cells in presence of CD80 but not PD-1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/10/12	2017/10/23	rogid:ZKA9ziAUnKDmzBpyUysM9BfJLy09606	rogid:PeBR/2EG/cFzR4DKWuX80TsgBw49606	rigid:YizYkxiVRzJA8EWtPUbI5t1CR2Y	false	fc-igg tag:c-c|his tag:c-c|sufficient binding region:35-242	biotin tag:?-?|sufficient binding region:1-162|fc-igg tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P33681	uniprotkb:Q9NZQ7	intact:EBI-1031024|ensembl:ENSP00000264246|ensembl:ENSP00000418364|uniprotkb:Q5DTA9|uniprotkb:Q5DTB0	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	psi-mi:cd80_human(display_long)|uniprotkb:CD80(gene name)|psi-mi:CD80(display_short)|uniprotkb:CD28LG(gene name synonym)|uniprotkb:CD28LG1(gene name synonym)|uniprotkb:LAB7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.1(gene name synonym)|uniprotkb:BB1(gene name synonym)	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Ghiotto et al. (2010)	pubmed:20587542|imex:IM-26317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16517417|imex:IM-26317-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005182.1|ensembl:ENSG00000121594(gene)|ensembl:ENST00000264246(transcript)|ensembl:ENST00000478182(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:1DR9|rcsb pdb:1I8L|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-6783783|reactome:R-HSA-6811558|dip:DIP-6044N	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	-	-	-	figure legend:Fig 3C top|comment:It is not stated if the PD-L1 molecule  was full length or ECD only.|comment:CTLA-4-Ig can bind to PD-L1 expressing COS cells in presence of CD80 but not PD-1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/10/12	2017/10/23	rogid:ZKA9ziAUnKDmzBpyUysM9BfJLy09606	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rigid:YizYkxiVRzJA8EWtPUbI5t1CR2Y	false	fc-igg tag:c-c|his tag:c-c|sufficient binding region:35-242	sufficient binding region:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)