#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P02666	uniprotkb:P0C0V0	intact:EBI-5260183|uniprotkb:A1YQZ8|uniprotkb:A6N8V0|uniprotkb:Q2TA13|uniprotkb:Q5EEQ6|uniprotkb:Q5EEQ7|uniprotkb:Q6UN63|uniprotkb:Q9BDG5|uniprotkb:Q9TSD5	intact:EBI-547165|uniprotkb:P09376|uniprotkb:P15724|ensemblbacteria:AAC73272|ensemblbacteria:BAB96738	psi-mi:casb_bovin(display_long)|uniprotkb:CSN2(gene name)|psi-mi:CSN2(display_short)	psi-mi:degp_ecoli(display_long)|uniprotkb:degP(gene name)|psi-mi:degP(display_short)|uniprotkb:htrA(gene name synonym)|uniprotkb:ptd(gene name synonym)|uniprotkb:b0161(locus name)|uniprotkb:JW0157(locus name)|uniprotkb:Heat shock protein DegP(gene name synonym)|uniprotkb:Protease Do(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Merdanovic et al. (2010)	pubmed:20581826|doi:10.1038/nsmb.1839|imex:IM-16066	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0465"(DIP)	intact:EBI-15862218|imex:IM-16066-1|dip:DIP-88170E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-46257N|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009408"(response to heat)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1903488"(negative regulation of lactation)|go:"GO:1903494"(response to dehydroepiandrosterone)|go:"GO:1903496"(response to 11-deoxycorticosterone)|go:"GO:1903720"(negative regulation of I-kappaB phosphorylation)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|interpro:IPR001588(Casein, alpha/beta)|interpro:IPR016345(Casein, beta)|interpro:IPR031305	refseq:NP_414703.1|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0009266"(response to temperature stimulus)|go:"GO:0009408"(response to heat)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|refseq:WP_000753946.1|interpro:IPR011782(Peptidase S1C, Do)|interpro:IPR036034|rcsb pdb:1KY9|rcsb pdb:2ZLE|rcsb pdb:3CS0|rcsb pdb:3MH4|rcsb pdb:3MH5|rcsb pdb:3MH6|rcsb pdb:3MH7|rcsb pdb:3OTP|rcsb pdb:3OU0|rcsb pdb:4A8D|rcsb pdb:6JJK|rcsb pdb:6JJL|rcsb pdb:6JJO|ensemblbacteria:AAC73272(transcript)|ensemblbacteria:b0161(gene)|ensemblbacteria:BAB96738(gene)|ensemblbacteria:BAB96738(transcript)|dip:DIP-46256N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:wtuOGN4l9NtBjB0YyHhilo7usl49913	rogid:k/rUQYeabYOrdjpk8ZmRgr38Y5A83333	rigid:JAlZsCNkvdA/jce04n9RE8XMyEc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-15862251	uniprotkb:P0C0V0	dip:DIP-59055N	intact:EBI-547165|uniprotkb:P09376|uniprotkb:P15724|ensemblbacteria:AAC73272|ensemblbacteria:BAB96738	psi-mi:dnrdgnvyff(display_short)|psi-mi:EBI-15862251(display_long)	psi-mi:degp_ecoli(display_long)|uniprotkb:degP(gene name)|psi-mi:degP(display_short)|uniprotkb:htrA(gene name synonym)|uniprotkb:ptd(gene name synonym)|uniprotkb:b0161(locus name)|uniprotkb:JW0157(locus name)|uniprotkb:Heat shock protein DegP(gene name synonym)|uniprotkb:Protease Do(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Merdanovic et al. (2010)	pubmed:20581826|doi:10.1038/nsmb.1839|imex:IM-16066	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15862254|imex:IM-16066-3|dip:DIP-186918E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_414703.1|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0009266"(response to temperature stimulus)|go:"GO:0009408"(response to heat)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|refseq:WP_000753946.1|interpro:IPR011782(Peptidase S1C, Do)|interpro:IPR036034|rcsb pdb:1KY9|rcsb pdb:2ZLE|rcsb pdb:3CS0|rcsb pdb:3MH4|rcsb pdb:3MH5|rcsb pdb:3MH6|rcsb pdb:3MH7|rcsb pdb:3OTP|rcsb pdb:3OU0|rcsb pdb:4A8D|rcsb pdb:6JJK|rcsb pdb:6JJL|rcsb pdb:6JJO|ensemblbacteria:AAC73272(transcript)|ensemblbacteria:b0161(gene)|ensemblbacteria:BAB96738(gene)|ensemblbacteria:BAB96738(transcript)|dip:DIP-46256N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:qDPHvoR9HTvtqMsUHCy+usCdH6Y-2	rogid:k/rUQYeabYOrdjpk8ZmRgr38Y5A83333	rigid:/LDSKeX/uAkeA3dKz7shrLkeZEw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-15862271	uniprotkb:P0C0V0	dip:DIP-59054N	intact:EBI-547165|uniprotkb:P09376|uniprotkb:P15724|ensemblbacteria:AAC73272|ensemblbacteria:BAB96738	psi-mi:dpmfklv(display_short)|psi-mi:EBI-15862271(display_long)	psi-mi:degp_ecoli(display_long)|uniprotkb:degP(gene name)|psi-mi:degP(display_short)|uniprotkb:htrA(gene name synonym)|uniprotkb:ptd(gene name synonym)|uniprotkb:b0161(locus name)|uniprotkb:JW0157(locus name)|uniprotkb:Heat shock protein DegP(gene name synonym)|uniprotkb:Protease Do(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Merdanovic et al. (2010)	pubmed:20581826|doi:10.1038/nsmb.1839|imex:IM-16066	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15862274|imex:IM-16066-4|dip:DIP-186919E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_414703.1|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0009266"(response to temperature stimulus)|go:"GO:0009408"(response to heat)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|refseq:WP_000753946.1|interpro:IPR011782(Peptidase S1C, Do)|interpro:IPR036034|rcsb pdb:1KY9|rcsb pdb:2ZLE|rcsb pdb:3CS0|rcsb pdb:3MH4|rcsb pdb:3MH5|rcsb pdb:3MH6|rcsb pdb:3MH7|rcsb pdb:3OTP|rcsb pdb:3OU0|rcsb pdb:4A8D|rcsb pdb:6JJK|rcsb pdb:6JJL|rcsb pdb:6JJO|ensemblbacteria:AAC73272(transcript)|ensemblbacteria:b0161(gene)|ensemblbacteria:BAB96738(gene)|ensemblbacteria:BAB96738(transcript)|dip:DIP-46256N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:QM0snVeK1h0KyktyUjNS38Rs7FY-2	rogid:k/rUQYeabYOrdjpk8ZmRgr38Y5A83333	rigid:1iLMNK/u2ZmXpatDB9i1GHidI+k	false	-	mutation disrupting interaction:266-266|mutation disrupting interaction:354-354,288-288|mutation disrupting interaction:222-222|mutation disrupting interaction:224-224	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-15862251	uniprotkb:P0C0V0	dip:DIP-59055N	intact:EBI-547165|uniprotkb:P09376|uniprotkb:P15724|ensemblbacteria:AAC73272|ensemblbacteria:BAB96738	psi-mi:dnrdgnvyff(display_short)|psi-mi:EBI-15862251(display_long)	psi-mi:degp_ecoli(display_long)|uniprotkb:degP(gene name)|psi-mi:degP(display_short)|uniprotkb:htrA(gene name synonym)|uniprotkb:ptd(gene name synonym)|uniprotkb:b0161(locus name)|uniprotkb:JW0157(locus name)|uniprotkb:Heat shock protein DegP(gene name synonym)|uniprotkb:Protease Do(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Merdanovic et al. (2010)	pubmed:20581826|doi:10.1038/nsmb.1839|imex:IM-16066	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15862304|imex:IM-16066-5|dip:DIP-186918E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_414703.1|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0009266"(response to temperature stimulus)|go:"GO:0009408"(response to heat)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|refseq:WP_000753946.1|interpro:IPR011782(Peptidase S1C, Do)|interpro:IPR036034|rcsb pdb:1KY9|rcsb pdb:2ZLE|rcsb pdb:3CS0|rcsb pdb:3MH4|rcsb pdb:3MH5|rcsb pdb:3MH6|rcsb pdb:3MH7|rcsb pdb:3OTP|rcsb pdb:3OU0|rcsb pdb:4A8D|rcsb pdb:6JJK|rcsb pdb:6JJL|rcsb pdb:6JJO|ensemblbacteria:AAC73272(transcript)|ensemblbacteria:b0161(gene)|ensemblbacteria:BAB96738(gene)|ensemblbacteria:BAB96738(transcript)|dip:DIP-46256N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:qDPHvoR9HTvtqMsUHCy+usCdH6Y-2	rogid:k/rUQYeabYOrdjpk8ZmRgr38Y5A83333	rigid:/LDSKeX/uAkeA3dKz7shrLkeZEw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-15862271	uniprotkb:P0C0V0	dip:DIP-59054N	intact:EBI-547165|uniprotkb:P09376|uniprotkb:P15724|ensemblbacteria:AAC73272|ensemblbacteria:BAB96738	psi-mi:dpmfklv(display_short)|psi-mi:EBI-15862271(display_long)	psi-mi:degp_ecoli(display_long)|uniprotkb:degP(gene name)|psi-mi:degP(display_short)|uniprotkb:htrA(gene name synonym)|uniprotkb:ptd(gene name synonym)|uniprotkb:b0161(locus name)|uniprotkb:JW0157(locus name)|uniprotkb:Heat shock protein DegP(gene name synonym)|uniprotkb:Protease Do(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Merdanovic et al. (2010)	pubmed:20581826|doi:10.1038/nsmb.1839|imex:IM-16066	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15862321|imex:IM-16066-6|dip:DIP-186919E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_414703.1|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0009266"(response to temperature stimulus)|go:"GO:0009408"(response to heat)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|refseq:WP_000753946.1|interpro:IPR011782(Peptidase S1C, Do)|interpro:IPR036034|rcsb pdb:1KY9|rcsb pdb:2ZLE|rcsb pdb:3CS0|rcsb pdb:3MH4|rcsb pdb:3MH5|rcsb pdb:3MH6|rcsb pdb:3MH7|rcsb pdb:3OTP|rcsb pdb:3OU0|rcsb pdb:4A8D|rcsb pdb:6JJK|rcsb pdb:6JJL|rcsb pdb:6JJO|ensemblbacteria:AAC73272(transcript)|ensemblbacteria:b0161(gene)|ensemblbacteria:BAB96738(gene)|ensemblbacteria:BAB96738(transcript)|dip:DIP-46256N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:QM0snVeK1h0KyktyUjNS38Rs7FY-2	rogid:k/rUQYeabYOrdjpk8ZmRgr38Y5A83333	rigid:1iLMNK/u2ZmXpatDB9i1GHidI+k	false	-	mutation disrupting interaction:288-288|mutation disrupting interaction:354-354|mutation disrupting interaction:354-354,288-288|mutation disrupting interaction:291-291|mutation disrupting interaction:350-350|mutation decreasing interaction:213-213|mutation decreasing interaction:216-216|mutation decreasing interaction:222-222|mutation decreasing interaction:224-224|mutation decreasing interaction:255-255|mutation decreasing interaction:264-264|mutation decreasing interaction:266-266	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02666	uniprotkb:P0C0V0	intact:EBI-5260183|uniprotkb:A1YQZ8|uniprotkb:A6N8V0|uniprotkb:Q2TA13|uniprotkb:Q5EEQ6|uniprotkb:Q5EEQ7|uniprotkb:Q6UN63|uniprotkb:Q9BDG5|uniprotkb:Q9TSD5	intact:EBI-547165|uniprotkb:P09376|uniprotkb:P15724|ensemblbacteria:AAC73272|ensemblbacteria:BAB96738	psi-mi:casb_bovin(display_long)|uniprotkb:CSN2(gene name)|psi-mi:CSN2(display_short)	psi-mi:degp_ecoli(display_long)|uniprotkb:degP(gene name)|psi-mi:degP(display_short)|uniprotkb:htrA(gene name synonym)|uniprotkb:ptd(gene name synonym)|uniprotkb:b0161(locus name)|uniprotkb:JW0157(locus name)|uniprotkb:Heat shock protein DegP(gene name synonym)|uniprotkb:Protease Do(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Merdanovic et al. (2010)	pubmed:20581826|doi:10.1038/nsmb.1839|imex:IM-16066	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15862375|imex:IM-16066-7|dip:DIP-88170E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-46257N|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009408"(response to heat)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1903488"(negative regulation of lactation)|go:"GO:1903494"(response to dehydroepiandrosterone)|go:"GO:1903496"(response to 11-deoxycorticosterone)|go:"GO:1903720"(negative regulation of I-kappaB phosphorylation)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|interpro:IPR001588(Casein, alpha/beta)|interpro:IPR016345(Casein, beta)|interpro:IPR031305	refseq:NP_414703.1|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0009266"(response to temperature stimulus)|go:"GO:0009408"(response to heat)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|refseq:WP_000753946.1|interpro:IPR011782(Peptidase S1C, Do)|interpro:IPR036034|rcsb pdb:1KY9|rcsb pdb:2ZLE|rcsb pdb:3CS0|rcsb pdb:3MH4|rcsb pdb:3MH5|rcsb pdb:3MH6|rcsb pdb:3MH7|rcsb pdb:3OTP|rcsb pdb:3OU0|rcsb pdb:4A8D|rcsb pdb:6JJK|rcsb pdb:6JJL|rcsb pdb:6JJO|ensemblbacteria:AAC73272(transcript)|ensemblbacteria:b0161(gene)|ensemblbacteria:BAB96738(gene)|ensemblbacteria:BAB96738(transcript)|dip:DIP-46256N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:wtuOGN4l9NtBjB0YyHhilo7usl49913	rogid:k/rUQYeabYOrdjpk8ZmRgr38Y5A83333	rigid:JAlZsCNkvdA/jce04n9RE8XMyEc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0V0	uniprotkb:P0C0V0	intact:EBI-547165|uniprotkb:P09376|uniprotkb:P15724|ensemblbacteria:AAC73272|ensemblbacteria:BAB96738	intact:EBI-547165|uniprotkb:P09376|uniprotkb:P15724|ensemblbacteria:AAC73272|ensemblbacteria:BAB96738	psi-mi:degp_ecoli(display_long)|uniprotkb:degP(gene name)|psi-mi:degP(display_short)|uniprotkb:htrA(gene name synonym)|uniprotkb:ptd(gene name synonym)|uniprotkb:b0161(locus name)|uniprotkb:JW0157(locus name)|uniprotkb:Heat shock protein DegP(gene name synonym)|uniprotkb:Protease Do(gene name synonym)	psi-mi:degp_ecoli(display_long)|uniprotkb:degP(gene name)|psi-mi:degP(display_short)|uniprotkb:htrA(gene name synonym)|uniprotkb:ptd(gene name synonym)|uniprotkb:b0161(locus name)|uniprotkb:JW0157(locus name)|uniprotkb:Heat shock protein DegP(gene name synonym)|uniprotkb:Protease Do(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Merdanovic et al. (2010)	pubmed:20581826|doi:10.1038/nsmb.1839|imex:IM-16066	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15862235|imex:IM-16066-2|dip:DIP-88172E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_414703.1|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0009266"(response to temperature stimulus)|go:"GO:0009408"(response to heat)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|refseq:WP_000753946.1|interpro:IPR011782(Peptidase S1C, Do)|interpro:IPR036034|rcsb pdb:1KY9|rcsb pdb:2ZLE|rcsb pdb:3CS0|rcsb pdb:3MH4|rcsb pdb:3MH5|rcsb pdb:3MH6|rcsb pdb:3MH7|rcsb pdb:3OTP|rcsb pdb:3OU0|rcsb pdb:4A8D|rcsb pdb:6JJK|rcsb pdb:6JJL|rcsb pdb:6JJO|ensemblbacteria:AAC73272(transcript)|ensemblbacteria:b0161(gene)|ensemblbacteria:BAB96738(gene)|ensemblbacteria:BAB96738(transcript)|dip:DIP-46256N	refseq:NP_414703.1|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0009266"(response to temperature stimulus)|go:"GO:0009408"(response to heat)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|refseq:WP_000753946.1|interpro:IPR011782(Peptidase S1C, Do)|interpro:IPR036034|rcsb pdb:1KY9|rcsb pdb:2ZLE|rcsb pdb:3CS0|rcsb pdb:3MH4|rcsb pdb:3MH5|rcsb pdb:3MH6|rcsb pdb:3MH7|rcsb pdb:3OTP|rcsb pdb:3OU0|rcsb pdb:4A8D|rcsb pdb:6JJK|rcsb pdb:6JJL|rcsb pdb:6JJO|ensemblbacteria:AAC73272(transcript)|ensemblbacteria:b0161(gene)|ensemblbacteria:BAB96738(gene)|ensemblbacteria:BAB96738(transcript)|dip:DIP-46256N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:k/rUQYeabYOrdjpk8ZmRgr38Y5A83333	rogid:k/rUQYeabYOrdjpk8ZmRgr38Y5A83333	rigid:x4HZ8clWaBGiKBibzuXlojAChBg	false	-	-	-	0	psi-mi:"MI:0817"(molecular weight estimation by silver staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)
uniprotkb:P02666	uniprotkb:P0C0V0	intact:EBI-5260183|uniprotkb:A1YQZ8|uniprotkb:A6N8V0|uniprotkb:Q2TA13|uniprotkb:Q5EEQ6|uniprotkb:Q5EEQ7|uniprotkb:Q6UN63|uniprotkb:Q9BDG5|uniprotkb:Q9TSD5	intact:EBI-547165|uniprotkb:P09376|uniprotkb:P15724|ensemblbacteria:AAC73272|ensemblbacteria:BAB96738	psi-mi:casb_bovin(display_long)|uniprotkb:CSN2(gene name)|psi-mi:CSN2(display_short)	psi-mi:degp_ecoli(display_long)|uniprotkb:degP(gene name)|psi-mi:degP(display_short)|uniprotkb:htrA(gene name synonym)|uniprotkb:ptd(gene name synonym)|uniprotkb:b0161(locus name)|uniprotkb:JW0157(locus name)|uniprotkb:Heat shock protein DegP(gene name synonym)|uniprotkb:Protease Do(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Merdanovic et al. (2010)	pubmed:20581826|doi:10.1038/nsmb.1839|imex:IM-16066	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15862392|imex:IM-16066-8|dip:DIP-88170E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-46257N|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009408"(response to heat)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1903488"(negative regulation of lactation)|go:"GO:1903494"(response to dehydroepiandrosterone)|go:"GO:1903496"(response to 11-deoxycorticosterone)|go:"GO:1903720"(negative regulation of I-kappaB phosphorylation)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|interpro:IPR001588(Casein, alpha/beta)|interpro:IPR016345(Casein, beta)|interpro:IPR031305	refseq:NP_414703.1|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0009266"(response to temperature stimulus)|go:"GO:0009408"(response to heat)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|refseq:WP_000753946.1|interpro:IPR011782(Peptidase S1C, Do)|interpro:IPR036034|rcsb pdb:1KY9|rcsb pdb:2ZLE|rcsb pdb:3CS0|rcsb pdb:3MH4|rcsb pdb:3MH5|rcsb pdb:3MH6|rcsb pdb:3MH7|rcsb pdb:3OTP|rcsb pdb:3OU0|rcsb pdb:4A8D|rcsb pdb:6JJK|rcsb pdb:6JJL|rcsb pdb:6JJO|ensemblbacteria:AAC73272(transcript)|ensemblbacteria:b0161(gene)|ensemblbacteria:BAB96738(gene)|ensemblbacteria:BAB96738(transcript)|dip:DIP-46256N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:wtuOGN4l9NtBjB0YyHhilo7usl49913	rogid:k/rUQYeabYOrdjpk8ZmRgr38Y5A83333	rigid:JAlZsCNkvdA/jce04n9RE8XMyEc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)