#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q15788 uniprotkb:P10276 intact:EBI-455189|uniprotkb:O00150|uniprotkb:O43792|uniprotkb:O43793|uniprotkb:Q13071|uniprotkb:Q13420|uniprotkb:Q2T9G5|uniprotkb:Q53SX3|uniprotkb:Q6GVI5|uniprotkb:Q7KYV3|ensembl:ENSP00000320940|ensembl:ENSP00000385216 intact:EBI-413374|uniprotkb:P78456|uniprotkb:Q13440|uniprotkb:Q13441|uniprotkb:Q96S41|uniprotkb:Q9NQS0|uniprotkb:B8Y636|ensembl:ENSP00000254066|ensembl:ENSP00000377649 psi-mi:ncoa1_human(display_long)|uniprotkb:Steroid receptor coactivator 1(gene name synonym)|uniprotkb:RIP160(gene name synonym)|uniprotkb:Protein Hin-2(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-52(gene name synonym)|uniprotkb:NCOA1(gene name)|psi-mi:NCOA1(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:BHLHE74(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 74(gene name synonym) psi-mi:rara_human(display_long)|uniprotkb:RARA(gene name)|psi-mi:RARA(display_short)|uniprotkb:NR1B1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group B member 1(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) le et al. (2010) pubmed:20543827|doi:10.1038/nsmb.1855|imex:IM-15985 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15860502|imex:IM-15985-2|dip:DIP-72877E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_671756.1|refseq:NP_671766.1|refseq:NP_003734.3|ensembl:ENSP00000379197|ensembl:ENST00000405141|ensembl:ENSP00000385097|ensembl:ENSP00000385216|ensembl:ENSP00000320940|ensembl:ENST00000395856|ensembl:ENST00000288599|ensembl:ENSP00000288599|refseq:XP_005264682.1|refseq:XP_005264683.1|refseq:XP_005264685.1|refseq:XP_016860657.1|refseq:XP_016860658.1|dip:DIP-30877N|ensembl:ENSG00000084676(gene)|ensembl:ENST00000348332(transcript)|ensembl:ENST00000406961(transcript)|go:"GO:0000435"(positive regulation of transcription from RNA polymerase II promoter by galactose)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007595"(lactation)|go:"GO:0008584"(male gonad development)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021854"(hypothalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045925"(positive regulation of female receptivity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060179"(male mating behavior)|go:"GO:0060713"(labyrinthine layer morphogenesis)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|go:"GO:2001038"(regulation of cellular response to drug)|interpro:IPR000014(PAS)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010011(Protein of unknown function DUF1518)|rcsb pdb:2NV7|rcsb pdb:2P54|rcsb pdb:2PRG|rcsb pdb:3BEJ|rcsb pdb:3BQD|rcsb pdb:3CTB|rcsb pdb:3CWD|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3DR1|rcsb pdb:3ET1|rcsb pdb:3ET3|rcsb pdb:3FEI|rcsb pdb:3FEJ|rcsb pdb:3FUR|rcsb pdb:3FXV|rcsb pdb:3G8I|rcsb pdb:3G9E|rcsb pdb:3GYT|rcsb pdb:3GYU|rcsb pdb:3H0A|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3HVL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:3KMR|rcsb pdb:3LMP|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OLL|rcsb pdb:3OLS|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OMO|rcsb pdb:3OMP|rcsb pdb:3OMQ|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3QT0|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:3S9S|rcsb pdb:3T03|rcsb pdb:3UU7|rcsb pdb:3UUA|rcsb pdb:3UUD|rcsb pdb:3V9Y|rcsb pdb:3VN2|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4DM6|rcsb pdb:4DM8|interpro:IPR013767(PAS fold)|interpro:IPR014920(Nuclear receptor coactivator, Ncoa-type, interlocking)|interpro:IPR014935(Steroid receptor coactivator)|interpro:IPR017426(Nuclear receptor coactivator)|interpro:IPR028819|interpro:IPR035965|interpro:IPR036638|interpro:IPR037077|mint:Q15788|rcsb pdb:1FM6|rcsb pdb:1FM9|rcsb pdb:1K4W|rcsb pdb:1K74|rcsb pdb:1K7L|rcsb pdb:1KV6|rcsb pdb:1N4H|rcsb pdb:1NQ7|rcsb pdb:1NRL|rcsb pdb:1P8D|rcsb pdb:1PZL|rcsb pdb:1RDT|rcsb pdb:1TFC|rcsb pdb:1U3R|rcsb pdb:1U3S|rcsb pdb:1X76|rcsb pdb:1X78|rcsb pdb:1X7B|rcsb pdb:1X7J|rcsb pdb:1XIU|rcsb pdb:1XV9|rcsb pdb:1XVP|rcsb pdb:1YY4|rcsb pdb:1YYE|rcsb pdb:1ZAF|rcsb pdb:2A3I|rcsb pdb:2C52|rcsb pdb:2FVJ|rcsb pdb:2GTK|rcsb pdb:2HBH|rcsb pdb:2HC4|rcsb pdb:2HCD|rcsb pdb:2HFP|rcsb pdb:2NPA|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5DV6|rcsb pdb:5DV8|rcsb pdb:5DVC|rcsb pdb:5DWL|rcsb pdb:5E7V|rcsb pdb:5GTN|rcsb pdb:5GTO|rcsb pdb:5GTP|rcsb pdb:5HJS|rcsb pdb:5JI0|rcsb pdb:5JMM|rcsb pdb:5L7E|rcsb pdb:5L7G|rcsb pdb:5L7H|rcsb pdb:5MWP|rcsb pdb:5MWY|rcsb pdb:5MX7|rcsb pdb:5NKY|rcsb pdb:5NMA|rcsb pdb:5NMB|rcsb pdb:5NWM|rcsb pdb:5OW7|rcsb pdb:5OW9|rcsb pdb:5OWD|rcsb pdb:4G1Z|rcsb pdb:4G20|rcsb pdb:4G21|rcsb pdb:4G2H|rcsb pdb:4HEE|rcsb pdb:4J5X|rcsb pdb:4JYG|rcsb pdb:4JYH|rcsb pdb:4JYI|rcsb pdb:4MG5|rcsb pdb:4MG6|rcsb pdb:4MG7|rcsb pdb:4DQM|rcsb pdb:4MG8|rcsb pdb:4MG9|rcsb pdb:4MGA|rcsb pdb:4MGB|rcsb pdb:4MGC|rcsb pdb:4MGD|rcsb pdb:4RUJ|rcsb pdb:4RUP|rcsb pdb:4TUZ|rcsb pdb:4TV1|rcsb pdb:4UDA|rcsb pdb:4UDB|rcsb pdb:4Y29|rcsb pdb:5A86|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:4F9M|rcsb pdb:4FGY|rcsb pdb:4G1D|rcsb pdb:4G1Y|rcsb pdb:5AZT|rcsb pdb:5DSH|rcsb pdb:5DV3|rcsb pdb:6L96|rcsb pdb:6NX1|rcsb pdb:6P9F|rcsb pdb:6SSQ|rcsb pdb:6T2M|rcsb pdb:6TFI|rcsb pdb:6U25|rcsb pdb:6W9H|rcsb pdb:6W9I|rcsb pdb:6XP9|rcsb pdb:7BPY|rcsb pdb:7BPZ|rcsb pdb:7BQ0|rcsb pdb:7BQ1|rcsb pdb:7BQ2|rcsb pdb:7BQ3|rcsb pdb:7BQ4|rcsb pdb:7JYM|rcsb pdb:7KXD|rcsb pdb:7KXE|rcsb pdb:7KXF|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-159418|reactome:R-HSA-192105|reactome:R-HSA-193368|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-193807|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-3214847|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-9018519|reactome:R-HSA-9029569|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6BNS|rcsb pdb:6E3G|rcsb pdb:6FO7|rcsb pdb:6FO8|rcsb pdb:6FO9|rcsb pdb:6FOB|rcsb pdb:6FOD|rcsb pdb:6GEV|rcsb pdb:6GG8|rcsb pdb:5Q1D|rcsb pdb:6HTY|rcsb pdb:6ICJ|rcsb pdb:5Q1E|rcsb pdb:6IJR|rcsb pdb:6IJS|rcsb pdb:6ILQ|rcsb pdb:6ITM|rcsb pdb:6JNR|rcsb pdb:6JQ7|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5X0R|rcsb pdb:5X8U|rcsb pdb:5X8W|rcsb pdb:5Y44|rcsb pdb:5YCN|rcsb pdb:5YCP|rcsb pdb:5YP6|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6KTM|rcsb pdb:6KTN|rcsb pdb:6L6K|interpro:IPR011598(Helix-loop-helix DNA-binding) refseq:NP_000955.1|refseq:NP_001019980.1|refseq:NP_001138773.1|refseq:XP_011523397.1|refseq:NP_001138774.1|refseq:XP_005257610.1|refseq:XP_005257611.1|ensembl:ENSG00000131759(gene)|ensembl:ENST00000254066(transcript)|ensembl:ENST00000394089(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001889"(liver development)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0002068"(glandular epithelial cell development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030850"(prostate gland development)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0034097"(response to cytokine)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044323"(retinoic acid-responsive element binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060010"(Sertoli cell fate commitment)|go:"GO:0060173"(limb development)|go:"GO:0060324"(face development)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0061037"(negative regulation of cartilage development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10276|rcsb pdb:1DKF|rcsb pdb:1DSZ|rcsb pdb:3A9E|rcsb pdb:3KMR|rcsb pdb:3KMZ|rcsb pdb:4DQM|rcsb pdb:5K13|rcsb pdb:6XWG|reactome:R-HSA-4090294|reactome:R-HSA-5362517|reactome:R-HSA-5617472|reactome:R-HSA-9616222|reactome:R-HSA-383280|dip:DIP-34N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:OKjGLyCEDCW1kgUe6qB9bnKO4Rs9606 rogid:hxW9W0aqa3qEJT5ZilJdJ4b+gEo9606 rigid:VAya5kpJqPVu9we7YVD/0hP4K08 false binding-associated region:686-698 binding-associated region:176-421 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75376 uniprotkb:P10276 intact:EBI-347233|uniprotkb:E9PGV6|uniprotkb:Q86YY0|uniprotkb:Q9UPV5|uniprotkb:Q9UQ18|intact:EBI-28976482|ensembl:ENSP00000268712|uniprotkb:B3DLF8 intact:EBI-413374|uniprotkb:P78456|uniprotkb:Q13440|uniprotkb:Q13441|uniprotkb:Q96S41|uniprotkb:Q9NQS0|uniprotkb:B8Y636|ensembl:ENSP00000254066|ensembl:ENSP00000377649 psi-mi:ncor1_human(display_long)|uniprotkb:NCOR1(gene name)|psi-mi:NCOR1(display_short)|uniprotkb:KIAA1047(gene name synonym) psi-mi:rara_human(display_long)|uniprotkb:RARA(gene name)|psi-mi:RARA(display_short)|uniprotkb:NR1B1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group B member 1(gene name synonym) psi-mi:"MI:0017"(classical fluorescence spectroscopy) le et al. (2010) pubmed:20543827|doi:10.1038/nsmb.1855|imex:IM-15985 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15860473|imex:IM-15985-1|dip:DIP-186532E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29402N|ensembl:ENSP00000268712|ensembl:ENST00000395848|ensembl:ENSP00000379189|ensembl:ENST00000395851|ensembl:ENSP00000379192|ensembl:ENSG00000141027(gene)|ensembl:ENST00000268712(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0016020"(membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:O75376|rcsb pdb:2EQR|rcsb pdb:3KMZ|rcsb pdb:3N00|rcsb pdb:4MDD|rcsb pdb:4WVD|rcsb pdb:6ONI|rcsb pdb:6WMQ|rcsb pdb:6XXS|rcsb pdb:6XYX|rcsb pdb:6XZZ|rcsb pdb:6Y17|rcsb pdb:6ZBU|reactome:R-HSA-1251985|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2173795|reactome:R-HSA-2644606|rcsb pdb:3H52|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|refseq:XP_011522388.1|refseq:NP_001177369.1|refseq:NP_006302.2|refseq:NP_001177367.1 refseq:NP_000955.1|refseq:NP_001019980.1|refseq:NP_001138773.1|refseq:XP_011523397.1|refseq:NP_001138774.1|refseq:XP_005257610.1|refseq:XP_005257611.1|ensembl:ENSG00000131759(gene)|ensembl:ENST00000254066(transcript)|ensembl:ENST00000394089(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001889"(liver development)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0002068"(glandular epithelial cell development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030850"(prostate gland development)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0034097"(response to cytokine)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044323"(retinoic acid-responsive element binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060010"(Sertoli cell fate commitment)|go:"GO:0060173"(limb development)|go:"GO:0060324"(face development)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0061037"(negative regulation of cartilage development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10276|rcsb pdb:1DKF|rcsb pdb:1DSZ|rcsb pdb:3A9E|rcsb pdb:3KMR|rcsb pdb:3KMZ|rcsb pdb:4DQM|rcsb pdb:5K13|rcsb pdb:6XWG|reactome:R-HSA-4090294|reactome:R-HSA-5362517|reactome:R-HSA-5617472|reactome:R-HSA-9616222|reactome:R-HSA-383280|dip:DIP-34N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:8W82xLRBbuJwVpXSvxoGQBu0v7Y9606 rogid:hxW9W0aqa3qEJT5ZilJdJ4b+gEo9606 rigid:yhJzD1t9YwaUpsJQgvCLeyofgF0 false binding-associated region:2047-2065|binding-associated region:2256-2276|fluorescein label:n-n binding-associated region:176-421|mutation decreasing interaction:396-396 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q60974 uniprotkb:P10276 intact:EBI-349004|uniprotkb:Q60812 intact:EBI-413374|uniprotkb:P78456|uniprotkb:Q13440|uniprotkb:Q13441|uniprotkb:Q96S41|uniprotkb:Q9NQS0|uniprotkb:B8Y636|ensembl:ENSP00000254066|ensembl:ENSP00000377649 psi-mi:ncor1_mouse(display_long)|uniprotkb:Ncor1(gene name)|psi-mi:Ncor1(display_short)|uniprotkb:Rxrip13(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 13(gene name synonym) psi-mi:rara_human(display_long)|uniprotkb:RARA(gene name)|psi-mi:RARA(display_short)|uniprotkb:NR1B1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group B member 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) le et al. (2010) pubmed:20543827|doi:10.1038/nsmb.1855|imex:IM-15985 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15860523|imex:IM-15985-3|dip:DIP-186533E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0002361"(CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021794"(thalamus development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051225"(spindle assembly)|go:"GO:0060318"(definitive erythrocyte differentiation)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|go:"GO:0046329"(negative regulation of JNK cascade)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|reactome:R-MMU-2173795|reactome:R-MMU-3214815|reactome:R-MMU-350054|go:"GO:0046965"(retinoid X receptor binding)|reactome:R-MMU-383280|reactome:R-MMU-9029569|reactome:R-MMU-9623433|reactome:R-MMU-9707564|reactome:R-MMU-400206|mint:Q60974|dip:DIP-32548N refseq:NP_000955.1|refseq:NP_001019980.1|refseq:NP_001138773.1|refseq:XP_011523397.1|refseq:NP_001138774.1|refseq:XP_005257610.1|refseq:XP_005257611.1|ensembl:ENSG00000131759(gene)|ensembl:ENST00000254066(transcript)|ensembl:ENST00000394089(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001889"(liver development)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0002068"(glandular epithelial cell development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030850"(prostate gland development)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0034097"(response to cytokine)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044323"(retinoic acid-responsive element binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060010"(Sertoli cell fate commitment)|go:"GO:0060173"(limb development)|go:"GO:0060324"(face development)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0061037"(negative regulation of cartilage development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10276|rcsb pdb:1DKF|rcsb pdb:1DSZ|rcsb pdb:3A9E|rcsb pdb:3KMR|rcsb pdb:3KMZ|rcsb pdb:4DQM|rcsb pdb:5K13|rcsb pdb:6XWG|reactome:R-HSA-4090294|reactome:R-HSA-5362517|reactome:R-HSA-5617472|reactome:R-HSA-9616222|reactome:R-HSA-383280|dip:DIP-34N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:5IfmxD5K9s0dYCZ6AOMwaBDElFs10090 rogid:hxW9W0aqa3qEJT5ZilJdJ4b+gEo9606 rigid:kMkN8zMN8t5/5lKXs9DSDtcpLWY false binding-associated region:1629-2453 sufficient binding region:176-403|mutation disrupting interaction:396-396 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15788 uniprotkb:P10276 intact:EBI-455189|uniprotkb:O00150|uniprotkb:O43792|uniprotkb:O43793|uniprotkb:Q13071|uniprotkb:Q13420|uniprotkb:Q2T9G5|uniprotkb:Q53SX3|uniprotkb:Q6GVI5|uniprotkb:Q7KYV3|ensembl:ENSP00000320940|ensembl:ENSP00000385216 intact:EBI-413374|uniprotkb:P78456|uniprotkb:Q13440|uniprotkb:Q13441|uniprotkb:Q96S41|uniprotkb:Q9NQS0|uniprotkb:B8Y636|ensembl:ENSP00000254066|ensembl:ENSP00000377649 psi-mi:ncoa1_human(display_long)|uniprotkb:Steroid receptor coactivator 1(gene name synonym)|uniprotkb:RIP160(gene name synonym)|uniprotkb:Protein Hin-2(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-52(gene name synonym)|uniprotkb:NCOA1(gene name)|psi-mi:NCOA1(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:BHLHE74(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 74(gene name synonym) psi-mi:rara_human(display_long)|uniprotkb:RARA(gene name)|psi-mi:RARA(display_short)|uniprotkb:NR1B1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group B member 1(gene name synonym) psi-mi:"MI:0017"(classical fluorescence spectroscopy) le et al. (2010) pubmed:20543827|doi:10.1038/nsmb.1855|imex:IM-15985 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15860636|imex:IM-15985-7|dip:DIP-72877E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_671756.1|refseq:NP_671766.1|refseq:NP_003734.3|ensembl:ENSP00000379197|ensembl:ENST00000405141|ensembl:ENSP00000385097|ensembl:ENSP00000385216|ensembl:ENSP00000320940|ensembl:ENST00000395856|ensembl:ENST00000288599|ensembl:ENSP00000288599|refseq:XP_005264682.1|refseq:XP_005264683.1|refseq:XP_005264685.1|refseq:XP_016860657.1|refseq:XP_016860658.1|dip:DIP-30877N|ensembl:ENSG00000084676(gene)|ensembl:ENST00000348332(transcript)|ensembl:ENST00000406961(transcript)|go:"GO:0000435"(positive regulation of transcription from RNA polymerase II promoter by galactose)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007595"(lactation)|go:"GO:0008584"(male gonad development)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021854"(hypothalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045925"(positive regulation of female receptivity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060179"(male mating behavior)|go:"GO:0060713"(labyrinthine layer morphogenesis)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|go:"GO:2001038"(regulation of cellular response to drug)|interpro:IPR000014(PAS)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010011(Protein of unknown function DUF1518)|rcsb pdb:2NV7|rcsb pdb:2P54|rcsb pdb:2PRG|rcsb pdb:3BEJ|rcsb pdb:3BQD|rcsb pdb:3CTB|rcsb pdb:3CWD|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3DR1|rcsb pdb:3ET1|rcsb pdb:3ET3|rcsb pdb:3FEI|rcsb pdb:3FEJ|rcsb pdb:3FUR|rcsb pdb:3FXV|rcsb pdb:3G8I|rcsb pdb:3G9E|rcsb pdb:3GYT|rcsb pdb:3GYU|rcsb pdb:3H0A|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3HVL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:3KMR|rcsb pdb:3LMP|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OLL|rcsb pdb:3OLS|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OMO|rcsb pdb:3OMP|rcsb pdb:3OMQ|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3QT0|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:3S9S|rcsb pdb:3T03|rcsb pdb:3UU7|rcsb pdb:3UUA|rcsb pdb:3UUD|rcsb pdb:3V9Y|rcsb pdb:3VN2|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4DM6|rcsb pdb:4DM8|interpro:IPR013767(PAS fold)|interpro:IPR014920(Nuclear receptor coactivator, Ncoa-type, interlocking)|interpro:IPR014935(Steroid receptor coactivator)|interpro:IPR017426(Nuclear receptor coactivator)|interpro:IPR028819|interpro:IPR035965|interpro:IPR036638|interpro:IPR037077|mint:Q15788|rcsb pdb:1FM6|rcsb pdb:1FM9|rcsb pdb:1K4W|rcsb pdb:1K74|rcsb pdb:1K7L|rcsb pdb:1KV6|rcsb pdb:1N4H|rcsb pdb:1NQ7|rcsb pdb:1NRL|rcsb pdb:1P8D|rcsb pdb:1PZL|rcsb pdb:1RDT|rcsb pdb:1TFC|rcsb pdb:1U3R|rcsb pdb:1U3S|rcsb pdb:1X76|rcsb pdb:1X78|rcsb pdb:1X7B|rcsb pdb:1X7J|rcsb pdb:1XIU|rcsb pdb:1XV9|rcsb pdb:1XVP|rcsb pdb:1YY4|rcsb pdb:1YYE|rcsb pdb:1ZAF|rcsb pdb:2A3I|rcsb pdb:2C52|rcsb pdb:2FVJ|rcsb pdb:2GTK|rcsb pdb:2HBH|rcsb pdb:2HC4|rcsb pdb:2HCD|rcsb pdb:2HFP|rcsb pdb:2NPA|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5DV6|rcsb pdb:5DV8|rcsb pdb:5DVC|rcsb pdb:5DWL|rcsb pdb:5E7V|rcsb pdb:5GTN|rcsb pdb:5GTO|rcsb pdb:5GTP|rcsb pdb:5HJS|rcsb pdb:5JI0|rcsb pdb:5JMM|rcsb pdb:5L7E|rcsb pdb:5L7G|rcsb pdb:5L7H|rcsb pdb:5MWP|rcsb pdb:5MWY|rcsb pdb:5MX7|rcsb pdb:5NKY|rcsb pdb:5NMA|rcsb pdb:5NMB|rcsb pdb:5NWM|rcsb pdb:5OW7|rcsb pdb:5OW9|rcsb pdb:5OWD|rcsb pdb:4G1Z|rcsb pdb:4G20|rcsb pdb:4G21|rcsb pdb:4G2H|rcsb pdb:4HEE|rcsb pdb:4J5X|rcsb pdb:4JYG|rcsb pdb:4JYH|rcsb pdb:4JYI|rcsb pdb:4MG5|rcsb pdb:4MG6|rcsb pdb:4MG7|rcsb pdb:4DQM|rcsb pdb:4MG8|rcsb pdb:4MG9|rcsb pdb:4MGA|rcsb pdb:4MGB|rcsb pdb:4MGC|rcsb pdb:4MGD|rcsb pdb:4RUJ|rcsb pdb:4RUP|rcsb pdb:4TUZ|rcsb pdb:4TV1|rcsb pdb:4UDA|rcsb pdb:4UDB|rcsb pdb:4Y29|rcsb pdb:5A86|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:4F9M|rcsb pdb:4FGY|rcsb pdb:4G1D|rcsb pdb:4G1Y|rcsb pdb:5AZT|rcsb pdb:5DSH|rcsb pdb:5DV3|rcsb pdb:6L96|rcsb pdb:6NX1|rcsb pdb:6P9F|rcsb pdb:6SSQ|rcsb pdb:6T2M|rcsb pdb:6TFI|rcsb pdb:6U25|rcsb pdb:6W9H|rcsb pdb:6W9I|rcsb pdb:6XP9|rcsb pdb:7BPY|rcsb pdb:7BPZ|rcsb pdb:7BQ0|rcsb pdb:7BQ1|rcsb pdb:7BQ2|rcsb pdb:7BQ3|rcsb pdb:7BQ4|rcsb pdb:7JYM|rcsb pdb:7KXD|rcsb pdb:7KXE|rcsb pdb:7KXF|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-159418|reactome:R-HSA-192105|reactome:R-HSA-193368|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-193807|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-3214847|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-9018519|reactome:R-HSA-9029569|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6BNS|rcsb pdb:6E3G|rcsb pdb:6FO7|rcsb pdb:6FO8|rcsb pdb:6FO9|rcsb pdb:6FOB|rcsb pdb:6FOD|rcsb pdb:6GEV|rcsb pdb:6GG8|rcsb pdb:5Q1D|rcsb pdb:6HTY|rcsb pdb:6ICJ|rcsb pdb:5Q1E|rcsb pdb:6IJR|rcsb pdb:6IJS|rcsb pdb:6ILQ|rcsb pdb:6ITM|rcsb pdb:6JNR|rcsb pdb:6JQ7|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5X0R|rcsb pdb:5X8U|rcsb pdb:5X8W|rcsb pdb:5Y44|rcsb pdb:5YCN|rcsb pdb:5YCP|rcsb pdb:5YP6|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6KTM|rcsb pdb:6KTN|rcsb pdb:6L6K|interpro:IPR011598(Helix-loop-helix DNA-binding) refseq:NP_000955.1|refseq:NP_001019980.1|refseq:NP_001138773.1|refseq:XP_011523397.1|refseq:NP_001138774.1|refseq:XP_005257610.1|refseq:XP_005257611.1|ensembl:ENSG00000131759(gene)|ensembl:ENST00000254066(transcript)|ensembl:ENST00000394089(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001889"(liver development)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0002068"(glandular epithelial cell development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030850"(prostate gland development)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0034097"(response to cytokine)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044323"(retinoic acid-responsive element binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060010"(Sertoli cell fate commitment)|go:"GO:0060173"(limb development)|go:"GO:0060324"(face development)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0061037"(negative regulation of cartilage development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10276|rcsb pdb:1DKF|rcsb pdb:1DSZ|rcsb pdb:3A9E|rcsb pdb:3KMR|rcsb pdb:3KMZ|rcsb pdb:4DQM|rcsb pdb:5K13|rcsb pdb:6XWG|reactome:R-HSA-4090294|reactome:R-HSA-5362517|reactome:R-HSA-5617472|reactome:R-HSA-9616222|reactome:R-HSA-383280|dip:DIP-34N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:OKjGLyCEDCW1kgUe6qB9bnKO4Rs9606 rogid:hxW9W0aqa3qEJT5ZilJdJ4b+gEo9606 rigid:VAya5kpJqPVu9we7YVD/0hP4K08 false binding-associated region:686-698|fluorescein label:n-n binding-associated region:176-421 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15596 uniprotkb:P10276 intact:EBI-81236|uniprotkb:Q14CD2|ensembl:ENSP00000399968 intact:EBI-413374|uniprotkb:P78456|uniprotkb:Q13440|uniprotkb:Q13441|uniprotkb:Q96S41|uniprotkb:Q9NQS0|uniprotkb:B8Y636|ensembl:ENSP00000254066|ensembl:ENSP00000377649 psi-mi:ncoa2_human(display_long)|uniprotkb:NCOA2(gene name)|psi-mi:NCOA2(display_short)|uniprotkb:TIF2(gene name synonym)|uniprotkb:Transcriptional intermediary factor 2(gene name synonym)|uniprotkb:BHLHE75(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 75(gene name synonym)|uniprotkb:SRC2(gene name synonym) psi-mi:rara_human(display_long)|uniprotkb:RARA(gene name)|psi-mi:RARA(display_short)|uniprotkb:NR1B1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group B member 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) le et al. (2010) pubmed:20543827|doi:10.1038/nsmb.1855|imex:IM-15985 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15860659|imex:IM-15985-8|dip:DIP-10883E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006531.1|rcsb pdb:1ZDU|rcsb pdb:1ZKY|rcsb pdb:2AO6|rcsb pdb:2B1V|rcsb pdb:2B1Z|rcsb pdb:2B23|rcsb pdb:2FAI|rcsb pdb:2G44|rcsb pdb:2G5O|rcsb pdb:2LDC|rcsb pdb:2P15|rcsb pdb:2P1T|rcsb pdb:2P1U|rcsb pdb:2P1V|rcsb pdb:2Q7J|rcsb pdb:2Q7L|rcsb pdb:2YJD|rcsb pdb:2ZXZ|rcsb pdb:2ZY0|rcsb pdb:3A9E|rcsb pdb:3CLD|rcsb pdb:3DZU|rcsb pdb:3DZY|rcsb pdb:3E00|rcsb pdb:3E7C|rcsb pdb:3E94|rcsb pdb:3ERD|rcsb pdb:3FUG|rcsb pdb:3GN8|rcsb pdb:3K22|rcsb pdb:3K23|rcsb pdb:3KWY|rcsb pdb:3KYT|rcsb pdb:3L0E|rcsb pdb:3L0J|rcsb pdb:3L0L|rcsb pdb:3O1D|rcsb pdb:3O1E|rcsb pdb:3OAP|rcsb pdb:3OZJ|rcsb pdb:3PCU|rcsb pdb:3PLZ|rcsb pdb:3Q95|rcsb pdb:3R5M|rcsb pdb:3UP0|rcsb pdb:3UP3|rcsb pdb:4CSJ|rcsb pdb:4DOS|rcsb pdb:4E2J|rcsb pdb:4FHH|rcsb pdb:4FHI|rcsb pdb:4IA1|rcsb pdb:4IA2|rcsb pdb:4IA3|rcsb pdb:4IA7|rcsb pdb:4IQR|interpro:IPR014920(Nuclear receptor coactivator, Ncoa-type, interlocking)|ensembl:ENSG00000140396(gene)|ensembl:ENST00000452400(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|interpro:IPR000014(PAS)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010011(Protein of unknown function DUF1518)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR014935(Steroid receptor coactivator)|interpro:IPR017426(Nuclear receptor coactivator)|interpro:IPR028822|interpro:IPR032565|interpro:IPR035965|interpro:IPR036638|interpro:IPR037077|mint:Q15596|rcsb pdb:1GWQ|rcsb pdb:1GWR|rcsb pdb:1M2Z|rcsb pdb:1MV9|rcsb pdb:1MVC|rcsb pdb:1MZN|rcsb pdb:1P93|rcsb pdb:1T63|rcsb pdb:1T65|rcsb pdb:1UHL|rcsb pdb:1YOK|rcsb pdb:1ZDT|rcsb pdb:4Q0A|rcsb pdb:4Q13|rcsb pdb:4QE6|rcsb pdb:4QE8|rcsb pdb:4RFW|rcsb pdb:4RMC|rcsb pdb:4RMD|rcsb pdb:4PXM|rcsb pdb:4RME|rcsb pdb:4RUO|rcsb pdb:4UDC|rcsb pdb:4UDD|rcsb pdb:4WG0|rcsb pdb:4ZN7|rcsb pdb:4ZN9|rcsb pdb:4ZNH|rcsb pdb:4ZNS|rcsb pdb:4ZNT|rcsb pdb:4ZNU|rcsb pdb:4ZNV|rcsb pdb:4ZNW|rcsb pdb:4ZO1|rcsb pdb:4ZSH|rcsb pdb:5APH|rcsb pdb:5APJ|rcsb pdb:5DI7|rcsb pdb:5DID|rcsb pdb:5DIE|rcsb pdb:5DIG|rcsb pdb:5DK9|rcsb pdb:5DKB|rcsb pdb:5DKE|rcsb pdb:4IUI|rcsb pdb:4IV2|rcsb pdb:4IV4|rcsb pdb:4IVW|rcsb pdb:4IVY|rcsb pdb:4IW6|rcsb pdb:4IW8|rcsb pdb:4IWC|rcsb pdb:4IWF|rcsb pdb:4K4J|rcsb pdb:4K6I|rcsb pdb:4M8E|rcsb pdb:4M8H|rcsb pdb:4NIE|rcsb pdb:4NQA|rcsb pdb:4OC7|rcsb pdb:4P6W|rcsb pdb:4P6X|rcsb pdb:4PLD|rcsb pdb:4PLE|rcsb pdb:4POH|rcsb pdb:4POJ|rcsb pdb:4PP3|rcsb pdb:4PP5|rcsb pdb:4IU7|rcsb pdb:4PP6|rcsb pdb:4PPP|rcsb pdb:4PPS|rcsb pdb:5DKG|rcsb pdb:5DKS|rcsb pdb:5DL4|rcsb pdb:5DLR|rcsb pdb:5DMC|rcsb pdb:5DMF|rcsb pdb:5DP0|rcsb pdb:5DRJ|rcsb pdb:5DRM|rcsb pdb:5DTV|rcsb pdb:5DU5|rcsb pdb:5DUE|rcsb pdb:5DUG|rcsb pdb:5DUH|rcsb pdb:5DVS|rcsb pdb:5DVV|rcsb pdb:5DWE|rcsb pdb:5DWG|rcsb pdb:5DWI|rcsb pdb:5DWJ|rcsb pdb:5DX3|rcsb pdb:5DXB|rcsb pdb:5DXE|rcsb pdb:5DXG|rcsb pdb:5DXK|rcsb pdb:5DXM|rcsb pdb:5DXP|rcsb pdb:5DXQ|rcsb pdb:5DXR|rcsb pdb:5DY8|rcsb pdb:5DYB|rcsb pdb:5DYD|rcsb pdb:5DZ0|rcsb pdb:5DZ1|rcsb pdb:5DZ3|rcsb pdb:5DZH|rcsb pdb:5DZI|rcsb pdb:5E0W|rcsb pdb:5E0X|rcsb pdb:5E14|rcsb pdb:5E15|rcsb pdb:5E19|rcsb pdb:5E1C|rcsb pdb:5EC9|rcsb pdb:5EGV|rcsb pdb:5EHJ|rcsb pdb:5EI1|rcsb pdb:5EIT|rcsb pdb:5G3J|rcsb pdb:5G42|rcsb pdb:5G43|rcsb pdb:5G44|rcsb pdb:5TMR|rcsb pdb:5TMS|rcsb pdb:5TMT|rcsb pdb:5TMU|rcsb pdb:5TMV|rcsb pdb:5TMW|rcsb pdb:5TMZ|rcsb pdb:5TN1|rcsb pdb:5TN3|rcsb pdb:5TN4|rcsb pdb:5TN5|rcsb pdb:5TN6|rcsb pdb:5TN7|rcsb pdb:5TN8|rcsb pdb:5U2D|rcsb pdb:5UAN|rcsb pdb:5VB3|rcsb pdb:5VB5|rcsb pdb:5VB6|rcsb pdb:5VB7|rcsb pdb:5G46|rcsb pdb:5G5W|rcsb pdb:5H1E|rcsb pdb:5HYR|rcsb pdb:5I4V|rcsb pdb:5IAW|rcsb pdb:5ICK|rcsb pdb:5KCC|rcsb pdb:5KCD|rcsb pdb:5KCE|rcsb pdb:5KCF|rcsb pdb:5KCT|rcsb pdb:5KCU|rcsb pdb:5KCW|rcsb pdb:5KD9|rcsb pdb:5KR9|rcsb pdb:5KRA|rcsb pdb:5KRC|rcsb pdb:5KRF|rcsb pdb:5KRH|rcsb pdb:5KRI|rcsb pdb:5KRJ|rcsb pdb:5KRK|rcsb pdb:5KRL|rcsb pdb:5KRM|rcsb pdb:5KRO|rcsb pdb:5L11|rcsb pdb:5LGA|rcsb pdb:5LYQ|rcsb pdb:5MK4|rcsb pdb:5G45|rcsb pdb:5NFP|rcsb pdb:5NFT|rcsb pdb:5NI5|rcsb pdb:5NI7|rcsb pdb:5NI8|rcsb pdb:5NIB|rcsb pdb:5Q17|rcsb pdb:5SYZ|rcsb pdb:5T1Z|rcsb pdb:5TLD|rcsb pdb:5TLF|rcsb pdb:5TLG|rcsb pdb:5TLL|rcsb pdb:5TLM|rcsb pdb:5TLO|rcsb pdb:5TLP|rcsb pdb:5TLT|rcsb pdb:5TLU|rcsb pdb:5TLV|rcsb pdb:5TLX|rcsb pdb:5TLY|rcsb pdb:5TM1|rcsb pdb:5TM2|rcsb pdb:5TM3|rcsb pdb:5TM4|rcsb pdb:5TM5|rcsb pdb:5TM6|rcsb pdb:5TM7|rcsb pdb:5TM8|rcsb pdb:5TM9|rcsb pdb:5TML|rcsb pdb:5TMM|rcsb pdb:5TMO|rcsb pdb:5TMQ|rcsb pdb:6KNU|rcsb pdb:6KNV|rcsb pdb:6KNW|rcsb pdb:6LB4|rcsb pdb:6LB5|rcsb pdb:6LB6|rcsb pdb:6LIT|rcsb pdb:6OQX|rcsb pdb:6OQY|rcsb pdb:6OR1|rcsb pdb:6R7A|rcsb pdb:6R7J|rcsb pdb:6R7K|rcsb pdb:6SJM|rcsb pdb:6STI|rcsb pdb:6VC2|rcsb pdb:6VIF|rcsb pdb:7A77|rcsb pdb:7A78|rcsb pdb:7A79|rcsb pdb:7B88|rcsb pdb:7B9O|rcsb pdb:7D42|rcsb pdb:6KKE|rcsb pdb:7JHD|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-159418|reactome:R-HSA-192105|reactome:R-HSA-193368|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-3214847|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5625886|reactome:R-HSA-9018519|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-193807|rcsb pdb:5VQL|rcsb pdb:5WGQ|rcsb pdb:5WZX|rcsb pdb:5XPL|rcsb pdb:5Y1J|rcsb pdb:5Y49|rcsb pdb:5YP5|rcsb pdb:5YXB|rcsb pdb:5YXD|rcsb pdb:5YXJ|rcsb pdb:5YXL|rcsb pdb:5Z12|rcsb pdb:6CZN|rcsb pdb:6D0F|rcsb pdb:5VQK|rcsb pdb:6EL6|rcsb pdb:6EL7|rcsb pdb:6EL9|rcsb pdb:6ESN|rcsb pdb:6KKB|refseq:NP_001308642.1|refseq:NP_001308632.1|refseq:NP_001308636.1|refseq:NP_001308640.1|refseq:NP_001308641.1|dip:DIP-5997N refseq:NP_000955.1|refseq:NP_001019980.1|refseq:NP_001138773.1|refseq:XP_011523397.1|refseq:NP_001138774.1|refseq:XP_005257610.1|refseq:XP_005257611.1|ensembl:ENSG00000131759(gene)|ensembl:ENST00000254066(transcript)|ensembl:ENST00000394089(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001889"(liver development)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0002068"(glandular epithelial cell development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030850"(prostate gland development)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0034097"(response to cytokine)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044323"(retinoic acid-responsive element binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060010"(Sertoli cell fate commitment)|go:"GO:0060173"(limb development)|go:"GO:0060324"(face development)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0061037"(negative regulation of cartilage development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10276|rcsb pdb:1DKF|rcsb pdb:1DSZ|rcsb pdb:3A9E|rcsb pdb:3KMR|rcsb pdb:3KMZ|rcsb pdb:4DQM|rcsb pdb:5K13|rcsb pdb:6XWG|reactome:R-HSA-4090294|reactome:R-HSA-5362517|reactome:R-HSA-5617472|reactome:R-HSA-9616222|reactome:R-HSA-383280|dip:DIP-34N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) - 2017/08/06 2017/08/10 rogid:dZP564B7sZPW/ro5h2CVE2XJJpk9606 rogid:hxW9W0aqa3qEJT5ZilJdJ4b+gEo9606 rigid:sOBK+DgNFe6UGKgekS1NPFG60Z4 false - sufficient binding region:176-403 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75376 uniprotkb:P10276 intact:EBI-347233|uniprotkb:E9PGV6|uniprotkb:Q86YY0|uniprotkb:Q9UPV5|uniprotkb:Q9UQ18|intact:EBI-28976482|ensembl:ENSP00000268712|uniprotkb:B3DLF8 intact:EBI-413374|uniprotkb:P78456|uniprotkb:Q13440|uniprotkb:Q13441|uniprotkb:Q96S41|uniprotkb:Q9NQS0|uniprotkb:B8Y636|ensembl:ENSP00000254066|ensembl:ENSP00000377649 psi-mi:ncor1_human(display_long)|uniprotkb:NCOR1(gene name)|psi-mi:NCOR1(display_short)|uniprotkb:KIAA1047(gene name synonym) psi-mi:rara_human(display_long)|uniprotkb:RARA(gene name)|psi-mi:RARA(display_short)|uniprotkb:NR1B1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group B member 1(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) le et al. (2010) pubmed:20543827|doi:10.1038/nsmb.1855|imex:IM-15985 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15860615|imex:IM-15985-6|dip:DIP-186532E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29402N|ensembl:ENSP00000268712|ensembl:ENST00000395848|ensembl:ENSP00000379189|ensembl:ENST00000395851|ensembl:ENSP00000379192|ensembl:ENSG00000141027(gene)|ensembl:ENST00000268712(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0016020"(membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:O75376|rcsb pdb:2EQR|rcsb pdb:3KMZ|rcsb pdb:3N00|rcsb pdb:4MDD|rcsb pdb:4WVD|rcsb pdb:6ONI|rcsb pdb:6WMQ|rcsb pdb:6XXS|rcsb pdb:6XYX|rcsb pdb:6XZZ|rcsb pdb:6Y17|rcsb pdb:6ZBU|reactome:R-HSA-1251985|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2173795|reactome:R-HSA-2644606|rcsb pdb:3H52|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|refseq:XP_011522388.1|refseq:NP_001177369.1|refseq:NP_006302.2|refseq:NP_001177367.1 refseq:NP_000955.1|refseq:NP_001019980.1|refseq:NP_001138773.1|refseq:XP_011523397.1|refseq:NP_001138774.1|refseq:XP_005257610.1|refseq:XP_005257611.1|ensembl:ENSG00000131759(gene)|ensembl:ENST00000254066(transcript)|ensembl:ENST00000394089(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001889"(liver development)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0002068"(glandular epithelial cell development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030850"(prostate gland development)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0034097"(response to cytokine)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044323"(retinoic acid-responsive element binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060010"(Sertoli cell fate commitment)|go:"GO:0060173"(limb development)|go:"GO:0060324"(face development)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0061037"(negative regulation of cartilage development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10276|rcsb pdb:1DKF|rcsb pdb:1DSZ|rcsb pdb:3A9E|rcsb pdb:3KMR|rcsb pdb:3KMZ|rcsb pdb:4DQM|rcsb pdb:5K13|rcsb pdb:6XWG|reactome:R-HSA-4090294|reactome:R-HSA-5362517|reactome:R-HSA-5617472|reactome:R-HSA-9616222|reactome:R-HSA-383280|dip:DIP-34N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:8W82xLRBbuJwVpXSvxoGQBu0v7Y9606 rogid:hxW9W0aqa3qEJT5ZilJdJ4b+gEo9606 rigid:yhJzD1t9YwaUpsJQgvCLeyofgF0 false binding-associated region:2047-2065 binding-associated region:176-421 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75376 uniprotkb:P10276 intact:EBI-347233|uniprotkb:E9PGV6|uniprotkb:Q86YY0|uniprotkb:Q9UPV5|uniprotkb:Q9UQ18|intact:EBI-28976482|ensembl:ENSP00000268712|uniprotkb:B3DLF8 intact:EBI-413374|uniprotkb:P78456|uniprotkb:Q13440|uniprotkb:Q13441|uniprotkb:Q96S41|uniprotkb:Q9NQS0|uniprotkb:B8Y636|ensembl:ENSP00000254066|ensembl:ENSP00000377649 psi-mi:ncor1_human(display_long)|uniprotkb:NCOR1(gene name)|psi-mi:NCOR1(display_short)|uniprotkb:KIAA1047(gene name synonym) psi-mi:rara_human(display_long)|uniprotkb:RARA(gene name)|psi-mi:RARA(display_short)|uniprotkb:NR1B1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group B member 1(gene name synonym) psi-mi:"MI:0017"(classical fluorescence spectroscopy) le et al. (2010) pubmed:20543827|doi:10.1038/nsmb.1855|imex:IM-15985 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15860678|imex:IM-15985-9|dip:DIP-186532E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29402N|ensembl:ENSP00000268712|ensembl:ENST00000395848|ensembl:ENSP00000379189|ensembl:ENST00000395851|ensembl:ENSP00000379192|ensembl:ENSG00000141027(gene)|ensembl:ENST00000268712(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0016020"(membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:O75376|rcsb pdb:2EQR|rcsb pdb:3KMZ|rcsb pdb:3N00|rcsb pdb:4MDD|rcsb pdb:4WVD|rcsb pdb:6ONI|rcsb pdb:6WMQ|rcsb pdb:6XXS|rcsb pdb:6XYX|rcsb pdb:6XZZ|rcsb pdb:6Y17|rcsb pdb:6ZBU|reactome:R-HSA-1251985|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2173795|reactome:R-HSA-2644606|rcsb pdb:3H52|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|refseq:XP_011522388.1|refseq:NP_001177369.1|refseq:NP_006302.2|refseq:NP_001177367.1 refseq:NP_000955.1|refseq:NP_001019980.1|refseq:NP_001138773.1|refseq:XP_011523397.1|refseq:NP_001138774.1|refseq:XP_005257610.1|refseq:XP_005257611.1|ensembl:ENSG00000131759(gene)|ensembl:ENST00000254066(transcript)|ensembl:ENST00000394089(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001889"(liver development)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0002068"(glandular epithelial cell development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030850"(prostate gland development)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0034097"(response to cytokine)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044323"(retinoic acid-responsive element binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060010"(Sertoli cell fate commitment)|go:"GO:0060173"(limb development)|go:"GO:0060324"(face development)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0061037"(negative regulation of cartilage development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10276|rcsb pdb:1DKF|rcsb pdb:1DSZ|rcsb pdb:3A9E|rcsb pdb:3KMR|rcsb pdb:3KMZ|rcsb pdb:4DQM|rcsb pdb:5K13|rcsb pdb:6XWG|reactome:R-HSA-4090294|reactome:R-HSA-5362517|reactome:R-HSA-5617472|reactome:R-HSA-9616222|reactome:R-HSA-383280|dip:DIP-34N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:8W82xLRBbuJwVpXSvxoGQBu0v7Y9606 rogid:hxW9W0aqa3qEJT5ZilJdJ4b+gEo9606 rigid:yhJzD1t9YwaUpsJQgvCLeyofgF0 false binding-associated region:2051-2065|fluorescein label:c-c binding-associated region:176-421 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y618 uniprotkb:P10276 intact:EBI-80830|uniprotkb:Q9Y5U0|uniprotkb:O00613|uniprotkb:O15416|uniprotkb:Q13354|uniprotkb:O15421|intact:EBI-28976851|uniprotkb:Q56D06|uniprotkb:Q59GM0|ensembl:ENSP00000384018 intact:EBI-413374|uniprotkb:P78456|uniprotkb:Q13440|uniprotkb:Q13441|uniprotkb:Q96S41|uniprotkb:Q9NQS0|uniprotkb:B8Y636|ensembl:ENSP00000254066|ensembl:ENSP00000377649 psi-mi:ncor2_human(display_long)|uniprotkb:NCOR2(gene name)|psi-mi:NCOR2(display_short)|uniprotkb:CTG26(gene name synonym)|uniprotkb:Silencing mediator of retinoic acid and thyroid hormone receptor(gene name synonym)|uniprotkb:Thyroid-, retinoic-acid-receptor-associated corepressor(gene name synonym)|uniprotkb:T3 receptor-associating factor(gene name synonym)|uniprotkb:CTG repeat protein 26(gene name synonym)|uniprotkb:SMAP270(gene name synonym) psi-mi:rara_human(display_long)|uniprotkb:RARA(gene name)|psi-mi:RARA(display_short)|uniprotkb:NR1B1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group B member 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) le et al. (2010) pubmed:20543827|doi:10.1038/nsmb.1855|imex:IM-15985 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15860547|imex:IM-15985-4|dip:DIP-75864E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000384018|refseq:NP_001070729.2|refseq:NP_001193583.1|refseq:NP_006303.4|dip:DIP-951N|ensembl:ENSG00000196498(gene)|ensembl:ENST00000405201(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007595"(lactation)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010565"(regulation of cellular ketone metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:Q9Y618|rcsb pdb:1KKQ|rcsb pdb:1R2B|rcsb pdb:1XC5|rcsb pdb:2GPV|rcsb pdb:2L5G|rcsb pdb:2LTP|rcsb pdb:2ODD|rcsb pdb:2RT5|rcsb pdb:3R29|rcsb pdb:3R2A|rcsb pdb:4A69|rcsb pdb:4OAR|rcsb pdb:5X8Q|rcsb pdb:5X8X|rcsb pdb:5ZOO|rcsb pdb:5ZOP|rcsb pdb:6A22|rcsb pdb:6IVX|rcsb pdb:6PDZ|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2173795|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564 refseq:NP_000955.1|refseq:NP_001019980.1|refseq:NP_001138773.1|refseq:XP_011523397.1|refseq:NP_001138774.1|refseq:XP_005257610.1|refseq:XP_005257611.1|ensembl:ENSG00000131759(gene)|ensembl:ENST00000254066(transcript)|ensembl:ENST00000394089(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001889"(liver development)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0002068"(glandular epithelial cell development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030850"(prostate gland development)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0034097"(response to cytokine)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044323"(retinoic acid-responsive element binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060010"(Sertoli cell fate commitment)|go:"GO:0060173"(limb development)|go:"GO:0060324"(face development)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0061037"(negative regulation of cartilage development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10276|rcsb pdb:1DKF|rcsb pdb:1DSZ|rcsb pdb:3A9E|rcsb pdb:3KMR|rcsb pdb:3KMZ|rcsb pdb:4DQM|rcsb pdb:5K13|rcsb pdb:6XWG|reactome:R-HSA-4090294|reactome:R-HSA-5362517|reactome:R-HSA-5617472|reactome:R-HSA-9616222|reactome:R-HSA-383280|dip:DIP-34N psi-mi:"MI:0465"(dip) - - figure legend:2b,c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2018/09/20 rogid:58SZfHIXN3dZN93fsiVHbbEwD0g9606 rogid:hxW9W0aqa3qEJT5ZilJdJ4b+gEo9606 rigid:r9y+KIjv+AAuThxPmHJlj/8+3qo false binding-associated region:982-c|mutation disrupting interaction:2140-2140,2139-2139|mutation decreasing interaction:2343-2343,2342-2342|mutation decreasing interaction:2128-2128|mutation disrupting interaction:2130-2130|mutation decreasing interaction:2131-2131 sufficient binding region:176-403|mutation disrupting interaction:396-396 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y618 uniprotkb:P10276 intact:EBI-80830|uniprotkb:Q9Y5U0|uniprotkb:O00613|uniprotkb:O15416|uniprotkb:Q13354|uniprotkb:O15421|intact:EBI-28976851|uniprotkb:Q56D06|uniprotkb:Q59GM0|ensembl:ENSP00000384018 intact:EBI-413374|uniprotkb:P78456|uniprotkb:Q13440|uniprotkb:Q13441|uniprotkb:Q96S41|uniprotkb:Q9NQS0|uniprotkb:B8Y636|ensembl:ENSP00000254066|ensembl:ENSP00000377649 psi-mi:ncor2_human(display_long)|uniprotkb:NCOR2(gene name)|psi-mi:NCOR2(display_short)|uniprotkb:CTG26(gene name synonym)|uniprotkb:Silencing mediator of retinoic acid and thyroid hormone receptor(gene name synonym)|uniprotkb:Thyroid-, retinoic-acid-receptor-associated corepressor(gene name synonym)|uniprotkb:T3 receptor-associating factor(gene name synonym)|uniprotkb:CTG repeat protein 26(gene name synonym)|uniprotkb:SMAP270(gene name synonym) psi-mi:rara_human(display_long)|uniprotkb:RARA(gene name)|psi-mi:RARA(display_short)|uniprotkb:NR1B1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group B member 1(gene name synonym) psi-mi:"MI:0017"(classical fluorescence spectroscopy) le et al. (2010) pubmed:20543827|doi:10.1038/nsmb.1855|imex:IM-15985 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15860588|imex:IM-15985-5|dip:DIP-75864E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000384018|refseq:NP_001070729.2|refseq:NP_001193583.1|refseq:NP_006303.4|dip:DIP-951N|ensembl:ENSG00000196498(gene)|ensembl:ENST00000405201(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007595"(lactation)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010565"(regulation of cellular ketone metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:Q9Y618|rcsb pdb:1KKQ|rcsb pdb:1R2B|rcsb pdb:1XC5|rcsb pdb:2GPV|rcsb pdb:2L5G|rcsb pdb:2LTP|rcsb pdb:2ODD|rcsb pdb:2RT5|rcsb pdb:3R29|rcsb pdb:3R2A|rcsb pdb:4A69|rcsb pdb:4OAR|rcsb pdb:5X8Q|rcsb pdb:5X8X|rcsb pdb:5ZOO|rcsb pdb:5ZOP|rcsb pdb:6A22|rcsb pdb:6IVX|rcsb pdb:6PDZ|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2173795|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564 refseq:NP_000955.1|refseq:NP_001019980.1|refseq:NP_001138773.1|refseq:XP_011523397.1|refseq:NP_001138774.1|refseq:XP_005257610.1|refseq:XP_005257611.1|ensembl:ENSG00000131759(gene)|ensembl:ENST00000254066(transcript)|ensembl:ENST00000394089(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001889"(liver development)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0002068"(glandular epithelial cell development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030850"(prostate gland development)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0034097"(response to cytokine)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044323"(retinoic acid-responsive element binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060010"(Sertoli cell fate commitment)|go:"GO:0060173"(limb development)|go:"GO:0060324"(face development)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0061037"(negative regulation of cartilage development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10276|rcsb pdb:1DKF|rcsb pdb:1DSZ|rcsb pdb:3A9E|rcsb pdb:3KMR|rcsb pdb:3KMZ|rcsb pdb:4DQM|rcsb pdb:5K13|rcsb pdb:6XWG|reactome:R-HSA-4090294|reactome:R-HSA-5362517|reactome:R-HSA-5617472|reactome:R-HSA-9616222|reactome:R-HSA-383280|dip:DIP-34N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2018/09/18 rogid:58SZfHIXN3dZN93fsiVHbbEwD0g9606 rogid:hxW9W0aqa3qEJT5ZilJdJ4b+gEo9606 rigid:r9y+KIjv+AAuThxPmHJlj/8+3qo false binding-associated region:2128-2146|fluorescent dye label:n-n binding-associated region:176-421|mutation decreasing interaction:396-396 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y618 uniprotkb:P10276 intact:EBI-80830|uniprotkb:Q9Y5U0|uniprotkb:O00613|uniprotkb:O15416|uniprotkb:Q13354|uniprotkb:O15421|intact:EBI-28976851|uniprotkb:Q56D06|uniprotkb:Q59GM0|ensembl:ENSP00000384018 intact:EBI-413374|uniprotkb:P78456|uniprotkb:Q13440|uniprotkb:Q13441|uniprotkb:Q96S41|uniprotkb:Q9NQS0|uniprotkb:B8Y636|ensembl:ENSP00000254066|ensembl:ENSP00000377649 psi-mi:ncor2_human(display_long)|uniprotkb:NCOR2(gene name)|psi-mi:NCOR2(display_short)|uniprotkb:CTG26(gene name synonym)|uniprotkb:Silencing mediator of retinoic acid and thyroid hormone receptor(gene name synonym)|uniprotkb:Thyroid-, retinoic-acid-receptor-associated corepressor(gene name synonym)|uniprotkb:T3 receptor-associating factor(gene name synonym)|uniprotkb:CTG repeat protein 26(gene name synonym)|uniprotkb:SMAP270(gene name synonym) psi-mi:rara_human(display_long)|uniprotkb:RARA(gene name)|psi-mi:RARA(display_short)|uniprotkb:NR1B1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group B member 1(gene name synonym) psi-mi:"MI:0017"(classical fluorescence spectroscopy) le et al. (2010) pubmed:20543827|doi:10.1038/nsmb.1855|imex:IM-15985 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15860701|imex:IM-15985-10|dip:DIP-75864E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000384018|refseq:NP_001070729.2|refseq:NP_001193583.1|refseq:NP_006303.4|dip:DIP-951N|ensembl:ENSG00000196498(gene)|ensembl:ENST00000405201(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007595"(lactation)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010565"(regulation of cellular ketone metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:Q9Y618|rcsb pdb:1KKQ|rcsb pdb:1R2B|rcsb pdb:1XC5|rcsb pdb:2GPV|rcsb pdb:2L5G|rcsb pdb:2LTP|rcsb pdb:2ODD|rcsb pdb:2RT5|rcsb pdb:3R29|rcsb pdb:3R2A|rcsb pdb:4A69|rcsb pdb:4OAR|rcsb pdb:5X8Q|rcsb pdb:5X8X|rcsb pdb:5ZOO|rcsb pdb:5ZOP|rcsb pdb:6A22|rcsb pdb:6IVX|rcsb pdb:6PDZ|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2173795|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564 refseq:NP_000955.1|refseq:NP_001019980.1|refseq:NP_001138773.1|refseq:XP_011523397.1|refseq:NP_001138774.1|refseq:XP_005257610.1|refseq:XP_005257611.1|ensembl:ENSG00000131759(gene)|ensembl:ENST00000254066(transcript)|ensembl:ENST00000394089(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001889"(liver development)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0002068"(glandular epithelial cell development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030850"(prostate gland development)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0034097"(response to cytokine)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044323"(retinoic acid-responsive element binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060010"(Sertoli cell fate commitment)|go:"GO:0060173"(limb development)|go:"GO:0060324"(face development)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0061037"(negative regulation of cartilage development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10276|rcsb pdb:1DKF|rcsb pdb:1DSZ|rcsb pdb:3A9E|rcsb pdb:3KMR|rcsb pdb:3KMZ|rcsb pdb:4DQM|rcsb pdb:5K13|rcsb pdb:6XWG|reactome:R-HSA-4090294|reactome:R-HSA-5362517|reactome:R-HSA-5617472|reactome:R-HSA-9616222|reactome:R-HSA-383280|dip:DIP-34N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2018/09/18 rogid:58SZfHIXN3dZN93fsiVHbbEwD0g9606 rogid:hxW9W0aqa3qEJT5ZilJdJ4b+gEo9606 rigid:r9y+KIjv+AAuThxPmHJlj/8+3qo false binding-associated region:2335-2356|fluorescein label:n-n binding-associated region:176-421|mutation decreasing interaction:396-396 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)