#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P04085-1	uniprotkb:P04085-1	intact:EBI-15499388|ensembl:ENSP00000346508	intact:EBI-15499388|ensembl:ENSP00000346508	psi-mi:p04085-1(display_long)|uniprotkb:PDGF-1(gene name synonym)|uniprotkb:Platelet-derived growth factor A chain(gene name synonym)|uniprotkb:Platelet-derived growth factor alpha polypeptide(gene name synonym)|uniprotkb:PDGFA(gene name)|psi-mi:PDGFA(display_short)|uniprotkb:PDGF1(gene name synonym)	psi-mi:p04085-1(display_long)|uniprotkb:PDGF-1(gene name synonym)|uniprotkb:Platelet-derived growth factor A chain(gene name synonym)|uniprotkb:Platelet-derived growth factor alpha polypeptide(gene name synonym)|uniprotkb:PDGFA(gene name)|psi-mi:PDGFA(display_short)|uniprotkb:PDGF1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Shim et al. (2010)	pubmed:20534510|doi:10.1073/pnas.1000806107|imex:IM-16431	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15858839|imex:IM-16431-1|dip:DIP-187643E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000197461(gene)|ensembl:ENST00000354513(transcript)|intact:EBI-2881386(isoform-parent)	ensembl:ENSG00000197461(gene)|ensembl:ENST00000354513(transcript)|intact:EBI-2881386(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini)|taxid:7111("Trichoplusia ni (Cabbage looper)")	-	2017/08/06	2017/08/10	rogid:tVWakd2xVLVMy4zTVWGKHkb399I9606	rogid:tVWakd2xVLVMy4zTVWGKHkb399I9606	rigid:qeBsHKouiav2RpUuvb8U/fzl7lo	false	binding-associated region:21-181	binding-associated region:21-181	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04085-1	uniprotkb:P04085-1	intact:EBI-15499388|ensembl:ENSP00000346508	intact:EBI-15499388|ensembl:ENSP00000346508	psi-mi:p04085-1(display_long)|uniprotkb:PDGF-1(gene name synonym)|uniprotkb:Platelet-derived growth factor A chain(gene name synonym)|uniprotkb:Platelet-derived growth factor alpha polypeptide(gene name synonym)|uniprotkb:PDGFA(gene name)|psi-mi:PDGFA(display_short)|uniprotkb:PDGF1(gene name synonym)	psi-mi:p04085-1(display_long)|uniprotkb:PDGF-1(gene name synonym)|uniprotkb:Platelet-derived growth factor A chain(gene name synonym)|uniprotkb:Platelet-derived growth factor alpha polypeptide(gene name synonym)|uniprotkb:PDGFA(gene name)|psi-mi:PDGFA(display_short)|uniprotkb:PDGF1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Shim et al. (2010)	pubmed:20534510|doi:10.1073/pnas.1000806107|imex:IM-16431	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15858879|imex:IM-16431-3|dip:DIP-187643E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000197461(gene)|ensembl:ENST00000354513(transcript)|intact:EBI-2881386(isoform-parent)	ensembl:ENSG00000197461(gene)|ensembl:ENST00000354513(transcript)|intact:EBI-2881386(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini)|taxid:7111("Trichoplusia ni (Cabbage looper)")	-	2017/08/06	2017/08/10	rogid:tVWakd2xVLVMy4zTVWGKHkb399I9606	rogid:tVWakd2xVLVMy4zTVWGKHkb399I9606	rigid:qeBsHKouiav2RpUuvb8U/fzl7lo	false	binding-associated region:21-181	binding-associated region:21-181	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09619	uniprotkb:P01127	intact:EBI-641237|uniprotkb:Q8N5L4|uniprotkb:B5A957|ensembl:ENSP00000261799	intact:EBI-1554925|uniprotkb:P78431|uniprotkb:Q9UF23|uniprotkb:G3XAG8|uniprotkb:Q15354|uniprotkb:Q6FHE7|ensembl:ENSP00000330382	psi-mi:pgfrb_human(display_long)|uniprotkb:CD140 antigen-like family member B(gene name synonym)|uniprotkb:PDGFRB(gene name)|psi-mi:PDGFRB(display_short)|uniprotkb:Beta-type platelet-derived growth factor receptor(gene name synonym)|uniprotkb:PDGFR(gene name synonym)|uniprotkb:Platelet-derived growth factor receptor 1(gene name synonym)|uniprotkb:Beta platelet-derived growth factor receptor(gene name synonym)|uniprotkb:PDGFR1(gene name synonym)	psi-mi:pdgfb_human(display_long)|uniprotkb:Platelet-derived growth factor B chain(gene name synonym)|uniprotkb:Platelet-derived growth factor beta polypeptide(gene name synonym)|uniprotkb:PDGF-2(gene name synonym)|uniprotkb:Proto-oncogene c-Sis(gene name synonym)|uniprotkb:PDGFB(gene name)|psi-mi:PDGFB(display_short)|uniprotkb:PDGF2(gene name synonym)|uniprotkb:SIS(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Shim et al. (2010)	pubmed:20534510|doi:10.1073/pnas.1000806107|imex:IM-16431	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15858898|imex:IM-16431-4|dip:DIP-9864E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002600.1|dip:DIP-558N|refseq:XP_011535960.1|refseq:XP_011535961.1|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0035789"(metanephric mesenchymal cell migration)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035793"(positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038091"(positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048839"(inner ear development)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060437"(lung growth)|go:"GO:0060981"(cell migration involved in coronary angiogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071670"(smooth muscle cell chemotaxis)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072262"(metanephric glomerular mesangial cell proliferation involved in metanephros development)|go:"GO:0072277"(metanephric glomerular capillary formation)|go:"GO:0072278"(metanephric comma-shaped body morphogenesis)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027288|interpro:IPR036179|mint:P09619|rcsb pdb:1GQ5|rcsb pdb:1H9O|rcsb pdb:1LWP|rcsb pdb:1SHA|rcsb pdb:2IUI|rcsb pdb:2L6W|rcsb pdb:2PLD|rcsb pdb:2PLE|rcsb pdb:3MJG|reactome:R-HSA-1257604|reactome:R-HSA-186763|reactome:R-HSA-186797|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|ensembl:ENSG00000113721(gene)|ensembl:ENST00000261799(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005017"(platelet-derived growth factor-activated receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008584"(male gonad development)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)	refseq:NP_002599.1|refseq:NP_148937.1|dip:DIP-5737N|ensembl:ENSG00000100311(gene)|ensembl:ENST00000331163(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0003104"(positive regulation of glomerular filtration)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010512"(negative regulation of phosphatidylinositol biosynthetic process)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035793"(positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0038001"(paracrine signaling)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071506"(cellular response to mycophenolic acid)|go:"GO:0072126"(positive regulation of glomerular mesangial cell proliferation)|go:"GO:0072255"(metanephric glomerular mesangial cell development)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1905176"(positive regulation of vascular associated smooth muscle cell dedifferentiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000591"(positive regulation of metanephric mesenchymal cell migration)|interpro:IPR000072("Platelet-derived growth factor (PDGF)")|interpro:IPR006782(Platelet-derived growth factor, N-terminal)|interpro:IPR015583(Platelet-Derived Growth Factor B Chain)|interpro:IPR023581|interpro:IPR029034|rcsb pdb:1PDG|rcsb pdb:3MJG|rcsb pdb:4HQU|rcsb pdb:4HQX|rcsb pdb:4QCI|rcsb pdb:6T9E|reactome:R-HSA-114608|reactome:R-HSA-1257604|reactome:R-HSA-186763|reactome:R-HSA-186797|reactome:R-HSA-2219530|reactome:R-HSA-3000171|reactome:R-HSA-5673001|reactome:R-HSA-6811558	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:J3OhdjjNQKvgErBLGYg4qBmoMBg9606	rogid:6zBbnXOTaM6thsuAbXfQoHHZ/EA9606	rigid:wzk8/ChEhgs7M5Bl2Ft580U4ScA	false	binding-associated region:33-314	binding-associated region:21-185	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09619	uniprotkb:P01127	intact:EBI-641237|uniprotkb:Q8N5L4|uniprotkb:B5A957|ensembl:ENSP00000261799	intact:EBI-1554925|uniprotkb:P78431|uniprotkb:Q9UF23|uniprotkb:G3XAG8|uniprotkb:Q15354|uniprotkb:Q6FHE7|ensembl:ENSP00000330382	psi-mi:pgfrb_human(display_long)|uniprotkb:CD140 antigen-like family member B(gene name synonym)|uniprotkb:PDGFRB(gene name)|psi-mi:PDGFRB(display_short)|uniprotkb:Beta-type platelet-derived growth factor receptor(gene name synonym)|uniprotkb:PDGFR(gene name synonym)|uniprotkb:Platelet-derived growth factor receptor 1(gene name synonym)|uniprotkb:Beta platelet-derived growth factor receptor(gene name synonym)|uniprotkb:PDGFR1(gene name synonym)	psi-mi:pdgfb_human(display_long)|uniprotkb:Platelet-derived growth factor B chain(gene name synonym)|uniprotkb:Platelet-derived growth factor beta polypeptide(gene name synonym)|uniprotkb:PDGF-2(gene name synonym)|uniprotkb:Proto-oncogene c-Sis(gene name synonym)|uniprotkb:PDGFB(gene name)|psi-mi:PDGFB(display_short)|uniprotkb:PDGF2(gene name synonym)|uniprotkb:SIS(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Shim et al. (2010)	pubmed:20534510|doi:10.1073/pnas.1000806107|imex:IM-16431	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15858857|imex:IM-16431-2|dip:DIP-9864E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002600.1|dip:DIP-558N|refseq:XP_011535960.1|refseq:XP_011535961.1|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0035789"(metanephric mesenchymal cell migration)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035793"(positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038091"(positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048839"(inner ear development)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060437"(lung growth)|go:"GO:0060981"(cell migration involved in coronary angiogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071670"(smooth muscle cell chemotaxis)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072262"(metanephric glomerular mesangial cell proliferation involved in metanephros development)|go:"GO:0072277"(metanephric glomerular capillary formation)|go:"GO:0072278"(metanephric comma-shaped body morphogenesis)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027288|interpro:IPR036179|mint:P09619|rcsb pdb:1GQ5|rcsb pdb:1H9O|rcsb pdb:1LWP|rcsb pdb:1SHA|rcsb pdb:2IUI|rcsb pdb:2L6W|rcsb pdb:2PLD|rcsb pdb:2PLE|rcsb pdb:3MJG|reactome:R-HSA-1257604|reactome:R-HSA-186763|reactome:R-HSA-186797|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|ensembl:ENSG00000113721(gene)|ensembl:ENST00000261799(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005017"(platelet-derived growth factor-activated receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008584"(male gonad development)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)	refseq:NP_002599.1|refseq:NP_148937.1|dip:DIP-5737N|ensembl:ENSG00000100311(gene)|ensembl:ENST00000331163(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0003104"(positive regulation of glomerular filtration)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010512"(negative regulation of phosphatidylinositol biosynthetic process)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035793"(positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0038001"(paracrine signaling)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071506"(cellular response to mycophenolic acid)|go:"GO:0072126"(positive regulation of glomerular mesangial cell proliferation)|go:"GO:0072255"(metanephric glomerular mesangial cell development)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1905176"(positive regulation of vascular associated smooth muscle cell dedifferentiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000591"(positive regulation of metanephric mesenchymal cell migration)|interpro:IPR000072("Platelet-derived growth factor (PDGF)")|interpro:IPR006782(Platelet-derived growth factor, N-terminal)|interpro:IPR015583(Platelet-Derived Growth Factor B Chain)|interpro:IPR023581|interpro:IPR029034|rcsb pdb:1PDG|rcsb pdb:3MJG|rcsb pdb:4HQU|rcsb pdb:4HQX|rcsb pdb:4QCI|rcsb pdb:6T9E|reactome:R-HSA-114608|reactome:R-HSA-1257604|reactome:R-HSA-186763|reactome:R-HSA-186797|reactome:R-HSA-2219530|reactome:R-HSA-3000171|reactome:R-HSA-5673001|reactome:R-HSA-6811558	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:J3OhdjjNQKvgErBLGYg4qBmoMBg9606	rogid:6zBbnXOTaM6thsuAbXfQoHHZ/EA9606	rigid:wzk8/ChEhgs7M5Bl2Ft580U4ScA	false	binding-associated region:33-314	binding-associated region:21-185	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16234-1	uniprotkb:Q9NRA1-1	intact:EBI-15499330|ensembl:ENSP00000257290	intact:EBI-15499301|ensembl:ENSP00000422464	psi-mi:p16234-1(display_long)|uniprotkb:Alpha platelet-derived growth factor receptor(gene name synonym)|uniprotkb:Alpha-type platelet-derived growth factor receptor(gene name synonym)|uniprotkb:CD140 antigen-like family member A(gene name synonym)|uniprotkb:CD140a antigen(gene name synonym)|uniprotkb:Platelet-derived growth factor alpha receptor(gene name synonym)|uniprotkb:Platelet-derived growth factor receptor 2(gene name synonym)|uniprotkb:PDGFRA(gene name)|psi-mi:PDGFRA(display_short)|uniprotkb:PDGFR2(gene name synonym)|uniprotkb:RHEPDGFRA(gene name synonym)	psi-mi:q9nra1-1(display_long)|uniprotkb:Fallotein(gene name synonym)|uniprotkb:Spinal cord-derived growth factor(gene name synonym)|uniprotkb:VEGF-E(gene name synonym)|uniprotkb:UNQ174/PRO200(orf name)|uniprotkb:PDGFC(gene name)|psi-mi:PDGFC(display_short)|uniprotkb:SCDGF(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Shim et al. (2010)	pubmed:20534510|doi:10.1073/pnas.1000806107|imex:IM-16431	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15858919|imex:IM-16431-5|dip:DIP-187644E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2861522(isoform-parent)|ensembl:ENSG00000134853(gene)|ensembl:ENST00000257290(transcript)	intact:EBI-8833587(isoform-parent)|ensembl:ENSG00000145431(gene)|ensembl:ENST00000502773(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:MkKEhNlBrHysJ4mct8Rvqjy2f7U9606	rogid:q61aPBV3efRYCOLKThu9ppVFNqY9606	rigid:/voxmdGdVKcdaJciBW4iLgARYWc	false	sufficient binding region:24-313	binding-associated region:235-345	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)