#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9H792 uniprotkb:P56945 intact:EBI-2609701|uniprotkb:Q6ZS78|uniprotkb:Q8TEG7|uniprotkb:Q8NCM3|uniprotkb:Q8NAZ4|ensembl:ENSP00000309230|ensembl:ENSP00000452796|ensembl:ENSP00000507603 intact:EBI-702093|uniprotkb:B4DIW5|uniprotkb:F8WA69|uniprotkb:Q6QEF7|uniprotkb:B7Z7X7|uniprotkb:F5GXV6|uniprotkb:B3KWD7|uniprotkb:B4DEV4|uniprotkb:B4DGB5|uniprotkb:E9PCL5|uniprotkb:E9PCV2|uniprotkb:F5GXA2|uniprotkb:F5H7Z0|intact:EBI-10963425|ensembl:ENSP00000162330 psi-mi:peak1_human(display_long)|uniprotkb:PEAK1(gene name)|psi-mi:PEAK1(display_short)|uniprotkb:KIAA2002(gene name synonym)|uniprotkb:Sugen kinase 269(gene name synonym)|uniprotkb:Tyrosine-protein kinase SgK269(gene name synonym)|uniprotkb:Pseudopodium-enriched atypical kinase 1(gene name synonym) psi-mi:bcar1_human(display_long)|uniprotkb:CRK-associated substrate(gene name synonym)|uniprotkb:p130cas(gene name synonym)|uniprotkb:BCAR1(gene name)|psi-mi:BCAR1(display_short)|uniprotkb:CAS(gene name synonym)|uniprotkb:CRKAS(gene name synonym)|uniprotkb:CASS1(gene name synonym)|uniprotkb:Cas scaffolding protein family member 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20534451|doi:10.1073/pnas.0914776107|imex:IM-17448 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15858035|imex:IM-17448-1|dip:DIP-188546E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011520335.1|refseq:XP_011520336.1|refseq:XP_011520337.1|refseq:XP_011520338.1|refseq:XP_011520339.1|refseq:XP_011520341.1|refseq:XP_011520340.1|refseq:NP_079052.2|refseq:XP_005254727.1|refseq:XP_005254728.1|refseq:XP_005254730.1|refseq:XP_005254731.1|refseq:XP_005254732.1|ensembl:ENSG00000173517(gene)|ensembl:ENST00000312493(transcript)|ensembl:ENST00000560626(transcript)|ensembl:ENST00000682557(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:6BHC|reactome:R-HSA-9013420|reactome:R-HSA-9013424|ensembl:ENSP00000309230|ensembl:ENSP00000452796|ensembl:ENSP00000507603|dip:DIP-56276N refseq:NP_001164185.1|refseq:NP_001164186.1|refseq:NP_001164187.1|refseq:NP_001164188.1|refseq:NP_001164189.1|refseq:NP_001164190.1|refseq:NP_001164191.1|refseq:NP_055382.2|refseq:XP_016879386.1|ensembl:ENSP00000162330|ensembl:ENST00000393420|ensembl:ENSP00000377072|ensembl:ENST00000393422|ensembl:ENSP00000377074|ensembl:ENST00000418647|ensembl:ENSP00000391669|ensembl:ENST00000420641|ensembl:ENSP00000392708|ensembl:ENST00000535626|ensembl:ENSP00000440370|ensembl:ENST00000538440|ensembl:ENSP00000443841|ensembl:ENST00000542031|ensembl:ENSP00000440415|dip:DIP-33855N|ensembl:ENSG00000050820(gene)|ensembl:ENST00000162330(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0050851"(antigen receptor-mediated signaling pathway)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051301"(cell division)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090527"(actin filament reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901|interpro:IPR028848|interpro:IPR035745|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|mint:P56945|rcsb pdb:1WYX|rcsb pdb:3T6G|rcsb pdb:5O2M|rcsb pdb:5O2P|rcsb pdb:5O2Q|reactome:R-HSA-186763|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:z2Q9mOQSYpc1fQJHovBCFsctX749606 rogid:ssRxMtaHJrQ1lMJ02FpOh3xIaWY9606 rigid:ys2sz1IQRn6ym0+uszLGXhgcelA false green fluorescent protein tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9H792 uniprotkb:P46108-1 intact:EBI-2609701|uniprotkb:Q6ZS78|uniprotkb:Q8TEG7|uniprotkb:Q8NCM3|uniprotkb:Q8NAZ4|ensembl:ENSP00000309230|ensembl:ENSP00000452796|ensembl:ENSP00000507603 intact:EBI-287556|ensembl:ENSP00000300574 psi-mi:peak1_human(display_long)|uniprotkb:PEAK1(gene name)|psi-mi:PEAK1(display_short)|uniprotkb:KIAA2002(gene name synonym)|uniprotkb:Sugen kinase 269(gene name synonym)|uniprotkb:Tyrosine-protein kinase SgK269(gene name synonym)|uniprotkb:Pseudopodium-enriched atypical kinase 1(gene name synonym) psi-mi:p46108-1(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20534451|doi:10.1073/pnas.0914776107|imex:IM-17448 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15858035|imex:IM-17448-1|dip:DIP-188546E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011520335.1|refseq:XP_011520336.1|refseq:XP_011520337.1|refseq:XP_011520338.1|refseq:XP_011520339.1|refseq:XP_011520341.1|refseq:XP_011520340.1|refseq:NP_079052.2|refseq:XP_005254727.1|refseq:XP_005254728.1|refseq:XP_005254730.1|refseq:XP_005254731.1|refseq:XP_005254732.1|ensembl:ENSG00000173517(gene)|ensembl:ENST00000312493(transcript)|ensembl:ENST00000560626(transcript)|ensembl:ENST00000682557(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:6BHC|reactome:R-HSA-9013420|reactome:R-HSA-9013424|ensembl:ENSP00000309230|ensembl:ENSP00000452796|ensembl:ENSP00000507603|dip:DIP-56276N intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:z2Q9mOQSYpc1fQJHovBCFsctX749606 rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606 rigid:ys2sz1IQRn6ym0+uszLGXhgcelA false green fluorescent protein tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9H792 uniprotkb:P56945 intact:EBI-2609701|uniprotkb:Q6ZS78|uniprotkb:Q8TEG7|uniprotkb:Q8NCM3|uniprotkb:Q8NAZ4|ensembl:ENSP00000309230|ensembl:ENSP00000452796|ensembl:ENSP00000507603 intact:EBI-702093|uniprotkb:B4DIW5|uniprotkb:F8WA69|uniprotkb:Q6QEF7|uniprotkb:B7Z7X7|uniprotkb:F5GXV6|uniprotkb:B3KWD7|uniprotkb:B4DEV4|uniprotkb:B4DGB5|uniprotkb:E9PCL5|uniprotkb:E9PCV2|uniprotkb:F5GXA2|uniprotkb:F5H7Z0|intact:EBI-10963425|ensembl:ENSP00000162330 psi-mi:peak1_human(display_long)|uniprotkb:PEAK1(gene name)|psi-mi:PEAK1(display_short)|uniprotkb:KIAA2002(gene name synonym)|uniprotkb:Sugen kinase 269(gene name synonym)|uniprotkb:Tyrosine-protein kinase SgK269(gene name synonym)|uniprotkb:Pseudopodium-enriched atypical kinase 1(gene name synonym) psi-mi:bcar1_human(display_long)|uniprotkb:CRK-associated substrate(gene name synonym)|uniprotkb:p130cas(gene name synonym)|uniprotkb:BCAR1(gene name)|psi-mi:BCAR1(display_short)|uniprotkb:CAS(gene name synonym)|uniprotkb:CRKAS(gene name synonym)|uniprotkb:CASS1(gene name synonym)|uniprotkb:Cas scaffolding protein family member 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20534451|doi:10.1073/pnas.0914776107|imex:IM-17448 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15858076|imex:IM-17448-3|dip:DIP-188546E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011520335.1|refseq:XP_011520336.1|refseq:XP_011520337.1|refseq:XP_011520338.1|refseq:XP_011520339.1|refseq:XP_011520341.1|refseq:XP_011520340.1|refseq:NP_079052.2|refseq:XP_005254727.1|refseq:XP_005254728.1|refseq:XP_005254730.1|refseq:XP_005254731.1|refseq:XP_005254732.1|ensembl:ENSG00000173517(gene)|ensembl:ENST00000312493(transcript)|ensembl:ENST00000560626(transcript)|ensembl:ENST00000682557(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:6BHC|reactome:R-HSA-9013420|reactome:R-HSA-9013424|ensembl:ENSP00000309230|ensembl:ENSP00000452796|ensembl:ENSP00000507603|dip:DIP-56276N refseq:NP_001164185.1|refseq:NP_001164186.1|refseq:NP_001164187.1|refseq:NP_001164188.1|refseq:NP_001164189.1|refseq:NP_001164190.1|refseq:NP_001164191.1|refseq:NP_055382.2|refseq:XP_016879386.1|ensembl:ENSP00000162330|ensembl:ENST00000393420|ensembl:ENSP00000377072|ensembl:ENST00000393422|ensembl:ENSP00000377074|ensembl:ENST00000418647|ensembl:ENSP00000391669|ensembl:ENST00000420641|ensembl:ENSP00000392708|ensembl:ENST00000535626|ensembl:ENSP00000440370|ensembl:ENST00000538440|ensembl:ENSP00000443841|ensembl:ENST00000542031|ensembl:ENSP00000440415|dip:DIP-33855N|ensembl:ENSG00000050820(gene)|ensembl:ENST00000162330(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0050851"(antigen receptor-mediated signaling pathway)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051301"(cell division)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090527"(actin filament reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901|interpro:IPR028848|interpro:IPR035745|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|mint:P56945|rcsb pdb:1WYX|rcsb pdb:3T6G|rcsb pdb:5O2M|rcsb pdb:5O2P|rcsb pdb:5O2Q|reactome:R-HSA-186763|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:z2Q9mOQSYpc1fQJHovBCFsctX749606 rogid:ssRxMtaHJrQ1lMJ02FpOh3xIaWY9606 rigid:ys2sz1IQRn6ym0+uszLGXhgcelA false green fluorescent protein tag:n-n|sufficient binding region:986-1746 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9H792 uniprotkb:P46108-1 intact:EBI-2609701|uniprotkb:Q6ZS78|uniprotkb:Q8TEG7|uniprotkb:Q8NCM3|uniprotkb:Q8NAZ4|ensembl:ENSP00000309230|ensembl:ENSP00000452796|ensembl:ENSP00000507603 intact:EBI-287556|ensembl:ENSP00000300574 psi-mi:peak1_human(display_long)|uniprotkb:PEAK1(gene name)|psi-mi:PEAK1(display_short)|uniprotkb:KIAA2002(gene name synonym)|uniprotkb:Sugen kinase 269(gene name synonym)|uniprotkb:Tyrosine-protein kinase SgK269(gene name synonym)|uniprotkb:Pseudopodium-enriched atypical kinase 1(gene name synonym) psi-mi:p46108-1(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20534451|doi:10.1073/pnas.0914776107|imex:IM-17448 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15858076|imex:IM-17448-3|dip:DIP-188546E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011520335.1|refseq:XP_011520336.1|refseq:XP_011520337.1|refseq:XP_011520338.1|refseq:XP_011520339.1|refseq:XP_011520341.1|refseq:XP_011520340.1|refseq:NP_079052.2|refseq:XP_005254727.1|refseq:XP_005254728.1|refseq:XP_005254730.1|refseq:XP_005254731.1|refseq:XP_005254732.1|ensembl:ENSG00000173517(gene)|ensembl:ENST00000312493(transcript)|ensembl:ENST00000560626(transcript)|ensembl:ENST00000682557(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:6BHC|reactome:R-HSA-9013420|reactome:R-HSA-9013424|ensembl:ENSP00000309230|ensembl:ENSP00000452796|ensembl:ENSP00000507603|dip:DIP-56276N intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:z2Q9mOQSYpc1fQJHovBCFsctX749606 rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606 rigid:ys2sz1IQRn6ym0+uszLGXhgcelA false green fluorescent protein tag:n-n|sufficient binding region:986-1746 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P56945 uniprotkb:Q9H792 intact:EBI-702093|uniprotkb:B4DIW5|uniprotkb:F8WA69|uniprotkb:Q6QEF7|uniprotkb:B7Z7X7|uniprotkb:F5GXV6|uniprotkb:B3KWD7|uniprotkb:B4DEV4|uniprotkb:B4DGB5|uniprotkb:E9PCL5|uniprotkb:E9PCV2|uniprotkb:F5GXA2|uniprotkb:F5H7Z0|intact:EBI-10963425|ensembl:ENSP00000162330 intact:EBI-2609701|uniprotkb:Q6ZS78|uniprotkb:Q8TEG7|uniprotkb:Q8NCM3|uniprotkb:Q8NAZ4|ensembl:ENSP00000309230|ensembl:ENSP00000452796|ensembl:ENSP00000507603 psi-mi:bcar1_human(display_long)|uniprotkb:CRK-associated substrate(gene name synonym)|uniprotkb:p130cas(gene name synonym)|uniprotkb:BCAR1(gene name)|psi-mi:BCAR1(display_short)|uniprotkb:CAS(gene name synonym)|uniprotkb:CRKAS(gene name synonym)|uniprotkb:CASS1(gene name synonym)|uniprotkb:Cas scaffolding protein family member 1(gene name synonym) psi-mi:peak1_human(display_long)|uniprotkb:PEAK1(gene name)|psi-mi:PEAK1(display_short)|uniprotkb:KIAA2002(gene name synonym)|uniprotkb:Sugen kinase 269(gene name synonym)|uniprotkb:Tyrosine-protein kinase SgK269(gene name synonym)|uniprotkb:Pseudopodium-enriched atypical kinase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2010) pubmed:20534451|doi:10.1073/pnas.0914776107|imex:IM-17448 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15858055|imex:IM-17448-2|dip:DIP-188547E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001164185.1|refseq:NP_001164186.1|refseq:NP_001164187.1|refseq:NP_001164188.1|refseq:NP_001164189.1|refseq:NP_001164190.1|refseq:NP_001164191.1|refseq:NP_055382.2|refseq:XP_016879386.1|ensembl:ENSP00000162330|ensembl:ENST00000393420|ensembl:ENSP00000377072|ensembl:ENST00000393422|ensembl:ENSP00000377074|ensembl:ENST00000418647|ensembl:ENSP00000391669|ensembl:ENST00000420641|ensembl:ENSP00000392708|ensembl:ENST00000535626|ensembl:ENSP00000440370|ensembl:ENST00000538440|ensembl:ENSP00000443841|ensembl:ENST00000542031|ensembl:ENSP00000440415|dip:DIP-33855N|ensembl:ENSG00000050820(gene)|ensembl:ENST00000162330(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0050851"(antigen receptor-mediated signaling pathway)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051301"(cell division)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090527"(actin filament reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901|interpro:IPR028848|interpro:IPR035745|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|mint:P56945|rcsb pdb:1WYX|rcsb pdb:3T6G|rcsb pdb:5O2M|rcsb pdb:5O2P|rcsb pdb:5O2Q|reactome:R-HSA-186763|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471 refseq:XP_011520335.1|refseq:XP_011520336.1|refseq:XP_011520337.1|refseq:XP_011520338.1|refseq:XP_011520339.1|refseq:XP_011520341.1|refseq:XP_011520340.1|refseq:NP_079052.2|refseq:XP_005254727.1|refseq:XP_005254728.1|refseq:XP_005254730.1|refseq:XP_005254731.1|refseq:XP_005254732.1|ensembl:ENSG00000173517(gene)|ensembl:ENST00000312493(transcript)|ensembl:ENST00000560626(transcript)|ensembl:ENST00000682557(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:6BHC|reactome:R-HSA-9013420|reactome:R-HSA-9013424|ensembl:ENSP00000309230|ensembl:ENSP00000452796|ensembl:ENSP00000507603|dip:DIP-56276N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:ssRxMtaHJrQ1lMJ02FpOh3xIaWY9606 rogid:z2Q9mOQSYpc1fQJHovBCFsctX749606 rigid:fO8XDbU+WdkbZ8BNs7pj4Dtu8OU false - green fluorescent protein tag:n-n|sufficient binding region:1-338 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9H792 uniprotkb:Q9H792 intact:EBI-2609701|uniprotkb:Q6ZS78|uniprotkb:Q8TEG7|uniprotkb:Q8NCM3|uniprotkb:Q8NAZ4|ensembl:ENSP00000309230|ensembl:ENSP00000452796|ensembl:ENSP00000507603 intact:EBI-2609701|uniprotkb:Q6ZS78|uniprotkb:Q8TEG7|uniprotkb:Q8NCM3|uniprotkb:Q8NAZ4|ensembl:ENSP00000309230|ensembl:ENSP00000452796|ensembl:ENSP00000507603 psi-mi:peak1_human(display_long)|uniprotkb:PEAK1(gene name)|psi-mi:PEAK1(display_short)|uniprotkb:KIAA2002(gene name synonym)|uniprotkb:Sugen kinase 269(gene name synonym)|uniprotkb:Tyrosine-protein kinase SgK269(gene name synonym)|uniprotkb:Pseudopodium-enriched atypical kinase 1(gene name synonym) psi-mi:peak1_human(display_long)|uniprotkb:PEAK1(gene name)|psi-mi:PEAK1(display_short)|uniprotkb:KIAA2002(gene name synonym)|uniprotkb:Sugen kinase 269(gene name synonym)|uniprotkb:Tyrosine-protein kinase SgK269(gene name synonym)|uniprotkb:Pseudopodium-enriched atypical kinase 1(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Wang et al. (2010) pubmed:20534451|doi:10.1073/pnas.0914776107|imex:IM-17448 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0465"(DIP) intact:EBI-15858098|imex:IM-17448-4|dip:DIP-188548E - - psi-mi:"MI:0898"(putative self) psi-mi:"MI:0898"(putative self) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011520335.1|refseq:XP_011520336.1|refseq:XP_011520337.1|refseq:XP_011520338.1|refseq:XP_011520339.1|refseq:XP_011520341.1|refseq:XP_011520340.1|refseq:NP_079052.2|refseq:XP_005254727.1|refseq:XP_005254728.1|refseq:XP_005254730.1|refseq:XP_005254731.1|refseq:XP_005254732.1|ensembl:ENSG00000173517(gene)|ensembl:ENST00000312493(transcript)|ensembl:ENST00000560626(transcript)|ensembl:ENST00000682557(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:6BHC|reactome:R-HSA-9013420|reactome:R-HSA-9013424|ensembl:ENSP00000309230|ensembl:ENSP00000452796|ensembl:ENSP00000507603|dip:DIP-56276N refseq:XP_011520335.1|refseq:XP_011520336.1|refseq:XP_011520337.1|refseq:XP_011520338.1|refseq:XP_011520339.1|refseq:XP_011520341.1|refseq:XP_011520340.1|refseq:NP_079052.2|refseq:XP_005254727.1|refseq:XP_005254728.1|refseq:XP_005254730.1|refseq:XP_005254731.1|refseq:XP_005254732.1|ensembl:ENSG00000173517(gene)|ensembl:ENST00000312493(transcript)|ensembl:ENST00000560626(transcript)|ensembl:ENST00000682557(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:6BHC|reactome:R-HSA-9013420|reactome:R-HSA-9013424|ensembl:ENSP00000309230|ensembl:ENSP00000452796|ensembl:ENSP00000507603|dip:DIP-56276N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:z2Q9mOQSYpc1fQJHovBCFsctX749606 rogid:z2Q9mOQSYpc1fQJHovBCFsctX749606 rigid:5XGV7h5rXhkoeh4EhebPWlZqU5o false glutathione s tranferase tag:n-n glutathione s tranferase tag:n-n - 0 psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)