#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P08200	uniprotkb:P11071	intact:EBI-369069|ensemblbacteria:AAC74220|ensemblbacteria:BAA35958	intact:EBI-1112800|uniprotkb:P11070|uniprotkb:Q2M6T8|ensemblbacteria:AAC76986|ensemblbacteria:BAE78018	psi-mi:idh_ecoli(display_long)|uniprotkb:icd(gene name)|psi-mi:icd(display_short)|uniprotkb:icdA(gene name synonym)|uniprotkb:icdE(gene name synonym)|uniprotkb:b1136(locus name)|uniprotkb:JW1122(locus name)|uniprotkb:Oxalosuccinate decarboxylase(gene name synonym)|uniprotkb:"NADP(+)-specific ICDH"(gene name synonym)|uniprotkb:IDP(gene name synonym)	psi-mi:acek_ecoli(display_long)|uniprotkb:aceK(gene name)|psi-mi:aceK(display_short)|uniprotkb:b4016(locus name)|uniprotkb:JW3976(locus name)	psi-mi:"MI:0071"(molecular sieving)	Zheng et al. (2010)	pubmed:20505668|doi:10.1038/nature09088|imex:IM-16306	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15856677|imex:IM-16306-1|dip:DIP-187470E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415654.1|refseq:WP_000444484.1|ensemblbacteria:AAC74220(transcript)|ensemblbacteria:b1136(gene)|ensemblbacteria:BAA35958(gene)|ensemblbacteria:BAA35958(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004450"("isocitrate dehydrogenase (NADP+) activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006097"(glyoxylate cycle)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0022900"(electron transport chain)|go:"GO:0051287"(NAD binding)|interpro:IPR004439(Isocitrate dehydrogenase NADP-dependent, prokaryotic)|interpro:IPR019818|interpro:IPR024084|rcsb pdb:1AI2|rcsb pdb:1AI3|rcsb pdb:1BL5|rcsb pdb:1CW1|rcsb pdb:1CW4|rcsb pdb:1CW7|rcsb pdb:1GRO|rcsb pdb:1GRP|rcsb pdb:1HJ6|rcsb pdb:1IDC|rcsb pdb:1IDD|rcsb pdb:1IDE|rcsb pdb:1IDF|rcsb pdb:1IKA|rcsb pdb:1ISO|rcsb pdb:1P8F|rcsb pdb:1PB1|rcsb pdb:1PB3|rcsb pdb:1SJS|rcsb pdb:3ICD|rcsb pdb:3LCB|rcsb pdb:4AJ3|rcsb pdb:4AJA|rcsb pdb:4AJB|rcsb pdb:4AJC|rcsb pdb:4AJR|rcsb pdb:4AJS|rcsb pdb:4BNP|rcsb pdb:4ICD|rcsb pdb:4P69|rcsb pdb:5ICD|rcsb pdb:6ICD|rcsb pdb:7ICD|rcsb pdb:8ICD|rcsb pdb:9ICD|dip:DIP-10006N	refseq:WP_001137220.1|refseq:NP_418440.1|ensemblbacteria:AAC76986(transcript)|ensemblbacteria:b4016(gene)|ensemblbacteria:BAE78018(gene)|ensemblbacteria:BAE78018(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006097"(glyoxylate cycle)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008772"("[isocitrate dehydrogenase (NADP+)] kinase activity")|go:"GO:0016208"(AMP binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|interpro:IPR010452(Isocitrate dehydrogenase kinasephosphatase)|rcsb pdb:6K5L|dip:DIP-9041N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:SNDyns4HsBiJFC6fsc7PtQ3DAN483333	rogid:+0d2bhEi9vHY0R8k8ogBcGbd4tQ83333	rigid:EiNnJZ5xcXEiRYTamcNjCvOitRA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08200	uniprotkb:P11071	intact:EBI-369069|ensemblbacteria:AAC74220|ensemblbacteria:BAA35958	intact:EBI-1112800|uniprotkb:P11070|uniprotkb:Q2M6T8|ensemblbacteria:AAC76986|ensemblbacteria:BAE78018	psi-mi:idh_ecoli(display_long)|uniprotkb:icd(gene name)|psi-mi:icd(display_short)|uniprotkb:icdA(gene name synonym)|uniprotkb:icdE(gene name synonym)|uniprotkb:b1136(locus name)|uniprotkb:JW1122(locus name)|uniprotkb:Oxalosuccinate decarboxylase(gene name synonym)|uniprotkb:"NADP(+)-specific ICDH"(gene name synonym)|uniprotkb:IDP(gene name synonym)	psi-mi:acek_ecoli(display_long)|uniprotkb:aceK(gene name)|psi-mi:aceK(display_short)|uniprotkb:b4016(locus name)|uniprotkb:JW3976(locus name)	psi-mi:"MI:0434"(phosphatase assay)	Zheng et al. (2010)	pubmed:20505668|doi:10.1038/nature09088|imex:IM-16306	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15856694|imex:IM-16306-2|dip:DIP-187470E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415654.1|refseq:WP_000444484.1|ensemblbacteria:AAC74220(transcript)|ensemblbacteria:b1136(gene)|ensemblbacteria:BAA35958(gene)|ensemblbacteria:BAA35958(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004450"("isocitrate dehydrogenase (NADP+) activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006097"(glyoxylate cycle)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0022900"(electron transport chain)|go:"GO:0051287"(NAD binding)|interpro:IPR004439(Isocitrate dehydrogenase NADP-dependent, prokaryotic)|interpro:IPR019818|interpro:IPR024084|rcsb pdb:1AI2|rcsb pdb:1AI3|rcsb pdb:1BL5|rcsb pdb:1CW1|rcsb pdb:1CW4|rcsb pdb:1CW7|rcsb pdb:1GRO|rcsb pdb:1GRP|rcsb pdb:1HJ6|rcsb pdb:1IDC|rcsb pdb:1IDD|rcsb pdb:1IDE|rcsb pdb:1IDF|rcsb pdb:1IKA|rcsb pdb:1ISO|rcsb pdb:1P8F|rcsb pdb:1PB1|rcsb pdb:1PB3|rcsb pdb:1SJS|rcsb pdb:3ICD|rcsb pdb:3LCB|rcsb pdb:4AJ3|rcsb pdb:4AJA|rcsb pdb:4AJB|rcsb pdb:4AJC|rcsb pdb:4AJR|rcsb pdb:4AJS|rcsb pdb:4BNP|rcsb pdb:4ICD|rcsb pdb:4P69|rcsb pdb:5ICD|rcsb pdb:6ICD|rcsb pdb:7ICD|rcsb pdb:8ICD|rcsb pdb:9ICD|dip:DIP-10006N	refseq:WP_001137220.1|refseq:NP_418440.1|ensemblbacteria:AAC76986(transcript)|ensemblbacteria:b4016(gene)|ensemblbacteria:BAE78018(gene)|ensemblbacteria:BAE78018(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006097"(glyoxylate cycle)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008772"("[isocitrate dehydrogenase (NADP+)] kinase activity")|go:"GO:0016208"(AMP binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|interpro:IPR010452(Isocitrate dehydrogenase kinasephosphatase)|rcsb pdb:6K5L|dip:DIP-9041N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:SNDyns4HsBiJFC6fsc7PtQ3DAN483333	rogid:+0d2bhEi9vHY0R8k8ogBcGbd4tQ83333	rigid:EiNnJZ5xcXEiRYTamcNjCvOitRA	false	-	mutation disrupting interaction:477-477|mutation disrupting interaction:346-346	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08200	uniprotkb:P11071	intact:EBI-369069|ensemblbacteria:AAC74220|ensemblbacteria:BAA35958	intact:EBI-1112800|uniprotkb:P11070|uniprotkb:Q2M6T8|ensemblbacteria:AAC76986|ensemblbacteria:BAE78018	psi-mi:idh_ecoli(display_long)|uniprotkb:icd(gene name)|psi-mi:icd(display_short)|uniprotkb:icdA(gene name synonym)|uniprotkb:icdE(gene name synonym)|uniprotkb:b1136(locus name)|uniprotkb:JW1122(locus name)|uniprotkb:Oxalosuccinate decarboxylase(gene name synonym)|uniprotkb:"NADP(+)-specific ICDH"(gene name synonym)|uniprotkb:IDP(gene name synonym)	psi-mi:acek_ecoli(display_long)|uniprotkb:aceK(gene name)|psi-mi:aceK(display_short)|uniprotkb:b4016(locus name)|uniprotkb:JW3976(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Zheng et al. (2010)	pubmed:20505668|doi:10.1038/nature09088|imex:IM-16306	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15856718|imex:IM-16306-3|dip:DIP-187470E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415654.1|refseq:WP_000444484.1|ensemblbacteria:AAC74220(transcript)|ensemblbacteria:b1136(gene)|ensemblbacteria:BAA35958(gene)|ensemblbacteria:BAA35958(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004450"("isocitrate dehydrogenase (NADP+) activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006097"(glyoxylate cycle)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0022900"(electron transport chain)|go:"GO:0051287"(NAD binding)|interpro:IPR004439(Isocitrate dehydrogenase NADP-dependent, prokaryotic)|interpro:IPR019818|interpro:IPR024084|rcsb pdb:1AI2|rcsb pdb:1AI3|rcsb pdb:1BL5|rcsb pdb:1CW1|rcsb pdb:1CW4|rcsb pdb:1CW7|rcsb pdb:1GRO|rcsb pdb:1GRP|rcsb pdb:1HJ6|rcsb pdb:1IDC|rcsb pdb:1IDD|rcsb pdb:1IDE|rcsb pdb:1IDF|rcsb pdb:1IKA|rcsb pdb:1ISO|rcsb pdb:1P8F|rcsb pdb:1PB1|rcsb pdb:1PB3|rcsb pdb:1SJS|rcsb pdb:3ICD|rcsb pdb:3LCB|rcsb pdb:4AJ3|rcsb pdb:4AJA|rcsb pdb:4AJB|rcsb pdb:4AJC|rcsb pdb:4AJR|rcsb pdb:4AJS|rcsb pdb:4BNP|rcsb pdb:4ICD|rcsb pdb:4P69|rcsb pdb:5ICD|rcsb pdb:6ICD|rcsb pdb:7ICD|rcsb pdb:8ICD|rcsb pdb:9ICD|dip:DIP-10006N	refseq:WP_001137220.1|refseq:NP_418440.1|ensemblbacteria:AAC76986(transcript)|ensemblbacteria:b4016(gene)|ensemblbacteria:BAE78018(gene)|ensemblbacteria:BAE78018(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006097"(glyoxylate cycle)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008772"("[isocitrate dehydrogenase (NADP+)] kinase activity")|go:"GO:0016208"(AMP binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|interpro:IPR010452(Isocitrate dehydrogenase kinasephosphatase)|rcsb pdb:6K5L|dip:DIP-9041N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:SNDyns4HsBiJFC6fsc7PtQ3DAN483333	rogid:+0d2bhEi9vHY0R8k8ogBcGbd4tQ83333	rigid:EiNnJZ5xcXEiRYTamcNjCvOitRA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08200	uniprotkb:P11071	intact:EBI-369069|ensemblbacteria:AAC74220|ensemblbacteria:BAA35958	intact:EBI-1112800|uniprotkb:P11070|uniprotkb:Q2M6T8|ensemblbacteria:AAC76986|ensemblbacteria:BAE78018	psi-mi:idh_ecoli(display_long)|uniprotkb:icd(gene name)|psi-mi:icd(display_short)|uniprotkb:icdA(gene name synonym)|uniprotkb:icdE(gene name synonym)|uniprotkb:b1136(locus name)|uniprotkb:JW1122(locus name)|uniprotkb:Oxalosuccinate decarboxylase(gene name synonym)|uniprotkb:"NADP(+)-specific ICDH"(gene name synonym)|uniprotkb:IDP(gene name synonym)	psi-mi:acek_ecoli(display_long)|uniprotkb:aceK(gene name)|psi-mi:aceK(display_short)|uniprotkb:b4016(locus name)|uniprotkb:JW3976(locus name)	psi-mi:"MI:0424"(protein kinase assay)	Zheng et al. (2010)	pubmed:20505668|doi:10.1038/nature09088|imex:IM-16306	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15856735|imex:IM-16306-4|dip:DIP-187470E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415654.1|refseq:WP_000444484.1|ensemblbacteria:AAC74220(transcript)|ensemblbacteria:b1136(gene)|ensemblbacteria:BAA35958(gene)|ensemblbacteria:BAA35958(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004450"("isocitrate dehydrogenase (NADP+) activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006097"(glyoxylate cycle)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0022900"(electron transport chain)|go:"GO:0051287"(NAD binding)|interpro:IPR004439(Isocitrate dehydrogenase NADP-dependent, prokaryotic)|interpro:IPR019818|interpro:IPR024084|rcsb pdb:1AI2|rcsb pdb:1AI3|rcsb pdb:1BL5|rcsb pdb:1CW1|rcsb pdb:1CW4|rcsb pdb:1CW7|rcsb pdb:1GRO|rcsb pdb:1GRP|rcsb pdb:1HJ6|rcsb pdb:1IDC|rcsb pdb:1IDD|rcsb pdb:1IDE|rcsb pdb:1IDF|rcsb pdb:1IKA|rcsb pdb:1ISO|rcsb pdb:1P8F|rcsb pdb:1PB1|rcsb pdb:1PB3|rcsb pdb:1SJS|rcsb pdb:3ICD|rcsb pdb:3LCB|rcsb pdb:4AJ3|rcsb pdb:4AJA|rcsb pdb:4AJB|rcsb pdb:4AJC|rcsb pdb:4AJR|rcsb pdb:4AJS|rcsb pdb:4BNP|rcsb pdb:4ICD|rcsb pdb:4P69|rcsb pdb:5ICD|rcsb pdb:6ICD|rcsb pdb:7ICD|rcsb pdb:8ICD|rcsb pdb:9ICD|dip:DIP-10006N	refseq:WP_001137220.1|refseq:NP_418440.1|ensemblbacteria:AAC76986(transcript)|ensemblbacteria:b4016(gene)|ensemblbacteria:BAE78018(gene)|ensemblbacteria:BAE78018(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006097"(glyoxylate cycle)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008772"("[isocitrate dehydrogenase (NADP+)] kinase activity")|go:"GO:0016208"(AMP binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|interpro:IPR010452(Isocitrate dehydrogenase kinasephosphatase)|rcsb pdb:6K5L|dip:DIP-9041N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:SNDyns4HsBiJFC6fsc7PtQ3DAN483333	rogid:+0d2bhEi9vHY0R8k8ogBcGbd4tQ83333	rigid:EiNnJZ5xcXEiRYTamcNjCvOitRA	false	-	mutation disrupting interaction:336-336|mutation disrupting interaction:475-475|mutation disrupting interaction:462-462|mutation disrupting interaction:499-499,497-497	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)