#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P38431 uniprotkb:P20459 intact:EBI-9038|ensemblfungi:YPR041W|uniprotkb:D6W450 intact:EBI-8915|uniprotkb:E9P8T6|ensemblfungi:YJR007W|uniprotkb:D6VWI2 psi-mi:if5_yeast(display_long)|uniprotkb:YP3085.05(orf name)|uniprotkb:YPR041W(locus name)|uniprotkb:TIF5(gene name)|psi-mi:TIF5(display_short) psi-mi:if2a_yeast(display_long)|uniprotkb:SUI2(gene name)|psi-mi:SUI2(display_short)|uniprotkb:TIF211(gene name synonym)|uniprotkb:YJR007W(locus name)|uniprotkb:J1429(orf name) psi-mi:"MI:0096"(pull down) Jennings et al. (2010) pubmed:20485439|doi:10.1038/nature09003|imex:IM-16312 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15855825|imex:IM-16312-1|dip:DIP-148589E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YPR041W(gene)|ensemblfungi:YPR041W_mRNA(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|rcsb pdb:2FUL|rcsb pdb:6FYX|rcsb pdb:6FYY|rcsb pdb:6ZU9|reactome:R-SCE-72702|go:"GO:0045947"(negative regulation of translational initiation)|refseq:NP_015366.1|sgd:S000006245|mint:P38431|dip:DIP-2303N interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|rcsb pdb:1Q46|rcsb pdb:2A19|rcsb pdb:2A1A|rcsb pdb:3J81|rcsb pdb:3JAP|rcsb pdb:3JAQ|rcsb pdb:6FYX|rcsb pdb:6FYY|rcsb pdb:6GSM|rcsb pdb:6GSN|rcsb pdb:6I3M|rcsb pdb:6I7T|rcsb pdb:6JLY|rcsb pdb:6JLZ|rcsb pdb:6QG0|rcsb pdb:6QG1|rcsb pdb:6QG2|rcsb pdb:6QG3|rcsb pdb:6QG5|rcsb pdb:6QG6|reactome:R-SCE-156827|reactome:R-SCE-381042|reactome:R-SCE-72649|reactome:R-SCE-72695|reactome:R-SCE-72702|reactome:R-SCE-72731|ensemblfungi:YJR007W(gene)|ensemblfungi:YJR007W_mRNA(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0043614"(multi-eIF complex)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|refseq:NP_012540.3|sgd:S000003767|mint:P20459|dip:DIP-2327N psi-mi:"MI:0465"(dip) crc64:1A1DA563B4ED1B1F crc64:AF4F1C80303A4E98 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:I7yqtuWuWgjiLFJcsU17mCtDs2Q559292 rogid:9/iGImP9/c8HSYwgmItME27z7lE559292 rigid:RV95znwf4O4nUhQY1Dpsfjy2pGw false sufficient binding region:241-405|glutathione s tranferase tag:n-n|mutation decreasing interaction:391-391 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P32481 uniprotkb:P09064 intact:EBI-8924|ensemblfungi:YER025W|uniprotkb:D3DLS4 intact:EBI-8920|ensemblfungi:YPL237W|uniprotkb:Q6B200|uniprotkb:D6W3D3 psi-mi:if2g_yeast(display_long)|uniprotkb:YER025W(locus name)|uniprotkb:GCD11(gene name)|psi-mi:GCD11(display_short)|uniprotkb:TIF213(gene name synonym)|uniprotkb:SUI4(gene name synonym) psi-mi:if2b_yeast(display_long)|uniprotkb:YPL237W(locus name)|uniprotkb:SUI3(gene name)|psi-mi:SUI3(display_short)|uniprotkb:TIF212(gene name synonym) psi-mi:"MI:0096"(pull down) Jennings et al. (2010) pubmed:20485439|doi:10.1038/nature09003|imex:IM-16312 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15855849|imex:IM-16312-2|dip:DIP-187476E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6I3M|rcsb pdb:6I7T|rcsb pdb:6QG0|rcsb pdb:6QG1|rcsb pdb:6QG2|rcsb pdb:6QG3|rcsb pdb:6QG5|rcsb pdb:6QG6|reactome:R-SCE-156827|reactome:R-SCE-381042|reactome:R-SCE-72649|reactome:R-SCE-72695|reactome:R-SCE-72702|reactome:R-SCE-72731|ensemblfungi:YER025W(gene)|ensemblfungi:YER025W_mRNA(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0045903"(positive regulation of translational fidelity)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR015256(Initiation factor eIF2 gamma, C terminal)|interpro:IPR027417|interpro:IPR044127|interpro:IPR044128|rcsb pdb:3J81|rcsb pdb:3JAP|rcsb pdb:3JAQ|rcsb pdb:4ZGN|rcsb pdb:4ZGQ|rcsb pdb:6FYX|rcsb pdb:6FYY|rcsb pdb:6GSM|rcsb pdb:6GSN|refseq:NP_010942.1|sgd:S000000827|mint:P32481|dip:DIP-2561N ensemblfungi:YPL237W(gene)|ensemblfungi:YPL237W_mRNA(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|rcsb pdb:3J81|rcsb pdb:3JAP|rcsb pdb:3JAQ|rcsb pdb:6FYX|rcsb pdb:6FYY|rcsb pdb:6GSM|rcsb pdb:6GSN|rcsb pdb:6I3M|rcsb pdb:6I7T|rcsb pdb:6QG0|rcsb pdb:6QG1|rcsb pdb:6QG2|rcsb pdb:6QG3|rcsb pdb:6QG5|rcsb pdb:6QG6|reactome:R-SCE-72649|refseq:NP_015087.1|sgd:S000006158|reactome:R-SCE-156827|reactome:R-SCE-72695|reactome:R-SCE-72702|reactome:R-SCE-72731|dip:DIP-2310N|reactome:R-SCE-381042 psi-mi:"MI:0465"(dip) crc64:D498AE62BC3E81CD crc64:34DE9323876CEE95 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:KLaBewFsp1tygK0+hirsBIaMPEI559292 rogid:64fjjpMNrNM6gZW2BzacUQWRC1I559292 rigid:qTPyHktlj1ToFFmcNf8R0+DycuI false his tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P32481 uniprotkb:P20459 intact:EBI-8924|ensemblfungi:YER025W|uniprotkb:D3DLS4 intact:EBI-8915|uniprotkb:E9P8T6|ensemblfungi:YJR007W|uniprotkb:D6VWI2 psi-mi:if2g_yeast(display_long)|uniprotkb:YER025W(locus name)|uniprotkb:GCD11(gene name)|psi-mi:GCD11(display_short)|uniprotkb:TIF213(gene name synonym)|uniprotkb:SUI4(gene name synonym) psi-mi:if2a_yeast(display_long)|uniprotkb:SUI2(gene name)|psi-mi:SUI2(display_short)|uniprotkb:TIF211(gene name synonym)|uniprotkb:YJR007W(locus name)|uniprotkb:J1429(orf name) psi-mi:"MI:0096"(pull down) Jennings et al. (2010) pubmed:20485439|doi:10.1038/nature09003|imex:IM-16312 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15855849|imex:IM-16312-2|dip:DIP-187476E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6I3M|rcsb pdb:6I7T|rcsb pdb:6QG0|rcsb pdb:6QG1|rcsb pdb:6QG2|rcsb pdb:6QG3|rcsb pdb:6QG5|rcsb pdb:6QG6|reactome:R-SCE-156827|reactome:R-SCE-381042|reactome:R-SCE-72649|reactome:R-SCE-72695|reactome:R-SCE-72702|reactome:R-SCE-72731|ensemblfungi:YER025W(gene)|ensemblfungi:YER025W_mRNA(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0045903"(positive regulation of translational fidelity)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR015256(Initiation factor eIF2 gamma, C terminal)|interpro:IPR027417|interpro:IPR044127|interpro:IPR044128|rcsb pdb:3J81|rcsb pdb:3JAP|rcsb pdb:3JAQ|rcsb pdb:4ZGN|rcsb pdb:4ZGQ|rcsb pdb:6FYX|rcsb pdb:6FYY|rcsb pdb:6GSM|rcsb pdb:6GSN|refseq:NP_010942.1|sgd:S000000827|mint:P32481|dip:DIP-2561N interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|rcsb pdb:1Q46|rcsb pdb:2A19|rcsb pdb:2A1A|rcsb pdb:3J81|rcsb pdb:3JAP|rcsb pdb:3JAQ|rcsb pdb:6FYX|rcsb pdb:6FYY|rcsb pdb:6GSM|rcsb pdb:6GSN|rcsb pdb:6I3M|rcsb pdb:6I7T|rcsb pdb:6JLY|rcsb pdb:6JLZ|rcsb pdb:6QG0|rcsb pdb:6QG1|rcsb pdb:6QG2|rcsb pdb:6QG3|rcsb pdb:6QG5|rcsb pdb:6QG6|reactome:R-SCE-156827|reactome:R-SCE-381042|reactome:R-SCE-72649|reactome:R-SCE-72695|reactome:R-SCE-72702|reactome:R-SCE-72731|ensemblfungi:YJR007W(gene)|ensemblfungi:YJR007W_mRNA(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0043614"(multi-eIF complex)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|refseq:NP_012540.3|sgd:S000003767|mint:P20459|dip:DIP-2327N psi-mi:"MI:0465"(dip) crc64:D498AE62BC3E81CD crc64:AF4F1C80303A4E98 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:KLaBewFsp1tygK0+hirsBIaMPEI559292 rogid:9/iGImP9/c8HSYwgmItME27z7lE559292 rigid:qTPyHktlj1ToFFmcNf8R0+DycuI false his tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P38431 uniprotkb:P20459 intact:EBI-9038|ensemblfungi:YPR041W|uniprotkb:D6W450 intact:EBI-8915|uniprotkb:E9P8T6|ensemblfungi:YJR007W|uniprotkb:D6VWI2 psi-mi:if5_yeast(display_long)|uniprotkb:YP3085.05(orf name)|uniprotkb:YPR041W(locus name)|uniprotkb:TIF5(gene name)|psi-mi:TIF5(display_short) psi-mi:if2a_yeast(display_long)|uniprotkb:SUI2(gene name)|psi-mi:SUI2(display_short)|uniprotkb:TIF211(gene name synonym)|uniprotkb:YJR007W(locus name)|uniprotkb:J1429(orf name) psi-mi:"MI:0096"(pull down) Jennings et al. (2010) pubmed:20485439|doi:10.1038/nature09003|imex:IM-16312 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15855869|imex:IM-16312-3|dip:DIP-187477E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YPR041W(gene)|ensemblfungi:YPR041W_mRNA(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|rcsb pdb:2FUL|rcsb pdb:6FYX|rcsb pdb:6FYY|rcsb pdb:6ZU9|reactome:R-SCE-72702|go:"GO:0045947"(negative regulation of translational initiation)|refseq:NP_015366.1|sgd:S000006245|mint:P38431|dip:DIP-2303N interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|rcsb pdb:1Q46|rcsb pdb:2A19|rcsb pdb:2A1A|rcsb pdb:3J81|rcsb pdb:3JAP|rcsb pdb:3JAQ|rcsb pdb:6FYX|rcsb pdb:6FYY|rcsb pdb:6GSM|rcsb pdb:6GSN|rcsb pdb:6I3M|rcsb pdb:6I7T|rcsb pdb:6JLY|rcsb pdb:6JLZ|rcsb pdb:6QG0|rcsb pdb:6QG1|rcsb pdb:6QG2|rcsb pdb:6QG3|rcsb pdb:6QG5|rcsb pdb:6QG6|reactome:R-SCE-156827|reactome:R-SCE-381042|reactome:R-SCE-72649|reactome:R-SCE-72695|reactome:R-SCE-72702|reactome:R-SCE-72731|ensemblfungi:YJR007W(gene)|ensemblfungi:YJR007W_mRNA(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0043614"(multi-eIF complex)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|refseq:NP_012540.3|sgd:S000003767|mint:P20459|dip:DIP-2327N psi-mi:"MI:0465"(dip) crc64:1A1DA563B4ED1B1F crc64:AF4F1C80303A4E98 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:I7yqtuWuWgjiLFJcsU17mCtDs2Q559292 rogid:9/iGImP9/c8HSYwgmItME27z7lE559292 rigid:1i7qOcpmuYMdWNcKAyUiQraq4Kk false glutathione s tranferase tag:n-n|sufficient binding region:241-405 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P38431 uniprotkb:P32481 intact:EBI-9038|ensemblfungi:YPR041W|uniprotkb:D6W450 intact:EBI-8924|ensemblfungi:YER025W|uniprotkb:D3DLS4 psi-mi:if5_yeast(display_long)|uniprotkb:YP3085.05(orf name)|uniprotkb:YPR041W(locus name)|uniprotkb:TIF5(gene name)|psi-mi:TIF5(display_short) psi-mi:if2g_yeast(display_long)|uniprotkb:YER025W(locus name)|uniprotkb:GCD11(gene name)|psi-mi:GCD11(display_short)|uniprotkb:TIF213(gene name synonym)|uniprotkb:SUI4(gene name synonym) psi-mi:"MI:0096"(pull down) Jennings et al. (2010) pubmed:20485439|doi:10.1038/nature09003|imex:IM-16312 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15855869|imex:IM-16312-3|dip:DIP-187477E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YPR041W(gene)|ensemblfungi:YPR041W_mRNA(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|rcsb pdb:2FUL|rcsb pdb:6FYX|rcsb pdb:6FYY|rcsb pdb:6ZU9|reactome:R-SCE-72702|go:"GO:0045947"(negative regulation of translational initiation)|refseq:NP_015366.1|sgd:S000006245|mint:P38431|dip:DIP-2303N rcsb pdb:6I3M|rcsb pdb:6I7T|rcsb pdb:6QG0|rcsb pdb:6QG1|rcsb pdb:6QG2|rcsb pdb:6QG3|rcsb pdb:6QG5|rcsb pdb:6QG6|reactome:R-SCE-156827|reactome:R-SCE-381042|reactome:R-SCE-72649|reactome:R-SCE-72695|reactome:R-SCE-72702|reactome:R-SCE-72731|ensemblfungi:YER025W(gene)|ensemblfungi:YER025W_mRNA(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0045903"(positive regulation of translational fidelity)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR015256(Initiation factor eIF2 gamma, C terminal)|interpro:IPR027417|interpro:IPR044127|interpro:IPR044128|rcsb pdb:3J81|rcsb pdb:3JAP|rcsb pdb:3JAQ|rcsb pdb:4ZGN|rcsb pdb:4ZGQ|rcsb pdb:6FYX|rcsb pdb:6FYY|rcsb pdb:6GSM|rcsb pdb:6GSN|refseq:NP_010942.1|sgd:S000000827|mint:P32481|dip:DIP-2561N psi-mi:"MI:0465"(dip) crc64:1A1DA563B4ED1B1F crc64:D498AE62BC3E81CD full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:I7yqtuWuWgjiLFJcsU17mCtDs2Q559292 rogid:KLaBewFsp1tygK0+hirsBIaMPEI559292 rigid:1i7qOcpmuYMdWNcKAyUiQraq4Kk false glutathione s tranferase tag:n-n|sufficient binding region:241-405 myc tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P38431 uniprotkb:P20459 intact:EBI-9038|ensemblfungi:YPR041W|uniprotkb:D6W450 intact:EBI-8915|uniprotkb:E9P8T6|ensemblfungi:YJR007W|uniprotkb:D6VWI2 psi-mi:if5_yeast(display_long)|uniprotkb:YP3085.05(orf name)|uniprotkb:YPR041W(locus name)|uniprotkb:TIF5(gene name)|psi-mi:TIF5(display_short) psi-mi:if2a_yeast(display_long)|uniprotkb:SUI2(gene name)|psi-mi:SUI2(display_short)|uniprotkb:TIF211(gene name synonym)|uniprotkb:YJR007W(locus name)|uniprotkb:J1429(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jennings et al. (2010) pubmed:20485439|doi:10.1038/nature09003|imex:IM-16312 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15855893|imex:IM-16312-4|dip:DIP-148589E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YPR041W(gene)|ensemblfungi:YPR041W_mRNA(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|rcsb pdb:2FUL|rcsb pdb:6FYX|rcsb pdb:6FYY|rcsb pdb:6ZU9|reactome:R-SCE-72702|go:"GO:0045947"(negative regulation of translational initiation)|refseq:NP_015366.1|sgd:S000006245|mint:P38431|dip:DIP-2303N interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|rcsb pdb:1Q46|rcsb pdb:2A19|rcsb pdb:2A1A|rcsb pdb:3J81|rcsb pdb:3JAP|rcsb pdb:3JAQ|rcsb pdb:6FYX|rcsb pdb:6FYY|rcsb pdb:6GSM|rcsb pdb:6GSN|rcsb pdb:6I3M|rcsb pdb:6I7T|rcsb pdb:6JLY|rcsb pdb:6JLZ|rcsb pdb:6QG0|rcsb pdb:6QG1|rcsb pdb:6QG2|rcsb pdb:6QG3|rcsb pdb:6QG5|rcsb pdb:6QG6|reactome:R-SCE-156827|reactome:R-SCE-381042|reactome:R-SCE-72649|reactome:R-SCE-72695|reactome:R-SCE-72702|reactome:R-SCE-72731|ensemblfungi:YJR007W(gene)|ensemblfungi:YJR007W_mRNA(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0043614"(multi-eIF complex)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|refseq:NP_012540.3|sgd:S000003767|mint:P20459|dip:DIP-2327N psi-mi:"MI:0465"(dip) crc64:1A1DA563B4ED1B1F crc64:AF4F1C80303A4E98 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:I7yqtuWuWgjiLFJcsU17mCtDs2Q559292 rogid:9/iGImP9/c8HSYwgmItME27z7lE559292 rigid:RV95znwf4O4nUhQY1Dpsfjy2pGw false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P32481 uniprotkb:P38431 intact:EBI-8924|ensemblfungi:YER025W|uniprotkb:D3DLS4 intact:EBI-9038|ensemblfungi:YPR041W|uniprotkb:D6W450 psi-mi:if2g_yeast(display_long)|uniprotkb:YER025W(locus name)|uniprotkb:GCD11(gene name)|psi-mi:GCD11(display_short)|uniprotkb:TIF213(gene name synonym)|uniprotkb:SUI4(gene name synonym) psi-mi:if5_yeast(display_long)|uniprotkb:YP3085.05(orf name)|uniprotkb:YPR041W(locus name)|uniprotkb:TIF5(gene name)|psi-mi:TIF5(display_short) psi-mi:"MI:0096"(pull down) Jennings et al. (2010) pubmed:20485439|doi:10.1038/nature09003|imex:IM-16312 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15855912|imex:IM-16312-5|dip:DIP-82259E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6I3M|rcsb pdb:6I7T|rcsb pdb:6QG0|rcsb pdb:6QG1|rcsb pdb:6QG2|rcsb pdb:6QG3|rcsb pdb:6QG5|rcsb pdb:6QG6|reactome:R-SCE-156827|reactome:R-SCE-381042|reactome:R-SCE-72649|reactome:R-SCE-72695|reactome:R-SCE-72702|reactome:R-SCE-72731|ensemblfungi:YER025W(gene)|ensemblfungi:YER025W_mRNA(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0045903"(positive regulation of translational fidelity)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR015256(Initiation factor eIF2 gamma, C terminal)|interpro:IPR027417|interpro:IPR044127|interpro:IPR044128|rcsb pdb:3J81|rcsb pdb:3JAP|rcsb pdb:3JAQ|rcsb pdb:4ZGN|rcsb pdb:4ZGQ|rcsb pdb:6FYX|rcsb pdb:6FYY|rcsb pdb:6GSM|rcsb pdb:6GSN|refseq:NP_010942.1|sgd:S000000827|mint:P32481|dip:DIP-2561N ensemblfungi:YPR041W(gene)|ensemblfungi:YPR041W_mRNA(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|rcsb pdb:2FUL|rcsb pdb:6FYX|rcsb pdb:6FYY|rcsb pdb:6ZU9|reactome:R-SCE-72702|go:"GO:0045947"(negative regulation of translational initiation)|refseq:NP_015366.1|sgd:S000006245|mint:P38431|dip:DIP-2303N psi-mi:"MI:0465"(dip) crc64:D498AE62BC3E81CD crc64:1A1DA563B4ED1B1F full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:KLaBewFsp1tygK0+hirsBIaMPEI559292 rogid:I7yqtuWuWgjiLFJcsU17mCtDs2Q559292 rigid:17Fj2RK4NctEW8qslWNDj5PA0Ts false - sufficient binding region:241-405|glutathione s tranferase tag:n-n|mutation decreasing interaction:391-391 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P38431 uniprotkb:P20459 intact:EBI-9038|ensemblfungi:YPR041W|uniprotkb:D6W450 intact:EBI-8915|uniprotkb:E9P8T6|ensemblfungi:YJR007W|uniprotkb:D6VWI2 psi-mi:if5_yeast(display_long)|uniprotkb:YP3085.05(orf name)|uniprotkb:YPR041W(locus name)|uniprotkb:TIF5(gene name)|psi-mi:TIF5(display_short) psi-mi:if2a_yeast(display_long)|uniprotkb:SUI2(gene name)|psi-mi:SUI2(display_short)|uniprotkb:TIF211(gene name synonym)|uniprotkb:YJR007W(locus name)|uniprotkb:J1429(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jennings et al. (2010) pubmed:20485439|doi:10.1038/nature09003|imex:IM-16312 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15855936|imex:IM-16312-6|dip:DIP-187477E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YPR041W(gene)|ensemblfungi:YPR041W_mRNA(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|rcsb pdb:2FUL|rcsb pdb:6FYX|rcsb pdb:6FYY|rcsb pdb:6ZU9|reactome:R-SCE-72702|go:"GO:0045947"(negative regulation of translational initiation)|refseq:NP_015366.1|sgd:S000006245|mint:P38431|dip:DIP-2303N interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|rcsb pdb:1Q46|rcsb pdb:2A19|rcsb pdb:2A1A|rcsb pdb:3J81|rcsb pdb:3JAP|rcsb pdb:3JAQ|rcsb pdb:6FYX|rcsb pdb:6FYY|rcsb pdb:6GSM|rcsb pdb:6GSN|rcsb pdb:6I3M|rcsb pdb:6I7T|rcsb pdb:6JLY|rcsb pdb:6JLZ|rcsb pdb:6QG0|rcsb pdb:6QG1|rcsb pdb:6QG2|rcsb pdb:6QG3|rcsb pdb:6QG5|rcsb pdb:6QG6|reactome:R-SCE-156827|reactome:R-SCE-381042|reactome:R-SCE-72649|reactome:R-SCE-72695|reactome:R-SCE-72702|reactome:R-SCE-72731|ensemblfungi:YJR007W(gene)|ensemblfungi:YJR007W_mRNA(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0043614"(multi-eIF complex)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|refseq:NP_012540.3|sgd:S000003767|mint:P20459|dip:DIP-2327N psi-mi:"MI:0465"(dip) crc64:1A1DA563B4ED1B1F crc64:AF4F1C80303A4E98 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:I7yqtuWuWgjiLFJcsU17mCtDs2Q559292 rogid:9/iGImP9/c8HSYwgmItME27z7lE559292 rigid:1i7qOcpmuYMdWNcKAyUiQraq4Kk false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P38431 uniprotkb:P32481 intact:EBI-9038|ensemblfungi:YPR041W|uniprotkb:D6W450 intact:EBI-8924|ensemblfungi:YER025W|uniprotkb:D3DLS4 psi-mi:if5_yeast(display_long)|uniprotkb:YP3085.05(orf name)|uniprotkb:YPR041W(locus name)|uniprotkb:TIF5(gene name)|psi-mi:TIF5(display_short) psi-mi:if2g_yeast(display_long)|uniprotkb:YER025W(locus name)|uniprotkb:GCD11(gene name)|psi-mi:GCD11(display_short)|uniprotkb:TIF213(gene name synonym)|uniprotkb:SUI4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jennings et al. (2010) pubmed:20485439|doi:10.1038/nature09003|imex:IM-16312 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15855936|imex:IM-16312-6|dip:DIP-187477E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YPR041W(gene)|ensemblfungi:YPR041W_mRNA(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|rcsb pdb:2FUL|rcsb pdb:6FYX|rcsb pdb:6FYY|rcsb pdb:6ZU9|reactome:R-SCE-72702|go:"GO:0045947"(negative regulation of translational initiation)|refseq:NP_015366.1|sgd:S000006245|mint:P38431|dip:DIP-2303N rcsb pdb:6I3M|rcsb pdb:6I7T|rcsb pdb:6QG0|rcsb pdb:6QG1|rcsb pdb:6QG2|rcsb pdb:6QG3|rcsb pdb:6QG5|rcsb pdb:6QG6|reactome:R-SCE-156827|reactome:R-SCE-381042|reactome:R-SCE-72649|reactome:R-SCE-72695|reactome:R-SCE-72702|reactome:R-SCE-72731|ensemblfungi:YER025W(gene)|ensemblfungi:YER025W_mRNA(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0045903"(positive regulation of translational fidelity)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR015256(Initiation factor eIF2 gamma, C terminal)|interpro:IPR027417|interpro:IPR044127|interpro:IPR044128|rcsb pdb:3J81|rcsb pdb:3JAP|rcsb pdb:3JAQ|rcsb pdb:4ZGN|rcsb pdb:4ZGQ|rcsb pdb:6FYX|rcsb pdb:6FYY|rcsb pdb:6GSM|rcsb pdb:6GSN|refseq:NP_010942.1|sgd:S000000827|mint:P32481|dip:DIP-2561N psi-mi:"MI:0465"(dip) crc64:1A1DA563B4ED1B1F crc64:D498AE62BC3E81CD full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:I7yqtuWuWgjiLFJcsU17mCtDs2Q559292 rogid:KLaBewFsp1tygK0+hirsBIaMPEI559292 rigid:1i7qOcpmuYMdWNcKAyUiQraq4Kk false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)