#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0ACB4	uniprotkb:P0ACB4	intact:EBI-1115706|uniprotkb:P27863|uniprotkb:Q2M8F3|ensemblbacteria:AAC76853|ensemblbacteria:BAE77453	intact:EBI-1115706|uniprotkb:P27863|uniprotkb:Q2M8F3|ensemblbacteria:AAC76853|ensemblbacteria:BAE77453	psi-mi:hemg_ecoli(display_long)|uniprotkb:Protoporphyrinogen IX dehydrogenase [menaquinone](gene name synonym)|uniprotkb:Protoporphyrinogen IX dehydrogenase [ubiquinone](gene name synonym)|uniprotkb:Protoporphyrinogen oxidase(gene name synonym)|uniprotkb:yihB(gene name synonym)|uniprotkb:hemG(gene name)|psi-mi:hemG(display_short)|uniprotkb:b3850(locus name)|uniprotkb:JW3827(locus name)	psi-mi:hemg_ecoli(display_long)|uniprotkb:Protoporphyrinogen IX dehydrogenase [menaquinone](gene name synonym)|uniprotkb:Protoporphyrinogen IX dehydrogenase [ubiquinone](gene name synonym)|uniprotkb:Protoporphyrinogen oxidase(gene name synonym)|uniprotkb:yihB(gene name synonym)|uniprotkb:hemG(gene name)|psi-mi:hemG(display_short)|uniprotkb:b3850(locus name)|uniprotkb:JW3827(locus name)	psi-mi:"MI:0071"(molecular sieving)	Möbius et al. (2010)	pubmed:20484676|doi:10.1073/pnas.1000956107|imex:IM-16420	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15855419|imex:IM-16420-1|dip:DIP-187635E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_000853959.1|ensemblbacteria:AAC76853(transcript)|ensemblbacteria:b3850(gene)|ensemblbacteria:BAE77453(gene)|ensemblbacteria:BAE77453(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0010181"(FMN binding)|go:"GO:0070819"(menaquinone-dependent protoporphyrinogen oxidase activity)|interpro:IPR001226(Flavodoxin, conserved site)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR026816|interpro:IPR029039|interpro:IPR044264|refseq:NP_418292.1|dip:DIP-35890N	refseq:WP_000853959.1|ensemblbacteria:AAC76853(transcript)|ensemblbacteria:b3850(gene)|ensemblbacteria:BAE77453(gene)|ensemblbacteria:BAE77453(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0010181"(FMN binding)|go:"GO:0070819"(menaquinone-dependent protoporphyrinogen oxidase activity)|interpro:IPR001226(Flavodoxin, conserved site)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR026816|interpro:IPR029039|interpro:IPR044264|refseq:NP_418292.1|dip:DIP-35890N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/06	2017/08/10	rogid:uyVtKvQ82ueC4uSJpg54d/rPB/s83333	rogid:uyVtKvQ82ueC4uSJpg54d/rPB/s83333	rigid:Fpxftuwlz5hOTz9J/PxmjAoDjLI	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00363	uniprotkb:P0ACB4	intact:EBI-550480|uniprotkb:Q2M6E8|ensemblbacteria:AAC77114|ensemblbacteria:BAE78158	intact:EBI-1115706|uniprotkb:P27863|uniprotkb:Q2M8F3|ensemblbacteria:AAC76853|ensemblbacteria:BAE77453	psi-mi:frda_ecoli(display_long)|uniprotkb:frdA(gene name)|psi-mi:frdA(display_short)|uniprotkb:Quinol-fumarate reductase flavoprotein subunit(gene name synonym)|uniprotkb:JW4115(locus name)|uniprotkb:b4154(locus name)	psi-mi:hemg_ecoli(display_long)|uniprotkb:Protoporphyrinogen IX dehydrogenase [menaquinone](gene name synonym)|uniprotkb:Protoporphyrinogen IX dehydrogenase [ubiquinone](gene name synonym)|uniprotkb:Protoporphyrinogen oxidase(gene name synonym)|uniprotkb:yihB(gene name synonym)|uniprotkb:hemG(gene name)|psi-mi:hemG(display_short)|uniprotkb:b3850(locus name)|uniprotkb:JW3827(locus name)	psi-mi:"MI:0226"(ion exchange chromatography)	Möbius et al. (2010)	pubmed:20484676|doi:10.1073/pnas.1000956107|imex:IM-16420	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15855435|imex:IM-16420-2|dip:DIP-187636E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_418578.1|refseq:WP_001192973.1|dip:DIP-9681N|ensemblbacteria:AAC77114(transcript)|ensemblbacteria:b4154(gene)|ensemblbacteria:BAE78158(gene)|ensemblbacteria:BAE78158(transcript)|go:"GO:0000104"(succinate dehydrogenase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006113"(fermentation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009061"(anaerobic respiration)|go:"GO:0016020"(membrane)|go:"GO:0044780"(bacterial-type flagellum assembly)|go:"GO:0045284"(plasma membrane fumarate reductase complex)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0071949"(FAD binding)|go:"GO:0071973"(bacterial-type flagellum-dependent cell motility)|go:"GO:0102040"("fumarate reductase (menaquinone)")|interpro:IPR003952(Fumarate reductase/succinate dehydrogenase, FAD-binding site)|interpro:IPR003953(Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal)|interpro:IPR005884(Fumarate reductase, flavoprotein subunit)|interpro:IPR011280(Succinate dehydrogenase/fumarate reductase, flavoprotein subunit, low-GC Gram-positive bacteria)|interpro:IPR014006(Succinate dehydrogenase or fumarate reductase, flavoprotein subunit)|interpro:IPR015939(Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal)|interpro:IPR027477|interpro:IPR036188|interpro:IPR037099|rcsb pdb:1KF6|rcsb pdb:1KFY|rcsb pdb:1L0V|rcsb pdb:2B76|rcsb pdb:3CIR|rcsb pdb:3P4P|rcsb pdb:3P4Q|rcsb pdb:3P4R|rcsb pdb:3P4S|rcsb pdb:4KX6|rcsb pdb:5VPN|rcsb pdb:6AWF|rcsb pdb:6B58	refseq:WP_000853959.1|ensemblbacteria:AAC76853(transcript)|ensemblbacteria:b3850(gene)|ensemblbacteria:BAE77453(gene)|ensemblbacteria:BAE77453(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0010181"(FMN binding)|go:"GO:0070819"(menaquinone-dependent protoporphyrinogen oxidase activity)|interpro:IPR001226(Flavodoxin, conserved site)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR026816|interpro:IPR029039|interpro:IPR044264|refseq:NP_418292.1|dip:DIP-35890N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/06	2017/08/10	rogid:7SLK6ZQyU/99f/hv5R8G6fEojt883333	rogid:uyVtKvQ82ueC4uSJpg54d/rPB/s83333	rigid:Opt0LdWer7jVl84/9aCfg973IuM	false	-	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:P00363	uniprotkb:P0ACB4	intact:EBI-550480|uniprotkb:Q2M6E8|ensemblbacteria:AAC77114|ensemblbacteria:BAE78158	intact:EBI-1115706|uniprotkb:P27863|uniprotkb:Q2M8F3|ensemblbacteria:AAC76853|ensemblbacteria:BAE77453	psi-mi:frda_ecoli(display_long)|uniprotkb:frdA(gene name)|psi-mi:frdA(display_short)|uniprotkb:Quinol-fumarate reductase flavoprotein subunit(gene name synonym)|uniprotkb:JW4115(locus name)|uniprotkb:b4154(locus name)	psi-mi:hemg_ecoli(display_long)|uniprotkb:Protoporphyrinogen IX dehydrogenase [menaquinone](gene name synonym)|uniprotkb:Protoporphyrinogen IX dehydrogenase [ubiquinone](gene name synonym)|uniprotkb:Protoporphyrinogen oxidase(gene name synonym)|uniprotkb:yihB(gene name synonym)|uniprotkb:hemG(gene name)|psi-mi:hemG(display_short)|uniprotkb:b3850(locus name)|uniprotkb:JW3827(locus name)	psi-mi:"MI:0096"(pull down)	Möbius et al. (2010)	pubmed:20484676|doi:10.1073/pnas.1000956107|imex:IM-16420	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15855452|imex:IM-16420-3|dip:DIP-187636E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_418578.1|refseq:WP_001192973.1|dip:DIP-9681N|ensemblbacteria:AAC77114(transcript)|ensemblbacteria:b4154(gene)|ensemblbacteria:BAE78158(gene)|ensemblbacteria:BAE78158(transcript)|go:"GO:0000104"(succinate dehydrogenase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006113"(fermentation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009061"(anaerobic respiration)|go:"GO:0016020"(membrane)|go:"GO:0044780"(bacterial-type flagellum assembly)|go:"GO:0045284"(plasma membrane fumarate reductase complex)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0071949"(FAD binding)|go:"GO:0071973"(bacterial-type flagellum-dependent cell motility)|go:"GO:0102040"("fumarate reductase (menaquinone)")|interpro:IPR003952(Fumarate reductase/succinate dehydrogenase, FAD-binding site)|interpro:IPR003953(Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal)|interpro:IPR005884(Fumarate reductase, flavoprotein subunit)|interpro:IPR011280(Succinate dehydrogenase/fumarate reductase, flavoprotein subunit, low-GC Gram-positive bacteria)|interpro:IPR014006(Succinate dehydrogenase or fumarate reductase, flavoprotein subunit)|interpro:IPR015939(Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal)|interpro:IPR027477|interpro:IPR036188|interpro:IPR037099|rcsb pdb:1KF6|rcsb pdb:1KFY|rcsb pdb:1L0V|rcsb pdb:2B76|rcsb pdb:3CIR|rcsb pdb:3P4P|rcsb pdb:3P4Q|rcsb pdb:3P4R|rcsb pdb:3P4S|rcsb pdb:4KX6|rcsb pdb:5VPN|rcsb pdb:6AWF|rcsb pdb:6B58	refseq:WP_000853959.1|ensemblbacteria:AAC76853(transcript)|ensemblbacteria:b3850(gene)|ensemblbacteria:BAE77453(gene)|ensemblbacteria:BAE77453(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0010181"(FMN binding)|go:"GO:0070819"(menaquinone-dependent protoporphyrinogen oxidase activity)|interpro:IPR001226(Flavodoxin, conserved site)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR026816|interpro:IPR029039|interpro:IPR044264|refseq:NP_418292.1|dip:DIP-35890N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/06	2017/08/10	rogid:7SLK6ZQyU/99f/hv5R8G6fEojt883333	rogid:uyVtKvQ82ueC4uSJpg54d/rPB/s83333	rigid:Opt0LdWer7jVl84/9aCfg973IuM	false	-	his tag:n-n	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)