#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P07949 uniprotkb:P07949 intact:EBI-2480756|intact:EBI-28967738|ensembl:ENSP00000347942|uniprotkb:A8K6Z2|uniprotkb:Q9BTB0|uniprotkb:Q15250|uniprotkb:Q9H4A2 intact:EBI-2480756|intact:EBI-28967738|ensembl:ENSP00000347942|uniprotkb:A8K6Z2|uniprotkb:Q9BTB0|uniprotkb:Q15250|uniprotkb:Q9H4A2 psi-mi:ret_human(display_long)|uniprotkb:RET(gene name)|psi-mi:RET(display_short)|uniprotkb:CDHF12(gene name synonym)|uniprotkb:Cadherin family member 12(gene name synonym)|uniprotkb:Proto-oncogene c-Ret(gene name synonym)|uniprotkb:CDHR16(gene name synonym)|uniprotkb:PTC(gene name synonym)|uniprotkb:RET51(gene name synonym) psi-mi:ret_human(display_long)|uniprotkb:RET(gene name)|psi-mi:RET(display_short)|uniprotkb:CDHF12(gene name synonym)|uniprotkb:Cadherin family member 12(gene name synonym)|uniprotkb:Proto-oncogene c-Ret(gene name synonym)|uniprotkb:CDHR16(gene name synonym)|uniprotkb:PTC(gene name synonym)|uniprotkb:RET51(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Kjaer et al. (2010) pubmed:20473317|doi:10.1038/nsmb.1808|imex:IM-16064 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15854617|imex:IM-16064-1|dip:DIP-186914E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000165731(gene)|ensembl:ENST00000355710(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007497"(posterior midgut development)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002126(Cadherin)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015919(Cadherin-like)|interpro:IPR016249(Tyrosine-protein kinase, Ret receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR040667|interpro:IPR041163|interpro:IPR041317|go:"GO:0098797"(plasma membrane protein complex)|mint:P07949|rcsb pdb:1XPD|rcsb pdb:2IVS|rcsb pdb:2IVT|rcsb pdb:2IVU|rcsb pdb:2IVV|rcsb pdb:2X2K|rcsb pdb:2X2L|rcsb pdb:2X2M|rcsb pdb:2X2U|rcsb pdb:4CKI|go:"GO:0035799"(ureter maturation)|go:"GO:0035860"(glial cell-derived neurotrophic factor receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042493"|go:"GO:0042551"(neuron maturation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048265"(response to pain)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060384"(innervation)|go:"GO:0061146"(Peyer's patch morphogenesis)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072300"(positive regulation of metanephric glomerulus development)|go:"GO:0097021"(lymphocyte migration into lymphoid organs)|go:"GO:0033674"(positive regulation of kinase activity)|rcsb pdb:4UX8|rcsb pdb:5AMN|rcsb pdb:5FM2|rcsb pdb:5FM3|rcsb pdb:6FEK|rcsb pdb:6GL7|rcsb pdb:6I82|rcsb pdb:6I83|rcsb pdb:6NE7|rcsb pdb:6NEC|rcsb pdb:6NJA|rcsb pdb:6Q2J|rcsb pdb:6Q2N|rcsb pdb:6Q2O|rcsb pdb:6Q2R|rcsb pdb:4CKJ|rcsb pdb:6Q2S|rcsb pdb:6VHG|rcsb pdb:7JU5|rcsb pdb:7JU6|reactome:R-HSA-5673001|reactome:R-HSA-8853659|ensembl:ENST00000340058|ensembl:ENSP00000344798|ensembl:ENSP00000347942|refseq:NP_065681.1|refseq:NP_066124.1|dip:DIP-41449N ensembl:ENSG00000165731(gene)|ensembl:ENST00000355710(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007497"(posterior midgut development)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002126(Cadherin)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015919(Cadherin-like)|interpro:IPR016249(Tyrosine-protein kinase, Ret receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR040667|interpro:IPR041163|interpro:IPR041317|go:"GO:0098797"(plasma membrane protein complex)|mint:P07949|rcsb pdb:1XPD|rcsb pdb:2IVS|rcsb pdb:2IVT|rcsb pdb:2IVU|rcsb pdb:2IVV|rcsb pdb:2X2K|rcsb pdb:2X2L|rcsb pdb:2X2M|rcsb pdb:2X2U|rcsb pdb:4CKI|go:"GO:0035799"(ureter maturation)|go:"GO:0035860"(glial cell-derived neurotrophic factor receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042493"|go:"GO:0042551"(neuron maturation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048265"(response to pain)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060384"(innervation)|go:"GO:0061146"(Peyer's patch morphogenesis)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072300"(positive regulation of metanephric glomerulus development)|go:"GO:0097021"(lymphocyte migration into lymphoid organs)|go:"GO:0033674"(positive regulation of kinase activity)|rcsb pdb:4UX8|rcsb pdb:5AMN|rcsb pdb:5FM2|rcsb pdb:5FM3|rcsb pdb:6FEK|rcsb pdb:6GL7|rcsb pdb:6I82|rcsb pdb:6I83|rcsb pdb:6NE7|rcsb pdb:6NEC|rcsb pdb:6NJA|rcsb pdb:6Q2J|rcsb pdb:6Q2N|rcsb pdb:6Q2O|rcsb pdb:6Q2R|rcsb pdb:4CKJ|rcsb pdb:6Q2S|rcsb pdb:6VHG|rcsb pdb:7JU5|rcsb pdb:7JU6|reactome:R-HSA-5673001|reactome:R-HSA-8853659|ensembl:ENST00000340058|ensembl:ENSP00000344798|ensembl:ENSP00000347942|refseq:NP_065681.1|refseq:NP_066124.1|dip:DIP-41449N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") - 2017/08/06 2017/08/10 rogid:vNKdBK5ZYchweyidTdbDFkd02VM9606 rogid:vNKdBK5ZYchweyidTdbDFkd02VM9606 rigid:ZxPV2R9rThqKvPykmep83XmV8M8 false binding-associated region:1-272 binding-associated region:1-272 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P56159-2 uniprotkb:P07949 intact:EBI-15854635|ensembl:ENSP00000358239|ensembl:ENSP00000393725|ensembl:ENSP00000506818|ensembl:ENSP00000507970 intact:EBI-2480756|intact:EBI-28967738|ensembl:ENSP00000347942|uniprotkb:A8K6Z2|uniprotkb:Q9BTB0|uniprotkb:Q15250|uniprotkb:Q9H4A2 psi-mi:p56159-2(display_long)|uniprotkb:GFRA1(gene name)|psi-mi:GFRA1(display_short)|uniprotkb:GDNFRA(gene name synonym)|uniprotkb:RETL1(gene name synonym)|uniprotkb:TRNR1(gene name synonym)|uniprotkb:RET ligand 1(gene name synonym)|uniprotkb:TGF-beta-related neurotrophic factor receptor 1(gene name synonym) psi-mi:ret_human(display_long)|uniprotkb:RET(gene name)|psi-mi:RET(display_short)|uniprotkb:CDHF12(gene name synonym)|uniprotkb:Cadherin family member 12(gene name synonym)|uniprotkb:Proto-oncogene c-Ret(gene name synonym)|uniprotkb:CDHR16(gene name synonym)|uniprotkb:PTC(gene name synonym)|uniprotkb:RET51(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Kjaer et al. (2010) pubmed:20473317|doi:10.1038/nsmb.1808|imex:IM-16064 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15854646|imex:IM-16064-2|dip:DIP-186915E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-3909401(isoform-parent)|ensembl:ENSG00000151892(gene)|ensembl:ENST00000369236(transcript)|ensembl:ENST00000439649(transcript)|ensembl:ENST00000682743(transcript)|ensembl:ENST00000684105(transcript) ensembl:ENSG00000165731(gene)|ensembl:ENST00000355710(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007497"(posterior midgut development)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002126(Cadherin)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015919(Cadherin-like)|interpro:IPR016249(Tyrosine-protein kinase, Ret receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR040667|interpro:IPR041163|interpro:IPR041317|go:"GO:0098797"(plasma membrane protein complex)|mint:P07949|rcsb pdb:1XPD|rcsb pdb:2IVS|rcsb pdb:2IVT|rcsb pdb:2IVU|rcsb pdb:2IVV|rcsb pdb:2X2K|rcsb pdb:2X2L|rcsb pdb:2X2M|rcsb pdb:2X2U|rcsb pdb:4CKI|go:"GO:0035799"(ureter maturation)|go:"GO:0035860"(glial cell-derived neurotrophic factor receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042493"|go:"GO:0042551"(neuron maturation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048265"(response to pain)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060384"(innervation)|go:"GO:0061146"(Peyer's patch morphogenesis)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072300"(positive regulation of metanephric glomerulus development)|go:"GO:0097021"(lymphocyte migration into lymphoid organs)|go:"GO:0033674"(positive regulation of kinase activity)|rcsb pdb:4UX8|rcsb pdb:5AMN|rcsb pdb:5FM2|rcsb pdb:5FM3|rcsb pdb:6FEK|rcsb pdb:6GL7|rcsb pdb:6I82|rcsb pdb:6I83|rcsb pdb:6NE7|rcsb pdb:6NEC|rcsb pdb:6NJA|rcsb pdb:6Q2J|rcsb pdb:6Q2N|rcsb pdb:6Q2O|rcsb pdb:6Q2R|rcsb pdb:4CKJ|rcsb pdb:6Q2S|rcsb pdb:6VHG|rcsb pdb:7JU5|rcsb pdb:7JU6|reactome:R-HSA-5673001|reactome:R-HSA-8853659|ensembl:ENST00000340058|ensembl:ENSP00000344798|ensembl:ENSP00000347942|refseq:NP_065681.1|refseq:NP_066124.1|dip:DIP-41449N psi-mi:"MI:0465"(dip) isoform-comment:May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:Z++DYOLddWR6nL2gs83Qz5XC1509606 rogid:vNKdBK5ZYchweyidTdbDFkd02VM9606 rigid:aimKKaYj52sNaN8q7YSqHNU5ZTI false binding-associated region:19-429 binding-associated region:1-636|mutation decreasing interaction:77-77,144-144 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P39905-1 uniprotkb:P56159-2 intact:EBI-15854671|ensembl:ENSP00000317145 intact:EBI-15854635|ensembl:ENSP00000358239|ensembl:ENSP00000393725|ensembl:ENSP00000506818|ensembl:ENSP00000507970 psi-mi:p39905-1(display_long)|uniprotkb:GDNF(gene name)|psi-mi:GDNF(display_short)|uniprotkb:Astrocyte-derived trophic factor(gene name synonym)|uniprotkb:Ex1_4L(isoform synonym) psi-mi:p56159-2(display_long)|uniprotkb:GFRA1(gene name)|psi-mi:GFRA1(display_short)|uniprotkb:GDNFRA(gene name synonym)|uniprotkb:RETL1(gene name synonym)|uniprotkb:TRNR1(gene name synonym)|uniprotkb:RET ligand 1(gene name synonym)|uniprotkb:TGF-beta-related neurotrophic factor receptor 1(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Kjaer et al. (2010) pubmed:20473317|doi:10.1038/nsmb.1808|imex:IM-16064 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15854678|imex:IM-16064-3|dip:DIP-186916E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000168621(gene)|ensembl:ENST00000326524(transcript)|intact:EBI-10207709(isoform-parent) intact:EBI-3909401(isoform-parent)|ensembl:ENSG00000151892(gene)|ensembl:ENST00000369236(transcript)|ensembl:ENST00000439649(transcript)|ensembl:ENST00000682743(transcript)|ensembl:ENST00000684105(transcript) psi-mi:"MI:0465"(dip) - isoform-comment:May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:6BX5EdPyEXXLMF6zHRYglDOyeyc9606 rogid:Z++DYOLddWR6nL2gs83Qz5XC1509606 rigid:DJrcnLCZay35ikv3XTN4aA8SylY false binding-associated region:109-211 binding-associated region:19-429 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)