#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O88509	uniprotkb:O75461	intact:EBI-7987547|intact:MINT-2523761|uniprotkb:O88510|uniprotkb:O88511|ensembl:ENSMUSP00000072761|ensembl:ENSMUSP00000105396	intact:EBI-749694|uniprotkb:O60544|uniprotkb:Q53QY9|uniprotkb:Q7Z2H6|uniprotkb:A8K2Z8|uniprotkb:G5E936|uniprotkb:Q6Q9Z6|ensembl:ENSP00000370936	psi-mi:dnm3b_mouse(display_long)|uniprotkb:Dnmt3b(gene name)|psi-mi:Dnmt3b(display_short)|uniprotkb:DNA methyltransferase MmuIIIB(gene name synonym)	psi-mi:e2f6_human(display_long)|uniprotkb:E2F6(gene name)|psi-mi:E2F6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Velasco et al. (2010)	pubmed:20439742|doi:10.1073/pnas.1000473107|imex:IM-16408	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15852517|imex:IM-16408-1|dip:DIP-187619E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001258676.1|refseq:NP_001003961.2|refseq:NP_001258674.1|refseq:NP_001003960.2|refseq:NP_034198.3|refseq:NP_001258673.1|dip:DIP-43736N|ensembl:ENSMUSG00000027478(gene)|ensembl:ENSMUST00000072997(transcript)|ensembl:ENSMUST00000109774(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051718"("DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates")|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0060821"(obsolete inactivation of X chromosome by DNA methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090116"(C-5 methylation of cytosine)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030488|interpro:IPR040552|mint:O88509|rcsb pdb:1KHC|reactome:R-MMU-212300|reactome:R-MMU-4655427	refseq:NP_001265204.1|refseq:NP_001265205.1|refseq:NP_001265206.1|refseq:NP_001265207.1|refseq:NP_937987.2|dip:DIP-41699N|ensembl:ENSG00000169016(gene)|ensembl:ENST00000381525(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|interpro:IPR015635(Transcription Factor E2F6)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|mint:O75461|reactome:R-HSA-69205|reactome:R-HSA-8953750|interpro:IPR032198	psi-mi:"MI:0465"(dip)	comment:mint|function:Required for genome wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:kyLQKXAetZyuwqBYP3+08/cb5JU10090	rogid:HZpQSfeASNNMLz4NCYOp6T0yXTk9606	rigid:6fxprwYFeYTpHtuxZ5XRgdHofzs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O88509	uniprotkb:O54917	intact:EBI-7987547|intact:MINT-2523761|uniprotkb:O88510|uniprotkb:O88511|ensembl:ENSMUSP00000072761|ensembl:ENSMUSP00000105396	intact:EBI-15852534|ensembl:ENSMUSP00000020908|uniprotkb:Q8K456	psi-mi:dnm3b_mouse(display_long)|uniprotkb:Dnmt3b(gene name)|psi-mi:Dnmt3b(display_short)|uniprotkb:DNA methyltransferase MmuIIIB(gene name synonym)	psi-mi:e2f6_mouse(display_long)|uniprotkb:E2f6(gene name)|psi-mi:E2f6(display_short)|uniprotkb:E2F-binding site-modulating activity protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Velasco et al. (2010)	pubmed:20439742|doi:10.1073/pnas.1000473107|imex:IM-16408	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15852561|imex:IM-16408-2|dip:DIP-187620E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001258676.1|refseq:NP_001003961.2|refseq:NP_001258674.1|refseq:NP_001003960.2|refseq:NP_034198.3|refseq:NP_001258673.1|dip:DIP-43736N|ensembl:ENSMUSG00000027478(gene)|ensembl:ENSMUST00000072997(transcript)|ensembl:ENSMUST00000109774(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051718"("DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates")|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0060821"(obsolete inactivation of X chromosome by DNA methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090116"(C-5 methylation of cytosine)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030488|interpro:IPR040552|mint:O88509|rcsb pdb:1KHC|reactome:R-MMU-212300|reactome:R-MMU-4655427	ensembl:ENSMUSG00000057469(gene)|ensembl:ENSMUST00000020908(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|interpro:IPR015635(Transcription Factor E2F6)|interpro:IPR032198|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|reactome:R-MMU-8953750|refseq:NP_150373.2|dip:DIP-59331N	psi-mi:"MI:0465"(dip)	comment:mint|function:Required for genome wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:kyLQKXAetZyuwqBYP3+08/cb5JU10090	rogid:yzwWkbzEzdlzzfimtL9/Zc43EIg10090	rigid:7JFpVecZgVgtYzLpDvN0lDOkBWk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)