#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P97438	uniprotkb:Q6PHU5	intact:EBI-7091062|ensembl:ENSMUSP00000141891|intact:MINT-4050407|uniprotkb:Q4VQI2	intact:EBI-6985663|ensembl:ENSMUSP00000099692|uniprotkb:Q9QXW6|uniprotkb:A2AEE8|uniprotkb:Q8K043|uniprotkb:Q3UHE2|intact:MINT-4130555	psi-mi:kcnk2_mouse(display_long)|uniprotkb:Kcnk2(gene name)|psi-mi:Kcnk2(display_short)|uniprotkb:Outward rectifying potassium channel protein TREK-1(gene name synonym)|uniprotkb:"TREK-1 K(+) channel subunit"(gene name synonym)|uniprotkb:Two pore potassium channel TPKC1(gene name synonym)	psi-mi:sort_mouse(display_long)|uniprotkb:Sort1(gene name)|psi-mi:Sort1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mazella et al. (2010)	pubmed:20405001|doi:10.1371/journal.pbio.1000355|imex:IM-15205	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15850443|imex:IM-15205-1|dip:DIP-185644E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000037624(gene)|ensembl:ENSMUST00000193319(transcript)|go:"GO:0003231"(cardiac ventricle development)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007613"(memory)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0022841"(potassium ion leak channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0030424"(axon)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043679"(axon terminus)|go:"GO:0044305"(calyx of Held)|go:"GO:0048678"(response to axon injury)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0090102"(cochlea development)|go:"GO:0097449"(astrocyte projection)|go:"GO:1900039"(positive regulation of cellular response to hypoxia)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR003280(Potassium channel, two pore-domain)|interpro:IPR003976(Potassium channel, two pore-domain, TREK)|interpro:IPR013099(Ion transport 2)|mint:P97438|rcsb pdb:6CQ6|rcsb pdb:6CQ8|rcsb pdb:6CQ9|rcsb pdb:6V36|rcsb pdb:6V37|rcsb pdb:6V3C|rcsb pdb:6V3I|rcsb pdb:6W7B|rcsb pdb:6W7C|rcsb pdb:6W7D|rcsb pdb:6W7E|rcsb pdb:6W82|rcsb pdb:6W83|rcsb pdb:6W84|rcsb pdb:6W85|rcsb pdb:6W86|rcsb pdb:6W87|rcsb pdb:6W88|rcsb pdb:6W8A|rcsb pdb:6W8C|rcsb pdb:6W8F|reactome:R-MMU-5576886|reactome:R-MMU-1299503|refseq:NP_034737.2|refseq:NP_001153322.1|dip:DIP-58579N	ensembl:ENSMUSG00000068747(gene)|ensembl:ENSMUST00000102632(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|rcsb pdb:5ZNN|reactome:R-MMU-432722|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q6PHU5|rcsb pdb:5NMR|rcsb pdb:5NMT|rcsb pdb:5NNI|rcsb pdb:5NNJ|refseq:NP_064356.2|refseq:NP_001258528.1|dip:DIP-46095N	psi-mi:"MI:0465"(dip)	comment:mint	function:"Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi"|comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:njcSGBK1p+GNR86j7GFhMYREcMs10090	rogid:YWk1GufR/sfGvpibzo3UOxenP7s10090	rigid:gEPLd+YKfPwVsrfhaqo34mW/b/4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97438	uniprotkb:Q6PHU5	intact:EBI-7091062|ensembl:ENSMUSP00000141891|intact:MINT-4050407|uniprotkb:Q4VQI2	intact:EBI-6985663|ensembl:ENSMUSP00000099692|uniprotkb:Q9QXW6|uniprotkb:A2AEE8|uniprotkb:Q8K043|uniprotkb:Q3UHE2|intact:MINT-4130555	psi-mi:kcnk2_mouse(display_long)|uniprotkb:Kcnk2(gene name)|psi-mi:Kcnk2(display_short)|uniprotkb:Outward rectifying potassium channel protein TREK-1(gene name synonym)|uniprotkb:"TREK-1 K(+) channel subunit"(gene name synonym)|uniprotkb:Two pore potassium channel TPKC1(gene name synonym)	psi-mi:sort_mouse(display_long)|uniprotkb:Sort1(gene name)|psi-mi:Sort1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mazella et al. (2010)	pubmed:20405001|doi:10.1371/journal.pbio.1000355|imex:IM-15205	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15850477|imex:IM-15205-3|dip:DIP-185644E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000037624(gene)|ensembl:ENSMUST00000193319(transcript)|go:"GO:0003231"(cardiac ventricle development)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007613"(memory)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0022841"(potassium ion leak channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0030424"(axon)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043679"(axon terminus)|go:"GO:0044305"(calyx of Held)|go:"GO:0048678"(response to axon injury)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0090102"(cochlea development)|go:"GO:0097449"(astrocyte projection)|go:"GO:1900039"(positive regulation of cellular response to hypoxia)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR003280(Potassium channel, two pore-domain)|interpro:IPR003976(Potassium channel, two pore-domain, TREK)|interpro:IPR013099(Ion transport 2)|mint:P97438|rcsb pdb:6CQ6|rcsb pdb:6CQ8|rcsb pdb:6CQ9|rcsb pdb:6V36|rcsb pdb:6V37|rcsb pdb:6V3C|rcsb pdb:6V3I|rcsb pdb:6W7B|rcsb pdb:6W7C|rcsb pdb:6W7D|rcsb pdb:6W7E|rcsb pdb:6W82|rcsb pdb:6W83|rcsb pdb:6W84|rcsb pdb:6W85|rcsb pdb:6W86|rcsb pdb:6W87|rcsb pdb:6W88|rcsb pdb:6W8A|rcsb pdb:6W8C|rcsb pdb:6W8F|reactome:R-MMU-5576886|reactome:R-MMU-1299503|refseq:NP_034737.2|refseq:NP_001153322.1|dip:DIP-58579N	ensembl:ENSMUSG00000068747(gene)|ensembl:ENSMUST00000102632(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|rcsb pdb:5ZNN|reactome:R-MMU-432722|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q6PHU5|rcsb pdb:5NMR|rcsb pdb:5NMT|rcsb pdb:5NNI|rcsb pdb:5NNJ|refseq:NP_064356.2|refseq:NP_001258528.1|dip:DIP-46095N	psi-mi:"MI:0465"(dip)	comment:mint	function:"Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi"|comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:njcSGBK1p+GNR86j7GFhMYREcMs10090	rogid:YWk1GufR/sfGvpibzo3UOxenP7s10090	rigid:gEPLd+YKfPwVsrfhaqo34mW/b/4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97438	uniprotkb:Q6PHU5	intact:EBI-7091062|ensembl:ENSMUSP00000141891|intact:MINT-4050407|uniprotkb:Q4VQI2	intact:EBI-6985663|ensembl:ENSMUSP00000099692|uniprotkb:Q9QXW6|uniprotkb:A2AEE8|uniprotkb:Q8K043|uniprotkb:Q3UHE2|intact:MINT-4130555	psi-mi:kcnk2_mouse(display_long)|uniprotkb:Kcnk2(gene name)|psi-mi:Kcnk2(display_short)|uniprotkb:Outward rectifying potassium channel protein TREK-1(gene name synonym)|uniprotkb:"TREK-1 K(+) channel subunit"(gene name synonym)|uniprotkb:Two pore potassium channel TPKC1(gene name synonym)	psi-mi:sort_mouse(display_long)|uniprotkb:Sort1(gene name)|psi-mi:Sort1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mazella et al. (2010)	pubmed:20405001|doi:10.1371/journal.pbio.1000355|imex:IM-15205	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15850460|imex:IM-15205-2|dip:DIP-185644E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000037624(gene)|ensembl:ENSMUST00000193319(transcript)|go:"GO:0003231"(cardiac ventricle development)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007613"(memory)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0022841"(potassium ion leak channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0030424"(axon)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043679"(axon terminus)|go:"GO:0044305"(calyx of Held)|go:"GO:0048678"(response to axon injury)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0090102"(cochlea development)|go:"GO:0097449"(astrocyte projection)|go:"GO:1900039"(positive regulation of cellular response to hypoxia)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR003280(Potassium channel, two pore-domain)|interpro:IPR003976(Potassium channel, two pore-domain, TREK)|interpro:IPR013099(Ion transport 2)|mint:P97438|rcsb pdb:6CQ6|rcsb pdb:6CQ8|rcsb pdb:6CQ9|rcsb pdb:6V36|rcsb pdb:6V37|rcsb pdb:6V3C|rcsb pdb:6V3I|rcsb pdb:6W7B|rcsb pdb:6W7C|rcsb pdb:6W7D|rcsb pdb:6W7E|rcsb pdb:6W82|rcsb pdb:6W83|rcsb pdb:6W84|rcsb pdb:6W85|rcsb pdb:6W86|rcsb pdb:6W87|rcsb pdb:6W88|rcsb pdb:6W8A|rcsb pdb:6W8C|rcsb pdb:6W8F|reactome:R-MMU-5576886|reactome:R-MMU-1299503|refseq:NP_034737.2|refseq:NP_001153322.1|dip:DIP-58579N	ensembl:ENSMUSG00000068747(gene)|ensembl:ENSMUST00000102632(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|rcsb pdb:5ZNN|reactome:R-MMU-432722|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q6PHU5|rcsb pdb:5NMR|rcsb pdb:5NMT|rcsb pdb:5NNI|rcsb pdb:5NNJ|refseq:NP_064356.2|refseq:NP_001258528.1|dip:DIP-46095N	psi-mi:"MI:0465"(dip)	comment:mint	function:"Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi"|comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/06	2017/08/10	rogid:njcSGBK1p+GNR86j7GFhMYREcMs10090	rogid:YWk1GufR/sfGvpibzo3UOxenP7s10090	rigid:gEPLd+YKfPwVsrfhaqo34mW/b/4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97438	uniprotkb:Q6PHU5	intact:EBI-7091062|ensembl:ENSMUSP00000141891|intact:MINT-4050407|uniprotkb:Q4VQI2	intact:EBI-6985663|ensembl:ENSMUSP00000099692|uniprotkb:Q9QXW6|uniprotkb:A2AEE8|uniprotkb:Q8K043|uniprotkb:Q3UHE2|intact:MINT-4130555	psi-mi:kcnk2_mouse(display_long)|uniprotkb:Kcnk2(gene name)|psi-mi:Kcnk2(display_short)|uniprotkb:Outward rectifying potassium channel protein TREK-1(gene name synonym)|uniprotkb:"TREK-1 K(+) channel subunit"(gene name synonym)|uniprotkb:Two pore potassium channel TPKC1(gene name synonym)	psi-mi:sort_mouse(display_long)|uniprotkb:Sort1(gene name)|psi-mi:Sort1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mazella et al. (2010)	pubmed:20405001|doi:10.1371/journal.pbio.1000355|imex:IM-15205	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15850494|imex:IM-15205-4|dip:DIP-185644E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000037624(gene)|ensembl:ENSMUST00000193319(transcript)|go:"GO:0003231"(cardiac ventricle development)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007613"(memory)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0022841"(potassium ion leak channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0030424"(axon)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043679"(axon terminus)|go:"GO:0044305"(calyx of Held)|go:"GO:0048678"(response to axon injury)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0090102"(cochlea development)|go:"GO:0097449"(astrocyte projection)|go:"GO:1900039"(positive regulation of cellular response to hypoxia)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR003280(Potassium channel, two pore-domain)|interpro:IPR003976(Potassium channel, two pore-domain, TREK)|interpro:IPR013099(Ion transport 2)|mint:P97438|rcsb pdb:6CQ6|rcsb pdb:6CQ8|rcsb pdb:6CQ9|rcsb pdb:6V36|rcsb pdb:6V37|rcsb pdb:6V3C|rcsb pdb:6V3I|rcsb pdb:6W7B|rcsb pdb:6W7C|rcsb pdb:6W7D|rcsb pdb:6W7E|rcsb pdb:6W82|rcsb pdb:6W83|rcsb pdb:6W84|rcsb pdb:6W85|rcsb pdb:6W86|rcsb pdb:6W87|rcsb pdb:6W88|rcsb pdb:6W8A|rcsb pdb:6W8C|rcsb pdb:6W8F|reactome:R-MMU-5576886|reactome:R-MMU-1299503|refseq:NP_034737.2|refseq:NP_001153322.1|dip:DIP-58579N	ensembl:ENSMUSG00000068747(gene)|ensembl:ENSMUST00000102632(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|rcsb pdb:5ZNN|reactome:R-MMU-432722|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q6PHU5|rcsb pdb:5NMR|rcsb pdb:5NMT|rcsb pdb:5NNI|rcsb pdb:5NNJ|refseq:NP_064356.2|refseq:NP_001258528.1|dip:DIP-46095N	psi-mi:"MI:0465"(dip)	comment:mint	function:"Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi"|comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/06	2017/08/10	rogid:njcSGBK1p+GNR86j7GFhMYREcMs10090	rogid:YWk1GufR/sfGvpibzo3UOxenP7s10090	rigid:gEPLd+YKfPwVsrfhaqo34mW/b/4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)