#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q1PHM6	uniprotkb:P01730	intact:EBI-15845606	intact:EBI-353826|uniprotkb:Q4ZGK2|uniprotkb:Q5U066|uniprotkb:Q9UDE5|uniprotkb:B2R737|uniprotkb:D3DUS5|ensembl:ENSP00000011653	psi-mi:q1phm6_9hiv1(display_long)|uniprotkb:Env polyprotein(gene name synonym)|uniprotkb:env(gene name)|psi-mi:env(display_short)	psi-mi:cd4_human(display_long)|uniprotkb:CD4(gene name)|psi-mi:CD4(display_short)|uniprotkb:T-cell surface antigen T4/Leu-3(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Diskin et al. (2010)	pubmed:20357769|doi:10.1038/nsmb.1796|imex:IM-15947	taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15845623|imex:IM-15947-1|dip:DIP-186369E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005198"(structural molecule activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:3LQA|go:"GO:0016021"(integral component of membrane)|dip:DIP-58999N	refseq:NP_000607.1|rcsb pdb:1CDI|rcsb pdb:1CDJ|rcsb pdb:1CDU|rcsb pdb:1CDY|rcsb pdb:1G9M|rcsb pdb:1G9N|rcsb pdb:1GC1|rcsb pdb:1JL4|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1Q68|rcsb pdb:1RZJ|rcsb pdb:1RZK|rcsb pdb:1WBR|rcsb pdb:1WIO|rcsb pdb:1WIP|rcsb pdb:1WIQ|rcsb pdb:2B4C|rcsb pdb:1CDH|rcsb pdb:2JKR|rcsb pdb:2JKT|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-202427|reactome:R-HSA-389948|reactome:R-HSA-449836|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENST00000011653(transcript)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000973(T-cell surface antigen CD4)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015274(CD4, extracellular)|interpro:IPR021963|interpro:IPR036179|mint:P01730|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005769"(early endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006948"(induction by virus of host cell-cell fusion)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035397"(helper T cell enhancement of adaptive immune response)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042011"(interleukin-16 binding)|go:"GO:0042012"(interleukin-16 receptor activity)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045058"(T cell selection)|go:"GO:0045121"(membrane raft)|rcsb pdb:2KLU|rcsb pdb:2NXY|rcsb pdb:2NXZ|rcsb pdb:2NY0|rcsb pdb:2NY1|rcsb pdb:2NY2|rcsb pdb:2NY3|rcsb pdb:2NY4|rcsb pdb:2NY5|rcsb pdb:2NY6|rcsb pdb:2QAD|rcsb pdb:3B71|rcsb pdb:3CD4|rcsb pdb:3J70|rcsb pdb:3JCB|rcsb pdb:3JCC|rcsb pdb:3JWD|rcsb pdb:3JWO|rcsb pdb:3LQA|rcsb pdb:3O2D|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4H8W|rcsb pdb:4JM2|rcsb pdb:4P9H|rcsb pdb:4Q6I|rcsb pdb:4R2G|rcsb pdb:4R4H|rcsb pdb:4RQS|rcsb pdb:5A7X|rcsb pdb:5A8H|rcsb pdb:5CAY|rcsb pdb:5THR|rcsb pdb:5U1F|rcsb pdb:5VN3|rcsb pdb:6CM3|rcsb pdb:6EDU|rcsb pdb:6L1Y|rcsb pdb:6MEO|rcsb pdb:6MET|rcsb pdb:6OPN|rcsb pdb:6OPO|rcsb pdb:6OPP|rcsb pdb:6OPQ|rcsb pdb:6QH6|rcsb pdb:6QH7|rcsb pdb:6U0L|rcsb pdb:6U0N|rcsb pdb:6URI|rcsb pdb:6X5B|rcsb pdb:6X5C|reactome:R-HSA-1462054|reactome:R-HSA-167590|reactome:R-HSA-173107|reactome:R-HSA-180534|reactome:R-HSA-202424|ensembl:ENSG00000010610(gene)|dip:DIP-617N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:WYks1Dfc7ifc8L+HHnHQl/kNW4Q11676	rogid:twRRh+v4xPOIlmeD9jl+Jpqjle09606	rigid:ZdDgMXhhjYys4tNtXfabh9P39BU	false	polyprotein fragment:82-494	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q1PHM6	uniprotkb:P01730	intact:EBI-15845606	intact:EBI-353826|uniprotkb:Q4ZGK2|uniprotkb:Q5U066|uniprotkb:Q9UDE5|uniprotkb:B2R737|uniprotkb:D3DUS5|ensembl:ENSP00000011653	psi-mi:q1phm6_9hiv1(display_long)|uniprotkb:Env polyprotein(gene name synonym)|uniprotkb:env(gene name)|psi-mi:env(display_short)	psi-mi:cd4_human(display_long)|uniprotkb:CD4(gene name)|psi-mi:CD4(display_short)|uniprotkb:T-cell surface antigen T4/Leu-3(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Diskin et al. (2010)	pubmed:20357769|doi:10.1038/nsmb.1796|imex:IM-15947	taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15845642|imex:IM-15947-2|dip:DIP-186369E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005198"(structural molecule activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:3LQA|go:"GO:0016021"(integral component of membrane)|dip:DIP-58999N	refseq:NP_000607.1|rcsb pdb:1CDI|rcsb pdb:1CDJ|rcsb pdb:1CDU|rcsb pdb:1CDY|rcsb pdb:1G9M|rcsb pdb:1G9N|rcsb pdb:1GC1|rcsb pdb:1JL4|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1Q68|rcsb pdb:1RZJ|rcsb pdb:1RZK|rcsb pdb:1WBR|rcsb pdb:1WIO|rcsb pdb:1WIP|rcsb pdb:1WIQ|rcsb pdb:2B4C|rcsb pdb:1CDH|rcsb pdb:2JKR|rcsb pdb:2JKT|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-202427|reactome:R-HSA-389948|reactome:R-HSA-449836|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENST00000011653(transcript)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000973(T-cell surface antigen CD4)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015274(CD4, extracellular)|interpro:IPR021963|interpro:IPR036179|mint:P01730|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005769"(early endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006948"(induction by virus of host cell-cell fusion)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035397"(helper T cell enhancement of adaptive immune response)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042011"(interleukin-16 binding)|go:"GO:0042012"(interleukin-16 receptor activity)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045058"(T cell selection)|go:"GO:0045121"(membrane raft)|rcsb pdb:2KLU|rcsb pdb:2NXY|rcsb pdb:2NXZ|rcsb pdb:2NY0|rcsb pdb:2NY1|rcsb pdb:2NY2|rcsb pdb:2NY3|rcsb pdb:2NY4|rcsb pdb:2NY5|rcsb pdb:2NY6|rcsb pdb:2QAD|rcsb pdb:3B71|rcsb pdb:3CD4|rcsb pdb:3J70|rcsb pdb:3JCB|rcsb pdb:3JCC|rcsb pdb:3JWD|rcsb pdb:3JWO|rcsb pdb:3LQA|rcsb pdb:3O2D|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4H8W|rcsb pdb:4JM2|rcsb pdb:4P9H|rcsb pdb:4Q6I|rcsb pdb:4R2G|rcsb pdb:4R4H|rcsb pdb:4RQS|rcsb pdb:5A7X|rcsb pdb:5A8H|rcsb pdb:5CAY|rcsb pdb:5THR|rcsb pdb:5U1F|rcsb pdb:5VN3|rcsb pdb:6CM3|rcsb pdb:6EDU|rcsb pdb:6L1Y|rcsb pdb:6MEO|rcsb pdb:6MET|rcsb pdb:6OPN|rcsb pdb:6OPO|rcsb pdb:6OPP|rcsb pdb:6OPQ|rcsb pdb:6QH6|rcsb pdb:6QH7|rcsb pdb:6U0L|rcsb pdb:6U0N|rcsb pdb:6URI|rcsb pdb:6X5B|rcsb pdb:6X5C|reactome:R-HSA-1462054|reactome:R-HSA-167590|reactome:R-HSA-173107|reactome:R-HSA-180534|reactome:R-HSA-202424|ensembl:ENSG00000010610(gene)|dip:DIP-617N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:WYks1Dfc7ifc8L+HHnHQl/kNW4Q11676	rogid:twRRh+v4xPOIlmeD9jl+Jpqjle09606	rigid:ZdDgMXhhjYys4tNtXfabh9P39BU	false	polyprotein fragment:82-494	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)