#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P02749	uniprotkb:P01130	intact:EBI-2114682|uniprotkb:Q9UCN7|uniprotkb:B2R9M3|ensembl:ENSP00000205948	intact:EBI-988319|uniprotkb:Q53ZD9|ensembl:ENSP00000454071|uniprotkb:C0JYY8|uniprotkb:Q9UDH7|uniprotkb:B4DJZ8|uniprotkb:B4DR00|uniprotkb:B4DTQ3|uniprotkb:H0YLU8|uniprotkb:Q59FQ1|uniprotkb:B4DII3|uniprotkb:H0YNT7	psi-mi:apoh_human(display_long)|uniprotkb:APOH(gene name)|psi-mi:APOH(display_short)|uniprotkb:B2G1(gene name synonym)|uniprotkb:Beta-2-glycoprotein I(gene name synonym)|uniprotkb:Apolipoprotein H(gene name synonym)|uniprotkb:Activated protein C-binding protein(gene name synonym)|uniprotkb:APC inhibitor(gene name synonym)|uniprotkb:Anticardiolipin cofactor(gene name synonym)	psi-mi:ldlr_human(display_long)|uniprotkb:LDLR(gene name)|psi-mi:LDLR(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Lee et al. (2010)	pubmed:20223219|doi:10.1016/j.str.2009.12.013|imex:IM-15912	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15842181|imex:IM-15912-1|dip:DIP-186298E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000033.2|dip:DIP-46878N|ensembl:ENSG00000091583(gene)|ensembl:ENST00000205948(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007597"(blood coagulation, intrinsic pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0031639"(plasminogen activation)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042627"(chylomicron)|go:"GO:0042802"(identical protein binding)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051917"(regulation of fibrinolysis)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0060230"(lipoprotein lipase activator activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR015104(Beta-2-glycoprotein-1 fifth domain)|interpro:IPR035976|mint:P02749|rcsb pdb:1C1Z|rcsb pdb:1G4F|rcsb pdb:1G4G|rcsb pdb:1QUB|rcsb pdb:2KRI|rcsb pdb:3OP8|rcsb pdb:4JHS|rcsb pdb:6V06|rcsb pdb:6V08|rcsb pdb:6V09|reactome:R-HSA-114608	refseq:NP_000518.1|ensembl:ENSG00000130164(gene)|ensembl:ENST00000558518(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002020"(protease binding)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007616"(long-term memory)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010899"(regulation of phosphatidylcholine catabolic process)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070508"(cholesterol import)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097443"(sorting endosome)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990666"(PCSK9-LDLR complex)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|go:"GO:0030169"(low-density lipoprotein particle binding)|interpro:IPR036055|rcsb pdb:1AJJ|rcsb pdb:1D2J|rcsb pdb:1F5Y|rcsb pdb:1F8Z|rcsb pdb:1HJ7|rcsb pdb:1HZ8|rcsb pdb:1I0U|rcsb pdb:1IJQ|rcsb pdb:1LDL|mint:P01130|rcsb pdb:1LDR|rcsb pdb:1LRX|rcsb pdb:1N7D|rcsb pdb:1XFE|rcsb pdb:2FCW|rcsb pdb:2KRI|rcsb pdb:2LGP|rcsb pdb:2M7P|rcsb pdb:2MG9|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SO6|rcsb pdb:4NE9|rcsb pdb:5OY9|rcsb pdb:5OYL|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8964026|reactome:R-HSA-8964038|reactome:R-HSA-975634|rcsb pdb:2W2M|refseq:NP_001182732.1|refseq:NP_001182728.1|refseq:NP_001182729.1|refseq:NP_001182727.1|dip:DIP-29695N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:IcohvxbMLnnzWe0jmOC0/KVvP1Y9606	rogid:90JtkJet79Lm8v1cD6ggYERSrEM9606	rigid:fFuISsOO/ycLrm7idQkpxrKwwC4	false	binding-associated region:263-345|mutation disrupting interaction:336-336,327-327,301-301|mutation disrupting interaction:327-327,301-301	binding-associated region:86-122|binding-associated region:126-165	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q924X6	uniprotkb:P02749	intact:EBI-432319|uniprotkb:Q8CAK9|uniprotkb:Q8CDF5|uniprotkb:Q921B6|ensembl:ENSMUSP00000115854|ensembl:ENSMUSP00000158644	intact:EBI-2114682|uniprotkb:Q9UCN7|uniprotkb:B2R9M3|ensembl:ENSP00000205948	psi-mi:lrp8_mouse(display_long)|uniprotkb:Apolipoprotein E receptor 2(gene name synonym)|uniprotkb:Lrp8(gene name)|psi-mi:Lrp8(display_short)|uniprotkb:Apoer2(gene name synonym)	psi-mi:apoh_human(display_long)|uniprotkb:APOH(gene name)|psi-mi:APOH(display_short)|uniprotkb:B2G1(gene name synonym)|uniprotkb:Beta-2-glycoprotein I(gene name synonym)|uniprotkb:Apolipoprotein H(gene name synonym)|uniprotkb:Activated protein C-binding protein(gene name synonym)|uniprotkb:APC inhibitor(gene name synonym)|uniprotkb:Anticardiolipin cofactor(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Lee et al. (2010)	pubmed:20223219|doi:10.1016/j.str.2009.12.013|imex:IM-15912	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15842234|imex:IM-15912-3|dip:DIP-186299E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR036055|reactome:R-MMU-432142|interpro:IPR001881(EGF-like calcium-binding)|reactome:R-MMU-975634|go:"GO:0030425"(dendrite)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0038025"(reelin receptor activity)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:1900006"(positive regulation of dendrite development)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|refseq:XP_011238759.1|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021541"(ammon gyrus development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030424"(axon)|ensembl:ENSMUSG00000028613(gene)|ensembl:ENSMUST00000143601(transcript)|ensembl:ENSMUST00000238569(transcript)|go:"GO:0001540"(amyloid-beta binding)|dip:DIP-33284N	refseq:NP_000033.2|dip:DIP-46878N|ensembl:ENSG00000091583(gene)|ensembl:ENST00000205948(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007597"(blood coagulation, intrinsic pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0031639"(plasminogen activation)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042627"(chylomicron)|go:"GO:0042802"(identical protein binding)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051917"(regulation of fibrinolysis)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0060230"(lipoprotein lipase activator activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR015104(Beta-2-glycoprotein-1 fifth domain)|interpro:IPR035976|mint:P02749|rcsb pdb:1C1Z|rcsb pdb:1G4F|rcsb pdb:1G4G|rcsb pdb:1QUB|rcsb pdb:2KRI|rcsb pdb:3OP8|rcsb pdb:4JHS|rcsb pdb:6V06|rcsb pdb:6V08|rcsb pdb:6V09|reactome:R-HSA-114608	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:FB2l87dbS4aA0V7vavDO3HsBKq810090	rogid:IcohvxbMLnnzWe0jmOC0/KVvP1Y9606	rigid:FzyqXKBwc3ChUy1qxZAUhsc+4bk	false	binding-associated region:12-47|fluorescent dye label:?-?	binding-associated region:263-345	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q924X6	uniprotkb:P02749	intact:EBI-432319|uniprotkb:Q8CAK9|uniprotkb:Q8CDF5|uniprotkb:Q921B6|ensembl:ENSMUSP00000115854|ensembl:ENSMUSP00000158644	intact:EBI-2114682|uniprotkb:Q9UCN7|uniprotkb:B2R9M3|ensembl:ENSP00000205948	psi-mi:lrp8_mouse(display_long)|uniprotkb:Apolipoprotein E receptor 2(gene name synonym)|uniprotkb:Lrp8(gene name)|psi-mi:Lrp8(display_short)|uniprotkb:Apoer2(gene name synonym)	psi-mi:apoh_human(display_long)|uniprotkb:APOH(gene name)|psi-mi:APOH(display_short)|uniprotkb:B2G1(gene name synonym)|uniprotkb:Beta-2-glycoprotein I(gene name synonym)|uniprotkb:Apolipoprotein H(gene name synonym)|uniprotkb:Activated protein C-binding protein(gene name synonym)|uniprotkb:APC inhibitor(gene name synonym)|uniprotkb:Anticardiolipin cofactor(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Lee et al. (2010)	pubmed:20223219|doi:10.1016/j.str.2009.12.013|imex:IM-15912	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15842257|imex:IM-15912-4|dip:DIP-186299E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR036055|reactome:R-MMU-432142|interpro:IPR001881(EGF-like calcium-binding)|reactome:R-MMU-975634|go:"GO:0030425"(dendrite)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0038025"(reelin receptor activity)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:1900006"(positive regulation of dendrite development)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|refseq:XP_011238759.1|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021541"(ammon gyrus development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030424"(axon)|ensembl:ENSMUSG00000028613(gene)|ensembl:ENSMUST00000143601(transcript)|ensembl:ENSMUST00000238569(transcript)|go:"GO:0001540"(amyloid-beta binding)|dip:DIP-33284N	refseq:NP_000033.2|dip:DIP-46878N|ensembl:ENSG00000091583(gene)|ensembl:ENST00000205948(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007597"(blood coagulation, intrinsic pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0031639"(plasminogen activation)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042627"(chylomicron)|go:"GO:0042802"(identical protein binding)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051917"(regulation of fibrinolysis)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0060230"(lipoprotein lipase activator activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR015104(Beta-2-glycoprotein-1 fifth domain)|interpro:IPR035976|mint:P02749|rcsb pdb:1C1Z|rcsb pdb:1G4F|rcsb pdb:1G4G|rcsb pdb:1QUB|rcsb pdb:2KRI|rcsb pdb:3OP8|rcsb pdb:4JHS|rcsb pdb:6V06|rcsb pdb:6V08|rcsb pdb:6V09|reactome:R-HSA-114608	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:FB2l87dbS4aA0V7vavDO3HsBKq810090	rogid:IcohvxbMLnnzWe0jmOC0/KVvP1Y9606	rigid:FzyqXKBwc3ChUy1qxZAUhsc+4bk	false	binding-associated region:12-47	binding-associated region:263-345	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02749	uniprotkb:P01130	intact:EBI-2114682|uniprotkb:Q9UCN7|uniprotkb:B2R9M3|ensembl:ENSP00000205948	intact:EBI-988319|uniprotkb:Q53ZD9|ensembl:ENSP00000454071|uniprotkb:C0JYY8|uniprotkb:Q9UDH7|uniprotkb:B4DJZ8|uniprotkb:B4DR00|uniprotkb:B4DTQ3|uniprotkb:H0YLU8|uniprotkb:Q59FQ1|uniprotkb:B4DII3|uniprotkb:H0YNT7	psi-mi:apoh_human(display_long)|uniprotkb:APOH(gene name)|psi-mi:APOH(display_short)|uniprotkb:B2G1(gene name synonym)|uniprotkb:Beta-2-glycoprotein I(gene name synonym)|uniprotkb:Apolipoprotein H(gene name synonym)|uniprotkb:Activated protein C-binding protein(gene name synonym)|uniprotkb:APC inhibitor(gene name synonym)|uniprotkb:Anticardiolipin cofactor(gene name synonym)	psi-mi:ldlr_human(display_long)|uniprotkb:LDLR(gene name)|psi-mi:LDLR(display_short)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Lee et al. (2010)	pubmed:20223219|doi:10.1016/j.str.2009.12.013|imex:IM-15912	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15842213|imex:IM-15912-2|dip:DIP-186298E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000033.2|dip:DIP-46878N|ensembl:ENSG00000091583(gene)|ensembl:ENST00000205948(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007597"(blood coagulation, intrinsic pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0031639"(plasminogen activation)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042627"(chylomicron)|go:"GO:0042802"(identical protein binding)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051917"(regulation of fibrinolysis)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0060230"(lipoprotein lipase activator activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR015104(Beta-2-glycoprotein-1 fifth domain)|interpro:IPR035976|mint:P02749|rcsb pdb:1C1Z|rcsb pdb:1G4F|rcsb pdb:1G4G|rcsb pdb:1QUB|rcsb pdb:2KRI|rcsb pdb:3OP8|rcsb pdb:4JHS|rcsb pdb:6V06|rcsb pdb:6V08|rcsb pdb:6V09|reactome:R-HSA-114608	refseq:NP_000518.1|ensembl:ENSG00000130164(gene)|ensembl:ENST00000558518(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002020"(protease binding)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007616"(long-term memory)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010899"(regulation of phosphatidylcholine catabolic process)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070508"(cholesterol import)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097443"(sorting endosome)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990666"(PCSK9-LDLR complex)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|go:"GO:0030169"(low-density lipoprotein particle binding)|interpro:IPR036055|rcsb pdb:1AJJ|rcsb pdb:1D2J|rcsb pdb:1F5Y|rcsb pdb:1F8Z|rcsb pdb:1HJ7|rcsb pdb:1HZ8|rcsb pdb:1I0U|rcsb pdb:1IJQ|rcsb pdb:1LDL|mint:P01130|rcsb pdb:1LDR|rcsb pdb:1LRX|rcsb pdb:1N7D|rcsb pdb:1XFE|rcsb pdb:2FCW|rcsb pdb:2KRI|rcsb pdb:2LGP|rcsb pdb:2M7P|rcsb pdb:2MG9|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SO6|rcsb pdb:4NE9|rcsb pdb:5OY9|rcsb pdb:5OYL|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8964026|reactome:R-HSA-8964038|reactome:R-HSA-975634|rcsb pdb:2W2M|refseq:NP_001182732.1|refseq:NP_001182728.1|refseq:NP_001182729.1|refseq:NP_001182727.1|dip:DIP-29695N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:IcohvxbMLnnzWe0jmOC0/KVvP1Y9606	rogid:90JtkJet79Lm8v1cD6ggYERSrEM9606	rigid:fFuISsOO/ycLrm7idQkpxrKwwC4	false	binding-associated region:263-345	binding-associated region:86-122	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02749	uniprotkb:P01130	intact:EBI-2114682|uniprotkb:Q9UCN7|uniprotkb:B2R9M3|ensembl:ENSP00000205948	intact:EBI-988319|uniprotkb:Q53ZD9|ensembl:ENSP00000454071|uniprotkb:C0JYY8|uniprotkb:Q9UDH7|uniprotkb:B4DJZ8|uniprotkb:B4DR00|uniprotkb:B4DTQ3|uniprotkb:H0YLU8|uniprotkb:Q59FQ1|uniprotkb:B4DII3|uniprotkb:H0YNT7	psi-mi:apoh_human(display_long)|uniprotkb:APOH(gene name)|psi-mi:APOH(display_short)|uniprotkb:B2G1(gene name synonym)|uniprotkb:Beta-2-glycoprotein I(gene name synonym)|uniprotkb:Apolipoprotein H(gene name synonym)|uniprotkb:Activated protein C-binding protein(gene name synonym)|uniprotkb:APC inhibitor(gene name synonym)|uniprotkb:Anticardiolipin cofactor(gene name synonym)	psi-mi:ldlr_human(display_long)|uniprotkb:LDLR(gene name)|psi-mi:LDLR(display_short)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Lee et al. (2010)	pubmed:20223219|doi:10.1016/j.str.2009.12.013|imex:IM-15912	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15842278|imex:IM-15912-5|dip:DIP-186298E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000033.2|dip:DIP-46878N|ensembl:ENSG00000091583(gene)|ensembl:ENST00000205948(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007597"(blood coagulation, intrinsic pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0031639"(plasminogen activation)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042627"(chylomicron)|go:"GO:0042802"(identical protein binding)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051917"(regulation of fibrinolysis)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0060230"(lipoprotein lipase activator activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR015104(Beta-2-glycoprotein-1 fifth domain)|interpro:IPR035976|mint:P02749|rcsb pdb:1C1Z|rcsb pdb:1G4F|rcsb pdb:1G4G|rcsb pdb:1QUB|rcsb pdb:2KRI|rcsb pdb:3OP8|rcsb pdb:4JHS|rcsb pdb:6V06|rcsb pdb:6V08|rcsb pdb:6V09|reactome:R-HSA-114608	refseq:NP_000518.1|ensembl:ENSG00000130164(gene)|ensembl:ENST00000558518(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002020"(protease binding)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007616"(long-term memory)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010899"(regulation of phosphatidylcholine catabolic process)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070508"(cholesterol import)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097443"(sorting endosome)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990666"(PCSK9-LDLR complex)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|go:"GO:0030169"(low-density lipoprotein particle binding)|interpro:IPR036055|rcsb pdb:1AJJ|rcsb pdb:1D2J|rcsb pdb:1F5Y|rcsb pdb:1F8Z|rcsb pdb:1HJ7|rcsb pdb:1HZ8|rcsb pdb:1I0U|rcsb pdb:1IJQ|rcsb pdb:1LDL|mint:P01130|rcsb pdb:1LDR|rcsb pdb:1LRX|rcsb pdb:1N7D|rcsb pdb:1XFE|rcsb pdb:2FCW|rcsb pdb:2KRI|rcsb pdb:2LGP|rcsb pdb:2M7P|rcsb pdb:2MG9|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SO6|rcsb pdb:4NE9|rcsb pdb:5OY9|rcsb pdb:5OYL|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8964026|reactome:R-HSA-8964038|reactome:R-HSA-975634|rcsb pdb:2W2M|refseq:NP_001182732.1|refseq:NP_001182728.1|refseq:NP_001182729.1|refseq:NP_001182727.1|dip:DIP-29695N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:IcohvxbMLnnzWe0jmOC0/KVvP1Y9606	rogid:90JtkJet79Lm8v1cD6ggYERSrEM9606	rigid:fFuISsOO/ycLrm7idQkpxrKwwC4	false	binding-associated region:263-345	binding-associated region:126-165|fluorescent dye label:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)