#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q7KTX7 uniprotkb:Q7YU24 intact:EBI-131530|uniprotkb:Q86CZ3|ensemblmetazoa:FBpp0077974|ensemblmetazoa:FBpp0077975|uniprotkb:Q86LE7|uniprotkb:Q95TI4 intact:EBI-83262|uniprotkb:Q0KHV7|uniprotkb:Q86DQ3|uniprotkb:Q8T3J4|uniprotkb:Q9W3Z9|ensemblmetazoa:FBpp0089221|ensemblmetazoa:FBpp0089222 psi-mi:prkn_drome(display_long)|uniprotkb:park(gene name)|psi-mi:park(display_short)|uniprotkb:parkin(gene name synonym)|uniprotkb:CG10523(orf name) psi-mi:marf_drome(display_long)|uniprotkb:Marf(gene name)|psi-mi:Marf(display_short)|uniprotkb:dmfn(gene name synonym)|uniprotkb:Mitochondrial assembly regulatory factor(gene name synonym)|uniprotkb:Mitofusin(gene name synonym)|uniprotkb:CG3869(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ziviani et al. (2010) pubmed:20194754|doi:10.1073/pnas.0913485107|imex:IM-15228 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15839771|imex:IM-15228-1|dip:DIP-185719E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_730600.1|refseq:NP_730601.1|flybase:FBgn0041100|ensemblmetazoa:FBgn0041100(gene)|ensemblmetazoa:FBtr0078318(transcript)|ensemblmetazoa:FBtr0078319(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008345"(larval locomotory behavior)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030382"(sperm mitochondrion organization)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048078"(positive regulation of compound eye pigmentation)|go:"GO:0048477"(oogenesis)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904061"(positive regulation of locomotor rhythm)|go:"GO:1904457"(positive regulation of neuronal action potential)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|rcsb pdb:2LWR|rcsb pdb:2M48|reactome:R-DME-5205685|reactome:R-DME-5689877|reactome:R-DME-9646399|reactome:R-DME-983168|dip:DIP-58616N refseq:NP_572320.2|ensemblmetazoa:FBgn0029870(gene)|ensemblmetazoa:FBtr0070909(transcript)|ensemblmetazoa:FBtr0070910(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006697"(ecdysone biosynthetic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0031306"(intrinsic component of mitochondrial outer membrane)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006884(Fzo-like conserved region)|interpro:IPR022812|interpro:IPR027088|interpro:IPR027094|interpro:IPR027417|interpro:IPR030381|reactome:R-DME-5205685|reactome:R-DME-9013419|reactome:R-DME-983231|refseq:NP_996357.1|refseq:NP_996358.2|flybase:FBgn0029870|dip:DIP-58614N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/10 rogid:jJZradBxxVEvnfOS83ZuWvDQhwY7227 rogid:VhP30Uag4png4aprsB1/bP/uQTY7227 rigid:vDzLgmJgEubhNIKM9OjPrjsiOX8 false green fluorescent protein tag:c-c flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P68198 uniprotkb:Q7YU24 intact:EBI-86340|uniprotkb:Q0E8I1|uniprotkb:Q9VKW6|uniprotkb:Q9VQX7|uniprotkb:Q9VZL4|dip:DIP-32843N intact:EBI-83262|uniprotkb:Q0KHV7|uniprotkb:Q86DQ3|uniprotkb:Q8T3J4|uniprotkb:Q9W3Z9|ensemblmetazoa:FBpp0089221|ensemblmetazoa:FBpp0089222 psi-mi:ubiq_drome(display_long)|uniprotkb:RpL40(gene name)|psi-mi:RpL40(display_short)|uniprotkb:CG2960(orf name)|uniprotkb:RpS27A(gene name)|psi-mi:RpS27A(display_short)|uniprotkb:UBI-F80(gene name synonym)|uniprotkb:Ubi-f(gene name synonym)|uniprotkb:CG5271(orf name)|uniprotkb:Ubi-p63E(gene name)|psi-mi:Ubi-p63E(display_short)|uniprotkb:Ubi-m(gene name synonym)|uniprotkb:CG11624(orf name) psi-mi:marf_drome(display_long)|uniprotkb:Marf(gene name)|psi-mi:Marf(display_short)|uniprotkb:dmfn(gene name synonym)|uniprotkb:Mitochondrial assembly regulatory factor(gene name synonym)|uniprotkb:Mitofusin(gene name synonym)|uniprotkb:CG3869(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ziviani et al. (2010) pubmed:20194754|doi:10.1073/pnas.0913485107|imex:IM-15228 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15839792|imex:IM-15228-2|dip:DIP-185717E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000626(Ubiquitin)|flybase:FBgn0003941(RpL40)|flybase:FBgn0003943(Ubi-p63E)|go:"GO:0006911"(phagocytosis, engulfment)|refseq:NP_476776.1|refseq:NP_476778.1|refseq:NP_728908.1|go:"GO:0005515"(protein binding)|flybase:FBgn0003942(RpS27A)|go:"GO:0030528"(obsolete transcription regulator activity)|go:"GO:0045941"|go:"GO:0016567"(protein ubiquitination)|go:"GO:0009408"(response to heat)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:FBgn0003943|ensembl:FBgn0003941|ensembl:FBgn0003942|refseq:NP_523909.2|refseq:NP_995994.1|ensembl:FBgn0086558 refseq:NP_572320.2|ensemblmetazoa:FBgn0029870(gene)|ensemblmetazoa:FBtr0070909(transcript)|ensemblmetazoa:FBtr0070910(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006697"(ecdysone biosynthetic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0031306"(intrinsic component of mitochondrial outer membrane)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006884(Fzo-like conserved region)|interpro:IPR022812|interpro:IPR027088|interpro:IPR027094|interpro:IPR027417|interpro:IPR030381|reactome:R-DME-5205685|reactome:R-DME-9013419|reactome:R-DME-983231|refseq:NP_996357.1|refseq:NP_996358.2|flybase:FBgn0029870|dip:DIP-58614N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/15 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM7227 rogid:VhP30Uag4png4aprsB1/bP/uQTY7227 rigid:8gvK0+ETiHi4cKIhlHfjdJpyPmg false ha tag:0-0 flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q95U20 uniprotkb:P68198 intact:EBI-161668|ensemblmetazoa:FBpp0086699 intact:EBI-86340|uniprotkb:Q0E8I1|uniprotkb:Q9VKW6|uniprotkb:Q9VQX7|uniprotkb:Q9VZL4|dip:DIP-32843N psi-mi:q95u20_drome(display_long)|uniprotkb:Opa1(gene name)|psi-mi:Opa1(display_short)|uniprotkb:opa1-like(gene name synonym)|uniprotkb:Dmel_CG8479(orf name)|uniprotkb:Dynamin-like 120 kDa protein, mitochondrial(gene name synonym)|uniprotkb:CG8479(orf name)|uniprotkb:Dmel\CG8479(gene name synonym)|uniprotkb:OPA1(gene name synonym)|uniprotkb:OPA1-like(gene name synonym)|uniprotkb:Opa1-like(gene name synonym)|uniprotkb:dOPA1(gene name synonym)|uniprotkb:dOpa1(gene name synonym)|uniprotkb:"l(2)s3475"(gene name synonym)|uniprotkb:opa1(gene name synonym) psi-mi:ubiq_drome(display_long)|uniprotkb:RpL40(gene name)|psi-mi:RpL40(display_short)|uniprotkb:CG2960(orf name)|uniprotkb:RpS27A(gene name)|psi-mi:RpS27A(display_short)|uniprotkb:UBI-F80(gene name synonym)|uniprotkb:Ubi-f(gene name synonym)|uniprotkb:CG5271(orf name)|uniprotkb:Ubi-p63E(gene name)|psi-mi:Ubi-p63E(display_short)|uniprotkb:Ubi-m(gene name synonym)|uniprotkb:CG11624(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ziviani et al. (2010) pubmed:20194754|doi:10.1073/pnas.0913485107|imex:IM-15228 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15839813|imex:IM-15228-3|dip:DIP-185718E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_610941.1|flybase:FBgn0261276|ensemblmetazoa:FBgn0261276(gene)|ensemblmetazoa:FBtr0087573(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008289"(lipid binding)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0061025"(membrane fusion)|go:"GO:0070584"(mitochondrion morphogenesis)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|dip:DIP-58615N interpro:IPR000626(Ubiquitin)|flybase:FBgn0003941(RpL40)|flybase:FBgn0003943(Ubi-p63E)|go:"GO:0006911"(phagocytosis, engulfment)|refseq:NP_476776.1|refseq:NP_476778.1|refseq:NP_728908.1|go:"GO:0005515"(protein binding)|flybase:FBgn0003942(RpS27A)|go:"GO:0030528"(obsolete transcription regulator activity)|go:"GO:0045941"|go:"GO:0016567"(protein ubiquitination)|go:"GO:0009408"(response to heat)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:FBgn0003943|ensembl:FBgn0003941|ensembl:FBgn0003942|refseq:NP_523909.2|refseq:NP_995994.1|ensembl:FBgn0086558 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/15 rogid:6iJ7oVR8n8cUzbGODnCantor98U7227 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM7227 rigid:sSUrE7ELC/gkcPF9XP2lIVRJc1g false flag tag:c-c ha tag:0-0 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)