#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q13950 uniprotkb:Q04724 intact:EBI-976402|intact:EBI-28971669|ensembl:ENSP00000360493|ensembl:ENSP00000495497|uniprotkb:O14614|uniprotkb:O14615|uniprotkb:O95181 intact:EBI-711424|uniprotkb:Q5T3G4|uniprotkb:Q969V9|ensembl:ENSP00000365682|uniprotkb:A8K495 psi-mi:runx2_human(display_long)|uniprotkb:Oncogene AML-3(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha A subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha A subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha A subunit(gene name synonym)|uniprotkb:Osteoblast-specific transcription factor 2(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-1(gene name synonym)|uniprotkb:Acute myeloid leukemia 3 protein(gene name synonym)|uniprotkb:RUNX2(gene name)|psi-mi:RUNX2(display_short)|uniprotkb:AML3(gene name synonym)|uniprotkb:CBFA1(gene name synonym)|uniprotkb:OSF2(gene name synonym)|uniprotkb:PEBP2A(gene name synonym) psi-mi:tle1_human(display_long)|uniprotkb:TLE1(gene name)|psi-mi:TLE1(display_short)|uniprotkb:Enhancer of split groucho-like protein 1(gene name synonym)|uniprotkb:"E(Sp1) homolog"(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ali et al. (2010) pubmed:20160071|doi:10.1073/pnas.1000620107|imex:IM-17426 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15836461|imex:IM-17426-1|dip:DIP-188325E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000359524|ensembl:ENSP00000352514|ensembl:ENST00000371432|ensembl:ENSP00000360486|ensembl:ENST00000371436|ensembl:ENSP00000360491|ensembl:ENSP00000360493|ensembl:ENSP00000495497|ensembl:ENSG00000124813(gene)|ensembl:ENST00000371438(transcript)|ensembl:ENST00000647337(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|interpro:IPR027384|mint:Q13950|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043425"(bHLH transcription factor binding)|rcsb pdb:6VG8|rcsb pdb:6VGD|rcsb pdb:6VGE|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|rcsb pdb:6VGG|reactome:R-HSA-2032785|reactome:R-HSA-8878166|reactome:R-HSA-8939246|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326|reactome:R-HSA-8941332|reactome:R-HSA-8941333|refseq:NP_001015051.3|refseq:NP_001019801.3|dip:DIP-36707N mint:Q04724|rcsb pdb:1GXR|rcsb pdb:2CE8|rcsb pdb:2CE9|rcsb pdb:4OM2|rcsb pdb:4OM3|rcsb pdb:5MWJ|reactome:R-HSA-201722|reactome:R-HSA-2122947|reactome:R-HSA-3769402|reactome:R-HSA-4641265|ensembl:ENSG00000196781(gene)|ensembl:ENST00000376499(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR001680(WD40 repeat)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|refseq:NP_005068.2|refseq:NP_001290032.1|refseq:NP_001290033.1|dip:DIP-36665N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:aUhn8jpJsl5oS4kMBgUYdpncy6Y9606 rogid:mOWun+rOiFbfy4AZ1pQ+K3GRriU9606 rigid:xoz3EGLZgOYc8IlzZRQclrx5NwY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13950 uniprotkb:P17480 intact:EBI-976402|intact:EBI-28971669|ensembl:ENSP00000360493|ensembl:ENSP00000495497|uniprotkb:O14614|uniprotkb:O14615|uniprotkb:O95181 intact:EBI-396235|uniprotkb:A8K6R8|ensembl:ENSP00000302640|ensembl:ENSP00000390669|ensembl:ENSP00000435708 psi-mi:runx2_human(display_long)|uniprotkb:Oncogene AML-3(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha A subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha A subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha A subunit(gene name synonym)|uniprotkb:Osteoblast-specific transcription factor 2(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-1(gene name synonym)|uniprotkb:Acute myeloid leukemia 3 protein(gene name synonym)|uniprotkb:RUNX2(gene name)|psi-mi:RUNX2(display_short)|uniprotkb:AML3(gene name synonym)|uniprotkb:CBFA1(gene name synonym)|uniprotkb:OSF2(gene name synonym)|uniprotkb:PEBP2A(gene name synonym) psi-mi:ubf1_human(display_long)|uniprotkb:UBTF(gene name)|psi-mi:UBTF(display_short)|uniprotkb:UBF(gene name synonym)|uniprotkb:UBF1(gene name synonym)|uniprotkb:Upstream-binding factor 1(gene name synonym)|uniprotkb:Autoantigen NOR-90(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ali et al. (2010) pubmed:20160071|doi:10.1073/pnas.1000620107|imex:IM-17426 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15836461|imex:IM-17426-1|dip:DIP-188325E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000359524|ensembl:ENSP00000352514|ensembl:ENST00000371432|ensembl:ENSP00000360486|ensembl:ENST00000371436|ensembl:ENSP00000360491|ensembl:ENSP00000360493|ensembl:ENSP00000495497|ensembl:ENSG00000124813(gene)|ensembl:ENST00000371438(transcript)|ensembl:ENST00000647337(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|interpro:IPR027384|mint:Q13950|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043425"(bHLH transcription factor binding)|rcsb pdb:6VG8|rcsb pdb:6VGD|rcsb pdb:6VGE|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|rcsb pdb:6VGG|reactome:R-HSA-2032785|reactome:R-HSA-8878166|reactome:R-HSA-8939246|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326|reactome:R-HSA-8941332|reactome:R-HSA-8941333|refseq:NP_001015051.3|refseq:NP_001019801.3|dip:DIP-36707N refseq:NP_001070151.1|refseq:NP_001070152.1|refseq:NP_055048.1|refseq:XP_006722122.1|refseq:XP_006722123.1|refseq:XP_006722124.1|refseq:XP_016880492.1|refseq:XP_016880493.1|dip:DIP-640N|ensembl:ENSG00000108312(gene)|ensembl:ENST00000302904(transcript)|ensembl:ENST00000436088(transcript)|ensembl:ENST00000529383(transcript)|go:"GO:0001164"(RNA polymerase I core promoter sequence-specific DNA binding)|go:"GO:0001165"(RNA polymerase I cis-regulatory region sequence-specific DNA binding)|go:"GO:0001181"(RNA polymerase I general transcription initiation factor activity)|go:"GO:0001650"(fibrillar center)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006361"(transcription initiation from RNA polymerase I promoter)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR029215|interpro:IPR036910|mint:P17480|rcsb pdb:1K99|rcsb pdb:1L8Y|rcsb pdb:1L8Z|rcsb pdb:2HDZ|reactome:R-HSA-427413|reactome:R-HSA-73728|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:aUhn8jpJsl5oS4kMBgUYdpncy6Y9606 rogid:uHwgY0OFREKv8MdMOMpREDgUEI89606 rigid:xoz3EGLZgOYc8IlzZRQclrx5NwY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P17480 uniprotkb:Q04724 intact:EBI-396235|uniprotkb:A8K6R8|ensembl:ENSP00000302640|ensembl:ENSP00000390669|ensembl:ENSP00000435708 intact:EBI-711424|uniprotkb:Q5T3G4|uniprotkb:Q969V9|ensembl:ENSP00000365682|uniprotkb:A8K495 psi-mi:ubf1_human(display_long)|uniprotkb:UBTF(gene name)|psi-mi:UBTF(display_short)|uniprotkb:UBF(gene name synonym)|uniprotkb:UBF1(gene name synonym)|uniprotkb:Upstream-binding factor 1(gene name synonym)|uniprotkb:Autoantigen NOR-90(gene name synonym) psi-mi:tle1_human(display_long)|uniprotkb:TLE1(gene name)|psi-mi:TLE1(display_short)|uniprotkb:Enhancer of split groucho-like protein 1(gene name synonym)|uniprotkb:"E(Sp1) homolog"(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ali et al. (2010) pubmed:20160071|doi:10.1073/pnas.1000620107|imex:IM-17426 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15836479|imex:IM-17426-2|dip:DIP-188325E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001070151.1|refseq:NP_001070152.1|refseq:NP_055048.1|refseq:XP_006722122.1|refseq:XP_006722123.1|refseq:XP_006722124.1|refseq:XP_016880492.1|refseq:XP_016880493.1|dip:DIP-640N|ensembl:ENSG00000108312(gene)|ensembl:ENST00000302904(transcript)|ensembl:ENST00000436088(transcript)|ensembl:ENST00000529383(transcript)|go:"GO:0001164"(RNA polymerase I core promoter sequence-specific DNA binding)|go:"GO:0001165"(RNA polymerase I cis-regulatory region sequence-specific DNA binding)|go:"GO:0001181"(RNA polymerase I general transcription initiation factor activity)|go:"GO:0001650"(fibrillar center)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006361"(transcription initiation from RNA polymerase I promoter)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR029215|interpro:IPR036910|mint:P17480|rcsb pdb:1K99|rcsb pdb:1L8Y|rcsb pdb:1L8Z|rcsb pdb:2HDZ|reactome:R-HSA-427413|reactome:R-HSA-73728|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 mint:Q04724|rcsb pdb:1GXR|rcsb pdb:2CE8|rcsb pdb:2CE9|rcsb pdb:4OM2|rcsb pdb:4OM3|rcsb pdb:5MWJ|reactome:R-HSA-201722|reactome:R-HSA-2122947|reactome:R-HSA-3769402|reactome:R-HSA-4641265|ensembl:ENSG00000196781(gene)|ensembl:ENST00000376499(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR001680(WD40 repeat)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|refseq:NP_005068.2|refseq:NP_001290032.1|refseq:NP_001290033.1|dip:DIP-36665N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:uHwgY0OFREKv8MdMOMpREDgUEI89606 rogid:mOWun+rOiFbfy4AZ1pQ+K3GRriU9606 rigid:xoz3EGLZgOYc8IlzZRQclrx5NwY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P17480 uniprotkb:Q13950 intact:EBI-396235|uniprotkb:A8K6R8|ensembl:ENSP00000302640|ensembl:ENSP00000390669|ensembl:ENSP00000435708 intact:EBI-976402|intact:EBI-28971669|ensembl:ENSP00000360493|ensembl:ENSP00000495497|uniprotkb:O14614|uniprotkb:O14615|uniprotkb:O95181 psi-mi:ubf1_human(display_long)|uniprotkb:UBTF(gene name)|psi-mi:UBTF(display_short)|uniprotkb:UBF(gene name synonym)|uniprotkb:UBF1(gene name synonym)|uniprotkb:Upstream-binding factor 1(gene name synonym)|uniprotkb:Autoantigen NOR-90(gene name synonym) psi-mi:runx2_human(display_long)|uniprotkb:Oncogene AML-3(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha A subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha A subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha A subunit(gene name synonym)|uniprotkb:Osteoblast-specific transcription factor 2(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-1(gene name synonym)|uniprotkb:Acute myeloid leukemia 3 protein(gene name synonym)|uniprotkb:RUNX2(gene name)|psi-mi:RUNX2(display_short)|uniprotkb:AML3(gene name synonym)|uniprotkb:CBFA1(gene name synonym)|uniprotkb:OSF2(gene name synonym)|uniprotkb:PEBP2A(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ali et al. (2010) pubmed:20160071|doi:10.1073/pnas.1000620107|imex:IM-17426 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15836479|imex:IM-17426-2|dip:DIP-188325E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001070151.1|refseq:NP_001070152.1|refseq:NP_055048.1|refseq:XP_006722122.1|refseq:XP_006722123.1|refseq:XP_006722124.1|refseq:XP_016880492.1|refseq:XP_016880493.1|dip:DIP-640N|ensembl:ENSG00000108312(gene)|ensembl:ENST00000302904(transcript)|ensembl:ENST00000436088(transcript)|ensembl:ENST00000529383(transcript)|go:"GO:0001164"(RNA polymerase I core promoter sequence-specific DNA binding)|go:"GO:0001165"(RNA polymerase I cis-regulatory region sequence-specific DNA binding)|go:"GO:0001181"(RNA polymerase I general transcription initiation factor activity)|go:"GO:0001650"(fibrillar center)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006361"(transcription initiation from RNA polymerase I promoter)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR029215|interpro:IPR036910|mint:P17480|rcsb pdb:1K99|rcsb pdb:1L8Y|rcsb pdb:1L8Z|rcsb pdb:2HDZ|reactome:R-HSA-427413|reactome:R-HSA-73728|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 ensembl:ENST00000359524|ensembl:ENSP00000352514|ensembl:ENST00000371432|ensembl:ENSP00000360486|ensembl:ENST00000371436|ensembl:ENSP00000360491|ensembl:ENSP00000360493|ensembl:ENSP00000495497|ensembl:ENSG00000124813(gene)|ensembl:ENST00000371438(transcript)|ensembl:ENST00000647337(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|interpro:IPR027384|mint:Q13950|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043425"(bHLH transcription factor binding)|rcsb pdb:6VG8|rcsb pdb:6VGD|rcsb pdb:6VGE|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|rcsb pdb:6VGG|reactome:R-HSA-2032785|reactome:R-HSA-8878166|reactome:R-HSA-8939246|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326|reactome:R-HSA-8941332|reactome:R-HSA-8941333|refseq:NP_001015051.3|refseq:NP_001019801.3|dip:DIP-36707N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:uHwgY0OFREKv8MdMOMpREDgUEI89606 rogid:aUhn8jpJsl5oS4kMBgUYdpncy6Y9606 rigid:xoz3EGLZgOYc8IlzZRQclrx5NwY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)