#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q495M9	uniprotkb:Q9Y6N9	intact:EBI-8601749|ensembl:ENSP00000480279|uniprotkb:Q8N251|intact:MINT-257481	intact:EBI-954308|ensembl:ENSP00000317018|uniprotkb:Q96B29|uniprotkb:Q9UM04|uniprotkb:Q9UM17|uniprotkb:Q9UPC3|uniprotkb:A8K423|uniprotkb:Q7RTU8	psi-mi:ush1g_human(display_long)|uniprotkb:USH1G(gene name)|psi-mi:USH1G(display_short)|uniprotkb:SANS(gene name synonym)|uniprotkb:Scaffold protein containing ankyrin repeats and SAM domain(gene name synonym)	psi-mi:ush1c_human(display_long)|uniprotkb:Usher syndrome type-1C protein(gene name synonym)|uniprotkb:Autoimmune enteropathy-related antigen AIE-75(gene name synonym)|uniprotkb:Antigen NY-CO-38/NY-CO-37(gene name synonym)|uniprotkb:Protein PDZ-73(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-3(gene name synonym)|uniprotkb:USH1C(gene name)|psi-mi:USH1C(display_short)|uniprotkb:AIE75(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Yan et al. (2010)	pubmed:20142502|doi:10.1073/pnas.0911385107|imex:IM-15222	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15834576|imex:IM-15222-1|dip:DIP-70803E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|interpro:IPR037602|rcsb pdb:2L7T|rcsb pdb:3K1R|ensembl:ENSG00000182040(gene)|ensembl:ENST00000614341(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030507"(spectrin binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050957"(equilibrioception)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|interpro:IPR001660(Sterile alpha motif SAM)|rcsb pdb:3PVL|reactome:R-HSA-9662361|reactome:R-HSA-9662360|refseq:NP_775748.2|refseq:NP_001269418.1|dip:DIP-41617N	go:"GO:0002142"(stereocilia ankle link complex)|go:"GO:0030046"(parallel actin filament bundle assembly)|go:"GO:0030507"(spectrin binding)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0034622"|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050957"(equilibrioception)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:1904106"(protein localization to microvillus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:1904970"(brush border assembly)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030237|interpro:IPR036034|rcsb pdb:1X5N|rcsb pdb:2KBQ|rcsb pdb:2KBR|rcsb pdb:2KBS|rcsb pdb:2LSR|rcsb pdb:3K1R|rcsb pdb:5F3X|rcsb pdb:5MV8|rcsb pdb:5MV9|rcsb pdb:5XBF|reactome:R-HSA-9662360|reactome:R-HSA-9662361|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENSG00000006611(gene)|ensembl:ENST00000318024(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|refseq:NP_005700.2|refseq:NP_001284693.1|refseq:NP_710142.1|dip:DIP-41473N	psi-mi:"MI:0465"(dip)	comment:mint|function:Unknown. Required for normal hearing. May have a role in the development and maintenance of the stereocilia bundles. Might function as an anchoring/scaffolding protein in hair cells. Could be involved in the functional network formed by USH1C, CDH23 and MYO7A that is required for cohesion of the growing hair bundle|function:"Defects in USH1G are the cause of Usher syndrome type 1G (USH1G) [MIM:606943]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:0gxWTLxy7uDKQtmmwaHpjhnR9XM9606	rogid:FZD03Nq9dvV88xyKOBIgshO3Fvg9606	rigid:IgazcWfpx2obpaYnxojpT0JamXs	false	binding-associated region:384-461	binding-associated region:1-192	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q495M9	uniprotkb:Q9Y6N9	intact:EBI-8601749|ensembl:ENSP00000480279|uniprotkb:Q8N251|intact:MINT-257481	intact:EBI-954308|ensembl:ENSP00000317018|uniprotkb:Q96B29|uniprotkb:Q9UM04|uniprotkb:Q9UM17|uniprotkb:Q9UPC3|uniprotkb:A8K423|uniprotkb:Q7RTU8	psi-mi:ush1g_human(display_long)|uniprotkb:USH1G(gene name)|psi-mi:USH1G(display_short)|uniprotkb:SANS(gene name synonym)|uniprotkb:Scaffold protein containing ankyrin repeats and SAM domain(gene name synonym)	psi-mi:ush1c_human(display_long)|uniprotkb:Usher syndrome type-1C protein(gene name synonym)|uniprotkb:Autoimmune enteropathy-related antigen AIE-75(gene name synonym)|uniprotkb:Antigen NY-CO-38/NY-CO-37(gene name synonym)|uniprotkb:Protein PDZ-73(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-3(gene name synonym)|uniprotkb:USH1C(gene name)|psi-mi:USH1C(display_short)|uniprotkb:AIE75(gene name synonym)	psi-mi:"MI:0096"(pull down)	Yan et al. (2010)	pubmed:20142502|doi:10.1073/pnas.0911385107|imex:IM-15222	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15834597|imex:IM-15222-2|dip:DIP-70803E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|interpro:IPR037602|rcsb pdb:2L7T|rcsb pdb:3K1R|ensembl:ENSG00000182040(gene)|ensembl:ENST00000614341(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030507"(spectrin binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050957"(equilibrioception)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|interpro:IPR001660(Sterile alpha motif SAM)|rcsb pdb:3PVL|reactome:R-HSA-9662361|reactome:R-HSA-9662360|refseq:NP_775748.2|refseq:NP_001269418.1|dip:DIP-41617N	go:"GO:0002142"(stereocilia ankle link complex)|go:"GO:0030046"(parallel actin filament bundle assembly)|go:"GO:0030507"(spectrin binding)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0034622"|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050957"(equilibrioception)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:1904106"(protein localization to microvillus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:1904970"(brush border assembly)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030237|interpro:IPR036034|rcsb pdb:1X5N|rcsb pdb:2KBQ|rcsb pdb:2KBR|rcsb pdb:2KBS|rcsb pdb:2LSR|rcsb pdb:3K1R|rcsb pdb:5F3X|rcsb pdb:5MV8|rcsb pdb:5MV9|rcsb pdb:5XBF|reactome:R-HSA-9662360|reactome:R-HSA-9662361|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENSG00000006611(gene)|ensembl:ENST00000318024(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|refseq:NP_005700.2|refseq:NP_001284693.1|refseq:NP_710142.1|dip:DIP-41473N	psi-mi:"MI:0465"(dip)	comment:mint|function:Unknown. Required for normal hearing. May have a role in the development and maintenance of the stereocilia bundles. Might function as an anchoring/scaffolding protein in hair cells. Could be involved in the functional network formed by USH1C, CDH23 and MYO7A that is required for cohesion of the growing hair bundle|function:"Defects in USH1G are the cause of Usher syndrome type 1G (USH1G) [MIM:606943]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:0gxWTLxy7uDKQtmmwaHpjhnR9XM9606	rogid:FZD03Nq9dvV88xyKOBIgshO3Fvg9606	rigid:IgazcWfpx2obpaYnxojpT0JamXs	false	sufficient binding region:384-458	binding-associated region:1-192|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q495M9	uniprotkb:Q495M9	intact:EBI-8601749|ensembl:ENSP00000480279|uniprotkb:Q8N251|intact:MINT-257481	intact:EBI-8601749|ensembl:ENSP00000480279|uniprotkb:Q8N251|intact:MINT-257481	psi-mi:ush1g_human(display_long)|uniprotkb:USH1G(gene name)|psi-mi:USH1G(display_short)|uniprotkb:SANS(gene name synonym)|uniprotkb:Scaffold protein containing ankyrin repeats and SAM domain(gene name synonym)	psi-mi:ush1g_human(display_long)|uniprotkb:USH1G(gene name)|psi-mi:USH1G(display_short)|uniprotkb:SANS(gene name synonym)|uniprotkb:Scaffold protein containing ankyrin repeats and SAM domain(gene name synonym)	psi-mi:"MI:0028"(cosedimentation in solution)	Yan et al. (2010)	pubmed:20142502|doi:10.1073/pnas.0911385107|imex:IM-15222	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15834620|imex:IM-15222-3|dip:DIP-185703E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|interpro:IPR037602|rcsb pdb:2L7T|rcsb pdb:3K1R|ensembl:ENSG00000182040(gene)|ensembl:ENST00000614341(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030507"(spectrin binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050957"(equilibrioception)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|interpro:IPR001660(Sterile alpha motif SAM)|rcsb pdb:3PVL|reactome:R-HSA-9662361|reactome:R-HSA-9662360|refseq:NP_775748.2|refseq:NP_001269418.1|dip:DIP-41617N	interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|interpro:IPR037602|rcsb pdb:2L7T|rcsb pdb:3K1R|ensembl:ENSG00000182040(gene)|ensembl:ENST00000614341(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030507"(spectrin binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050957"(equilibrioception)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|interpro:IPR001660(Sterile alpha motif SAM)|rcsb pdb:3PVL|reactome:R-HSA-9662361|reactome:R-HSA-9662360|refseq:NP_775748.2|refseq:NP_001269418.1|dip:DIP-41617N	psi-mi:"MI:0465"(dip)	comment:mint|function:Unknown. Required for normal hearing. May have a role in the development and maintenance of the stereocilia bundles. Might function as an anchoring/scaffolding protein in hair cells. Could be involved in the functional network formed by USH1C, CDH23 and MYO7A that is required for cohesion of the growing hair bundle|function:"Defects in USH1G are the cause of Usher syndrome type 1G (USH1G) [MIM:606943]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness"	comment:mint|function:Unknown. Required for normal hearing. May have a role in the development and maintenance of the stereocilia bundles. Might function as an anchoring/scaffolding protein in hair cells. Could be involved in the functional network formed by USH1C, CDH23 and MYO7A that is required for cohesion of the growing hair bundle|function:"Defects in USH1G are the cause of Usher syndrome type 1G (USH1G) [MIM:606943]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/06	2017/08/10	rogid:0gxWTLxy7uDKQtmmwaHpjhnR9XM9606	rogid:0gxWTLxy7uDKQtmmwaHpjhnR9XM9606	rigid:+vfezUcs+1ZDEtXeh0HJnpNFo3M	false	binding-associated region:384-461|mutation disrupting interaction:437-437	binding-associated region:384-461|mutation disrupting interaction:437-437	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q495M9	uniprotkb:Q495M9	intact:EBI-8601749|ensembl:ENSP00000480279|uniprotkb:Q8N251|intact:MINT-257481	intact:EBI-8601749|ensembl:ENSP00000480279|uniprotkb:Q8N251|intact:MINT-257481	psi-mi:ush1g_human(display_long)|uniprotkb:USH1G(gene name)|psi-mi:USH1G(display_short)|uniprotkb:SANS(gene name synonym)|uniprotkb:Scaffold protein containing ankyrin repeats and SAM domain(gene name synonym)	psi-mi:ush1g_human(display_long)|uniprotkb:USH1G(gene name)|psi-mi:USH1G(display_short)|uniprotkb:SANS(gene name synonym)|uniprotkb:Scaffold protein containing ankyrin repeats and SAM domain(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Yan et al. (2010)	pubmed:20142502|doi:10.1073/pnas.0911385107|imex:IM-15222	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15834641|imex:IM-15222-4|dip:DIP-185703E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|interpro:IPR037602|rcsb pdb:2L7T|rcsb pdb:3K1R|ensembl:ENSG00000182040(gene)|ensembl:ENST00000614341(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030507"(spectrin binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050957"(equilibrioception)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|interpro:IPR001660(Sterile alpha motif SAM)|rcsb pdb:3PVL|reactome:R-HSA-9662361|reactome:R-HSA-9662360|refseq:NP_775748.2|refseq:NP_001269418.1|dip:DIP-41617N	interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|interpro:IPR037602|rcsb pdb:2L7T|rcsb pdb:3K1R|ensembl:ENSG00000182040(gene)|ensembl:ENST00000614341(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030507"(spectrin binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050957"(equilibrioception)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|interpro:IPR001660(Sterile alpha motif SAM)|rcsb pdb:3PVL|reactome:R-HSA-9662361|reactome:R-HSA-9662360|refseq:NP_775748.2|refseq:NP_001269418.1|dip:DIP-41617N	psi-mi:"MI:0465"(dip)	comment:mint|function:Unknown. Required for normal hearing. May have a role in the development and maintenance of the stereocilia bundles. Might function as an anchoring/scaffolding protein in hair cells. Could be involved in the functional network formed by USH1C, CDH23 and MYO7A that is required for cohesion of the growing hair bundle|function:"Defects in USH1G are the cause of Usher syndrome type 1G (USH1G) [MIM:606943]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness"	comment:mint|function:Unknown. Required for normal hearing. May have a role in the development and maintenance of the stereocilia bundles. Might function as an anchoring/scaffolding protein in hair cells. Could be involved in the functional network formed by USH1C, CDH23 and MYO7A that is required for cohesion of the growing hair bundle|function:"Defects in USH1G are the cause of Usher syndrome type 1G (USH1G) [MIM:606943]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/06	2017/08/10	rogid:0gxWTLxy7uDKQtmmwaHpjhnR9XM9606	rogid:0gxWTLxy7uDKQtmmwaHpjhnR9XM9606	rigid:+vfezUcs+1ZDEtXeh0HJnpNFo3M	false	binding-associated region:384-461|mutation disrupting interaction:437-437	binding-associated region:384-461|mutation disrupting interaction:437-437	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q495M9	uniprotkb:Q9Y6N9	intact:EBI-8601749|ensembl:ENSP00000480279|uniprotkb:Q8N251|intact:MINT-257481	intact:EBI-954308|ensembl:ENSP00000317018|uniprotkb:Q96B29|uniprotkb:Q9UM04|uniprotkb:Q9UM17|uniprotkb:Q9UPC3|uniprotkb:A8K423|uniprotkb:Q7RTU8	psi-mi:ush1g_human(display_long)|uniprotkb:USH1G(gene name)|psi-mi:USH1G(display_short)|uniprotkb:SANS(gene name synonym)|uniprotkb:Scaffold protein containing ankyrin repeats and SAM domain(gene name synonym)	psi-mi:ush1c_human(display_long)|uniprotkb:Usher syndrome type-1C protein(gene name synonym)|uniprotkb:Autoimmune enteropathy-related antigen AIE-75(gene name synonym)|uniprotkb:Antigen NY-CO-38/NY-CO-37(gene name synonym)|uniprotkb:Protein PDZ-73(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-3(gene name synonym)|uniprotkb:USH1C(gene name)|psi-mi:USH1C(display_short)|uniprotkb:AIE75(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Yan et al. (2010)	pubmed:20142502|doi:10.1073/pnas.0911385107|imex:IM-15222	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15834662|imex:IM-15222-5|dip:DIP-70803E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|interpro:IPR037602|rcsb pdb:2L7T|rcsb pdb:3K1R|ensembl:ENSG00000182040(gene)|ensembl:ENST00000614341(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030507"(spectrin binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050957"(equilibrioception)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|interpro:IPR001660(Sterile alpha motif SAM)|rcsb pdb:3PVL|reactome:R-HSA-9662361|reactome:R-HSA-9662360|refseq:NP_775748.2|refseq:NP_001269418.1|dip:DIP-41617N	go:"GO:0002142"(stereocilia ankle link complex)|go:"GO:0030046"(parallel actin filament bundle assembly)|go:"GO:0030507"(spectrin binding)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0034622"|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050957"(equilibrioception)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:1904106"(protein localization to microvillus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:1904970"(brush border assembly)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030237|interpro:IPR036034|rcsb pdb:1X5N|rcsb pdb:2KBQ|rcsb pdb:2KBR|rcsb pdb:2KBS|rcsb pdb:2LSR|rcsb pdb:3K1R|rcsb pdb:5F3X|rcsb pdb:5MV8|rcsb pdb:5MV9|rcsb pdb:5XBF|reactome:R-HSA-9662360|reactome:R-HSA-9662361|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENSG00000006611(gene)|ensembl:ENST00000318024(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|refseq:NP_005700.2|refseq:NP_001284693.1|refseq:NP_710142.1|dip:DIP-41473N	psi-mi:"MI:0465"(dip)	comment:mint|function:Unknown. Required for normal hearing. May have a role in the development and maintenance of the stereocilia bundles. Might function as an anchoring/scaffolding protein in hair cells. Could be involved in the functional network formed by USH1C, CDH23 and MYO7A that is required for cohesion of the growing hair bundle|function:"Defects in USH1G are the cause of Usher syndrome type 1G (USH1G) [MIM:606943]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:0gxWTLxy7uDKQtmmwaHpjhnR9XM9606	rogid:FZD03Nq9dvV88xyKOBIgshO3Fvg9606	rigid:IgazcWfpx2obpaYnxojpT0JamXs	false	binding-associated region:384-461|mutation decreasing interaction:458-458	binding-associated region:1-192|mutation decreasing interaction:103-103	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q495M9	uniprotkb:Q9Y6N9	intact:EBI-8601749|ensembl:ENSP00000480279|uniprotkb:Q8N251|intact:MINT-257481	intact:EBI-954308|ensembl:ENSP00000317018|uniprotkb:Q96B29|uniprotkb:Q9UM04|uniprotkb:Q9UM17|uniprotkb:Q9UPC3|uniprotkb:A8K423|uniprotkb:Q7RTU8	psi-mi:ush1g_human(display_long)|uniprotkb:USH1G(gene name)|psi-mi:USH1G(display_short)|uniprotkb:SANS(gene name synonym)|uniprotkb:Scaffold protein containing ankyrin repeats and SAM domain(gene name synonym)	psi-mi:ush1c_human(display_long)|uniprotkb:Usher syndrome type-1C protein(gene name synonym)|uniprotkb:Autoimmune enteropathy-related antigen AIE-75(gene name synonym)|uniprotkb:Antigen NY-CO-38/NY-CO-37(gene name synonym)|uniprotkb:Protein PDZ-73(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-3(gene name synonym)|uniprotkb:USH1C(gene name)|psi-mi:USH1C(display_short)|uniprotkb:AIE75(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Yan et al. (2010)	pubmed:20142502|doi:10.1073/pnas.0911385107|imex:IM-15222	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15834690|imex:IM-15222-6|dip:DIP-70803E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|interpro:IPR037602|rcsb pdb:2L7T|rcsb pdb:3K1R|ensembl:ENSG00000182040(gene)|ensembl:ENST00000614341(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030507"(spectrin binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050957"(equilibrioception)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|interpro:IPR001660(Sterile alpha motif SAM)|rcsb pdb:3PVL|reactome:R-HSA-9662361|reactome:R-HSA-9662360|refseq:NP_775748.2|refseq:NP_001269418.1|dip:DIP-41617N	go:"GO:0002142"(stereocilia ankle link complex)|go:"GO:0030046"(parallel actin filament bundle assembly)|go:"GO:0030507"(spectrin binding)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0034622"|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050957"(equilibrioception)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:1904106"(protein localization to microvillus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:1904970"(brush border assembly)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030237|interpro:IPR036034|rcsb pdb:1X5N|rcsb pdb:2KBQ|rcsb pdb:2KBR|rcsb pdb:2KBS|rcsb pdb:2LSR|rcsb pdb:3K1R|rcsb pdb:5F3X|rcsb pdb:5MV8|rcsb pdb:5MV9|rcsb pdb:5XBF|reactome:R-HSA-9662360|reactome:R-HSA-9662361|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENSG00000006611(gene)|ensembl:ENST00000318024(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|refseq:NP_005700.2|refseq:NP_001284693.1|refseq:NP_710142.1|dip:DIP-41473N	psi-mi:"MI:0465"(dip)	comment:mint|function:Unknown. Required for normal hearing. May have a role in the development and maintenance of the stereocilia bundles. Might function as an anchoring/scaffolding protein in hair cells. Could be involved in the functional network formed by USH1C, CDH23 and MYO7A that is required for cohesion of the growing hair bundle|function:"Defects in USH1G are the cause of Usher syndrome type 1G (USH1G) [MIM:606943]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:0gxWTLxy7uDKQtmmwaHpjhnR9XM9606	rogid:FZD03Nq9dvV88xyKOBIgshO3Fvg9606	rigid:IgazcWfpx2obpaYnxojpT0JamXs	false	binding-associated region:384-461	binding-associated region:1-192	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)