#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q16539-1	uniprotkb:P34080	intact:EBI-15834191|ensembl:ENSP00000229794	intact:EBI-15666323|uniprotkb:A1A5L4	psi-mi:q16539-1(display_long)|uniprotkb:MAPK14(gene name)|psi-mi:MAPK14(display_short)|uniprotkb:CSBP(gene name synonym)|uniprotkb:CSBP1(gene name synonym)|uniprotkb:CSBP2(gene name synonym)|uniprotkb:CSPB1(gene name synonym)|uniprotkb:MXI2(gene name synonym)|uniprotkb:SAPK2A(gene name synonym)|uniprotkb:Cytokine suppressive anti-inflammatory drug-binding protein(gene name synonym)|uniprotkb:MAP kinase MXI2(gene name synonym)|uniprotkb:MAX-interacting protein 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:Stress-activated protein kinase 2a(gene name synonym)	psi-mi:aqp2_rat(display_long)|uniprotkb:Aqp2(gene name)|psi-mi:Aqp2(display_short)|uniprotkb:ADH water channel(gene name synonym)|uniprotkb:Aquaporin-CD(gene name synonym)|uniprotkb:Collecting duct water channel protein(gene name synonym)|uniprotkb:WCH-CD(gene name synonym)|uniprotkb:Water channel protein for renal collecting duct(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Rinschen et al. (2010)	pubmed:20139300|doi:10.1073/pnas.0910646107|imex:IM-17418	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15834209|imex:IM-17418-1|dip:DIP-188317E	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-73946(isoform-parent)|uniprotkb:Q16539-1(isoform-parent)|ensembl:ENSG00000112062(gene)|ensembl:ENST00000229794(transcript)	go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0003779"(actin binding)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0009414"(response to water deprivation)|go:"GO:0009651"(response to salt stress)|go:"GO:0009725"(response to hormone)|go:"GO:0010226"(response to lithium ion)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015793"(glycerol transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030104"(water homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033762"(response to glucagon)|go:"GO:0042594"(response to starvation)|go:"GO:0042631"(cellular response to water deprivation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0098576"(lumenal side of membrane)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR034294|go:"GO:0030042"(actin filament depolymerization)|reactome:R-RNO-432040|reactome:R-RNO-432047|rgd:2142|refseq:NP_037041.2|dip:DIP-46223N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:oI6EOrCDVMQ6FDVBHSiYYoKZHns9606	rogid:bl4TiOnSKu5JbanszX6ncsM96+g10116	rigid:u8e4lZuT+uJsBmiGJuSB20YEZRE	false	-	binding-associated region:241-271|O-phospho-L-serine:261-261	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P45983	uniprotkb:P34080	intact:EBI-286483|uniprotkb:Q15709|uniprotkb:Q15712|uniprotkb:Q15713|uniprotkb:B7ZLV4|uniprotkb:B5BTZ5|uniprotkb:Q308M2|uniprotkb:D3DX88|uniprotkb:D3DX92|ensembl:ENSP00000363304	intact:EBI-15666323|uniprotkb:A1A5L4	psi-mi:mk08_human(display_long)|uniprotkb:MAPK8(gene name)|psi-mi:MAPK8(display_short)|uniprotkb:JNK1(gene name synonym)|uniprotkb:PRKM8(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 1(gene name synonym)|uniprotkb:JNK-46(gene name synonym)|uniprotkb:SAPK1(gene name synonym)|uniprotkb:Stress-activated protein kinase 1c(gene name synonym)|uniprotkb:SAPK1C(gene name synonym)	psi-mi:aqp2_rat(display_long)|uniprotkb:Aqp2(gene name)|psi-mi:Aqp2(display_short)|uniprotkb:ADH water channel(gene name synonym)|uniprotkb:Aquaporin-CD(gene name synonym)|uniprotkb:Collecting duct water channel protein(gene name synonym)|uniprotkb:WCH-CD(gene name synonym)|uniprotkb:Water channel protein for renal collecting duct(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Rinschen et al. (2010)	pubmed:20139300|doi:10.1073/pnas.0910646107|imex:IM-17418	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15834230|imex:IM-17418-2|dip:DIP-188315E	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620634.1|refseq:NP_620637.1|refseq:NP_001310231.1|refseq:NP_001310250.1|refseq:NP_001310251.1|refseq:NP_001310252.1|refseq:NP_001310253.1|refseq:NP_001310254.1|refseq:NP_001310255.1|refseq:NP_001310256.1|refseq:NP_001310257.1|refseq:NP_001310258.1|refseq:NP_001310259.1|refseq:NP_001310260.1|refseq:NP_001265476.1|refseq:NP_001265477.1|dip:DIP-249N|ensembl:ENSG00000107643(gene)|ensembl:ENST00000374189(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0009411"(response to UV)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031343"(positive regulation of cell killing)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0048511"(rhythmic process)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:0090398"(cellular senescence)|go:"GO:0097441"(basal dendrite)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1902595"(regulation of DNA replication origin binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|mint:P45983|rcsb pdb:1UKH|rcsb pdb:1UKI|rcsb pdb:2G01|rcsb pdb:2GMX|rcsb pdb:2H96|rcsb pdb:2NO3|rcsb pdb:2XRW|rcsb pdb:2XS0|rcsb pdb:3ELJ|rcsb pdb:3O17|rcsb pdb:3O2M|rcsb pdb:3PZE|rcsb pdb:3V3V|rcsb pdb:3VUD|rcsb pdb:3VUG|rcsb pdb:3VUH|rcsb pdb:3VUI|rcsb pdb:3VUK|rcsb pdb:3VUL|rcsb pdb:3VUM|rcsb pdb:4AWI|rcsb pdb:4E73|rcsb pdb:4G1W|rcsb pdb:4HYS|rcsb pdb:4HYU|rcsb pdb:4IZY|rcsb pdb:4L7F|rcsb pdb:4QTD|rcsb pdb:4UX9|rcsb pdb:4YR8|rcsb pdb:5LW1|rcsb pdb:6F5E|rcsb pdb:6ZR5|reactome:R-HSA-111446|reactome:R-HSA-139910|reactome:R-HSA-193648|reactome:R-HSA-205043|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-376172|reactome:R-HSA-450321|reactome:R-HSA-450341|reactome:R-HSA-5693565|reactome:R-HSA-9007892|reactome:R-HSA-9673324	go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0003779"(actin binding)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0009414"(response to water deprivation)|go:"GO:0009651"(response to salt stress)|go:"GO:0009725"(response to hormone)|go:"GO:0010226"(response to lithium ion)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015793"(glycerol transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030104"(water homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033762"(response to glucagon)|go:"GO:0042594"(response to starvation)|go:"GO:0042631"(cellular response to water deprivation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0098576"(lumenal side of membrane)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR034294|go:"GO:0030042"(actin filament depolymerization)|reactome:R-RNO-432040|reactome:R-RNO-432047|rgd:2142|refseq:NP_037041.2|dip:DIP-46223N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:8FsGgIJWzsgWymaBqL5+0eQ/7qM9606	rogid:bl4TiOnSKu5JbanszX6ncsM96+g10116	rigid:UatL+cVOyN2TxdWeXTwkuyYivNo	false	-	binding-associated region:241-271|O-phospho-L-serine:261-261	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27361	uniprotkb:P34080	intact:EBI-73995|uniprotkb:B0LPG3|uniprotkb:A8CZ58|uniprotkb:Q8NHX1|ensembl:ENSP00000263025	intact:EBI-15666323|uniprotkb:A1A5L4	psi-mi:mk03_human(display_long)|uniprotkb:ERT2(gene name synonym)|uniprotkb:MAP kinase isoform p44(gene name synonym)|uniprotkb:Microtubule-associated protein 2 kinase(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 1(gene name synonym)|uniprotkb:Insulin-stimulated MAP2 kinase(gene name synonym)|uniprotkb:p44-ERK1(gene name synonym)|uniprotkb:MAPK3(gene name)|psi-mi:MAPK3(display_short)|uniprotkb:ERK1(gene name synonym)|uniprotkb:PRKM3(gene name synonym)	psi-mi:aqp2_rat(display_long)|uniprotkb:Aqp2(gene name)|psi-mi:Aqp2(display_short)|uniprotkb:ADH water channel(gene name synonym)|uniprotkb:Aquaporin-CD(gene name synonym)|uniprotkb:Collecting duct water channel protein(gene name synonym)|uniprotkb:WCH-CD(gene name synonym)|uniprotkb:Water channel protein for renal collecting duct(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Rinschen et al. (2010)	pubmed:20139300|doi:10.1073/pnas.0910646107|imex:IM-17418	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15834251|imex:IM-17418-3|dip:DIP-188316E	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035145.1|refseq:NP_001103361.1|refseq:NP_002737.2|dip:DIP-30985N|ensembl:ENSG00000102882(gene)|ensembl:ENST00000263025(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000657"(negative regulation of apolipoprotein binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P27361|rcsb pdb:2ZOQ|rcsb pdb:4QTB|rcsb pdb:6GES|reactome:R-HSA-110056|reactome:R-HSA-112409|reactome:R-HSA-1169408|reactome:R-HSA-1295596|reactome:R-HSA-162658|reactome:R-HSA-170968|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2029482|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2871796|reactome:R-HSA-3371453|reactome:R-HSA-375165|reactome:R-HSA-444257|reactome:R-HSA-445144|reactome:R-HSA-450341|reactome:R-HSA-456926|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5663213|reactome:R-HSA-5668599|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-73728|reactome:R-HSA-74749|reactome:R-HSA-879415|reactome:R-HSA-881907|reactome:R-HSA-8939211|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9627069|reactome:R-HSA-9634638|reactome:R-HSA-9635465|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|reactome:R-HSA-9664422|reactome:R-HSA-982772|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)	go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0003779"(actin binding)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0009414"(response to water deprivation)|go:"GO:0009651"(response to salt stress)|go:"GO:0009725"(response to hormone)|go:"GO:0010226"(response to lithium ion)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015793"(glycerol transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030104"(water homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033762"(response to glucagon)|go:"GO:0042594"(response to starvation)|go:"GO:0042631"(cellular response to water deprivation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0098576"(lumenal side of membrane)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR034294|go:"GO:0030042"(actin filament depolymerization)|reactome:R-RNO-432040|reactome:R-RNO-432047|rgd:2142|refseq:NP_037041.2|dip:DIP-46223N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:PGxmRMz0kOsJTfdn21FBiF33YwI9606	rogid:bl4TiOnSKu5JbanszX6ncsM96+g10116	rigid:W5k9xSCB93gz9yBX6Bxp3OqS76Q	false	-	binding-associated region:241-271|O-phospho-L-serine:261-261	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)