#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P70302	uniprotkb:P70302	intact:EBI-8402335|intact:MINT-4135875|uniprotkb:Q8K1E1|ensembl:ENSMUSP00000033289	intact:EBI-8402335|intact:MINT-4135875|uniprotkb:Q8K1E1|ensembl:ENSMUSP00000033289	psi-mi:stim1_mouse(display_long)|uniprotkb:Stim1(gene name)|psi-mi:Stim1(display_short)|uniprotkb:Sim(gene name synonym)	psi-mi:stim1_mouse(display_long)|uniprotkb:Stim1(gene name)|psi-mi:Stim1(display_short)|uniprotkb:Sim(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Zhou et al. (2010)	pubmed:20037597|doi:10.1038/nsmb.1724|imex:IM-14676	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15824963|imex:IM-14676-1|dip:DIP-103691E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033313.2|dip:DIP-48770N|ensembl:ENSMUSG00000030987(gene)|ensembl:ENSMUST00000033289(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0014902"(myotube differentiation)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030426"(growth cone)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070166"(enamel mineralization)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030463|interpro:IPR032393|interpro:IPR037608|interpro:IPR037609|mint:P70302|reactome:R-MMU-5578775|reactome:R-MMU-983695	refseq:NP_033313.2|dip:DIP-48770N|ensembl:ENSMUSG00000030987(gene)|ensembl:ENSMUST00000033289(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0014902"(myotube differentiation)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030426"(growth cone)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070166"(enamel mineralization)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030463|interpro:IPR032393|interpro:IPR037608|interpro:IPR037609|mint:P70302|reactome:R-MMU-5578775|reactome:R-MMU-983695	psi-mi:"MI:0465"(dip)	comment:mint|function:"Plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1"	comment:mint|function:"Plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/06	2017/08/10	rogid:V+owewlh5laiuVG+yfXlb9gZpV410090	rogid:V+owewlh5laiuVG+yfXlb9gZpV410090	rigid:NEIjkAjm8wbmaqZGxSVAXyVLHJM	false	sufficient binding region:233-463	sufficient binding region:233-463	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P70302	uniprotkb:P70302	intact:EBI-8402335|intact:MINT-4135875|uniprotkb:Q8K1E1|ensembl:ENSMUSP00000033289	intact:EBI-8402335|intact:MINT-4135875|uniprotkb:Q8K1E1|ensembl:ENSMUSP00000033289	psi-mi:stim1_mouse(display_long)|uniprotkb:Stim1(gene name)|psi-mi:Stim1(display_short)|uniprotkb:Sim(gene name synonym)	psi-mi:stim1_mouse(display_long)|uniprotkb:Stim1(gene name)|psi-mi:Stim1(display_short)|uniprotkb:Sim(gene name synonym)	psi-mi:"MI:0067"(light scattering)	Zhou et al. (2010)	pubmed:20037597|doi:10.1038/nsmb.1724|imex:IM-14676	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15824981|imex:IM-14676-2|dip:DIP-103691E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033313.2|dip:DIP-48770N|ensembl:ENSMUSG00000030987(gene)|ensembl:ENSMUST00000033289(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0014902"(myotube differentiation)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030426"(growth cone)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070166"(enamel mineralization)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030463|interpro:IPR032393|interpro:IPR037608|interpro:IPR037609|mint:P70302|reactome:R-MMU-5578775|reactome:R-MMU-983695	refseq:NP_033313.2|dip:DIP-48770N|ensembl:ENSMUSG00000030987(gene)|ensembl:ENSMUST00000033289(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0014902"(myotube differentiation)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030426"(growth cone)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070166"(enamel mineralization)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030463|interpro:IPR032393|interpro:IPR037608|interpro:IPR037609|mint:P70302|reactome:R-MMU-5578775|reactome:R-MMU-983695	psi-mi:"MI:0465"(dip)	comment:mint|function:"Plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1"	comment:mint|function:"Plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/06	2017/08/10	rogid:V+owewlh5laiuVG+yfXlb9gZpV410090	rogid:V+owewlh5laiuVG+yfXlb9gZpV410090	rigid:NEIjkAjm8wbmaqZGxSVAXyVLHJM	false	sufficient binding region:233-463	sufficient binding region:233-463	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P70302	uniprotkb:Q96D31	intact:EBI-8402335|intact:MINT-4135875|uniprotkb:Q8K1E1|ensembl:ENSMUSP00000033289	intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568	psi-mi:stim1_mouse(display_long)|uniprotkb:Stim1(gene name)|psi-mi:Stim1(display_short)|uniprotkb:Sim(gene name synonym)	psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhou et al. (2010)	pubmed:20037597|doi:10.1038/nsmb.1724|imex:IM-14676	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15824999|imex:IM-14676-3|dip:DIP-103692E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033313.2|dip:DIP-48770N|ensembl:ENSMUSG00000030987(gene)|ensembl:ENSMUST00000033289(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0014902"(myotube differentiation)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030426"(growth cone)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070166"(enamel mineralization)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030463|interpro:IPR032393|interpro:IPR037608|interpro:IPR037609|mint:P70302|reactome:R-MMU-5578775|reactome:R-MMU-983695	refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N	psi-mi:"MI:0465"(dip)	comment:mint|function:"Plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:V+owewlh5laiuVG+yfXlb9gZpV410090	rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606	rigid:2yM/yl4qkr3yVuGwJ+4kcxXsG7Q	false	sufficient binding region:233-498	sufficient binding region:65-87|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)