#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P16671	uniprotkb:Q9Y2C9	intact:EBI-2808214|uniprotkb:D9IX66|uniprotkb:D9IX67|uniprotkb:D9IX68|uniprotkb:D9IX69|ensembl:ENSP00000308165|ensembl:ENSP00000378268|ensembl:ENSP00000399421|ensembl:ENSP00000411411|ensembl:ENSP00000415743|uniprotkb:Q9BQC2|uniprotkb:Q9BPZ8|uniprotkb:Q9BZN5|uniprotkb:Q9BZM8|uniprotkb:Q8TCV7|uniprotkb:Q9BZN3|uniprotkb:Q16093|uniprotkb:Q13966|uniprotkb:Q9BZN4	intact:EBI-13940779|ensembl:ENSP00000371376|ensembl:ENSP00000389600|uniprotkb:B3Y640|uniprotkb:B6CH35|uniprotkb:B6RFS4|uniprotkb:B6RFS5|uniprotkb:Q2NKL3	psi-mi:cd36_human(display_long)|uniprotkb:GP3B(gene name synonym)|uniprotkb:GP4(gene name synonym)|uniprotkb:Platelet glycoprotein IV(gene name synonym)|uniprotkb:Glycoprotein IIIb(gene name synonym)|uniprotkb:Leukocyte differentiation antigen CD36(gene name synonym)|uniprotkb:PAS IV(gene name synonym)|uniprotkb:PAS-4(gene name synonym)|uniprotkb:Platelet collagen receptor(gene name synonym)|uniprotkb:Fatty acid translocase(gene name synonym)|uniprotkb:Thrombospondin receptor(gene name synonym)|uniprotkb:CD36(gene name)|psi-mi:CD36(display_short)	psi-mi:tlr6_human(display_long)|uniprotkb:TLR6(gene name)|psi-mi:TLR6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Stewart et al. (2010)	pubmed:20037584|imex:IM-25571	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13940775|imex:IM-25571-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:1901480"(oleate transmembrane transporter activity)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:1990379"(lipid transport across blood-brain barrier)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071944"(cell periphery)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098900"(regulation of action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150024"(oxidised low-density lipoprotein particle clearance)|go:"GO:0150025"(oxidised low-density lipoprotein particle receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|interpro:IPR002159(CD36 antigen)|interpro:IPR005428(Adhesion molecule CD36)|interpro:IPR033076|rcsb pdb:5LGD|reactome:R-HSA-114608|reactome:R-HSA-1236973|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-168188|reactome:R-HSA-1989781|reactome:R-HSA-3000471|reactome:R-HSA-381340|go:"GO:2000121"(regulation of removal of superoxide radicals)|reactome:R-HSA-434313|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6785807|reactome:R-HSA-6798695|ensembl:ENST00000447544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007596"(blood coagulation)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009897"(external side of plasma membrane)|ensembl:ENSG00000135218(gene)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015636"(short-chain fatty acid transmembrane transporter activity)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0015912"(short-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019915"(lipid storage)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030169"(low-density lipoprotein particle binding)|ensembl:ENST00000309881(transcript)|ensembl:ENST00000394788(transcript)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030666"(endocytic vesicle membrane)|ensembl:ENST00000432207(transcript)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|ensembl:ENST00000435819(transcript)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033993"(response to lipid)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070508"(cholesterol import)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070892"(lipoteichoic acid immune receptor activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0035634"(response to stilbenoid)|refseq:NP_000063.2|refseq:NP_001001547.1|refseq:NP_001001548.1|refseq:NP_001120915.1|refseq:NP_001120916.1|refseq:XP_005250770.1|refseq:XP_005250771.1|refseq:XP_005250772.1|refseq:NP_001276837.1|refseq:NP_001276838.1|refseq:NP_001276840.1	ensembl:ENSG00000174130(gene)|ensembl:ENST00000381950(transcript)|ensembl:ENST00000436693(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034150"(toll-like receptor 6 signaling pathway)|go:"GO:0035355"(Toll-like receptor 2-Toll-like receptor 6 protein complex)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027187|interpro:IPR032675|interpro:IPR035897|rcsb pdb:4OM7|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-168188|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|refseq:NP_006059.2|refseq:XP_005262694.1|refseq:XP_011511914.1|refseq:XP_011511915.1|refseq:XP_011511916.1	-	-	-	figure legend:5 A/B, 6E|agonist:oxidized LDL|agonist:amyloid-beta peptide, amino acids 1–42|antagonist:"The authors state that \"treatment with the Lyn kinase inhibitor PP1...blocked the physical association of CD36 with TLR4 and TLR6 in oxLDL-treated monocytes\"."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2017/02/16	2017/03/01	rogid:aYX4Uyq9gXqLN3pgTWyKWGQmL5w9606	rogid:ZxUgLMp8135g2wNoVV2aRrwE0NU9606	rigid:9WLfCTYZJJYe7b7zw8VdjgPSYCU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16671	uniprotkb:O00206	intact:EBI-2808214|uniprotkb:D9IX66|uniprotkb:D9IX67|uniprotkb:D9IX68|uniprotkb:D9IX69|ensembl:ENSP00000308165|ensembl:ENSP00000378268|ensembl:ENSP00000399421|ensembl:ENSP00000411411|ensembl:ENSP00000415743|uniprotkb:Q9BQC2|uniprotkb:Q9BPZ8|uniprotkb:Q9BZN5|uniprotkb:Q9BZM8|uniprotkb:Q8TCV7|uniprotkb:Q9BZN3|uniprotkb:Q16093|uniprotkb:Q13966|uniprotkb:Q9BZN4	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	psi-mi:cd36_human(display_long)|uniprotkb:GP3B(gene name synonym)|uniprotkb:GP4(gene name synonym)|uniprotkb:Platelet glycoprotein IV(gene name synonym)|uniprotkb:Glycoprotein IIIb(gene name synonym)|uniprotkb:Leukocyte differentiation antigen CD36(gene name synonym)|uniprotkb:PAS IV(gene name synonym)|uniprotkb:PAS-4(gene name synonym)|uniprotkb:Platelet collagen receptor(gene name synonym)|uniprotkb:Fatty acid translocase(gene name synonym)|uniprotkb:Thrombospondin receptor(gene name synonym)|uniprotkb:CD36(gene name)|psi-mi:CD36(display_short)	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Stewart et al. (2010)	pubmed:20037584|imex:IM-25571	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13940775|imex:IM-25571-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:1901480"(oleate transmembrane transporter activity)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:1990379"(lipid transport across blood-brain barrier)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071944"(cell periphery)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098900"(regulation of action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150024"(oxidised low-density lipoprotein particle clearance)|go:"GO:0150025"(oxidised low-density lipoprotein particle receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|interpro:IPR002159(CD36 antigen)|interpro:IPR005428(Adhesion molecule CD36)|interpro:IPR033076|rcsb pdb:5LGD|reactome:R-HSA-114608|reactome:R-HSA-1236973|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-168188|reactome:R-HSA-1989781|reactome:R-HSA-3000471|reactome:R-HSA-381340|go:"GO:2000121"(regulation of removal of superoxide radicals)|reactome:R-HSA-434313|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6785807|reactome:R-HSA-6798695|ensembl:ENST00000447544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007596"(blood coagulation)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009897"(external side of plasma membrane)|ensembl:ENSG00000135218(gene)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015636"(short-chain fatty acid transmembrane transporter activity)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0015912"(short-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019915"(lipid storage)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030169"(low-density lipoprotein particle binding)|ensembl:ENST00000309881(transcript)|ensembl:ENST00000394788(transcript)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030666"(endocytic vesicle membrane)|ensembl:ENST00000432207(transcript)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|ensembl:ENST00000435819(transcript)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033993"(response to lipid)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070508"(cholesterol import)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070892"(lipoteichoic acid immune receptor activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0035634"(response to stilbenoid)|refseq:NP_000063.2|refseq:NP_001001547.1|refseq:NP_001001548.1|refseq:NP_001120915.1|refseq:NP_001120916.1|refseq:XP_005250770.1|refseq:XP_005250771.1|refseq:XP_005250772.1|refseq:NP_001276837.1|refseq:NP_001276838.1|refseq:NP_001276840.1	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	-	-	-	figure legend:5 A/B, 6E|agonist:oxidized LDL|agonist:amyloid-beta peptide, amino acids 1–42|antagonist:"The authors state that \"treatment with the Lyn kinase inhibitor PP1...blocked the physical association of CD36 with TLR4 and TLR6 in oxLDL-treated monocytes\"."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2017/02/16	2017/03/01	rogid:aYX4Uyq9gXqLN3pgTWyKWGQmL5w9606	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rigid:9WLfCTYZJJYe7b7zw8VdjgPSYCU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q08857	uniprotkb:O00206	intact:EBI-8346984|intact:MINT-4090233|ensembl:ENSMUSP00000080974|ensembl:ENSMUSP00000126300|ensembl:ENSMUSP00000131832|ensembl:ENSMUSP00000133008|ensembl:ENSMUSP00000143061	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	psi-mi:cd36_mouse(display_long)|uniprotkb:Cd36(gene name)|psi-mi:Cd36(display_short)|uniprotkb:Platelet glycoprotein IV(gene name synonym)|uniprotkb:PAS IV(gene name synonym)|uniprotkb:PAS-4(gene name synonym)|uniprotkb:Glycoprotein IIIb(gene name synonym)	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Stewart et al. (2010)	pubmed:20037584|imex:IM-25571	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13940872|imex:IM-25571-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031669.3|refseq:NP_001153028.1|refseq:NP_001153030.1|refseq:NP_001153027.1|refseq:NP_001153029.1|refseq:XP_006535683.1|refseq:XP_006535684.1|refseq:XP_006535685.1|refseq:XP_006535686.1|refseq:XP_006535687.1|refseq:XP_006535688.1|ensembl:ENSMUSG00000002944(gene)|ensembl:ENSMUST00000082367(transcript)|ensembl:ENSMUST00000165232(transcript)|ensembl:ENSMUST00000169095(transcript)|ensembl:ENSMUST00000170051(transcript)|ensembl:ENSMUST00000197890(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015636"(short-chain fatty acid transmembrane transporter activity)|go:"GO:0015908"(fatty acid transport)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0015912"(short-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019915"(lipid storage)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031526"(brush border membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033993"(response to lipid)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070508"(cholesterol import)|go:"GO:0070538"(oleic acid binding)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070892"(lipoteichoic acid immune receptor activity)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090208"(positive regulation of triglyceride metabolic process)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098900"(regulation of action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150024"(oxidised low-density lipoprotein particle clearance)|go:"GO:0150025"(oxidised low-density lipoprotein particle receptor activity)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901480"(oleate transmembrane transporter activity)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990379"(lipid transport across blood-brain barrier)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR002159(CD36 antigen)|interpro:IPR005428(Adhesion molecule CD36)|interpro:IPR033076|mint:Q08857|reactome:R-MMU-114608|reactome:R-MMU-1236973|reactome:R-MMU-3000471|reactome:R-MMU-434313|reactome:R-MMU-5686938|reactome:R-MMU-6798695	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	go:"GO:0005622"(intracellular anatomical structure)	comment:mint|function:Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport	-	figure legend:5C|agonist:oxidized LDL|comment:Minimal colocalization of CD36, TLR4 and TLR6 was seen in resting cells, but upon treatment with oxLDL, CD36, TLR4 and TLR6 colocalized predominantly in intracellular compartments.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/02/16	2017/03/01	rogid:QDA1b0VEcVscBQlyYDRxFZMeAtg10090	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rigid:Ri2objPrl5h6YqvzqNIrWCPFK2U	false	-	yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q08857	uniprotkb:Q9Y2C9	intact:EBI-8346984|intact:MINT-4090233|ensembl:ENSMUSP00000080974|ensembl:ENSMUSP00000126300|ensembl:ENSMUSP00000131832|ensembl:ENSMUSP00000133008|ensembl:ENSMUSP00000143061	intact:EBI-13940779|ensembl:ENSP00000371376|ensembl:ENSP00000389600|uniprotkb:B3Y640|uniprotkb:B6CH35|uniprotkb:B6RFS4|uniprotkb:B6RFS5|uniprotkb:Q2NKL3	psi-mi:cd36_mouse(display_long)|uniprotkb:Cd36(gene name)|psi-mi:Cd36(display_short)|uniprotkb:Platelet glycoprotein IV(gene name synonym)|uniprotkb:PAS IV(gene name synonym)|uniprotkb:PAS-4(gene name synonym)|uniprotkb:Glycoprotein IIIb(gene name synonym)	psi-mi:tlr6_human(display_long)|uniprotkb:TLR6(gene name)|psi-mi:TLR6(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Stewart et al. (2010)	pubmed:20037584|imex:IM-25571	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13940872|imex:IM-25571-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031669.3|refseq:NP_001153028.1|refseq:NP_001153030.1|refseq:NP_001153027.1|refseq:NP_001153029.1|refseq:XP_006535683.1|refseq:XP_006535684.1|refseq:XP_006535685.1|refseq:XP_006535686.1|refseq:XP_006535687.1|refseq:XP_006535688.1|ensembl:ENSMUSG00000002944(gene)|ensembl:ENSMUST00000082367(transcript)|ensembl:ENSMUST00000165232(transcript)|ensembl:ENSMUST00000169095(transcript)|ensembl:ENSMUST00000170051(transcript)|ensembl:ENSMUST00000197890(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015636"(short-chain fatty acid transmembrane transporter activity)|go:"GO:0015908"(fatty acid transport)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0015912"(short-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019915"(lipid storage)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031526"(brush border membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033993"(response to lipid)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070508"(cholesterol import)|go:"GO:0070538"(oleic acid binding)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070892"(lipoteichoic acid immune receptor activity)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090208"(positive regulation of triglyceride metabolic process)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098900"(regulation of action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150024"(oxidised low-density lipoprotein particle clearance)|go:"GO:0150025"(oxidised low-density lipoprotein particle receptor activity)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901480"(oleate transmembrane transporter activity)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990379"(lipid transport across blood-brain barrier)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR002159(CD36 antigen)|interpro:IPR005428(Adhesion molecule CD36)|interpro:IPR033076|mint:Q08857|reactome:R-MMU-114608|reactome:R-MMU-1236973|reactome:R-MMU-3000471|reactome:R-MMU-434313|reactome:R-MMU-5686938|reactome:R-MMU-6798695	ensembl:ENSG00000174130(gene)|ensembl:ENST00000381950(transcript)|ensembl:ENST00000436693(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034150"(toll-like receptor 6 signaling pathway)|go:"GO:0035355"(Toll-like receptor 2-Toll-like receptor 6 protein complex)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027187|interpro:IPR032675|interpro:IPR035897|rcsb pdb:4OM7|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-168188|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|refseq:NP_006059.2|refseq:XP_005262694.1|refseq:XP_011511914.1|refseq:XP_011511915.1|refseq:XP_011511916.1	go:"GO:0005622"(intracellular anatomical structure)	comment:mint|function:Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport	-	figure legend:5C|agonist:oxidized LDL|comment:Minimal colocalization of CD36, TLR4 and TLR6 was seen in resting cells, but upon treatment with oxLDL, CD36, TLR4 and TLR6 colocalized predominantly in intracellular compartments.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/02/16	2017/03/01	rogid:QDA1b0VEcVscBQlyYDRxFZMeAtg10090	rogid:ZxUgLMp8135g2wNoVV2aRrwE0NU9606	rigid:Ri2objPrl5h6YqvzqNIrWCPFK2U	false	-	cyan fluorescent protein tag:c-c	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:O00206	uniprotkb:Q08857	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	intact:EBI-8346984|intact:MINT-4090233|ensembl:ENSMUSP00000080974|ensembl:ENSMUSP00000126300|ensembl:ENSMUSP00000131832|ensembl:ENSMUSP00000133008|ensembl:ENSMUSP00000143061	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:cd36_mouse(display_long)|uniprotkb:Cd36(gene name)|psi-mi:Cd36(display_short)|uniprotkb:Platelet glycoprotein IV(gene name synonym)|uniprotkb:PAS IV(gene name synonym)|uniprotkb:PAS-4(gene name synonym)|uniprotkb:Glycoprotein IIIb(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Stewart et al. (2010)	pubmed:20037584|imex:IM-25571	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13940896|imex:IM-25571-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	refseq:NP_031669.3|refseq:NP_001153028.1|refseq:NP_001153030.1|refseq:NP_001153027.1|refseq:NP_001153029.1|refseq:XP_006535683.1|refseq:XP_006535684.1|refseq:XP_006535685.1|refseq:XP_006535686.1|refseq:XP_006535687.1|refseq:XP_006535688.1|ensembl:ENSMUSG00000002944(gene)|ensembl:ENSMUST00000082367(transcript)|ensembl:ENSMUST00000165232(transcript)|ensembl:ENSMUST00000169095(transcript)|ensembl:ENSMUST00000170051(transcript)|ensembl:ENSMUST00000197890(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015636"(short-chain fatty acid transmembrane transporter activity)|go:"GO:0015908"(fatty acid transport)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0015912"(short-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019915"(lipid storage)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031526"(brush border membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033993"(response to lipid)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070508"(cholesterol import)|go:"GO:0070538"(oleic acid binding)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070892"(lipoteichoic acid immune receptor activity)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090208"(positive regulation of triglyceride metabolic process)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098900"(regulation of action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150024"(oxidised low-density lipoprotein particle clearance)|go:"GO:0150025"(oxidised low-density lipoprotein particle receptor activity)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901480"(oleate transmembrane transporter activity)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990379"(lipid transport across blood-brain barrier)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR002159(CD36 antigen)|interpro:IPR005428(Adhesion molecule CD36)|interpro:IPR033076|mint:Q08857|reactome:R-MMU-114608|reactome:R-MMU-1236973|reactome:R-MMU-3000471|reactome:R-MMU-434313|reactome:R-MMU-5686938|reactome:R-MMU-6798695	-	-	comment:mint|function:Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport	figure legend:6B|agonist:oxidized LDL|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/02/16	2017/03/01	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rogid:QDA1b0VEcVscBQlyYDRxFZMeAtg10090	rigid:Ri2objPrl5h6YqvzqNIrWCPFK2U	false	yellow fluorescent protein tag:c-c	mutation disrupting interaction strength:463-463	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:O00206	uniprotkb:Q9Y2C9	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	intact:EBI-13940779|ensembl:ENSP00000371376|ensembl:ENSP00000389600|uniprotkb:B3Y640|uniprotkb:B6CH35|uniprotkb:B6RFS4|uniprotkb:B6RFS5|uniprotkb:Q2NKL3	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:tlr6_human(display_long)|uniprotkb:TLR6(gene name)|psi-mi:TLR6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Stewart et al. (2010)	pubmed:20037584|imex:IM-25571	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13940896|imex:IM-25571-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	ensembl:ENSG00000174130(gene)|ensembl:ENST00000381950(transcript)|ensembl:ENST00000436693(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034150"(toll-like receptor 6 signaling pathway)|go:"GO:0035355"(Toll-like receptor 2-Toll-like receptor 6 protein complex)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027187|interpro:IPR032675|interpro:IPR035897|rcsb pdb:4OM7|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-168188|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|refseq:NP_006059.2|refseq:XP_005262694.1|refseq:XP_011511914.1|refseq:XP_011511915.1|refseq:XP_011511916.1	-	-	-	figure legend:6B|agonist:oxidized LDL|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/02/16	2017/03/01	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rogid:ZxUgLMp8135g2wNoVV2aRrwE0NU9606	rigid:Ri2objPrl5h6YqvzqNIrWCPFK2U	false	yellow fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00206	uniprotkb:Q9Y2C9	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	intact:EBI-13940779|ensembl:ENSP00000371376|ensembl:ENSP00000389600|uniprotkb:B3Y640|uniprotkb:B6CH35|uniprotkb:B6RFS4|uniprotkb:B6RFS5|uniprotkb:Q2NKL3	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:tlr6_human(display_long)|uniprotkb:TLR6(gene name)|psi-mi:TLR6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Stewart et al. (2010)	pubmed:20037584|imex:IM-25571	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13951319|imex:IM-25571-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	ensembl:ENSG00000174130(gene)|ensembl:ENST00000381950(transcript)|ensembl:ENST00000436693(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034150"(toll-like receptor 6 signaling pathway)|go:"GO:0035355"(Toll-like receptor 2-Toll-like receptor 6 protein complex)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027187|interpro:IPR032675|interpro:IPR035897|rcsb pdb:4OM7|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-168188|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|refseq:NP_006059.2|refseq:XP_005262694.1|refseq:XP_011511914.1|refseq:XP_011511915.1|refseq:XP_011511916.1	-	-	-	figure legend:6B lane 2|comment:very weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/02/16	2017/03/20	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rogid:ZxUgLMp8135g2wNoVV2aRrwE0NU9606	rigid:gF1eZGcIeegnag1PxBnmGrgBICo	false	yellow fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q08857	uniprotkb:P07948	intact:EBI-8346984|intact:MINT-4090233|ensembl:ENSMUSP00000080974|ensembl:ENSMUSP00000126300|ensembl:ENSMUSP00000131832|ensembl:ENSMUSP00000133008|ensembl:ENSMUSP00000143061	intact:EBI-79452|ensembl:ENSP00000428924|uniprotkb:A0AVQ5|intact:EBI-6868890	psi-mi:cd36_mouse(display_long)|uniprotkb:Cd36(gene name)|psi-mi:Cd36(display_short)|uniprotkb:Platelet glycoprotein IV(gene name synonym)|uniprotkb:PAS IV(gene name synonym)|uniprotkb:PAS-4(gene name synonym)|uniprotkb:Glycoprotein IIIb(gene name synonym)	psi-mi:lyn_human(display_long)|uniprotkb:JTK8(gene name synonym)|uniprotkb:Lck/Yes-related novel protein tyrosine kinase(gene name synonym)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)|uniprotkb:LYN(gene name)|psi-mi:LYN(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Stewart et al. (2010)	pubmed:20037584|imex:IM-25571	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13940921|imex:IM-25571-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031669.3|refseq:NP_001153028.1|refseq:NP_001153030.1|refseq:NP_001153027.1|refseq:NP_001153029.1|refseq:XP_006535683.1|refseq:XP_006535684.1|refseq:XP_006535685.1|refseq:XP_006535686.1|refseq:XP_006535687.1|refseq:XP_006535688.1|ensembl:ENSMUSG00000002944(gene)|ensembl:ENSMUST00000082367(transcript)|ensembl:ENSMUST00000165232(transcript)|ensembl:ENSMUST00000169095(transcript)|ensembl:ENSMUST00000170051(transcript)|ensembl:ENSMUST00000197890(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015636"(short-chain fatty acid transmembrane transporter activity)|go:"GO:0015908"(fatty acid transport)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0015912"(short-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019915"(lipid storage)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031526"(brush border membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033993"(response to lipid)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070508"(cholesterol import)|go:"GO:0070538"(oleic acid binding)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070892"(lipoteichoic acid immune receptor activity)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090208"(positive regulation of triglyceride metabolic process)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098900"(regulation of action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150024"(oxidised low-density lipoprotein particle clearance)|go:"GO:0150025"(oxidised low-density lipoprotein particle receptor activity)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901480"(oleate transmembrane transporter activity)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990379"(lipid transport across blood-brain barrier)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR002159(CD36 antigen)|interpro:IPR005428(Adhesion molecule CD36)|interpro:IPR033076|mint:Q08857|reactome:R-MMU-114608|reactome:R-MMU-1236973|reactome:R-MMU-3000471|reactome:R-MMU-434313|reactome:R-MMU-5686938|reactome:R-MMU-6798695	refseq:NP_001104567.1|refseq:NP_002341.1|ensembl:ENSG00000254087(gene)|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983695|reactome:R-HSA-9664323|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|ensembl:ENST00000519728(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032868"(response to insulin)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P07948|rcsb pdb:1W1F|rcsb pdb:1WA7|go:"GO:0099091"(postsynaptic specialization, intracellular component)|rcsb pdb:5XY1|rcsb pdb:6NMW|reactome:R-HSA-114604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2454202|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-5621480|rcsb pdb:3A4O|reactome:R-HSA-5621575|reactome:R-HSA-5690714|reactome:R-HSA-69231|reactome:R-HSA-75892|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:XP_016868905.1|dip:DIP-1056N	-	comment:mint|function:Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport	-	figure legend:6C-top|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/02/16	2021/07/09	rogid:QDA1b0VEcVscBQlyYDRxFZMeAtg10090	rogid:SqXPSC+g2ZuGHy6TAPV4HcpXe6U9606	rigid:Xk+Z2UHDdZxRIOlQI/xW5QZCDwY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q08857	uniprotkb:P49023	intact:EBI-8346984|intact:MINT-4090233|ensembl:ENSMUSP00000080974|ensembl:ENSMUSP00000126300|ensembl:ENSMUSP00000131832|ensembl:ENSMUSP00000133008|ensembl:ENSMUSP00000143061	intact:EBI-702209|uniprotkb:O14970|uniprotkb:O14971|uniprotkb:O60360|uniprotkb:B2RAI3|uniprotkb:Q5HYA4|uniprotkb:B7ZMB4|ensembl:ENSP00000228307	psi-mi:cd36_mouse(display_long)|uniprotkb:Cd36(gene name)|psi-mi:Cd36(display_short)|uniprotkb:Platelet glycoprotein IV(gene name synonym)|uniprotkb:PAS IV(gene name synonym)|uniprotkb:PAS-4(gene name synonym)|uniprotkb:Glycoprotein IIIb(gene name synonym)	psi-mi:paxi_human(display_long)|uniprotkb:PXN(gene name)|psi-mi:PXN(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Stewart et al. (2010)	pubmed:20037584|imex:IM-25571	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13941173|imex:IM-25571-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031669.3|refseq:NP_001153028.1|refseq:NP_001153030.1|refseq:NP_001153027.1|refseq:NP_001153029.1|refseq:XP_006535683.1|refseq:XP_006535684.1|refseq:XP_006535685.1|refseq:XP_006535686.1|refseq:XP_006535687.1|refseq:XP_006535688.1|ensembl:ENSMUSG00000002944(gene)|ensembl:ENSMUST00000082367(transcript)|ensembl:ENSMUST00000165232(transcript)|ensembl:ENSMUST00000169095(transcript)|ensembl:ENSMUST00000170051(transcript)|ensembl:ENSMUST00000197890(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015636"(short-chain fatty acid transmembrane transporter activity)|go:"GO:0015908"(fatty acid transport)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0015912"(short-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019915"(lipid storage)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031526"(brush border membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033993"(response to lipid)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070508"(cholesterol import)|go:"GO:0070538"(oleic acid binding)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070892"(lipoteichoic acid immune receptor activity)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090208"(positive regulation of triglyceride metabolic process)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098900"(regulation of action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150024"(oxidised low-density lipoprotein particle clearance)|go:"GO:0150025"(oxidised low-density lipoprotein particle receptor activity)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901480"(oleate transmembrane transporter activity)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990379"(lipid transport across blood-brain barrier)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR002159(CD36 antigen)|interpro:IPR005428(Adhesion molecule CD36)|interpro:IPR033076|mint:Q08857|reactome:R-MMU-114608|reactome:R-MMU-1236973|reactome:R-MMU-3000471|reactome:R-MMU-434313|reactome:R-MMU-5686938|reactome:R-MMU-6798695	refseq:NP_001074324.1|refseq:NP_002850.2|refseq:NP_079433.3|refseq:NP_001230685.1|refseq:XP_016875232.1|dip:DIP-33851N|ensembl:ENSG00000089159(gene)|ensembl:ENST00000228307(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0017166"(vinculin binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0038191"(neuropilin binding)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR001904(Paxillin)|mint:P49023|rcsb pdb:1KKY|rcsb pdb:1KL0|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2K2R|rcsb pdb:2O9V|rcsb pdb:2VZD|rcsb pdb:2VZG|rcsb pdb:2VZI|rcsb pdb:3GM1|rcsb pdb:3PY7|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3U3F|rcsb pdb:4EDN|rcsb pdb:4R32|rcsb pdb:4XGZ|rcsb pdb:4XH2|rcsb pdb:5UWH|rcsb pdb:6IUI|rcsb pdb:6PW8|rcsb pdb:6U4M|rcsb pdb:6U4N|reactome:R-HSA-180292|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-446343|reactome:R-HSA-446388|reactome:R-HSA-8849471	-	comment:mint|function:Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport	-	figure legend:Supp figure 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/02/16	2017/03/02	rogid:QDA1b0VEcVscBQlyYDRxFZMeAtg10090	rogid:H8osAQRrVydLfDL97uSSA6Mf6ME9606	rigid:8J9FBQgcvMwTUdsHXvQ9avT5Gz8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q08857	uniprotkb:P07948	intact:EBI-8346984|intact:MINT-4090233|ensembl:ENSMUSP00000080974|ensembl:ENSMUSP00000126300|ensembl:ENSMUSP00000131832|ensembl:ENSMUSP00000133008|ensembl:ENSMUSP00000143061	intact:EBI-79452|ensembl:ENSP00000428924|uniprotkb:A0AVQ5|intact:EBI-6868890	psi-mi:cd36_mouse(display_long)|uniprotkb:Cd36(gene name)|psi-mi:Cd36(display_short)|uniprotkb:Platelet glycoprotein IV(gene name synonym)|uniprotkb:PAS IV(gene name synonym)|uniprotkb:PAS-4(gene name synonym)|uniprotkb:Glycoprotein IIIb(gene name synonym)	psi-mi:lyn_human(display_long)|uniprotkb:JTK8(gene name synonym)|uniprotkb:Lck/Yes-related novel protein tyrosine kinase(gene name synonym)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)|uniprotkb:LYN(gene name)|psi-mi:LYN(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Stewart et al. (2010)	pubmed:20037584|imex:IM-25571	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13941173|imex:IM-25571-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031669.3|refseq:NP_001153028.1|refseq:NP_001153030.1|refseq:NP_001153027.1|refseq:NP_001153029.1|refseq:XP_006535683.1|refseq:XP_006535684.1|refseq:XP_006535685.1|refseq:XP_006535686.1|refseq:XP_006535687.1|refseq:XP_006535688.1|ensembl:ENSMUSG00000002944(gene)|ensembl:ENSMUST00000082367(transcript)|ensembl:ENSMUST00000165232(transcript)|ensembl:ENSMUST00000169095(transcript)|ensembl:ENSMUST00000170051(transcript)|ensembl:ENSMUST00000197890(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015636"(short-chain fatty acid transmembrane transporter activity)|go:"GO:0015908"(fatty acid transport)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0015912"(short-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019915"(lipid storage)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031526"(brush border membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033993"(response to lipid)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070508"(cholesterol import)|go:"GO:0070538"(oleic acid binding)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070892"(lipoteichoic acid immune receptor activity)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090208"(positive regulation of triglyceride metabolic process)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098900"(regulation of action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150024"(oxidised low-density lipoprotein particle clearance)|go:"GO:0150025"(oxidised low-density lipoprotein particle receptor activity)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901480"(oleate transmembrane transporter activity)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990379"(lipid transport across blood-brain barrier)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR002159(CD36 antigen)|interpro:IPR005428(Adhesion molecule CD36)|interpro:IPR033076|mint:Q08857|reactome:R-MMU-114608|reactome:R-MMU-1236973|reactome:R-MMU-3000471|reactome:R-MMU-434313|reactome:R-MMU-5686938|reactome:R-MMU-6798695	refseq:NP_001104567.1|refseq:NP_002341.1|ensembl:ENSG00000254087(gene)|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983695|reactome:R-HSA-9664323|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|ensembl:ENST00000519728(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032868"(response to insulin)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P07948|rcsb pdb:1W1F|rcsb pdb:1WA7|go:"GO:0099091"(postsynaptic specialization, intracellular component)|rcsb pdb:5XY1|rcsb pdb:6NMW|reactome:R-HSA-114604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2454202|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-5621480|rcsb pdb:3A4O|reactome:R-HSA-5621575|reactome:R-HSA-5690714|reactome:R-HSA-69231|reactome:R-HSA-75892|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:XP_016868905.1|dip:DIP-1056N	-	comment:mint|function:Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport	-	figure legend:Supp figure 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/02/16	2017/03/02	rogid:QDA1b0VEcVscBQlyYDRxFZMeAtg10090	rogid:SqXPSC+g2ZuGHy6TAPV4HcpXe6U9606	rigid:8J9FBQgcvMwTUdsHXvQ9avT5Gz8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16671	uniprotkb:P49023	intact:EBI-2808214|uniprotkb:D9IX66|uniprotkb:D9IX67|uniprotkb:D9IX68|uniprotkb:D9IX69|ensembl:ENSP00000308165|ensembl:ENSP00000378268|ensembl:ENSP00000399421|ensembl:ENSP00000411411|ensembl:ENSP00000415743|uniprotkb:Q9BQC2|uniprotkb:Q9BPZ8|uniprotkb:Q9BZN5|uniprotkb:Q9BZM8|uniprotkb:Q8TCV7|uniprotkb:Q9BZN3|uniprotkb:Q16093|uniprotkb:Q13966|uniprotkb:Q9BZN4	intact:EBI-702209|uniprotkb:O14970|uniprotkb:O14971|uniprotkb:O60360|uniprotkb:B2RAI3|uniprotkb:Q5HYA4|uniprotkb:B7ZMB4|ensembl:ENSP00000228307	psi-mi:cd36_human(display_long)|uniprotkb:GP3B(gene name synonym)|uniprotkb:GP4(gene name synonym)|uniprotkb:Platelet glycoprotein IV(gene name synonym)|uniprotkb:Glycoprotein IIIb(gene name synonym)|uniprotkb:Leukocyte differentiation antigen CD36(gene name synonym)|uniprotkb:PAS IV(gene name synonym)|uniprotkb:PAS-4(gene name synonym)|uniprotkb:Platelet collagen receptor(gene name synonym)|uniprotkb:Fatty acid translocase(gene name synonym)|uniprotkb:Thrombospondin receptor(gene name synonym)|uniprotkb:CD36(gene name)|psi-mi:CD36(display_short)	psi-mi:paxi_human(display_long)|uniprotkb:PXN(gene name)|psi-mi:PXN(display_short)	psi-mi:"MI:0096"(pull down)	Stewart et al. (2010)	pubmed:20037584|imex:IM-25571	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13940936|imex:IM-25571-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:1901480"(oleate transmembrane transporter activity)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:1990379"(lipid transport across blood-brain barrier)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071944"(cell periphery)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098900"(regulation of action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150024"(oxidised low-density lipoprotein particle clearance)|go:"GO:0150025"(oxidised low-density lipoprotein particle receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|interpro:IPR002159(CD36 antigen)|interpro:IPR005428(Adhesion molecule CD36)|interpro:IPR033076|rcsb pdb:5LGD|reactome:R-HSA-114608|reactome:R-HSA-1236973|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-168188|reactome:R-HSA-1989781|reactome:R-HSA-3000471|reactome:R-HSA-381340|go:"GO:2000121"(regulation of removal of superoxide radicals)|reactome:R-HSA-434313|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6785807|reactome:R-HSA-6798695|ensembl:ENST00000447544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007596"(blood coagulation)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009897"(external side of plasma membrane)|ensembl:ENSG00000135218(gene)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015636"(short-chain fatty acid transmembrane transporter activity)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0015912"(short-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019915"(lipid storage)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030169"(low-density lipoprotein particle binding)|ensembl:ENST00000309881(transcript)|ensembl:ENST00000394788(transcript)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030666"(endocytic vesicle membrane)|ensembl:ENST00000432207(transcript)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|ensembl:ENST00000435819(transcript)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033993"(response to lipid)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070508"(cholesterol import)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070892"(lipoteichoic acid immune receptor activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0035634"(response to stilbenoid)|refseq:NP_000063.2|refseq:NP_001001547.1|refseq:NP_001001548.1|refseq:NP_001120915.1|refseq:NP_001120916.1|refseq:XP_005250770.1|refseq:XP_005250771.1|refseq:XP_005250772.1|refseq:NP_001276837.1|refseq:NP_001276838.1|refseq:NP_001276840.1	refseq:NP_001074324.1|refseq:NP_002850.2|refseq:NP_079433.3|refseq:NP_001230685.1|refseq:XP_016875232.1|dip:DIP-33851N|ensembl:ENSG00000089159(gene)|ensembl:ENST00000228307(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0017166"(vinculin binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0038191"(neuropilin binding)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR001904(Paxillin)|mint:P49023|rcsb pdb:1KKY|rcsb pdb:1KL0|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2K2R|rcsb pdb:2O9V|rcsb pdb:2VZD|rcsb pdb:2VZG|rcsb pdb:2VZI|rcsb pdb:3GM1|rcsb pdb:3PY7|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3U3F|rcsb pdb:4EDN|rcsb pdb:4R32|rcsb pdb:4XGZ|rcsb pdb:4XH2|rcsb pdb:5UWH|rcsb pdb:6IUI|rcsb pdb:6PW8|rcsb pdb:6U4M|rcsb pdb:6U4N|reactome:R-HSA-180292|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-446343|reactome:R-HSA-446388|reactome:R-HSA-8849471	-	-	-	figure legend:Supp figure 4A|comment:Results from blasting the CD36 peptide sequence used for Pull down gives 100% homology with  Human CD36, but only ~90% with the Mouse protein.|comment:A protein of approximately 60 kDa was also pulled down- and shown to be Lyn..|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2017/03/02	rogid:aYX4Uyq9gXqLN3pgTWyKWGQmL5w9606	rogid:H8osAQRrVydLfDL97uSSA6Mf6ME9606	rigid:PyvCTc/ZteuwrKDPKorQzn4pDFQ	false	sufficient binding region:460-472|his tag:?-?	N-phosphorylated residue:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16671	uniprotkb:Q05397	intact:EBI-2808214|uniprotkb:D9IX66|uniprotkb:D9IX67|uniprotkb:D9IX68|uniprotkb:D9IX69|ensembl:ENSP00000308165|ensembl:ENSP00000378268|ensembl:ENSP00000399421|ensembl:ENSP00000411411|ensembl:ENSP00000415743|uniprotkb:Q9BQC2|uniprotkb:Q9BPZ8|uniprotkb:Q9BZN5|uniprotkb:Q9BZM8|uniprotkb:Q8TCV7|uniprotkb:Q9BZN3|uniprotkb:Q16093|uniprotkb:Q13966|uniprotkb:Q9BZN4	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	psi-mi:cd36_human(display_long)|uniprotkb:GP3B(gene name synonym)|uniprotkb:GP4(gene name synonym)|uniprotkb:Platelet glycoprotein IV(gene name synonym)|uniprotkb:Glycoprotein IIIb(gene name synonym)|uniprotkb:Leukocyte differentiation antigen CD36(gene name synonym)|uniprotkb:PAS IV(gene name synonym)|uniprotkb:PAS-4(gene name synonym)|uniprotkb:Platelet collagen receptor(gene name synonym)|uniprotkb:Fatty acid translocase(gene name synonym)|uniprotkb:Thrombospondin receptor(gene name synonym)|uniprotkb:CD36(gene name)|psi-mi:CD36(display_short)	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Stewart et al. (2010)	pubmed:20037584|imex:IM-25571	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13940936|imex:IM-25571-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:1901480"(oleate transmembrane transporter activity)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:1990379"(lipid transport across blood-brain barrier)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071944"(cell periphery)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098900"(regulation of action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150024"(oxidised low-density lipoprotein particle clearance)|go:"GO:0150025"(oxidised low-density lipoprotein particle receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|interpro:IPR002159(CD36 antigen)|interpro:IPR005428(Adhesion molecule CD36)|interpro:IPR033076|rcsb pdb:5LGD|reactome:R-HSA-114608|reactome:R-HSA-1236973|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-168188|reactome:R-HSA-1989781|reactome:R-HSA-3000471|reactome:R-HSA-381340|go:"GO:2000121"(regulation of removal of superoxide radicals)|reactome:R-HSA-434313|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6785807|reactome:R-HSA-6798695|ensembl:ENST00000447544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007596"(blood coagulation)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009897"(external side of plasma membrane)|ensembl:ENSG00000135218(gene)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015636"(short-chain fatty acid transmembrane transporter activity)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0015912"(short-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019915"(lipid storage)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030169"(low-density lipoprotein particle binding)|ensembl:ENST00000309881(transcript)|ensembl:ENST00000394788(transcript)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030666"(endocytic vesicle membrane)|ensembl:ENST00000432207(transcript)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|ensembl:ENST00000435819(transcript)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033993"(response to lipid)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070508"(cholesterol import)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070892"(lipoteichoic acid immune receptor activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0035634"(response to stilbenoid)|refseq:NP_000063.2|refseq:NP_001001547.1|refseq:NP_001001548.1|refseq:NP_001120915.1|refseq:NP_001120916.1|refseq:XP_005250770.1|refseq:XP_005250771.1|refseq:XP_005250772.1|refseq:NP_001276837.1|refseq:NP_001276838.1|refseq:NP_001276840.1	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422	-	-	-	figure legend:Supp figure 4A|comment:Results from blasting the CD36 peptide sequence used for Pull down gives 100% homology with  Human CD36, but only ~90% with the Mouse protein.|comment:A protein of approximately 60 kDa was also pulled down- and shown to be Lyn..|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2017/03/02	rogid:aYX4Uyq9gXqLN3pgTWyKWGQmL5w9606	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	rigid:PyvCTc/ZteuwrKDPKorQzn4pDFQ	false	sufficient binding region:460-472|his tag:?-?	N-phosphorylated residue:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16671	uniprotkb:P16671	intact:EBI-2808214|uniprotkb:D9IX66|uniprotkb:D9IX67|uniprotkb:D9IX68|uniprotkb:D9IX69|ensembl:ENSP00000308165|ensembl:ENSP00000378268|ensembl:ENSP00000399421|ensembl:ENSP00000411411|ensembl:ENSP00000415743|uniprotkb:Q9BQC2|uniprotkb:Q9BPZ8|uniprotkb:Q9BZN5|uniprotkb:Q9BZM8|uniprotkb:Q8TCV7|uniprotkb:Q9BZN3|uniprotkb:Q16093|uniprotkb:Q13966|uniprotkb:Q9BZN4	intact:EBI-2808214|uniprotkb:D9IX66|uniprotkb:D9IX67|uniprotkb:D9IX68|uniprotkb:D9IX69|ensembl:ENSP00000308165|ensembl:ENSP00000378268|ensembl:ENSP00000399421|ensembl:ENSP00000411411|ensembl:ENSP00000415743|uniprotkb:Q9BQC2|uniprotkb:Q9BPZ8|uniprotkb:Q9BZN5|uniprotkb:Q9BZM8|uniprotkb:Q8TCV7|uniprotkb:Q9BZN3|uniprotkb:Q16093|uniprotkb:Q13966|uniprotkb:Q9BZN4	psi-mi:cd36_human(display_long)|uniprotkb:GP3B(gene name synonym)|uniprotkb:GP4(gene name synonym)|uniprotkb:Platelet glycoprotein IV(gene name synonym)|uniprotkb:Glycoprotein IIIb(gene name synonym)|uniprotkb:Leukocyte differentiation antigen CD36(gene name synonym)|uniprotkb:PAS IV(gene name synonym)|uniprotkb:PAS-4(gene name synonym)|uniprotkb:Platelet collagen receptor(gene name synonym)|uniprotkb:Fatty acid translocase(gene name synonym)|uniprotkb:Thrombospondin receptor(gene name synonym)|uniprotkb:CD36(gene name)|psi-mi:CD36(display_short)	psi-mi:cd36_human(display_long)|uniprotkb:GP3B(gene name synonym)|uniprotkb:GP4(gene name synonym)|uniprotkb:Platelet glycoprotein IV(gene name synonym)|uniprotkb:Glycoprotein IIIb(gene name synonym)|uniprotkb:Leukocyte differentiation antigen CD36(gene name synonym)|uniprotkb:PAS IV(gene name synonym)|uniprotkb:PAS-4(gene name synonym)|uniprotkb:Platelet collagen receptor(gene name synonym)|uniprotkb:Fatty acid translocase(gene name synonym)|uniprotkb:Thrombospondin receptor(gene name synonym)|uniprotkb:CD36(gene name)|psi-mi:CD36(display_short)	psi-mi:"MI:0096"(pull down)	Stewart et al. (2010)	pubmed:20037584|imex:IM-25571	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13940953|imex:IM-25571-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:1901480"(oleate transmembrane transporter activity)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:1990379"(lipid transport across blood-brain barrier)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071944"(cell periphery)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098900"(regulation of action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150024"(oxidised low-density lipoprotein particle clearance)|go:"GO:0150025"(oxidised low-density lipoprotein particle receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|interpro:IPR002159(CD36 antigen)|interpro:IPR005428(Adhesion molecule CD36)|interpro:IPR033076|rcsb pdb:5LGD|reactome:R-HSA-114608|reactome:R-HSA-1236973|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-168188|reactome:R-HSA-1989781|reactome:R-HSA-3000471|reactome:R-HSA-381340|go:"GO:2000121"(regulation of removal of superoxide radicals)|reactome:R-HSA-434313|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6785807|reactome:R-HSA-6798695|ensembl:ENST00000447544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007596"(blood coagulation)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009897"(external side of plasma membrane)|ensembl:ENSG00000135218(gene)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015636"(short-chain fatty acid transmembrane transporter activity)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0015912"(short-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019915"(lipid storage)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030169"(low-density lipoprotein particle binding)|ensembl:ENST00000309881(transcript)|ensembl:ENST00000394788(transcript)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030666"(endocytic vesicle membrane)|ensembl:ENST00000432207(transcript)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|ensembl:ENST00000435819(transcript)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033993"(response to lipid)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070508"(cholesterol import)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070892"(lipoteichoic acid immune receptor activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0035634"(response to stilbenoid)|refseq:NP_000063.2|refseq:NP_001001547.1|refseq:NP_001001548.1|refseq:NP_001120915.1|refseq:NP_001120916.1|refseq:XP_005250770.1|refseq:XP_005250771.1|refseq:XP_005250772.1|refseq:NP_001276837.1|refseq:NP_001276838.1|refseq:NP_001276840.1	go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:1901480"(oleate transmembrane transporter activity)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:1990379"(lipid transport across blood-brain barrier)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071944"(cell periphery)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098900"(regulation of action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150024"(oxidised low-density lipoprotein particle clearance)|go:"GO:0150025"(oxidised low-density lipoprotein particle receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|interpro:IPR002159(CD36 antigen)|interpro:IPR005428(Adhesion molecule CD36)|interpro:IPR033076|rcsb pdb:5LGD|reactome:R-HSA-114608|reactome:R-HSA-1236973|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-168188|reactome:R-HSA-1989781|reactome:R-HSA-3000471|reactome:R-HSA-381340|go:"GO:2000121"(regulation of removal of superoxide radicals)|reactome:R-HSA-434313|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6785807|reactome:R-HSA-6798695|ensembl:ENST00000447544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007596"(blood coagulation)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009897"(external side of plasma membrane)|ensembl:ENSG00000135218(gene)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015636"(short-chain fatty acid transmembrane transporter activity)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0015912"(short-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019915"(lipid storage)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030169"(low-density lipoprotein particle binding)|ensembl:ENST00000309881(transcript)|ensembl:ENST00000394788(transcript)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030666"(endocytic vesicle membrane)|ensembl:ENST00000432207(transcript)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|ensembl:ENST00000435819(transcript)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033993"(response to lipid)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070508"(cholesterol import)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070892"(lipoteichoic acid immune receptor activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0035634"(response to stilbenoid)|refseq:NP_000063.2|refseq:NP_001001547.1|refseq:NP_001001548.1|refseq:NP_001120915.1|refseq:NP_001120916.1|refseq:XP_005250770.1|refseq:XP_005250771.1|refseq:XP_005250772.1|refseq:NP_001276837.1|refseq:NP_001276838.1|refseq:NP_001276840.1	-	-	-	figure legend:6C-bottom-i|comment:Results from blasting the CD36 peptide sequence used for Pull down gives 100% homology with  Human CD36, but only ~90% with the Mouse protein.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2017/03/01	rogid:aYX4Uyq9gXqLN3pgTWyKWGQmL5w9606	rogid:aYX4Uyq9gXqLN3pgTWyKWGQmL5w9606	rigid:NcWvmCspV2+UD8brLAEXFPnFSAQ	false	sufficient binding region:460-472|his tag:?-?	sufficient binding region:460-472|his tag:?-?|necessary binding region:460-463	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16671	uniprotkb:P07948	intact:EBI-2808214|uniprotkb:D9IX66|uniprotkb:D9IX67|uniprotkb:D9IX68|uniprotkb:D9IX69|ensembl:ENSP00000308165|ensembl:ENSP00000378268|ensembl:ENSP00000399421|ensembl:ENSP00000411411|ensembl:ENSP00000415743|uniprotkb:Q9BQC2|uniprotkb:Q9BPZ8|uniprotkb:Q9BZN5|uniprotkb:Q9BZM8|uniprotkb:Q8TCV7|uniprotkb:Q9BZN3|uniprotkb:Q16093|uniprotkb:Q13966|uniprotkb:Q9BZN4	intact:EBI-79452|ensembl:ENSP00000428924|uniprotkb:A0AVQ5|intact:EBI-6868890	psi-mi:cd36_human(display_long)|uniprotkb:GP3B(gene name synonym)|uniprotkb:GP4(gene name synonym)|uniprotkb:Platelet glycoprotein IV(gene name synonym)|uniprotkb:Glycoprotein IIIb(gene name synonym)|uniprotkb:Leukocyte differentiation antigen CD36(gene name synonym)|uniprotkb:PAS IV(gene name synonym)|uniprotkb:PAS-4(gene name synonym)|uniprotkb:Platelet collagen receptor(gene name synonym)|uniprotkb:Fatty acid translocase(gene name synonym)|uniprotkb:Thrombospondin receptor(gene name synonym)|uniprotkb:CD36(gene name)|psi-mi:CD36(display_short)	psi-mi:lyn_human(display_long)|uniprotkb:JTK8(gene name synonym)|uniprotkb:Lck/Yes-related novel protein tyrosine kinase(gene name synonym)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)|uniprotkb:LYN(gene name)|psi-mi:LYN(display_short)	psi-mi:"MI:0096"(pull down)	Stewart et al. (2010)	pubmed:20037584|imex:IM-25571	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13940953|imex:IM-25571-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:1901480"(oleate transmembrane transporter activity)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:1990379"(lipid transport across blood-brain barrier)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071944"(cell periphery)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098900"(regulation of action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150024"(oxidised low-density lipoprotein particle clearance)|go:"GO:0150025"(oxidised low-density lipoprotein particle receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|interpro:IPR002159(CD36 antigen)|interpro:IPR005428(Adhesion molecule CD36)|interpro:IPR033076|rcsb pdb:5LGD|reactome:R-HSA-114608|reactome:R-HSA-1236973|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-168188|reactome:R-HSA-1989781|reactome:R-HSA-3000471|reactome:R-HSA-381340|go:"GO:2000121"(regulation of removal of superoxide radicals)|reactome:R-HSA-434313|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6785807|reactome:R-HSA-6798695|ensembl:ENST00000447544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007596"(blood coagulation)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009897"(external side of plasma membrane)|ensembl:ENSG00000135218(gene)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015636"(short-chain fatty acid transmembrane transporter activity)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0015912"(short-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019915"(lipid storage)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030169"(low-density lipoprotein particle binding)|ensembl:ENST00000309881(transcript)|ensembl:ENST00000394788(transcript)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030666"(endocytic vesicle membrane)|ensembl:ENST00000432207(transcript)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|ensembl:ENST00000435819(transcript)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033993"(response to lipid)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070508"(cholesterol import)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070892"(lipoteichoic acid immune receptor activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0035634"(response to stilbenoid)|refseq:NP_000063.2|refseq:NP_001001547.1|refseq:NP_001001548.1|refseq:NP_001120915.1|refseq:NP_001120916.1|refseq:XP_005250770.1|refseq:XP_005250771.1|refseq:XP_005250772.1|refseq:NP_001276837.1|refseq:NP_001276838.1|refseq:NP_001276840.1	refseq:NP_001104567.1|refseq:NP_002341.1|ensembl:ENSG00000254087(gene)|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983695|reactome:R-HSA-9664323|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|ensembl:ENST00000519728(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032868"(response to insulin)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P07948|rcsb pdb:1W1F|rcsb pdb:1WA7|go:"GO:0099091"(postsynaptic specialization, intracellular component)|rcsb pdb:5XY1|rcsb pdb:6NMW|reactome:R-HSA-114604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2454202|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-5621480|rcsb pdb:3A4O|reactome:R-HSA-5621575|reactome:R-HSA-5690714|reactome:R-HSA-69231|reactome:R-HSA-75892|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:XP_016868905.1|dip:DIP-1056N	-	-	-	figure legend:6C-bottom-i|comment:Results from blasting the CD36 peptide sequence used for Pull down gives 100% homology with  Human CD36, but only ~90% with the Mouse protein.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2017/03/01	rogid:aYX4Uyq9gXqLN3pgTWyKWGQmL5w9606	rogid:SqXPSC+g2ZuGHy6TAPV4HcpXe6U9606	rigid:NcWvmCspV2+UD8brLAEXFPnFSAQ	false	sufficient binding region:460-472|his tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16671	uniprotkb:P07948	intact:EBI-2808214|uniprotkb:D9IX66|uniprotkb:D9IX67|uniprotkb:D9IX68|uniprotkb:D9IX69|ensembl:ENSP00000308165|ensembl:ENSP00000378268|ensembl:ENSP00000399421|ensembl:ENSP00000411411|ensembl:ENSP00000415743|uniprotkb:Q9BQC2|uniprotkb:Q9BPZ8|uniprotkb:Q9BZN5|uniprotkb:Q9BZM8|uniprotkb:Q8TCV7|uniprotkb:Q9BZN3|uniprotkb:Q16093|uniprotkb:Q13966|uniprotkb:Q9BZN4	intact:EBI-79452|ensembl:ENSP00000428924|uniprotkb:A0AVQ5|intact:EBI-6868890	psi-mi:cd36_human(display_long)|uniprotkb:GP3B(gene name synonym)|uniprotkb:GP4(gene name synonym)|uniprotkb:Platelet glycoprotein IV(gene name synonym)|uniprotkb:Glycoprotein IIIb(gene name synonym)|uniprotkb:Leukocyte differentiation antigen CD36(gene name synonym)|uniprotkb:PAS IV(gene name synonym)|uniprotkb:PAS-4(gene name synonym)|uniprotkb:Platelet collagen receptor(gene name synonym)|uniprotkb:Fatty acid translocase(gene name synonym)|uniprotkb:Thrombospondin receptor(gene name synonym)|uniprotkb:CD36(gene name)|psi-mi:CD36(display_short)	psi-mi:lyn_human(display_long)|uniprotkb:JTK8(gene name synonym)|uniprotkb:Lck/Yes-related novel protein tyrosine kinase(gene name synonym)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)|uniprotkb:LYN(gene name)|psi-mi:LYN(display_short)	psi-mi:"MI:0096"(pull down)	Stewart et al. (2010)	pubmed:20037584|imex:IM-25571	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13941132|imex:IM-25571-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:1901480"(oleate transmembrane transporter activity)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:1990379"(lipid transport across blood-brain barrier)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071944"(cell periphery)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098900"(regulation of action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150024"(oxidised low-density lipoprotein particle clearance)|go:"GO:0150025"(oxidised low-density lipoprotein particle receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|interpro:IPR002159(CD36 antigen)|interpro:IPR005428(Adhesion molecule CD36)|interpro:IPR033076|rcsb pdb:5LGD|reactome:R-HSA-114608|reactome:R-HSA-1236973|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-168188|reactome:R-HSA-1989781|reactome:R-HSA-3000471|reactome:R-HSA-381340|go:"GO:2000121"(regulation of removal of superoxide radicals)|reactome:R-HSA-434313|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6785807|reactome:R-HSA-6798695|ensembl:ENST00000447544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007596"(blood coagulation)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009897"(external side of plasma membrane)|ensembl:ENSG00000135218(gene)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015636"(short-chain fatty acid transmembrane transporter activity)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0015912"(short-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019915"(lipid storage)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030169"(low-density lipoprotein particle binding)|ensembl:ENST00000309881(transcript)|ensembl:ENST00000394788(transcript)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030666"(endocytic vesicle membrane)|ensembl:ENST00000432207(transcript)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|ensembl:ENST00000435819(transcript)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033993"(response to lipid)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070508"(cholesterol import)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070892"(lipoteichoic acid immune receptor activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0035634"(response to stilbenoid)|refseq:NP_000063.2|refseq:NP_001001547.1|refseq:NP_001001548.1|refseq:NP_001120915.1|refseq:NP_001120916.1|refseq:XP_005250770.1|refseq:XP_005250771.1|refseq:XP_005250772.1|refseq:NP_001276837.1|refseq:NP_001276838.1|refseq:NP_001276840.1	refseq:NP_001104567.1|refseq:NP_002341.1|ensembl:ENSG00000254087(gene)|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983695|reactome:R-HSA-9664323|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|ensembl:ENST00000519728(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032868"(response to insulin)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P07948|rcsb pdb:1W1F|rcsb pdb:1WA7|go:"GO:0099091"(postsynaptic specialization, intracellular component)|rcsb pdb:5XY1|rcsb pdb:6NMW|reactome:R-HSA-114604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2454202|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-5621480|rcsb pdb:3A4O|reactome:R-HSA-5621575|reactome:R-HSA-5690714|reactome:R-HSA-69231|reactome:R-HSA-75892|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:XP_016868905.1|dip:DIP-1056N	-	-	-	figure legend:Fig 6C -bottom figure|comment:Results from blasting the CD36 peptide sequence used for Pull down gives 100% homology with  Human CD36, but only ~90% with the Mouse protein.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2017/03/02	rogid:aYX4Uyq9gXqLN3pgTWyKWGQmL5w9606	rogid:SqXPSC+g2ZuGHy6TAPV4HcpXe6U9606	rigid:NcWvmCspV2+UD8brLAEXFPnFSAQ	false	sufficient binding region:460-472|his tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16671	uniprotkb:P49023	intact:EBI-2808214|uniprotkb:D9IX66|uniprotkb:D9IX67|uniprotkb:D9IX68|uniprotkb:D9IX69|ensembl:ENSP00000308165|ensembl:ENSP00000378268|ensembl:ENSP00000399421|ensembl:ENSP00000411411|ensembl:ENSP00000415743|uniprotkb:Q9BQC2|uniprotkb:Q9BPZ8|uniprotkb:Q9BZN5|uniprotkb:Q9BZM8|uniprotkb:Q8TCV7|uniprotkb:Q9BZN3|uniprotkb:Q16093|uniprotkb:Q13966|uniprotkb:Q9BZN4	intact:EBI-702209|uniprotkb:O14970|uniprotkb:O14971|uniprotkb:O60360|uniprotkb:B2RAI3|uniprotkb:Q5HYA4|uniprotkb:B7ZMB4|ensembl:ENSP00000228307	psi-mi:cd36_human(display_long)|uniprotkb:GP3B(gene name synonym)|uniprotkb:GP4(gene name synonym)|uniprotkb:Platelet glycoprotein IV(gene name synonym)|uniprotkb:Glycoprotein IIIb(gene name synonym)|uniprotkb:Leukocyte differentiation antigen CD36(gene name synonym)|uniprotkb:PAS IV(gene name synonym)|uniprotkb:PAS-4(gene name synonym)|uniprotkb:Platelet collagen receptor(gene name synonym)|uniprotkb:Fatty acid translocase(gene name synonym)|uniprotkb:Thrombospondin receptor(gene name synonym)|uniprotkb:CD36(gene name)|psi-mi:CD36(display_short)	psi-mi:paxi_human(display_long)|uniprotkb:PXN(gene name)|psi-mi:PXN(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Stewart et al. (2010)	pubmed:20037584|imex:IM-25571	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13941228|imex:IM-25571-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:1901480"(oleate transmembrane transporter activity)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:1990379"(lipid transport across blood-brain barrier)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071944"(cell periphery)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098900"(regulation of action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150024"(oxidised low-density lipoprotein particle clearance)|go:"GO:0150025"(oxidised low-density lipoprotein particle receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|interpro:IPR002159(CD36 antigen)|interpro:IPR005428(Adhesion molecule CD36)|interpro:IPR033076|rcsb pdb:5LGD|reactome:R-HSA-114608|reactome:R-HSA-1236973|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-168188|reactome:R-HSA-1989781|reactome:R-HSA-3000471|reactome:R-HSA-381340|go:"GO:2000121"(regulation of removal of superoxide radicals)|reactome:R-HSA-434313|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6785807|reactome:R-HSA-6798695|ensembl:ENST00000447544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007596"(blood coagulation)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009897"(external side of plasma membrane)|ensembl:ENSG00000135218(gene)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015636"(short-chain fatty acid transmembrane transporter activity)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0015912"(short-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019915"(lipid storage)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030169"(low-density lipoprotein particle binding)|ensembl:ENST00000309881(transcript)|ensembl:ENST00000394788(transcript)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030666"(endocytic vesicle membrane)|ensembl:ENST00000432207(transcript)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|ensembl:ENST00000435819(transcript)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033993"(response to lipid)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070508"(cholesterol import)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070892"(lipoteichoic acid immune receptor activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0035634"(response to stilbenoid)|refseq:NP_000063.2|refseq:NP_001001547.1|refseq:NP_001001548.1|refseq:NP_001120915.1|refseq:NP_001120916.1|refseq:XP_005250770.1|refseq:XP_005250771.1|refseq:XP_005250772.1|refseq:NP_001276837.1|refseq:NP_001276838.1|refseq:NP_001276840.1	refseq:NP_001074324.1|refseq:NP_002850.2|refseq:NP_079433.3|refseq:NP_001230685.1|refseq:XP_016875232.1|dip:DIP-33851N|ensembl:ENSG00000089159(gene)|ensembl:ENST00000228307(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0017166"(vinculin binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0038191"(neuropilin binding)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR001904(Paxillin)|mint:P49023|rcsb pdb:1KKY|rcsb pdb:1KL0|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2K2R|rcsb pdb:2O9V|rcsb pdb:2VZD|rcsb pdb:2VZG|rcsb pdb:2VZI|rcsb pdb:3GM1|rcsb pdb:3PY7|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3U3F|rcsb pdb:4EDN|rcsb pdb:4R32|rcsb pdb:4XGZ|rcsb pdb:4XH2|rcsb pdb:5UWH|rcsb pdb:6IUI|rcsb pdb:6PW8|rcsb pdb:6U4M|rcsb pdb:6U4N|reactome:R-HSA-180292|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-446343|reactome:R-HSA-446388|reactome:R-HSA-8849471	-	-	-	figure legend:Supp figure 4Bi|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-c32)|taxid:9606("C32 melanoma cell line, amelanotic (colourless)")	-	2017/02/16	2017/03/02	rogid:aYX4Uyq9gXqLN3pgTWyKWGQmL5w9606	rogid:H8osAQRrVydLfDL97uSSA6Mf6ME9606	rigid:ltV5COC055CjaOGsxtkGxEFCTbk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16671	uniprotkb:P07948	intact:EBI-2808214|uniprotkb:D9IX66|uniprotkb:D9IX67|uniprotkb:D9IX68|uniprotkb:D9IX69|ensembl:ENSP00000308165|ensembl:ENSP00000378268|ensembl:ENSP00000399421|ensembl:ENSP00000411411|ensembl:ENSP00000415743|uniprotkb:Q9BQC2|uniprotkb:Q9BPZ8|uniprotkb:Q9BZN5|uniprotkb:Q9BZM8|uniprotkb:Q8TCV7|uniprotkb:Q9BZN3|uniprotkb:Q16093|uniprotkb:Q13966|uniprotkb:Q9BZN4	intact:EBI-79452|ensembl:ENSP00000428924|uniprotkb:A0AVQ5|intact:EBI-6868890	psi-mi:cd36_human(display_long)|uniprotkb:GP3B(gene name synonym)|uniprotkb:GP4(gene name synonym)|uniprotkb:Platelet glycoprotein IV(gene name synonym)|uniprotkb:Glycoprotein IIIb(gene name synonym)|uniprotkb:Leukocyte differentiation antigen CD36(gene name synonym)|uniprotkb:PAS IV(gene name synonym)|uniprotkb:PAS-4(gene name synonym)|uniprotkb:Platelet collagen receptor(gene name synonym)|uniprotkb:Fatty acid translocase(gene name synonym)|uniprotkb:Thrombospondin receptor(gene name synonym)|uniprotkb:CD36(gene name)|psi-mi:CD36(display_short)	psi-mi:lyn_human(display_long)|uniprotkb:JTK8(gene name synonym)|uniprotkb:Lck/Yes-related novel protein tyrosine kinase(gene name synonym)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)|uniprotkb:LYN(gene name)|psi-mi:LYN(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Stewart et al. (2010)	pubmed:20037584|imex:IM-25571	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13941228|imex:IM-25571-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:1901480"(oleate transmembrane transporter activity)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:1990379"(lipid transport across blood-brain barrier)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071944"(cell periphery)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098900"(regulation of action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150024"(oxidised low-density lipoprotein particle clearance)|go:"GO:0150025"(oxidised low-density lipoprotein particle receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|interpro:IPR002159(CD36 antigen)|interpro:IPR005428(Adhesion molecule CD36)|interpro:IPR033076|rcsb pdb:5LGD|reactome:R-HSA-114608|reactome:R-HSA-1236973|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-168188|reactome:R-HSA-1989781|reactome:R-HSA-3000471|reactome:R-HSA-381340|go:"GO:2000121"(regulation of removal of superoxide radicals)|reactome:R-HSA-434313|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6785807|reactome:R-HSA-6798695|ensembl:ENST00000447544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007596"(blood coagulation)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009897"(external side of plasma membrane)|ensembl:ENSG00000135218(gene)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015636"(short-chain fatty acid transmembrane transporter activity)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0015912"(short-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019915"(lipid storage)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030169"(low-density lipoprotein particle binding)|ensembl:ENST00000309881(transcript)|ensembl:ENST00000394788(transcript)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030666"(endocytic vesicle membrane)|ensembl:ENST00000432207(transcript)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|ensembl:ENST00000435819(transcript)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033993"(response to lipid)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070508"(cholesterol import)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070892"(lipoteichoic acid immune receptor activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0035634"(response to stilbenoid)|refseq:NP_000063.2|refseq:NP_001001547.1|refseq:NP_001001548.1|refseq:NP_001120915.1|refseq:NP_001120916.1|refseq:XP_005250770.1|refseq:XP_005250771.1|refseq:XP_005250772.1|refseq:NP_001276837.1|refseq:NP_001276838.1|refseq:NP_001276840.1	refseq:NP_001104567.1|refseq:NP_002341.1|ensembl:ENSG00000254087(gene)|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983695|reactome:R-HSA-9664323|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|ensembl:ENST00000519728(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032868"(response to insulin)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P07948|rcsb pdb:1W1F|rcsb pdb:1WA7|go:"GO:0099091"(postsynaptic specialization, intracellular component)|rcsb pdb:5XY1|rcsb pdb:6NMW|reactome:R-HSA-114604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2454202|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-5621480|rcsb pdb:3A4O|reactome:R-HSA-5621575|reactome:R-HSA-5690714|reactome:R-HSA-69231|reactome:R-HSA-75892|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:XP_016868905.1|dip:DIP-1056N	-	-	-	figure legend:Supp figure 4Bi|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-c32)|taxid:9606("C32 melanoma cell line, amelanotic (colourless)")	-	2017/02/16	2017/03/02	rogid:aYX4Uyq9gXqLN3pgTWyKWGQmL5w9606	rogid:SqXPSC+g2ZuGHy6TAPV4HcpXe6U9606	rigid:ltV5COC055CjaOGsxtkGxEFCTbk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)