#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B intact:EBI-15822083 uniprotkb:Q16832 dip:DIP-48349N intact:EBI-1381484|uniprotkb:Q7Z730|ensembl:ENSP00000356898|ensembl:ENSP00000356899|ensembl:ENSP00000400309 psi-mi:collagenpeptide3(display_short)|psi-mi:EBI-15822083(display_long) psi-mi:ddr2_human(display_long)|uniprotkb:Discoidin domain-containing receptor tyrosine kinase 2(gene name synonym)|uniprotkb:DDR2(gene name)|psi-mi:DDR2(display_short)|uniprotkb:NTRKR3(gene name synonym)|uniprotkb:TKT(gene name synonym)|uniprotkb:TYRO10(gene name synonym)|uniprotkb:Receptor protein-tyrosine kinase TKT(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO10(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase, receptor-related 3(gene name synonym)|uniprotkb:CD167 antigen-like family member B(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Carafoli et al. (2009) pubmed:20004161|doi:10.1016/j.str.2009.10.012|imex:IM-13617 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15822088|imex:IM-13617-1|dip:DIP-102599E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:XP_006711407.1|refseq:NP_001014796.1|refseq:NP_006173.2|refseq:XP_011507889.1|refseq:XP_011507888.1|dip:DIP-39699N|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020635|interpro:IPR034299|mint:Q16832|rcsb pdb:2WUH|rcsb pdb:2Z4F|rcsb pdb:6FER|rcsb pdb:7AZB|reactome:R-HSA-3000171|ensembl:ENSG00000162733(gene)|ensembl:ENST00000367921(transcript)|ensembl:ENST00000367922(transcript)|ensembl:ENST00000446985(transcript)|go:"GO:0001503"(ossification)|go:"GO:0003416"(endochondral bone growth)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010715"(regulation of extracellular matrix disassembly)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0038062"(protein tyrosine kinase collagen receptor activity)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:lPZkjp7uUIj3dCO4v5++fIzBe7E-2 rogid:aWup/fmqKPNU6Zg5aMeU8wKGUPU9606 rigid:EZQ73ISA4B8eyI3HVrL8i5gbzt4 false 4-hydroxy-L-proline:9-9,6-6,3-3,27-27,24-24,21-21,15-15|protein modification:18-18 binding-associated region:26-190 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-15822117 uniprotkb:Q16832 dip:DIP-48350N intact:EBI-1381484|uniprotkb:Q7Z730|ensembl:ENSP00000356898|ensembl:ENSP00000356899|ensembl:ENSP00000400309 psi-mi:collagenpeptide5(display_short)|psi-mi:EBI-15822117(display_long) psi-mi:ddr2_human(display_long)|uniprotkb:Discoidin domain-containing receptor tyrosine kinase 2(gene name synonym)|uniprotkb:DDR2(gene name)|psi-mi:DDR2(display_short)|uniprotkb:NTRKR3(gene name synonym)|uniprotkb:TKT(gene name synonym)|uniprotkb:TYRO10(gene name synonym)|uniprotkb:Receptor protein-tyrosine kinase TKT(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO10(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase, receptor-related 3(gene name synonym)|uniprotkb:CD167 antigen-like family member B(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Carafoli et al. (2009) pubmed:20004161|doi:10.1016/j.str.2009.10.012|imex:IM-13617 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15822120|imex:IM-13617-2|dip:DIP-102600E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:XP_006711407.1|refseq:NP_001014796.1|refseq:NP_006173.2|refseq:XP_011507889.1|refseq:XP_011507888.1|dip:DIP-39699N|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020635|interpro:IPR034299|mint:Q16832|rcsb pdb:2WUH|rcsb pdb:2Z4F|rcsb pdb:6FER|rcsb pdb:7AZB|reactome:R-HSA-3000171|ensembl:ENSG00000162733(gene)|ensembl:ENST00000367921(transcript)|ensembl:ENST00000367922(transcript)|ensembl:ENST00000446985(transcript)|go:"GO:0001503"(ossification)|go:"GO:0003416"(endochondral bone growth)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010715"(regulation of extracellular matrix disassembly)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0038062"(protein tyrosine kinase collagen receptor activity)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:VgXVlz+OHBc9hVmEKVUkBizWE4U-2 rogid:aWup/fmqKPNU6Zg5aMeU8wKGUPU9606 rigid:7Th1kiNCaF1N/mFEOCB8QwwVrK0 false 4-hydroxy-L-proline:30-30,24-24 binding-associated region:22-398 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-15822083 uniprotkb:Q16832 dip:DIP-48349N intact:EBI-1381484|uniprotkb:Q7Z730|ensembl:ENSP00000356898|ensembl:ENSP00000356899|ensembl:ENSP00000400309 psi-mi:collagenpeptide3(display_short)|psi-mi:EBI-15822083(display_long) psi-mi:ddr2_human(display_long)|uniprotkb:Discoidin domain-containing receptor tyrosine kinase 2(gene name synonym)|uniprotkb:DDR2(gene name)|psi-mi:DDR2(display_short)|uniprotkb:NTRKR3(gene name synonym)|uniprotkb:TKT(gene name synonym)|uniprotkb:TYRO10(gene name synonym)|uniprotkb:Receptor protein-tyrosine kinase TKT(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO10(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase, receptor-related 3(gene name synonym)|uniprotkb:CD167 antigen-like family member B(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Carafoli et al. (2009) pubmed:20004161|doi:10.1016/j.str.2009.10.012|imex:IM-13617 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15822143|imex:IM-13617-3|dip:DIP-102599E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:XP_006711407.1|refseq:NP_001014796.1|refseq:NP_006173.2|refseq:XP_011507889.1|refseq:XP_011507888.1|dip:DIP-39699N|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020635|interpro:IPR034299|mint:Q16832|rcsb pdb:2WUH|rcsb pdb:2Z4F|rcsb pdb:6FER|rcsb pdb:7AZB|reactome:R-HSA-3000171|ensembl:ENSG00000162733(gene)|ensembl:ENST00000367921(transcript)|ensembl:ENST00000367922(transcript)|ensembl:ENST00000446985(transcript)|go:"GO:0001503"(ossification)|go:"GO:0003416"(endochondral bone growth)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010715"(regulation of extracellular matrix disassembly)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0038062"(protein tyrosine kinase collagen receptor activity)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:lPZkjp7uUIj3dCO4v5++fIzBe7E-2 rogid:aWup/fmqKPNU6Zg5aMeU8wKGUPU9606 rigid:EZQ73ISA4B8eyI3HVrL8i5gbzt4 false 4-hydroxy-L-proline:9-9,6-6,3-3,27-27,24-24,21-21,15-15|protein modification:18-18 binding-associated region:26-190 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)