#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q6TEQ7	uniprotkb:P56402	intact:EBI-7008850|ensembl:ENSCAFP00030015356|intact:MINT-3375172	intact:EBI-15821118|ensembl:ENSMUSP00000023752|uniprotkb:Q8VCG5|uniprotkb:Q9R232	psi-mi:anxa2_canlf(display_long)|uniprotkb:ANX2(gene name synonym)|uniprotkb:ANXA2(gene name)|psi-mi:ANXA2(display_short)|uniprotkb:Annexin-2(gene name synonym)	psi-mi:aqp2_mouse(display_long)|uniprotkb:Aqp2(gene name)|psi-mi:Aqp2(display_short)|uniprotkb:ADH water channel(gene name synonym)|uniprotkb:Aquaporin-CD(gene name synonym)|uniprotkb:Collecting duct water channel protein(gene name synonym)|uniprotkb:WCH-CD(gene name synonym)|uniprotkb:Water channel protein for renal collecting duct(gene name synonym)|uniprotkb:cph(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Moeller et al. (2010)	pubmed:19966308|doi:10.1073/pnas.0910683107|imex:IM-14916	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15821165|imex:IM-14916-1|dip:DIP-185481E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSCAFG00030009412(gene)|ensembl:ENSCAFT00030017582(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002020"(protease binding)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0031982"(vesicle)|go:"GO:0046790"(virion binding)|go:"GO:0070382"(exocytic vesicle)|interpro:IPR001464(Annexin)|interpro:IPR002389(Annexin, type II)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:Q6TEQ7|reactome:R-CFA-6798695|refseq:NP_001002961.1|dip:DIP-44616N	ensembl:ENSMUSG00000023013(gene)|ensembl:ENSMUST00000023752(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015793"(glycerol transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030133"(transport vesicle)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031303"(integral component of endosome membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042631"(cellular response to water deprivation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0098576"(lumenal side of membrane)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR034294|reactome:R-MMU-432040|reactome:R-MMU-432047|refseq:NP_033829.3|dip:DIP-58509N	psi-mi:"MI:0465"(dip)	function:Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	-	2017/08/06	2017/08/10	rogid:ytTAmuAuytDkTUoMfe5aUezdd049615	rogid:Vva1TsrlARkd00dYweQAwJ7Ucoo10090	rigid:hagRus9J/Ey19Gsj77vfYEBSMvQ	false	-	mutation increasing interaction:256-256	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7YQC6	uniprotkb:P56402	intact:EBI-7008712|uniprotkb:Q8WNS9|intact:MINT-3374994	intact:EBI-15821118|ensembl:ENSMUSP00000023752|uniprotkb:Q8VCG5|uniprotkb:Q9R232	psi-mi:hsp71_canlf(display_long)|uniprotkb:HSPA1(gene name)|psi-mi:HSPA1(display_short)|uniprotkb:Hsp70(gene name synonym)	psi-mi:aqp2_mouse(display_long)|uniprotkb:Aqp2(gene name)|psi-mi:Aqp2(display_short)|uniprotkb:ADH water channel(gene name synonym)|uniprotkb:Aquaporin-CD(gene name synonym)|uniprotkb:Collecting duct water channel protein(gene name synonym)|uniprotkb:WCH-CD(gene name synonym)|uniprotkb:Water channel protein for renal collecting duct(gene name synonym)|uniprotkb:cph(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Moeller et al. (2010)	pubmed:19966308|doi:10.1073/pnas.0910683107|imex:IM-14916	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15821185|imex:IM-14916-2|dip:DIP-185482E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005813"(centrosome)|refseq:NP_001003067.2|mint:Q7YQC6|dip:DIP-44612N	ensembl:ENSMUSG00000023013(gene)|ensembl:ENSMUST00000023752(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015793"(glycerol transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030133"(transport vesicle)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031303"(integral component of endosome membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042631"(cellular response to water deprivation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0098576"(lumenal side of membrane)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR034294|reactome:R-MMU-432040|reactome:R-MMU-432047|refseq:NP_033829.3|dip:DIP-58509N	psi-mi:"MI:0465"(dip)	comment:mint|function:In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	-	2017/08/06	2017/08/10	rogid:SC2qYD3/UU6J/xkNVva06CmiuQ09615	rogid:Vva1TsrlARkd00dYweQAwJ7Ucoo10090	rigid:e4PumCmEvHhgiL2QOp6Z45tyrro	false	-	mutation decreasing interaction:269-269	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)