#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O35082 uniprotkb:P11362 intact:EBI-1570828|uniprotkb:O70175|uniprotkb:O70621|uniprotkb:B2RR78|ensembl:ENSMUSP00000077899 intact:EBI-1028277|uniprotkb:P17049|uniprotkb:Q02063|uniprotkb:Q02065|uniprotkb:Q14306|uniprotkb:Q14307|uniprotkb:Q8N685|uniprotkb:C1KBH8|uniprotkb:Q9UDF0|uniprotkb:Q9UDF1|uniprotkb:Q9UDF2|uniprotkb:Q59H40|uniprotkb:Q5BJG2|uniprotkb:A8K6T9|uniprotkb:A8K8V5|uniprotkb:Q53H63|uniprotkb:Q9UD50|intact:EBI-1058611|ensembl:ENSP00000400162 psi-mi:klot_mouse(display_long)|uniprotkb:Kl(gene name)|psi-mi:Kl(display_short) psi-mi:fgfr1_human(display_long)|uniprotkb:FGFR1(gene name)|psi-mi:FGFR1(display_short)|uniprotkb:FGFBR(gene name synonym)|uniprotkb:FLG(gene name synonym)|uniprotkb:FLT2(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 2(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:BFGFR(gene name synonym)|uniprotkb:CEK(gene name synonym)|uniprotkb:HBGFR(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:N-sam(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Goetz et al. (2010) pubmed:19966287|doi:10.1073/pnas.0902006107|imex:IM-14912 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15820492|imex:IM-14912-1|dip:DIP-185465E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038851.2|dip:DIP-39894N|ensembl:ENSMUSG00000058488(gene)|ensembl:ENSMUST00000078856(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0004566"(beta-glucuronidase activity)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008422"(beta-glucosidase activity)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028546|interpro:IPR033132|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190374|reactome:R-MMU-5654219|reactome:R-MMU-5654687|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654726|reactome:R-MMU-5673001|reactome:R-MMU-6811558 refseq:NP_001167534.1|refseq:NP_001167535.1|refseq:NP_001167536.1|refseq:NP_001167537.1|refseq:NP_001167538.1|refseq:NP_056934.2|refseq:NP_075593.1|refseq:NP_075594.1|refseq:NP_075598.2|ensembl:ENSG00000077782(gene)|ensembl:ENST00000447712(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001501"(skeletal system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2001239"(regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR028174|interpro:IPR036179|interpro:IPR041159|mint:P11362|rcsb pdb:1AGW|rcsb pdb:1CVS|rcsb pdb:1EVT|rcsb pdb:1FGI|rcsb pdb:1FGK|rcsb pdb:1FQ9|go:"GO:0045666"(positive regulation of neuron differentiation)|rcsb pdb:1XR0|rcsb pdb:2CR3|rcsb pdb:2FGI|rcsb pdb:3C4F|rcsb pdb:3DPK|rcsb pdb:3GQI|rcsb pdb:3GQL|rcsb pdb:3JS2|rcsb pdb:3KRJ|rcsb pdb:3KRL|rcsb pdb:3KXX|rcsb pdb:3KY2|rcsb pdb:3OJV|rcsb pdb:3RHX|rcsb pdb:3TT0|rcsb pdb:4F63|rcsb pdb:4F64|rcsb pdb:4F65|rcsb pdb:4NK9|rcsb pdb:4NKA|rcsb pdb:4NKS|rcsb pdb:4RWI|rcsb pdb:4RWJ|rcsb pdb:4RWK|rcsb pdb:4RWL|rcsb pdb:4UWC|rcsb pdb:4UWY|rcsb pdb:4V01|rcsb pdb:4V04|rcsb pdb:4V05|rcsb pdb:4WUN|rcsb pdb:4ZSA|rcsb pdb:5A46|rcsb pdb:5A4C|rcsb pdb:5AM6|rcsb pdb:5AM7|rcsb pdb:5B7V|rcsb pdb:5EW8|rcsb pdb:5FLF|rcsb pdb:5O49|rcsb pdb:5O4A|rcsb pdb:5UQ0|rcsb pdb:5UR1|rcsb pdb:5VND|rcsb pdb:5W21|rcsb pdb:5W59|rcsb pdb:5Z0S|rcsb pdb:5ZV2|rcsb pdb:6C18|rcsb pdb:6C19|rcsb pdb:6C1B|rcsb pdb:6C1C|rcsb pdb:6C1O|rcsb pdb:6ITJ|rcsb pdb:6MZQ|rcsb pdb:6MZW|rcsb pdb:6NVL|rcsb pdb:6P68|rcsb pdb:6P69|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839120|rcsb pdb:4UWB|reactome:R-HSA-1839122|reactome:R-HSA-190370|reactome:R-HSA-190373|reactome:R-HSA-190374|reactome:R-HSA-2219530|reactome:R-HSA-375165|reactome:R-HSA-445144|reactome:R-HSA-5654219|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853336|reactome:R-HSA-5654726|dip:DIP-4019N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:rj/Wc7xYgFTXmP6J9nzgH5rJuhc10090 rogid:th/BEfNYh60oKK7G0HFX+O1pXh89606 rigid:PfMDEbvDrCXrHlpkoXSVXi8zjP0 false binding-associated region:35-982 binding-associated region:142-365 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O35082 uniprotkb:P11362 intact:EBI-1570828|uniprotkb:O70175|uniprotkb:O70621|uniprotkb:B2RR78|ensembl:ENSMUSP00000077899 intact:EBI-1028277|uniprotkb:P17049|uniprotkb:Q02063|uniprotkb:Q02065|uniprotkb:Q14306|uniprotkb:Q14307|uniprotkb:Q8N685|uniprotkb:C1KBH8|uniprotkb:Q9UDF0|uniprotkb:Q9UDF1|uniprotkb:Q9UDF2|uniprotkb:Q59H40|uniprotkb:Q5BJG2|uniprotkb:A8K6T9|uniprotkb:A8K8V5|uniprotkb:Q53H63|uniprotkb:Q9UD50|intact:EBI-1058611|ensembl:ENSP00000400162 psi-mi:klot_mouse(display_long)|uniprotkb:Kl(gene name)|psi-mi:Kl(display_short) psi-mi:fgfr1_human(display_long)|uniprotkb:FGFR1(gene name)|psi-mi:FGFR1(display_short)|uniprotkb:FGFBR(gene name synonym)|uniprotkb:FLG(gene name synonym)|uniprotkb:FLT2(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 2(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:BFGFR(gene name synonym)|uniprotkb:CEK(gene name synonym)|uniprotkb:HBGFR(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:N-sam(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Goetz et al. (2010) pubmed:19966287|doi:10.1073/pnas.0902006107|imex:IM-14912 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15820569|imex:IM-14912-4|dip:DIP-185465E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038851.2|dip:DIP-39894N|ensembl:ENSMUSG00000058488(gene)|ensembl:ENSMUST00000078856(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0004566"(beta-glucuronidase activity)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008422"(beta-glucosidase activity)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028546|interpro:IPR033132|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190374|reactome:R-MMU-5654219|reactome:R-MMU-5654687|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654726|reactome:R-MMU-5673001|reactome:R-MMU-6811558 refseq:NP_001167534.1|refseq:NP_001167535.1|refseq:NP_001167536.1|refseq:NP_001167537.1|refseq:NP_001167538.1|refseq:NP_056934.2|refseq:NP_075593.1|refseq:NP_075594.1|refseq:NP_075598.2|ensembl:ENSG00000077782(gene)|ensembl:ENST00000447712(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001501"(skeletal system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2001239"(regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR028174|interpro:IPR036179|interpro:IPR041159|mint:P11362|rcsb pdb:1AGW|rcsb pdb:1CVS|rcsb pdb:1EVT|rcsb pdb:1FGI|rcsb pdb:1FGK|rcsb pdb:1FQ9|go:"GO:0045666"(positive regulation of neuron differentiation)|rcsb pdb:1XR0|rcsb pdb:2CR3|rcsb pdb:2FGI|rcsb pdb:3C4F|rcsb pdb:3DPK|rcsb pdb:3GQI|rcsb pdb:3GQL|rcsb pdb:3JS2|rcsb pdb:3KRJ|rcsb pdb:3KRL|rcsb pdb:3KXX|rcsb pdb:3KY2|rcsb pdb:3OJV|rcsb pdb:3RHX|rcsb pdb:3TT0|rcsb pdb:4F63|rcsb pdb:4F64|rcsb pdb:4F65|rcsb pdb:4NK9|rcsb pdb:4NKA|rcsb pdb:4NKS|rcsb pdb:4RWI|rcsb pdb:4RWJ|rcsb pdb:4RWK|rcsb pdb:4RWL|rcsb pdb:4UWC|rcsb pdb:4UWY|rcsb pdb:4V01|rcsb pdb:4V04|rcsb pdb:4V05|rcsb pdb:4WUN|rcsb pdb:4ZSA|rcsb pdb:5A46|rcsb pdb:5A4C|rcsb pdb:5AM6|rcsb pdb:5AM7|rcsb pdb:5B7V|rcsb pdb:5EW8|rcsb pdb:5FLF|rcsb pdb:5O49|rcsb pdb:5O4A|rcsb pdb:5UQ0|rcsb pdb:5UR1|rcsb pdb:5VND|rcsb pdb:5W21|rcsb pdb:5W59|rcsb pdb:5Z0S|rcsb pdb:5ZV2|rcsb pdb:6C18|rcsb pdb:6C19|rcsb pdb:6C1B|rcsb pdb:6C1C|rcsb pdb:6C1O|rcsb pdb:6ITJ|rcsb pdb:6MZQ|rcsb pdb:6MZW|rcsb pdb:6NVL|rcsb pdb:6P68|rcsb pdb:6P69|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839120|rcsb pdb:4UWB|reactome:R-HSA-1839122|reactome:R-HSA-190370|reactome:R-HSA-190373|reactome:R-HSA-190374|reactome:R-HSA-2219530|reactome:R-HSA-375165|reactome:R-HSA-445144|reactome:R-HSA-5654219|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853336|reactome:R-HSA-5654726|dip:DIP-4019N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:rj/Wc7xYgFTXmP6J9nzgH5rJuhc10090 rogid:th/BEfNYh60oKK7G0HFX+O1pXh89606 rigid:PfMDEbvDrCXrHlpkoXSVXi8zjP0 false binding-associated region:35-982 binding-associated region:142-365 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:O35082 uniprotkb:Q61851-1 intact:EBI-1570828|uniprotkb:O70175|uniprotkb:O70621|uniprotkb:B2RR78|ensembl:ENSMUSP00000077899 intact:EBI-15820536 psi-mi:klot_mouse(display_long)|uniprotkb:Kl(gene name)|psi-mi:Kl(display_short) psi-mi:q61851-1(display_long)|uniprotkb:Fgfr3(gene name)|psi-mi:Fgfr3(display_short)|uniprotkb:Mfr3(gene name synonym)|uniprotkb:Sam3(gene name synonym)|uniprotkb:IIIc(isoform synonym)|uniprotkb:Heparin-binding growth factor receptor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goetz et al. (2010) pubmed:19966287|doi:10.1073/pnas.0902006107|imex:IM-14912 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15820545|imex:IM-14912-3|dip:DIP-185467E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038851.2|dip:DIP-39894N|ensembl:ENSMUSG00000058488(gene)|ensembl:ENSMUST00000078856(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0004566"(beta-glucuronidase activity)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008422"(beta-glucosidase activity)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028546|interpro:IPR033132|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190374|reactome:R-MMU-5654219|reactome:R-MMU-5654687|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654726|reactome:R-MMU-5673001|reactome:R-MMU-6811558 intact:EBI-6287052(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:rj/Wc7xYgFTXmP6J9nzgH5rJuhc10090 rogid:3jdly+HWh0GwI6obkw98fhYrj0k10090 rigid:BupYzn0FKFV23PvDFO8B4eM456Q false flag tag:c-c|binding-associated region:35-982 v5 tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P16092 uniprotkb:O35082 intact:EBI-7953898|uniprotkb:Q60830|uniprotkb:Q01736|uniprotkb:Q8CFK8|intact:MINT-2635590|uniprotkb:Q80T10|uniprotkb:E9Q2P4|uniprotkb:Q61562|uniprotkb:Q9QZM7|ensembl:ENSMUSP00000081041 intact:EBI-1570828|uniprotkb:O70175|uniprotkb:O70621|uniprotkb:B2RR78|ensembl:ENSMUSP00000077899 psi-mi:fgfr1_mouse(display_long)|uniprotkb:Fgfr1(gene name)|psi-mi:Fgfr1(display_short)|uniprotkb:Flg(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:MFR(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym) psi-mi:klot_mouse(display_long)|uniprotkb:Kl(gene name)|psi-mi:Kl(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goetz et al. (2010) pubmed:19966287|doi:10.1073/pnas.0902006107|imex:IM-14912 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15820513|imex:IM-14912-2|dip:DIP-185472E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011240423.1|refseq:NP_034336.2|refseq:NP_001073378.1|refseq:NP_001073377.1|refseq:XP_006509073.1|refseq:XP_006509075.1|dip:DIP-6033N|ensembl:ENSMUSG00000031565(gene)|ensembl:ENSMUST00000084027(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001759"(organ induction)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0021837"(motogenic signaling involved in postnatal olfactory bulb interneuron migration)|go:"GO:0021847"(ventricular zone neuroblast division)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030901"(midbrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035607"(fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043583"(ear development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR028174|interpro:IPR036179|interpro:IPR041159|mint:P16092|rcsb pdb:2CKN|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190370|reactome:R-MMU-190373|reactome:R-MMU-190374|reactome:R-MMU-445144|reactome:R-MMU-5654219|reactome:R-MMU-5654687|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654726|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048699"(generation of neurons)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051174"(regulation of phosphorus metabolic process)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060117"(auditory receptor cell development)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060665"(regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0070640"(vitamin D3 metabolic process)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:0090272"(negative regulation of fibroblast growth factor production)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1903465"(positive regulation of mitotic cell cycle DNA replication)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000830"(positive regulation of parathyroid hormone secretion)|go:"GO:2001239"(regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor) refseq:NP_038851.2|dip:DIP-39894N|ensembl:ENSMUSG00000058488(gene)|ensembl:ENSMUST00000078856(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0004566"(beta-glucuronidase activity)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008422"(beta-glucosidase activity)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028546|interpro:IPR033132|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190374|reactome:R-MMU-5654219|reactome:R-MMU-5654687|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654726|reactome:R-MMU-5673001|reactome:R-MMU-6811558 psi-mi:"MI:0465"(dip) comment:mint|function:"Receptor for basic fibroblast growth factor. A shorter form of the receptor could be a receptor for FGF1 (aFGF)"|comment:homomint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:JSLRQxD7C6jJyldtTkRE1Zn+AvE10090 rogid:rj/Wc7xYgFTXmP6J9nzgH5rJuhc10090 rigid:7pkgPKPjHdC8MUQwbAe8vtfpx8Y false v5 tag:c-c flag tag:c-c|binding-associated region:35-982 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9GZV9 uniprotkb:P11362 intact:EBI-6594125|ensembl:ENSP00000237837|uniprotkb:Q4V758 intact:EBI-1028277|uniprotkb:P17049|uniprotkb:Q02063|uniprotkb:Q02065|uniprotkb:Q14306|uniprotkb:Q14307|uniprotkb:Q8N685|uniprotkb:C1KBH8|uniprotkb:Q9UDF0|uniprotkb:Q9UDF1|uniprotkb:Q9UDF2|uniprotkb:Q59H40|uniprotkb:Q5BJG2|uniprotkb:A8K6T9|uniprotkb:A8K8V5|uniprotkb:Q53H63|uniprotkb:Q9UD50|intact:EBI-1058611|ensembl:ENSP00000400162 psi-mi:fgf23_human(display_long)|uniprotkb:FGF23(gene name)|psi-mi:FGF23(display_short)|uniprotkb:HYPF(gene name synonym)|uniprotkb:Phosphatonin(gene name synonym)|uniprotkb:Tumor-derived hypophosphatemia-inducing factor(gene name synonym)|uniprotkb:UNQ3027/PRO9828(orf name) psi-mi:fgfr1_human(display_long)|uniprotkb:FGFR1(gene name)|psi-mi:FGFR1(display_short)|uniprotkb:FGFBR(gene name synonym)|uniprotkb:FLG(gene name synonym)|uniprotkb:FLT2(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 2(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:BFGFR(gene name synonym)|uniprotkb:CEK(gene name synonym)|uniprotkb:HBGFR(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:N-sam(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Goetz et al. (2010) pubmed:19966287|doi:10.1073/pnas.0902006107|imex:IM-14912 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15820590|imex:IM-14912-5|dip:DIP-185469E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000118972(gene)|ensembl:ENST00000237837(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005105"(type 1 fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0010980"(positive regulation of vitamin D 24-hydroxylase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0042369"(vitamin D catabolic process)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:1904383"(response to sodium phosphate)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028304|rcsb pdb:2P39|rcsb pdb:5W21|rcsb pdb:6S22|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190322|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190374|reactome:R-HSA-190375|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-381426|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853338|reactome:R-HSA-8957275|refseq:NP_065689.1|dip:DIP-58507N refseq:NP_001167534.1|refseq:NP_001167535.1|refseq:NP_001167536.1|refseq:NP_001167537.1|refseq:NP_001167538.1|refseq:NP_056934.2|refseq:NP_075593.1|refseq:NP_075594.1|refseq:NP_075598.2|ensembl:ENSG00000077782(gene)|ensembl:ENST00000447712(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001501"(skeletal system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2001239"(regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR028174|interpro:IPR036179|interpro:IPR041159|mint:P11362|rcsb pdb:1AGW|rcsb pdb:1CVS|rcsb pdb:1EVT|rcsb pdb:1FGI|rcsb pdb:1FGK|rcsb pdb:1FQ9|go:"GO:0045666"(positive regulation of neuron differentiation)|rcsb pdb:1XR0|rcsb pdb:2CR3|rcsb pdb:2FGI|rcsb pdb:3C4F|rcsb pdb:3DPK|rcsb pdb:3GQI|rcsb pdb:3GQL|rcsb pdb:3JS2|rcsb pdb:3KRJ|rcsb pdb:3KRL|rcsb pdb:3KXX|rcsb pdb:3KY2|rcsb pdb:3OJV|rcsb pdb:3RHX|rcsb pdb:3TT0|rcsb pdb:4F63|rcsb pdb:4F64|rcsb pdb:4F65|rcsb pdb:4NK9|rcsb pdb:4NKA|rcsb pdb:4NKS|rcsb pdb:4RWI|rcsb pdb:4RWJ|rcsb pdb:4RWK|rcsb pdb:4RWL|rcsb pdb:4UWC|rcsb pdb:4UWY|rcsb pdb:4V01|rcsb pdb:4V04|rcsb pdb:4V05|rcsb pdb:4WUN|rcsb pdb:4ZSA|rcsb pdb:5A46|rcsb pdb:5A4C|rcsb pdb:5AM6|rcsb pdb:5AM7|rcsb pdb:5B7V|rcsb pdb:5EW8|rcsb pdb:5FLF|rcsb pdb:5O49|rcsb pdb:5O4A|rcsb pdb:5UQ0|rcsb pdb:5UR1|rcsb pdb:5VND|rcsb pdb:5W21|rcsb pdb:5W59|rcsb pdb:5Z0S|rcsb pdb:5ZV2|rcsb pdb:6C18|rcsb pdb:6C19|rcsb pdb:6C1B|rcsb pdb:6C1C|rcsb pdb:6C1O|rcsb pdb:6ITJ|rcsb pdb:6MZQ|rcsb pdb:6MZW|rcsb pdb:6NVL|rcsb pdb:6P68|rcsb pdb:6P69|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839120|rcsb pdb:4UWB|reactome:R-HSA-1839122|reactome:R-HSA-190370|reactome:R-HSA-190373|reactome:R-HSA-190374|reactome:R-HSA-2219530|reactome:R-HSA-375165|reactome:R-HSA-445144|reactome:R-HSA-5654219|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853336|reactome:R-HSA-5654726|dip:DIP-4019N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:Dfm7x2YNSSjehHi6KkwC/Gzpjsg9606 rogid:th/BEfNYh60oKK7G0HFX+O1pXh89606 rigid:mGY4FiwPR/Pa6zosnaH+uUvUz1s false binding-associated region:28-251 binding-associated region:142-365 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q61851-1 uniprotkb:Q9GZV9 intact:EBI-15820536 intact:EBI-6594125|ensembl:ENSP00000237837|uniprotkb:Q4V758 psi-mi:q61851-1(display_long)|uniprotkb:Fgfr3(gene name)|psi-mi:Fgfr3(display_short)|uniprotkb:Mfr3(gene name synonym)|uniprotkb:Sam3(gene name synonym)|uniprotkb:IIIc(isoform synonym)|uniprotkb:Heparin-binding growth factor receptor(gene name synonym) psi-mi:fgf23_human(display_long)|uniprotkb:FGF23(gene name)|psi-mi:FGF23(display_short)|uniprotkb:HYPF(gene name synonym)|uniprotkb:Phosphatonin(gene name synonym)|uniprotkb:Tumor-derived hypophosphatemia-inducing factor(gene name synonym)|uniprotkb:UNQ3027/PRO9828(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goetz et al. (2010) pubmed:19966287|doi:10.1073/pnas.0902006107|imex:IM-14912 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15820611|imex:IM-14912-6|dip:DIP-185473E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6287052(isoform-parent) ensembl:ENSG00000118972(gene)|ensembl:ENST00000237837(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005105"(type 1 fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0010980"(positive regulation of vitamin D 24-hydroxylase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0042369"(vitamin D catabolic process)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:1904383"(response to sodium phosphate)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028304|rcsb pdb:2P39|rcsb pdb:5W21|rcsb pdb:6S22|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190322|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190374|reactome:R-HSA-190375|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-381426|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853338|reactome:R-HSA-8957275|refseq:NP_065689.1|dip:DIP-58507N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:3jdly+HWh0GwI6obkw98fhYrj0k10090 rogid:Dfm7x2YNSSjehHi6KkwC/Gzpjsg9606 rigid:AgdAVCIsrbYpAZO7K9zNVJV38Pw false v5 tag:c-c sufficient binding region:180-251 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q61851-1 uniprotkb:O35082 intact:EBI-15820536 intact:EBI-1570828|uniprotkb:O70175|uniprotkb:O70621|uniprotkb:B2RR78|ensembl:ENSMUSP00000077899 psi-mi:q61851-1(display_long)|uniprotkb:Fgfr3(gene name)|psi-mi:Fgfr3(display_short)|uniprotkb:Mfr3(gene name synonym)|uniprotkb:Sam3(gene name synonym)|uniprotkb:IIIc(isoform synonym)|uniprotkb:Heparin-binding growth factor receptor(gene name synonym) psi-mi:klot_mouse(display_long)|uniprotkb:Kl(gene name)|psi-mi:Kl(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goetz et al. (2010) pubmed:19966287|doi:10.1073/pnas.0902006107|imex:IM-14912 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15820611|imex:IM-14912-6|dip:DIP-185473E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6287052(isoform-parent) refseq:NP_038851.2|dip:DIP-39894N|ensembl:ENSMUSG00000058488(gene)|ensembl:ENSMUST00000078856(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0004566"(beta-glucuronidase activity)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008422"(beta-glucosidase activity)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028546|interpro:IPR033132|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190374|reactome:R-MMU-5654219|reactome:R-MMU-5654687|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654726|reactome:R-MMU-5673001|reactome:R-MMU-6811558 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:3jdly+HWh0GwI6obkw98fhYrj0k10090 rogid:rj/Wc7xYgFTXmP6J9nzgH5rJuhc10090 rigid:AgdAVCIsrbYpAZO7K9zNVJV38Pw false v5 tag:c-c flag tag:c-c|binding-associated region:35-982 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P16092 uniprotkb:Q9GZV9 intact:EBI-7953898|uniprotkb:Q60830|uniprotkb:Q01736|uniprotkb:Q8CFK8|intact:MINT-2635590|uniprotkb:Q80T10|uniprotkb:E9Q2P4|uniprotkb:Q61562|uniprotkb:Q9QZM7|ensembl:ENSMUSP00000081041 intact:EBI-6594125|ensembl:ENSP00000237837|uniprotkb:Q4V758 psi-mi:fgfr1_mouse(display_long)|uniprotkb:Fgfr1(gene name)|psi-mi:Fgfr1(display_short)|uniprotkb:Flg(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:MFR(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym) psi-mi:fgf23_human(display_long)|uniprotkb:FGF23(gene name)|psi-mi:FGF23(display_short)|uniprotkb:HYPF(gene name synonym)|uniprotkb:Phosphatonin(gene name synonym)|uniprotkb:Tumor-derived hypophosphatemia-inducing factor(gene name synonym)|uniprotkb:UNQ3027/PRO9828(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goetz et al. (2010) pubmed:19966287|doi:10.1073/pnas.0902006107|imex:IM-14912 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15820638|imex:IM-14912-7|dip:DIP-185466E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011240423.1|refseq:NP_034336.2|refseq:NP_001073378.1|refseq:NP_001073377.1|refseq:XP_006509073.1|refseq:XP_006509075.1|dip:DIP-6033N|ensembl:ENSMUSG00000031565(gene)|ensembl:ENSMUST00000084027(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001759"(organ induction)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0021837"(motogenic signaling involved in postnatal olfactory bulb interneuron migration)|go:"GO:0021847"(ventricular zone neuroblast division)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030901"(midbrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035607"(fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043583"(ear development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR028174|interpro:IPR036179|interpro:IPR041159|mint:P16092|rcsb pdb:2CKN|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190370|reactome:R-MMU-190373|reactome:R-MMU-190374|reactome:R-MMU-445144|reactome:R-MMU-5654219|reactome:R-MMU-5654687|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654726|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048699"(generation of neurons)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051174"(regulation of phosphorus metabolic process)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060117"(auditory receptor cell development)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060665"(regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0070640"(vitamin D3 metabolic process)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:0090272"(negative regulation of fibroblast growth factor production)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1903465"(positive regulation of mitotic cell cycle DNA replication)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000830"(positive regulation of parathyroid hormone secretion)|go:"GO:2001239"(regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor) ensembl:ENSG00000118972(gene)|ensembl:ENST00000237837(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005105"(type 1 fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0010980"(positive regulation of vitamin D 24-hydroxylase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0042369"(vitamin D catabolic process)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:1904383"(response to sodium phosphate)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028304|rcsb pdb:2P39|rcsb pdb:5W21|rcsb pdb:6S22|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190322|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190374|reactome:R-HSA-190375|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-381426|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853338|reactome:R-HSA-8957275|refseq:NP_065689.1|dip:DIP-58507N psi-mi:"MI:0465"(dip) comment:mint|function:"Receptor for basic fibroblast growth factor. A shorter form of the receptor could be a receptor for FGF1 (aFGF)"|comment:homomint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:JSLRQxD7C6jJyldtTkRE1Zn+AvE10090 rogid:Dfm7x2YNSSjehHi6KkwC/Gzpjsg9606 rigid:OIXAQx8uWdfPU2kHRwpxFZC7F1k false v5 tag:c-c sufficient binding region:180-251 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P16092 uniprotkb:O35082 intact:EBI-7953898|uniprotkb:Q60830|uniprotkb:Q01736|uniprotkb:Q8CFK8|intact:MINT-2635590|uniprotkb:Q80T10|uniprotkb:E9Q2P4|uniprotkb:Q61562|uniprotkb:Q9QZM7|ensembl:ENSMUSP00000081041 intact:EBI-1570828|uniprotkb:O70175|uniprotkb:O70621|uniprotkb:B2RR78|ensembl:ENSMUSP00000077899 psi-mi:fgfr1_mouse(display_long)|uniprotkb:Fgfr1(gene name)|psi-mi:Fgfr1(display_short)|uniprotkb:Flg(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:MFR(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym) psi-mi:klot_mouse(display_long)|uniprotkb:Kl(gene name)|psi-mi:Kl(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goetz et al. (2010) pubmed:19966287|doi:10.1073/pnas.0902006107|imex:IM-14912 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15820638|imex:IM-14912-7|dip:DIP-185466E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011240423.1|refseq:NP_034336.2|refseq:NP_001073378.1|refseq:NP_001073377.1|refseq:XP_006509073.1|refseq:XP_006509075.1|dip:DIP-6033N|ensembl:ENSMUSG00000031565(gene)|ensembl:ENSMUST00000084027(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001759"(organ induction)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0021837"(motogenic signaling involved in postnatal olfactory bulb interneuron migration)|go:"GO:0021847"(ventricular zone neuroblast division)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030901"(midbrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035607"(fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043583"(ear development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR028174|interpro:IPR036179|interpro:IPR041159|mint:P16092|rcsb pdb:2CKN|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190370|reactome:R-MMU-190373|reactome:R-MMU-190374|reactome:R-MMU-445144|reactome:R-MMU-5654219|reactome:R-MMU-5654687|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654726|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048699"(generation of neurons)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051174"(regulation of phosphorus metabolic process)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060117"(auditory receptor cell development)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060665"(regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0070640"(vitamin D3 metabolic process)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:0090272"(negative regulation of fibroblast growth factor production)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1903465"(positive regulation of mitotic cell cycle DNA replication)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000830"(positive regulation of parathyroid hormone secretion)|go:"GO:2001239"(regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor) refseq:NP_038851.2|dip:DIP-39894N|ensembl:ENSMUSG00000058488(gene)|ensembl:ENSMUST00000078856(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0004566"(beta-glucuronidase activity)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008422"(beta-glucosidase activity)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028546|interpro:IPR033132|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190374|reactome:R-MMU-5654219|reactome:R-MMU-5654687|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654726|reactome:R-MMU-5673001|reactome:R-MMU-6811558 psi-mi:"MI:0465"(dip) comment:mint|function:"Receptor for basic fibroblast growth factor. A shorter form of the receptor could be a receptor for FGF1 (aFGF)"|comment:homomint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:JSLRQxD7C6jJyldtTkRE1Zn+AvE10090 rogid:rj/Wc7xYgFTXmP6J9nzgH5rJuhc10090 rigid:OIXAQx8uWdfPU2kHRwpxFZC7F1k false v5 tag:c-c flag tag:c-c|binding-associated region:35-982 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O35082 uniprotkb:Q03142 intact:EBI-1570828|uniprotkb:O70175|uniprotkb:O70621|uniprotkb:B2RR78|ensembl:ENSMUSP00000077899 intact:EBI-15633599|uniprotkb:Q27Q87|uniprotkb:Q5J7D9|uniprotkb:Q8C3V5|uniprotkb:Q8CIB8 psi-mi:klot_mouse(display_long)|uniprotkb:Kl(gene name)|psi-mi:Kl(display_short) psi-mi:fgfr4_mouse(display_long)|uniprotkb:Fgfr4(gene name)|psi-mi:Fgfr4(display_short)|uniprotkb:Fgfr-4(gene name synonym)|uniprotkb:Mpk-11(gene name synonym)|uniprotkb:Protein-tyrosine kinase receptor MPK-11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goetz et al. (2010) pubmed:19966287|doi:10.1073/pnas.0902006107|imex:IM-14912 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15820734|imex:IM-14912-11|dip:DIP-185468E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038851.2|dip:DIP-39894N|ensembl:ENSMUSG00000058488(gene)|ensembl:ENSMUST00000078856(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0004566"(beta-glucuronidase activity)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008422"(beta-glucosidase activity)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028546|interpro:IPR033132|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190374|reactome:R-MMU-5654219|reactome:R-MMU-5654687|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654726|reactome:R-MMU-5673001|reactome:R-MMU-6811558 go:"GO:0001759"(organ induction)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010715"(regulation of extracellular matrix disassembly)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030133"(transport vesicle)|go:"GO:0030324"(lung development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051174"(regulation of phosphorus metabolic process)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0061144"(alveolar secondary septum development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070640"(vitamin D3 metabolic process)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0090272"(negative regulation of fibroblast growth factor production)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000830"(positive regulation of parathyroid hormone secretion)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-1307965|reactome:R-MMU-190322|reactome:R-MMU-5654228|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654733|reactome:R-MMU-5673001|reactome:R-MMU-6811558|refseq:NP_032037.2|dip:DIP-58508N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:rj/Wc7xYgFTXmP6J9nzgH5rJuhc10090 rogid:GydxGsNVSaRi7sQhqMDfj6Q7c9I10090 rigid:omJYVlIxW+PTtZXZJ+6Coo1dnkY false binding-associated region:35-982|flag tag:c-c v5 tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O35082 uniprotkb:Q9GZV9 intact:EBI-1570828|uniprotkb:O70175|uniprotkb:O70621|uniprotkb:B2RR78|ensembl:ENSMUSP00000077899 intact:EBI-6594125|ensembl:ENSP00000237837|uniprotkb:Q4V758 psi-mi:klot_mouse(display_long)|uniprotkb:Kl(gene name)|psi-mi:Kl(display_short) psi-mi:fgf23_human(display_long)|uniprotkb:FGF23(gene name)|psi-mi:FGF23(display_short)|uniprotkb:HYPF(gene name synonym)|uniprotkb:Phosphatonin(gene name synonym)|uniprotkb:Tumor-derived hypophosphatemia-inducing factor(gene name synonym)|uniprotkb:UNQ3027/PRO9828(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goetz et al. (2010) pubmed:19966287|doi:10.1073/pnas.0902006107|imex:IM-14912 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15820709|imex:IM-14912-10|dip:DIP-185470E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038851.2|dip:DIP-39894N|ensembl:ENSMUSG00000058488(gene)|ensembl:ENSMUST00000078856(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0004566"(beta-glucuronidase activity)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008422"(beta-glucosidase activity)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028546|interpro:IPR033132|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190374|reactome:R-MMU-5654219|reactome:R-MMU-5654687|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654726|reactome:R-MMU-5673001|reactome:R-MMU-6811558 ensembl:ENSG00000118972(gene)|ensembl:ENST00000237837(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005105"(type 1 fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0010980"(positive regulation of vitamin D 24-hydroxylase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0042369"(vitamin D catabolic process)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:1904383"(response to sodium phosphate)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028304|rcsb pdb:2P39|rcsb pdb:5W21|rcsb pdb:6S22|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190322|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190374|reactome:R-HSA-190375|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-381426|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853338|reactome:R-HSA-8957275|refseq:NP_065689.1|dip:DIP-58507N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:rj/Wc7xYgFTXmP6J9nzgH5rJuhc10090 rogid:Dfm7x2YNSSjehHi6KkwC/Gzpjsg9606 rigid:nJtYO0o+LexiT5aAbqfpVKHxktY false binding-associated region:35-982|flag tag:c-c sufficient binding region:180-251|sufficient binding region:28-200 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O35082 uniprotkb:Q9GZV9 intact:EBI-1570828|uniprotkb:O70175|uniprotkb:O70621|uniprotkb:B2RR78|ensembl:ENSMUSP00000077899 intact:EBI-6594125|ensembl:ENSP00000237837|uniprotkb:Q4V758 psi-mi:klot_mouse(display_long)|uniprotkb:Kl(gene name)|psi-mi:Kl(display_short) psi-mi:fgf23_human(display_long)|uniprotkb:FGF23(gene name)|psi-mi:FGF23(display_short)|uniprotkb:HYPF(gene name synonym)|uniprotkb:Phosphatonin(gene name synonym)|uniprotkb:Tumor-derived hypophosphatemia-inducing factor(gene name synonym)|uniprotkb:UNQ3027/PRO9828(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Goetz et al. (2010) pubmed:19966287|doi:10.1073/pnas.0902006107|imex:IM-14912 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15820688|imex:IM-14912-9|dip:DIP-185470E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038851.2|dip:DIP-39894N|ensembl:ENSMUSG00000058488(gene)|ensembl:ENSMUST00000078856(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0004566"(beta-glucuronidase activity)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008422"(beta-glucosidase activity)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028546|interpro:IPR033132|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190374|reactome:R-MMU-5654219|reactome:R-MMU-5654687|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654726|reactome:R-MMU-5673001|reactome:R-MMU-6811558 ensembl:ENSG00000118972(gene)|ensembl:ENST00000237837(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005105"(type 1 fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0010980"(positive regulation of vitamin D 24-hydroxylase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0042369"(vitamin D catabolic process)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:1904383"(response to sodium phosphate)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028304|rcsb pdb:2P39|rcsb pdb:5W21|rcsb pdb:6S22|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190322|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190374|reactome:R-HSA-190375|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-381426|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853338|reactome:R-HSA-8957275|refseq:NP_065689.1|dip:DIP-58507N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:rj/Wc7xYgFTXmP6J9nzgH5rJuhc10090 rogid:Dfm7x2YNSSjehHi6KkwC/Gzpjsg9606 rigid:nJtYO0o+LexiT5aAbqfpVKHxktY false binding-associated region:35-982 binding-associated region:28-251 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9GZV9 uniprotkb:P11362 intact:EBI-6594125|ensembl:ENSP00000237837|uniprotkb:Q4V758 intact:EBI-1028277|uniprotkb:P17049|uniprotkb:Q02063|uniprotkb:Q02065|uniprotkb:Q14306|uniprotkb:Q14307|uniprotkb:Q8N685|uniprotkb:C1KBH8|uniprotkb:Q9UDF0|uniprotkb:Q9UDF1|uniprotkb:Q9UDF2|uniprotkb:Q59H40|uniprotkb:Q5BJG2|uniprotkb:A8K6T9|uniprotkb:A8K8V5|uniprotkb:Q53H63|uniprotkb:Q9UD50|intact:EBI-1058611|ensembl:ENSP00000400162 psi-mi:fgf23_human(display_long)|uniprotkb:FGF23(gene name)|psi-mi:FGF23(display_short)|uniprotkb:HYPF(gene name synonym)|uniprotkb:Phosphatonin(gene name synonym)|uniprotkb:Tumor-derived hypophosphatemia-inducing factor(gene name synonym)|uniprotkb:UNQ3027/PRO9828(orf name) psi-mi:fgfr1_human(display_long)|uniprotkb:FGFR1(gene name)|psi-mi:FGFR1(display_short)|uniprotkb:FGFBR(gene name synonym)|uniprotkb:FLG(gene name synonym)|uniprotkb:FLT2(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 2(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:BFGFR(gene name synonym)|uniprotkb:CEK(gene name synonym)|uniprotkb:HBGFR(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:N-sam(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Goetz et al. (2010) pubmed:19966287|doi:10.1073/pnas.0902006107|imex:IM-14912 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15820664|imex:IM-14912-8|dip:DIP-185471E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000118972(gene)|ensembl:ENST00000237837(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005105"(type 1 fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0010980"(positive regulation of vitamin D 24-hydroxylase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0042369"(vitamin D catabolic process)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:1904383"(response to sodium phosphate)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028304|rcsb pdb:2P39|rcsb pdb:5W21|rcsb pdb:6S22|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190322|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190374|reactome:R-HSA-190375|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-381426|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853338|reactome:R-HSA-8957275|refseq:NP_065689.1|dip:DIP-58507N refseq:NP_001167534.1|refseq:NP_001167535.1|refseq:NP_001167536.1|refseq:NP_001167537.1|refseq:NP_001167538.1|refseq:NP_056934.2|refseq:NP_075593.1|refseq:NP_075594.1|refseq:NP_075598.2|ensembl:ENSG00000077782(gene)|ensembl:ENST00000447712(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001501"(skeletal system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2001239"(regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR028174|interpro:IPR036179|interpro:IPR041159|mint:P11362|rcsb pdb:1AGW|rcsb pdb:1CVS|rcsb pdb:1EVT|rcsb pdb:1FGI|rcsb pdb:1FGK|rcsb pdb:1FQ9|go:"GO:0045666"(positive regulation of neuron differentiation)|rcsb pdb:1XR0|rcsb pdb:2CR3|rcsb pdb:2FGI|rcsb pdb:3C4F|rcsb pdb:3DPK|rcsb pdb:3GQI|rcsb pdb:3GQL|rcsb pdb:3JS2|rcsb pdb:3KRJ|rcsb pdb:3KRL|rcsb pdb:3KXX|rcsb pdb:3KY2|rcsb pdb:3OJV|rcsb pdb:3RHX|rcsb pdb:3TT0|rcsb pdb:4F63|rcsb pdb:4F64|rcsb pdb:4F65|rcsb pdb:4NK9|rcsb pdb:4NKA|rcsb pdb:4NKS|rcsb pdb:4RWI|rcsb pdb:4RWJ|rcsb pdb:4RWK|rcsb pdb:4RWL|rcsb pdb:4UWC|rcsb pdb:4UWY|rcsb pdb:4V01|rcsb pdb:4V04|rcsb pdb:4V05|rcsb pdb:4WUN|rcsb pdb:4ZSA|rcsb pdb:5A46|rcsb pdb:5A4C|rcsb pdb:5AM6|rcsb pdb:5AM7|rcsb pdb:5B7V|rcsb pdb:5EW8|rcsb pdb:5FLF|rcsb pdb:5O49|rcsb pdb:5O4A|rcsb pdb:5UQ0|rcsb pdb:5UR1|rcsb pdb:5VND|rcsb pdb:5W21|rcsb pdb:5W59|rcsb pdb:5Z0S|rcsb pdb:5ZV2|rcsb pdb:6C18|rcsb pdb:6C19|rcsb pdb:6C1B|rcsb pdb:6C1C|rcsb pdb:6C1O|rcsb pdb:6ITJ|rcsb pdb:6MZQ|rcsb pdb:6MZW|rcsb pdb:6NVL|rcsb pdb:6P68|rcsb pdb:6P69|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839120|rcsb pdb:4UWB|reactome:R-HSA-1839122|reactome:R-HSA-190370|reactome:R-HSA-190373|reactome:R-HSA-190374|reactome:R-HSA-2219530|reactome:R-HSA-375165|reactome:R-HSA-445144|reactome:R-HSA-5654219|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853336|reactome:R-HSA-5654726|dip:DIP-4019N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:Dfm7x2YNSSjehHi6KkwC/Gzpjsg9606 rogid:th/BEfNYh60oKK7G0HFX+O1pXh89606 rigid:mBfkPKboaPDvz2ZAsy/GZ/Wmhks false sufficient binding region:180-251 binding-associated region:142-365 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q9GZV9 uniprotkb:O35082 intact:EBI-6594125|ensembl:ENSP00000237837|uniprotkb:Q4V758 intact:EBI-1570828|uniprotkb:O70175|uniprotkb:O70621|uniprotkb:B2RR78|ensembl:ENSMUSP00000077899 psi-mi:fgf23_human(display_long)|uniprotkb:FGF23(gene name)|psi-mi:FGF23(display_short)|uniprotkb:HYPF(gene name synonym)|uniprotkb:Phosphatonin(gene name synonym)|uniprotkb:Tumor-derived hypophosphatemia-inducing factor(gene name synonym)|uniprotkb:UNQ3027/PRO9828(orf name) psi-mi:klot_mouse(display_long)|uniprotkb:Kl(gene name)|psi-mi:Kl(display_short) psi-mi:"MI:0071"(molecular sieving) Goetz et al. (2010) pubmed:19966287|doi:10.1073/pnas.0902006107|imex:IM-14912 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15820664|imex:IM-14912-8|dip:DIP-185471E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000118972(gene)|ensembl:ENST00000237837(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005105"(type 1 fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0010980"(positive regulation of vitamin D 24-hydroxylase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0042369"(vitamin D catabolic process)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:1904383"(response to sodium phosphate)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028304|rcsb pdb:2P39|rcsb pdb:5W21|rcsb pdb:6S22|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190322|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190374|reactome:R-HSA-190375|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-381426|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853338|reactome:R-HSA-8957275|refseq:NP_065689.1|dip:DIP-58507N refseq:NP_038851.2|dip:DIP-39894N|ensembl:ENSMUSG00000058488(gene)|ensembl:ENSMUST00000078856(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0004566"(beta-glucuronidase activity)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008422"(beta-glucosidase activity)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028546|interpro:IPR033132|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190374|reactome:R-MMU-5654219|reactome:R-MMU-5654687|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654726|reactome:R-MMU-5673001|reactome:R-MMU-6811558 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:Dfm7x2YNSSjehHi6KkwC/Gzpjsg9606 rogid:rj/Wc7xYgFTXmP6J9nzgH5rJuhc10090 rigid:mBfkPKboaPDvz2ZAsy/GZ/Wmhks false sufficient binding region:180-251 binding-associated region:35-982 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q03142 uniprotkb:Q9GZV9 intact:EBI-15633599|uniprotkb:Q27Q87|uniprotkb:Q5J7D9|uniprotkb:Q8C3V5|uniprotkb:Q8CIB8 intact:EBI-6594125|ensembl:ENSP00000237837|uniprotkb:Q4V758 psi-mi:fgfr4_mouse(display_long)|uniprotkb:Fgfr4(gene name)|psi-mi:Fgfr4(display_short)|uniprotkb:Fgfr-4(gene name synonym)|uniprotkb:Mpk-11(gene name synonym)|uniprotkb:Protein-tyrosine kinase receptor MPK-11(gene name synonym) psi-mi:fgf23_human(display_long)|uniprotkb:FGF23(gene name)|psi-mi:FGF23(display_short)|uniprotkb:HYPF(gene name synonym)|uniprotkb:Phosphatonin(gene name synonym)|uniprotkb:Tumor-derived hypophosphatemia-inducing factor(gene name synonym)|uniprotkb:UNQ3027/PRO9828(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goetz et al. (2010) pubmed:19966287|doi:10.1073/pnas.0902006107|imex:IM-14912 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15820757|imex:IM-14912-12|dip:DIP-185474E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001759"(organ induction)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010715"(regulation of extracellular matrix disassembly)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030133"(transport vesicle)|go:"GO:0030324"(lung development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051174"(regulation of phosphorus metabolic process)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0061144"(alveolar secondary septum development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070640"(vitamin D3 metabolic process)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0090272"(negative regulation of fibroblast growth factor production)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000830"(positive regulation of parathyroid hormone secretion)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-1307965|reactome:R-MMU-190322|reactome:R-MMU-5654228|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654733|reactome:R-MMU-5673001|reactome:R-MMU-6811558|refseq:NP_032037.2|dip:DIP-58508N ensembl:ENSG00000118972(gene)|ensembl:ENST00000237837(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005105"(type 1 fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0010980"(positive regulation of vitamin D 24-hydroxylase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0042369"(vitamin D catabolic process)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:1904383"(response to sodium phosphate)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028304|rcsb pdb:2P39|rcsb pdb:5W21|rcsb pdb:6S22|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190322|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190374|reactome:R-HSA-190375|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-381426|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853338|reactome:R-HSA-8957275|refseq:NP_065689.1|dip:DIP-58507N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:GydxGsNVSaRi7sQhqMDfj6Q7c9I10090 rogid:Dfm7x2YNSSjehHi6KkwC/Gzpjsg9606 rigid:77f4pnNPqu0T16IFzkYDEWdxydo false v5 tag:c-c sufficient binding region:180-251 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q03142 uniprotkb:O35082 intact:EBI-15633599|uniprotkb:Q27Q87|uniprotkb:Q5J7D9|uniprotkb:Q8C3V5|uniprotkb:Q8CIB8 intact:EBI-1570828|uniprotkb:O70175|uniprotkb:O70621|uniprotkb:B2RR78|ensembl:ENSMUSP00000077899 psi-mi:fgfr4_mouse(display_long)|uniprotkb:Fgfr4(gene name)|psi-mi:Fgfr4(display_short)|uniprotkb:Fgfr-4(gene name synonym)|uniprotkb:Mpk-11(gene name synonym)|uniprotkb:Protein-tyrosine kinase receptor MPK-11(gene name synonym) psi-mi:klot_mouse(display_long)|uniprotkb:Kl(gene name)|psi-mi:Kl(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goetz et al. (2010) pubmed:19966287|doi:10.1073/pnas.0902006107|imex:IM-14912 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15820757|imex:IM-14912-12|dip:DIP-185474E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001759"(organ induction)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010715"(regulation of extracellular matrix disassembly)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030133"(transport vesicle)|go:"GO:0030324"(lung development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051174"(regulation of phosphorus metabolic process)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0061144"(alveolar secondary septum development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070640"(vitamin D3 metabolic process)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0090272"(negative regulation of fibroblast growth factor production)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000830"(positive regulation of parathyroid hormone secretion)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-1307965|reactome:R-MMU-190322|reactome:R-MMU-5654228|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654733|reactome:R-MMU-5673001|reactome:R-MMU-6811558|refseq:NP_032037.2|dip:DIP-58508N refseq:NP_038851.2|dip:DIP-39894N|ensembl:ENSMUSG00000058488(gene)|ensembl:ENSMUST00000078856(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0004566"(beta-glucuronidase activity)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008422"(beta-glucosidase activity)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028546|interpro:IPR033132|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190374|reactome:R-MMU-5654219|reactome:R-MMU-5654687|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654726|reactome:R-MMU-5673001|reactome:R-MMU-6811558 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:GydxGsNVSaRi7sQhqMDfj6Q7c9I10090 rogid:rj/Wc7xYgFTXmP6J9nzgH5rJuhc10090 rigid:77f4pnNPqu0T16IFzkYDEWdxydo false v5 tag:c-c flag tag:c-c|binding-associated region:35-982 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)