#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9VG38 uniprotkb:P19538 intact:EBI-110605|ensemblmetazoa:FBpp0082134 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 psi-mi:q9vg38_drome(display_long)|uniprotkb:"Su(fu)"(gene name)|psi-mi:"Su(fu)"(display_short)|uniprotkb:CG6054(orf name)|uniprotkb:Dmel\CG6054(gene name synonym)|uniprotkb:"SU(FU)"(gene name synonym)|uniprotkb:SUFU(gene name synonym)|uniprotkb:"Su(Fu)"(gene name synonym)|uniprotkb:SuFu(gene name synonym)|uniprotkb:Sufu(gene name synonym)|uniprotkb:dSufu(gene name synonym)|uniprotkb:"su(fu)"(gene name synonym)|uniprotkb:sufu(gene name synonym)|uniprotkb:Dmel_CG6054(orf name)|uniprotkb:d Sufu(gene name synonym) psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15818373|imex:IM-22463-1|dip:DIP-196199E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_536750.2|flybase:FBgn0005355|dip:DIP-60773N|ensemblmetazoa:FBgn0005355(gene)|ensemblmetazoa:FBtr0082665(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046823"(negative regulation of nucleocytoplasmic transport)|go:"GO:0140311"(protein sequestering activity)|interpro:IPR007768(Suppressor of fused)|interpro:IPR016591(Suppressor of fused protein)|interpro:IPR020941|interpro:IPR024314|interpro:IPR037181|interpro:IPR038489|rcsb pdb:4KMA|rcsb pdb:6LPH|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684 refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:bgRdXcd2LSsl7sfv4ArpqgWFzeU7227 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rigid:+RKQDOLoQHupscqcPxD6ROorEe0 false - sufficient binding region:1-212|sufficient binding region:212-268 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9VFP2-2 uniprotkb:P19538 intact:EBI-15659276|ensemblmetazoa:FBpp0290847 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 psi-mi:q9vfp2-2(display_long)|uniprotkb:HIB(gene name synonym)|uniprotkb:Hh-induced MATH and BTB domain-containing protein(gene name synonym)|uniprotkb:CG12537(orf name)|uniprotkb:B(isoform synonym)|uniprotkb:rdx(gene name)|psi-mi:rdx(display_short) psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15818467|imex:IM-22463-5|dip:DIP-196192E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-132658(isoform-parent)|ensemblmetazoa:FBgn0264493(gene)|ensemblmetazoa:FBtr0301633(transcript) refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/10 rogid:wK8MgTf5GOHgmS5XgIMphs8z+oE7227 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rigid:l1DiCtexMnZJAtcN0KLPnImBiw8 false flag tag:?-? myc tag:n-n|sufficient binding region:1-440|sufficient binding region:1160-1377 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9VFP2-2 uniprotkb:P19538 intact:EBI-15659276|ensemblmetazoa:FBpp0290847 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 psi-mi:q9vfp2-2(display_long)|uniprotkb:HIB(gene name synonym)|uniprotkb:Hh-induced MATH and BTB domain-containing protein(gene name synonym)|uniprotkb:CG12537(orf name)|uniprotkb:B(isoform synonym)|uniprotkb:rdx(gene name)|psi-mi:rdx(display_short) psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15818444|imex:IM-22463-4|dip:DIP-196192E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-132658(isoform-parent)|ensemblmetazoa:FBgn0264493(gene)|ensemblmetazoa:FBtr0301633(transcript) refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/10 rogid:wK8MgTf5GOHgmS5XgIMphs8z+oE7227 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rigid:l1DiCtexMnZJAtcN0KLPnImBiw8 false myc tag:?-? ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O16844 uniprotkb:O16844 intact:EBI-102069|intact:EBI-868718|intact:EBI-1151174|intact:EBI-497208|uniprotkb:A1Z6X4|uniprotkb:B5RIP3|uniprotkb:Q6AWI9|uniprotkb:Q8IH04|ensemblmetazoa:FBpp0088087|ensemblmetazoa:FBpp0307854 intact:EBI-102069|intact:EBI-868718|intact:EBI-1151174|intact:EBI-497208|uniprotkb:A1Z6X4|uniprotkb:B5RIP3|uniprotkb:Q6AWI9|uniprotkb:Q8IH04|ensemblmetazoa:FBpp0088087|ensemblmetazoa:FBpp0307854 psi-mi:cos_drome(display_long)|uniprotkb:cos(gene name)|psi-mi:cos(display_short)|uniprotkb:cos2(gene name synonym)|uniprotkb:costal-2(gene name synonym)|uniprotkb:Kinesin-like protein costal2(gene name synonym)|uniprotkb:CG1708(orf name) psi-mi:cos_drome(display_long)|uniprotkb:cos(gene name)|psi-mi:cos(display_short)|uniprotkb:cos2(gene name synonym)|uniprotkb:costal-2(gene name synonym)|uniprotkb:Kinesin-like protein costal2(gene name synonym)|uniprotkb:CG1708(orf name) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:2364"(proximity) psi-mi:"MI:0465"(DIP) intact:EBI-15818423|imex:IM-22463-3|dip:DIP-196198E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477092.1|flybase:FBgn0000352|ensemblmetazoa:FBgn0000352(gene)|ensemblmetazoa:FBtr0089015(transcript)|ensemblmetazoa:FBtr0336916(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005119"(smoothened binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_001260765.1|dip:DIP-22550N refseq:NP_477092.1|flybase:FBgn0000352|ensemblmetazoa:FBgn0000352(gene)|ensemblmetazoa:FBtr0089015(transcript)|ensemblmetazoa:FBtr0336916(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005119"(smoothened binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_001260765.1|dip:DIP-22550N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/10 rogid:6k5Ur6D1FPXovKN/UUjCoqKajQk7227 rogid:6k5Ur6D1FPXovKN/UUjCoqKajQk7227 rigid:PYCiouJceYUvairRi4FtPYFyfjE false yellow fluorescent protein tag:c-c cyan fluorescent protein tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9VFP2-2 uniprotkb:P19538 intact:EBI-15659276|ensemblmetazoa:FBpp0290847 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 psi-mi:q9vfp2-2(display_long)|uniprotkb:HIB(gene name synonym)|uniprotkb:Hh-induced MATH and BTB domain-containing protein(gene name synonym)|uniprotkb:CG12537(orf name)|uniprotkb:B(isoform synonym)|uniprotkb:rdx(gene name)|psi-mi:rdx(display_short) psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:"MI:0096"(pull down) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15818394|imex:IM-22463-2|dip:DIP-196192E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-132658(isoform-parent)|ensemblmetazoa:FBgn0264493(gene)|ensemblmetazoa:FBtr0301633(transcript) refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:wK8MgTf5GOHgmS5XgIMphs8z+oE7227 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rigid:l1DiCtexMnZJAtcN0KLPnImBiw8 false sufficient binding region:1-179|ha tag:?-? glutathione s tranferase tag:n-n|sufficient binding region:367-440|sufficient binding region:1239-1310 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P19538 uniprotkb:P19538 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:2364"(proximity) psi-mi:"MI:0465"(DIP) intact:EBI-15818494|imex:IM-22463-6|dip:DIP-45476E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/10 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rigid:M2kuvLtno9BZYhrmNoOjv03hmlI false yellow fluorescent protein tag:c-c cyan fluorescent protein tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9VFP2-2 uniprotkb:P19538 intact:EBI-15659276|ensemblmetazoa:FBpp0290847 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 psi-mi:q9vfp2-2(display_long)|uniprotkb:HIB(gene name synonym)|uniprotkb:Hh-induced MATH and BTB domain-containing protein(gene name synonym)|uniprotkb:CG12537(orf name)|uniprotkb:B(isoform synonym)|uniprotkb:rdx(gene name)|psi-mi:rdx(display_short) psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15818623|imex:IM-22463-11|dip:DIP-196192E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-132658(isoform-parent)|ensemblmetazoa:FBgn0264493(gene)|ensemblmetazoa:FBtr0301633(transcript) refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:wK8MgTf5GOHgmS5XgIMphs8z+oE7227 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rigid:l1DiCtexMnZJAtcN0KLPnImBiw8 false sufficient binding region:1-179 sufficient binding region:1-440 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9VFP2-2 uniprotkb:Q9VFP2-2 intact:EBI-15659276|ensemblmetazoa:FBpp0290847 intact:EBI-15659276|ensemblmetazoa:FBpp0290847 psi-mi:q9vfp2-2(display_long)|uniprotkb:HIB(gene name synonym)|uniprotkb:Hh-induced MATH and BTB domain-containing protein(gene name synonym)|uniprotkb:CG12537(orf name)|uniprotkb:B(isoform synonym)|uniprotkb:rdx(gene name)|psi-mi:rdx(display_short) psi-mi:q9vfp2-2(display_long)|uniprotkb:HIB(gene name synonym)|uniprotkb:Hh-induced MATH and BTB domain-containing protein(gene name synonym)|uniprotkb:CG12537(orf name)|uniprotkb:B(isoform synonym)|uniprotkb:rdx(gene name)|psi-mi:rdx(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15818594|imex:IM-22463-10|dip:DIP-196197E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-132658(isoform-parent)|ensemblmetazoa:FBgn0264493(gene)|ensemblmetazoa:FBtr0301633(transcript) intact:EBI-132658(isoform-parent)|ensemblmetazoa:FBgn0264493(gene)|ensemblmetazoa:FBtr0301633(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/10 rogid:wK8MgTf5GOHgmS5XgIMphs8z+oE7227 rogid:wK8MgTf5GOHgmS5XgIMphs8z+oE7227 rigid:uvxmCak2N97ftUs6D59wzboWNJA false sufficient binding region:180-374|ha tag:?-? myc tag:?-?|sufficient binding region:180-374 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9VFP2-2 uniprotkb:P19538 intact:EBI-15659276|ensemblmetazoa:FBpp0290847 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 psi-mi:q9vfp2-2(display_long)|uniprotkb:HIB(gene name synonym)|uniprotkb:Hh-induced MATH and BTB domain-containing protein(gene name synonym)|uniprotkb:CG12537(orf name)|uniprotkb:B(isoform synonym)|uniprotkb:rdx(gene name)|psi-mi:rdx(display_short) psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15818567|imex:IM-22463-9|dip:DIP-196192E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-132658(isoform-parent)|ensemblmetazoa:FBgn0264493(gene)|ensemblmetazoa:FBtr0301633(transcript) refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/10 rogid:wK8MgTf5GOHgmS5XgIMphs8z+oE7227 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rigid:l1DiCtexMnZJAtcN0KLPnImBiw8 false myc tag:?-?|sufficient binding region:1-179 ha tag:n-n|sufficient binding region:1-440 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9VHV8 uniprotkb:Q9VFP2-2 intact:EBI-193532|ensemblmetazoa:FBpp0081288 intact:EBI-15659276|ensemblmetazoa:FBpp0290847 psi-mi:q9vhv8_drome(display_long)|uniprotkb:puc(gene name)|psi-mi:puc(display_short)|uniprotkb:0238(gene name synonym)|uniprotkb:03(gene name synonym)|uniprotkb:08(gene name synonym)|uniprotkb:1351(gene name synonym)|uniprotkb:Dmel\CG7850(gene name synonym)|uniprotkb:JNK-DSP(gene name synonym)|uniprotkb:MKP(gene name synonym)|uniprotkb:PUC(gene name synonym)|uniprotkb:Puc(gene name synonym)|uniprotkb:hrt(gene name synonym)|uniprotkb:"l(3)84Eh"(gene name synonym)|uniprotkb:"l(3)A251.1"(gene name synonym)|uniprotkb:"l(3)j4E1"(gene name synonym)|uniprotkb:vco(gene name synonym)|uniprotkb:Dmel_CG7850(orf name)|uniprotkb:CG7850(orf name) psi-mi:q9vfp2-2(display_long)|uniprotkb:HIB(gene name synonym)|uniprotkb:Hh-induced MATH and BTB domain-containing protein(gene name synonym)|uniprotkb:CG12537(orf name)|uniprotkb:B(isoform synonym)|uniprotkb:rdx(gene name)|psi-mi:rdx(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15818544|imex:IM-22463-8|dip:DIP-196194E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524273.1|flybase:FBgn0243512|dip:DIP-60771N|ensemblmetazoa:FBgn0243512(gene)|ensemblmetazoa:FBtr0081792(transcript)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007254"(JNK cascade)|go:"GO:0007391"(dorsal closure)|go:"GO:0007561"(imaginal disc eversion)|go:"GO:0008330"(protein tyrosine/threonine phosphatase activity)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008362"(chitin-based embryonic cuticle biosynthetic process)|go:"GO:0008544"(epidermis development)|go:"GO:0008579"(JUN kinase phosphatase activity)|go:"GO:0009306"(protein secretion)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0017017"(MAP kinase tyrosine/serine/threonine phosphatase activity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042060"(wound healing)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046528"(imaginal disc fusion)|go:"GO:0046529"(imaginal disc fusion, thorax closure)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046844"(chorion micropyle formation)|go:"GO:0048615"("embryonic anterior midgut (ectodermal) morphogenesis")|go:"GO:0048749"(compound eye development)|go:"GO:0048803"(imaginal disc-derived male genitalia morphogenesis)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061060"(negative regulation of peptidoglycan recognition protein signaling pathway)|go:"GO:0070303"(negative regulation of stress-activated protein kinase signaling cascade)|go:"GO:0071907"(determination of digestive tract left/right asymmetry)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|rcsb pdb:3HQL|reactome:R-DME-112409|reactome:R-DME-5675221 intact:EBI-132658(isoform-parent)|ensemblmetazoa:FBgn0264493(gene)|ensemblmetazoa:FBtr0301633(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/10 rogid:MrLidgQ1MAZdihyl2UY4kfvuUUY7227 rogid:wK8MgTf5GOHgmS5XgIMphs8z+oE7227 rigid:EbO05KkKVm+Fu2KTGrlsWzjfVcM false myc tag:n-n flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9VFP2-2 uniprotkb:Q9VFP2-2 intact:EBI-15659276|ensemblmetazoa:FBpp0290847 intact:EBI-15659276|ensemblmetazoa:FBpp0290847 psi-mi:q9vfp2-2(display_long)|uniprotkb:HIB(gene name synonym)|uniprotkb:Hh-induced MATH and BTB domain-containing protein(gene name synonym)|uniprotkb:CG12537(orf name)|uniprotkb:B(isoform synonym)|uniprotkb:rdx(gene name)|psi-mi:rdx(display_short) psi-mi:q9vfp2-2(display_long)|uniprotkb:HIB(gene name synonym)|uniprotkb:Hh-induced MATH and BTB domain-containing protein(gene name synonym)|uniprotkb:CG12537(orf name)|uniprotkb:B(isoform synonym)|uniprotkb:rdx(gene name)|psi-mi:rdx(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15818515|imex:IM-22463-7|dip:DIP-196197E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-132658(isoform-parent)|ensemblmetazoa:FBgn0264493(gene)|ensemblmetazoa:FBtr0301633(transcript) intact:EBI-132658(isoform-parent)|ensemblmetazoa:FBgn0264493(gene)|ensemblmetazoa:FBtr0301633(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/10 rogid:wK8MgTf5GOHgmS5XgIMphs8z+oE7227 rogid:wK8MgTf5GOHgmS5XgIMphs8z+oE7227 rigid:uvxmCak2N97ftUs6D59wzboWNJA false sufficient binding region:1-179|ha tag:?-? myc tag:?-?|sufficient binding region:1-179 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19538 uniprotkb:P19538 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15818644|imex:IM-22463-12|dip:DIP-45476E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/10 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rigid:M2kuvLtno9BZYhrmNoOjv03hmlI false myc tag:n-n|sufficient binding region:1-212 flag tag:n-n|sufficient binding region:1-212 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9VFP2-2 uniprotkb:P19538 intact:EBI-15659276|ensemblmetazoa:FBpp0290847 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 psi-mi:q9vfp2-2(display_long)|uniprotkb:HIB(gene name synonym)|uniprotkb:Hh-induced MATH and BTB domain-containing protein(gene name synonym)|uniprotkb:CG12537(orf name)|uniprotkb:B(isoform synonym)|uniprotkb:rdx(gene name)|psi-mi:rdx(display_short) psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15818696|imex:IM-22463-14|dip:DIP-196192E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-132658(isoform-parent)|ensemblmetazoa:FBgn0264493(gene)|ensemblmetazoa:FBtr0301633(transcript) refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/10 rogid:wK8MgTf5GOHgmS5XgIMphs8z+oE7227 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rigid:l1DiCtexMnZJAtcN0KLPnImBiw8 false flag tag:?-? myc tag:n-n|sufficient binding region:1-440|sufficient binding region:1160-1306 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19538 uniprotkb:P19538 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15818669|imex:IM-22463-13|dip:DIP-45476E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/10 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rigid:M2kuvLtno9BZYhrmNoOjv03hmlI false sufficient binding region:1-440|sufficient binding region:440-1160|myc tag:n-n ha tag:n-n|sufficient binding region:1-686 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P68198 uniprotkb:P19538 intact:EBI-86340|uniprotkb:Q0E8I1|uniprotkb:Q9VKW6|uniprotkb:Q9VQX7|uniprotkb:Q9VZL4|dip:DIP-32843N intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 psi-mi:ubiq_drome(display_long)|uniprotkb:RpL40(gene name)|psi-mi:RpL40(display_short)|uniprotkb:CG2960(orf name)|uniprotkb:RpS27A(gene name)|psi-mi:RpS27A(display_short)|uniprotkb:UBI-F80(gene name synonym)|uniprotkb:Ubi-f(gene name synonym)|uniprotkb:CG5271(orf name)|uniprotkb:Ubi-p63E(gene name)|psi-mi:Ubi-p63E(display_short)|uniprotkb:Ubi-m(gene name synonym)|uniprotkb:CG11624(orf name) psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15818723|imex:IM-22463-15|dip:DIP-196193E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000626(Ubiquitin)|flybase:FBgn0003941(RpL40)|flybase:FBgn0003943(Ubi-p63E)|go:"GO:0006911"(phagocytosis, engulfment)|refseq:NP_476776.1|refseq:NP_476778.1|refseq:NP_728908.1|go:"GO:0005515"(protein binding)|flybase:FBgn0003942(RpS27A)|go:"GO:0030528"(obsolete transcription regulator activity)|go:"GO:0045941"|go:"GO:0016567"(protein ubiquitination)|go:"GO:0009408"(response to heat)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:FBgn0003943|ensembl:FBgn0003941|ensembl:FBgn0003942|refseq:NP_523909.2|refseq:NP_995994.1|ensembl:FBgn0086558 refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/15 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM7227 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rigid:RxMCzQYA5X21o9BLJindQesSw+c false ha tag:0-0 sufficient binding region:1-440|myc tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9VFP2-2 uniprotkb:P19538 intact:EBI-15659276|ensemblmetazoa:FBpp0290847 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 psi-mi:q9vfp2-2(display_long)|uniprotkb:HIB(gene name synonym)|uniprotkb:Hh-induced MATH and BTB domain-containing protein(gene name synonym)|uniprotkb:CG12537(orf name)|uniprotkb:B(isoform synonym)|uniprotkb:rdx(gene name)|psi-mi:rdx(display_short) psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15818769|imex:IM-22463-17|dip:DIP-196192E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-132658(isoform-parent)|ensemblmetazoa:FBgn0264493(gene)|ensemblmetazoa:FBtr0301633(transcript) refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/10 rogid:wK8MgTf5GOHgmS5XgIMphs8z+oE7227 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rigid:l1DiCtexMnZJAtcN0KLPnImBiw8 false myc tag:?-?|sufficient binding region:1-179 flag tag:n-n|sufficient binding region:1160-1377 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q6ZWS8 uniprotkb:P10071 intact:EBI-7128920|ensembl:ENSMUSP00000103350|ensembl:ENSMUSP00000103352|uniprotkb:Q3TLC2|uniprotkb:Q5ST07|intact:MINT-3982111|uniprotkb:Q76LV9 intact:EBI-308055|uniprotkb:A4D1W1|uniprotkb:O75219|uniprotkb:Q17RW4|uniprotkb:Q75MT0|uniprotkb:Q75MU9|uniprotkb:Q9UDT5|uniprotkb:Q9UJ39|ensembl:ENSP00000379258|ensembl:ENSP00000502957|ensembl:ENSP00000503743 psi-mi:spop_mouse(display_long)|uniprotkb:Spop(gene name)|psi-mi:Spop(display_short)|uniprotkb:Pcif1(gene name synonym)|uniprotkb:HIB homolog 1(gene name synonym)|uniprotkb:PDX-1 C-terminal-interacting factor 1(gene name synonym) psi-mi:gli3_human(display_long)|uniprotkb:GLI3(gene name)|psi-mi:GLI3(display_short)|uniprotkb:GLI3 full-length protein(gene name synonym)|uniprotkb:GLI3 form of 190 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15818746|imex:IM-22463-16|dip:DIP-196196E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006532755.1|ensembl:ENSMUSG00000057522(gene)|ensembl:ENSMUST00000107722(transcript)|ensembl:ENSMUST00000107724(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR034089|mint:Q6ZWS8|reactome:R-MMU-5632684|refseq:NP_079563.2|dip:DIP-43930N refseq:NP_000159.3|ensembl:ENSG00000106571(gene)|ensembl:ENST00000395925(transcript)|ensembl:ENST00000677605(transcript)|ensembl:ENST00000678429(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0016485"(protein processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0021775"(smoothened signaling pathway involved in ventral spinal cord interneuron specification)|go:"GO:0021776"(smoothened signaling pathway involved in spinal cord motor neuron cell fate specification)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0022018"(lateral ganglionic eminence cell proliferation)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030850"(prostate gland development)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036033"(mediator complex binding)|go:"GO:0042060"(wound healing)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0060594"(mammary gland specification)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0060840"(artery development)|go:"GO:0060873"(anterior semicircular canal development)|go:"GO:0060875"(lateral semicircular canal development)|go:"GO:0061005"(cell differentiation involved in kidney development)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071625"(vocalization behavior)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:0120223"(larynx morphogenesis)|go:"GO:1901620"(regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043585"(nose morphogenesis)|go:"GO:0043586"(tongue development)|go:"GO:0043627"(response to estrogen)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045665"(negative regulation of neuron differentiation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR032851|interpro:IPR036236|interpro:IPR043359|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|mint:P10071|rcsb pdb:4BLD|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5632684|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|reactome:R-HSA-5635851|reactome:R-HSA-8940973|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048589"(developmental growth)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060364"(frontal suture morphogenesis)|go:"GO:0060366"(lambdoid suture morphogenesis)|go:"GO:0060367"(sagittal suture morphogenesis)|dip:DIP-32538N psi-mi:"MI:0465"(dip) comment:mint|function:Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex. In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3 - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/10 rogid:PC9ofpvk14xwTnnqT590/YRnx/410090 rogid:BOHGgIuKgq0gUSahFeRaKnRmoMs9606 rigid:PRrzR9OWToFqs95XhvnMiL1WNGw false flag tag:n-n myc tag:n-n|sufficient binding region:1-660 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9VHV8 uniprotkb:Q9VFP2-2 intact:EBI-193532|ensemblmetazoa:FBpp0081288 intact:EBI-15659276|ensemblmetazoa:FBpp0290847 psi-mi:q9vhv8_drome(display_long)|uniprotkb:puc(gene name)|psi-mi:puc(display_short)|uniprotkb:0238(gene name synonym)|uniprotkb:03(gene name synonym)|uniprotkb:08(gene name synonym)|uniprotkb:1351(gene name synonym)|uniprotkb:Dmel\CG7850(gene name synonym)|uniprotkb:JNK-DSP(gene name synonym)|uniprotkb:MKP(gene name synonym)|uniprotkb:PUC(gene name synonym)|uniprotkb:Puc(gene name synonym)|uniprotkb:hrt(gene name synonym)|uniprotkb:"l(3)84Eh"(gene name synonym)|uniprotkb:"l(3)A251.1"(gene name synonym)|uniprotkb:"l(3)j4E1"(gene name synonym)|uniprotkb:vco(gene name synonym)|uniprotkb:Dmel_CG7850(orf name)|uniprotkb:CG7850(orf name) psi-mi:q9vfp2-2(display_long)|uniprotkb:HIB(gene name synonym)|uniprotkb:Hh-induced MATH and BTB domain-containing protein(gene name synonym)|uniprotkb:CG12537(orf name)|uniprotkb:B(isoform synonym)|uniprotkb:rdx(gene name)|psi-mi:rdx(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15818796|imex:IM-22463-18|dip:DIP-196194E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524273.1|flybase:FBgn0243512|dip:DIP-60771N|ensemblmetazoa:FBgn0243512(gene)|ensemblmetazoa:FBtr0081792(transcript)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007254"(JNK cascade)|go:"GO:0007391"(dorsal closure)|go:"GO:0007561"(imaginal disc eversion)|go:"GO:0008330"(protein tyrosine/threonine phosphatase activity)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008362"(chitin-based embryonic cuticle biosynthetic process)|go:"GO:0008544"(epidermis development)|go:"GO:0008579"(JUN kinase phosphatase activity)|go:"GO:0009306"(protein secretion)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0017017"(MAP kinase tyrosine/serine/threonine phosphatase activity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042060"(wound healing)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046528"(imaginal disc fusion)|go:"GO:0046529"(imaginal disc fusion, thorax closure)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046844"(chorion micropyle formation)|go:"GO:0048615"("embryonic anterior midgut (ectodermal) morphogenesis")|go:"GO:0048749"(compound eye development)|go:"GO:0048803"(imaginal disc-derived male genitalia morphogenesis)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061060"(negative regulation of peptidoglycan recognition protein signaling pathway)|go:"GO:0070303"(negative regulation of stress-activated protein kinase signaling cascade)|go:"GO:0071907"(determination of digestive tract left/right asymmetry)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|rcsb pdb:3HQL|reactome:R-DME-112409|reactome:R-DME-5675221 intact:EBI-132658(isoform-parent)|ensemblmetazoa:FBgn0264493(gene)|ensemblmetazoa:FBtr0301633(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/10 rogid:MrLidgQ1MAZdihyl2UY4kfvuUUY7227 rogid:wK8MgTf5GOHgmS5XgIMphs8z+oE7227 rigid:EbO05KkKVm+Fu2KTGrlsWzjfVcM false myc tag:n-n flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q6ZWS8 uniprotkb:Q0VGT2 intact:EBI-7128920|ensembl:ENSMUSP00000103350|ensembl:ENSMUSP00000103352|uniprotkb:Q3TLC2|uniprotkb:Q5ST07|intact:MINT-3982111|uniprotkb:Q76LV9 intact:EBI-9344284|uniprotkb:E9PYJ4|ensembl:ENSMUSP00000054837 psi-mi:spop_mouse(display_long)|uniprotkb:Spop(gene name)|psi-mi:Spop(display_short)|uniprotkb:Pcif1(gene name synonym)|uniprotkb:HIB homolog 1(gene name synonym)|uniprotkb:PDX-1 C-terminal-interacting factor 1(gene name synonym) psi-mi:gli2_mouse(display_long)|uniprotkb:Gli2(gene name)|psi-mi:Gli2(display_short)|uniprotkb:Thp(gene name synonym)|uniprotkb:Tax helper protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15818819|imex:IM-22463-19|dip:DIP-196195E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006532755.1|ensembl:ENSMUSG00000057522(gene)|ensembl:ENSMUST00000107722(transcript)|ensembl:ENSMUST00000107724(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR034089|mint:Q6ZWS8|reactome:R-MMU-5632684|refseq:NP_079563.2|dip:DIP-43930N refseq:NP_001074594.1|dip:DIP-60772N|ensembl:ENSMUSG00000048402(gene)|ensembl:ENSMUST00000062483(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007389"(pattern specification process)|go:"GO:0007411"(axon guidance)|go:"GO:0007418"(ventral midline development)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0021508"(floor plate formation)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021775"(smoothened signaling pathway involved in ventral spinal cord interneuron specification)|go:"GO:0021776"(smoothened signaling pathway involved in spinal cord motor neuron cell fate specification)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021915"(neural tube development)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030879"(mammary gland development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031514"(motile cilium)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0035295"(tube development)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048589"(developmental growth)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048856"(anatomical structure development)|go:"GO:0060032"(notochord regression)|go:"GO:0060322"(head development)|go:"GO:0060513"(prostatic bud formation)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097542"(ciliary tip)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901620"(regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|reactome:R-MMU-5610787|reactome:R-MMU-5632684 psi-mi:"MI:0465"(dip) comment:mint|function:Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex. In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3 - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/10 rogid:PC9ofpvk14xwTnnqT590/YRnx/410090 rogid:4rTCAbaXgbOsAHrJ9fhiPKh5ORQ10090 rigid:kV5YRtwIZ4hRArMr95yHvcgtOm0 false flag tag:n-n myc tag:n-n|sufficient binding region:620-1544 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZWS8 uniprotkb:Q0VGT2 intact:EBI-7128920|ensembl:ENSMUSP00000103350|ensembl:ENSMUSP00000103352|uniprotkb:Q3TLC2|uniprotkb:Q5ST07|intact:MINT-3982111|uniprotkb:Q76LV9 intact:EBI-9344284|uniprotkb:E9PYJ4|ensembl:ENSMUSP00000054837 psi-mi:spop_mouse(display_long)|uniprotkb:Spop(gene name)|psi-mi:Spop(display_short)|uniprotkb:Pcif1(gene name synonym)|uniprotkb:HIB homolog 1(gene name synonym)|uniprotkb:PDX-1 C-terminal-interacting factor 1(gene name synonym) psi-mi:gli2_mouse(display_long)|uniprotkb:Gli2(gene name)|psi-mi:Gli2(display_short)|uniprotkb:Thp(gene name synonym)|uniprotkb:Tax helper protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15818842|imex:IM-22463-20|dip:DIP-196195E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006532755.1|ensembl:ENSMUSG00000057522(gene)|ensembl:ENSMUST00000107722(transcript)|ensembl:ENSMUST00000107724(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR034089|mint:Q6ZWS8|reactome:R-MMU-5632684|refseq:NP_079563.2|dip:DIP-43930N refseq:NP_001074594.1|dip:DIP-60772N|ensembl:ENSMUSG00000048402(gene)|ensembl:ENSMUST00000062483(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007389"(pattern specification process)|go:"GO:0007411"(axon guidance)|go:"GO:0007418"(ventral midline development)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0021508"(floor plate formation)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021775"(smoothened signaling pathway involved in ventral spinal cord interneuron specification)|go:"GO:0021776"(smoothened signaling pathway involved in spinal cord motor neuron cell fate specification)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021915"(neural tube development)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030879"(mammary gland development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031514"(motile cilium)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0035295"(tube development)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048589"(developmental growth)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048856"(anatomical structure development)|go:"GO:0060032"(notochord regression)|go:"GO:0060322"(head development)|go:"GO:0060513"(prostatic bud formation)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097542"(ciliary tip)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901620"(regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|reactome:R-MMU-5610787|reactome:R-MMU-5632684 psi-mi:"MI:0465"(dip) comment:mint|function:Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex. In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3 - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/10 rogid:PC9ofpvk14xwTnnqT590/YRnx/410090 rogid:4rTCAbaXgbOsAHrJ9fhiPKh5ORQ10090 rigid:kV5YRtwIZ4hRArMr95yHvcgtOm0 false flag tag:n-n myc tag:n-n|sufficient binding region:620-1544 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P19538 uniprotkb:P19538 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15818865|imex:IM-22463-21|dip:DIP-45476E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/10 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rigid:M2kuvLtno9BZYhrmNoOjv03hmlI false myc tag:n-n ha tag:n-n|necessary binding region:1-620|sufficient binding region:441-1397 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P19538 uniprotkb:P19538 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15818890|imex:IM-22463-22|dip:DIP-45476E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/10 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rigid:M2kuvLtno9BZYhrmNoOjv03hmlI false myc tag:n-n ha tag:n-n|necessary binding region:1-620|sufficient binding region:441-1397 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9VFP2-2 uniprotkb:P19538 intact:EBI-15659276|ensemblmetazoa:FBpp0290847 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 psi-mi:q9vfp2-2(display_long)|uniprotkb:HIB(gene name synonym)|uniprotkb:Hh-induced MATH and BTB domain-containing protein(gene name synonym)|uniprotkb:CG12537(orf name)|uniprotkb:B(isoform synonym)|uniprotkb:rdx(gene name)|psi-mi:rdx(display_short) psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15818915|imex:IM-22463-23|dip:DIP-196192E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-132658(isoform-parent)|ensemblmetazoa:FBgn0264493(gene)|ensemblmetazoa:FBtr0301633(transcript) refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:wK8MgTf5GOHgmS5XgIMphs8z+oE7227 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rigid:l1DiCtexMnZJAtcN0KLPnImBiw8 false sufficient binding region:1-179 sufficient binding region:268-378|mutation disrupting interaction strength:369-369|mutation disrupting interaction strength:372-372|mutation disrupting interaction strength:373-373|mutation disrupting interaction strength:374-374|mutation disrupting interaction strength:375-375|mutation disrupting interaction strength:373-373|mutation disrupting interaction strength:374-374|mutation disrupting interaction strength:375-375 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9VFP2-2 uniprotkb:Q9VFP2-2 intact:EBI-15659276|ensemblmetazoa:FBpp0290847 intact:EBI-15659276|ensemblmetazoa:FBpp0290847 psi-mi:q9vfp2-2(display_long)|uniprotkb:HIB(gene name synonym)|uniprotkb:Hh-induced MATH and BTB domain-containing protein(gene name synonym)|uniprotkb:CG12537(orf name)|uniprotkb:B(isoform synonym)|uniprotkb:rdx(gene name)|psi-mi:rdx(display_short) psi-mi:q9vfp2-2(display_long)|uniprotkb:HIB(gene name synonym)|uniprotkb:Hh-induced MATH and BTB domain-containing protein(gene name synonym)|uniprotkb:CG12537(orf name)|uniprotkb:B(isoform synonym)|uniprotkb:rdx(gene name)|psi-mi:rdx(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15818960|imex:IM-22463-24|dip:DIP-196197E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-132658(isoform-parent)|ensemblmetazoa:FBgn0264493(gene)|ensemblmetazoa:FBtr0301633(transcript) intact:EBI-132658(isoform-parent)|ensemblmetazoa:FBgn0264493(gene)|ensemblmetazoa:FBtr0301633(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/10 rogid:wK8MgTf5GOHgmS5XgIMphs8z+oE7227 rogid:wK8MgTf5GOHgmS5XgIMphs8z+oE7227 rigid:uvxmCak2N97ftUs6D59wzboWNJA false flag tag:?-?|sufficient binding region:1-179 ha tag:?-?|sufficient binding region:1-179 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19538 uniprotkb:P19538 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:2364"(proximity) psi-mi:"MI:0465"(DIP) intact:EBI-15818989|imex:IM-22463-25|dip:DIP-45476E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/10 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rigid:M2kuvLtno9BZYhrmNoOjv03hmlI false yellow fluorescent protein tag:n-n cyan fluorescent protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZWS8 uniprotkb:P10071 intact:EBI-7128920|ensembl:ENSMUSP00000103350|ensembl:ENSMUSP00000103352|uniprotkb:Q3TLC2|uniprotkb:Q5ST07|intact:MINT-3982111|uniprotkb:Q76LV9 intact:EBI-308055|uniprotkb:A4D1W1|uniprotkb:O75219|uniprotkb:Q17RW4|uniprotkb:Q75MT0|uniprotkb:Q75MU9|uniprotkb:Q9UDT5|uniprotkb:Q9UJ39|ensembl:ENSP00000379258|ensembl:ENSP00000502957|ensembl:ENSP00000503743 psi-mi:spop_mouse(display_long)|uniprotkb:Spop(gene name)|psi-mi:Spop(display_short)|uniprotkb:Pcif1(gene name synonym)|uniprotkb:HIB homolog 1(gene name synonym)|uniprotkb:PDX-1 C-terminal-interacting factor 1(gene name synonym) psi-mi:gli3_human(display_long)|uniprotkb:GLI3(gene name)|psi-mi:GLI3(display_short)|uniprotkb:GLI3 full-length protein(gene name synonym)|uniprotkb:GLI3 form of 190 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2009) pubmed:19955409|doi:10.1073/pnas.0912008106|imex:IM-22463 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15819010|imex:IM-22463-26|dip:DIP-196196E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006532755.1|ensembl:ENSMUSG00000057522(gene)|ensembl:ENSMUST00000107722(transcript)|ensembl:ENSMUST00000107724(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR034089|mint:Q6ZWS8|reactome:R-MMU-5632684|refseq:NP_079563.2|dip:DIP-43930N refseq:NP_000159.3|ensembl:ENSG00000106571(gene)|ensembl:ENST00000395925(transcript)|ensembl:ENST00000677605(transcript)|ensembl:ENST00000678429(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0016485"(protein processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0021775"(smoothened signaling pathway involved in ventral spinal cord interneuron specification)|go:"GO:0021776"(smoothened signaling pathway involved in spinal cord motor neuron cell fate specification)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0022018"(lateral ganglionic eminence cell proliferation)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030850"(prostate gland development)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036033"(mediator complex binding)|go:"GO:0042060"(wound healing)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0060594"(mammary gland specification)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0060840"(artery development)|go:"GO:0060873"(anterior semicircular canal development)|go:"GO:0060875"(lateral semicircular canal development)|go:"GO:0061005"(cell differentiation involved in kidney development)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071625"(vocalization behavior)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:0120223"(larynx morphogenesis)|go:"GO:1901620"(regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043585"(nose morphogenesis)|go:"GO:0043586"(tongue development)|go:"GO:0043627"(response to estrogen)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045665"(negative regulation of neuron differentiation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR032851|interpro:IPR036236|interpro:IPR043359|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|mint:P10071|rcsb pdb:4BLD|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5632684|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|reactome:R-HSA-5635851|reactome:R-HSA-8940973|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048589"(developmental growth)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060364"(frontal suture morphogenesis)|go:"GO:0060366"(lambdoid suture morphogenesis)|go:"GO:0060367"(sagittal suture morphogenesis)|dip:DIP-32538N psi-mi:"MI:0465"(dip) comment:mint|function:Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex. In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3 - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/10 rogid:PC9ofpvk14xwTnnqT590/YRnx/410090 rogid:BOHGgIuKgq0gUSahFeRaKnRmoMs9606 rigid:PRrzR9OWToFqs95XhvnMiL1WNGw false flag tag:n-n myc tag:n-n|sufficient binding region:1-660 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)