#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P18901	uniprotkb:P61169	intact:EBI-15563390|uniprotkb:P21669	intact:EBI-80012|uniprotkb:P13953|ensembl:ENSRNOP00000043759	psi-mi:drd1_rat(display_long)|uniprotkb:Drd1(gene name)|psi-mi:Drd1(display_short)|uniprotkb:Drd1a(gene name synonym)|uniprotkb:Dopamine D1 receptor(gene name synonym)	psi-mi:drd2_rat(display_long)|uniprotkb:Drd2(gene name)|psi-mi:Drd2(display_short)|uniprotkb:Dopamine D2 receptor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hasbi et al. (2009)	pubmed:19948956|doi:10.1073/pnas.0903676106|imex:IM-14889	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15818019|imex:IM-14889-1|dip:DIP-104228E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001588"(dopamine neurotransmitter receptor activity, coupled via Gs)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0046323"(glucose import)|go:"GO:0046959"(habituation)|go:"GO:0046960"(sensitization)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0051117"(ATPase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071870"(cellular response to catecholamine stimulus)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099010"(modification of postsynaptic structure)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:2000253"(positive regulation of feeding behavior)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR001413(Dopamine 1A receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007617"(mating behavior)|go:"GO:0007625"(grooming behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005929"(cilium)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012505"(endomembrane system)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0014002"(astrocyte development)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0015872"(dopamine transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030432"(peristalsis)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031750"(D3 dopamine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035094"(response to nicotine)|go:"GO:0035106"(operant conditioning)|go:"GO:0035176"(social behavior)|go:"GO:0035240"(dopamine binding)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042311"(vasodilation)|go:"GO:0042321"(negative regulation of circadian sleep/wake cycle, sleep)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042755"(eating behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043200"(response to amino acid)|go:"GO:0043269"(regulation of ion transport)|go:"GO:0043278"(response to morphine)|go:"GO:0043679"(axon terminus)|go:"GO:0043987"(histone H3-S10 phosphorylation)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0032094"(response to food)|rgd:2518|dip:DIP-49024N	go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006914"(autophagy)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|ensembl:ENSRNOG00000008428(gene)|ensembl:ENSRNOT00000045944(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0007616"(long-term memory)|go:"GO:0007625"(grooming behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014854"(response to inactivity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0007416"(synapse assembly)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007409"(axonogenesis)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0060160"(negative regulation of dopamine receptor signaling pathway)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090325"(regulation of locomotion involved in locomotory behavior)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1990384"(hyaloid vascular plexus regression)|go:"GO:0035240"(dopamine binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042220"(response to cocaine)|go:"GO:0042321"(negative regulation of circadian sleep/wake cycle, sleep)|go:"GO:0045471"(response to ethanol)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|go:"GO:0042756"(drinking behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0043278"(response to morphine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043473"(pigmentation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030432"(peristalsis)|go:"GO:0030534"(adult behavior)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030900"(forebrain development)|go:"GO:0031223"(auditory behavior)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0034776"(response to histamine)|go:"GO:0035094"(response to nicotine)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0051584"(regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046717"(acid secretion)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048678"(response to axon injury)|go:"GO:0048755"(branching morphogenesis of a nerve)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR001922(Dopamine D2 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P61169|reactome:R-RNO-390651|rgd:2520|refseq:NP_036679.1|dip:DIP-30883N|refseq:XP_006243041.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/06	2017/08/10	rogid:vhBRmUdLUoVE+2pVaC1H8Zi28hw10116	rogid:wAMb1fnUAzjeTS2cQZaw6HRCcU010116	rigid:gkHxKOq+WuTbuLebsRUlVOC5CIo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)