#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q14157 uniprotkb:P21754 intact:EBI-347762|uniprotkb:Q5VU75|uniprotkb:Q5VU76|uniprotkb:Q9BTU3|uniprotkb:Q9UGL2|uniprotkb:Q9UGL3|uniprotkb:Q9UGL5|uniprotkb:B4E0U8|uniprotkb:Q9UGL4|ensembl:ENSP00000355343|ensembl:ENSP00000389445 intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326 psi-mi:ubp2l_human(display_long)|uniprotkb:UBAP2L(gene name)|psi-mi:UBAP2L(display_short)|uniprotkb:Protein NICE-4(gene name synonym)|uniprotkb:KIAA0144(gene name synonym)|uniprotkb:NICE4(gene name synonym) psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Naz et al. (2010) imex:IM-26202|pubmed:19945174 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16425901|imex:IM-26202-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011508518.1|refseq:NP_001120792.1|refseq:NP_055662.3|refseq:NP_001274744.1|refseq:NP_001274745.1|refseq:XP_005245731.1|refseq:XP_016858467.1|refseq:XP_016858468.1|refseq:XP_016858475.1|refseq:XP_016858476.1|refseq:XP_016858478.1|refseq:XP_016858479.1|ensembl:ENSG00000143569(gene)|ensembl:ENST00000361546(transcript)|ensembl:ENST00000428931(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0031519"(PcG protein complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|mint:Q14157 refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/09/21 2017/10/10 rogid:4iKY4hJOHGSyOOt8zfPhkeyth6Q9606 rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606 rigid:1hCk6m/Vb0E7d4/sgUI/QOyAItU false - sufficient binding region:104-424 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8IXA5 uniprotkb:P21754 intact:EBI-640732|uniprotkb:Q7Z4Y5|ensembl:ENSP00000269053 intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326 psi-mi:saca3_human(display_long)|uniprotkb:Sperm lysozyme-like protein 1(gene name synonym)|uniprotkb:Lysozyme-like protein 3(gene name synonym)|uniprotkb:Lysozyme-like acrosomal sperm-specific secretory protein ALLP-17(gene name synonym)|uniprotkb:Cancer/testis antigen 54(gene name synonym)|uniprotkb:SPACA3(gene name)|psi-mi:SPACA3(display_short)|uniprotkb:LYC3(gene name synonym)|uniprotkb:LYZL3(gene name synonym)|uniprotkb:SLLP1(gene name synonym)|uniprotkb:UNQ424/PRO862(orf name)|uniprotkb:SPRASA(gene name synonym)|uniprotkb:Sperm protein reactive with antisperm antibodies(gene name synonym) psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Naz et al. (2010) imex:IM-26202|pubmed:19945174 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16425908|imex:IM-26202-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_776246.1|refseq:NP_001304155.1|ensembl:ENSG00000141316(gene)|ensembl:ENST00000269053(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0005576"(extracellular region)|go:"GO:0007342"(fusion of sperm to egg plasma membrane involved in single fertilization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030141"(secretory granule)|go:"GO:0035036"(sperm-egg recognition)|go:"GO:0036126"(sperm flagellum)|go:"GO:0042117"(monocyte activation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043159"(acrosomal matrix)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR000974(Glycoside hydrolase, family 22, lysozyme)|interpro:IPR001916(Glycoside hydrolase, family 22)|interpro:IPR019799|interpro:IPR023346|interpro:IPR030058 refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Table 2-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/09/21 2017/10/10 rogid:6e2ehR7c2ANIcXYgv4/UiUpvqhI9606 rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606 rigid:MzrPr4aw7fmg8XrliLyEriTPcx4 false - sufficient binding region:104-424 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O14917 uniprotkb:P21754 intact:EBI-947061|uniprotkb:Q5VVW9|uniprotkb:Q5VVX0|uniprotkb:A8K1R5|ensembl:ENSP00000367151 intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326 psi-mi:pcd17_human(display_long)|uniprotkb:PCDH17(gene name)|psi-mi:PCDH17(display_short)|uniprotkb:PCDH68(gene name synonym)|uniprotkb:PCH68(gene name synonym)|uniprotkb:Protocadherin-68(gene name synonym) psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Naz et al. (2010) imex:IM-26202|pubmed:19945174 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16425914|imex:IM-26202-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035519.1|refseq:XP_005266414.1|go:"GO:1904071"(presynaptic active zone assembly)|go:"GO:2000807"(regulation of synaptic vesicle clustering)|interpro:IPR002126(Cadherin)|interpro:IPR013164(Cadherin, N-terminal)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR030709|rcsb pdb:6VFT|ensembl:ENSG00000118946(gene)|ensembl:ENST00000377918(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0030534"(adult behavior)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099560"(synaptic membrane adhesion) refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Table 2-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/09/21 2017/10/10 rogid:SsQ6UvnneZMuyX5PGul6AUJOVp49606 rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606 rigid:MVMM+7Ze3mvvtuegzXh9/9EN5r8 false - sufficient binding region:104-424 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8N3F8 uniprotkb:P21754 intact:EBI-1056885|uniprotkb:Q5TI16|uniprotkb:Q7RTP5|uniprotkb:Q8N3N8|uniprotkb:Q9BVL9|uniprotkb:Q9BY92|uniprotkb:Q9UH43|uniprotkb:Q9UH44|uniprotkb:Q9UH45|ensembl:ENSP00000215957 intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326 psi-mi:milk1_human(display_long)|uniprotkb:MICALL1(gene name)|psi-mi:MICALL1(display_short)|uniprotkb:KIAA1668(gene name synonym)|uniprotkb:MIRAB13(gene name synonym)|uniprotkb:Molecule interacting with Rab13(gene name synonym) psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Naz et al. (2010) imex:IM-26202|pubmed:19945174 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16425920|imex:IM-26202-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_203744.1|ensembl:ENSP00000215957|ensembl:ENSG00000100139(gene)|ensembl:ENST00000215957(transcript)|go:"GO:0005770"(late endosome)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032458"(slow endocytic recycling)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR022735|interpro:IPR028563|interpro:IPR036872|mint:Q8N3F8|rcsb pdb:2KSP|go:"GO:0045296"(cadherin binding) refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Table 2-4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/09/21 2017/10/10 rogid:G64P9EtjEfLIVLYkb+w3vCWaT0w9606 rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606 rigid:rBsIb64D8xPorAFsHN/Z6KimWwA false - sufficient binding region:104-424 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8N3F8 uniprotkb:P21754 intact:EBI-1056885|uniprotkb:Q5TI16|uniprotkb:Q7RTP5|uniprotkb:Q8N3N8|uniprotkb:Q9BVL9|uniprotkb:Q9BY92|uniprotkb:Q9UH43|uniprotkb:Q9UH44|uniprotkb:Q9UH45|ensembl:ENSP00000215957 intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326 psi-mi:milk1_human(display_long)|uniprotkb:MICALL1(gene name)|psi-mi:MICALL1(display_short)|uniprotkb:KIAA1668(gene name synonym)|uniprotkb:MIRAB13(gene name synonym)|uniprotkb:Molecule interacting with Rab13(gene name synonym) psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym) psi-mi:"MI:0728"(gal4 vp16 complementation) Naz et al. (2010) imex:IM-26202|pubmed:19945174 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16425938|imex:IM-26202-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_203744.1|ensembl:ENSP00000215957|ensembl:ENSG00000100139(gene)|ensembl:ENST00000215957(transcript)|go:"GO:0005770"(late endosome)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032458"(slow endocytic recycling)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR022735|interpro:IPR028563|interpro:IPR036872|mint:Q8N3F8|rcsb pdb:2KSP|go:"GO:0045296"(cadherin binding) refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:"Text above figure 6 (Table 2)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line) - 2017/09/21 2017/10/11 rogid:G64P9EtjEfLIVLYkb+w3vCWaT0w9606 rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606 rigid:rBsIb64D8xPorAFsHN/Z6KimWwA false - sufficient binding region:104-424 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IXA5 uniprotkb:P21754 intact:EBI-640732|uniprotkb:Q7Z4Y5|ensembl:ENSP00000269053 intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326 psi-mi:saca3_human(display_long)|uniprotkb:Sperm lysozyme-like protein 1(gene name synonym)|uniprotkb:Lysozyme-like protein 3(gene name synonym)|uniprotkb:Lysozyme-like acrosomal sperm-specific secretory protein ALLP-17(gene name synonym)|uniprotkb:Cancer/testis antigen 54(gene name synonym)|uniprotkb:SPACA3(gene name)|psi-mi:SPACA3(display_short)|uniprotkb:LYC3(gene name synonym)|uniprotkb:LYZL3(gene name synonym)|uniprotkb:SLLP1(gene name synonym)|uniprotkb:UNQ424/PRO862(orf name)|uniprotkb:SPRASA(gene name synonym)|uniprotkb:Sperm protein reactive with antisperm antibodies(gene name synonym) psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym) psi-mi:"MI:0728"(gal4 vp16 complementation) Naz et al. (2010) imex:IM-26202|pubmed:19945174 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16425950|imex:IM-26202-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_776246.1|refseq:NP_001304155.1|ensembl:ENSG00000141316(gene)|ensembl:ENST00000269053(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0005576"(extracellular region)|go:"GO:0007342"(fusion of sperm to egg plasma membrane involved in single fertilization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030141"(secretory granule)|go:"GO:0035036"(sperm-egg recognition)|go:"GO:0036126"(sperm flagellum)|go:"GO:0042117"(monocyte activation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043159"(acrosomal matrix)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR000974(Glycoside hydrolase, family 22, lysozyme)|interpro:IPR001916(Glycoside hydrolase, family 22)|interpro:IPR019799|interpro:IPR023346|interpro:IPR030058 refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:"Text above figure 6 (Table 2)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line) - 2017/09/21 2017/10/11 rogid:6e2ehR7c2ANIcXYgv4/UiUpvqhI9606 rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606 rigid:MzrPr4aw7fmg8XrliLyEriTPcx4 false - sufficient binding region:104-424 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14917 uniprotkb:P21754 intact:EBI-947061|uniprotkb:Q5VVW9|uniprotkb:Q5VVX0|uniprotkb:A8K1R5|ensembl:ENSP00000367151 intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326 psi-mi:pcd17_human(display_long)|uniprotkb:PCDH17(gene name)|psi-mi:PCDH17(display_short)|uniprotkb:PCDH68(gene name synonym)|uniprotkb:PCH68(gene name synonym)|uniprotkb:Protocadherin-68(gene name synonym) psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym) psi-mi:"MI:0728"(gal4 vp16 complementation) Naz et al. (2010) imex:IM-26202|pubmed:19945174 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16425956|imex:IM-26202-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035519.1|refseq:XP_005266414.1|go:"GO:1904071"(presynaptic active zone assembly)|go:"GO:2000807"(regulation of synaptic vesicle clustering)|interpro:IPR002126(Cadherin)|interpro:IPR013164(Cadherin, N-terminal)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR030709|rcsb pdb:6VFT|ensembl:ENSG00000118946(gene)|ensembl:ENST00000377918(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0030534"(adult behavior)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099560"(synaptic membrane adhesion) refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:"Text above figure 6 (Table 2)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line) - 2017/09/21 2017/10/11 rogid:SsQ6UvnneZMuyX5PGul6AUJOVp49606 rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606 rigid:MVMM+7Ze3mvvtuegzXh9/9EN5r8 false - sufficient binding region:104-424 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14157 uniprotkb:P21754 intact:EBI-347762|uniprotkb:Q5VU75|uniprotkb:Q5VU76|uniprotkb:Q9BTU3|uniprotkb:Q9UGL2|uniprotkb:Q9UGL3|uniprotkb:Q9UGL5|uniprotkb:B4E0U8|uniprotkb:Q9UGL4|ensembl:ENSP00000355343|ensembl:ENSP00000389445 intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326 psi-mi:ubp2l_human(display_long)|uniprotkb:UBAP2L(gene name)|psi-mi:UBAP2L(display_short)|uniprotkb:Protein NICE-4(gene name synonym)|uniprotkb:KIAA0144(gene name synonym)|uniprotkb:NICE4(gene name synonym) psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym) psi-mi:"MI:0728"(gal4 vp16 complementation) Naz et al. (2010) imex:IM-26202|pubmed:19945174 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16425944|imex:IM-26202-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011508518.1|refseq:NP_001120792.1|refseq:NP_055662.3|refseq:NP_001274744.1|refseq:NP_001274745.1|refseq:XP_005245731.1|refseq:XP_016858467.1|refseq:XP_016858468.1|refseq:XP_016858475.1|refseq:XP_016858476.1|refseq:XP_016858478.1|refseq:XP_016858479.1|ensembl:ENSG00000143569(gene)|ensembl:ENST00000361546(transcript)|ensembl:ENST00000428931(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0031519"(PcG protein complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|mint:Q14157 refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:"Text above figure 6 (Table 2)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line) - 2017/09/21 2017/10/11 rogid:4iKY4hJOHGSyOOt8zfPhkeyth6Q9606 rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606 rigid:1hCk6m/Vb0E7d4/sgUI/QOyAItU false - sufficient binding region:104-424 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)