#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P84228 uniprotkb:Q8TF76-1 intact:EBI-2658213|uniprotkb:A3KMN6|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:P17320|uniprotkb:Q60582|uniprotkb:Q78E59|uniprotkb:Q8CGN9|ensembl:ENSMUSP00000074994|ensembl:ENSMUSP00000089295|ensembl:ENSMUSP00000089346|ensembl:ENSMUSP00000096442|ensembl:ENSMUSP00000100737|ensembl:ENSMUSP00000100739|ensembl:ENSMUSP00000134751|ensembl:ENSMUSP00000135215 intact:EBI-15815652|ensembl:ENSP00000325290 psi-mi:h32_mouse(display_long)|uniprotkb:H3c13(gene name)|psi-mi:H3c13(display_short)|uniprotkb:H3c14(gene name)|psi-mi:H3c14(display_short)|uniprotkb:H3c15(gene name)|psi-mi:H3c15(display_short)|uniprotkb:H3c2(gene name)|psi-mi:H3c2(display_short)|uniprotkb:H3c3(gene name)|psi-mi:H3c3(display_short)|uniprotkb:H3c4(gene name)|psi-mi:H3c4(display_short)|uniprotkb:H3c6(gene name)|psi-mi:H3c6(display_short)|uniprotkb:H3c7(gene name)|psi-mi:H3c7(display_short)|uniprotkb:H3-143(gene name synonym)|uniprotkb:H3-53(gene name synonym)|uniprotkb:H3-B(gene name synonym)|uniprotkb:H3-F(gene name synonym)|uniprotkb:H3-clustered histone 13(gene name synonym)|uniprotkb:H3-clustered histone 14(gene name synonym)|uniprotkb:H3-clustered histone 15(gene name synonym)|uniprotkb:H3-clustered histone 2(gene name synonym)|uniprotkb:H3-clustered histone 3(gene name synonym)|uniprotkb:H3-clustered histone 4(gene name synonym)|uniprotkb:H3-clustered histone 6(gene name synonym)|uniprotkb:H3-clustered histone 7(gene name synonym)|uniprotkb:H3.2(gene name synonym)|uniprotkb:H3.2-221(gene name synonym)|uniprotkb:H3.2-614(gene name synonym)|uniprotkb:H3.2-615(gene name synonym)|uniprotkb:H3.2-616(gene name synonym)|uniprotkb:H3b(gene name synonym)|uniprotkb:H3f(gene name synonym)|uniprotkb:Hist1h3b(gene name synonym)|uniprotkb:Hist1h3c(gene name synonym)|uniprotkb:Hist1h3d(gene name synonym)|uniprotkb:Hist1h3e(gene name synonym)|uniprotkb:Hist1h3f(gene name synonym)|uniprotkb:Hist2h3b(gene name synonym)|uniprotkb:Hist2h3c1(gene name synonym)|uniprotkb:Hist2h3c2(gene name synonym)|uniprotkb:Hist2h3ca1(gene name synonym)|uniprotkb:Hist2h3ca2(gene name synonym) psi-mi:q8tf76-1(display_long)|uniprotkb:HASPIN(gene name)|psi-mi:HASPIN(display_short)|uniprotkb:GSG2(gene name synonym)|uniprotkb:Germ cell-specific gene 2 protein(gene name synonym)|uniprotkb:H-haspin(gene name synonym)|uniprotkb:Haploid germ cell-specific nuclear protein kinase(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Villa et al. (2009) pubmed:19918049|doi:10.1073/pnas.0908485106|imex:IM-14882 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15815661|imex:IM-14882-1|dip:DIP-104206E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038576.1|refseq:NP_473386.1|refseq:NP_783584.1|refseq:NP_835510.1|refseq:NP_835511.1|refseq:NP_835512.1|refseq:NP_835587.1|refseq:NP_835734.2|ensembl:ENSMUSG00000069267(gene)|ensembl:ENSMUSG00000069273(gene)|ensembl:ENSMUSG00000069310(gene)|ensembl:ENSMUSG00000074403(gene)|ensembl:ENSMUSG00000081058(gene)|ensembl:ENSMUSG00000093769(gene)|ensembl:ENSMUSG00000099583(gene)|ensembl:ENSMUSG00000100210(gene)|ensembl:ENSMUST00000075558(transcript)|ensembl:ENSMUST00000091703(transcript)|ensembl:ENSMUST00000091752(transcript)|ensembl:ENSMUST00000098843(transcript)|ensembl:ENSMUST00000105105(transcript)|ensembl:ENSMUST00000105107(transcript)|ensembl:ENSMUST00000167403(transcript)|ensembl:ENSMUST00000176059(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|interpro:IPR009072(Histone-fold)|mint:P84228|rcsb pdb:2V86|go:"GO:0003682"(chromatin binding)|rcsb pdb:2V87|rcsb pdb:2V88|rcsb pdb:4QWN|rcsb pdb:4QX7|go:"GO:0005634"(nucleus)|rcsb pdb:4QX8|rcsb pdb:4QXB|rcsb pdb:4QXC|rcsb pdb:4QXH|reactome:R-MMU-1266695|reactome:R-MMU-212300|go:"GO:0005654"(nucleoplasm)|reactome:R-MMU-2559580|go:"GO:0006334"(nucleosome assembly)|reactome:R-MMU-2559582|reactome:R-MMU-3214815|reactome:R-MMU-3214841|reactome:R-MMU-3214842|reactome:R-MMU-3214847|reactome:R-MMU-3214858|reactome:R-MMU-3247509|reactome:R-MMU-427359|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|reactome:R-MMU-427413|reactome:R-MMU-5250924|go:"GO:0032991"(protein-containing complex)|go:"GO:0046982"(protein heterodimerization activity)|reactome:R-MMU-5578749|go:"GO:0060968"(obsolete regulation of gene silencing)|reactome:R-MMU-5625886|reactome:R-MMU-73728|reactome:R-MMU-73772|reactome:R-MMU-8936459|interpro:IPR000164(Histone H3)|reactome:R-MMU-9018519|interpro:IPR007125(Histone core)|reactome:R-MMU-983231|dip:DIP-49015N intact:EBI-1237328(isoform-parent)|ensembl:ENSG00000177602(gene)|ensembl:ENST00000325418(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o10090 rogid:oEsn4Mdj1ffEam0s7mvekInDHO49606 rigid:lhw5QtMGNesZXDt2cbAyRv1r+vs false binding-associated region:1-50 binding-associated region:452-798|mutation decreasing interaction:492-492|mutation decreasing interaction:651-651|mutation decreasing interaction:707-707|mutation decreasing interaction:709-709|mutation decreasing interaction:713-713 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P84228 uniprotkb:Q8TF76-1 intact:EBI-2658213|uniprotkb:A3KMN6|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:P17320|uniprotkb:Q60582|uniprotkb:Q78E59|uniprotkb:Q8CGN9|ensembl:ENSMUSP00000074994|ensembl:ENSMUSP00000089295|ensembl:ENSMUSP00000089346|ensembl:ENSMUSP00000096442|ensembl:ENSMUSP00000100737|ensembl:ENSMUSP00000100739|ensembl:ENSMUSP00000134751|ensembl:ENSMUSP00000135215 intact:EBI-15815652|ensembl:ENSP00000325290 psi-mi:h32_mouse(display_long)|uniprotkb:H3c13(gene name)|psi-mi:H3c13(display_short)|uniprotkb:H3c14(gene name)|psi-mi:H3c14(display_short)|uniprotkb:H3c15(gene name)|psi-mi:H3c15(display_short)|uniprotkb:H3c2(gene name)|psi-mi:H3c2(display_short)|uniprotkb:H3c3(gene name)|psi-mi:H3c3(display_short)|uniprotkb:H3c4(gene name)|psi-mi:H3c4(display_short)|uniprotkb:H3c6(gene name)|psi-mi:H3c6(display_short)|uniprotkb:H3c7(gene name)|psi-mi:H3c7(display_short)|uniprotkb:H3-143(gene name synonym)|uniprotkb:H3-53(gene name synonym)|uniprotkb:H3-B(gene name synonym)|uniprotkb:H3-F(gene name synonym)|uniprotkb:H3-clustered histone 13(gene name synonym)|uniprotkb:H3-clustered histone 14(gene name synonym)|uniprotkb:H3-clustered histone 15(gene name synonym)|uniprotkb:H3-clustered histone 2(gene name synonym)|uniprotkb:H3-clustered histone 3(gene name synonym)|uniprotkb:H3-clustered histone 4(gene name synonym)|uniprotkb:H3-clustered histone 6(gene name synonym)|uniprotkb:H3-clustered histone 7(gene name synonym)|uniprotkb:H3.2(gene name synonym)|uniprotkb:H3.2-221(gene name synonym)|uniprotkb:H3.2-614(gene name synonym)|uniprotkb:H3.2-615(gene name synonym)|uniprotkb:H3.2-616(gene name synonym)|uniprotkb:H3b(gene name synonym)|uniprotkb:H3f(gene name synonym)|uniprotkb:Hist1h3b(gene name synonym)|uniprotkb:Hist1h3c(gene name synonym)|uniprotkb:Hist1h3d(gene name synonym)|uniprotkb:Hist1h3e(gene name synonym)|uniprotkb:Hist1h3f(gene name synonym)|uniprotkb:Hist2h3b(gene name synonym)|uniprotkb:Hist2h3c1(gene name synonym)|uniprotkb:Hist2h3c2(gene name synonym)|uniprotkb:Hist2h3ca1(gene name synonym)|uniprotkb:Hist2h3ca2(gene name synonym) psi-mi:q8tf76-1(display_long)|uniprotkb:HASPIN(gene name)|psi-mi:HASPIN(display_short)|uniprotkb:GSG2(gene name synonym)|uniprotkb:Germ cell-specific gene 2 protein(gene name synonym)|uniprotkb:H-haspin(gene name synonym)|uniprotkb:Haploid germ cell-specific nuclear protein kinase(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Villa et al. (2009) pubmed:19918049|doi:10.1073/pnas.0908485106|imex:IM-14882 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0465"(DIP) intact:EBI-15815697|imex:IM-14882-2|dip:DIP-104206E - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038576.1|refseq:NP_473386.1|refseq:NP_783584.1|refseq:NP_835510.1|refseq:NP_835511.1|refseq:NP_835512.1|refseq:NP_835587.1|refseq:NP_835734.2|ensembl:ENSMUSG00000069267(gene)|ensembl:ENSMUSG00000069273(gene)|ensembl:ENSMUSG00000069310(gene)|ensembl:ENSMUSG00000074403(gene)|ensembl:ENSMUSG00000081058(gene)|ensembl:ENSMUSG00000093769(gene)|ensembl:ENSMUSG00000099583(gene)|ensembl:ENSMUSG00000100210(gene)|ensembl:ENSMUST00000075558(transcript)|ensembl:ENSMUST00000091703(transcript)|ensembl:ENSMUST00000091752(transcript)|ensembl:ENSMUST00000098843(transcript)|ensembl:ENSMUST00000105105(transcript)|ensembl:ENSMUST00000105107(transcript)|ensembl:ENSMUST00000167403(transcript)|ensembl:ENSMUST00000176059(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|interpro:IPR009072(Histone-fold)|mint:P84228|rcsb pdb:2V86|go:"GO:0003682"(chromatin binding)|rcsb pdb:2V87|rcsb pdb:2V88|rcsb pdb:4QWN|rcsb pdb:4QX7|go:"GO:0005634"(nucleus)|rcsb pdb:4QX8|rcsb pdb:4QXB|rcsb pdb:4QXC|rcsb pdb:4QXH|reactome:R-MMU-1266695|reactome:R-MMU-212300|go:"GO:0005654"(nucleoplasm)|reactome:R-MMU-2559580|go:"GO:0006334"(nucleosome assembly)|reactome:R-MMU-2559582|reactome:R-MMU-3214815|reactome:R-MMU-3214841|reactome:R-MMU-3214842|reactome:R-MMU-3214847|reactome:R-MMU-3214858|reactome:R-MMU-3247509|reactome:R-MMU-427359|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|reactome:R-MMU-427413|reactome:R-MMU-5250924|go:"GO:0032991"(protein-containing complex)|go:"GO:0046982"(protein heterodimerization activity)|reactome:R-MMU-5578749|go:"GO:0060968"(obsolete regulation of gene silencing)|reactome:R-MMU-5625886|reactome:R-MMU-73728|reactome:R-MMU-73772|reactome:R-MMU-8936459|interpro:IPR000164(Histone H3)|reactome:R-MMU-9018519|interpro:IPR007125(Histone core)|reactome:R-MMU-983231|dip:DIP-49015N intact:EBI-1237328(isoform-parent)|ensembl:ENSG00000177602(gene)|ensembl:ENST00000325418(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o10090 rogid:oEsn4Mdj1ffEam0s7mvekInDHO49606 rigid:lhw5QtMGNesZXDt2cbAyRv1r+vs false binding-associated region:1-50|O-phospho-L-threonine:4-4 binding-associated region:452-798 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q8TF76-1 uniprotkb:P84228 intact:EBI-15815652|ensembl:ENSP00000325290 intact:EBI-2658213|uniprotkb:A3KMN6|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:P17320|uniprotkb:Q60582|uniprotkb:Q78E59|uniprotkb:Q8CGN9|ensembl:ENSMUSP00000074994|ensembl:ENSMUSP00000089295|ensembl:ENSMUSP00000089346|ensembl:ENSMUSP00000096442|ensembl:ENSMUSP00000100737|ensembl:ENSMUSP00000100739|ensembl:ENSMUSP00000134751|ensembl:ENSMUSP00000135215 psi-mi:q8tf76-1(display_long)|uniprotkb:HASPIN(gene name)|psi-mi:HASPIN(display_short)|uniprotkb:GSG2(gene name synonym)|uniprotkb:Germ cell-specific gene 2 protein(gene name synonym)|uniprotkb:H-haspin(gene name synonym)|uniprotkb:Haploid germ cell-specific nuclear protein kinase(gene name synonym) psi-mi:h32_mouse(display_long)|uniprotkb:H3c13(gene name)|psi-mi:H3c13(display_short)|uniprotkb:H3c14(gene name)|psi-mi:H3c14(display_short)|uniprotkb:H3c15(gene name)|psi-mi:H3c15(display_short)|uniprotkb:H3c2(gene name)|psi-mi:H3c2(display_short)|uniprotkb:H3c3(gene name)|psi-mi:H3c3(display_short)|uniprotkb:H3c4(gene name)|psi-mi:H3c4(display_short)|uniprotkb:H3c6(gene name)|psi-mi:H3c6(display_short)|uniprotkb:H3c7(gene name)|psi-mi:H3c7(display_short)|uniprotkb:H3-143(gene name synonym)|uniprotkb:H3-53(gene name synonym)|uniprotkb:H3-B(gene name synonym)|uniprotkb:H3-F(gene name synonym)|uniprotkb:H3-clustered histone 13(gene name synonym)|uniprotkb:H3-clustered histone 14(gene name synonym)|uniprotkb:H3-clustered histone 15(gene name synonym)|uniprotkb:H3-clustered histone 2(gene name synonym)|uniprotkb:H3-clustered histone 3(gene name synonym)|uniprotkb:H3-clustered histone 4(gene name synonym)|uniprotkb:H3-clustered histone 6(gene name synonym)|uniprotkb:H3-clustered histone 7(gene name synonym)|uniprotkb:H3.2(gene name synonym)|uniprotkb:H3.2-221(gene name synonym)|uniprotkb:H3.2-614(gene name synonym)|uniprotkb:H3.2-615(gene name synonym)|uniprotkb:H3.2-616(gene name synonym)|uniprotkb:H3b(gene name synonym)|uniprotkb:H3f(gene name synonym)|uniprotkb:Hist1h3b(gene name synonym)|uniprotkb:Hist1h3c(gene name synonym)|uniprotkb:Hist1h3d(gene name synonym)|uniprotkb:Hist1h3e(gene name synonym)|uniprotkb:Hist1h3f(gene name synonym)|uniprotkb:Hist2h3b(gene name synonym)|uniprotkb:Hist2h3c1(gene name synonym)|uniprotkb:Hist2h3c2(gene name synonym)|uniprotkb:Hist2h3ca1(gene name synonym)|uniprotkb:Hist2h3ca2(gene name synonym) psi-mi:"MI:0096"(pull down) Villa et al. (2009) pubmed:19918049|doi:10.1073/pnas.0908485106|imex:IM-14882 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15815720|imex:IM-14882-3|dip:DIP-104206E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1237328(isoform-parent)|ensembl:ENSG00000177602(gene)|ensembl:ENST00000325418(transcript) refseq:NP_038576.1|refseq:NP_473386.1|refseq:NP_783584.1|refseq:NP_835510.1|refseq:NP_835511.1|refseq:NP_835512.1|refseq:NP_835587.1|refseq:NP_835734.2|ensembl:ENSMUSG00000069267(gene)|ensembl:ENSMUSG00000069273(gene)|ensembl:ENSMUSG00000069310(gene)|ensembl:ENSMUSG00000074403(gene)|ensembl:ENSMUSG00000081058(gene)|ensembl:ENSMUSG00000093769(gene)|ensembl:ENSMUSG00000099583(gene)|ensembl:ENSMUSG00000100210(gene)|ensembl:ENSMUST00000075558(transcript)|ensembl:ENSMUST00000091703(transcript)|ensembl:ENSMUST00000091752(transcript)|ensembl:ENSMUST00000098843(transcript)|ensembl:ENSMUST00000105105(transcript)|ensembl:ENSMUST00000105107(transcript)|ensembl:ENSMUST00000167403(transcript)|ensembl:ENSMUST00000176059(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|interpro:IPR009072(Histone-fold)|mint:P84228|rcsb pdb:2V86|go:"GO:0003682"(chromatin binding)|rcsb pdb:2V87|rcsb pdb:2V88|rcsb pdb:4QWN|rcsb pdb:4QX7|go:"GO:0005634"(nucleus)|rcsb pdb:4QX8|rcsb pdb:4QXB|rcsb pdb:4QXC|rcsb pdb:4QXH|reactome:R-MMU-1266695|reactome:R-MMU-212300|go:"GO:0005654"(nucleoplasm)|reactome:R-MMU-2559580|go:"GO:0006334"(nucleosome assembly)|reactome:R-MMU-2559582|reactome:R-MMU-3214815|reactome:R-MMU-3214841|reactome:R-MMU-3214842|reactome:R-MMU-3214847|reactome:R-MMU-3214858|reactome:R-MMU-3247509|reactome:R-MMU-427359|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|reactome:R-MMU-427413|reactome:R-MMU-5250924|go:"GO:0032991"(protein-containing complex)|go:"GO:0046982"(protein heterodimerization activity)|reactome:R-MMU-5578749|go:"GO:0060968"(obsolete regulation of gene silencing)|reactome:R-MMU-5625886|reactome:R-MMU-73728|reactome:R-MMU-73772|reactome:R-MMU-8936459|interpro:IPR000164(Histone H3)|reactome:R-MMU-9018519|interpro:IPR007125(Histone core)|reactome:R-MMU-983231|dip:DIP-49015N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:oEsn4Mdj1ffEam0s7mvekInDHO49606 rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o10090 rigid:lhw5QtMGNesZXDt2cbAyRv1r+vs false binding-associated region:452-798 binding-associated region:1-30|glutathione s tranferase tag:c-c - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)