#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P70671	uniprotkb:P70671	intact:EBI-7947049|intact:MINT-2737174|ensembl:ENSMUSP00000003284|ensembl:ENSMUSP00000103465|ensembl:ENSMUSP00000146773	intact:EBI-7947049|intact:MINT-2737174|ensembl:ENSMUSP00000003284|ensembl:ENSMUSP00000103465|ensembl:ENSMUSP00000146773	psi-mi:irf3_mouse(display_long)|uniprotkb:Irf3(gene name)|psi-mi:Irf3(display_short)	psi-mi:irf3_mouse(display_long)|uniprotkb:Irf3(gene name)|psi-mi:Irf3(display_short)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Yanai et al. (2009)	pubmed:19890330|doi:10.1038/nature08512|imex:IM-16365	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15813227|imex:IM-16365-1|dip:DIP-185612E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058545.1|refseq:XP_006541058.1|refseq:XP_006541059.1|dip:DIP-29881N|ensembl:ENSMUSG00000003184(gene)|ensembl:ENSMUST00000003284(transcript)|ensembl:ENSMUST00000107834(transcript)|ensembl:ENSMUST00000209066(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002376"(immune system process)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009617"(response to bacterium)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|mint:P70671|rcsb pdb:7JFM|reactome:R-MMU-1169408|reactome:R-MMU-1606341|reactome:R-MMU-168928|reactome:R-MMU-3134973|reactome:R-MMU-3134975|reactome:R-MMU-3270619|reactome:R-MMU-9013973|reactome:R-MMU-918233|reactome:R-MMU-933541|reactome:R-MMU-936440|reactome:R-MMU-936964|interpro:IPR036390	refseq:NP_058545.1|refseq:XP_006541058.1|refseq:XP_006541059.1|dip:DIP-29881N|ensembl:ENSMUSG00000003184(gene)|ensembl:ENSMUST00000003284(transcript)|ensembl:ENSMUST00000107834(transcript)|ensembl:ENSMUST00000209066(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002376"(immune system process)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009617"(response to bacterium)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|mint:P70671|rcsb pdb:7JFM|reactome:R-MMU-1169408|reactome:R-MMU-1606341|reactome:R-MMU-168928|reactome:R-MMU-3134973|reactome:R-MMU-3134975|reactome:R-MMU-3270619|reactome:R-MMU-9013973|reactome:R-MMU-918233|reactome:R-MMU-933541|reactome:R-MMU-936440|reactome:R-MMU-936964|interpro:IPR036390	psi-mi:"MI:0465"(dip)	comment:mint|comment:homomint|function:"Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains"	comment:mint|comment:homomint|function:"Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:xmGnU7D+q5tJfXGdJWnPOZHdD4I10090	rogid:xmGnU7D+q5tJfXGdJWnPOZHdD4I10090	rigid:LVFRY/PBowrXN+kSdbUFS/OtAno	false	-	-	-	0	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)