#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P16621 uniprotkb:P16621 intact:EBI-668630|uniprotkb:Q960M3|uniprotkb:Q9VIS8|ensemblmetazoa:FBpp0080801 intact:EBI-668630|uniprotkb:Q960M3|uniprotkb:Q9VIS8|ensemblmetazoa:FBpp0080801 psi-mi:lar_drome(display_long)|uniprotkb:Protein-tyrosine-phosphate phosphohydrolase(gene name synonym)|uniprotkb:dLAR(gene name synonym)|uniprotkb:Lar(gene name)|psi-mi:Lar(display_short)|uniprotkb:CG10443(orf name) psi-mi:lar_drome(display_long)|uniprotkb:Protein-tyrosine-phosphate phosphohydrolase(gene name synonym)|uniprotkb:dLAR(gene name synonym)|uniprotkb:Lar(gene name)|psi-mi:Lar(display_short)|uniprotkb:CG10443(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Hofmeyer et al. (2009) pubmed:19889974|doi:10.1073/pnas.0903961106|imex:IM-14873 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15812875|imex:IM-14873-1|dip:DIP-104192E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_523604.2|flybase:FBgn0000464|dip:DIP-38648N|ensemblmetazoa:FBgn0000464(gene)|ensemblmetazoa:FBtr0081260(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007412"(axon target recognition)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031252"(cell leading edge)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032093"(SAM domain binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0045467"(R7 cell development)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048675"(axon extension)|go:"GO:0048841"(regulation of axon extension involved in axon guidance)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060269"(centripetally migrating follicle cell migration)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:0120034"(positive regulation of plasma membrane bounded cell projection assembly)|go:"GO:1903386"(negative regulation of homophilic cell adhesion)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2YD1|rcsb pdb:3PXJ|rcsb pdb:6X38|reactome:R-DME-388844|reactome:R-DME-8849932 refseq:NP_523604.2|flybase:FBgn0000464|dip:DIP-38648N|ensemblmetazoa:FBgn0000464(gene)|ensemblmetazoa:FBtr0081260(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007412"(axon target recognition)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031252"(cell leading edge)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032093"(SAM domain binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0045467"(R7 cell development)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048675"(axon extension)|go:"GO:0048841"(regulation of axon extension involved in axon guidance)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060269"(centripetally migrating follicle cell migration)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:0120034"(positive regulation of plasma membrane bounded cell projection assembly)|go:"GO:1903386"(negative regulation of homophilic cell adhesion)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2YD1|rcsb pdb:3PXJ|rcsb pdb:6X38|reactome:R-DME-388844|reactome:R-DME-8849932 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/06 2017/08/10 rogid:rFF+oNmRMa0r6iVk4/gea7ozJfE7227 rogid:rFF+oNmRMa0r6iVk4/gea7ozJfE7227 rigid:mW34Esrnb2z3KlN6+MtaL4+t19M false binding-associated region:1-1810|ha tag:n-n|mutation disrupting interaction:1453-1453,1452-1452 binding-associated region:1415-2029|myc tag:n-n|mutation disrupting interaction:1453-1453,1452-1452 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)