#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q62824 uniprotkb:Q66H76 intact:EBI-6959516|intact:MINT-87397 intact:EBI-15812499|ensembl:ENSRNOP00000043928 psi-mi:exoc4_rat(display_long)|uniprotkb:Exoc4(gene name)|psi-mi:Exoc4(display_short)|uniprotkb:Sec8(gene name synonym)|uniprotkb:Sec8l1(gene name synonym)|uniprotkb:Exocyst complex component Sec8(gene name synonym) psi-mi:paxi_rat(display_long)|uniprotkb:Pxn(gene name)|psi-mi:Pxn(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Rosse et al. (2009) pubmed:19885391|doi:10.1371/journal.pbio.1000235|imex:IM-14171 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15812534|imex:IM-14171-2|dip:DIP-102880E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043209"(myelin sheath)|go:"GO:0044091"(membrane biogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055108"(Golgi to transport vesicle transport)|go:"GO:0090522"(vesicle tethering involved in exocytosis)|go:"GO:0090543"(Flemming body)|interpro:IPR007191(Sec8 exocyst complex component specific domain)|interpro:IPR039682|go:"GO:0032584"(growth cone membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0000145"(exocyst)|go:"GO:0005902"(microvillus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006904"(vesicle docking involved in exocytosis)|reactome:R-RNO-264876|refseq:NP_446327.1|rgd:621791|dip:DIP-40985N|reactome:R-RNO-5620916 ensembl:ENSRNOG00000001149(gene)|ensembl:ENSRNOT00000047466(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001725"(stress fiber)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0017166"(vinculin binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0038191"(neuropilin binding)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051435"(BH4 domain binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:1901652"(response to peptide)|interpro:IPR001781(Zinc finger, LIM-type)|go:"GO:0008360"(regulation of cell shape)|interpro:IPR001904(Paxillin)|interpro:IPR017305(Leupaxin)|reactome:R-RNO-180292|reactome:R-RNO-4420097|reactome:R-RNO-445355|reactome:R-RNO-446343|reactome:R-RNO-446388|reactome:R-RNO-8849471|refseq:NP_001012147.1|rgd:1305759|dip:DIP-48423N psi-mi:"MI:0465"(dip) function:Component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane|comment:mint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2017/08/06 2017/08/10 rogid:+UaPRKfrnwMX9fQS6BS63c8dh2E10116 rogid:Rz2iVX19FJcMNDdGZHaEIe4M41k10116 rigid:wRnCSiOZYHnBcI0LEgRM4ZBniSM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q62824 uniprotkb:Q8IX03-1 intact:EBI-6959516|intact:MINT-87397 intact:EBI-15812469|ensembl:ENSP00000265293 psi-mi:exoc4_rat(display_long)|uniprotkb:Exoc4(gene name)|psi-mi:Exoc4(display_short)|uniprotkb:Sec8(gene name synonym)|uniprotkb:Sec8l1(gene name synonym)|uniprotkb:Exocyst complex component Sec8(gene name synonym) psi-mi:q8ix03-1(display_long)|uniprotkb:WWC1(gene name)|psi-mi:WWC1(display_short)|uniprotkb:KIAA0869(gene name synonym)|uniprotkb:HBeAg-binding protein 3(gene name synonym)|uniprotkb:Kidney and brain protein(gene name synonym)|uniprotkb:WW domain-containing protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Rosse et al. (2009) pubmed:19885391|doi:10.1371/journal.pbio.1000235|imex:IM-14171 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15812480|imex:IM-14171-1|dip:DIP-102883E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043209"(myelin sheath)|go:"GO:0044091"(membrane biogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055108"(Golgi to transport vesicle transport)|go:"GO:0090522"(vesicle tethering involved in exocytosis)|go:"GO:0090543"(Flemming body)|interpro:IPR007191(Sec8 exocyst complex component specific domain)|interpro:IPR039682|go:"GO:0032584"(growth cone membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0000145"(exocyst)|go:"GO:0005902"(microvillus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006904"(vesicle docking involved in exocytosis)|reactome:R-RNO-264876|refseq:NP_446327.1|rgd:621791|dip:DIP-40985N|reactome:R-RNO-5620916 ensembl:ENSG00000113645(gene)|ensembl:ENST00000265293(transcript)|intact:EBI-715828(isoform-parent) psi-mi:"MI:0465"(dip) function:Component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane|comment:mint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2017/08/06 2017/08/10 rogid:+UaPRKfrnwMX9fQS6BS63c8dh2E10116 rogid:AGllK9/JguvRQEPw79FYfSgPjiU9606 rigid:4jGpQjiKKYhZTCH+lN0Sw3A7dEA false - myc tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8IX03-1 uniprotkb:Q9NV70 intact:EBI-15812469|ensembl:ENSP00000265293 intact:EBI-1045313|uniprotkb:Q504V4|uniprotkb:Q8WUE7|uniprotkb:Q96T15|uniprotkb:Q9NZE4|ensembl:ENSP00000326514|ensembl:ENSP00000370695 psi-mi:q8ix03-1(display_long)|uniprotkb:WWC1(gene name)|psi-mi:WWC1(display_short)|uniprotkb:KIAA0869(gene name synonym)|uniprotkb:HBeAg-binding protein 3(gene name synonym)|uniprotkb:Kidney and brain protein(gene name synonym)|uniprotkb:WW domain-containing protein 1(gene name synonym) psi-mi:exoc1_human(display_long)|uniprotkb:Exocyst complex component Sec3(gene name synonym)|uniprotkb:EXOC1(gene name)|psi-mi:EXOC1(display_short)|uniprotkb:SEC3(gene name synonym)|uniprotkb:SEC3L1(gene name synonym)|uniprotkb:BM-012(orf name) psi-mi:"MI:0018"(two hybrid) Rosse et al. (2009) pubmed:19885391|doi:10.1371/journal.pbio.1000235|imex:IM-14171 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15812551|imex:IM-14171-3|dip:DIP-102885E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113645(gene)|ensembl:ENST00000265293(transcript)|intact:EBI-715828(isoform-parent) refseq:NP_001020095.1|refseq:NP_060731.2|refseq:NP_839955.1|ensembl:ENSG00000090989(gene)|ensembl:ENST00000346134(transcript)|ensembl:ENST00000381295(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051607"(defense response to virus)|go:"GO:0090543"(Flemming body)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|interpro:IPR019160|interpro:IPR028258|mint:Q9NV70|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|refseq:XP_016863898.1|dip:DIP-37579N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:AGllK9/JguvRQEPw79FYfSgPjiU9606 rogid:DKEfnn4CJkBSIdGRfVy+znSPOrc9606 rigid:7AzMYrA55bsKwA5DgoDYQXUIduM false sufficient binding region:129-526 - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q62824 refseq:XP_220308 intact:EBI-6959516|intact:MINT-87397 intact:EBI-15812625|dip:DIP-48425N psi-mi:exoc4_rat(display_long)|uniprotkb:Exoc4(gene name)|psi-mi:Exoc4(display_short)|uniprotkb:Sec8(gene name synonym)|uniprotkb:Sec8l1(gene name synonym)|uniprotkb:Exocyst complex component Sec8(gene name synonym) psi-mi:rkibra(display_long) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Rosse et al. (2009) pubmed:19885391|doi:10.1371/journal.pbio.1000235|imex:IM-14171 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15812628|imex:IM-14171-7|dip:DIP-102884E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043209"(myelin sheath)|go:"GO:0044091"(membrane biogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055108"(Golgi to transport vesicle transport)|go:"GO:0090522"(vesicle tethering involved in exocytosis)|go:"GO:0090543"(Flemming body)|interpro:IPR007191(Sec8 exocyst complex component specific domain)|interpro:IPR039682|go:"GO:0032584"(growth cone membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0000145"(exocyst)|go:"GO:0005902"(microvillus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006904"(vesicle docking involved in exocytosis)|reactome:R-RNO-264876|refseq:NP_446327.1|rgd:621791|dip:DIP-40985N|reactome:R-RNO-5620916 - psi-mi:"MI:0465"(dip) function:Component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane|comment:mint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2017/08/06 2017/08/10 rogid:+UaPRKfrnwMX9fQS6BS63c8dh2E10116 - - false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q62824 uniprotkb:F1M7Y5 intact:EBI-6959516|intact:MINT-87397 intact:EBI-8795211|ensembl:ENSRNOP00000012924|uniprotkb:B1PZT8 psi-mi:exoc4_rat(display_long)|uniprotkb:Exoc4(gene name)|psi-mi:Exoc4(display_short)|uniprotkb:Sec8(gene name synonym)|uniprotkb:Sec8l1(gene name synonym)|uniprotkb:Exocyst complex component Sec8(gene name synonym) psi-mi:kpci_rat(display_long)|uniprotkb:Prkci(gene name)|psi-mi:Prkci(display_short)|uniprotkb:Pkcl(gene name synonym)|uniprotkb:Atypical protein kinase C-lambda/iota(gene name synonym)|uniprotkb:nPKC-iota(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Rosse et al. (2009) pubmed:19885391|doi:10.1371/journal.pbio.1000235|imex:IM-14171 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15812628|imex:IM-14171-7|dip:DIP-102884E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043209"(myelin sheath)|go:"GO:0044091"(membrane biogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055108"(Golgi to transport vesicle transport)|go:"GO:0090522"(vesicle tethering involved in exocytosis)|go:"GO:0090543"(Flemming body)|interpro:IPR007191(Sec8 exocyst complex component specific domain)|interpro:IPR039682|go:"GO:0032584"(growth cone membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0000145"(exocyst)|go:"GO:0005902"(microvillus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006904"(vesicle docking involved in exocytosis)|reactome:R-RNO-264876|refseq:NP_446327.1|rgd:621791|dip:DIP-40985N|reactome:R-RNO-5620916 go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031252"(cell leading edge)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045177"(apical part of cell)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046872"(metal ion binding)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034661|interpro:IPR034877|mint:F1M7Y5|reactome:R-RNO-1912408|reactome:R-RNO-209543|reactome:R-RNO-420029|ensembl:ENSRNOG00000009652(gene)|ensembl:ENSRNOT00000012924(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|rgd:620961|refseq:NP_114448.1 psi-mi:"MI:0465"(dip) function:Component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane|comment:mint crc64:60035F56E7547C57 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2017/08/06 2017/08/10 rogid:+UaPRKfrnwMX9fQS6BS63c8dh2E10116 rogid:9fMfrsfmnMxuDPL2eYWYgGgSrU810116 - false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96KP1 uniprotkb:Q9NV70 intact:EBI-465715|uniprotkb:Q5JPC8|uniprotkb:Q96AN6|uniprotkb:Q9NUZ8|uniprotkb:Q9UJM7|ensembl:ENSP00000230449|uniprotkb:B2RBE6 intact:EBI-1045313|uniprotkb:Q504V4|uniprotkb:Q8WUE7|uniprotkb:Q96T15|uniprotkb:Q9NZE4|ensembl:ENSP00000326514|ensembl:ENSP00000370695 psi-mi:exoc2_human(display_long)|uniprotkb:EXOC2(gene name)|psi-mi:EXOC2(display_short)|uniprotkb:SEC5(gene name synonym)|uniprotkb:SEC5L1(gene name synonym)|uniprotkb:Exocyst complex component Sec5(gene name synonym) psi-mi:exoc1_human(display_long)|uniprotkb:Exocyst complex component Sec3(gene name synonym)|uniprotkb:EXOC1(gene name)|psi-mi:EXOC1(display_short)|uniprotkb:SEC3(gene name synonym)|uniprotkb:SEC3L1(gene name synonym)|uniprotkb:BM-012(orf name) psi-mi:"MI:0018"(two hybrid) Rosse et al. (2009) pubmed:19885391|doi:10.1371/journal.pbio.1000235|imex:IM-14171 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15812646|imex:IM-14171-8|dip:DIP-102886E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000112685(gene)|ensembl:ENST00000230449(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0090543"(Flemming body)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR029175|interpro:IPR039481|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|refseq:XP_016866507.1|refseq:XP_016866508.1|refseq:XP_016866509.1|refseq:XP_016866510.1|refseq:XP_016866511.1|refseq:XP_016866512.1|refseq:XP_016866513.1|refseq:NP_060773.3|dip:DIP-31795N refseq:NP_001020095.1|refseq:NP_060731.2|refseq:NP_839955.1|ensembl:ENSG00000090989(gene)|ensembl:ENST00000346134(transcript)|ensembl:ENST00000381295(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051607"(defense response to virus)|go:"GO:0090543"(Flemming body)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|interpro:IPR019160|interpro:IPR028258|mint:Q9NV70|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|refseq:XP_016863898.1|dip:DIP-37579N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:7p+4vZ18z6u2PJY0GzbHY+ro0v89606 rogid:DKEfnn4CJkBSIdGRfVy+znSPOrc9606 rigid:96i+Rjay3+99wSe0jqMt0udaNws false sufficient binding region:96-252 - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q62824 uniprotkb:Q8IX03-1 intact:EBI-6959516|intact:MINT-87397 intact:EBI-15812469|ensembl:ENSP00000265293 psi-mi:exoc4_rat(display_long)|uniprotkb:Exoc4(gene name)|psi-mi:Exoc4(display_short)|uniprotkb:Sec8(gene name synonym)|uniprotkb:Sec8l1(gene name synonym)|uniprotkb:Exocyst complex component Sec8(gene name synonym) psi-mi:q8ix03-1(display_long)|uniprotkb:WWC1(gene name)|psi-mi:WWC1(display_short)|uniprotkb:KIAA0869(gene name synonym)|uniprotkb:HBeAg-binding protein 3(gene name synonym)|uniprotkb:Kidney and brain protein(gene name synonym)|uniprotkb:WW domain-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rosse et al. (2009) pubmed:19885391|doi:10.1371/journal.pbio.1000235|imex:IM-14171 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15812606|imex:IM-14171-6|dip:DIP-102883E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043209"(myelin sheath)|go:"GO:0044091"(membrane biogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055108"(Golgi to transport vesicle transport)|go:"GO:0090522"(vesicle tethering involved in exocytosis)|go:"GO:0090543"(Flemming body)|interpro:IPR007191(Sec8 exocyst complex component specific domain)|interpro:IPR039682|go:"GO:0032584"(growth cone membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0000145"(exocyst)|go:"GO:0005902"(microvillus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006904"(vesicle docking involved in exocytosis)|reactome:R-RNO-264876|refseq:NP_446327.1|rgd:621791|dip:DIP-40985N|reactome:R-RNO-5620916 ensembl:ENSG00000113645(gene)|ensembl:ENST00000265293(transcript)|intact:EBI-715828(isoform-parent) psi-mi:"MI:0465"(dip) function:Component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane|comment:mint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2017/08/06 2017/08/10 rogid:+UaPRKfrnwMX9fQS6BS63c8dh2E10116 rogid:AGllK9/JguvRQEPw79FYfSgPjiU9606 rigid:4jGpQjiKKYhZTCH+lN0Sw3A7dEA false - myc tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96A65 uniprotkb:Q9NV70 intact:EBI-355383|intact:EBI-1058596|uniprotkb:Q9C0G4|uniprotkb:Q9H9K0|uniprotkb:Q9P102|uniprotkb:Q541U8|uniprotkb:E9PED2|ensembl:ENSP00000253861 intact:EBI-1045313|uniprotkb:Q504V4|uniprotkb:Q8WUE7|uniprotkb:Q96T15|uniprotkb:Q9NZE4|ensembl:ENSP00000326514|ensembl:ENSP00000370695 psi-mi:exoc4_human(display_long)|uniprotkb:EXOC4(gene name)|psi-mi:EXOC4(display_short)|uniprotkb:KIAA1699(gene name synonym)|uniprotkb:SEC8(gene name synonym)|uniprotkb:SEC8L1(gene name synonym)|uniprotkb:Exocyst complex component Sec8(gene name synonym) psi-mi:exoc1_human(display_long)|uniprotkb:Exocyst complex component Sec3(gene name synonym)|uniprotkb:EXOC1(gene name)|psi-mi:EXOC1(display_short)|uniprotkb:SEC3(gene name synonym)|uniprotkb:SEC3L1(gene name synonym)|uniprotkb:BM-012(orf name) psi-mi:"MI:0018"(two hybrid) Rosse et al. (2009) pubmed:19885391|doi:10.1371/journal.pbio.1000235|imex:IM-14171 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15812665|imex:IM-14171-9|dip:DIP-102887E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_068579.3|dip:DIP-32976N|ensembl:ENSG00000131558(gene)|ensembl:ENST00000253861(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032584"(growth cone membrane)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0090543"(Flemming body)|interpro:IPR007191(Sec8 exocyst complex component specific domain)|interpro:IPR039682|mint:Q96A65|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|go:"GO:0090522"(vesicle tethering involved in exocytosis) refseq:NP_001020095.1|refseq:NP_060731.2|refseq:NP_839955.1|ensembl:ENSG00000090989(gene)|ensembl:ENST00000346134(transcript)|ensembl:ENST00000381295(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051607"(defense response to virus)|go:"GO:0090543"(Flemming body)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|interpro:IPR019160|interpro:IPR028258|mint:Q9NV70|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|refseq:XP_016863898.1|dip:DIP-37579N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:cISO7v2OxFaDg0qe9XNV0Qoyby89606 rogid:DKEfnn4CJkBSIdGRfVy+znSPOrc9606 rigid:2oYi7ZJnVjXNM/a7CXJwdJ+tSsU false sufficient binding region:28-167 - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q62824 uniprotkb:Q8IX03-1 intact:EBI-6959516|intact:MINT-87397 intact:EBI-15812469|ensembl:ENSP00000265293 psi-mi:exoc4_rat(display_long)|uniprotkb:Exoc4(gene name)|psi-mi:Exoc4(display_short)|uniprotkb:Sec8(gene name synonym)|uniprotkb:Sec8l1(gene name synonym)|uniprotkb:Exocyst complex component Sec8(gene name synonym) psi-mi:q8ix03-1(display_long)|uniprotkb:WWC1(gene name)|psi-mi:WWC1(display_short)|uniprotkb:KIAA0869(gene name synonym)|uniprotkb:HBeAg-binding protein 3(gene name synonym)|uniprotkb:Kidney and brain protein(gene name synonym)|uniprotkb:WW domain-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rosse et al. (2009) pubmed:19885391|doi:10.1371/journal.pbio.1000235|imex:IM-14171 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15812570|imex:IM-14171-4|dip:DIP-102883E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043209"(myelin sheath)|go:"GO:0044091"(membrane biogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055108"(Golgi to transport vesicle transport)|go:"GO:0090522"(vesicle tethering involved in exocytosis)|go:"GO:0090543"(Flemming body)|interpro:IPR007191(Sec8 exocyst complex component specific domain)|interpro:IPR039682|go:"GO:0032584"(growth cone membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0000145"(exocyst)|go:"GO:0005902"(microvillus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006904"(vesicle docking involved in exocytosis)|reactome:R-RNO-264876|refseq:NP_446327.1|rgd:621791|dip:DIP-40985N|reactome:R-RNO-5620916 ensembl:ENSG00000113645(gene)|ensembl:ENST00000265293(transcript)|intact:EBI-715828(isoform-parent) psi-mi:"MI:0465"(dip) function:Component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane|comment:mint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2017/08/06 2017/08/10 rogid:+UaPRKfrnwMX9fQS6BS63c8dh2E10116 rogid:AGllK9/JguvRQEPw79FYfSgPjiU9606 rigid:4jGpQjiKKYhZTCH+lN0Sw3A7dEA false - flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q62824 uniprotkb:F1M7Y5 intact:EBI-6959516|intact:MINT-87397 intact:EBI-8795211|ensembl:ENSRNOP00000012924|uniprotkb:B1PZT8 psi-mi:exoc4_rat(display_long)|uniprotkb:Exoc4(gene name)|psi-mi:Exoc4(display_short)|uniprotkb:Sec8(gene name synonym)|uniprotkb:Sec8l1(gene name synonym)|uniprotkb:Exocyst complex component Sec8(gene name synonym) psi-mi:kpci_rat(display_long)|uniprotkb:Prkci(gene name)|psi-mi:Prkci(display_short)|uniprotkb:Pkcl(gene name synonym)|uniprotkb:Atypical protein kinase C-lambda/iota(gene name synonym)|uniprotkb:nPKC-iota(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Rosse et al. (2009) pubmed:19885391|doi:10.1371/journal.pbio.1000235|imex:IM-14171 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15812589|imex:IM-14171-5|dip:DIP-102881E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043209"(myelin sheath)|go:"GO:0044091"(membrane biogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055108"(Golgi to transport vesicle transport)|go:"GO:0090522"(vesicle tethering involved in exocytosis)|go:"GO:0090543"(Flemming body)|interpro:IPR007191(Sec8 exocyst complex component specific domain)|interpro:IPR039682|go:"GO:0032584"(growth cone membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0000145"(exocyst)|go:"GO:0005902"(microvillus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006904"(vesicle docking involved in exocytosis)|reactome:R-RNO-264876|refseq:NP_446327.1|rgd:621791|dip:DIP-40985N|reactome:R-RNO-5620916 go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031252"(cell leading edge)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045177"(apical part of cell)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046872"(metal ion binding)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034661|interpro:IPR034877|mint:F1M7Y5|reactome:R-RNO-1912408|reactome:R-RNO-209543|reactome:R-RNO-420029|ensembl:ENSRNOG00000009652(gene)|ensembl:ENSRNOT00000012924(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|rgd:620961|refseq:NP_114448.1 psi-mi:"MI:0465"(dip) function:Component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane|comment:mint crc64:60035F56E7547C57 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2017/08/06 2017/08/10 rogid:+UaPRKfrnwMX9fQS6BS63c8dh2E10116 rogid:9fMfrsfmnMxuDPL2eYWYgGgSrU810116 rigid:EGL4QpzZve7iQX0VkxS+LMhgpcA false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q62824 uniprotkb:P09217 intact:EBI-6959516|intact:MINT-87397 intact:EBI-1551121|ensembl:ENSRNOP00000021285 psi-mi:exoc4_rat(display_long)|uniprotkb:Exoc4(gene name)|psi-mi:Exoc4(display_short)|uniprotkb:Sec8(gene name synonym)|uniprotkb:Sec8l1(gene name synonym)|uniprotkb:Exocyst complex component Sec8(gene name synonym) psi-mi:kpcz_rat(display_long)|uniprotkb:Prkcz(gene name)|psi-mi:Prkcz(display_short)|uniprotkb:Pkcz(gene name synonym)|uniprotkb:nPKC-zeta(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Rosse et al. (2009) pubmed:19885391|doi:10.1371/journal.pbio.1000235|imex:IM-14171 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15812684|imex:IM-14171-10|dip:DIP-102882E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043209"(myelin sheath)|go:"GO:0044091"(membrane biogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055108"(Golgi to transport vesicle transport)|go:"GO:0090522"(vesicle tethering involved in exocytosis)|go:"GO:0090543"(Flemming body)|interpro:IPR007191(Sec8 exocyst complex component specific domain)|interpro:IPR039682|go:"GO:0032584"(growth cone membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0000145"(exocyst)|go:"GO:0005902"(microvillus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006904"(vesicle docking involved in exocytosis)|reactome:R-RNO-264876|refseq:NP_446327.1|rgd:621791|dip:DIP-40985N|reactome:R-RNO-5620916 refseq:XP_006239598.1|rgd:3399|refseq:NP_071952.1|dip:DIP-40867N|ensembl:ENSRNOG00000015480(gene)|ensembl:ENSRNOT00000021285(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001725"(stress fiber)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007616"(long-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045179"(apical cortex)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990138"(neuron projection extension)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034877|rcsb pdb:4MJS|reactome:R-RNO-2173791|reactome:R-RNO-5218921|reactome:R-RNO-5668599|reactome:R-RNO-9634635 psi-mi:"MI:0465"(dip) function:Component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane|comment:mint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2017/08/06 2017/08/10 rogid:+UaPRKfrnwMX9fQS6BS63c8dh2E10116 rogid:2qGiTRy5459eks3RiwpXPxWmZRk10116 rigid:1IBmROs4bY5tlYsVM/4406guA3k false - myc tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)