#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P10321	uniprotkb:P43632	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	intact:EBI-13916812|ensembl:ENSP00000477744|ensembl:ENSP00000478241|ensembl:ENSP00000479843|ensembl:ENSP00000480062|ensembl:ENSP00000481319|ensembl:ENSP00000481753|ensembl:ENSP00000483112|ensembl:ENSP00000483274|ensembl:ENSP00000484123|ensembl:ENSP00000491676|ensembl:ENSP00000492248|ensembl:ENSP00000492546|ensembl:ENSP00000494622|ensembl:ENSP00000494670|ensembl:ENSP00000495680|uniprotkb:Q6H2G7	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:ki2s4_human(display_long)|uniprotkb:KIR2DS4(gene name)|psi-mi:KIR2DS4(display_short)|uniprotkb:CD158I(gene name synonym)|uniprotkb:KKA3(gene name synonym)|uniprotkb:NKAT8(gene name synonym)|uniprotkb:CD158 antigen-like family member I(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 8(gene name synonym)|uniprotkb:P58 natural killer cell receptor clones CL-39/CL-17(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13916809|imex:IM-25681-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	ensembl:ENSG00000274406(gene)|ensembl:ENSG00000274947(gene)|ensembl:ENSG00000274957(gene)|ensembl:ENSG00000275353(gene)|ensembl:ENSG00000275731(gene)|ensembl:ENSG00000283870(gene)|ensembl:ENSG00000276154(gene)|ensembl:ENSG00000283882(gene)|ensembl:ENSG00000284264(gene)|ensembl:ENSG00000276395(gene)|ensembl:ENST00000611311(transcript)|ensembl:ENST00000612783(transcript)|ensembl:ENST00000613654(transcript)|ensembl:ENST00000614639(transcript)|ensembl:ENST00000617469(transcript)|ensembl:ENST00000617825(transcript)|ensembl:ENST00000619771(transcript)|ensembl:ENST00000620669(transcript)|ensembl:ENST00000621436(transcript)|ensembl:ENST00000638566(transcript)|ensembl:ENST00000640817(transcript)|ensembl:ENSG00000276634(gene)|ensembl:ENST00000640941(transcript)|ensembl:ENSG00000276885(gene)|ensembl:ENST00000642862(transcript)|ensembl:ENST00000644051(transcript)|ensembl:ENST00000644154(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0023029"(MHC class Ib protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3H8N|reactome:R-HSA-2172127|refseq:NP_001268900.1|refseq:NP_001268901.1|refseq:NP_036446.3	-	-	-	figure legend:Fig 1,5|comment:C1601 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	rogid:3VgxxvBA5EkKvrqpyjzOu88pG649606	rigid:KQr//PmhIgYcGeNbxrS9lUjifo4	false	-	necessary binding region:152-304|mutation disrupting interaction strength:65-65|fc-igg tag:?-?|mutation decreasing interaction strength:123-123|mutation with no effect:205-205|mutation with no effect:92-93	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:A0A583ZBW7	uniprotkb:P43632	intact:EBI-13916865|uniprotkb:O02865|uniprotkb:O19676|uniprotkb:P30500|uniprotkb:Q29986|uniprotkb:Q9UQS9	intact:EBI-13916812|ensembl:ENSP00000477744|ensembl:ENSP00000478241|ensembl:ENSP00000479843|ensembl:ENSP00000480062|ensembl:ENSP00000481319|ensembl:ENSP00000481753|ensembl:ENSP00000483112|ensembl:ENSP00000483274|ensembl:ENSP00000484123|ensembl:ENSP00000491676|ensembl:ENSP00000492248|ensembl:ENSP00000492546|ensembl:ENSP00000494622|ensembl:ENSP00000494670|ensembl:ENSP00000495680|uniprotkb:Q6H2G7	psi-mi:1c01_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)|uniprotkb:HLAC(gene name synonym)|uniprotkb:MHC class I antigen Cw*1(gene name synonym)	psi-mi:ki2s4_human(display_long)|uniprotkb:KIR2DS4(gene name)|psi-mi:KIR2DS4(display_short)|uniprotkb:CD158I(gene name synonym)|uniprotkb:KKA3(gene name synonym)|uniprotkb:NKAT8(gene name synonym)|uniprotkb:CD158 antigen-like family member I(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 8(gene name synonym)|uniprotkb:P58 natural killer cell receptor clones CL-39/CL-17(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13916861|imex:IM-25681-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0055038"(recycling endosome membrane)|uniprotkb:P10321(see-also)|ensembl:ENST00000438171|ensembl:ENSP00000393374|ensembl:ENSG00000237022|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0009986"(cell surface)|go:"GO:0031901"(early endosome membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0000139"(Golgi membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0046977"(TAP binding)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060337"(type I interferon signaling pathway)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR036179|interpro:IPR037055	ensembl:ENSG00000274406(gene)|ensembl:ENSG00000274947(gene)|ensembl:ENSG00000274957(gene)|ensembl:ENSG00000275353(gene)|ensembl:ENSG00000275731(gene)|ensembl:ENSG00000283870(gene)|ensembl:ENSG00000276154(gene)|ensembl:ENSG00000283882(gene)|ensembl:ENSG00000284264(gene)|ensembl:ENSG00000276395(gene)|ensembl:ENST00000611311(transcript)|ensembl:ENST00000612783(transcript)|ensembl:ENST00000613654(transcript)|ensembl:ENST00000614639(transcript)|ensembl:ENST00000617469(transcript)|ensembl:ENST00000617825(transcript)|ensembl:ENST00000619771(transcript)|ensembl:ENST00000620669(transcript)|ensembl:ENST00000621436(transcript)|ensembl:ENST00000638566(transcript)|ensembl:ENST00000640817(transcript)|ensembl:ENSG00000276634(gene)|ensembl:ENST00000640941(transcript)|ensembl:ENSG00000276885(gene)|ensembl:ENST00000642862(transcript)|ensembl:ENST00000644051(transcript)|ensembl:ENST00000644154(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0023029"(MHC class Ib protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3H8N|reactome:R-HSA-2172127|refseq:NP_001268900.1|refseq:NP_001268901.1|refseq:NP_036446.3	-	no-uniprot-update:|caution:"The protein could not be merged with EBI-1051396 because of some conflicts with the protein sequence (features which cannot be shifted)."	-	figure legend:Fig 1-2,5|comment:C0102 allele;weak binding|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2017/02/20	rogid:yZNtsKoOb6HhKK3W3XprXxlPin09606	rogid:3VgxxvBA5EkKvrqpyjzOu88pG649606	rigid:96kRFZ6V7avlSnsbNr+l6GTehD0	false	variant:92-92|variant:5-5|variant:179-179|variant:202-202|variant:364-364	necessary binding region:152-304|mutation with no effect:65-65|fc-igg tag:?-?|mutation with no effect:205-205|mutation decreasing interaction strength:123-123|mutation with no effect:92-93	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P10321	uniprotkb:P43632	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	intact:EBI-13916812|ensembl:ENSP00000477744|ensembl:ENSP00000478241|ensembl:ENSP00000479843|ensembl:ENSP00000480062|ensembl:ENSP00000481319|ensembl:ENSP00000481753|ensembl:ENSP00000483112|ensembl:ENSP00000483274|ensembl:ENSP00000484123|ensembl:ENSP00000491676|ensembl:ENSP00000492248|ensembl:ENSP00000492546|ensembl:ENSP00000494622|ensembl:ENSP00000494670|ensembl:ENSP00000495680|uniprotkb:Q6H2G7	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:ki2s4_human(display_long)|uniprotkb:KIR2DS4(gene name)|psi-mi:KIR2DS4(display_short)|uniprotkb:CD158I(gene name synonym)|uniprotkb:KKA3(gene name synonym)|uniprotkb:NKAT8(gene name synonym)|uniprotkb:CD158 antigen-like family member I(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 8(gene name synonym)|uniprotkb:P58 natural killer cell receptor clones CL-39/CL-17(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13916929|imex:IM-25681-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	ensembl:ENSG00000274406(gene)|ensembl:ENSG00000274947(gene)|ensembl:ENSG00000274957(gene)|ensembl:ENSG00000275353(gene)|ensembl:ENSG00000275731(gene)|ensembl:ENSG00000283870(gene)|ensembl:ENSG00000276154(gene)|ensembl:ENSG00000283882(gene)|ensembl:ENSG00000284264(gene)|ensembl:ENSG00000276395(gene)|ensembl:ENST00000611311(transcript)|ensembl:ENST00000612783(transcript)|ensembl:ENST00000613654(transcript)|ensembl:ENST00000614639(transcript)|ensembl:ENST00000617469(transcript)|ensembl:ENST00000617825(transcript)|ensembl:ENST00000619771(transcript)|ensembl:ENST00000620669(transcript)|ensembl:ENST00000621436(transcript)|ensembl:ENST00000638566(transcript)|ensembl:ENST00000640817(transcript)|ensembl:ENSG00000276634(gene)|ensembl:ENST00000640941(transcript)|ensembl:ENSG00000276885(gene)|ensembl:ENST00000642862(transcript)|ensembl:ENST00000644051(transcript)|ensembl:ENST00000644154(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0023029"(MHC class Ib protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3H8N|reactome:R-HSA-2172127|refseq:NP_001268900.1|refseq:NP_001268901.1|refseq:NP_036446.3	-	-	-	figure legend:Fig 1-3,5|comment:C1402 allele;weak binding|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	rogid:3VgxxvBA5EkKvrqpyjzOu88pG649606	rigid:KQr//PmhIgYcGeNbxrS9lUjifo4	false	-	necessary binding region:152-304|mutation decreasing interaction strength:65-65|fc-igg tag:?-?|mutation decreasing interaction strength:92-93|mutation decreasing interaction strength:123-123|mutation decreasing interaction strength:205-205	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P10321	uniprotkb:P43632	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	intact:EBI-13916812|ensembl:ENSP00000477744|ensembl:ENSP00000478241|ensembl:ENSP00000479843|ensembl:ENSP00000480062|ensembl:ENSP00000481319|ensembl:ENSP00000481753|ensembl:ENSP00000483112|ensembl:ENSP00000483274|ensembl:ENSP00000484123|ensembl:ENSP00000491676|ensembl:ENSP00000492248|ensembl:ENSP00000492546|ensembl:ENSP00000494622|ensembl:ENSP00000494670|ensembl:ENSP00000495680|uniprotkb:Q6H2G7	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:ki2s4_human(display_long)|uniprotkb:KIR2DS4(gene name)|psi-mi:KIR2DS4(display_short)|uniprotkb:CD158I(gene name synonym)|uniprotkb:KKA3(gene name synonym)|uniprotkb:NKAT8(gene name synonym)|uniprotkb:CD158 antigen-like family member I(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 8(gene name synonym)|uniprotkb:P58 natural killer cell receptor clones CL-39/CL-17(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13916944|imex:IM-25681-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	ensembl:ENSG00000274406(gene)|ensembl:ENSG00000274947(gene)|ensembl:ENSG00000274957(gene)|ensembl:ENSG00000275353(gene)|ensembl:ENSG00000275731(gene)|ensembl:ENSG00000283870(gene)|ensembl:ENSG00000276154(gene)|ensembl:ENSG00000283882(gene)|ensembl:ENSG00000284264(gene)|ensembl:ENSG00000276395(gene)|ensembl:ENST00000611311(transcript)|ensembl:ENST00000612783(transcript)|ensembl:ENST00000613654(transcript)|ensembl:ENST00000614639(transcript)|ensembl:ENST00000617469(transcript)|ensembl:ENST00000617825(transcript)|ensembl:ENST00000619771(transcript)|ensembl:ENST00000620669(transcript)|ensembl:ENST00000621436(transcript)|ensembl:ENST00000638566(transcript)|ensembl:ENST00000640817(transcript)|ensembl:ENSG00000276634(gene)|ensembl:ENST00000640941(transcript)|ensembl:ENSG00000276885(gene)|ensembl:ENST00000642862(transcript)|ensembl:ENST00000644051(transcript)|ensembl:ENST00000644154(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0023029"(MHC class Ib protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3H8N|reactome:R-HSA-2172127|refseq:NP_001268900.1|refseq:NP_001268901.1|refseq:NP_036446.3	-	-	-	figure legend:Fig 1-4,5|comment:C0501 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	rogid:3VgxxvBA5EkKvrqpyjzOu88pG649606	rigid:KQr//PmhIgYcGeNbxrS9lUjifo4	false	-	necessary binding region:152-304|mutation with no effect:65-65|fc-igg tag:?-?|mutation decreasing interaction strength:205-205|mutation decreasing interaction strength:92-93|mutation decreasing interaction strength:123-123	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:A0A583ZBW8	uniprotkb:P43632	intact:EBI-9978392|uniprotkb:P30502	intact:EBI-13916812|ensembl:ENSP00000477744|ensembl:ENSP00000478241|ensembl:ENSP00000479843|ensembl:ENSP00000480062|ensembl:ENSP00000481319|ensembl:ENSP00000481753|ensembl:ENSP00000483112|ensembl:ENSP00000483274|ensembl:ENSP00000484123|ensembl:ENSP00000491676|ensembl:ENSP00000492248|ensembl:ENSP00000492546|ensembl:ENSP00000494622|ensembl:ENSP00000494670|ensembl:ENSP00000495680|uniprotkb:Q6H2G7	psi-mi:1c02_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)|uniprotkb:HLAC(gene name synonym)|uniprotkb:MHC class I antigen Cw*2(gene name synonym)	psi-mi:ki2s4_human(display_long)|uniprotkb:KIR2DS4(gene name)|psi-mi:KIR2DS4(display_short)|uniprotkb:CD158I(gene name synonym)|uniprotkb:KKA3(gene name synonym)|uniprotkb:NKAT8(gene name synonym)|uniprotkb:CD158 antigen-like family member I(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 8(gene name synonym)|uniprotkb:P58 natural killer cell receptor clones CL-39/CL-17(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13917002|imex:IM-25681-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0055038"(recycling endosome membrane)|uniprotkb:P10321(see-also)|go:"GO:0009986"(cell surface)|go:"GO:0031901"(early endosome membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0000139"(Golgi membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0046977"(TAP binding)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060337"(type I interferon signaling pathway)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|ensembl:ENST00000420206|ensembl:ENSP00000410214|ensembl:ENSG00000228299|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|interpro:IPR036179|interpro:IPR037055|uniprotkb:A0A0B7NNJ6(see-also)	ensembl:ENSG00000274406(gene)|ensembl:ENSG00000274947(gene)|ensembl:ENSG00000274957(gene)|ensembl:ENSG00000275353(gene)|ensembl:ENSG00000275731(gene)|ensembl:ENSG00000283870(gene)|ensembl:ENSG00000276154(gene)|ensembl:ENSG00000283882(gene)|ensembl:ENSG00000284264(gene)|ensembl:ENSG00000276395(gene)|ensembl:ENST00000611311(transcript)|ensembl:ENST00000612783(transcript)|ensembl:ENST00000613654(transcript)|ensembl:ENST00000614639(transcript)|ensembl:ENST00000617469(transcript)|ensembl:ENST00000617825(transcript)|ensembl:ENST00000619771(transcript)|ensembl:ENST00000620669(transcript)|ensembl:ENST00000621436(transcript)|ensembl:ENST00000638566(transcript)|ensembl:ENST00000640817(transcript)|ensembl:ENSG00000276634(gene)|ensembl:ENST00000640941(transcript)|ensembl:ENSG00000276885(gene)|ensembl:ENST00000642862(transcript)|ensembl:ENST00000644051(transcript)|ensembl:ENST00000644154(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0023029"(MHC class Ib protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3H8N|reactome:R-HSA-2172127|refseq:NP_001268900.1|refseq:NP_001268901.1|refseq:NP_036446.3	-	no-uniprot-update:|caution:"The protein could not be merged with EBI-1051396 because of some conflicts with the protein sequence (features which cannot be shifted)."	-	figure legend:Fig 1-5,5|comment:C0202 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2017/02/20	rogid:to6Sq6pB+Vn5nSM0v5vkRoYCpqk9606	rogid:3VgxxvBA5EkKvrqpyjzOu88pG649606	rigid:EWI2OJ95MQDJ5AZ0cEbOq0Ju8as	false	variant:179-179|variant:202-202|variant:364-364|variant:10-10|variant:73-74|variant:5-5|variant:92-92	necessary binding region:152-304|mutation decreasing interaction strength:123-123|mutation increasing interaction strength:65-65|mutation decreasing interaction strength:92-93|mutation decreasing interaction strength:205-205|fc-igg tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P10321	uniprotkb:P43632	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	intact:EBI-13916812|ensembl:ENSP00000477744|ensembl:ENSP00000478241|ensembl:ENSP00000479843|ensembl:ENSP00000480062|ensembl:ENSP00000481319|ensembl:ENSP00000481753|ensembl:ENSP00000483112|ensembl:ENSP00000483274|ensembl:ENSP00000484123|ensembl:ENSP00000491676|ensembl:ENSP00000492248|ensembl:ENSP00000492546|ensembl:ENSP00000494622|ensembl:ENSP00000494670|ensembl:ENSP00000495680|uniprotkb:Q6H2G7	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:ki2s4_human(display_long)|uniprotkb:KIR2DS4(gene name)|psi-mi:KIR2DS4(display_short)|uniprotkb:CD158I(gene name synonym)|uniprotkb:KKA3(gene name synonym)|uniprotkb:NKAT8(gene name synonym)|uniprotkb:CD158 antigen-like family member I(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 8(gene name synonym)|uniprotkb:P58 natural killer cell receptor clones CL-39/CL-17(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13917025|imex:IM-25681-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	ensembl:ENSG00000274406(gene)|ensembl:ENSG00000274947(gene)|ensembl:ENSG00000274957(gene)|ensembl:ENSG00000275353(gene)|ensembl:ENSG00000275731(gene)|ensembl:ENSG00000283870(gene)|ensembl:ENSG00000276154(gene)|ensembl:ENSG00000283882(gene)|ensembl:ENSG00000284264(gene)|ensembl:ENSG00000276395(gene)|ensembl:ENST00000611311(transcript)|ensembl:ENST00000612783(transcript)|ensembl:ENST00000613654(transcript)|ensembl:ENST00000614639(transcript)|ensembl:ENST00000617469(transcript)|ensembl:ENST00000617825(transcript)|ensembl:ENST00000619771(transcript)|ensembl:ENST00000620669(transcript)|ensembl:ENST00000621436(transcript)|ensembl:ENST00000638566(transcript)|ensembl:ENST00000640817(transcript)|ensembl:ENSG00000276634(gene)|ensembl:ENST00000640941(transcript)|ensembl:ENSG00000276885(gene)|ensembl:ENST00000642862(transcript)|ensembl:ENST00000644051(transcript)|ensembl:ENST00000644154(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0023029"(MHC class Ib protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3H8N|reactome:R-HSA-2172127|refseq:NP_001268900.1|refseq:NP_001268901.1|refseq:NP_036446.3	-	-	-	figure legend:Fig 1-6,5|comment:"C04:01 allele;very low binding"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	rogid:3VgxxvBA5EkKvrqpyjzOu88pG649606	rigid:KQr//PmhIgYcGeNbxrS9lUjifo4	false	-	necessary binding region:152-304|mutation with no effect:65-65|mutation decreasing interaction strength:123-123|mutation decreasing interaction strength:205-205|fc-igg tag:?-?|mutation decreasing interaction strength:92-93	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q5S3G3	uniprotkb:P43632	intact:EBI-4290427|uniprotkb:Q9BCN0|uniprotkb:Q9MYI5|uniprotkb:Q9TQE9|uniprotkb:Q9TQP6|uniprotkb:Q9TQP7|uniprotkb:Q5S3G1	intact:EBI-13916812|ensembl:ENSP00000477744|ensembl:ENSP00000478241|ensembl:ENSP00000479843|ensembl:ENSP00000480062|ensembl:ENSP00000481319|ensembl:ENSP00000481753|ensembl:ENSP00000483112|ensembl:ENSP00000483274|ensembl:ENSP00000484123|ensembl:ENSP00000491676|ensembl:ENSP00000492248|ensembl:ENSP00000492546|ensembl:ENSP00000494622|ensembl:ENSP00000494670|ensembl:ENSP00000495680|uniprotkb:Q6H2G7	psi-mi:q5s3g3_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:HLAA(gene name synonym)|uniprotkb:MHC class I antigen A*11(gene name synonym)	psi-mi:ki2s4_human(display_long)|uniprotkb:KIR2DS4(gene name)|psi-mi:KIR2DS4(display_short)|uniprotkb:CD158I(gene name synonym)|uniprotkb:KKA3(gene name synonym)|uniprotkb:NKAT8(gene name synonym)|uniprotkb:CD158 antigen-like family member I(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 8(gene name synonym)|uniprotkb:P58 natural killer cell receptor clones CL-39/CL-17(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13917030|imex:IM-25681-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:P13746(see-also)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019882"(antigen processing and presentation)|interpro:IPR036179|interpro:IPR037055|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)	ensembl:ENSG00000274406(gene)|ensembl:ENSG00000274947(gene)|ensembl:ENSG00000274957(gene)|ensembl:ENSG00000275353(gene)|ensembl:ENSG00000275731(gene)|ensembl:ENSG00000283870(gene)|ensembl:ENSG00000276154(gene)|ensembl:ENSG00000283882(gene)|ensembl:ENSG00000284264(gene)|ensembl:ENSG00000276395(gene)|ensembl:ENST00000611311(transcript)|ensembl:ENST00000612783(transcript)|ensembl:ENST00000613654(transcript)|ensembl:ENST00000614639(transcript)|ensembl:ENST00000617469(transcript)|ensembl:ENST00000617825(transcript)|ensembl:ENST00000619771(transcript)|ensembl:ENST00000620669(transcript)|ensembl:ENST00000621436(transcript)|ensembl:ENST00000638566(transcript)|ensembl:ENST00000640817(transcript)|ensembl:ENSG00000276634(gene)|ensembl:ENST00000640941(transcript)|ensembl:ENSG00000276885(gene)|ensembl:ENST00000642862(transcript)|ensembl:ENST00000644051(transcript)|ensembl:ENST00000644154(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0023029"(MHC class Ib protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3H8N|reactome:R-HSA-2172127|refseq:NP_001268900.1|refseq:NP_001268901.1|refseq:NP_036446.3	-	-	-	figure legend:Fig 1-7,5|comment:"A1102  (E43K)  and A1101 alleles"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2017/02/20	rogid:zfvnDhAh7D90kAQGAuK6Ut2tWOA9606	rogid:3VgxxvBA5EkKvrqpyjzOu88pG649606	rigid:ZVFuAaMvV28v57LXTDimuJC8w6Y	false	mutation increasing interaction strength:43-43	necessary binding region:152-304|mutation disrupting interaction strength:65-65|fc-igg tag:?-?|mutation decreasing interaction strength:123-123|mutation disrupting interaction strength:92-93|mutation decreasing interaction strength:205-205	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q5S3G3	uniprotkb:F2VZG2	intact:EBI-4290427|uniprotkb:Q9BCN0|uniprotkb:Q9MYI5|uniprotkb:Q9TQE9|uniprotkb:Q9TQP6|uniprotkb:Q9TQP7|uniprotkb:Q5S3G1	intact:EBI-13917082	psi-mi:q5s3g3_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:HLAA(gene name synonym)|uniprotkb:MHC class I antigen A*11(gene name synonym)	psi-mi:f2vzg2_pantr(display_long)|uniprotkb:KIR2DS4(gene name)|psi-mi:KIR2DS4(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9598(pantr)|taxid:9598("Pan troglodytes (Chimpanzee)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13917073|imex:IM-25681-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:P13746(see-also)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019882"(antigen processing and presentation)|interpro:IPR036179|interpro:IPR037055|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)	go:"GO:0016021"(integral component of membrane)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR036179	-	-	-	figure legend:Fig 3-1|comment:"A1102  (E43K)  and A1101 alleles;both alleles bind."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2017/02/20	rogid:zfvnDhAh7D90kAQGAuK6Ut2tWOA9606	rogid:zUzu+eO2WhSsUW5WkKg5pvVmthk9598	rigid:DU5nrLxBtmfOT8OOFq2ep6fb6uA	false	mutation increasing interaction strength:43-43	fc-igg tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:A0A583ZBW7	uniprotkb:F2VZG2	intact:EBI-13916865|uniprotkb:O02865|uniprotkb:O19676|uniprotkb:P30500|uniprotkb:Q29986|uniprotkb:Q9UQS9	intact:EBI-13917082	psi-mi:1c01_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)|uniprotkb:HLAC(gene name synonym)|uniprotkb:MHC class I antigen Cw*1(gene name synonym)	psi-mi:f2vzg2_pantr(display_long)|uniprotkb:KIR2DS4(gene name)|psi-mi:KIR2DS4(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9598(pantr)|taxid:9598("Pan troglodytes (Chimpanzee)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13917160|imex:IM-25681-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0055038"(recycling endosome membrane)|uniprotkb:P10321(see-also)|ensembl:ENST00000438171|ensembl:ENSP00000393374|ensembl:ENSG00000237022|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0009986"(cell surface)|go:"GO:0031901"(early endosome membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0000139"(Golgi membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0046977"(TAP binding)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060337"(type I interferon signaling pathway)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR036179|interpro:IPR037055	go:"GO:0016021"(integral component of membrane)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR036179	-	no-uniprot-update:|caution:"The protein could not be merged with EBI-1051396 because of some conflicts with the protein sequence (features which cannot be shifted)."	-	figure legend:Fig 3-2|comment:C0102 allele;weak binding|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2017/02/20	rogid:yZNtsKoOb6HhKK3W3XprXxlPin09606	rogid:zUzu+eO2WhSsUW5WkKg5pvVmthk9598	rigid:IB4K7kuApl1zez2EhBQZPaUNqUs	false	variant:92-92|variant:5-5|variant:179-179|variant:202-202|variant:364-364	fc-igg tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q53YP1	uniprotkb:F2VZG2	intact:EBI-13917186|uniprotkb:O62883|uniprotkb:O78060|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:P30503|uniprotkb:Q29743|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q9GIK8|uniprotkb:Q9TQB4	intact:EBI-13917082	psi-mi:1c03_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)|uniprotkb:HLAC(gene name synonym)|uniprotkb:MHC class I antigen Cw*3(gene name synonym)	psi-mi:f2vzg2_pantr(display_long)|uniprotkb:KIR2DS4(gene name)|psi-mi:KIR2DS4(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9598(pantr)|taxid:9598("Pan troglodytes (Chimpanzee)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13917177|imex:IM-25681-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0055038"(recycling endosome membrane)|uniprotkb:P10321(see-also)|rcsb pdb:1EFX|ensembl:ENST00000457903|ensembl:ENSP00000390851|ensembl:ENSG00000225691|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0009986"(cell surface)|go:"GO:0031901"(early endosome membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0000139"(Golgi membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0046977"(TAP binding)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0045087"(innate immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060337"(type I interferon signaling pathway)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR036179|interpro:IPR037055	go:"GO:0016021"(integral component of membrane)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR036179	-	no-uniprot-update:|caution:"The protein could not be merged with EBI-1051396 because of some conflicts with the protein sequence (features which cannot be shifted)."	-	figure legend:Fig 3-3|comment:C0302 allele;weak binding|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2017/02/20	rogid:JFeUsl+FLKQrUF6Miog4kKzX3aE9606	rogid:zUzu+eO2WhSsUW5WkKg5pvVmthk9598	rigid:jDc046C5i72o4GIUnznsHBZplBc	false	variant:140-140|variant:119-119	fc-igg tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q546I7	uniprotkb:F2VZG2	intact:EBI-6163567|uniprotkb:P30506|uniprotkb:P30507	intact:EBI-13917082	psi-mi:1c08_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)|uniprotkb:HLAC(gene name synonym)|uniprotkb:MHC class I antigen Cw*8(gene name synonym)	psi-mi:f2vzg2_pantr(display_long)|uniprotkb:KIR2DS4(gene name)|psi-mi:KIR2DS4(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9598(pantr)|taxid:9598("Pan troglodytes (Chimpanzee)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13917246|imex:IM-25681-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4NT6|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR036179|interpro:IPR037055|ensembl:ENSG00000206435|ensembl:ENSG00000206452|ensembl:ENSP00000383195|ensembl:ENSP00000383244|uniprotkb:P10321(see-also)|go:"GO:0042612"(MHC class I protein complex)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0009986"(cell surface)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000400341|ensembl:ENST00000400394	go:"GO:0016021"(integral component of membrane)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR036179	-	no-uniprot-update:	-	figure legend:Fig 3-4|comment:C0801 allele;weak binding|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2017/02/20	rogid:87sh1Pl3u1Ci/a42gxKJbK1G8SI9606	rogid:zUzu+eO2WhSsUW5WkKg5pvVmthk9598	rigid:SvV6dERWqNIDoRyswJ7Q9yneAEw	false	-	fc-igg tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P10321	uniprotkb:F2VZG2	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	intact:EBI-13917082	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:f2vzg2_pantr(display_long)|uniprotkb:KIR2DS4(gene name)|psi-mi:KIR2DS4(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9598(pantr)|taxid:9598("Pan troglodytes (Chimpanzee)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13917255|imex:IM-25681-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	go:"GO:0016021"(integral component of membrane)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR036179	-	-	-	figure legend:Fig 3-5|comment:C1601 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	rogid:zUzu+eO2WhSsUW5WkKg5pvVmthk9598	rigid:AMtMzl5MxesbIdLoFuEJdsgzXJI	false	-	fc-igg tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P10321	uniprotkb:F2VZG2	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	intact:EBI-13917082	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:f2vzg2_pantr(display_long)|uniprotkb:KIR2DS4(gene name)|psi-mi:KIR2DS4(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9598(pantr)|taxid:9598("Pan troglodytes (Chimpanzee)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13917262|imex:IM-25681-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	go:"GO:0016021"(integral component of membrane)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR036179	-	-	-	figure legend:Fig 3-6|comment:C1502 allele;very weak binding|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	rogid:zUzu+eO2WhSsUW5WkKg5pvVmthk9598	rigid:AMtMzl5MxesbIdLoFuEJdsgzXJI	false	-	fc-igg tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P10321	uniprotkb:P43632	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	intact:EBI-13916812|ensembl:ENSP00000477744|ensembl:ENSP00000478241|ensembl:ENSP00000479843|ensembl:ENSP00000480062|ensembl:ENSP00000481319|ensembl:ENSP00000481753|ensembl:ENSP00000483112|ensembl:ENSP00000483274|ensembl:ENSP00000484123|ensembl:ENSP00000491676|ensembl:ENSP00000492248|ensembl:ENSP00000492546|ensembl:ENSP00000494622|ensembl:ENSP00000494670|ensembl:ENSP00000495680|uniprotkb:Q6H2G7	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:ki2s4_human(display_long)|uniprotkb:KIR2DS4(gene name)|psi-mi:KIR2DS4(display_short)|uniprotkb:CD158I(gene name synonym)|uniprotkb:KKA3(gene name synonym)|uniprotkb:NKAT8(gene name synonym)|uniprotkb:CD158 antigen-like family member I(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 8(gene name synonym)|uniprotkb:P58 natural killer cell receptor clones CL-39/CL-17(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13917288|imex:IM-25681-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	ensembl:ENSG00000274406(gene)|ensembl:ENSG00000274947(gene)|ensembl:ENSG00000274957(gene)|ensembl:ENSG00000275353(gene)|ensembl:ENSG00000275731(gene)|ensembl:ENSG00000283870(gene)|ensembl:ENSG00000276154(gene)|ensembl:ENSG00000283882(gene)|ensembl:ENSG00000284264(gene)|ensembl:ENSG00000276395(gene)|ensembl:ENST00000611311(transcript)|ensembl:ENST00000612783(transcript)|ensembl:ENST00000613654(transcript)|ensembl:ENST00000614639(transcript)|ensembl:ENST00000617469(transcript)|ensembl:ENST00000617825(transcript)|ensembl:ENST00000619771(transcript)|ensembl:ENST00000620669(transcript)|ensembl:ENST00000621436(transcript)|ensembl:ENST00000638566(transcript)|ensembl:ENST00000640817(transcript)|ensembl:ENSG00000276634(gene)|ensembl:ENST00000640941(transcript)|ensembl:ENSG00000276885(gene)|ensembl:ENST00000642862(transcript)|ensembl:ENST00000644051(transcript)|ensembl:ENST00000644154(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0023029"(MHC class Ib protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3H8N|reactome:R-HSA-2172127|refseq:NP_001268900.1|refseq:NP_001268901.1|refseq:NP_036446.3	-	-	-	figure legend:Fig 5|comment:C1701 allele; low binding|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	rogid:3VgxxvBA5EkKvrqpyjzOu88pG649606	rigid:KQr//PmhIgYcGeNbxrS9lUjifo4	false	-	mutation causing an interaction:65-65|mutation increasing interaction strength:92-93|mutation causing an interaction:205-205|fc-igg tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P10321	uniprotkb:P43632	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	intact:EBI-13916812|ensembl:ENSP00000477744|ensembl:ENSP00000478241|ensembl:ENSP00000479843|ensembl:ENSP00000480062|ensembl:ENSP00000481319|ensembl:ENSP00000481753|ensembl:ENSP00000483112|ensembl:ENSP00000483274|ensembl:ENSP00000484123|ensembl:ENSP00000491676|ensembl:ENSP00000492248|ensembl:ENSP00000492546|ensembl:ENSP00000494622|ensembl:ENSP00000494670|ensembl:ENSP00000495680|uniprotkb:Q6H2G7	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:ki2s4_human(display_long)|uniprotkb:KIR2DS4(gene name)|psi-mi:KIR2DS4(display_short)|uniprotkb:CD158I(gene name synonym)|uniprotkb:KKA3(gene name synonym)|uniprotkb:NKAT8(gene name synonym)|uniprotkb:CD158 antigen-like family member I(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 8(gene name synonym)|uniprotkb:P58 natural killer cell receptor clones CL-39/CL-17(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13917297|imex:IM-25681-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	ensembl:ENSG00000274406(gene)|ensembl:ENSG00000274947(gene)|ensembl:ENSG00000274957(gene)|ensembl:ENSG00000275353(gene)|ensembl:ENSG00000275731(gene)|ensembl:ENSG00000283870(gene)|ensembl:ENSG00000276154(gene)|ensembl:ENSG00000283882(gene)|ensembl:ENSG00000284264(gene)|ensembl:ENSG00000276395(gene)|ensembl:ENST00000611311(transcript)|ensembl:ENST00000612783(transcript)|ensembl:ENST00000613654(transcript)|ensembl:ENST00000614639(transcript)|ensembl:ENST00000617469(transcript)|ensembl:ENST00000617825(transcript)|ensembl:ENST00000619771(transcript)|ensembl:ENST00000620669(transcript)|ensembl:ENST00000621436(transcript)|ensembl:ENST00000638566(transcript)|ensembl:ENST00000640817(transcript)|ensembl:ENSG00000276634(gene)|ensembl:ENST00000640941(transcript)|ensembl:ENSG00000276885(gene)|ensembl:ENST00000642862(transcript)|ensembl:ENST00000644051(transcript)|ensembl:ENST00000644154(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0023029"(MHC class Ib protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3H8N|reactome:R-HSA-2172127|refseq:NP_001268900.1|refseq:NP_001268901.1|refseq:NP_036446.3	-	-	-	figure legend:Fig 5i|comment:C1802 allele; low binding|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	rogid:3VgxxvBA5EkKvrqpyjzOu88pG649606	rigid:KQr//PmhIgYcGeNbxrS9lUjifo4	false	variant:272-272	mutation causing an interaction:65-65|fc-igg tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P01889	uniprotkb:P43632	intact:EBI-1046513|ensembl:ENSP00000399168|uniprotkb:O62901|uniprotkb:O95730|uniprotkb:O98140|uniprotkb:P79542|uniprotkb:Q95369|uniprotkb:Q95J00|uniprotkb:Q9GJ20|uniprotkb:Q9MY78|uniprotkb:Q9MYF4|uniprotkb:Q9TQH6|uniprotkb:Q9TQM2|uniprotkb:Q9UQT0|intact:EBI-1049793|intact:EBI-6163549|intact:EBI-6163552|intact:EBI-6163582|intact:EBI-6163570|intact:EBI-6163579|intact:EBI-6163555|intact:EBI-9978548|intact:EBI-1047909|intact:EBI-8770324|uniprotkb:A0A2I6Q7B5|uniprotkb:B0V0B8|uniprotkb:G3GN01|uniprotkb:O02862|uniprotkb:O02956|uniprotkb:O02957|uniprotkb:O02960|uniprotkb:O19555|uniprotkb:O19556|uniprotkb:O19595|uniprotkb:O19615|uniprotkb:O19624|uniprotkb:O78163|uniprotkb:O78172|intact:EBI-1054175|uniprotkb:O19625|uniprotkb:O19627|uniprotkb:O19641|uniprotkb:O19651|uniprotkb:O19675|uniprotkb:O19692|uniprotkb:O19758|uniprotkb:O19779|uniprotkb:O19783|uniprotkb:O46702|uniprotkb:O62897|uniprotkb:O62915|uniprotkb:O62917|uniprotkb:O62919|uniprotkb:O77933|uniprotkb:O77959|uniprotkb:O78053|uniprotkb:O78138|uniprotkb:O78160|uniprotkb:O78173|uniprotkb:O78180|uniprotkb:O78217|uniprotkb:P01890|uniprotkb:P03989|uniprotkb:P10317|uniprotkb:P10318|uniprotkb:P10319|uniprotkb:P10320|uniprotkb:P18463|uniprotkb:P18464|uniprotkb:P18465|uniprotkb:P19373|uniprotkb:P30460|uniprotkb:P30461|uniprotkb:P30462|uniprotkb:P30463|uniprotkb:P30464|uniprotkb:P30465|uniprotkb:P30466|uniprotkb:P30467|uniprotkb:P30468|uniprotkb:P30469|uniprotkb:P30470|uniprotkb:P30471|uniprotkb:P30472|uniprotkb:P30473|uniprotkb:P30474|uniprotkb:P30475|uniprotkb:P30476|uniprotkb:P30477|uniprotkb:P30478|uniprotkb:P30479|uniprotkb:P30480|uniprotkb:P30481|uniprotkb:Q29693|uniprotkb:Q29695|uniprotkb:Q29697|uniprotkb:Q29718|uniprotkb:Q29742|uniprotkb:Q29749|uniprotkb:Q29762|uniprotkb:Q29764|uniprotkb:Q29829|uniprotkb:Q29836|uniprotkb:Q29842|uniprotkb:Q29845|uniprotkb:Q29846|uniprotkb:Q29847|uniprotkb:Q29848|uniprotkb:Q29850|uniprotkb:Q29851|uniprotkb:Q29852|uniprotkb:P30482|uniprotkb:P30483|uniprotkb:P30484|uniprotkb:P30485|uniprotkb:P30486|uniprotkb:P30487|uniprotkb:P30488|uniprotkb:P30489|uniprotkb:P30490|uniprotkb:P30491|uniprotkb:P30492|uniprotkb:P30493|uniprotkb:P30494|uniprotkb:P30495|uniprotkb:P30496|uniprotkb:P30497|uniprotkb:P30498|uniprotkb:P30513|uniprotkb:P30685|uniprotkb:P79489|uniprotkb:P79490|uniprotkb:P79496|uniprotkb:P79504|uniprotkb:P79523|uniprotkb:P79524|uniprotkb:P79555|uniprotkb:Q04826|uniprotkb:Q08136|uniprotkb:Q29633|uniprotkb:Q29636|uniprotkb:Q29638|uniprotkb:Q29661|uniprotkb:Q29665|uniprotkb:Q29678|uniprotkb:Q29679|uniprotkb:Q29681|uniprotkb:Q29935|uniprotkb:Q29936|uniprotkb:Q29940|uniprotkb:Q29953|uniprotkb:Q29961|uniprotkb:Q29982|intact:EBI-4289931|intact:EBI-7382650|intact:MINT-144207|intact:EBI-7245379|intact:MINT-1195012|intact:EBI-1059117|intact:EBI-4289845|uniprotkb:Q29854|uniprotkb:Q29855|uniprotkb:Q29857|uniprotkb:Q29858|uniprotkb:Q29861|uniprotkb:Q29924|uniprotkb:Q29925|uniprotkb:Q29933|uniprotkb:Q8MHN4|uniprotkb:Q30173|uniprotkb:Q30198|uniprotkb:Q31603|uniprotkb:Q31610|uniprotkb:Q31612|uniprotkb:Q31613|uniprotkb:Q546L8|uniprotkb:Q546M4|uniprotkb:Q5JP37|uniprotkb:Q5QT24|uniprotkb:Q5RIP1|uniprotkb:Q5SRJ2|uniprotkb:Q5TK76|uniprotkb:Q5TK77|uniprotkb:Q860I4|uniprotkb:Q861B5|uniprotkb:Q8HWF0|uniprotkb:Q8MGQ3|uniprotkb:Q8SNC5|uniprotkb:Q95343|uniprotkb:Q95344|uniprotkb:Q95365|uniprotkb:Q95392|uniprotkb:Q95HA3|uniprotkb:Q95HA8|uniprotkb:Q95HM9|uniprotkb:Q95IA6|uniprotkb:Q95IB8|uniprotkb:Q95IH5|uniprotkb:Q96IT9|uniprotkb:Q9BCM6|uniprotkb:Q9BCM7|uniprotkb:Q9BCM8|uniprotkb:Q9BD06|uniprotkb:Q9BD38|uniprotkb:Q9BD43|uniprotkb:Q9GIL3|uniprotkb:Q9GIM3|uniprotkb:Q9GIX1|uniprotkb:Q9GIY5|uniprotkb:Q9GIZ0|uniprotkb:Q9GIZ9|uniprotkb:Q9GJ00|uniprotkb:Q9GJ17|uniprotkb:Q9GJ23|uniprotkb:Q9GJ31|uniprotkb:Q9GJF0|uniprotkb:Q9GJM7|uniprotkb:Q9MX21|uniprotkb:Q9MY37|uniprotkb:Q9MY42|uniprotkb:Q9MY43|uniprotkb:Q9MY61|uniprotkb:Q9MY75|uniprotkb:Q9MY79|uniprotkb:Q9MY84|uniprotkb:Q9MY92|uniprotkb:Q9MY93|uniprotkb:Q9MY94|uniprotkb:Q9MYB8|uniprotkb:Q9MYC3|uniprotkb:Q9MYC7|uniprotkb:Q9MYG1|uniprotkb:Q9TP35|uniprotkb:Q9UQS8|uniprotkb:Q9TP36|uniprotkb:Q9TP37|uniprotkb:Q9TP95|uniprotkb:Q9TPQ7|uniprotkb:Q9TPQ9|uniprotkb:Q9TPR2|uniprotkb:Q9TPR4|uniprotkb:Q9TPS6|uniprotkb:Q9TPT2|uniprotkb:Q9TPT4|uniprotkb:Q9TPT6|uniprotkb:Q9TPV2|uniprotkb:Q9TQG1|uniprotkb:Q9TQH3|uniprotkb:Q9TQH7|uniprotkb:Q9TQH8|uniprotkb:Q9TQH9|uniprotkb:Q9TQN4|uniprotkb:Q9TQN6	intact:EBI-13916812|ensembl:ENSP00000477744|ensembl:ENSP00000478241|ensembl:ENSP00000479843|ensembl:ENSP00000480062|ensembl:ENSP00000481319|ensembl:ENSP00000481753|ensembl:ENSP00000483112|ensembl:ENSP00000483274|ensembl:ENSP00000484123|ensembl:ENSP00000491676|ensembl:ENSP00000492248|ensembl:ENSP00000492546|ensembl:ENSP00000494622|ensembl:ENSP00000494670|ensembl:ENSP00000495680|uniprotkb:Q6H2G7	psi-mi:hlab_human(display_long)|uniprotkb:Human leukocyte antigen B(gene name synonym)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:HLAB(gene name synonym)	psi-mi:ki2s4_human(display_long)|uniprotkb:KIR2DS4(gene name)|psi-mi:KIR2DS4(display_short)|uniprotkb:CD158I(gene name synonym)|uniprotkb:KKA3(gene name synonym)|uniprotkb:NKAT8(gene name synonym)|uniprotkb:CD158 antigen-like family member I(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 8(gene name synonym)|uniprotkb:P58 natural killer cell receptor clones CL-39/CL-17(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13917509|imex:IM-25681-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:2HJL|rcsb pdb:2NW3|rcsb pdb:2A83|rcsb pdb:2NX5|rcsb pdb:2RFX|rcsb pdb:2YPK|rcsb pdb:2YPL|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BW9|rcsb pdb:3BWA|rcsb pdb:3C9N|rcsb pdb:3CZF|rcsb pdb:3D18|rcsb pdb:3DTX|rcsb pdb:2AK4|rcsb pdb:3DX6|rcsb pdb:3DX7|rcsb pdb:2AXF|rcsb pdb:3DX8|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:3HCV|rcsb pdb:2AXG|rcsb pdb:2BSR|rcsb pdb:2BSS|rcsb pdb:2BST|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:3KPL|rcsb pdb:3KPM|rcsb pdb:3KPN|rcsb pdb:3KPO|rcsb pdb:3KPP|rcsb pdb:3KPQ|rcsb pdb:3KPR|rcsb pdb:3KPS|rcsb pdb:3KWW|rcsb pdb:3KXF|rcsb pdb:3L3D|rcsb pdb:2H6P|rcsb pdb:3L3G|rcsb pdb:3L3I|rcsb pdb:3L3J|rcsb pdb:3L3K|rcsb pdb:3LN5|rcsb pdb:3LV3|rcsb pdb:3MV7|rcsb pdb:3LKN|rcsb pdb:3LKO|rcsb pdb:3LKP|rcsb pdb:3MV8|rcsb pdb:3MV9|rcsb pdb:3SJV|rcsb pdb:3SKM|rcsb pdb:3SKO|rcsb pdb:3SPV|rcsb pdb:3UPR|rcsb pdb:3VCL|rcsb pdb:3VFS|rcsb pdb:3VFT|rcsb pdb:3VFU|rcsb pdb:3VFV|rcsb pdb:3VFW|rcsb pdb:3VH8|rcsb pdb:3VRI|rcsb pdb:3LKQ|rcsb pdb:3LKR|rcsb pdb:3LKS|rcsb pdb:3LN4|rcsb pdb:3VRJ|rcsb pdb:3W39|rcsb pdb:3WUW|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:3X13|rcsb pdb:3X14|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|interpro:IPR037055|rcsb pdb:1A1M|rcsb pdb:1A1N|interpro:IPR036179|rcsb pdb:1A1O|rcsb pdb:1A9B|rcsb pdb:1A9E|rcsb pdb:1AGB|rcsb pdb:1AGC|rcsb pdb:1AGD|rcsb pdb:1AGE|rcsb pdb:1AGF|rcsb pdb:1CG9|rcsb pdb:1E27|rcsb pdb:1E28|rcsb pdb:1HSA|rcsb pdb:1JGD|rcsb pdb:1JGE|rcsb pdb:1K5N|rcsb pdb:1M05|rcsb pdb:1M6O|rcsb pdb:1MI5|rcsb pdb:1N2R|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:1SYS|rcsb pdb:1SYV|rcsb pdb:1UXS|rcsb pdb:1UXW|rcsb pdb:1W0V|rcsb pdb:1W0W|rcsb pdb:1XH3|rcsb pdb:1XR8|rcsb pdb:1XR9|rcsb pdb:1ZHK|rcsb pdb:1ZHL|rcsb pdb:1ZSD|rcsb pdb:4JQV|rcsb pdb:4JQX|rcsb pdb:4LCY|rcsb pdb:4LNR|rcsb pdb:4MJI|rcsb pdb:4G9F|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PR5|rcsb pdb:4PRN|rcsb pdb:4QRP|rcsb pdb:4QRQ|rcsb pdb:4QRR|rcsb pdb:4QRS|rcsb pdb:4QRT|rcsb pdb:4QRU|rcsb pdb:4U1H|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1K|rcsb pdb:4U1L|rcsb pdb:4U1M|rcsb pdb:4U1N|rcsb pdb:4U1S|rcsb pdb:4XXC|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5EO0|rcsb pdb:5EO1|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5TXS|rcsb pdb:5U98|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:5IEH|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5IEK|rcsb pdb:5VUF|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5VWH|rcsb pdb:5VWJ|rcsb pdb:5VZ5|rcsb pdb:5WMN|rcsb pdb:5WMO|rcsb pdb:5WMP|rcsb pdb:5IM7|rcsb pdb:5WMQ|rcsb pdb:5WMR|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5INC|rcsb pdb:6AT5|rcsb pdb:6AVF|rcsb pdb:5IND|rcsb pdb:5T6W|rcsb pdb:6AVG|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6BJ8|rcsb pdb:6BXP|rcsb pdb:5T6X|rcsb pdb:6BXQ|rcsb pdb:5T6Y|rcsb pdb:6D29|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T|rcsb pdb:6MT3|rcsb pdb:6MT4|rcsb pdb:6MT5|rcsb pdb:6MT6|ensembl:ENSG00000234745(gene)|ensembl:ENST00000412585(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:6MTM|rcsb pdb:6P23|rcsb pdb:6P27|rcsb pdb:6P2C|rcsb pdb:6P2F|rcsb pdb:6P2S|rcsb pdb:6PYJ|rcsb pdb:6PYL|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6VMX|rcsb pdb:7LFZ|rcsb pdb:7LG0|rcsb pdb:7LGD|rcsb pdb:7LGT|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6MTL|refseq:NP_005505.2	ensembl:ENSG00000274406(gene)|ensembl:ENSG00000274947(gene)|ensembl:ENSG00000274957(gene)|ensembl:ENSG00000275353(gene)|ensembl:ENSG00000275731(gene)|ensembl:ENSG00000283870(gene)|ensembl:ENSG00000276154(gene)|ensembl:ENSG00000283882(gene)|ensembl:ENSG00000284264(gene)|ensembl:ENSG00000276395(gene)|ensembl:ENST00000611311(transcript)|ensembl:ENST00000612783(transcript)|ensembl:ENST00000613654(transcript)|ensembl:ENST00000614639(transcript)|ensembl:ENST00000617469(transcript)|ensembl:ENST00000617825(transcript)|ensembl:ENST00000619771(transcript)|ensembl:ENST00000620669(transcript)|ensembl:ENST00000621436(transcript)|ensembl:ENST00000638566(transcript)|ensembl:ENST00000640817(transcript)|ensembl:ENSG00000276634(gene)|ensembl:ENST00000640941(transcript)|ensembl:ENSG00000276885(gene)|ensembl:ENST00000642862(transcript)|ensembl:ENST00000644051(transcript)|ensembl:ENST00000644154(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0023029"(MHC class Ib protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3H8N|reactome:R-HSA-2172127|refseq:NP_001268900.1|refseq:NP_001268901.1|refseq:NP_036446.3	-	-	-	figure legend:Fig 5ii|comment:B4601 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:NlO2PZ/66RypUzj8Euht3hRq8H89606	rogid:3VgxxvBA5EkKvrqpyjzOu88pG649606	rigid:zZzbjztruOi6mSfSN7MN6SsdCQk	false	-	fc-igg tag:?-?|mutation causing an interaction:92-93|mutation causing an interaction:205-205	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P01889	uniprotkb:P43632	intact:EBI-1046513|ensembl:ENSP00000399168|uniprotkb:O62901|uniprotkb:O95730|uniprotkb:O98140|uniprotkb:P79542|uniprotkb:Q95369|uniprotkb:Q95J00|uniprotkb:Q9GJ20|uniprotkb:Q9MY78|uniprotkb:Q9MYF4|uniprotkb:Q9TQH6|uniprotkb:Q9TQM2|uniprotkb:Q9UQT0|intact:EBI-1049793|intact:EBI-6163549|intact:EBI-6163552|intact:EBI-6163582|intact:EBI-6163570|intact:EBI-6163579|intact:EBI-6163555|intact:EBI-9978548|intact:EBI-1047909|intact:EBI-8770324|uniprotkb:A0A2I6Q7B5|uniprotkb:B0V0B8|uniprotkb:G3GN01|uniprotkb:O02862|uniprotkb:O02956|uniprotkb:O02957|uniprotkb:O02960|uniprotkb:O19555|uniprotkb:O19556|uniprotkb:O19595|uniprotkb:O19615|uniprotkb:O19624|uniprotkb:O78163|uniprotkb:O78172|intact:EBI-1054175|uniprotkb:O19625|uniprotkb:O19627|uniprotkb:O19641|uniprotkb:O19651|uniprotkb:O19675|uniprotkb:O19692|uniprotkb:O19758|uniprotkb:O19779|uniprotkb:O19783|uniprotkb:O46702|uniprotkb:O62897|uniprotkb:O62915|uniprotkb:O62917|uniprotkb:O62919|uniprotkb:O77933|uniprotkb:O77959|uniprotkb:O78053|uniprotkb:O78138|uniprotkb:O78160|uniprotkb:O78173|uniprotkb:O78180|uniprotkb:O78217|uniprotkb:P01890|uniprotkb:P03989|uniprotkb:P10317|uniprotkb:P10318|uniprotkb:P10319|uniprotkb:P10320|uniprotkb:P18463|uniprotkb:P18464|uniprotkb:P18465|uniprotkb:P19373|uniprotkb:P30460|uniprotkb:P30461|uniprotkb:P30462|uniprotkb:P30463|uniprotkb:P30464|uniprotkb:P30465|uniprotkb:P30466|uniprotkb:P30467|uniprotkb:P30468|uniprotkb:P30469|uniprotkb:P30470|uniprotkb:P30471|uniprotkb:P30472|uniprotkb:P30473|uniprotkb:P30474|uniprotkb:P30475|uniprotkb:P30476|uniprotkb:P30477|uniprotkb:P30478|uniprotkb:P30479|uniprotkb:P30480|uniprotkb:P30481|uniprotkb:Q29693|uniprotkb:Q29695|uniprotkb:Q29697|uniprotkb:Q29718|uniprotkb:Q29742|uniprotkb:Q29749|uniprotkb:Q29762|uniprotkb:Q29764|uniprotkb:Q29829|uniprotkb:Q29836|uniprotkb:Q29842|uniprotkb:Q29845|uniprotkb:Q29846|uniprotkb:Q29847|uniprotkb:Q29848|uniprotkb:Q29850|uniprotkb:Q29851|uniprotkb:Q29852|uniprotkb:P30482|uniprotkb:P30483|uniprotkb:P30484|uniprotkb:P30485|uniprotkb:P30486|uniprotkb:P30487|uniprotkb:P30488|uniprotkb:P30489|uniprotkb:P30490|uniprotkb:P30491|uniprotkb:P30492|uniprotkb:P30493|uniprotkb:P30494|uniprotkb:P30495|uniprotkb:P30496|uniprotkb:P30497|uniprotkb:P30498|uniprotkb:P30513|uniprotkb:P30685|uniprotkb:P79489|uniprotkb:P79490|uniprotkb:P79496|uniprotkb:P79504|uniprotkb:P79523|uniprotkb:P79524|uniprotkb:P79555|uniprotkb:Q04826|uniprotkb:Q08136|uniprotkb:Q29633|uniprotkb:Q29636|uniprotkb:Q29638|uniprotkb:Q29661|uniprotkb:Q29665|uniprotkb:Q29678|uniprotkb:Q29679|uniprotkb:Q29681|uniprotkb:Q29935|uniprotkb:Q29936|uniprotkb:Q29940|uniprotkb:Q29953|uniprotkb:Q29961|uniprotkb:Q29982|intact:EBI-4289931|intact:EBI-7382650|intact:MINT-144207|intact:EBI-7245379|intact:MINT-1195012|intact:EBI-1059117|intact:EBI-4289845|uniprotkb:Q29854|uniprotkb:Q29855|uniprotkb:Q29857|uniprotkb:Q29858|uniprotkb:Q29861|uniprotkb:Q29924|uniprotkb:Q29925|uniprotkb:Q29933|uniprotkb:Q8MHN4|uniprotkb:Q30173|uniprotkb:Q30198|uniprotkb:Q31603|uniprotkb:Q31610|uniprotkb:Q31612|uniprotkb:Q31613|uniprotkb:Q546L8|uniprotkb:Q546M4|uniprotkb:Q5JP37|uniprotkb:Q5QT24|uniprotkb:Q5RIP1|uniprotkb:Q5SRJ2|uniprotkb:Q5TK76|uniprotkb:Q5TK77|uniprotkb:Q860I4|uniprotkb:Q861B5|uniprotkb:Q8HWF0|uniprotkb:Q8MGQ3|uniprotkb:Q8SNC5|uniprotkb:Q95343|uniprotkb:Q95344|uniprotkb:Q95365|uniprotkb:Q95392|uniprotkb:Q95HA3|uniprotkb:Q95HA8|uniprotkb:Q95HM9|uniprotkb:Q95IA6|uniprotkb:Q95IB8|uniprotkb:Q95IH5|uniprotkb:Q96IT9|uniprotkb:Q9BCM6|uniprotkb:Q9BCM7|uniprotkb:Q9BCM8|uniprotkb:Q9BD06|uniprotkb:Q9BD38|uniprotkb:Q9BD43|uniprotkb:Q9GIL3|uniprotkb:Q9GIM3|uniprotkb:Q9GIX1|uniprotkb:Q9GIY5|uniprotkb:Q9GIZ0|uniprotkb:Q9GIZ9|uniprotkb:Q9GJ00|uniprotkb:Q9GJ17|uniprotkb:Q9GJ23|uniprotkb:Q9GJ31|uniprotkb:Q9GJF0|uniprotkb:Q9GJM7|uniprotkb:Q9MX21|uniprotkb:Q9MY37|uniprotkb:Q9MY42|uniprotkb:Q9MY43|uniprotkb:Q9MY61|uniprotkb:Q9MY75|uniprotkb:Q9MY79|uniprotkb:Q9MY84|uniprotkb:Q9MY92|uniprotkb:Q9MY93|uniprotkb:Q9MY94|uniprotkb:Q9MYB8|uniprotkb:Q9MYC3|uniprotkb:Q9MYC7|uniprotkb:Q9MYG1|uniprotkb:Q9TP35|uniprotkb:Q9UQS8|uniprotkb:Q9TP36|uniprotkb:Q9TP37|uniprotkb:Q9TP95|uniprotkb:Q9TPQ7|uniprotkb:Q9TPQ9|uniprotkb:Q9TPR2|uniprotkb:Q9TPR4|uniprotkb:Q9TPS6|uniprotkb:Q9TPT2|uniprotkb:Q9TPT4|uniprotkb:Q9TPT6|uniprotkb:Q9TPV2|uniprotkb:Q9TQG1|uniprotkb:Q9TQH3|uniprotkb:Q9TQH7|uniprotkb:Q9TQH8|uniprotkb:Q9TQH9|uniprotkb:Q9TQN4|uniprotkb:Q9TQN6	intact:EBI-13916812|ensembl:ENSP00000477744|ensembl:ENSP00000478241|ensembl:ENSP00000479843|ensembl:ENSP00000480062|ensembl:ENSP00000481319|ensembl:ENSP00000481753|ensembl:ENSP00000483112|ensembl:ENSP00000483274|ensembl:ENSP00000484123|ensembl:ENSP00000491676|ensembl:ENSP00000492248|ensembl:ENSP00000492546|ensembl:ENSP00000494622|ensembl:ENSP00000494670|ensembl:ENSP00000495680|uniprotkb:Q6H2G7	psi-mi:hlab_human(display_long)|uniprotkb:Human leukocyte antigen B(gene name synonym)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:HLAB(gene name synonym)	psi-mi:ki2s4_human(display_long)|uniprotkb:KIR2DS4(gene name)|psi-mi:KIR2DS4(display_short)|uniprotkb:CD158I(gene name synonym)|uniprotkb:KKA3(gene name synonym)|uniprotkb:NKAT8(gene name synonym)|uniprotkb:CD158 antigen-like family member I(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 8(gene name synonym)|uniprotkb:P58 natural killer cell receptor clones CL-39/CL-17(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13917518|imex:IM-25681-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:2HJL|rcsb pdb:2NW3|rcsb pdb:2A83|rcsb pdb:2NX5|rcsb pdb:2RFX|rcsb pdb:2YPK|rcsb pdb:2YPL|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BW9|rcsb pdb:3BWA|rcsb pdb:3C9N|rcsb pdb:3CZF|rcsb pdb:3D18|rcsb pdb:3DTX|rcsb pdb:2AK4|rcsb pdb:3DX6|rcsb pdb:3DX7|rcsb pdb:2AXF|rcsb pdb:3DX8|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:3HCV|rcsb pdb:2AXG|rcsb pdb:2BSR|rcsb pdb:2BSS|rcsb pdb:2BST|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:3KPL|rcsb pdb:3KPM|rcsb pdb:3KPN|rcsb pdb:3KPO|rcsb pdb:3KPP|rcsb pdb:3KPQ|rcsb pdb:3KPR|rcsb pdb:3KPS|rcsb pdb:3KWW|rcsb pdb:3KXF|rcsb pdb:3L3D|rcsb pdb:2H6P|rcsb pdb:3L3G|rcsb pdb:3L3I|rcsb pdb:3L3J|rcsb pdb:3L3K|rcsb pdb:3LN5|rcsb pdb:3LV3|rcsb pdb:3MV7|rcsb pdb:3LKN|rcsb pdb:3LKO|rcsb pdb:3LKP|rcsb pdb:3MV8|rcsb pdb:3MV9|rcsb pdb:3SJV|rcsb pdb:3SKM|rcsb pdb:3SKO|rcsb pdb:3SPV|rcsb pdb:3UPR|rcsb pdb:3VCL|rcsb pdb:3VFS|rcsb pdb:3VFT|rcsb pdb:3VFU|rcsb pdb:3VFV|rcsb pdb:3VFW|rcsb pdb:3VH8|rcsb pdb:3VRI|rcsb pdb:3LKQ|rcsb pdb:3LKR|rcsb pdb:3LKS|rcsb pdb:3LN4|rcsb pdb:3VRJ|rcsb pdb:3W39|rcsb pdb:3WUW|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:3X13|rcsb pdb:3X14|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|interpro:IPR037055|rcsb pdb:1A1M|rcsb pdb:1A1N|interpro:IPR036179|rcsb pdb:1A1O|rcsb pdb:1A9B|rcsb pdb:1A9E|rcsb pdb:1AGB|rcsb pdb:1AGC|rcsb pdb:1AGD|rcsb pdb:1AGE|rcsb pdb:1AGF|rcsb pdb:1CG9|rcsb pdb:1E27|rcsb pdb:1E28|rcsb pdb:1HSA|rcsb pdb:1JGD|rcsb pdb:1JGE|rcsb pdb:1K5N|rcsb pdb:1M05|rcsb pdb:1M6O|rcsb pdb:1MI5|rcsb pdb:1N2R|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:1SYS|rcsb pdb:1SYV|rcsb pdb:1UXS|rcsb pdb:1UXW|rcsb pdb:1W0V|rcsb pdb:1W0W|rcsb pdb:1XH3|rcsb pdb:1XR8|rcsb pdb:1XR9|rcsb pdb:1ZHK|rcsb pdb:1ZHL|rcsb pdb:1ZSD|rcsb pdb:4JQV|rcsb pdb:4JQX|rcsb pdb:4LCY|rcsb pdb:4LNR|rcsb pdb:4MJI|rcsb pdb:4G9F|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PR5|rcsb pdb:4PRN|rcsb pdb:4QRP|rcsb pdb:4QRQ|rcsb pdb:4QRR|rcsb pdb:4QRS|rcsb pdb:4QRT|rcsb pdb:4QRU|rcsb pdb:4U1H|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1K|rcsb pdb:4U1L|rcsb pdb:4U1M|rcsb pdb:4U1N|rcsb pdb:4U1S|rcsb pdb:4XXC|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5EO0|rcsb pdb:5EO1|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5TXS|rcsb pdb:5U98|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:5IEH|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5IEK|rcsb pdb:5VUF|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5VWH|rcsb pdb:5VWJ|rcsb pdb:5VZ5|rcsb pdb:5WMN|rcsb pdb:5WMO|rcsb pdb:5WMP|rcsb pdb:5IM7|rcsb pdb:5WMQ|rcsb pdb:5WMR|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5INC|rcsb pdb:6AT5|rcsb pdb:6AVF|rcsb pdb:5IND|rcsb pdb:5T6W|rcsb pdb:6AVG|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6BJ8|rcsb pdb:6BXP|rcsb pdb:5T6X|rcsb pdb:6BXQ|rcsb pdb:5T6Y|rcsb pdb:6D29|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T|rcsb pdb:6MT3|rcsb pdb:6MT4|rcsb pdb:6MT5|rcsb pdb:6MT6|ensembl:ENSG00000234745(gene)|ensembl:ENST00000412585(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:6MTM|rcsb pdb:6P23|rcsb pdb:6P27|rcsb pdb:6P2C|rcsb pdb:6P2F|rcsb pdb:6P2S|rcsb pdb:6PYJ|rcsb pdb:6PYL|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6VMX|rcsb pdb:7LFZ|rcsb pdb:7LG0|rcsb pdb:7LGD|rcsb pdb:7LGT|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6MTL|refseq:NP_005505.2	ensembl:ENSG00000274406(gene)|ensembl:ENSG00000274947(gene)|ensembl:ENSG00000274957(gene)|ensembl:ENSG00000275353(gene)|ensembl:ENSG00000275731(gene)|ensembl:ENSG00000283870(gene)|ensembl:ENSG00000276154(gene)|ensembl:ENSG00000283882(gene)|ensembl:ENSG00000284264(gene)|ensembl:ENSG00000276395(gene)|ensembl:ENST00000611311(transcript)|ensembl:ENST00000612783(transcript)|ensembl:ENST00000613654(transcript)|ensembl:ENST00000614639(transcript)|ensembl:ENST00000617469(transcript)|ensembl:ENST00000617825(transcript)|ensembl:ENST00000619771(transcript)|ensembl:ENST00000620669(transcript)|ensembl:ENST00000621436(transcript)|ensembl:ENST00000638566(transcript)|ensembl:ENST00000640817(transcript)|ensembl:ENSG00000276634(gene)|ensembl:ENST00000640941(transcript)|ensembl:ENSG00000276885(gene)|ensembl:ENST00000642862(transcript)|ensembl:ENST00000644051(transcript)|ensembl:ENST00000644154(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0023029"(MHC class Ib protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3H8N|reactome:R-HSA-2172127|refseq:NP_001268900.1|refseq:NP_001268901.1|refseq:NP_036446.3	-	-	-	figure legend:Fig 5iii|comment:B7301 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:NlO2PZ/66RypUzj8Euht3hRq8H89606	rogid:3VgxxvBA5EkKvrqpyjzOu88pG649606	rigid:zZzbjztruOi6mSfSN7MN6SsdCQk	false	-	mutation causing an interaction:92-93|mutation causing an interaction:205-205|fc-igg tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q53YP1	uniprotkb:P43632	intact:EBI-13917186|uniprotkb:O62883|uniprotkb:O78060|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:P30503|uniprotkb:Q29743|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q9GIK8|uniprotkb:Q9TQB4	intact:EBI-13916812|ensembl:ENSP00000477744|ensembl:ENSP00000478241|ensembl:ENSP00000479843|ensembl:ENSP00000480062|ensembl:ENSP00000481319|ensembl:ENSP00000481753|ensembl:ENSP00000483112|ensembl:ENSP00000483274|ensembl:ENSP00000484123|ensembl:ENSP00000491676|ensembl:ENSP00000492248|ensembl:ENSP00000492546|ensembl:ENSP00000494622|ensembl:ENSP00000494670|ensembl:ENSP00000495680|uniprotkb:Q6H2G7	psi-mi:1c03_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)|uniprotkb:HLAC(gene name synonym)|uniprotkb:MHC class I antigen Cw*3(gene name synonym)	psi-mi:ki2s4_human(display_long)|uniprotkb:KIR2DS4(gene name)|psi-mi:KIR2DS4(display_short)|uniprotkb:CD158I(gene name synonym)|uniprotkb:KKA3(gene name synonym)|uniprotkb:NKAT8(gene name synonym)|uniprotkb:CD158 antigen-like family member I(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 8(gene name synonym)|uniprotkb:P58 natural killer cell receptor clones CL-39/CL-17(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13917527|imex:IM-25681-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0055038"(recycling endosome membrane)|uniprotkb:P10321(see-also)|rcsb pdb:1EFX|ensembl:ENST00000457903|ensembl:ENSP00000390851|ensembl:ENSG00000225691|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0009986"(cell surface)|go:"GO:0031901"(early endosome membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0000139"(Golgi membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0046977"(TAP binding)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0045087"(innate immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060337"(type I interferon signaling pathway)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR036179|interpro:IPR037055	ensembl:ENSG00000274406(gene)|ensembl:ENSG00000274947(gene)|ensembl:ENSG00000274957(gene)|ensembl:ENSG00000275353(gene)|ensembl:ENSG00000275731(gene)|ensembl:ENSG00000283870(gene)|ensembl:ENSG00000276154(gene)|ensembl:ENSG00000283882(gene)|ensembl:ENSG00000284264(gene)|ensembl:ENSG00000276395(gene)|ensembl:ENST00000611311(transcript)|ensembl:ENST00000612783(transcript)|ensembl:ENST00000613654(transcript)|ensembl:ENST00000614639(transcript)|ensembl:ENST00000617469(transcript)|ensembl:ENST00000617825(transcript)|ensembl:ENST00000619771(transcript)|ensembl:ENST00000620669(transcript)|ensembl:ENST00000621436(transcript)|ensembl:ENST00000638566(transcript)|ensembl:ENST00000640817(transcript)|ensembl:ENSG00000276634(gene)|ensembl:ENST00000640941(transcript)|ensembl:ENSG00000276885(gene)|ensembl:ENST00000642862(transcript)|ensembl:ENST00000644051(transcript)|ensembl:ENST00000644154(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0023029"(MHC class Ib protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3H8N|reactome:R-HSA-2172127|refseq:NP_001268900.1|refseq:NP_001268901.1|refseq:NP_036446.3	-	no-uniprot-update:|caution:"The protein could not be merged with EBI-1051396 because of some conflicts with the protein sequence (features which cannot be shifted)."	-	figure legend:Fig 5|comment:C0302, C0304 and C0303 alleles;all alleles showed similar binding.|comment:"I119L variant:dbSNP:rs1071649;  Y140S variant dbSNP:rs713032;  G115R variant   dbSNP:rs1131122"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2017/02/21	rogid:JFeUsl+FLKQrUF6Miog4kKzX3aE9606	rogid:3VgxxvBA5EkKvrqpyjzOu88pG649606	rigid:GBu7qCPMOCeunJ90YS11jHPeFjo	false	variant:115-115|variant:140-140,119-119	mutation causing an interaction:205-205|mutation causing an interaction:92-93|fc-igg tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P10321	uniprotkb:P43632	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	intact:EBI-13916812|ensembl:ENSP00000477744|ensembl:ENSP00000478241|ensembl:ENSP00000479843|ensembl:ENSP00000480062|ensembl:ENSP00000481319|ensembl:ENSP00000481753|ensembl:ENSP00000483112|ensembl:ENSP00000483274|ensembl:ENSP00000484123|ensembl:ENSP00000491676|ensembl:ENSP00000492248|ensembl:ENSP00000492546|ensembl:ENSP00000494622|ensembl:ENSP00000494670|ensembl:ENSP00000495680|uniprotkb:Q6H2G7	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:ki2s4_human(display_long)|uniprotkb:KIR2DS4(gene name)|psi-mi:KIR2DS4(display_short)|uniprotkb:CD158I(gene name synonym)|uniprotkb:KKA3(gene name synonym)|uniprotkb:NKAT8(gene name synonym)|uniprotkb:CD158 antigen-like family member I(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 8(gene name synonym)|uniprotkb:P58 natural killer cell receptor clones CL-39/CL-17(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13917546|imex:IM-25681-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	ensembl:ENSG00000274406(gene)|ensembl:ENSG00000274947(gene)|ensembl:ENSG00000274957(gene)|ensembl:ENSG00000275353(gene)|ensembl:ENSG00000275731(gene)|ensembl:ENSG00000283870(gene)|ensembl:ENSG00000276154(gene)|ensembl:ENSG00000283882(gene)|ensembl:ENSG00000284264(gene)|ensembl:ENSG00000276395(gene)|ensembl:ENST00000611311(transcript)|ensembl:ENST00000612783(transcript)|ensembl:ENST00000613654(transcript)|ensembl:ENST00000614639(transcript)|ensembl:ENST00000617469(transcript)|ensembl:ENST00000617825(transcript)|ensembl:ENST00000619771(transcript)|ensembl:ENST00000620669(transcript)|ensembl:ENST00000621436(transcript)|ensembl:ENST00000638566(transcript)|ensembl:ENST00000640817(transcript)|ensembl:ENSG00000276634(gene)|ensembl:ENST00000640941(transcript)|ensembl:ENSG00000276885(gene)|ensembl:ENST00000642862(transcript)|ensembl:ENST00000644051(transcript)|ensembl:ENST00000644154(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0023029"(MHC class Ib protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3H8N|reactome:R-HSA-2172127|refseq:NP_001268900.1|refseq:NP_001268901.1|refseq:NP_036446.3	-	-	-	figure legend:Fig 5|comment:C0702 allele;  weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	rogid:3VgxxvBA5EkKvrqpyjzOu88pG649606	rigid:KQr//PmhIgYcGeNbxrS9lUjifo4	false	-	fc-igg tag:?-?|mutation causing an interaction:92-93|mutation causing an interaction:205-205	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P10321	uniprotkb:P43632	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	intact:EBI-13916812|ensembl:ENSP00000477744|ensembl:ENSP00000478241|ensembl:ENSP00000479843|ensembl:ENSP00000480062|ensembl:ENSP00000481319|ensembl:ENSP00000481753|ensembl:ENSP00000483112|ensembl:ENSP00000483274|ensembl:ENSP00000484123|ensembl:ENSP00000491676|ensembl:ENSP00000492248|ensembl:ENSP00000492546|ensembl:ENSP00000494622|ensembl:ENSP00000494670|ensembl:ENSP00000495680|uniprotkb:Q6H2G7	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:ki2s4_human(display_long)|uniprotkb:KIR2DS4(gene name)|psi-mi:KIR2DS4(display_short)|uniprotkb:CD158I(gene name synonym)|uniprotkb:KKA3(gene name synonym)|uniprotkb:NKAT8(gene name synonym)|uniprotkb:CD158 antigen-like family member I(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 8(gene name synonym)|uniprotkb:P58 natural killer cell receptor clones CL-39/CL-17(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13917559|imex:IM-25681-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	ensembl:ENSG00000274406(gene)|ensembl:ENSG00000274947(gene)|ensembl:ENSG00000274957(gene)|ensembl:ENSG00000275353(gene)|ensembl:ENSG00000275731(gene)|ensembl:ENSG00000283870(gene)|ensembl:ENSG00000276154(gene)|ensembl:ENSG00000283882(gene)|ensembl:ENSG00000284264(gene)|ensembl:ENSG00000276395(gene)|ensembl:ENST00000611311(transcript)|ensembl:ENST00000612783(transcript)|ensembl:ENST00000613654(transcript)|ensembl:ENST00000614639(transcript)|ensembl:ENST00000617469(transcript)|ensembl:ENST00000617825(transcript)|ensembl:ENST00000619771(transcript)|ensembl:ENST00000620669(transcript)|ensembl:ENST00000621436(transcript)|ensembl:ENST00000638566(transcript)|ensembl:ENST00000640817(transcript)|ensembl:ENSG00000276634(gene)|ensembl:ENST00000640941(transcript)|ensembl:ENSG00000276885(gene)|ensembl:ENST00000642862(transcript)|ensembl:ENST00000644051(transcript)|ensembl:ENST00000644154(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0023029"(MHC class Ib protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3H8N|reactome:R-HSA-2172127|refseq:NP_001268900.1|refseq:NP_001268901.1|refseq:NP_036446.3	-	-	-	figure legend:Fig 5|comment:C0801 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	rogid:3VgxxvBA5EkKvrqpyjzOu88pG649606	rigid:KQr//PmhIgYcGeNbxrS9lUjifo4	false	-	mutation causing an interaction:92-93|mutation causing an interaction:205-205|fc-igg tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P43626	uniprotkb:P10321	intact:EBI-8684277|uniprotkb:Q6IST4|intact:MINT-8013645|uniprotkb:Q32WE6|uniprotkb:O43470|ensembl:ENSP00000478232|ensembl:ENSP00000478263|ensembl:ENSP00000479363|ensembl:ENSP00000482120|ensembl:ENSP00000484361|ensembl:ENSP00000484559|ensembl:ENSP00000291633	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	psi-mi:ki2l1_human(display_long)|uniprotkb:KIR2DL1(gene name)|psi-mi:KIR2DL1(display_short)|uniprotkb:CD158 antigen-like family member A(gene name synonym)|uniprotkb:CD158A(gene name synonym)|uniprotkb:NKAT1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 1(gene name synonym)|uniprotkb:p58 natural killer cell receptor clones CL-42/47.11(gene name synonym)|uniprotkb:p58.1 MHC class-I-specific NK receptor(gene name synonym)	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13917653|imex:IM-25681-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055033.2|ensembl:ENSG00000125498(gene)|ensembl:ENSG00000273794(gene)|ensembl:ENSG00000276625(gene)|ensembl:ENSG00000277833(gene)|ensembl:ENSG00000278495(gene)|ensembl:ENSG00000278738(gene)|ensembl:ENSG00000278821(gene)|ensembl:ENST00000291633(transcript)|ensembl:ENST00000611611(transcript)|ensembl:ENST00000615920(transcript)|ensembl:ENST00000617376(transcript)|ensembl:ENST00000618563(transcript)|ensembl:ENST00000620449(transcript)|ensembl:ENST00000622463(transcript)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IM9|rcsb pdb:1NKR|reactome:R-HSA-198933	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	-	comment:mint	-	figure legend:Fig 1,  Supp Fig 3-1|comment:C1802 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:8lycFqdUAUK1Ww2NpLHNFtFPlZ49606	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	rigid:P0WYRZRAbNwTALcykoeA5rWQ8b8	false	mutation decreasing interaction strength:92-93|variant:37-37,135-135|fc-igg tag:?-?|mutation increasing interaction strength:92-92|mutation decreasing interaction strength:105-105|mutation decreasing interaction strength:92-93,105-105	variant:272-272	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P43626	uniprotkb:P10321	intact:EBI-8684277|uniprotkb:Q6IST4|intact:MINT-8013645|uniprotkb:Q32WE6|uniprotkb:O43470|ensembl:ENSP00000478232|ensembl:ENSP00000478263|ensembl:ENSP00000479363|ensembl:ENSP00000482120|ensembl:ENSP00000484361|ensembl:ENSP00000484559|ensembl:ENSP00000291633	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	psi-mi:ki2l1_human(display_long)|uniprotkb:KIR2DL1(gene name)|psi-mi:KIR2DL1(display_short)|uniprotkb:CD158 antigen-like family member A(gene name synonym)|uniprotkb:CD158A(gene name synonym)|uniprotkb:NKAT1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 1(gene name synonym)|uniprotkb:p58 natural killer cell receptor clones CL-42/47.11(gene name synonym)|uniprotkb:p58.1 MHC class-I-specific NK receptor(gene name synonym)	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13917738|imex:IM-25681-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055033.2|ensembl:ENSG00000125498(gene)|ensembl:ENSG00000273794(gene)|ensembl:ENSG00000276625(gene)|ensembl:ENSG00000277833(gene)|ensembl:ENSG00000278495(gene)|ensembl:ENSG00000278738(gene)|ensembl:ENSG00000278821(gene)|ensembl:ENST00000291633(transcript)|ensembl:ENST00000611611(transcript)|ensembl:ENST00000615920(transcript)|ensembl:ENST00000617376(transcript)|ensembl:ENST00000618563(transcript)|ensembl:ENST00000620449(transcript)|ensembl:ENST00000622463(transcript)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IM9|rcsb pdb:1NKR|reactome:R-HSA-198933	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	-	comment:mint	-	figure legend:Fig 1,  Supp Fig 3-2|comment:C1701 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:8lycFqdUAUK1Ww2NpLHNFtFPlZ49606	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	rigid:P0WYRZRAbNwTALcykoeA5rWQ8b8	false	variant:37-37,135-135|mutation decreasing interaction strength:92-93|fc-igg tag:?-?|mutation decreasing interaction strength:92-92|mutation decreasing interaction strength:105-105|mutation decreasing interaction strength:92-93,105-105	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P43626	uniprotkb:P10321	intact:EBI-8684277|uniprotkb:Q6IST4|intact:MINT-8013645|uniprotkb:Q32WE6|uniprotkb:O43470|ensembl:ENSP00000478232|ensembl:ENSP00000478263|ensembl:ENSP00000479363|ensembl:ENSP00000482120|ensembl:ENSP00000484361|ensembl:ENSP00000484559|ensembl:ENSP00000291633	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	psi-mi:ki2l1_human(display_long)|uniprotkb:KIR2DL1(gene name)|psi-mi:KIR2DL1(display_short)|uniprotkb:CD158 antigen-like family member A(gene name synonym)|uniprotkb:CD158A(gene name synonym)|uniprotkb:NKAT1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 1(gene name synonym)|uniprotkb:p58 natural killer cell receptor clones CL-42/47.11(gene name synonym)|uniprotkb:p58.1 MHC class-I-specific NK receptor(gene name synonym)	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13917756|imex:IM-25681-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055033.2|ensembl:ENSG00000125498(gene)|ensembl:ENSG00000273794(gene)|ensembl:ENSG00000276625(gene)|ensembl:ENSG00000277833(gene)|ensembl:ENSG00000278495(gene)|ensembl:ENSG00000278738(gene)|ensembl:ENSG00000278821(gene)|ensembl:ENST00000291633(transcript)|ensembl:ENST00000611611(transcript)|ensembl:ENST00000615920(transcript)|ensembl:ENST00000617376(transcript)|ensembl:ENST00000618563(transcript)|ensembl:ENST00000620449(transcript)|ensembl:ENST00000622463(transcript)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IM9|rcsb pdb:1NKR|reactome:R-HSA-198933	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	-	comment:mint	-	figure legend:Fig 1,  Supp Fig 3-3|comment:C1502 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:8lycFqdUAUK1Ww2NpLHNFtFPlZ49606	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	rigid:P0WYRZRAbNwTALcykoeA5rWQ8b8	false	mutation decreasing interaction strength:92-93|fc-igg tag:?-?|mutation increasing interaction strength:92-92|mutation decreasing interaction strength:105-105|mutation decreasing interaction strength:92-93,105-105|variant:37-37,135-135	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P43626	uniprotkb:P10321	intact:EBI-8684277|uniprotkb:Q6IST4|intact:MINT-8013645|uniprotkb:Q32WE6|uniprotkb:O43470|ensembl:ENSP00000478232|ensembl:ENSP00000478263|ensembl:ENSP00000479363|ensembl:ENSP00000482120|ensembl:ENSP00000484361|ensembl:ENSP00000484559|ensembl:ENSP00000291633	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	psi-mi:ki2l1_human(display_long)|uniprotkb:KIR2DL1(gene name)|psi-mi:KIR2DL1(display_short)|uniprotkb:CD158 antigen-like family member A(gene name synonym)|uniprotkb:CD158A(gene name synonym)|uniprotkb:NKAT1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 1(gene name synonym)|uniprotkb:p58 natural killer cell receptor clones CL-42/47.11(gene name synonym)|uniprotkb:p58.1 MHC class-I-specific NK receptor(gene name synonym)	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13917772|imex:IM-25681-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055033.2|ensembl:ENSG00000125498(gene)|ensembl:ENSG00000273794(gene)|ensembl:ENSG00000276625(gene)|ensembl:ENSG00000277833(gene)|ensembl:ENSG00000278495(gene)|ensembl:ENSG00000278738(gene)|ensembl:ENSG00000278821(gene)|ensembl:ENST00000291633(transcript)|ensembl:ENST00000611611(transcript)|ensembl:ENST00000615920(transcript)|ensembl:ENST00000617376(transcript)|ensembl:ENST00000618563(transcript)|ensembl:ENST00000620449(transcript)|ensembl:ENST00000622463(transcript)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IM9|rcsb pdb:1NKR|reactome:R-HSA-198933	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	-	comment:mint	-	figure legend:Fig 1,  Supp Fig 3-4|comment:C0602 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:8lycFqdUAUK1Ww2NpLHNFtFPlZ49606	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	rigid:P0WYRZRAbNwTALcykoeA5rWQ8b8	false	variant:37-37,135-135|mutation decreasing interaction strength:92-93|fc-igg tag:?-?|mutation increasing interaction strength:92-92|mutation decreasing interaction strength:105-105|mutation decreasing interaction strength:92-93,105-105	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P43626	uniprotkb:P10321	intact:EBI-8684277|uniprotkb:Q6IST4|intact:MINT-8013645|uniprotkb:Q32WE6|uniprotkb:O43470|ensembl:ENSP00000478232|ensembl:ENSP00000478263|ensembl:ENSP00000479363|ensembl:ENSP00000482120|ensembl:ENSP00000484361|ensembl:ENSP00000484559|ensembl:ENSP00000291633	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	psi-mi:ki2l1_human(display_long)|uniprotkb:KIR2DL1(gene name)|psi-mi:KIR2DL1(display_short)|uniprotkb:CD158 antigen-like family member A(gene name synonym)|uniprotkb:CD158A(gene name synonym)|uniprotkb:NKAT1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 1(gene name synonym)|uniprotkb:p58 natural killer cell receptor clones CL-42/47.11(gene name synonym)|uniprotkb:p58.1 MHC class-I-specific NK receptor(gene name synonym)	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13917788|imex:IM-25681-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055033.2|ensembl:ENSG00000125498(gene)|ensembl:ENSG00000273794(gene)|ensembl:ENSG00000276625(gene)|ensembl:ENSG00000277833(gene)|ensembl:ENSG00000278495(gene)|ensembl:ENSG00000278738(gene)|ensembl:ENSG00000278821(gene)|ensembl:ENST00000291633(transcript)|ensembl:ENST00000611611(transcript)|ensembl:ENST00000615920(transcript)|ensembl:ENST00000617376(transcript)|ensembl:ENST00000618563(transcript)|ensembl:ENST00000620449(transcript)|ensembl:ENST00000622463(transcript)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IM9|rcsb pdb:1NKR|reactome:R-HSA-198933	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	-	comment:mint	-	figure legend:Fig 1,  Supp Fig 3-5|comment:C0501 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:8lycFqdUAUK1Ww2NpLHNFtFPlZ49606	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	rigid:P0WYRZRAbNwTALcykoeA5rWQ8b8	false	variant:37-37,135-135|mutation decreasing interaction strength:92-93|fc-igg tag:?-?|mutation increasing interaction strength:92-92|mutation decreasing interaction strength:105-105|mutation decreasing interaction strength:92-93,105-105	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P43626	uniprotkb:P10321	intact:EBI-8684277|uniprotkb:Q6IST4|intact:MINT-8013645|uniprotkb:Q32WE6|uniprotkb:O43470|ensembl:ENSP00000478232|ensembl:ENSP00000478263|ensembl:ENSP00000479363|ensembl:ENSP00000482120|ensembl:ENSP00000484361|ensembl:ENSP00000484559|ensembl:ENSP00000291633	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	psi-mi:ki2l1_human(display_long)|uniprotkb:KIR2DL1(gene name)|psi-mi:KIR2DL1(display_short)|uniprotkb:CD158 antigen-like family member A(gene name synonym)|uniprotkb:CD158A(gene name synonym)|uniprotkb:NKAT1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 1(gene name synonym)|uniprotkb:p58 natural killer cell receptor clones CL-42/47.11(gene name synonym)|uniprotkb:p58.1 MHC class-I-specific NK receptor(gene name synonym)	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13917804|imex:IM-25681-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055033.2|ensembl:ENSG00000125498(gene)|ensembl:ENSG00000273794(gene)|ensembl:ENSG00000276625(gene)|ensembl:ENSG00000277833(gene)|ensembl:ENSG00000278495(gene)|ensembl:ENSG00000278738(gene)|ensembl:ENSG00000278821(gene)|ensembl:ENST00000291633(transcript)|ensembl:ENST00000611611(transcript)|ensembl:ENST00000615920(transcript)|ensembl:ENST00000617376(transcript)|ensembl:ENST00000618563(transcript)|ensembl:ENST00000620449(transcript)|ensembl:ENST00000622463(transcript)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IM9|rcsb pdb:1NKR|reactome:R-HSA-198933	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	-	comment:mint	-	figure legend:Fig 1,  Supp Fig 3-6|comment:C0401 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:8lycFqdUAUK1Ww2NpLHNFtFPlZ49606	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	rigid:P0WYRZRAbNwTALcykoeA5rWQ8b8	false	mutation decreasing interaction strength:92-93|fc-igg tag:?-?|mutation increasing interaction strength:92-92|mutation decreasing interaction strength:105-105|mutation decreasing interaction strength:92-93,105-105|variant:37-37,135-135	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P43626	uniprotkb:A0A583ZBW8	intact:EBI-8684277|uniprotkb:Q6IST4|intact:MINT-8013645|uniprotkb:Q32WE6|uniprotkb:O43470|ensembl:ENSP00000478232|ensembl:ENSP00000478263|ensembl:ENSP00000479363|ensembl:ENSP00000482120|ensembl:ENSP00000484361|ensembl:ENSP00000484559|ensembl:ENSP00000291633	intact:EBI-9978392|uniprotkb:P30502	psi-mi:ki2l1_human(display_long)|uniprotkb:KIR2DL1(gene name)|psi-mi:KIR2DL1(display_short)|uniprotkb:CD158 antigen-like family member A(gene name synonym)|uniprotkb:CD158A(gene name synonym)|uniprotkb:NKAT1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 1(gene name synonym)|uniprotkb:p58 natural killer cell receptor clones CL-42/47.11(gene name synonym)|uniprotkb:p58.1 MHC class-I-specific NK receptor(gene name synonym)	psi-mi:1c02_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)|uniprotkb:HLAC(gene name synonym)|uniprotkb:MHC class I antigen Cw*2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13917820|imex:IM-25681-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055033.2|ensembl:ENSG00000125498(gene)|ensembl:ENSG00000273794(gene)|ensembl:ENSG00000276625(gene)|ensembl:ENSG00000277833(gene)|ensembl:ENSG00000278495(gene)|ensembl:ENSG00000278738(gene)|ensembl:ENSG00000278821(gene)|ensembl:ENST00000291633(transcript)|ensembl:ENST00000611611(transcript)|ensembl:ENST00000615920(transcript)|ensembl:ENST00000617376(transcript)|ensembl:ENST00000618563(transcript)|ensembl:ENST00000620449(transcript)|ensembl:ENST00000622463(transcript)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IM9|rcsb pdb:1NKR|reactome:R-HSA-198933	go:"GO:0055038"(recycling endosome membrane)|uniprotkb:P10321(see-also)|go:"GO:0009986"(cell surface)|go:"GO:0031901"(early endosome membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0000139"(Golgi membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0046977"(TAP binding)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060337"(type I interferon signaling pathway)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|ensembl:ENST00000420206|ensembl:ENSP00000410214|ensembl:ENSG00000228299|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|interpro:IPR036179|interpro:IPR037055|uniprotkb:A0A0B7NNJ6(see-also)	-	comment:mint	no-uniprot-update:|caution:"The protein could not be merged with EBI-1051396 because of some conflicts with the protein sequence (features which cannot be shifted)."	figure legend:Fig 1,  Supp Fig 3-7|comment:C0202 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2017/02/21	rogid:8lycFqdUAUK1Ww2NpLHNFtFPlZ49606	rogid:to6Sq6pB+Vn5nSM0v5vkRoYCpqk9606	rigid:b3VbTkIPOyEA9w1WhtJ0XpxuK0Y	false	mutation decreasing interaction strength:92-93|fc-igg tag:?-?|mutation increasing interaction strength:92-92|mutation decreasing interaction strength:105-105|mutation decreasing interaction strength:92-93,105-105|variant:37-37,135-135	variant:5-5|variant:10-10|variant:73-74|variant:92-92|variant:179-179|variant:202-202|variant:364-364	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P43628	uniprotkb:P10321	intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym)	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13917851|imex:IM-25681-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	-	comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis"	-	figure legend:Fig 1,  Supp Fig 3-19|comment:C0201 allele;weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	rigid:C9rNEX6KgOloPayGCJms4nYW+M4	false	mutation decreasing interaction strength:92-93|fc-igg tag:?-?|mutation increasing interaction strength:92-92|mutation decreasing interaction strength:105-105|mutation decreasing interaction strength:92-93,105-105	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P43628	uniprotkb:P10321	intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym)	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13918247|imex:IM-25681-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	-	comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis"	-	figure legend:Fig 1,  Supp Fig 3-8|comment:C1601|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	rigid:C9rNEX6KgOloPayGCJms4nYW+M4	false	mutation disrupting interaction strength:92-93|fc-igg tag:?-?|mutation increasing interaction strength:92-92|mutation disrupting interaction strength:105-105|mutation disrupting interaction strength:92-93,105-105	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P43628	uniprotkb:P10321	intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym)	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13918264|imex:IM-25681-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	-	comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis"	-	figure legend:Fig 1,  Supp Fig 3-9|comment:C0801|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	rigid:C9rNEX6KgOloPayGCJms4nYW+M4	false	mutation disrupting interaction strength:92-93|fc-igg tag:?-?|mutation increasing interaction strength:92-92|mutation disrupting interaction strength:105-105|mutation disrupting interaction strength:92-93,105-105	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P43628	uniprotkb:P10321	intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym)	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13918280|imex:IM-25681-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	-	comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis"	-	figure legend:Fig 1,  Supp Fig 3-10|comment:C0702|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	rigid:C9rNEX6KgOloPayGCJms4nYW+M4	false	mutation disrupting interaction strength:92-93|fc-igg tag:?-?|mutation increasing interaction strength:92-92|mutation disrupting interaction strength:105-105|mutation disrupting interaction strength:92-93,105-105	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P43628	uniprotkb:Q53YP1	intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472	intact:EBI-13917186|uniprotkb:O62883|uniprotkb:O78060|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:P30503|uniprotkb:Q29743|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q9GIK8|uniprotkb:Q9TQB4	psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym)	psi-mi:1c03_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)|uniprotkb:HLAC(gene name synonym)|uniprotkb:MHC class I antigen Cw*3(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13918296|imex:IM-25681-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2	go:"GO:0055038"(recycling endosome membrane)|uniprotkb:P10321(see-also)|rcsb pdb:1EFX|ensembl:ENST00000457903|ensembl:ENSP00000390851|ensembl:ENSG00000225691|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0009986"(cell surface)|go:"GO:0031901"(early endosome membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0000139"(Golgi membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0046977"(TAP binding)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0045087"(innate immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060337"(type I interferon signaling pathway)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR036179|interpro:IPR037055	-	comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis"	no-uniprot-update:|caution:"The protein could not be merged with EBI-1051396 because of some conflicts with the protein sequence (features which cannot be shifted)."	figure legend:Fig 1,  Supp Fig 3-11|comment:C0304 and C0302  alleles;both show same results|comment:"I119L variant:dbSNP:rs1071649; Y140S variant dbSNP:rs713032; G115R variant dbSNP:rs1131122"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2017/02/22	rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606	rogid:JFeUsl+FLKQrUF6Miog4kKzX3aE9606	rigid:eAZI2fYd2Rmch8BHf86qsIX3DU8	false	mutation disrupting interaction strength:92-93|fc-igg tag:?-?|mutation decreasing interaction strength:92-92|mutation disrupting interaction strength:105-105|mutation disrupting interaction strength:92-93,105-105	variant:119-119|variant:140-140	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P43628	uniprotkb:P10321	intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym)	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13918317|imex:IM-25681-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	-	comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis"	-	figure legend:Fig 1,  Supp Fig 3-12|comment:C0303  allele|comment:"G115R variant dbSNP:rs1131122"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	rigid:C9rNEX6KgOloPayGCJms4nYW+M4	false	mutation disrupting interaction strength:92-93|fc-igg tag:?-?|mutation increasing interaction strength:92-92|mutation disrupting interaction strength:105-105|mutation disrupting interaction strength:92-93,105-105	variant:115-115	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P43628	uniprotkb:A0A583ZBW7	intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472	intact:EBI-13916865|uniprotkb:O02865|uniprotkb:O19676|uniprotkb:P30500|uniprotkb:Q29986|uniprotkb:Q9UQS9	psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym)	psi-mi:1c01_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)|uniprotkb:HLAC(gene name synonym)|uniprotkb:MHC class I antigen Cw*1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13918340|imex:IM-25681-34	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2	go:"GO:0055038"(recycling endosome membrane)|uniprotkb:P10321(see-also)|ensembl:ENST00000438171|ensembl:ENSP00000393374|ensembl:ENSG00000237022|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0009986"(cell surface)|go:"GO:0031901"(early endosome membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0000139"(Golgi membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0046977"(TAP binding)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060337"(type I interferon signaling pathway)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR036179|interpro:IPR037055	-	comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis"	no-uniprot-update:|caution:"The protein could not be merged with EBI-1051396 because of some conflicts with the protein sequence (features which cannot be shifted)."	figure legend:Fig 1,  Supp Fig 3-14|comment:C0102  allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2017/02/22	rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606	rogid:yZNtsKoOb6HhKK3W3XprXxlPin09606	rigid:EZxbqQ1S010JTXr8MBZf0SgrvcU	false	fc-igg tag:?-?|mutation decreasing interaction strength:92-92	variant:5-5|variant:92-92|variant:179-179|variant:202-202|variant:364-364	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P43628	uniprotkb:P01889	intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472	intact:EBI-1046513|ensembl:ENSP00000399168|uniprotkb:O62901|uniprotkb:O95730|uniprotkb:O98140|uniprotkb:P79542|uniprotkb:Q95369|uniprotkb:Q95J00|uniprotkb:Q9GJ20|uniprotkb:Q9MY78|uniprotkb:Q9MYF4|uniprotkb:Q9TQH6|uniprotkb:Q9TQM2|uniprotkb:Q9UQT0|intact:EBI-1049793|intact:EBI-6163549|intact:EBI-6163552|intact:EBI-6163582|intact:EBI-6163570|intact:EBI-6163579|intact:EBI-6163555|intact:EBI-9978548|intact:EBI-1047909|intact:EBI-8770324|uniprotkb:A0A2I6Q7B5|uniprotkb:B0V0B8|uniprotkb:G3GN01|uniprotkb:O02862|uniprotkb:O02956|uniprotkb:O02957|uniprotkb:O02960|uniprotkb:O19555|uniprotkb:O19556|uniprotkb:O19595|uniprotkb:O19615|uniprotkb:O19624|uniprotkb:O78163|uniprotkb:O78172|intact:EBI-1054175|uniprotkb:O19625|uniprotkb:O19627|uniprotkb:O19641|uniprotkb:O19651|uniprotkb:O19675|uniprotkb:O19692|uniprotkb:O19758|uniprotkb:O19779|uniprotkb:O19783|uniprotkb:O46702|uniprotkb:O62897|uniprotkb:O62915|uniprotkb:O62917|uniprotkb:O62919|uniprotkb:O77933|uniprotkb:O77959|uniprotkb:O78053|uniprotkb:O78138|uniprotkb:O78160|uniprotkb:O78173|uniprotkb:O78180|uniprotkb:O78217|uniprotkb:P01890|uniprotkb:P03989|uniprotkb:P10317|uniprotkb:P10318|uniprotkb:P10319|uniprotkb:P10320|uniprotkb:P18463|uniprotkb:P18464|uniprotkb:P18465|uniprotkb:P19373|uniprotkb:P30460|uniprotkb:P30461|uniprotkb:P30462|uniprotkb:P30463|uniprotkb:P30464|uniprotkb:P30465|uniprotkb:P30466|uniprotkb:P30467|uniprotkb:P30468|uniprotkb:P30469|uniprotkb:P30470|uniprotkb:P30471|uniprotkb:P30472|uniprotkb:P30473|uniprotkb:P30474|uniprotkb:P30475|uniprotkb:P30476|uniprotkb:P30477|uniprotkb:P30478|uniprotkb:P30479|uniprotkb:P30480|uniprotkb:P30481|uniprotkb:Q29693|uniprotkb:Q29695|uniprotkb:Q29697|uniprotkb:Q29718|uniprotkb:Q29742|uniprotkb:Q29749|uniprotkb:Q29762|uniprotkb:Q29764|uniprotkb:Q29829|uniprotkb:Q29836|uniprotkb:Q29842|uniprotkb:Q29845|uniprotkb:Q29846|uniprotkb:Q29847|uniprotkb:Q29848|uniprotkb:Q29850|uniprotkb:Q29851|uniprotkb:Q29852|uniprotkb:P30482|uniprotkb:P30483|uniprotkb:P30484|uniprotkb:P30485|uniprotkb:P30486|uniprotkb:P30487|uniprotkb:P30488|uniprotkb:P30489|uniprotkb:P30490|uniprotkb:P30491|uniprotkb:P30492|uniprotkb:P30493|uniprotkb:P30494|uniprotkb:P30495|uniprotkb:P30496|uniprotkb:P30497|uniprotkb:P30498|uniprotkb:P30513|uniprotkb:P30685|uniprotkb:P79489|uniprotkb:P79490|uniprotkb:P79496|uniprotkb:P79504|uniprotkb:P79523|uniprotkb:P79524|uniprotkb:P79555|uniprotkb:Q04826|uniprotkb:Q08136|uniprotkb:Q29633|uniprotkb:Q29636|uniprotkb:Q29638|uniprotkb:Q29661|uniprotkb:Q29665|uniprotkb:Q29678|uniprotkb:Q29679|uniprotkb:Q29681|uniprotkb:Q29935|uniprotkb:Q29936|uniprotkb:Q29940|uniprotkb:Q29953|uniprotkb:Q29961|uniprotkb:Q29982|intact:EBI-4289931|intact:EBI-7382650|intact:MINT-144207|intact:EBI-7245379|intact:MINT-1195012|intact:EBI-1059117|intact:EBI-4289845|uniprotkb:Q29854|uniprotkb:Q29855|uniprotkb:Q29857|uniprotkb:Q29858|uniprotkb:Q29861|uniprotkb:Q29924|uniprotkb:Q29925|uniprotkb:Q29933|uniprotkb:Q8MHN4|uniprotkb:Q30173|uniprotkb:Q30198|uniprotkb:Q31603|uniprotkb:Q31610|uniprotkb:Q31612|uniprotkb:Q31613|uniprotkb:Q546L8|uniprotkb:Q546M4|uniprotkb:Q5JP37|uniprotkb:Q5QT24|uniprotkb:Q5RIP1|uniprotkb:Q5SRJ2|uniprotkb:Q5TK76|uniprotkb:Q5TK77|uniprotkb:Q860I4|uniprotkb:Q861B5|uniprotkb:Q8HWF0|uniprotkb:Q8MGQ3|uniprotkb:Q8SNC5|uniprotkb:Q95343|uniprotkb:Q95344|uniprotkb:Q95365|uniprotkb:Q95392|uniprotkb:Q95HA3|uniprotkb:Q95HA8|uniprotkb:Q95HM9|uniprotkb:Q95IA6|uniprotkb:Q95IB8|uniprotkb:Q95IH5|uniprotkb:Q96IT9|uniprotkb:Q9BCM6|uniprotkb:Q9BCM7|uniprotkb:Q9BCM8|uniprotkb:Q9BD06|uniprotkb:Q9BD38|uniprotkb:Q9BD43|uniprotkb:Q9GIL3|uniprotkb:Q9GIM3|uniprotkb:Q9GIX1|uniprotkb:Q9GIY5|uniprotkb:Q9GIZ0|uniprotkb:Q9GIZ9|uniprotkb:Q9GJ00|uniprotkb:Q9GJ17|uniprotkb:Q9GJ23|uniprotkb:Q9GJ31|uniprotkb:Q9GJF0|uniprotkb:Q9GJM7|uniprotkb:Q9MX21|uniprotkb:Q9MY37|uniprotkb:Q9MY42|uniprotkb:Q9MY43|uniprotkb:Q9MY61|uniprotkb:Q9MY75|uniprotkb:Q9MY79|uniprotkb:Q9MY84|uniprotkb:Q9MY92|uniprotkb:Q9MY93|uniprotkb:Q9MY94|uniprotkb:Q9MYB8|uniprotkb:Q9MYC3|uniprotkb:Q9MYC7|uniprotkb:Q9MYG1|uniprotkb:Q9TP35|uniprotkb:Q9UQS8|uniprotkb:Q9TP36|uniprotkb:Q9TP37|uniprotkb:Q9TP95|uniprotkb:Q9TPQ7|uniprotkb:Q9TPQ9|uniprotkb:Q9TPR2|uniprotkb:Q9TPR4|uniprotkb:Q9TPS6|uniprotkb:Q9TPT2|uniprotkb:Q9TPT4|uniprotkb:Q9TPT6|uniprotkb:Q9TPV2|uniprotkb:Q9TQG1|uniprotkb:Q9TQH3|uniprotkb:Q9TQH7|uniprotkb:Q9TQH8|uniprotkb:Q9TQH9|uniprotkb:Q9TQN4|uniprotkb:Q9TQN6	psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym)	psi-mi:hlab_human(display_long)|uniprotkb:Human leukocyte antigen B(gene name synonym)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:HLAB(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13918370|imex:IM-25681-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2	rcsb pdb:2HJL|rcsb pdb:2NW3|rcsb pdb:2A83|rcsb pdb:2NX5|rcsb pdb:2RFX|rcsb pdb:2YPK|rcsb pdb:2YPL|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BW9|rcsb pdb:3BWA|rcsb pdb:3C9N|rcsb pdb:3CZF|rcsb pdb:3D18|rcsb pdb:3DTX|rcsb pdb:2AK4|rcsb pdb:3DX6|rcsb pdb:3DX7|rcsb pdb:2AXF|rcsb pdb:3DX8|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:3HCV|rcsb pdb:2AXG|rcsb pdb:2BSR|rcsb pdb:2BSS|rcsb pdb:2BST|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:3KPL|rcsb pdb:3KPM|rcsb pdb:3KPN|rcsb pdb:3KPO|rcsb pdb:3KPP|rcsb pdb:3KPQ|rcsb pdb:3KPR|rcsb pdb:3KPS|rcsb pdb:3KWW|rcsb pdb:3KXF|rcsb pdb:3L3D|rcsb pdb:2H6P|rcsb pdb:3L3G|rcsb pdb:3L3I|rcsb pdb:3L3J|rcsb pdb:3L3K|rcsb pdb:3LN5|rcsb pdb:3LV3|rcsb pdb:3MV7|rcsb pdb:3LKN|rcsb pdb:3LKO|rcsb pdb:3LKP|rcsb pdb:3MV8|rcsb pdb:3MV9|rcsb pdb:3SJV|rcsb pdb:3SKM|rcsb pdb:3SKO|rcsb pdb:3SPV|rcsb pdb:3UPR|rcsb pdb:3VCL|rcsb pdb:3VFS|rcsb pdb:3VFT|rcsb pdb:3VFU|rcsb pdb:3VFV|rcsb pdb:3VFW|rcsb pdb:3VH8|rcsb pdb:3VRI|rcsb pdb:3LKQ|rcsb pdb:3LKR|rcsb pdb:3LKS|rcsb pdb:3LN4|rcsb pdb:3VRJ|rcsb pdb:3W39|rcsb pdb:3WUW|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:3X13|rcsb pdb:3X14|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|interpro:IPR037055|rcsb pdb:1A1M|rcsb pdb:1A1N|interpro:IPR036179|rcsb pdb:1A1O|rcsb pdb:1A9B|rcsb pdb:1A9E|rcsb pdb:1AGB|rcsb pdb:1AGC|rcsb pdb:1AGD|rcsb pdb:1AGE|rcsb pdb:1AGF|rcsb pdb:1CG9|rcsb pdb:1E27|rcsb pdb:1E28|rcsb pdb:1HSA|rcsb pdb:1JGD|rcsb pdb:1JGE|rcsb pdb:1K5N|rcsb pdb:1M05|rcsb pdb:1M6O|rcsb pdb:1MI5|rcsb pdb:1N2R|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:1SYS|rcsb pdb:1SYV|rcsb pdb:1UXS|rcsb pdb:1UXW|rcsb pdb:1W0V|rcsb pdb:1W0W|rcsb pdb:1XH3|rcsb pdb:1XR8|rcsb pdb:1XR9|rcsb pdb:1ZHK|rcsb pdb:1ZHL|rcsb pdb:1ZSD|rcsb pdb:4JQV|rcsb pdb:4JQX|rcsb pdb:4LCY|rcsb pdb:4LNR|rcsb pdb:4MJI|rcsb pdb:4G9F|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PR5|rcsb pdb:4PRN|rcsb pdb:4QRP|rcsb pdb:4QRQ|rcsb pdb:4QRR|rcsb pdb:4QRS|rcsb pdb:4QRT|rcsb pdb:4QRU|rcsb pdb:4U1H|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1K|rcsb pdb:4U1L|rcsb pdb:4U1M|rcsb pdb:4U1N|rcsb pdb:4U1S|rcsb pdb:4XXC|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5EO0|rcsb pdb:5EO1|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5TXS|rcsb pdb:5U98|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:5IEH|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5IEK|rcsb pdb:5VUF|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5VWH|rcsb pdb:5VWJ|rcsb pdb:5VZ5|rcsb pdb:5WMN|rcsb pdb:5WMO|rcsb pdb:5WMP|rcsb pdb:5IM7|rcsb pdb:5WMQ|rcsb pdb:5WMR|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5INC|rcsb pdb:6AT5|rcsb pdb:6AVF|rcsb pdb:5IND|rcsb pdb:5T6W|rcsb pdb:6AVG|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6BJ8|rcsb pdb:6BXP|rcsb pdb:5T6X|rcsb pdb:6BXQ|rcsb pdb:5T6Y|rcsb pdb:6D29|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T|rcsb pdb:6MT3|rcsb pdb:6MT4|rcsb pdb:6MT5|rcsb pdb:6MT6|ensembl:ENSG00000234745(gene)|ensembl:ENST00000412585(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:6MTM|rcsb pdb:6P23|rcsb pdb:6P27|rcsb pdb:6P2C|rcsb pdb:6P2F|rcsb pdb:6P2S|rcsb pdb:6PYJ|rcsb pdb:6PYL|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6VMX|rcsb pdb:7LFZ|rcsb pdb:7LG0|rcsb pdb:7LGD|rcsb pdb:7LGT|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6MTL|refseq:NP_005505.2	-	comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis"	-	figure legend:Fig 1,  Supp Fig 3-15|comment:B7301  allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606	rogid:NlO2PZ/66RypUzj8Euht3hRq8H89606	rigid:EigCpigW/qhzOcUXWdti9/gMzy0	false	fc-igg tag:?-?|mutation decreasing interaction strength:92-92	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P43628	uniprotkb:P01889	intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472	intact:EBI-1046513|ensembl:ENSP00000399168|uniprotkb:O62901|uniprotkb:O95730|uniprotkb:O98140|uniprotkb:P79542|uniprotkb:Q95369|uniprotkb:Q95J00|uniprotkb:Q9GJ20|uniprotkb:Q9MY78|uniprotkb:Q9MYF4|uniprotkb:Q9TQH6|uniprotkb:Q9TQM2|uniprotkb:Q9UQT0|intact:EBI-1049793|intact:EBI-6163549|intact:EBI-6163552|intact:EBI-6163582|intact:EBI-6163570|intact:EBI-6163579|intact:EBI-6163555|intact:EBI-9978548|intact:EBI-1047909|intact:EBI-8770324|uniprotkb:A0A2I6Q7B5|uniprotkb:B0V0B8|uniprotkb:G3GN01|uniprotkb:O02862|uniprotkb:O02956|uniprotkb:O02957|uniprotkb:O02960|uniprotkb:O19555|uniprotkb:O19556|uniprotkb:O19595|uniprotkb:O19615|uniprotkb:O19624|uniprotkb:O78163|uniprotkb:O78172|intact:EBI-1054175|uniprotkb:O19625|uniprotkb:O19627|uniprotkb:O19641|uniprotkb:O19651|uniprotkb:O19675|uniprotkb:O19692|uniprotkb:O19758|uniprotkb:O19779|uniprotkb:O19783|uniprotkb:O46702|uniprotkb:O62897|uniprotkb:O62915|uniprotkb:O62917|uniprotkb:O62919|uniprotkb:O77933|uniprotkb:O77959|uniprotkb:O78053|uniprotkb:O78138|uniprotkb:O78160|uniprotkb:O78173|uniprotkb:O78180|uniprotkb:O78217|uniprotkb:P01890|uniprotkb:P03989|uniprotkb:P10317|uniprotkb:P10318|uniprotkb:P10319|uniprotkb:P10320|uniprotkb:P18463|uniprotkb:P18464|uniprotkb:P18465|uniprotkb:P19373|uniprotkb:P30460|uniprotkb:P30461|uniprotkb:P30462|uniprotkb:P30463|uniprotkb:P30464|uniprotkb:P30465|uniprotkb:P30466|uniprotkb:P30467|uniprotkb:P30468|uniprotkb:P30469|uniprotkb:P30470|uniprotkb:P30471|uniprotkb:P30472|uniprotkb:P30473|uniprotkb:P30474|uniprotkb:P30475|uniprotkb:P30476|uniprotkb:P30477|uniprotkb:P30478|uniprotkb:P30479|uniprotkb:P30480|uniprotkb:P30481|uniprotkb:Q29693|uniprotkb:Q29695|uniprotkb:Q29697|uniprotkb:Q29718|uniprotkb:Q29742|uniprotkb:Q29749|uniprotkb:Q29762|uniprotkb:Q29764|uniprotkb:Q29829|uniprotkb:Q29836|uniprotkb:Q29842|uniprotkb:Q29845|uniprotkb:Q29846|uniprotkb:Q29847|uniprotkb:Q29848|uniprotkb:Q29850|uniprotkb:Q29851|uniprotkb:Q29852|uniprotkb:P30482|uniprotkb:P30483|uniprotkb:P30484|uniprotkb:P30485|uniprotkb:P30486|uniprotkb:P30487|uniprotkb:P30488|uniprotkb:P30489|uniprotkb:P30490|uniprotkb:P30491|uniprotkb:P30492|uniprotkb:P30493|uniprotkb:P30494|uniprotkb:P30495|uniprotkb:P30496|uniprotkb:P30497|uniprotkb:P30498|uniprotkb:P30513|uniprotkb:P30685|uniprotkb:P79489|uniprotkb:P79490|uniprotkb:P79496|uniprotkb:P79504|uniprotkb:P79523|uniprotkb:P79524|uniprotkb:P79555|uniprotkb:Q04826|uniprotkb:Q08136|uniprotkb:Q29633|uniprotkb:Q29636|uniprotkb:Q29638|uniprotkb:Q29661|uniprotkb:Q29665|uniprotkb:Q29678|uniprotkb:Q29679|uniprotkb:Q29681|uniprotkb:Q29935|uniprotkb:Q29936|uniprotkb:Q29940|uniprotkb:Q29953|uniprotkb:Q29961|uniprotkb:Q29982|intact:EBI-4289931|intact:EBI-7382650|intact:MINT-144207|intact:EBI-7245379|intact:MINT-1195012|intact:EBI-1059117|intact:EBI-4289845|uniprotkb:Q29854|uniprotkb:Q29855|uniprotkb:Q29857|uniprotkb:Q29858|uniprotkb:Q29861|uniprotkb:Q29924|uniprotkb:Q29925|uniprotkb:Q29933|uniprotkb:Q8MHN4|uniprotkb:Q30173|uniprotkb:Q30198|uniprotkb:Q31603|uniprotkb:Q31610|uniprotkb:Q31612|uniprotkb:Q31613|uniprotkb:Q546L8|uniprotkb:Q546M4|uniprotkb:Q5JP37|uniprotkb:Q5QT24|uniprotkb:Q5RIP1|uniprotkb:Q5SRJ2|uniprotkb:Q5TK76|uniprotkb:Q5TK77|uniprotkb:Q860I4|uniprotkb:Q861B5|uniprotkb:Q8HWF0|uniprotkb:Q8MGQ3|uniprotkb:Q8SNC5|uniprotkb:Q95343|uniprotkb:Q95344|uniprotkb:Q95365|uniprotkb:Q95392|uniprotkb:Q95HA3|uniprotkb:Q95HA8|uniprotkb:Q95HM9|uniprotkb:Q95IA6|uniprotkb:Q95IB8|uniprotkb:Q95IH5|uniprotkb:Q96IT9|uniprotkb:Q9BCM6|uniprotkb:Q9BCM7|uniprotkb:Q9BCM8|uniprotkb:Q9BD06|uniprotkb:Q9BD38|uniprotkb:Q9BD43|uniprotkb:Q9GIL3|uniprotkb:Q9GIM3|uniprotkb:Q9GIX1|uniprotkb:Q9GIY5|uniprotkb:Q9GIZ0|uniprotkb:Q9GIZ9|uniprotkb:Q9GJ00|uniprotkb:Q9GJ17|uniprotkb:Q9GJ23|uniprotkb:Q9GJ31|uniprotkb:Q9GJF0|uniprotkb:Q9GJM7|uniprotkb:Q9MX21|uniprotkb:Q9MY37|uniprotkb:Q9MY42|uniprotkb:Q9MY43|uniprotkb:Q9MY61|uniprotkb:Q9MY75|uniprotkb:Q9MY79|uniprotkb:Q9MY84|uniprotkb:Q9MY92|uniprotkb:Q9MY93|uniprotkb:Q9MY94|uniprotkb:Q9MYB8|uniprotkb:Q9MYC3|uniprotkb:Q9MYC7|uniprotkb:Q9MYG1|uniprotkb:Q9TP35|uniprotkb:Q9UQS8|uniprotkb:Q9TP36|uniprotkb:Q9TP37|uniprotkb:Q9TP95|uniprotkb:Q9TPQ7|uniprotkb:Q9TPQ9|uniprotkb:Q9TPR2|uniprotkb:Q9TPR4|uniprotkb:Q9TPS6|uniprotkb:Q9TPT2|uniprotkb:Q9TPT4|uniprotkb:Q9TPT6|uniprotkb:Q9TPV2|uniprotkb:Q9TQG1|uniprotkb:Q9TQH3|uniprotkb:Q9TQH7|uniprotkb:Q9TQH8|uniprotkb:Q9TQH9|uniprotkb:Q9TQN4|uniprotkb:Q9TQN6	psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym)	psi-mi:hlab_human(display_long)|uniprotkb:Human leukocyte antigen B(gene name synonym)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:HLAB(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13918390|imex:IM-25681-36	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2	rcsb pdb:2HJL|rcsb pdb:2NW3|rcsb pdb:2A83|rcsb pdb:2NX5|rcsb pdb:2RFX|rcsb pdb:2YPK|rcsb pdb:2YPL|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BW9|rcsb pdb:3BWA|rcsb pdb:3C9N|rcsb pdb:3CZF|rcsb pdb:3D18|rcsb pdb:3DTX|rcsb pdb:2AK4|rcsb pdb:3DX6|rcsb pdb:3DX7|rcsb pdb:2AXF|rcsb pdb:3DX8|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:3HCV|rcsb pdb:2AXG|rcsb pdb:2BSR|rcsb pdb:2BSS|rcsb pdb:2BST|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:3KPL|rcsb pdb:3KPM|rcsb pdb:3KPN|rcsb pdb:3KPO|rcsb pdb:3KPP|rcsb pdb:3KPQ|rcsb pdb:3KPR|rcsb pdb:3KPS|rcsb pdb:3KWW|rcsb pdb:3KXF|rcsb pdb:3L3D|rcsb pdb:2H6P|rcsb pdb:3L3G|rcsb pdb:3L3I|rcsb pdb:3L3J|rcsb pdb:3L3K|rcsb pdb:3LN5|rcsb pdb:3LV3|rcsb pdb:3MV7|rcsb pdb:3LKN|rcsb pdb:3LKO|rcsb pdb:3LKP|rcsb pdb:3MV8|rcsb pdb:3MV9|rcsb pdb:3SJV|rcsb pdb:3SKM|rcsb pdb:3SKO|rcsb pdb:3SPV|rcsb pdb:3UPR|rcsb pdb:3VCL|rcsb pdb:3VFS|rcsb pdb:3VFT|rcsb pdb:3VFU|rcsb pdb:3VFV|rcsb pdb:3VFW|rcsb pdb:3VH8|rcsb pdb:3VRI|rcsb pdb:3LKQ|rcsb pdb:3LKR|rcsb pdb:3LKS|rcsb pdb:3LN4|rcsb pdb:3VRJ|rcsb pdb:3W39|rcsb pdb:3WUW|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:3X13|rcsb pdb:3X14|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|interpro:IPR037055|rcsb pdb:1A1M|rcsb pdb:1A1N|interpro:IPR036179|rcsb pdb:1A1O|rcsb pdb:1A9B|rcsb pdb:1A9E|rcsb pdb:1AGB|rcsb pdb:1AGC|rcsb pdb:1AGD|rcsb pdb:1AGE|rcsb pdb:1AGF|rcsb pdb:1CG9|rcsb pdb:1E27|rcsb pdb:1E28|rcsb pdb:1HSA|rcsb pdb:1JGD|rcsb pdb:1JGE|rcsb pdb:1K5N|rcsb pdb:1M05|rcsb pdb:1M6O|rcsb pdb:1MI5|rcsb pdb:1N2R|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:1SYS|rcsb pdb:1SYV|rcsb pdb:1UXS|rcsb pdb:1UXW|rcsb pdb:1W0V|rcsb pdb:1W0W|rcsb pdb:1XH3|rcsb pdb:1XR8|rcsb pdb:1XR9|rcsb pdb:1ZHK|rcsb pdb:1ZHL|rcsb pdb:1ZSD|rcsb pdb:4JQV|rcsb pdb:4JQX|rcsb pdb:4LCY|rcsb pdb:4LNR|rcsb pdb:4MJI|rcsb pdb:4G9F|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PR5|rcsb pdb:4PRN|rcsb pdb:4QRP|rcsb pdb:4QRQ|rcsb pdb:4QRR|rcsb pdb:4QRS|rcsb pdb:4QRT|rcsb pdb:4QRU|rcsb pdb:4U1H|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1K|rcsb pdb:4U1L|rcsb pdb:4U1M|rcsb pdb:4U1N|rcsb pdb:4U1S|rcsb pdb:4XXC|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5EO0|rcsb pdb:5EO1|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5TXS|rcsb pdb:5U98|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:5IEH|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5IEK|rcsb pdb:5VUF|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5VWH|rcsb pdb:5VWJ|rcsb pdb:5VZ5|rcsb pdb:5WMN|rcsb pdb:5WMO|rcsb pdb:5WMP|rcsb pdb:5IM7|rcsb pdb:5WMQ|rcsb pdb:5WMR|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5INC|rcsb pdb:6AT5|rcsb pdb:6AVF|rcsb pdb:5IND|rcsb pdb:5T6W|rcsb pdb:6AVG|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6BJ8|rcsb pdb:6BXP|rcsb pdb:5T6X|rcsb pdb:6BXQ|rcsb pdb:5T6Y|rcsb pdb:6D29|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T|rcsb pdb:6MT3|rcsb pdb:6MT4|rcsb pdb:6MT5|rcsb pdb:6MT6|ensembl:ENSG00000234745(gene)|ensembl:ENST00000412585(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:6MTM|rcsb pdb:6P23|rcsb pdb:6P27|rcsb pdb:6P2C|rcsb pdb:6P2F|rcsb pdb:6P2S|rcsb pdb:6PYJ|rcsb pdb:6PYL|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6VMX|rcsb pdb:7LFZ|rcsb pdb:7LG0|rcsb pdb:7LGD|rcsb pdb:7LGT|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6MTL|refseq:NP_005505.2	-	comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis"	-	figure legend:Fig 1,  Supp Fig 3-16|comment:B4601  allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2019/10/18	rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606	rogid:NlO2PZ/66RypUzj8Euht3hRq8H89606	rigid:EigCpigW/qhzOcUXWdti9/gMzy0	false	fc-igg tag:?-?|mutation decreasing interaction strength:92-92	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P43628	uniprotkb:Q5S3G3	intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472	intact:EBI-4290427|uniprotkb:Q9BCN0|uniprotkb:Q9MYI5|uniprotkb:Q9TQE9|uniprotkb:Q9TQP6|uniprotkb:Q9TQP7|uniprotkb:Q5S3G1	psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym)	psi-mi:q5s3g3_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:HLAA(gene name synonym)|uniprotkb:MHC class I antigen A*11(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Graef et al. (2009)	pubmed:19858347|imex:IM-25681	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13918400|imex:IM-25681-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2	uniprotkb:P13746(see-also)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019882"(antigen processing and presentation)|interpro:IPR036179|interpro:IPR037055|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)	-	comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis"	-	figure legend:Fig 1,  Supp Fig 3-17|comment:A1101 and A1102 alleles|comment:"Text states:- \"Mutating Gln71 to Pro71 in 2DL3 causes a gain of A*11 reactivity\" -in both 01 and 02 alleles."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/16	2017/02/22	rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606	rogid:zfvnDhAh7D90kAQGAuK6Ut2tWOA9606	rigid:6DMkgiUoB/PcS18FcU2MGLzs3aI	false	fc-igg tag:?-?|mutation:92-92	variant:43-43	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)