#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P28300	uniprotkb:O95967	intact:EBI-3893481|uniprotkb:B2R5Q3|uniprotkb:Q5FWF0|ensembl:ENSP00000231004	intact:EBI-743414|uniprotkb:O75967|uniprotkb:A8K7R4|uniprotkb:B3KM31|uniprotkb:B3KQT1|ensembl:ENSP00000309953|ensembl:ENSP00000435295	psi-mi:lyox_human(display_long)|uniprotkb:LOX(gene name)|psi-mi:LOX(display_short)|uniprotkb:Lysyl oxidase(gene name synonym)	psi-mi:fbln4_human(display_long)|uniprotkb:Fibulin-4(gene name synonym)|uniprotkb:Protein UPH1(gene name synonym)|uniprotkb:EFEMP2(gene name)|psi-mi:EFEMP2(display_short)|uniprotkb:FBLN4(gene name synonym)|uniprotkb:UNQ200/PRO226(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Horiguchi et al. (2009)	pubmed:19855011|doi:10.1073/pnas.0908268106|imex:IM-14865	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15811648|imex:IM-14865-1|dip:DIP-104186E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002308.2|dip:DIP-49007N|ensembl:ENSG00000113083(gene)|ensembl:ENST00000231004(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR019828|mint:P28300|reactome:R-HSA-1566948|reactome:R-HSA-2243919|go:"GO:0046716"(muscle cell cellular homeostasis)	refseq:NP_058634.4|ensembl:ENSG00000172638(gene)|ensembl:ENST00000307998(transcript)|ensembl:ENST00000531972(transcript)|go:"GO:0001527"(microfibril)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0008201"(heparin binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035904"(aorta development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071953"(elastic fiber)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904026"(regulation of collagen fibril organization)|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904831"(positive regulation of aortic smooth muscle cell differentiation)|go:"GO:1905609"(positive regulation of smooth muscle cell-matrix adhesion)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR026824|mint:O95967|rcsb pdb:2KL7|reactome:R-HSA-2129379|dip:DIP-34518N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2018/08/28	rogid:bDUlKQ5akDOhya4GydJ+PaLs7Fo9606	rogid:L8jMp8rFYb6DRRusfWgyd9zN2KI9606	rigid:HYX+WsbX/vAhuLn3EUoudnm9w3Y	false	myc tag:n-n	flag tag:n-n|sufficient binding region:26-122	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P28300	uniprotkb:O95967	intact:EBI-3893481|uniprotkb:B2R5Q3|uniprotkb:Q5FWF0|ensembl:ENSP00000231004	intact:EBI-743414|uniprotkb:O75967|uniprotkb:A8K7R4|uniprotkb:B3KM31|uniprotkb:B3KQT1|ensembl:ENSP00000309953|ensembl:ENSP00000435295	psi-mi:lyox_human(display_long)|uniprotkb:LOX(gene name)|psi-mi:LOX(display_short)|uniprotkb:Lysyl oxidase(gene name synonym)	psi-mi:fbln4_human(display_long)|uniprotkb:Fibulin-4(gene name synonym)|uniprotkb:Protein UPH1(gene name synonym)|uniprotkb:EFEMP2(gene name)|psi-mi:EFEMP2(display_short)|uniprotkb:FBLN4(gene name synonym)|uniprotkb:UNQ200/PRO226(orf name)	psi-mi:"MI:0892"(solid phase assay)	Horiguchi et al. (2009)	pubmed:19855011|doi:10.1073/pnas.0908268106|imex:IM-14865	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15811671|imex:IM-14865-2|dip:DIP-104186E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002308.2|dip:DIP-49007N|ensembl:ENSG00000113083(gene)|ensembl:ENST00000231004(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR019828|mint:P28300|reactome:R-HSA-1566948|reactome:R-HSA-2243919|go:"GO:0046716"(muscle cell cellular homeostasis)	refseq:NP_058634.4|ensembl:ENSG00000172638(gene)|ensembl:ENST00000307998(transcript)|ensembl:ENST00000531972(transcript)|go:"GO:0001527"(microfibril)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0008201"(heparin binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035904"(aorta development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071953"(elastic fiber)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904026"(regulation of collagen fibril organization)|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904831"(positive regulation of aortic smooth muscle cell differentiation)|go:"GO:1905609"(positive regulation of smooth muscle cell-matrix adhesion)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR026824|mint:O95967|rcsb pdb:2KL7|reactome:R-HSA-2129379|dip:DIP-34518N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2018/08/28	rogid:bDUlKQ5akDOhya4GydJ+PaLs7Fo9606	rogid:L8jMp8rFYb6DRRusfWgyd9zN2KI9606	rigid:HYX+WsbX/vAhuLn3EUoudnm9w3Y	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28300	uniprotkb:O95967	intact:EBI-3893481|uniprotkb:B2R5Q3|uniprotkb:Q5FWF0|ensembl:ENSP00000231004	intact:EBI-743414|uniprotkb:O75967|uniprotkb:A8K7R4|uniprotkb:B3KM31|uniprotkb:B3KQT1|ensembl:ENSP00000309953|ensembl:ENSP00000435295	psi-mi:lyox_human(display_long)|uniprotkb:LOX(gene name)|psi-mi:LOX(display_short)|uniprotkb:Lysyl oxidase(gene name synonym)	psi-mi:fbln4_human(display_long)|uniprotkb:Fibulin-4(gene name synonym)|uniprotkb:Protein UPH1(gene name synonym)|uniprotkb:EFEMP2(gene name)|psi-mi:EFEMP2(display_short)|uniprotkb:FBLN4(gene name synonym)|uniprotkb:UNQ200/PRO226(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Horiguchi et al. (2009)	pubmed:19855011|doi:10.1073/pnas.0908268106|imex:IM-14865	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15811688|imex:IM-14865-3|dip:DIP-104186E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002308.2|dip:DIP-49007N|ensembl:ENSG00000113083(gene)|ensembl:ENST00000231004(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR019828|mint:P28300|reactome:R-HSA-1566948|reactome:R-HSA-2243919|go:"GO:0046716"(muscle cell cellular homeostasis)	refseq:NP_058634.4|ensembl:ENSG00000172638(gene)|ensembl:ENST00000307998(transcript)|ensembl:ENST00000531972(transcript)|go:"GO:0001527"(microfibril)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0008201"(heparin binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035904"(aorta development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071953"(elastic fiber)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904026"(regulation of collagen fibril organization)|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904831"(positive regulation of aortic smooth muscle cell differentiation)|go:"GO:1905609"(positive regulation of smooth muscle cell-matrix adhesion)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR026824|mint:O95967|rcsb pdb:2KL7|reactome:R-HSA-2129379|dip:DIP-34518N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2018/08/28	rogid:bDUlKQ5akDOhya4GydJ+PaLs7Fo9606	rogid:L8jMp8rFYb6DRRusfWgyd9zN2KI9606	rigid:HYX+WsbX/vAhuLn3EUoudnm9w3Y	false	flag tag:n-n|sufficient binding region:22-168	myc tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)