#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O14746	uniprotkb:P03126	intact:EBI-1772203|uniprotkb:O14783|uniprotkb:Q2XS35|uniprotkb:Q8N6C3|uniprotkb:Q8NG46|uniprotkb:Q8NG38|ensembl:ENSP00000309572	intact:EBI-1177242|uniprotkb:Q71BI7	psi-mi:tert_human(display_long)|uniprotkb:TERT(gene name)|psi-mi:TERT(display_short)|uniprotkb:EST2(gene name synonym)|uniprotkb:TCS1(gene name synonym)|uniprotkb:TRT(gene name synonym)|uniprotkb:Telomerase catalytic subunit(gene name synonym)|uniprotkb:HEST2(gene name synonym)|uniprotkb:Telomerase-associated protein 2(gene name synonym)	psi-mi:ve6_hpv16(display_long)|uniprotkb:E6(gene name)|psi-mi:E6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Liu et al. (2009)	pubmed:19843693|doi:10.1073/pnas.0906357106|imex:IM-14863	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15811295|imex:IM-14863-3|dip:DIP-104184E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001180305.1|refseq:NP_937983.2|dip:DIP-40646N|ensembl:ENSG00000164362(gene)|ensembl:ENST00000310581(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000333"(telomerase catalytic core complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0003721"(telomerase RNA reverse transcriptase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0022616"(DNA strand elongation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031379"(RNA-directed RNA polymerase complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042635"(positive regulation of hair cycle)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0062103"(double-stranded RNA biosynthetic process)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0090399"(replicative senescence)|go:"GO:0098680"(template-free RNA nucleotidyltransferase)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903620"(positive regulation of transdifferentiation)|go:"GO:1903704"(negative regulation of production of siRNA involved in RNA interference)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990572"(TERT-RMRP complex)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR003545(Telomere reverse transcriptase)|interpro:IPR021891|interpro:IPR043502|mint:O14746|rcsb pdb:2BCK|rcsb pdb:4B18|rcsb pdb:4MNQ|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MER|rcsb pdb:5UGW|rcsb pdb:7BG9|reactome:R-HSA-171319|reactome:R-HSA-201722|rcsb pdb:5MEQ	refseq:NP_041325.1|go:"GO:0003677"(DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR001334(E6 early regulatory protein)|interpro:IPR038575|rcsb pdb:1VZN|rcsb pdb:2FK4|rcsb pdb:2KPL|rcsb pdb:2LJX|rcsb pdb:2LJY|rcsb pdb:2LJZ|rcsb pdb:4GIZ|rcsb pdb:4JOP|rcsb pdb:4XR8|rcsb pdb:6HKS|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|mint:P03126|dip:DIP-44706N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/06	2017/08/10	rogid:jHm8Li7IWhFinYJ5gmXQJypHdUc9606	rogid:m9USUwG2VskhrMAdtZ9gSULmGBY333760	rigid:0R9jhkMe7bP9VAx/DolOc7RDOJw	false	-	green fluorescent protein tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14746	uniprotkb:P03126	intact:EBI-1772203|uniprotkb:O14783|uniprotkb:Q2XS35|uniprotkb:Q8N6C3|uniprotkb:Q8NG46|uniprotkb:Q8NG38|ensembl:ENSP00000309572	intact:EBI-1177242|uniprotkb:Q71BI7	psi-mi:tert_human(display_long)|uniprotkb:TERT(gene name)|psi-mi:TERT(display_short)|uniprotkb:EST2(gene name synonym)|uniprotkb:TCS1(gene name synonym)|uniprotkb:TRT(gene name synonym)|uniprotkb:Telomerase catalytic subunit(gene name synonym)|uniprotkb:HEST2(gene name synonym)|uniprotkb:Telomerase-associated protein 2(gene name synonym)	psi-mi:ve6_hpv16(display_long)|uniprotkb:E6(gene name)|psi-mi:E6(display_short)	psi-mi:"MI:0096"(pull down)	Liu et al. (2009)	pubmed:19843693|doi:10.1073/pnas.0906357106|imex:IM-14863	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15811274|imex:IM-14863-2|dip:DIP-104184E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001180305.1|refseq:NP_937983.2|dip:DIP-40646N|ensembl:ENSG00000164362(gene)|ensembl:ENST00000310581(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000333"(telomerase catalytic core complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0003721"(telomerase RNA reverse transcriptase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0022616"(DNA strand elongation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031379"(RNA-directed RNA polymerase complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042635"(positive regulation of hair cycle)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0062103"(double-stranded RNA biosynthetic process)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0090399"(replicative senescence)|go:"GO:0098680"(template-free RNA nucleotidyltransferase)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903620"(positive regulation of transdifferentiation)|go:"GO:1903704"(negative regulation of production of siRNA involved in RNA interference)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990572"(TERT-RMRP complex)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR003545(Telomere reverse transcriptase)|interpro:IPR021891|interpro:IPR043502|mint:O14746|rcsb pdb:2BCK|rcsb pdb:4B18|rcsb pdb:4MNQ|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MER|rcsb pdb:5UGW|rcsb pdb:7BG9|reactome:R-HSA-171319|reactome:R-HSA-201722|rcsb pdb:5MEQ	refseq:NP_041325.1|go:"GO:0003677"(DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR001334(E6 early regulatory protein)|interpro:IPR038575|rcsb pdb:1VZN|rcsb pdb:2FK4|rcsb pdb:2KPL|rcsb pdb:2LJX|rcsb pdb:2LJY|rcsb pdb:2LJZ|rcsb pdb:4GIZ|rcsb pdb:4JOP|rcsb pdb:4XR8|rcsb pdb:6HKS|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|mint:P03126|dip:DIP-44706N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:jHm8Li7IWhFinYJ5gmXQJypHdUc9606	rogid:m9USUwG2VskhrMAdtZ9gSULmGBY333760	rigid:0R9jhkMe7bP9VAx/DolOc7RDOJw	false	ha tag:c-c	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O14746	uniprotkb:P03126	intact:EBI-1772203|uniprotkb:O14783|uniprotkb:Q2XS35|uniprotkb:Q8N6C3|uniprotkb:Q8NG46|uniprotkb:Q8NG38|ensembl:ENSP00000309572	intact:EBI-1177242|uniprotkb:Q71BI7	psi-mi:tert_human(display_long)|uniprotkb:TERT(gene name)|psi-mi:TERT(display_short)|uniprotkb:EST2(gene name synonym)|uniprotkb:TCS1(gene name synonym)|uniprotkb:TRT(gene name synonym)|uniprotkb:Telomerase catalytic subunit(gene name synonym)|uniprotkb:HEST2(gene name synonym)|uniprotkb:Telomerase-associated protein 2(gene name synonym)	psi-mi:ve6_hpv16(display_long)|uniprotkb:E6(gene name)|psi-mi:E6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Liu et al. (2009)	pubmed:19843693|doi:10.1073/pnas.0906357106|imex:IM-14863	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15811255|imex:IM-14863-1|dip:DIP-104184E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001180305.1|refseq:NP_937983.2|dip:DIP-40646N|ensembl:ENSG00000164362(gene)|ensembl:ENST00000310581(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000333"(telomerase catalytic core complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0003721"(telomerase RNA reverse transcriptase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0022616"(DNA strand elongation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031379"(RNA-directed RNA polymerase complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042635"(positive regulation of hair cycle)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0062103"(double-stranded RNA biosynthetic process)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0090399"(replicative senescence)|go:"GO:0098680"(template-free RNA nucleotidyltransferase)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903620"(positive regulation of transdifferentiation)|go:"GO:1903704"(negative regulation of production of siRNA involved in RNA interference)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990572"(TERT-RMRP complex)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR003545(Telomere reverse transcriptase)|interpro:IPR021891|interpro:IPR043502|mint:O14746|rcsb pdb:2BCK|rcsb pdb:4B18|rcsb pdb:4MNQ|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MER|rcsb pdb:5UGW|rcsb pdb:7BG9|reactome:R-HSA-171319|reactome:R-HSA-201722|rcsb pdb:5MEQ	refseq:NP_041325.1|go:"GO:0003677"(DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR001334(E6 early regulatory protein)|interpro:IPR038575|rcsb pdb:1VZN|rcsb pdb:2FK4|rcsb pdb:2KPL|rcsb pdb:2LJX|rcsb pdb:2LJY|rcsb pdb:2LJZ|rcsb pdb:4GIZ|rcsb pdb:4JOP|rcsb pdb:4XR8|rcsb pdb:6HKS|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|mint:P03126|dip:DIP-44706N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/06	2017/08/10	rogid:jHm8Li7IWhFinYJ5gmXQJypHdUc9606	rogid:m9USUwG2VskhrMAdtZ9gSULmGBY333760	rigid:0R9jhkMe7bP9VAx/DolOc7RDOJw	false	-	au1 tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14746	uniprotkb:P03126	intact:EBI-1772203|uniprotkb:O14783|uniprotkb:Q2XS35|uniprotkb:Q8N6C3|uniprotkb:Q8NG46|uniprotkb:Q8NG38|ensembl:ENSP00000309572	intact:EBI-1177242|uniprotkb:Q71BI7	psi-mi:tert_human(display_long)|uniprotkb:TERT(gene name)|psi-mi:TERT(display_short)|uniprotkb:EST2(gene name synonym)|uniprotkb:TCS1(gene name synonym)|uniprotkb:TRT(gene name synonym)|uniprotkb:Telomerase catalytic subunit(gene name synonym)|uniprotkb:HEST2(gene name synonym)|uniprotkb:Telomerase-associated protein 2(gene name synonym)	psi-mi:ve6_hpv16(display_long)|uniprotkb:E6(gene name)|psi-mi:E6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Liu et al. (2009)	pubmed:19843693|doi:10.1073/pnas.0906357106|imex:IM-14863	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15811352|imex:IM-14863-6|dip:DIP-104184E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001180305.1|refseq:NP_937983.2|dip:DIP-40646N|ensembl:ENSG00000164362(gene)|ensembl:ENST00000310581(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000333"(telomerase catalytic core complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0003721"(telomerase RNA reverse transcriptase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0022616"(DNA strand elongation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031379"(RNA-directed RNA polymerase complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042635"(positive regulation of hair cycle)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0062103"(double-stranded RNA biosynthetic process)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0090399"(replicative senescence)|go:"GO:0098680"(template-free RNA nucleotidyltransferase)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903620"(positive regulation of transdifferentiation)|go:"GO:1903704"(negative regulation of production of siRNA involved in RNA interference)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990572"(TERT-RMRP complex)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR003545(Telomere reverse transcriptase)|interpro:IPR021891|interpro:IPR043502|mint:O14746|rcsb pdb:2BCK|rcsb pdb:4B18|rcsb pdb:4MNQ|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MER|rcsb pdb:5UGW|rcsb pdb:7BG9|reactome:R-HSA-171319|reactome:R-HSA-201722|rcsb pdb:5MEQ	refseq:NP_041325.1|go:"GO:0003677"(DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR001334(E6 early regulatory protein)|interpro:IPR038575|rcsb pdb:1VZN|rcsb pdb:2FK4|rcsb pdb:2KPL|rcsb pdb:2LJX|rcsb pdb:2LJY|rcsb pdb:2LJZ|rcsb pdb:4GIZ|rcsb pdb:4JOP|rcsb pdb:4XR8|rcsb pdb:6HKS|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|mint:P03126|dip:DIP-44706N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/06	2017/08/10	rogid:jHm8Li7IWhFinYJ5gmXQJypHdUc9606	rogid:m9USUwG2VskhrMAdtZ9gSULmGBY333760	rigid:0R9jhkMe7bP9VAx/DolOc7RDOJw	false	-	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14746	uniprotkb:P03126	intact:EBI-1772203|uniprotkb:O14783|uniprotkb:Q2XS35|uniprotkb:Q8N6C3|uniprotkb:Q8NG46|uniprotkb:Q8NG38|ensembl:ENSP00000309572	intact:EBI-1177242|uniprotkb:Q71BI7	psi-mi:tert_human(display_long)|uniprotkb:TERT(gene name)|psi-mi:TERT(display_short)|uniprotkb:EST2(gene name synonym)|uniprotkb:TCS1(gene name synonym)|uniprotkb:TRT(gene name synonym)|uniprotkb:Telomerase catalytic subunit(gene name synonym)|uniprotkb:HEST2(gene name synonym)|uniprotkb:Telomerase-associated protein 2(gene name synonym)	psi-mi:ve6_hpv16(display_long)|uniprotkb:E6(gene name)|psi-mi:E6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Liu et al. (2009)	pubmed:19843693|doi:10.1073/pnas.0906357106|imex:IM-14863	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15811333|imex:IM-14863-5|dip:DIP-104184E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001180305.1|refseq:NP_937983.2|dip:DIP-40646N|ensembl:ENSG00000164362(gene)|ensembl:ENST00000310581(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000333"(telomerase catalytic core complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0003721"(telomerase RNA reverse transcriptase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0022616"(DNA strand elongation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031379"(RNA-directed RNA polymerase complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042635"(positive regulation of hair cycle)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0062103"(double-stranded RNA biosynthetic process)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0090399"(replicative senescence)|go:"GO:0098680"(template-free RNA nucleotidyltransferase)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903620"(positive regulation of transdifferentiation)|go:"GO:1903704"(negative regulation of production of siRNA involved in RNA interference)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990572"(TERT-RMRP complex)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR003545(Telomere reverse transcriptase)|interpro:IPR021891|interpro:IPR043502|mint:O14746|rcsb pdb:2BCK|rcsb pdb:4B18|rcsb pdb:4MNQ|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MER|rcsb pdb:5UGW|rcsb pdb:7BG9|reactome:R-HSA-171319|reactome:R-HSA-201722|rcsb pdb:5MEQ	refseq:NP_041325.1|go:"GO:0003677"(DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR001334(E6 early regulatory protein)|interpro:IPR038575|rcsb pdb:1VZN|rcsb pdb:2FK4|rcsb pdb:2KPL|rcsb pdb:2LJX|rcsb pdb:2LJY|rcsb pdb:2LJZ|rcsb pdb:4GIZ|rcsb pdb:4JOP|rcsb pdb:4XR8|rcsb pdb:6HKS|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|mint:P03126|dip:DIP-44706N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/06	2017/08/10	rogid:jHm8Li7IWhFinYJ5gmXQJypHdUc9606	rogid:m9USUwG2VskhrMAdtZ9gSULmGBY333760	rigid:0R9jhkMe7bP9VAx/DolOc7RDOJw	false	-	au1 tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14746	uniprotkb:P03126	intact:EBI-1772203|uniprotkb:O14783|uniprotkb:Q2XS35|uniprotkb:Q8N6C3|uniprotkb:Q8NG46|uniprotkb:Q8NG38|ensembl:ENSP00000309572	intact:EBI-1177242|uniprotkb:Q71BI7	psi-mi:tert_human(display_long)|uniprotkb:TERT(gene name)|psi-mi:TERT(display_short)|uniprotkb:EST2(gene name synonym)|uniprotkb:TCS1(gene name synonym)|uniprotkb:TRT(gene name synonym)|uniprotkb:Telomerase catalytic subunit(gene name synonym)|uniprotkb:HEST2(gene name synonym)|uniprotkb:Telomerase-associated protein 2(gene name synonym)	psi-mi:ve6_hpv16(display_long)|uniprotkb:E6(gene name)|psi-mi:E6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Liu et al. (2009)	pubmed:19843693|doi:10.1073/pnas.0906357106|imex:IM-14863	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15811314|imex:IM-14863-4|dip:DIP-104184E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001180305.1|refseq:NP_937983.2|dip:DIP-40646N|ensembl:ENSG00000164362(gene)|ensembl:ENST00000310581(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000333"(telomerase catalytic core complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0003721"(telomerase RNA reverse transcriptase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0022616"(DNA strand elongation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031379"(RNA-directed RNA polymerase complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042635"(positive regulation of hair cycle)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0062103"(double-stranded RNA biosynthetic process)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0090399"(replicative senescence)|go:"GO:0098680"(template-free RNA nucleotidyltransferase)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903620"(positive regulation of transdifferentiation)|go:"GO:1903704"(negative regulation of production of siRNA involved in RNA interference)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990572"(TERT-RMRP complex)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR003545(Telomere reverse transcriptase)|interpro:IPR021891|interpro:IPR043502|mint:O14746|rcsb pdb:2BCK|rcsb pdb:4B18|rcsb pdb:4MNQ|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MER|rcsb pdb:5UGW|rcsb pdb:7BG9|reactome:R-HSA-171319|reactome:R-HSA-201722|rcsb pdb:5MEQ	refseq:NP_041325.1|go:"GO:0003677"(DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR001334(E6 early regulatory protein)|interpro:IPR038575|rcsb pdb:1VZN|rcsb pdb:2FK4|rcsb pdb:2KPL|rcsb pdb:2LJX|rcsb pdb:2LJY|rcsb pdb:2LJZ|rcsb pdb:4GIZ|rcsb pdb:4JOP|rcsb pdb:4XR8|rcsb pdb:6HKS|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|mint:P03126|dip:DIP-44706N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/06	2017/08/10	rogid:jHm8Li7IWhFinYJ5gmXQJypHdUc9606	rogid:m9USUwG2VskhrMAdtZ9gSULmGBY333760	rigid:0R9jhkMe7bP9VAx/DolOc7RDOJw	false	-	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14746	uniprotkb:P03126	intact:EBI-1772203|uniprotkb:O14783|uniprotkb:Q2XS35|uniprotkb:Q8N6C3|uniprotkb:Q8NG46|uniprotkb:Q8NG38|ensembl:ENSP00000309572	intact:EBI-1177242|uniprotkb:Q71BI7	psi-mi:tert_human(display_long)|uniprotkb:TERT(gene name)|psi-mi:TERT(display_short)|uniprotkb:EST2(gene name synonym)|uniprotkb:TCS1(gene name synonym)|uniprotkb:TRT(gene name synonym)|uniprotkb:Telomerase catalytic subunit(gene name synonym)|uniprotkb:HEST2(gene name synonym)|uniprotkb:Telomerase-associated protein 2(gene name synonym)	psi-mi:ve6_hpv16(display_long)|uniprotkb:E6(gene name)|psi-mi:E6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Liu et al. (2009)	pubmed:19843693|doi:10.1073/pnas.0906357106|imex:IM-14863	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15811371|imex:IM-14863-7|dip:DIP-104184E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001180305.1|refseq:NP_937983.2|dip:DIP-40646N|ensembl:ENSG00000164362(gene)|ensembl:ENST00000310581(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000333"(telomerase catalytic core complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0003721"(telomerase RNA reverse transcriptase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0022616"(DNA strand elongation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031379"(RNA-directed RNA polymerase complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042635"(positive regulation of hair cycle)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0062103"(double-stranded RNA biosynthetic process)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0090399"(replicative senescence)|go:"GO:0098680"(template-free RNA nucleotidyltransferase)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903620"(positive regulation of transdifferentiation)|go:"GO:1903704"(negative regulation of production of siRNA involved in RNA interference)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990572"(TERT-RMRP complex)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR003545(Telomere reverse transcriptase)|interpro:IPR021891|interpro:IPR043502|mint:O14746|rcsb pdb:2BCK|rcsb pdb:4B18|rcsb pdb:4MNQ|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MER|rcsb pdb:5UGW|rcsb pdb:7BG9|reactome:R-HSA-171319|reactome:R-HSA-201722|rcsb pdb:5MEQ	refseq:NP_041325.1|go:"GO:0003677"(DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR001334(E6 early regulatory protein)|interpro:IPR038575|rcsb pdb:1VZN|rcsb pdb:2FK4|rcsb pdb:2KPL|rcsb pdb:2LJX|rcsb pdb:2LJY|rcsb pdb:2LJZ|rcsb pdb:4GIZ|rcsb pdb:4JOP|rcsb pdb:4XR8|rcsb pdb:6HKS|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|mint:P03126|dip:DIP-44706N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/06	2017/08/10	rogid:jHm8Li7IWhFinYJ5gmXQJypHdUc9606	rogid:m9USUwG2VskhrMAdtZ9gSULmGBY333760	rigid:0R9jhkMe7bP9VAx/DolOc7RDOJw	false	-	green fluorescent protein tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)