#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P52799	uniprotkb:P54764	intact:EBI-7532268|intact:MINT-3019741|uniprotkb:Q5JV56|ensembl:ENSP00000493716	intact:EBI-5773557|uniprotkb:A8K2P1|uniprotkb:B2R601|uniprotkb:B7Z6Q8|uniprotkb:Q2M380|ensembl:ENSP00000281821|ensembl:ENSP00000386829	psi-mi:efnb2_human(display_long)|uniprotkb:EFNB2(gene name)|psi-mi:EFNB2(display_short)|uniprotkb:EPLG5(gene name synonym)|uniprotkb:HTKL(gene name synonym)|uniprotkb:LERK5(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 5(gene name synonym)|uniprotkb:HTK ligand(gene name synonym)	psi-mi:epha4_human(display_long)|uniprotkb:EPHA4(gene name)|psi-mi:EPHA4(display_short)|uniprotkb:EPH-like kinase 8(gene name synonym)|uniprotkb:HEK8(gene name synonym)|uniprotkb:SEK(gene name synonym)|uniprotkb:TYRO1(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor SEK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bowden et al. (2009)	pubmed:19836338|doi:10.1016/j.str.2009.07.018|imex:IM-11744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15810241|imex:IM-11744-1|dip:DIP-102507E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004084.1|ensembl:ENSG00000125266(gene)|ensembl:ENST00000646441(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|interpro:IPR034255|mint:P52799|rcsb pdb:2HLE|rcsb pdb:2I85|rcsb pdb:2VSK|rcsb pdb:2VSM|rcsb pdb:2WO2|rcsb pdb:3GXU|rcsb pdb:4UF7|rcsb pdb:6P7Y|rcsb pdb:6PDL|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|dip:DIP-46378N	refseq:NP_001291465.1|refseq:NP_001291466.1|refseq:NP_004429.1|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|ensembl:ENST00000409938(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSG00000116106(gene)|ensembl:ENST00000281821(transcript)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106030"(neuron projection fasciculation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR030602|interpro:IPR034270|interpro:IPR036116|mint:P54764|rcsb pdb:2LW8|rcsb pdb:2WO1|interpro:IPR001660(Sterile alpha motif SAM)|rcsb pdb:2WO2|rcsb pdb:2WO3|rcsb pdb:3CKH|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:4BK4|rcsb pdb:4BK5|rcsb pdb:4BKA|rcsb pdb:4BKF|rcsb pdb:4M4P|rcsb pdb:4M4R|rcsb pdb:4W4Z|rcsb pdb:4W50|rcsb pdb:5JR2|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|rcsb pdb:3GXU|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048710"(regulation of astrocyte differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0090102"(cochlea development)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:0097161"(DH domain binding)|go:"GO:0097485"(neuron projection guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|dip:DIP-48294N	psi-mi:"MI:0465"(dip)	comment:mint|function:Binds to the receptor tyrosine kinases EPHB4 and EPHA3. May play a role in constraining the orientation of longitudinally projecting axons	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:Ie9xTJNgMD4VdbCiT9rJf1XCgqE9606	rogid:MYUpwpng4XICB/ea70FoGoG4b3I9606	rigid:UQhz09qe4WlIcaQi4ZJrnJHfPBk	false	binding-associated region:27-167	binding-associated region:30-202|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43921	uniprotkb:P54764	intact:EBI-8603210|ensembl:ENSP00000215368|intact:MINT-7013470|uniprotkb:O76020	intact:EBI-5773557|uniprotkb:A8K2P1|uniprotkb:B2R601|uniprotkb:B7Z6Q8|uniprotkb:Q2M380|ensembl:ENSP00000281821|ensembl:ENSP00000386829	psi-mi:efna2_human(display_long)|uniprotkb:EFNA2(gene name)|psi-mi:EFNA2(display_short)|uniprotkb:EPLG6(gene name synonym)|uniprotkb:LERK6(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 6(gene name synonym)|uniprotkb:HEK7 ligand(gene name synonym)	psi-mi:epha4_human(display_long)|uniprotkb:EPHA4(gene name)|psi-mi:EPHA4(display_short)|uniprotkb:EPH-like kinase 8(gene name synonym)|uniprotkb:HEK8(gene name synonym)|uniprotkb:SEK(gene name synonym)|uniprotkb:TYRO1(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor SEK(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Bowden et al. (2009)	pubmed:19836338|doi:10.1016/j.str.2009.07.018|imex:IM-11744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15810307|imex:IM-11744-4|dip:DIP-102506E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000099617(gene)|ensembl:ENST00000215368(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007411"(axon guidance)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043204"(perikaryon)|go:"GO:0046849"(bone remodeling)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|mint:O43921|rcsb pdb:2WO3|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|interpro:IPR034252|refseq:NP_001396.2|dip:DIP-48293N	refseq:NP_001291465.1|refseq:NP_001291466.1|refseq:NP_004429.1|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|ensembl:ENST00000409938(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSG00000116106(gene)|ensembl:ENST00000281821(transcript)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106030"(neuron projection fasciculation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR030602|interpro:IPR034270|interpro:IPR036116|mint:P54764|rcsb pdb:2LW8|rcsb pdb:2WO1|interpro:IPR001660(Sterile alpha motif SAM)|rcsb pdb:2WO2|rcsb pdb:2WO3|rcsb pdb:3CKH|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:4BK4|rcsb pdb:4BK5|rcsb pdb:4BKA|rcsb pdb:4BKF|rcsb pdb:4M4P|rcsb pdb:4M4R|rcsb pdb:4W4Z|rcsb pdb:4W50|rcsb pdb:5JR2|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|rcsb pdb:3GXU|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048710"(regulation of astrocyte differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0090102"(cochlea development)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:0097161"(DH domain binding)|go:"GO:0097485"(neuron projection guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|dip:DIP-48294N	psi-mi:"MI:0465"(dip)	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:De+pplhhYubxBerisbjO4oiMDAM9606	rogid:MYUpwpng4XICB/ea70FoGoG4b3I9606	rigid:qUfKbwdZTR/6jwCvHz9WR3BWv8s	false	binding-associated region:33-177	binding-associated region:30-202	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43921	uniprotkb:P54764	intact:EBI-8603210|ensembl:ENSP00000215368|intact:MINT-7013470|uniprotkb:O76020	intact:EBI-5773557|uniprotkb:A8K2P1|uniprotkb:B2R601|uniprotkb:B7Z6Q8|uniprotkb:Q2M380|ensembl:ENSP00000281821|ensembl:ENSP00000386829	psi-mi:efna2_human(display_long)|uniprotkb:EFNA2(gene name)|psi-mi:EFNA2(display_short)|uniprotkb:EPLG6(gene name synonym)|uniprotkb:LERK6(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 6(gene name synonym)|uniprotkb:HEK7 ligand(gene name synonym)	psi-mi:epha4_human(display_long)|uniprotkb:EPHA4(gene name)|psi-mi:EPHA4(display_short)|uniprotkb:EPH-like kinase 8(gene name synonym)|uniprotkb:HEK8(gene name synonym)|uniprotkb:SEK(gene name synonym)|uniprotkb:TYRO1(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor SEK(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Bowden et al. (2009)	pubmed:19836338|doi:10.1016/j.str.2009.07.018|imex:IM-11744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15810286|imex:IM-11744-3|dip:DIP-102506E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000099617(gene)|ensembl:ENST00000215368(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007411"(axon guidance)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043204"(perikaryon)|go:"GO:0046849"(bone remodeling)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|mint:O43921|rcsb pdb:2WO3|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|interpro:IPR034252|refseq:NP_001396.2|dip:DIP-48293N	refseq:NP_001291465.1|refseq:NP_001291466.1|refseq:NP_004429.1|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|ensembl:ENST00000409938(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSG00000116106(gene)|ensembl:ENST00000281821(transcript)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106030"(neuron projection fasciculation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR030602|interpro:IPR034270|interpro:IPR036116|mint:P54764|rcsb pdb:2LW8|rcsb pdb:2WO1|interpro:IPR001660(Sterile alpha motif SAM)|rcsb pdb:2WO2|rcsb pdb:2WO3|rcsb pdb:3CKH|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:4BK4|rcsb pdb:4BK5|rcsb pdb:4BKA|rcsb pdb:4BKF|rcsb pdb:4M4P|rcsb pdb:4M4R|rcsb pdb:4W4Z|rcsb pdb:4W50|rcsb pdb:5JR2|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|rcsb pdb:3GXU|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048710"(regulation of astrocyte differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0090102"(cochlea development)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:0097161"(DH domain binding)|go:"GO:0097485"(neuron projection guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|dip:DIP-48294N	psi-mi:"MI:0465"(dip)	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:De+pplhhYubxBerisbjO4oiMDAM9606	rogid:MYUpwpng4XICB/ea70FoGoG4b3I9606	rigid:qUfKbwdZTR/6jwCvHz9WR3BWv8s	false	binding-associated region:33-177	binding-associated region:30-202	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43921	uniprotkb:P54764	intact:EBI-8603210|ensembl:ENSP00000215368|intact:MINT-7013470|uniprotkb:O76020	intact:EBI-5773557|uniprotkb:A8K2P1|uniprotkb:B2R601|uniprotkb:B7Z6Q8|uniprotkb:Q2M380|ensembl:ENSP00000281821|ensembl:ENSP00000386829	psi-mi:efna2_human(display_long)|uniprotkb:EFNA2(gene name)|psi-mi:EFNA2(display_short)|uniprotkb:EPLG6(gene name synonym)|uniprotkb:LERK6(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 6(gene name synonym)|uniprotkb:HEK7 ligand(gene name synonym)	psi-mi:epha4_human(display_long)|uniprotkb:EPHA4(gene name)|psi-mi:EPHA4(display_short)|uniprotkb:EPH-like kinase 8(gene name synonym)|uniprotkb:HEK8(gene name synonym)|uniprotkb:SEK(gene name synonym)|uniprotkb:TYRO1(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor SEK(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Bowden et al. (2009)	pubmed:19836338|doi:10.1016/j.str.2009.07.018|imex:IM-11744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15810264|imex:IM-11744-2|dip:DIP-102506E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000099617(gene)|ensembl:ENST00000215368(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007411"(axon guidance)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043204"(perikaryon)|go:"GO:0046849"(bone remodeling)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|mint:O43921|rcsb pdb:2WO3|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|interpro:IPR034252|refseq:NP_001396.2|dip:DIP-48293N	refseq:NP_001291465.1|refseq:NP_001291466.1|refseq:NP_004429.1|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|ensembl:ENST00000409938(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSG00000116106(gene)|ensembl:ENST00000281821(transcript)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106030"(neuron projection fasciculation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR030602|interpro:IPR034270|interpro:IPR036116|mint:P54764|rcsb pdb:2LW8|rcsb pdb:2WO1|interpro:IPR001660(Sterile alpha motif SAM)|rcsb pdb:2WO2|rcsb pdb:2WO3|rcsb pdb:3CKH|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:4BK4|rcsb pdb:4BK5|rcsb pdb:4BKA|rcsb pdb:4BKF|rcsb pdb:4M4P|rcsb pdb:4M4R|rcsb pdb:4W4Z|rcsb pdb:4W50|rcsb pdb:5JR2|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|rcsb pdb:3GXU|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048710"(regulation of astrocyte differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0090102"(cochlea development)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:0097161"(DH domain binding)|go:"GO:0097485"(neuron projection guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|dip:DIP-48294N	psi-mi:"MI:0465"(dip)	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:De+pplhhYubxBerisbjO4oiMDAM9606	rogid:MYUpwpng4XICB/ea70FoGoG4b3I9606	rigid:qUfKbwdZTR/6jwCvHz9WR3BWv8s	false	binding-associated region:33-174	binding-associated region:30-202	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54764	uniprotkb:P52803	intact:EBI-5773557|uniprotkb:A8K2P1|uniprotkb:B2R601|uniprotkb:B7Z6Q8|uniprotkb:Q2M380|ensembl:ENSP00000281821|ensembl:ENSP00000386829	intact:EBI-1753674|ensembl:ENSP00000328777	psi-mi:epha4_human(display_long)|uniprotkb:EPHA4(gene name)|psi-mi:EPHA4(display_short)|uniprotkb:EPH-like kinase 8(gene name synonym)|uniprotkb:HEK8(gene name synonym)|uniprotkb:SEK(gene name synonym)|uniprotkb:TYRO1(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor SEK(gene name synonym)	psi-mi:efna5_human(display_long)|uniprotkb:EFNA5(gene name)|psi-mi:EFNA5(display_short)|uniprotkb:EPLG7(gene name synonym)|uniprotkb:LERK7(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 7(gene name synonym)|uniprotkb:AL-1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Bowden et al. (2009)	pubmed:19836338|doi:10.1016/j.str.2009.07.018|imex:IM-11744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15810328|imex:IM-11744-5|dip:DIP-102510E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001291465.1|refseq:NP_001291466.1|refseq:NP_004429.1|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|ensembl:ENST00000409938(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSG00000116106(gene)|ensembl:ENST00000281821(transcript)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106030"(neuron projection fasciculation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR030602|interpro:IPR034270|interpro:IPR036116|mint:P54764|rcsb pdb:2LW8|rcsb pdb:2WO1|interpro:IPR001660(Sterile alpha motif SAM)|rcsb pdb:2WO2|rcsb pdb:2WO3|rcsb pdb:3CKH|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:4BK4|rcsb pdb:4BK5|rcsb pdb:4BKA|rcsb pdb:4BKF|rcsb pdb:4M4P|rcsb pdb:4M4R|rcsb pdb:4W4Z|rcsb pdb:4W50|rcsb pdb:5JR2|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|rcsb pdb:3GXU|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048710"(regulation of astrocyte differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0090102"(cochlea development)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:0097161"(DH domain binding)|go:"GO:0097485"(neuron projection guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|dip:DIP-48294N	refseq:NP_001953.1|dip:DIP-48296N|ensembl:ENSG00000184349(gene)|ensembl:ENST00000333274(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005169"(neurotrophin TRKB receptor binding)|go:"GO:0005170"(neurotrophin TRKC receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|interpro:IPR034252|rcsb pdb:2X11|rcsb pdb:3MX0|rcsb pdb:4BK5|rcsb pdb:4BKA|rcsb pdb:4L0P|rcsb pdb:4M4R|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:MYUpwpng4XICB/ea70FoGoG4b3I9606	rogid:llcBvFrSFaqGGFHXs0ipOgtzAVk9606	rigid:7ufLIJx0qY9uj88a/CFfKDjgMg8	false	binding-associated region:30-202	binding-associated region:27-166	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54764	uniprotkb:P20827	intact:EBI-5773557|uniprotkb:A8K2P1|uniprotkb:B2R601|uniprotkb:B7Z6Q8|uniprotkb:Q2M380|ensembl:ENSP00000281821|ensembl:ENSP00000386829	intact:EBI-715194|uniprotkb:Q5SR60|uniprotkb:Q5SR61|uniprotkb:Q6I9T9|uniprotkb:Q8N578|ensembl:ENSP00000357392|uniprotkb:D3DV86	psi-mi:epha4_human(display_long)|uniprotkb:EPHA4(gene name)|psi-mi:EPHA4(display_short)|uniprotkb:EPH-like kinase 8(gene name synonym)|uniprotkb:HEK8(gene name synonym)|uniprotkb:SEK(gene name synonym)|uniprotkb:TYRO1(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor SEK(gene name synonym)	psi-mi:efna1_human(display_long)|uniprotkb:EPH-related receptor tyrosine kinase ligand 1(gene name synonym)|uniprotkb:Immediate early response protein B61(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 4(gene name synonym)|uniprotkb:EFNA1(gene name)|psi-mi:EFNA1(display_short)|uniprotkb:EPLG1(gene name synonym)|uniprotkb:LERK1(gene name synonym)|uniprotkb:TNFAIP4(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Bowden et al. (2009)	pubmed:19836338|doi:10.1016/j.str.2009.07.018|imex:IM-11744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15810349|imex:IM-11744-6|dip:DIP-102508E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001291465.1|refseq:NP_001291466.1|refseq:NP_004429.1|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|ensembl:ENST00000409938(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSG00000116106(gene)|ensembl:ENST00000281821(transcript)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106030"(neuron projection fasciculation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR030602|interpro:IPR034270|interpro:IPR036116|mint:P54764|rcsb pdb:2LW8|rcsb pdb:2WO1|interpro:IPR001660(Sterile alpha motif SAM)|rcsb pdb:2WO2|rcsb pdb:2WO3|rcsb pdb:3CKH|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:4BK4|rcsb pdb:4BK5|rcsb pdb:4BKA|rcsb pdb:4BKF|rcsb pdb:4M4P|rcsb pdb:4M4R|rcsb pdb:4W4Z|rcsb pdb:4W50|rcsb pdb:5JR2|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|rcsb pdb:3GXU|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048710"(regulation of astrocyte differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0090102"(cochlea development)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:0097161"(DH domain binding)|go:"GO:0097485"(neuron projection guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|dip:DIP-48294N	refseq:NP_004419.2|refseq:NP_872626.1|ensembl:ENSG00000169242(gene)|ensembl:ENST00000368407(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003199"(endocardial cushion to mesenchymal transition involved in heart valve formation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007411"(axon guidance)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0014028"(notochord formation)|go:"GO:0016477"(cell migration)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|interpro:IPR034252|mint:P20827|rcsb pdb:3CZU|rcsb pdb:3HEI|rcsb pdb:3MBW|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|dip:DIP-98N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:MYUpwpng4XICB/ea70FoGoG4b3I9606	rogid:buRAXjFXXzsg7OXYzU5snuQy5w09606	rigid:ytRyuKmscn6tJbQ4lmII2x7aAaU	false	binding-associated region:30-202	binding-associated region:16-158	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52799	uniprotkb:P54764	intact:EBI-7532268|intact:MINT-3019741|uniprotkb:Q5JV56|ensembl:ENSP00000493716	intact:EBI-5773557|uniprotkb:A8K2P1|uniprotkb:B2R601|uniprotkb:B7Z6Q8|uniprotkb:Q2M380|ensembl:ENSP00000281821|ensembl:ENSP00000386829	psi-mi:efnb2_human(display_long)|uniprotkb:EFNB2(gene name)|psi-mi:EFNB2(display_short)|uniprotkb:EPLG5(gene name synonym)|uniprotkb:HTKL(gene name synonym)|uniprotkb:LERK5(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 5(gene name synonym)|uniprotkb:HTK ligand(gene name synonym)	psi-mi:epha4_human(display_long)|uniprotkb:EPHA4(gene name)|psi-mi:EPHA4(display_short)|uniprotkb:EPH-like kinase 8(gene name synonym)|uniprotkb:HEK8(gene name synonym)|uniprotkb:SEK(gene name synonym)|uniprotkb:TYRO1(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor SEK(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Bowden et al. (2009)	pubmed:19836338|doi:10.1016/j.str.2009.07.018|imex:IM-11744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15810436|imex:IM-11744-10|dip:DIP-102507E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004084.1|ensembl:ENSG00000125266(gene)|ensembl:ENST00000646441(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|interpro:IPR034255|mint:P52799|rcsb pdb:2HLE|rcsb pdb:2I85|rcsb pdb:2VSK|rcsb pdb:2VSM|rcsb pdb:2WO2|rcsb pdb:3GXU|rcsb pdb:4UF7|rcsb pdb:6P7Y|rcsb pdb:6PDL|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|dip:DIP-46378N	refseq:NP_001291465.1|refseq:NP_001291466.1|refseq:NP_004429.1|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|ensembl:ENST00000409938(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSG00000116106(gene)|ensembl:ENST00000281821(transcript)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106030"(neuron projection fasciculation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR030602|interpro:IPR034270|interpro:IPR036116|mint:P54764|rcsb pdb:2LW8|rcsb pdb:2WO1|interpro:IPR001660(Sterile alpha motif SAM)|rcsb pdb:2WO2|rcsb pdb:2WO3|rcsb pdb:3CKH|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:4BK4|rcsb pdb:4BK5|rcsb pdb:4BKA|rcsb pdb:4BKF|rcsb pdb:4M4P|rcsb pdb:4M4R|rcsb pdb:4W4Z|rcsb pdb:4W50|rcsb pdb:5JR2|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|rcsb pdb:3GXU|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048710"(regulation of astrocyte differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0090102"(cochlea development)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:0097161"(DH domain binding)|go:"GO:0097485"(neuron projection guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|dip:DIP-48294N	psi-mi:"MI:0465"(dip)	comment:mint|function:Binds to the receptor tyrosine kinases EPHB4 and EPHA3. May play a role in constraining the orientation of longitudinally projecting axons	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:Ie9xTJNgMD4VdbCiT9rJf1XCgqE9606	rogid:MYUpwpng4XICB/ea70FoGoG4b3I9606	rigid:UQhz09qe4WlIcaQi4ZJrnJHfPBk	false	binding-associated region:27-167	binding-associated region:30-202	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52799	uniprotkb:P54764	intact:EBI-7532268|intact:MINT-3019741|uniprotkb:Q5JV56|ensembl:ENSP00000493716	intact:EBI-5773557|uniprotkb:A8K2P1|uniprotkb:B2R601|uniprotkb:B7Z6Q8|uniprotkb:Q2M380|ensembl:ENSP00000281821|ensembl:ENSP00000386829	psi-mi:efnb2_human(display_long)|uniprotkb:EFNB2(gene name)|psi-mi:EFNB2(display_short)|uniprotkb:EPLG5(gene name synonym)|uniprotkb:HTKL(gene name synonym)|uniprotkb:LERK5(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 5(gene name synonym)|uniprotkb:HTK ligand(gene name synonym)	psi-mi:epha4_human(display_long)|uniprotkb:EPHA4(gene name)|psi-mi:EPHA4(display_short)|uniprotkb:EPH-like kinase 8(gene name synonym)|uniprotkb:HEK8(gene name synonym)|uniprotkb:SEK(gene name synonym)|uniprotkb:TYRO1(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor SEK(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Bowden et al. (2009)	pubmed:19836338|doi:10.1016/j.str.2009.07.018|imex:IM-11744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15810414|imex:IM-11744-9|dip:DIP-102507E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004084.1|ensembl:ENSG00000125266(gene)|ensembl:ENST00000646441(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|interpro:IPR034255|mint:P52799|rcsb pdb:2HLE|rcsb pdb:2I85|rcsb pdb:2VSK|rcsb pdb:2VSM|rcsb pdb:2WO2|rcsb pdb:3GXU|rcsb pdb:4UF7|rcsb pdb:6P7Y|rcsb pdb:6PDL|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|dip:DIP-46378N	refseq:NP_001291465.1|refseq:NP_001291466.1|refseq:NP_004429.1|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|ensembl:ENST00000409938(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSG00000116106(gene)|ensembl:ENST00000281821(transcript)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106030"(neuron projection fasciculation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR030602|interpro:IPR034270|interpro:IPR036116|mint:P54764|rcsb pdb:2LW8|rcsb pdb:2WO1|interpro:IPR001660(Sterile alpha motif SAM)|rcsb pdb:2WO2|rcsb pdb:2WO3|rcsb pdb:3CKH|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:4BK4|rcsb pdb:4BK5|rcsb pdb:4BKA|rcsb pdb:4BKF|rcsb pdb:4M4P|rcsb pdb:4M4R|rcsb pdb:4W4Z|rcsb pdb:4W50|rcsb pdb:5JR2|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|rcsb pdb:3GXU|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048710"(regulation of astrocyte differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0090102"(cochlea development)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:0097161"(DH domain binding)|go:"GO:0097485"(neuron projection guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|dip:DIP-48294N	psi-mi:"MI:0465"(dip)	comment:mint|function:Binds to the receptor tyrosine kinases EPHB4 and EPHA3. May play a role in constraining the orientation of longitudinally projecting axons	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:Ie9xTJNgMD4VdbCiT9rJf1XCgqE9606	rogid:MYUpwpng4XICB/ea70FoGoG4b3I9606	rigid:UQhz09qe4WlIcaQi4ZJrnJHfPBk	false	binding-associated region:27-167	binding-associated region:30-202	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43921	uniprotkb:P54764	intact:EBI-8603210|ensembl:ENSP00000215368|intact:MINT-7013470|uniprotkb:O76020	intact:EBI-5773557|uniprotkb:A8K2P1|uniprotkb:B2R601|uniprotkb:B7Z6Q8|uniprotkb:Q2M380|ensembl:ENSP00000281821|ensembl:ENSP00000386829	psi-mi:efna2_human(display_long)|uniprotkb:EFNA2(gene name)|psi-mi:EFNA2(display_short)|uniprotkb:EPLG6(gene name synonym)|uniprotkb:LERK6(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 6(gene name synonym)|uniprotkb:HEK7 ligand(gene name synonym)	psi-mi:epha4_human(display_long)|uniprotkb:EPHA4(gene name)|psi-mi:EPHA4(display_short)|uniprotkb:EPH-like kinase 8(gene name synonym)|uniprotkb:HEK8(gene name synonym)|uniprotkb:SEK(gene name synonym)|uniprotkb:TYRO1(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor SEK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bowden et al. (2009)	pubmed:19836338|doi:10.1016/j.str.2009.07.018|imex:IM-11744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15810391|imex:IM-11744-8|dip:DIP-102506E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000099617(gene)|ensembl:ENST00000215368(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007411"(axon guidance)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043204"(perikaryon)|go:"GO:0046849"(bone remodeling)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|mint:O43921|rcsb pdb:2WO3|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|interpro:IPR034252|refseq:NP_001396.2|dip:DIP-48293N	refseq:NP_001291465.1|refseq:NP_001291466.1|refseq:NP_004429.1|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|ensembl:ENST00000409938(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSG00000116106(gene)|ensembl:ENST00000281821(transcript)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106030"(neuron projection fasciculation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR030602|interpro:IPR034270|interpro:IPR036116|mint:P54764|rcsb pdb:2LW8|rcsb pdb:2WO1|interpro:IPR001660(Sterile alpha motif SAM)|rcsb pdb:2WO2|rcsb pdb:2WO3|rcsb pdb:3CKH|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:4BK4|rcsb pdb:4BK5|rcsb pdb:4BKA|rcsb pdb:4BKF|rcsb pdb:4M4P|rcsb pdb:4M4R|rcsb pdb:4W4Z|rcsb pdb:4W50|rcsb pdb:5JR2|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|rcsb pdb:3GXU|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048710"(regulation of astrocyte differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0090102"(cochlea development)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:0097161"(DH domain binding)|go:"GO:0097485"(neuron projection guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|dip:DIP-48294N	psi-mi:"MI:0465"(dip)	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:De+pplhhYubxBerisbjO4oiMDAM9606	rogid:MYUpwpng4XICB/ea70FoGoG4b3I9606	rigid:qUfKbwdZTR/6jwCvHz9WR3BWv8s	false	binding-associated region:33-177	binding-associated region:30-202|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52799	uniprotkb:P54764	intact:EBI-7532268|intact:MINT-3019741|uniprotkb:Q5JV56|ensembl:ENSP00000493716	intact:EBI-5773557|uniprotkb:A8K2P1|uniprotkb:B2R601|uniprotkb:B7Z6Q8|uniprotkb:Q2M380|ensembl:ENSP00000281821|ensembl:ENSP00000386829	psi-mi:efnb2_human(display_long)|uniprotkb:EFNB2(gene name)|psi-mi:EFNB2(display_short)|uniprotkb:EPLG5(gene name synonym)|uniprotkb:HTKL(gene name synonym)|uniprotkb:LERK5(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 5(gene name synonym)|uniprotkb:HTK ligand(gene name synonym)	psi-mi:epha4_human(display_long)|uniprotkb:EPHA4(gene name)|psi-mi:EPHA4(display_short)|uniprotkb:EPH-like kinase 8(gene name synonym)|uniprotkb:HEK8(gene name synonym)|uniprotkb:SEK(gene name synonym)|uniprotkb:TYRO1(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor SEK(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Bowden et al. (2009)	pubmed:19836338|doi:10.1016/j.str.2009.07.018|imex:IM-11744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15810370|imex:IM-11744-7|dip:DIP-102507E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004084.1|ensembl:ENSG00000125266(gene)|ensembl:ENST00000646441(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|interpro:IPR034255|mint:P52799|rcsb pdb:2HLE|rcsb pdb:2I85|rcsb pdb:2VSK|rcsb pdb:2VSM|rcsb pdb:2WO2|rcsb pdb:3GXU|rcsb pdb:4UF7|rcsb pdb:6P7Y|rcsb pdb:6PDL|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|dip:DIP-46378N	refseq:NP_001291465.1|refseq:NP_001291466.1|refseq:NP_004429.1|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|ensembl:ENST00000409938(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSG00000116106(gene)|ensembl:ENST00000281821(transcript)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106030"(neuron projection fasciculation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR030602|interpro:IPR034270|interpro:IPR036116|mint:P54764|rcsb pdb:2LW8|rcsb pdb:2WO1|interpro:IPR001660(Sterile alpha motif SAM)|rcsb pdb:2WO2|rcsb pdb:2WO3|rcsb pdb:3CKH|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:4BK4|rcsb pdb:4BK5|rcsb pdb:4BKA|rcsb pdb:4BKF|rcsb pdb:4M4P|rcsb pdb:4M4R|rcsb pdb:4W4Z|rcsb pdb:4W50|rcsb pdb:5JR2|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|rcsb pdb:3GXU|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048710"(regulation of astrocyte differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0090102"(cochlea development)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:0097161"(DH domain binding)|go:"GO:0097485"(neuron projection guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|dip:DIP-48294N	psi-mi:"MI:0465"(dip)	comment:mint|function:Binds to the receptor tyrosine kinases EPHB4 and EPHA3. May play a role in constraining the orientation of longitudinally projecting axons	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:Ie9xTJNgMD4VdbCiT9rJf1XCgqE9606	rogid:MYUpwpng4XICB/ea70FoGoG4b3I9606	rigid:UQhz09qe4WlIcaQi4ZJrnJHfPBk	false	binding-associated region:25-168	binding-associated region:30-202	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54764	uniprotkb:P52798	intact:EBI-5773557|uniprotkb:A8K2P1|uniprotkb:B2R601|uniprotkb:B7Z6Q8|uniprotkb:Q2M380|ensembl:ENSP00000281821|ensembl:ENSP00000386829	intact:EBI-5241592|uniprotkb:C9JHJ8|uniprotkb:O95457|uniprotkb:Q5SR71|uniprotkb:Q6FI57|uniprotkb:G3XAK2|ensembl:ENSP00000357394	psi-mi:epha4_human(display_long)|uniprotkb:EPHA4(gene name)|psi-mi:EPHA4(display_short)|uniprotkb:EPH-like kinase 8(gene name synonym)|uniprotkb:HEK8(gene name synonym)|uniprotkb:SEK(gene name synonym)|uniprotkb:TYRO1(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor SEK(gene name synonym)	psi-mi:efna4_human(display_long)|uniprotkb:EFNA4(gene name)|psi-mi:EFNA4(display_short)|uniprotkb:EPLG4(gene name synonym)|uniprotkb:LERK4(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 4(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Bowden et al. (2009)	pubmed:19836338|doi:10.1016/j.str.2009.07.018|imex:IM-11744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15810457|imex:IM-11744-11|dip:DIP-102509E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001291465.1|refseq:NP_001291466.1|refseq:NP_004429.1|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|ensembl:ENST00000409938(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSG00000116106(gene)|ensembl:ENST00000281821(transcript)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106030"(neuron projection fasciculation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR030602|interpro:IPR034270|interpro:IPR036116|mint:P54764|rcsb pdb:2LW8|rcsb pdb:2WO1|interpro:IPR001660(Sterile alpha motif SAM)|rcsb pdb:2WO2|rcsb pdb:2WO3|rcsb pdb:3CKH|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:4BK4|rcsb pdb:4BK5|rcsb pdb:4BKA|rcsb pdb:4BKF|rcsb pdb:4M4P|rcsb pdb:4M4R|rcsb pdb:4W4Z|rcsb pdb:4W50|rcsb pdb:5JR2|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|rcsb pdb:3GXU|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048710"(regulation of astrocyte differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0090102"(cochlea development)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:0097161"(DH domain binding)|go:"GO:0097485"(neuron projection guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|dip:DIP-48294N	refseq:NP_005218.1|refseq:NP_872632.2|refseq:NP_872631.1|dip:DIP-48295N|ensembl:ENSG00000243364(gene)|ensembl:ENST00000368409(transcript)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007411"(axon guidance)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|interpro:IPR034252|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:MYUpwpng4XICB/ea70FoGoG4b3I9606	rogid:+3ai+xRmqOWQ0WW1xzO2744VQK09606	rigid:0Nf2mvkaTZn1/6ZV7YsunFWLMcI	false	binding-associated region:30-202	binding-associated region:23-162	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)