#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q68EF4	uniprotkb:O08599	intact:EBI-15809151|uniprotkb:Q80UC2	intact:EBI-445322|uniprotkb:A2ARS2|uniprotkb:A2ARS3|uniprotkb:A2ARS4|uniprotkb:Q5WAC6|uniprotkb:Q8VD51|ensembl:ENSMUSP00000052440	psi-mi:grm4_mouse(display_long)|uniprotkb:Grm4(gene name)|psi-mi:Grm4(display_short)|uniprotkb:Gprc1d(gene name synonym)|uniprotkb:Mglur4(gene name synonym)	psi-mi:stxb1_mouse(display_long)|uniprotkb:Protein unc-18 homolog 1(gene name synonym)|uniprotkb:Protein unc-18 homolog A(gene name synonym)|uniprotkb:Stxbp1(gene name)|psi-mi:Stxbp1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Nakajima et al. (2009)	pubmed:19822743|doi:10.1073/pnas.0910088106|imex:IM-14856	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15809182|imex:IM-14856-2|dip:DIP-104179E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001786(GPCR, family 3, metabotropic glutamate receptor 4)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001642"(group III metabotropic glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007196"(adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:0043198"(dendritic shaft)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048787"(presynaptic active zone membrane)|reactome:R-MMU-418594|reactome:R-MMU-420499|refseq:NP_001013403.1|dip:DIP-49002N	refseq:NP_001107041.1|refseq:NP_033321.2|interpro:IPR043127|interpro:IPR043154|mint:O08599|go:"GO:0098794"(postsynapse)|go:"GO:0098891"(extrinsic component of presynaptic active zone membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099525"(presynaptic dense core vesicle exocytosis)|reactome:R-MMU-181429|reactome:R-MMU-181430|go:"GO:0106022"(positive regulation of vesicle docking)|go:"GO:1903296"(positive regulation of glutamate secretion, neurotransmission)|go:"GO:2000367"(regulation of acrosomal vesicle exocytosis)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|reactome:R-MMU-210500|reactome:R-MMU-212676|reactome:R-MMU-264642|reactome:R-MMU-888590|ensembl:ENSMUSG00000026797(gene)|ensembl:ENSMUST00000050000(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0002576"(platelet degranulation)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007412"(axon target recognition)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030424"(axon)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031338"(regulation of vesicle fusion)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050821"(protein stabilization)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|dip:DIP-31951N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:YyzCS0VeGoh92zPBZEKAQdul7Kw10090	rogid:yUYi89hDkfMdQ1BdH52swZQFCLk10090	rigid:Mx8A3W5peSFkGCXwN210svQp6fs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35400	uniprotkb:O08599	intact:EBI-6936416|intact:MINT-146474	intact:EBI-445322|uniprotkb:A2ARS2|uniprotkb:A2ARS3|uniprotkb:A2ARS4|uniprotkb:Q5WAC6|uniprotkb:Q8VD51|ensembl:ENSMUSP00000052440	psi-mi:grm7_rat(display_long)|uniprotkb:Grm7(gene name)|psi-mi:Grm7(display_short)|uniprotkb:Gprc1g(gene name synonym)|uniprotkb:Mglur7(gene name synonym)	psi-mi:stxb1_mouse(display_long)|uniprotkb:Protein unc-18 homolog 1(gene name synonym)|uniprotkb:Protein unc-18 homolog A(gene name synonym)|uniprotkb:Stxbp1(gene name)|psi-mi:Stxbp1(display_short)	psi-mi:"MI:0096"(pull down)	Nakajima et al. (2009)	pubmed:19822743|doi:10.1073/pnas.0910088106|imex:IM-14856	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15809130|imex:IM-14856-1|dip:DIP-104178E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007196"(adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007614"(short-term memory)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010855"(adenylate cyclase inhibitor activity)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050877"(nervous system process)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0061564"(axon development)|go:"GO:0070085"(glycosylation)|go:"GO:0070905"(serine binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR001883(GPCR, family 3, metabotropic glutamate receptor 7)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|rcsb pdb:2E4Z|reactome:R-RNO-418594|reactome:R-RNO-420499|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001642"(group III metabotropic glutamate receptor activity)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|refseq:NP_112302.1|rgd:619857|mint:P35400|dip:DIP-41145N	refseq:NP_001107041.1|refseq:NP_033321.2|interpro:IPR043127|interpro:IPR043154|mint:O08599|go:"GO:0098794"(postsynapse)|go:"GO:0098891"(extrinsic component of presynaptic active zone membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099525"(presynaptic dense core vesicle exocytosis)|reactome:R-MMU-181429|reactome:R-MMU-181430|go:"GO:0106022"(positive regulation of vesicle docking)|go:"GO:1903296"(positive regulation of glutamate secretion, neurotransmission)|go:"GO:2000367"(regulation of acrosomal vesicle exocytosis)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|reactome:R-MMU-210500|reactome:R-MMU-212676|reactome:R-MMU-264642|reactome:R-MMU-888590|ensembl:ENSMUSG00000026797(gene)|ensembl:ENSMUST00000050000(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0002576"(platelet degranulation)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007412"(axon target recognition)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030424"(axon)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031338"(regulation of vesicle fusion)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050821"(protein stabilization)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|dip:DIP-31951N	psi-mi:"MI:0465"(dip)	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:4p27GEshqsLLsQueJLDdVAXV6BY10116	rogid:yUYi89hDkfMdQ1BdH52swZQFCLk10090	rigid:xBGIc1OQ7VCRQwzW8mMuhWIgcbY	false	glutathione s tranferase tag:n-n|binding-associated region:851-915	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q68ED2	uniprotkb:O08599	intact:EBI-770638|ensembl:ENSMUSP00000133957	intact:EBI-445322|uniprotkb:A2ARS2|uniprotkb:A2ARS3|uniprotkb:A2ARS4|uniprotkb:Q5WAC6|uniprotkb:Q8VD51|ensembl:ENSMUSP00000052440	psi-mi:grm7_mouse(display_long)|uniprotkb:Grm7(gene name)|psi-mi:Grm7(display_short)|uniprotkb:Gprc1g(gene name synonym)|uniprotkb:Mglur7(gene name synonym)	psi-mi:stxb1_mouse(display_long)|uniprotkb:Protein unc-18 homolog 1(gene name synonym)|uniprotkb:Protein unc-18 homolog A(gene name synonym)|uniprotkb:Stxbp1(gene name)|psi-mi:Stxbp1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Nakajima et al. (2009)	pubmed:19822743|doi:10.1073/pnas.0910088106|imex:IM-14856	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15809199|imex:IM-14856-3|dip:DIP-104180E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_796302.2|dip:DIP-32216N|ensembl:ENSMUSG00000056755(gene)|ensembl:ENSMUST00000172951(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001642"(group III metabotropic glutamate receptor activity)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007196"(adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007613"(memory)|go:"GO:0007614"(short-term memory)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010855"(adenylate cyclase inhibitor activity)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0061564"(axon development)|go:"GO:0070085"(glycosylation)|go:"GO:0070905"(serine binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR001883(GPCR, family 3, metabotropic glutamate receptor 7)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|reactome:R-MMU-418594|reactome:R-MMU-420499	refseq:NP_001107041.1|refseq:NP_033321.2|interpro:IPR043127|interpro:IPR043154|mint:O08599|go:"GO:0098794"(postsynapse)|go:"GO:0098891"(extrinsic component of presynaptic active zone membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099525"(presynaptic dense core vesicle exocytosis)|reactome:R-MMU-181429|reactome:R-MMU-181430|go:"GO:0106022"(positive regulation of vesicle docking)|go:"GO:1903296"(positive regulation of glutamate secretion, neurotransmission)|go:"GO:2000367"(regulation of acrosomal vesicle exocytosis)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|reactome:R-MMU-210500|reactome:R-MMU-212676|reactome:R-MMU-264642|reactome:R-MMU-888590|ensembl:ENSMUSG00000026797(gene)|ensembl:ENSMUST00000050000(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0002576"(platelet degranulation)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007412"(axon target recognition)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030424"(axon)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031338"(regulation of vesicle fusion)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050821"(protein stabilization)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|dip:DIP-31951N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:xRI8IosXBXZi9+Ede5pJo5e7JeY10090	rogid:yUYi89hDkfMdQ1BdH52swZQFCLk10090	rigid:UAUOH0V1Shzp2w7T9q0XS9kbNbc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35400	uniprotkb:O08599-1	intact:EBI-6936416|intact:MINT-146474	intact:EBI-15809216|ensembl:ENSMUSP00000052440	psi-mi:grm7_rat(display_long)|uniprotkb:Grm7(gene name)|psi-mi:Grm7(display_short)|uniprotkb:Gprc1g(gene name synonym)|uniprotkb:Mglur7(gene name synonym)	psi-mi:o08599-1(display_long)|uniprotkb:Stxbp1(gene name)|psi-mi:Stxbp1(display_short)|uniprotkb:Protein unc-18 homolog 1(gene name synonym)|uniprotkb:Protein unc-18 homolog A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Nakajima et al. (2009)	pubmed:19822743|doi:10.1073/pnas.0910088106|imex:IM-14856	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15809248|imex:IM-14856-5|dip:DIP-104178E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007196"(adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007614"(short-term memory)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010855"(adenylate cyclase inhibitor activity)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050877"(nervous system process)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0061564"(axon development)|go:"GO:0070085"(glycosylation)|go:"GO:0070905"(serine binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR001883(GPCR, family 3, metabotropic glutamate receptor 7)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|rcsb pdb:2E4Z|reactome:R-RNO-418594|reactome:R-RNO-420499|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001642"(group III metabotropic glutamate receptor activity)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|refseq:NP_112302.1|rgd:619857|mint:P35400|dip:DIP-41145N	ensembl:ENSMUSG00000026797(gene)|ensembl:ENSMUST00000050000(transcript)|intact:EBI-445322(isoform-parent)	psi-mi:"MI:0465"(dip)	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:4p27GEshqsLLsQueJLDdVAXV6BY10116	rogid:yUYi89hDkfMdQ1BdH52swZQFCLk10090	rigid:xBGIc1OQ7VCRQwzW8mMuhWIgcbY	false	binding-associated region:851-915|glutathione s tranferase tag:n-n	his tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P31423	uniprotkb:O08599-1	intact:EBI-7974891|intact:MINT-235145	intact:EBI-15809216|ensembl:ENSMUSP00000052440	psi-mi:grm4_rat(display_long)|uniprotkb:Grm4(gene name)|psi-mi:Grm4(display_short)|uniprotkb:Gprc1d(gene name synonym)|uniprotkb:Mglur4(gene name synonym)	psi-mi:o08599-1(display_long)|uniprotkb:Stxbp1(gene name)|psi-mi:Stxbp1(display_short)|uniprotkb:Protein unc-18 homolog 1(gene name synonym)|uniprotkb:Protein unc-18 homolog A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Nakajima et al. (2009)	pubmed:19822743|doi:10.1073/pnas.0910088106|imex:IM-14856	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15809223|imex:IM-14856-4|dip:DIP-104181E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2745|refseq:NP_073157.1|dip:DIP-41144N|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007196"(adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014051"(gamma-aminobutyric acid secretion)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|mint:P31423|interpro:IPR000337(GPCR, family 3)|interpro:IPR001786(GPCR, family 3, metabotropic glutamate receptor 4)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|reactome:R-RNO-418594|reactome:R-RNO-420499	ensembl:ENSMUSG00000026797(gene)|ensembl:ENSMUST00000050000(transcript)|intact:EBI-445322(isoform-parent)	psi-mi:"MI:0465"(dip)	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:Q+SUUFPoCxp8dLjZM9SC2wvqS4M10116	rogid:yUYi89hDkfMdQ1BdH52swZQFCLk10090	rigid:9WZjgUPZ1w4oEdjFCjQHeNguwKU	false	glutathione s tranferase tag:n-n|sufficient binding region:848-889	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31423	uniprotkb:O08599-1	intact:EBI-7974891|intact:MINT-235145	intact:EBI-15809216|ensembl:ENSMUSP00000052440	psi-mi:grm4_rat(display_long)|uniprotkb:Grm4(gene name)|psi-mi:Grm4(display_short)|uniprotkb:Gprc1d(gene name synonym)|uniprotkb:Mglur4(gene name synonym)	psi-mi:o08599-1(display_long)|uniprotkb:Stxbp1(gene name)|psi-mi:Stxbp1(display_short)|uniprotkb:Protein unc-18 homolog 1(gene name synonym)|uniprotkb:Protein unc-18 homolog A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Nakajima et al. (2009)	pubmed:19822743|doi:10.1073/pnas.0910088106|imex:IM-14856	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15809273|imex:IM-14856-6|dip:DIP-104181E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2745|refseq:NP_073157.1|dip:DIP-41144N|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007196"(adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014051"(gamma-aminobutyric acid secretion)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|mint:P31423|interpro:IPR000337(GPCR, family 3)|interpro:IPR001786(GPCR, family 3, metabotropic glutamate receptor 4)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|reactome:R-RNO-418594|reactome:R-RNO-420499	ensembl:ENSMUSG00000026797(gene)|ensembl:ENSMUST00000050000(transcript)|intact:EBI-445322(isoform-parent)	psi-mi:"MI:0465"(dip)	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:Q+SUUFPoCxp8dLjZM9SC2wvqS4M10116	rogid:yUYi89hDkfMdQ1BdH52swZQFCLk10090	rigid:9WZjgUPZ1w4oEdjFCjQHeNguwKU	false	binding-associated region:848-912|glutathione s tranferase tag:n-n	his tag:?-?|sufficient binding region:1-134	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)