#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9BXL7 uniprotkb:Q13191-1 intact:EBI-7006141|intact:EBI-28969961|ensembl:ENSP00000380150|uniprotkb:Q2NKN7|intact:MINT-193901|uniprotkb:A4D1Z7|uniprotkb:Q548H3 intact:EBI-15555129|ensembl:ENSP00000377598 psi-mi:car11_human(display_long)|uniprotkb:CARD11(gene name)|psi-mi:CARD11(display_short)|uniprotkb:CARMA1(gene name synonym)|uniprotkb:CARD-containing MAGUK protein 1(gene name synonym) psi-mi:q13191-1(display_long)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING finger protein 56(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:Nbla00127(orf name)|uniprotkb:CBLB(gene name)|psi-mi:CBLB(display_short)|uniprotkb:RNF56(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kojo et al. (2009) pubmed:19815501|doi:10.1073/pnas.0904078106|imex:IM-14850 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15808312|imex:IM-14850-3|dip:DIP-104165E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000380150|refseq:NP_001311210.1|refseq:XP_011513888.1|ensembl:ENSG00000198286(gene)|ensembl:ENST00000396946(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032449"(CBM complex)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045121"(membrane raft)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR033538|interpro:IPR036034|interpro:IPR042141|mint:Q9BXL7|rcsb pdb:4JUP|rcsb pdb:4LWD|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|refseq:NP_115791.3|dip:DIP-41797N ensembl:ENSG00000114423(gene)|ensembl:ENST00000394030(transcript)|intact:EBI-744027(isoform-parent) psi-mi:"MI:0465"(dip) comment:mint|comment:homomint|function:Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10 - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:6Brt3NrkQt4m0X6OTPgixpH3E5w9606 rogid:cJ5eLH0TMyM6OtmS1sM3rhsrsIk9606 rigid:UKEUae6fKI6dK47+YVVHhl3rcFM false flag tag:n-n tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9BXL7 uniprotkb:Q13191-1 intact:EBI-7006141|intact:EBI-28969961|ensembl:ENSP00000380150|uniprotkb:Q2NKN7|intact:MINT-193901|uniprotkb:A4D1Z7|uniprotkb:Q548H3 intact:EBI-15555129|ensembl:ENSP00000377598 psi-mi:car11_human(display_long)|uniprotkb:CARD11(gene name)|psi-mi:CARD11(display_short)|uniprotkb:CARMA1(gene name synonym)|uniprotkb:CARD-containing MAGUK protein 1(gene name synonym) psi-mi:q13191-1(display_long)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING finger protein 56(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:Nbla00127(orf name)|uniprotkb:CBLB(gene name)|psi-mi:CBLB(display_short)|uniprotkb:RNF56(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kojo et al. (2009) pubmed:19815501|doi:10.1073/pnas.0904078106|imex:IM-14850 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15808291|imex:IM-14850-2|dip:DIP-104165E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000380150|refseq:NP_001311210.1|refseq:XP_011513888.1|ensembl:ENSG00000198286(gene)|ensembl:ENST00000396946(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032449"(CBM complex)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045121"(membrane raft)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR033538|interpro:IPR036034|interpro:IPR042141|mint:Q9BXL7|rcsb pdb:4JUP|rcsb pdb:4LWD|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|refseq:NP_115791.3|dip:DIP-41797N ensembl:ENSG00000114423(gene)|ensembl:ENST00000394030(transcript)|intact:EBI-744027(isoform-parent) psi-mi:"MI:0465"(dip) comment:mint|comment:homomint|function:Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10 - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:6Brt3NrkQt4m0X6OTPgixpH3E5w9606 rogid:cJ5eLH0TMyM6OtmS1sM3rhsrsIk9606 rigid:UKEUae6fKI6dK47+YVVHhl3rcFM false flag tag:n-n ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P49116 uniprotkb:Q13191-1 intact:EBI-2652582|uniprotkb:A8K3H5|uniprotkb:P55092|uniprotkb:B6ZGT8|ensembl:ENSP00000376814|ensembl:ENSP00000384463|ensembl:ENSP00000388387 intact:EBI-15555129|ensembl:ENSP00000377598 psi-mi:nr2c2_human(display_long)|uniprotkb:NR2C2(gene name)|psi-mi:NR2C2(display_short)|uniprotkb:TAK1(gene name synonym)|uniprotkb:TR4(gene name synonym)|uniprotkb:Orphan nuclear receptor TR4(gene name synonym)|uniprotkb:Testicular receptor 4(gene name synonym)|uniprotkb:Orphan nuclear receptor TAK1(gene name synonym) psi-mi:q13191-1(display_long)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING finger protein 56(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:Nbla00127(orf name)|uniprotkb:CBLB(gene name)|psi-mi:CBLB(display_short)|uniprotkb:RNF56(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kojo et al. (2009) pubmed:19815501|doi:10.1073/pnas.0904078106|imex:IM-14850 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15808270|imex:IM-14850-1|dip:DIP-104167E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003289.2|refseq:NP_001278623.1|ensembl:ENSG00000177463(gene)|ensembl:ENST00000393102(transcript)|ensembl:ENST00000406272(transcript)|ensembl:ENST00000425241(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048856"(anatomical structure development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P49116|rcsb pdb:3P0U|reactome:R-HSA-383280|refseq:XP_016862609.1|dip:DIP-5999N ensembl:ENSG00000114423(gene)|ensembl:ENST00000394030(transcript)|intact:EBI-744027(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:FQqhbuxItvCQ2iu5nydvHZaNog89606 rogid:cJ5eLH0TMyM6OtmS1sM3rhsrsIk9606 rigid:RvJdIJ/WW0O0g1PDXjEE4paz50A false tag:n-n ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9BXL7 intact:EBI-4399559 intact:EBI-7006141|intact:EBI-28969961|ensembl:ENSP00000380150|uniprotkb:Q2NKN7|intact:MINT-193901|uniprotkb:A4D1Z7|uniprotkb:Q548H3 dip:DIP-24261N psi-mi:car11_human(display_long)|uniprotkb:CARD11(gene name)|psi-mi:CARD11(display_short)|uniprotkb:CARMA1(gene name synonym)|uniprotkb:CARD-containing MAGUK protein 1(gene name synonym) psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kojo et al. (2009) pubmed:19815501|doi:10.1073/pnas.0904078106|imex:IM-14850 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15808333|imex:IM-14850-4|dip:DIP-104166E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000380150|refseq:NP_001311210.1|refseq:XP_011513888.1|ensembl:ENSG00000198286(gene)|ensembl:ENST00000396946(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032449"(CBM complex)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045121"(membrane raft)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR033538|interpro:IPR036034|interpro:IPR042141|mint:Q9BXL7|rcsb pdb:4JUP|rcsb pdb:4LWD|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|refseq:NP_115791.3|dip:DIP-41797N uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2 psi-mi:"MI:0465"(dip) comment:mint|comment:homomint|function:Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10 no-uniprot-update: full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/15 rogid:6Brt3NrkQt4m0X6OTPgixpH3E5w9606 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606 rigid:5MmeGt2jkFDkZTDnBjFV1RomFqk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BXL7 uniprotkb:O95999 intact:EBI-7006141|intact:EBI-28969961|ensembl:ENSP00000380150|uniprotkb:Q2NKN7|intact:MINT-193901|uniprotkb:A4D1Z7|uniprotkb:Q548H3 intact:EBI-958922|ensembl:ENSP00000498104|uniprotkb:Q5VUF1 psi-mi:car11_human(display_long)|uniprotkb:CARD11(gene name)|psi-mi:CARD11(display_short)|uniprotkb:CARMA1(gene name synonym)|uniprotkb:CARD-containing MAGUK protein 1(gene name synonym) psi-mi:bcl10_human(display_long)|uniprotkb:BCL10(gene name)|psi-mi:BCL10(display_short)|uniprotkb:CIPER(gene name synonym)|uniprotkb:CLAP(gene name synonym)|uniprotkb:Cellular homolog of vCARMEN(gene name synonym)|uniprotkb:Mammalian CARD-containing adapter molecule E10(gene name synonym)|uniprotkb:Cellular-E10(gene name synonym)|uniprotkb:CARD-like apoptotic protein(gene name synonym)|uniprotkb:B-cell CLL/lymphoma 10(gene name synonym)|uniprotkb:CED-3/ICH-1 prodomain homologous E10-like regulator(gene name synonym)|uniprotkb:CARD-containing molecule enhancing NF-kappa-B(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kojo et al. (2009) pubmed:19815501|doi:10.1073/pnas.0904078106|imex:IM-14850 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15808388|imex:IM-14850-7|dip:DIP-71166E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000380150|refseq:NP_001311210.1|refseq:XP_011513888.1|ensembl:ENSG00000198286(gene)|ensembl:ENST00000396946(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032449"(CBM complex)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045121"(membrane raft)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR033538|interpro:IPR036034|interpro:IPR042141|mint:Q9BXL7|rcsb pdb:4JUP|rcsb pdb:4LWD|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|refseq:NP_115791.3|dip:DIP-41797N ensembl:ENSG00000142867(gene)|ensembl:ENST00000648566(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001843"(neural tube closure)|go:"GO:0002020"(protease binding)|go:"GO:0002096"(polkadots)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032094"(response to food)|go:"GO:0032449"(CBM complex)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032761"(positive regulation of lymphotoxin A production)|go:"GO:0032765"(positive regulation of mast cell cytokine production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR033238|interpro:IPR042143|mint:O95999|rcsb pdb:2MB9|rcsb pdb:6BZE|rcsb pdb:6GK2|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|reactome:R-HSA-8866654|refseq:NP_003912.1|dip:DIP-29740N psi-mi:"MI:0465"(dip) comment:mint|comment:homomint|function:Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10 - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:6Brt3NrkQt4m0X6OTPgixpH3E5w9606 rogid:BUrlS8JdWGi4LWWgp0FfpILCeDY9606 rigid:a7d1fVXryd17Oghx91e5We/MJZw false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BXL7 uniprotkb:Q13191-1 intact:EBI-7006141|intact:EBI-28969961|ensembl:ENSP00000380150|uniprotkb:Q2NKN7|intact:MINT-193901|uniprotkb:A4D1Z7|uniprotkb:Q548H3 intact:EBI-15555129|ensembl:ENSP00000377598 psi-mi:car11_human(display_long)|uniprotkb:CARD11(gene name)|psi-mi:CARD11(display_short)|uniprotkb:CARMA1(gene name synonym)|uniprotkb:CARD-containing MAGUK protein 1(gene name synonym) psi-mi:q13191-1(display_long)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING finger protein 56(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:Nbla00127(orf name)|uniprotkb:CBLB(gene name)|psi-mi:CBLB(display_short)|uniprotkb:RNF56(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kojo et al. (2009) pubmed:19815501|doi:10.1073/pnas.0904078106|imex:IM-14850 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15808371|imex:IM-14850-6|dip:DIP-104165E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000380150|refseq:NP_001311210.1|refseq:XP_011513888.1|ensembl:ENSG00000198286(gene)|ensembl:ENST00000396946(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032449"(CBM complex)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045121"(membrane raft)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR033538|interpro:IPR036034|interpro:IPR042141|mint:Q9BXL7|rcsb pdb:4JUP|rcsb pdb:4LWD|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|refseq:NP_115791.3|dip:DIP-41797N ensembl:ENSG00000114423(gene)|ensembl:ENST00000394030(transcript)|intact:EBI-744027(isoform-parent) psi-mi:"MI:0465"(dip) comment:mint|comment:homomint|function:Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10 - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:6Brt3NrkQt4m0X6OTPgixpH3E5w9606 rogid:cJ5eLH0TMyM6OtmS1sM3rhsrsIk9606 rigid:UKEUae6fKI6dK47+YVVHhl3rcFM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BXL7 uniprotkb:Q13191-1 intact:EBI-7006141|intact:EBI-28969961|ensembl:ENSP00000380150|uniprotkb:Q2NKN7|intact:MINT-193901|uniprotkb:A4D1Z7|uniprotkb:Q548H3 intact:EBI-15555129|ensembl:ENSP00000377598 psi-mi:car11_human(display_long)|uniprotkb:CARD11(gene name)|psi-mi:CARD11(display_short)|uniprotkb:CARMA1(gene name synonym)|uniprotkb:CARD-containing MAGUK protein 1(gene name synonym) psi-mi:q13191-1(display_long)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING finger protein 56(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:Nbla00127(orf name)|uniprotkb:CBLB(gene name)|psi-mi:CBLB(display_short)|uniprotkb:RNF56(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kojo et al. (2009) pubmed:19815501|doi:10.1073/pnas.0904078106|imex:IM-14850 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15808350|imex:IM-14850-5|dip:DIP-104165E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000380150|refseq:NP_001311210.1|refseq:XP_011513888.1|ensembl:ENSG00000198286(gene)|ensembl:ENST00000396946(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032449"(CBM complex)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045121"(membrane raft)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR033538|interpro:IPR036034|interpro:IPR042141|mint:Q9BXL7|rcsb pdb:4JUP|rcsb pdb:4LWD|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|refseq:NP_115791.3|dip:DIP-41797N ensembl:ENSG00000114423(gene)|ensembl:ENST00000394030(transcript)|intact:EBI-744027(isoform-parent) psi-mi:"MI:0465"(dip) comment:mint|comment:homomint|function:Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10 - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:6Brt3NrkQt4m0X6OTPgixpH3E5w9606 rogid:cJ5eLH0TMyM6OtmS1sM3rhsrsIk9606 rigid:UKEUae6fKI6dK47+YVVHhl3rcFM false tag:n-n ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9BXL7 intact:EBI-4399559 intact:EBI-7006141|intact:EBI-28969961|ensembl:ENSP00000380150|uniprotkb:Q2NKN7|intact:MINT-193901|uniprotkb:A4D1Z7|uniprotkb:Q548H3 dip:DIP-24261N psi-mi:car11_human(display_long)|uniprotkb:CARD11(gene name)|psi-mi:CARD11(display_short)|uniprotkb:CARMA1(gene name synonym)|uniprotkb:CARD-containing MAGUK protein 1(gene name synonym) psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kojo et al. (2009) pubmed:19815501|doi:10.1073/pnas.0904078106|imex:IM-14850 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15808405|imex:IM-14850-8|dip:DIP-104166E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000380150|refseq:NP_001311210.1|refseq:XP_011513888.1|ensembl:ENSG00000198286(gene)|ensembl:ENST00000396946(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032449"(CBM complex)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045121"(membrane raft)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR033538|interpro:IPR036034|interpro:IPR042141|mint:Q9BXL7|rcsb pdb:4JUP|rcsb pdb:4LWD|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|refseq:NP_115791.3|dip:DIP-41797N uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2 psi-mi:"MI:0465"(dip) comment:mint|comment:homomint|function:Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10 no-uniprot-update: full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/15 rogid:6Brt3NrkQt4m0X6OTPgixpH3E5w9606 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606 rigid:5MmeGt2jkFDkZTDnBjFV1RomFqk false flag tag:n-n ha tag:0-0 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)