#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q01484	uniprotkb:Q14654	intact:EBI-941975|uniprotkb:Q01485|uniprotkb:Q08AC7|uniprotkb:Q08AC8|uniprotkb:Q7Z3L5|ensembl:ENSP00000349588	intact:EBI-2866553|uniprotkb:Q58EX3|uniprotkb:Q2M1H7|uniprotkb:B4DWI4|uniprotkb:E9PNK0|uniprotkb:Q8IW96|ensembl:ENSP00000345708|ensembl:ENSP00000434755	psi-mi:ank2_human(display_long)|uniprotkb:ANKB(gene name synonym)|uniprotkb:ANK2(gene name)|psi-mi:ANK2(display_short)|uniprotkb:Brain ankyrin(gene name synonym)|uniprotkb:Ankyrin-B(gene name synonym)|uniprotkb:Non-erythroid ankyrin(gene name synonym)	psi-mi:kcj11_human(display_long)|uniprotkb:KCNJ11(gene name)|psi-mi:KCNJ11(display_short)|uniprotkb:IKATP(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kline et al. (2009)	pubmed:19805355|doi:10.1073/pnas.0907138106|imex:IM-15254	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15807469|imex:IM-15254-2|dip:DIP-185776E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001120965.1|refseq:NP_001139.3|refseq:NP_066187.2|dip:DIP-37425N|ensembl:ENSG00000145362(gene)|ensembl:ENST00000357077(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003283"(atrial septum development)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0031430"(M band)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031672"(A band)|go:"GO:0033292"(T-tubule organization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0036371"(protein localization to T-tubule)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0043034"(costamere)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051597"(response to methylmercury)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086066"(atrial cardiac muscle cell to AV node cell communication)|go:"GO:0086070"(SA node cell to atrial cardiac muscle cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901021"(positive regulation of calcium ion transmembrane transporter activity)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR040745|mint:Q01484|rcsb pdb:4D8O|rcsb pdb:4RLV|rcsb pdb:4RLY|rcsb pdb:5Y4D|rcsb pdb:5Y4E|rcsb pdb:5Y4F|rcsb pdb:5YIR|rcsb pdb:5YIS|rcsb pdb:6KZJ|rcsb pdb:6M3Q|reactome:R-HSA-445095|reactome:R-HSA-6807878	refseq:NP_001159762.1|dip:DIP-58643N|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|rcsb pdb:6C3O|rcsb pdb:6C3P|reactome:R-HSA-1296025|reactome:R-HSA-382556|reactome:R-HSA-422356|reactome:R-HSA-5578775|reactome:R-HSA-5678420|reactome:R-HSA-5683177|ensembl:ENST00000339994(transcript)|ensembl:ENST00000528731(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0014704"(intercalated disc)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033198"(response to ATP)|go:"GO:0033574"(response to testosterone)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050877"(nervous system process)|go:"GO:0070852"(cell body fiber)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098662"(inorganic cation transmembrane transport)|ensembl:ENSG00000187486(gene)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:wHoFDw3CIP2xOUZj9WzEMGm/z8k9606	rogid:EgyckzNz0VCMnwzK/U9vz8J2auk9606	rigid:yZTEkf75uV7yET76S7Pn09fE3BM	false	35s radiolabel:?-?|binding-associated region:1-861	binding-associated region:313-325|biotin tag:n-n|mutation decreasing interaction:322-322	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P70673	uniprotkb:P97582	intact:EBI-9560239|uniprotkb:Q62906|uniprotkb:Q9JM48|ensembl:ENSRNOP00000028685	intact:EBI-2255943	psi-mi:kcj11_rat(display_long)|uniprotkb:Kcnj11(gene name)|psi-mi:Kcnj11(display_short)|uniprotkb:BIR(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym)	psi-mi:p97582_rat(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kline et al. (2009)	pubmed:19805355|doi:10.1073/pnas.0907138106|imex:IM-15254	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15807452|imex:IM-15254-1|dip:DIP-185775E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:69247|refseq:NP_112648.2|dip:DIP-58641N|ensembl:ENSRNOG00000021128(gene)|ensembl:ENSRNOT00000028685(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0014704"(intercalated disc)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033198"(response to ATP)|go:"GO:0033574"(response to testosterone)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050877"(nervous system process)|go:"GO:0070852"(cell body fiber)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|rcsb pdb:5TWV|rcsb pdb:6BAA|rcsb pdb:6PZ9|rcsb pdb:6PZA|reactome:R-RNO-1296025|reactome:R-RNO-382556|reactome:R-RNO-422356|reactome:R-RNO-5578775	dip:DIP-53073N|go:"GO:0005102"(signaling receptor binding)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/06	2017/08/10	rogid:5ZUdreoVKRhgvPw3N3zwAId+2eg10116	rogid:hwna4ZW4rv+0mq1jcteYs1nEFe010116	rigid:HVbVNsnvFRQNWumE87yr4hUNp5k	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12955	uniprotkb:Q14524	intact:EBI-2691178|uniprotkb:Q5VXD5|intact:EBI-7224084|intact:MINT-1182900|uniprotkb:Q13484|uniprotkb:B4DIL1|uniprotkb:E9PE32|uniprotkb:Q5CZH9|uniprotkb:Q7Z3G4|uniprotkb:B1AQT2|uniprotkb:Q9H0P5|ensembl:ENSP00000280772	intact:EBI-726858|uniprotkb:Q59H93|uniprotkb:E9PEF3|uniprotkb:A5H1P8|uniprotkb:A6N922|uniprotkb:A6N923|uniprotkb:B2RTU0|uniprotkb:Q75RX9|uniprotkb:Q75RY0|uniprotkb:Q86UR3|uniprotkb:Q8IZC9|uniprotkb:Q96J69|uniprotkb:E9PEK2|uniprotkb:E9PFW7|uniprotkb:E7ET19|intact:EBI-28981518|ensembl:ENSP00000328968	psi-mi:ank3_human(display_long)|uniprotkb:Ankyrin-G(gene name synonym)|uniprotkb:ANK3(gene name)|psi-mi:ANK3(display_short)	psi-mi:scn5a_human(display_long)|uniprotkb:Sodium channel protein type V subunit alpha(gene name synonym)|uniprotkb:Voltage-gated sodium channel subunit alpha Nav1.5(gene name synonym)|uniprotkb:Sodium channel protein cardiac muscle subunit alpha(gene name synonym)|uniprotkb:SCN5A(gene name)|psi-mi:SCN5A(display_short)|uniprotkb:hH1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kline et al. (2009)	pubmed:19805355|doi:10.1073/pnas.0907138106|imex:IM-15254	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15807622|imex:IM-15254-9|dip:DIP-185777E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000280772|ensembl:ENST00000355288|ensembl:ENSP00000347436|ensembl:ENST00000373827|ensembl:ENSP00000362933|ensembl:ENST00000503366|ensembl:ENSP00000425236|refseq:NP_066267.2|refseq:NP_001191332.1|refseq:NP_001191333.1|refseq:NP_001140.2|ensembl:ENSG00000151150(gene)|ensembl:ENST00000280772(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010650"(positive regulation of cell communication by electrical coupling)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014704"(intercalated disc)|go:"GO:0014731"(spectrin-associated cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030425"(dendrite)|go:"GO:0030507"(spectrin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033268"(node of Ranvier)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042383"(sarcolemma)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043034"(costamere)|go:"GO:0043194"(axon initial segment)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072660"(maintenance of protein location in plasma membrane)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0099612"(protein localization to axon)|go:"GO:1900827"(positive regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR037971|interpro:IPR040745|rcsb pdb:4O6X|reactome:R-HSA-445095|reactome:R-HSA-6807878|go:"GO:0005783"(endoplasmic reticulum)|dip:DIP-49017N	refseq:NP_000326.2|refseq:NP_001092874.1|refseq:NP_001092875.1|refseq:NP_001153632.1|refseq:NP_001153633.1|refseq:NP_932173.1|ensembl:ENSP00000328968|ensembl:ENST00000423572|ensembl:ENSP00000398266|ensembl:ENSG00000183873(gene)|ensembl:ENST00000333535(transcript)|go:"GO:0001518"(voltage-gated sodium channel complex)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003231"(cardiac ventricle development)|go:"GO:0003360"(brainstem development)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009986"(cell surface)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0021549"(cerebellum development)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042383"(sarcolemma)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0060371"(regulation of atrial cardiac muscle cell membrane depolarization)|go:"GO:0060372"(regulation of atrial cardiac muscle cell membrane repolarization)|go:"GO:0060373"(regulation of ventricular cardiac muscle cell membrane depolarization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086006"(voltage-gated sodium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086016"(AV node cell action potential)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086047"(membrane depolarization during Purkinje myocyte cell action potential)|go:"GO:0086048"(membrane depolarization during bundle of His cell action potential)|go:"GO:0086060"(voltage-gated sodium channel activity involved in AV node cell action potential)|go:"GO:0086061"(voltage-gated sodium channel activity involved in bundle of His cell action potential)|go:"GO:0086062"(voltage-gated sodium channel activity involved in Purkinje myocyte action potential)|go:"GO:0086063"(voltage-gated sodium channel activity involved in SA node cell action potential)|go:"GO:0086067"(AV node cell to bundle of His cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:1902305"(regulation of sodium ion transmembrane transport)|interpro:IPR001696(Na+ channel)|interpro:IPR005821(Ion transport)|interpro:IPR008053(Na+ channel 5)|interpro:IPR010526(Sodium ion transport-associated)|interpro:IPR024583|interpro:IPR027359|interpro:IPR043203|interpro:IPR044564|rcsb pdb:2KBI|rcsb pdb:2L53|go:"GO:0086043"(bundle of His cell action potential)|rcsb pdb:4DCK|rcsb pdb:4DJC|rcsb pdb:4JQ0|rcsb pdb:4OVN|rcsb pdb:5DBR|rcsb pdb:6LQA|rcsb pdb:6MUD|rcsb pdb:7DTC|rcsb pdb:7L83|reactome:R-HSA-445095|reactome:R-HSA-5576892|dip:DIP-38416N|dip:DIP-46144N	psi-mi:"MI:0465"(dip)	-	caution:This sequence has been withdrawn from Uniprot.	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:k03Sz+VxForOlnJt8P9i8KAFzss9606	rogid:WJ23sEfaxGTHEngY52K92JChA6U9606	rigid:lMsJ8blmZ0E0jM/b3j9PSwCqlBU	false	binding-associated region:1-886|glutathione s tranferase tag:n-n	mutation decreasing interaction:1053-1053|35s radiolabel:?-?|binding-associated region:1047-1055	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q01484	uniprotkb:Q14654	intact:EBI-941975|uniprotkb:Q01485|uniprotkb:Q08AC7|uniprotkb:Q08AC8|uniprotkb:Q7Z3L5|ensembl:ENSP00000349588	intact:EBI-2866553|uniprotkb:Q58EX3|uniprotkb:Q2M1H7|uniprotkb:B4DWI4|uniprotkb:E9PNK0|uniprotkb:Q8IW96|ensembl:ENSP00000345708|ensembl:ENSP00000434755	psi-mi:ank2_human(display_long)|uniprotkb:ANKB(gene name synonym)|uniprotkb:ANK2(gene name)|psi-mi:ANK2(display_short)|uniprotkb:Brain ankyrin(gene name synonym)|uniprotkb:Ankyrin-B(gene name synonym)|uniprotkb:Non-erythroid ankyrin(gene name synonym)	psi-mi:kcj11_human(display_long)|uniprotkb:KCNJ11(gene name)|psi-mi:KCNJ11(display_short)|uniprotkb:IKATP(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kline et al. (2009)	pubmed:19805355|doi:10.1073/pnas.0907138106|imex:IM-15254	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15807565|imex:IM-15254-6|dip:DIP-185776E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001120965.1|refseq:NP_001139.3|refseq:NP_066187.2|dip:DIP-37425N|ensembl:ENSG00000145362(gene)|ensembl:ENST00000357077(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003283"(atrial septum development)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0031430"(M band)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031672"(A band)|go:"GO:0033292"(T-tubule organization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0036371"(protein localization to T-tubule)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0043034"(costamere)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051597"(response to methylmercury)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086066"(atrial cardiac muscle cell to AV node cell communication)|go:"GO:0086070"(SA node cell to atrial cardiac muscle cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901021"(positive regulation of calcium ion transmembrane transporter activity)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR040745|mint:Q01484|rcsb pdb:4D8O|rcsb pdb:4RLV|rcsb pdb:4RLY|rcsb pdb:5Y4D|rcsb pdb:5Y4E|rcsb pdb:5Y4F|rcsb pdb:5YIR|rcsb pdb:5YIS|rcsb pdb:6KZJ|rcsb pdb:6M3Q|reactome:R-HSA-445095|reactome:R-HSA-6807878	refseq:NP_001159762.1|dip:DIP-58643N|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|rcsb pdb:6C3O|rcsb pdb:6C3P|reactome:R-HSA-1296025|reactome:R-HSA-382556|reactome:R-HSA-422356|reactome:R-HSA-5578775|reactome:R-HSA-5678420|reactome:R-HSA-5683177|ensembl:ENST00000339994(transcript)|ensembl:ENST00000528731(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0014704"(intercalated disc)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033198"(response to ATP)|go:"GO:0033574"(response to testosterone)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050877"(nervous system process)|go:"GO:0070852"(cell body fiber)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098662"(inorganic cation transmembrane transport)|ensembl:ENSG00000187486(gene)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:wHoFDw3CIP2xOUZj9WzEMGm/z8k9606	rogid:EgyckzNz0VCMnwzK/U9vz8J2auk9606	rigid:yZTEkf75uV7yET76S7Pn09fE3BM	false	-	mutation disrupting interaction:322-322	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q61743	uniprotkb:Q8C8R3	intact:EBI-8603527|ensembl:ENSMUSP00000147439|intact:MINT-2982880|uniprotkb:Q9QX21	intact:EBI-774322|intact:EBI-2133064|uniprotkb:Q6PCN2|uniprotkb:Q3TM62|uniprotkb:Q3V2X0|uniprotkb:Q80ZZ7|uniprotkb:Q8BNC1|uniprotkb:Q8C445|uniprotkb:Q8CCV0|intact:EBI-2255612|intact:EBI-8314005|intact:MINT-4115219	psi-mi:kcj11_mouse(display_long)|uniprotkb:Kcnj11(gene name)|psi-mi:Kcnj11(display_short)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym)	psi-mi:ank2_mouse(display_long)|uniprotkb:Brain ankyrin(gene name synonym)|uniprotkb:AnkB(gene name synonym)|uniprotkb:Ank2(gene name)|psi-mi:Ank2(display_short)|uniprotkb:Ankyrin-B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kline et al. (2009)	pubmed:19805355|doi:10.1073/pnas.0907138106|imex:IM-15254	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15807585|imex:IM-15254-7|dip:DIP-185781E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000096146(gene)|ensembl:ENSMUST00000211674(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0014704"(intercalated disc)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033198"(response to ATP)|go:"GO:0033574"(response to testosterone)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050877"(nervous system process)|go:"GO:0070852"(cell body fiber)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|mint:Q61743|rcsb pdb:5WUA|rcsb pdb:5YKE|rcsb pdb:5YKF|rcsb pdb:5YKG|rcsb pdb:5YW8|rcsb pdb:5YW9|rcsb pdb:5YWA|rcsb pdb:5YWB|rcsb pdb:5YWC|rcsb pdb:6JB1|reactome:R-MMU-1296025|reactome:R-MMU-382556|reactome:R-MMU-422356|reactome:R-MMU-5578775|refseq:NP_034732.1|dip:DIP-42790N	refseq:NP_001029340.1|refseq:NP_848770.2|dip:DIP-58645N|mint:Q8C8R3|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0008104"(protein localization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0015031"(protein transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031430"(M band)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031672"(A band)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0036371"(protein localization to T-tubule)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086066"(atrial cardiac muscle cell to AV node cell communication)|go:"GO:0086070"(SA node cell to atrial cardiac muscle cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901021"(positive regulation of calcium ion transmembrane transporter activity)|go:"GO:2001257"(regulation of cation channel activity)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR040745	psi-mi:"MI:0465"(dip)	comment:mint|function:This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:YH8BUXfxLJ46b4AxxBmt1RmrNtM10090	rogid:SkB13oxZVcKuMnI8r5ItFIq2pXQ10090	rigid:5dv5XXXbh9/vhPmP36t7JZKzwqo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q01484	uniprotkb:Q14654	intact:EBI-941975|uniprotkb:Q01485|uniprotkb:Q08AC7|uniprotkb:Q08AC8|uniprotkb:Q7Z3L5|ensembl:ENSP00000349588	intact:EBI-2866553|uniprotkb:Q58EX3|uniprotkb:Q2M1H7|uniprotkb:B4DWI4|uniprotkb:E9PNK0|uniprotkb:Q8IW96|ensembl:ENSP00000345708|ensembl:ENSP00000434755	psi-mi:ank2_human(display_long)|uniprotkb:ANKB(gene name synonym)|uniprotkb:ANK2(gene name)|psi-mi:ANK2(display_short)|uniprotkb:Brain ankyrin(gene name synonym)|uniprotkb:Ankyrin-B(gene name synonym)|uniprotkb:Non-erythroid ankyrin(gene name synonym)	psi-mi:kcj11_human(display_long)|uniprotkb:KCNJ11(gene name)|psi-mi:KCNJ11(display_short)|uniprotkb:IKATP(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kline et al. (2009)	pubmed:19805355|doi:10.1073/pnas.0907138106|imex:IM-15254	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15807602|imex:IM-15254-8|dip:DIP-185776E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001120965.1|refseq:NP_001139.3|refseq:NP_066187.2|dip:DIP-37425N|ensembl:ENSG00000145362(gene)|ensembl:ENST00000357077(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003283"(atrial septum development)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0031430"(M band)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031672"(A band)|go:"GO:0033292"(T-tubule organization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0036371"(protein localization to T-tubule)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0043034"(costamere)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051597"(response to methylmercury)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086066"(atrial cardiac muscle cell to AV node cell communication)|go:"GO:0086070"(SA node cell to atrial cardiac muscle cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901021"(positive regulation of calcium ion transmembrane transporter activity)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR040745|mint:Q01484|rcsb pdb:4D8O|rcsb pdb:4RLV|rcsb pdb:4RLY|rcsb pdb:5Y4D|rcsb pdb:5Y4E|rcsb pdb:5Y4F|rcsb pdb:5YIR|rcsb pdb:5YIS|rcsb pdb:6KZJ|rcsb pdb:6M3Q|reactome:R-HSA-445095|reactome:R-HSA-6807878	refseq:NP_001159762.1|dip:DIP-58643N|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|rcsb pdb:6C3O|rcsb pdb:6C3P|reactome:R-HSA-1296025|reactome:R-HSA-382556|reactome:R-HSA-422356|reactome:R-HSA-5578775|reactome:R-HSA-5678420|reactome:R-HSA-5683177|ensembl:ENST00000339994(transcript)|ensembl:ENST00000528731(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0014704"(intercalated disc)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033198"(response to ATP)|go:"GO:0033574"(response to testosterone)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050877"(nervous system process)|go:"GO:0070852"(cell body fiber)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098662"(inorganic cation transmembrane transport)|ensembl:ENSG00000187486(gene)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:wHoFDw3CIP2xOUZj9WzEMGm/z8k9606	rogid:EgyckzNz0VCMnwzK/U9vz8J2auk9606	rigid:yZTEkf75uV7yET76S7Pn09fE3BM	false	-	mutation disrupting interaction:322-322	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:B2RUS7	uniprotkb:Q8C8R3	intact:EBI-10953778|ensembl:ENSMUSP00000033123	intact:EBI-774322|intact:EBI-2133064|uniprotkb:Q6PCN2|uniprotkb:Q3TM62|uniprotkb:Q3V2X0|uniprotkb:Q80ZZ7|uniprotkb:Q8BNC1|uniprotkb:Q8C445|uniprotkb:Q8CCV0|intact:EBI-2255612|intact:EBI-8314005|intact:MINT-4115219	psi-mi:b2rus7_mouse(display_long)|uniprotkb:Abcc8(gene name)|psi-mi:Abcc8(display_short)	psi-mi:ank2_mouse(display_long)|uniprotkb:Brain ankyrin(gene name synonym)|uniprotkb:AnkB(gene name synonym)|uniprotkb:Ank2(gene name)|psi-mi:Ank2(display_short)|uniprotkb:Ankyrin-B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kline et al. (2009)	pubmed:19805355|doi:10.1073/pnas.0907138106|imex:IM-15254	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15807531|imex:IM-15254-4|dip:DIP-185782E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035640.2|ensembl:ENSMUSG00000040136(gene)|ensembl:ENSMUST00000033123(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0007565"(female pregnancy)|go:"GO:0007613"(memory)|go:"GO:0008281"(sulfonylurea receptor activity)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0008542"(visual learning)|go:"GO:0009268"(response to pH)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0055085"(transmembrane transport)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061855"(negative regulation of neuroblast migration)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:1900721"(positive regulation of uterine smooth muscle relaxation)|go:"GO:1903818"(positive regulation of voltage-gated potassium channel activity)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|interpro:IPR000388(Sulphonylurea receptor, N-terminus)|interpro:IPR000844(Sulphonylurea receptor, type 1, N-terminus)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|reactome:R-MMU-1296025|reactome:R-MMU-422356|dip:DIP-58644N	refseq:NP_001029340.1|refseq:NP_848770.2|dip:DIP-58645N|mint:Q8C8R3|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0008104"(protein localization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0015031"(protein transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031430"(M band)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031672"(A band)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0036371"(protein localization to T-tubule)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086066"(atrial cardiac muscle cell to AV node cell communication)|go:"GO:0086070"(SA node cell to atrial cardiac muscle cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901021"(positive regulation of calcium ion transmembrane transporter activity)|go:"GO:2001257"(regulation of cation channel activity)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR040745	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:kv1B9xrqTuQwecNgGeHotZe6V4o10090	rogid:SkB13oxZVcKuMnI8r5ItFIq2pXQ10090	rigid:WDQfVuCX/M8367VPASIDSLwr/Os	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q01484	uniprotkb:Q14654	intact:EBI-941975|uniprotkb:Q01485|uniprotkb:Q08AC7|uniprotkb:Q08AC8|uniprotkb:Q7Z3L5|ensembl:ENSP00000349588	intact:EBI-2866553|uniprotkb:Q58EX3|uniprotkb:Q2M1H7|uniprotkb:B4DWI4|uniprotkb:E9PNK0|uniprotkb:Q8IW96|ensembl:ENSP00000345708|ensembl:ENSP00000434755	psi-mi:ank2_human(display_long)|uniprotkb:ANKB(gene name synonym)|uniprotkb:ANK2(gene name)|psi-mi:ANK2(display_short)|uniprotkb:Brain ankyrin(gene name synonym)|uniprotkb:Ankyrin-B(gene name synonym)|uniprotkb:Non-erythroid ankyrin(gene name synonym)	psi-mi:kcj11_human(display_long)|uniprotkb:KCNJ11(gene name)|psi-mi:KCNJ11(display_short)|uniprotkb:IKATP(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kline et al. (2009)	pubmed:19805355|doi:10.1073/pnas.0907138106|imex:IM-15254	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15807497|imex:IM-15254-3|dip:DIP-185776E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001120965.1|refseq:NP_001139.3|refseq:NP_066187.2|dip:DIP-37425N|ensembl:ENSG00000145362(gene)|ensembl:ENST00000357077(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003283"(atrial septum development)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0031430"(M band)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031672"(A band)|go:"GO:0033292"(T-tubule organization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0036371"(protein localization to T-tubule)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0043034"(costamere)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051597"(response to methylmercury)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086066"(atrial cardiac muscle cell to AV node cell communication)|go:"GO:0086070"(SA node cell to atrial cardiac muscle cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901021"(positive regulation of calcium ion transmembrane transporter activity)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR040745|mint:Q01484|rcsb pdb:4D8O|rcsb pdb:4RLV|rcsb pdb:4RLY|rcsb pdb:5Y4D|rcsb pdb:5Y4E|rcsb pdb:5Y4F|rcsb pdb:5YIR|rcsb pdb:5YIS|rcsb pdb:6KZJ|rcsb pdb:6M3Q|reactome:R-HSA-445095|reactome:R-HSA-6807878	refseq:NP_001159762.1|dip:DIP-58643N|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|rcsb pdb:6C3O|rcsb pdb:6C3P|reactome:R-HSA-1296025|reactome:R-HSA-382556|reactome:R-HSA-422356|reactome:R-HSA-5578775|reactome:R-HSA-5678420|reactome:R-HSA-5683177|ensembl:ENST00000339994(transcript)|ensembl:ENST00000528731(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0014704"(intercalated disc)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033198"(response to ATP)|go:"GO:0033574"(response to testosterone)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050877"(nervous system process)|go:"GO:0070852"(cell body fiber)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098662"(inorganic cation transmembrane transport)|ensembl:ENSG00000187486(gene)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:wHoFDw3CIP2xOUZj9WzEMGm/z8k9606	rogid:EgyckzNz0VCMnwzK/U9vz8J2auk9606	rigid:yZTEkf75uV7yET76S7Pn09fE3BM	false	sufficient binding region:1-861|glutathione s tranferase tag:n-n	35s radiolabel:?-?|sufficient binding region:1-330|mutation disrupting interaction:321-321|mutation disrupting interaction:322-322|mutation disrupting interaction:323-323	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q61743	uniprotkb:B2RUS7	intact:EBI-8603527|ensembl:ENSMUSP00000147439|intact:MINT-2982880|uniprotkb:Q9QX21	intact:EBI-10953778|ensembl:ENSMUSP00000033123	psi-mi:kcj11_mouse(display_long)|uniprotkb:Kcnj11(gene name)|psi-mi:Kcnj11(display_short)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym)	psi-mi:b2rus7_mouse(display_long)|uniprotkb:Abcc8(gene name)|psi-mi:Abcc8(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kline et al. (2009)	pubmed:19805355|doi:10.1073/pnas.0907138106|imex:IM-15254	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15807548|imex:IM-15254-5|dip:DIP-185780E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000096146(gene)|ensembl:ENSMUST00000211674(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0014704"(intercalated disc)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033198"(response to ATP)|go:"GO:0033574"(response to testosterone)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050877"(nervous system process)|go:"GO:0070852"(cell body fiber)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|mint:Q61743|rcsb pdb:5WUA|rcsb pdb:5YKE|rcsb pdb:5YKF|rcsb pdb:5YKG|rcsb pdb:5YW8|rcsb pdb:5YW9|rcsb pdb:5YWA|rcsb pdb:5YWB|rcsb pdb:5YWC|rcsb pdb:6JB1|reactome:R-MMU-1296025|reactome:R-MMU-382556|reactome:R-MMU-422356|reactome:R-MMU-5578775|refseq:NP_034732.1|dip:DIP-42790N	refseq:NP_035640.2|ensembl:ENSMUSG00000040136(gene)|ensembl:ENSMUST00000033123(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0007565"(female pregnancy)|go:"GO:0007613"(memory)|go:"GO:0008281"(sulfonylurea receptor activity)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0008542"(visual learning)|go:"GO:0009268"(response to pH)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0055085"(transmembrane transport)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061855"(negative regulation of neuroblast migration)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:1900721"(positive regulation of uterine smooth muscle relaxation)|go:"GO:1903818"(positive regulation of voltage-gated potassium channel activity)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|interpro:IPR000388(Sulphonylurea receptor, N-terminus)|interpro:IPR000844(Sulphonylurea receptor, type 1, N-terminus)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|reactome:R-MMU-1296025|reactome:R-MMU-422356|dip:DIP-58644N	psi-mi:"MI:0465"(dip)	comment:mint|function:This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:YH8BUXfxLJ46b4AxxBmt1RmrNtM10090	rogid:kv1B9xrqTuQwecNgGeHotZe6V4o10090	rigid:vtza7M4vj7IjMmsE+BezBKcn02o	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14654	uniprotkb:Q01484	intact:EBI-2866553|uniprotkb:Q58EX3|uniprotkb:Q2M1H7|uniprotkb:B4DWI4|uniprotkb:E9PNK0|uniprotkb:Q8IW96|ensembl:ENSP00000345708|ensembl:ENSP00000434755	intact:EBI-941975|uniprotkb:Q01485|uniprotkb:Q08AC7|uniprotkb:Q08AC8|uniprotkb:Q7Z3L5|ensembl:ENSP00000349588	psi-mi:kcj11_human(display_long)|uniprotkb:KCNJ11(gene name)|psi-mi:KCNJ11(display_short)|uniprotkb:IKATP(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym)	psi-mi:ank2_human(display_long)|uniprotkb:ANKB(gene name synonym)|uniprotkb:ANK2(gene name)|psi-mi:ANK2(display_short)|uniprotkb:Brain ankyrin(gene name synonym)|uniprotkb:Ankyrin-B(gene name synonym)|uniprotkb:Non-erythroid ankyrin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kline et al. (2009)	pubmed:19805355|doi:10.1073/pnas.0907138106|imex:IM-15254	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15807698|imex:IM-15254-12|dip:DIP-185778E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001159762.1|dip:DIP-58643N|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|rcsb pdb:6C3O|rcsb pdb:6C3P|reactome:R-HSA-1296025|reactome:R-HSA-382556|reactome:R-HSA-422356|reactome:R-HSA-5578775|reactome:R-HSA-5678420|reactome:R-HSA-5683177|ensembl:ENST00000339994(transcript)|ensembl:ENST00000528731(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0014704"(intercalated disc)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033198"(response to ATP)|go:"GO:0033574"(response to testosterone)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050877"(nervous system process)|go:"GO:0070852"(cell body fiber)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098662"(inorganic cation transmembrane transport)|ensembl:ENSG00000187486(gene)	refseq:NP_001120965.1|refseq:NP_001139.3|refseq:NP_066187.2|dip:DIP-37425N|ensembl:ENSG00000145362(gene)|ensembl:ENST00000357077(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003283"(atrial septum development)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0031430"(M band)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031672"(A band)|go:"GO:0033292"(T-tubule organization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0036371"(protein localization to T-tubule)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0043034"(costamere)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051597"(response to methylmercury)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086066"(atrial cardiac muscle cell to AV node cell communication)|go:"GO:0086070"(SA node cell to atrial cardiac muscle cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901021"(positive regulation of calcium ion transmembrane transporter activity)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR040745|mint:Q01484|rcsb pdb:4D8O|rcsb pdb:4RLV|rcsb pdb:4RLY|rcsb pdb:5Y4D|rcsb pdb:5Y4E|rcsb pdb:5Y4F|rcsb pdb:5YIR|rcsb pdb:5YIS|rcsb pdb:6KZJ|rcsb pdb:6M3Q|reactome:R-HSA-445095|reactome:R-HSA-6807878	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:EgyckzNz0VCMnwzK/U9vz8J2auk9606	rogid:wHoFDw3CIP2xOUZj9WzEMGm/z8k9606	rigid:INJcSqwnxFrp/49nf7dI9RDv1uU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14654	uniprotkb:Q09428-1	intact:EBI-2866553|uniprotkb:Q58EX3|uniprotkb:Q2M1H7|uniprotkb:B4DWI4|uniprotkb:E9PNK0|uniprotkb:Q8IW96|ensembl:ENSP00000345708|ensembl:ENSP00000434755	intact:EBI-15807650|ensembl:ENSP00000374467	psi-mi:kcj11_human(display_long)|uniprotkb:KCNJ11(gene name)|psi-mi:KCNJ11(display_short)|uniprotkb:IKATP(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym)	psi-mi:q09428-1(display_long)|uniprotkb:ABCC8(gene name)|psi-mi:ABCC8(display_short)|uniprotkb:HRINS(gene name synonym)|uniprotkb:SUR(gene name synonym)|uniprotkb:SUR1(gene name synonym)|uniprotkb:Sulfonylurea receptor 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kline et al. (2009)	pubmed:19805355|doi:10.1073/pnas.0907138106|imex:IM-15254	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15807698|imex:IM-15254-12|dip:DIP-185778E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001159762.1|dip:DIP-58643N|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|rcsb pdb:6C3O|rcsb pdb:6C3P|reactome:R-HSA-1296025|reactome:R-HSA-382556|reactome:R-HSA-422356|reactome:R-HSA-5578775|reactome:R-HSA-5678420|reactome:R-HSA-5683177|ensembl:ENST00000339994(transcript)|ensembl:ENST00000528731(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0014704"(intercalated disc)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033198"(response to ATP)|go:"GO:0033574"(response to testosterone)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050877"(nervous system process)|go:"GO:0070852"(cell body fiber)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098662"(inorganic cation transmembrane transport)|ensembl:ENSG00000187486(gene)	intact:EBI-9008940(isoform-parent)|ensembl:ENSG00000006071(gene)|ensembl:ENST00000389817(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:EgyckzNz0VCMnwzK/U9vz8J2auk9606	rogid:IZRAMEjIYb2g9tyhdMfSRSNynb09606	rigid:INJcSqwnxFrp/49nf7dI9RDv1uU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q01484	uniprotkb:Q14654	intact:EBI-941975|uniprotkb:Q01485|uniprotkb:Q08AC7|uniprotkb:Q08AC8|uniprotkb:Q7Z3L5|ensembl:ENSP00000349588	intact:EBI-2866553|uniprotkb:Q58EX3|uniprotkb:Q2M1H7|uniprotkb:B4DWI4|uniprotkb:E9PNK0|uniprotkb:Q8IW96|ensembl:ENSP00000345708|ensembl:ENSP00000434755	psi-mi:ank2_human(display_long)|uniprotkb:ANKB(gene name synonym)|uniprotkb:ANK2(gene name)|psi-mi:ANK2(display_short)|uniprotkb:Brain ankyrin(gene name synonym)|uniprotkb:Ankyrin-B(gene name synonym)|uniprotkb:Non-erythroid ankyrin(gene name synonym)	psi-mi:kcj11_human(display_long)|uniprotkb:KCNJ11(gene name)|psi-mi:KCNJ11(display_short)|uniprotkb:IKATP(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kline et al. (2009)	pubmed:19805355|doi:10.1073/pnas.0907138106|imex:IM-15254	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15807677|imex:IM-15254-11|dip:DIP-185778E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001120965.1|refseq:NP_001139.3|refseq:NP_066187.2|dip:DIP-37425N|ensembl:ENSG00000145362(gene)|ensembl:ENST00000357077(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003283"(atrial septum development)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0031430"(M band)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031672"(A band)|go:"GO:0033292"(T-tubule organization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0036371"(protein localization to T-tubule)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0043034"(costamere)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051597"(response to methylmercury)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086066"(atrial cardiac muscle cell to AV node cell communication)|go:"GO:0086070"(SA node cell to atrial cardiac muscle cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901021"(positive regulation of calcium ion transmembrane transporter activity)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR040745|mint:Q01484|rcsb pdb:4D8O|rcsb pdb:4RLV|rcsb pdb:4RLY|rcsb pdb:5Y4D|rcsb pdb:5Y4E|rcsb pdb:5Y4F|rcsb pdb:5YIR|rcsb pdb:5YIS|rcsb pdb:6KZJ|rcsb pdb:6M3Q|reactome:R-HSA-445095|reactome:R-HSA-6807878	refseq:NP_001159762.1|dip:DIP-58643N|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|rcsb pdb:6C3O|rcsb pdb:6C3P|reactome:R-HSA-1296025|reactome:R-HSA-382556|reactome:R-HSA-422356|reactome:R-HSA-5578775|reactome:R-HSA-5678420|reactome:R-HSA-5683177|ensembl:ENST00000339994(transcript)|ensembl:ENST00000528731(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0014704"(intercalated disc)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033198"(response to ATP)|go:"GO:0033574"(response to testosterone)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050877"(nervous system process)|go:"GO:0070852"(cell body fiber)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098662"(inorganic cation transmembrane transport)|ensembl:ENSG00000187486(gene)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:wHoFDw3CIP2xOUZj9WzEMGm/z8k9606	rogid:EgyckzNz0VCMnwzK/U9vz8J2auk9606	rigid:INJcSqwnxFrp/49nf7dI9RDv1uU	false	-	mutation disrupting interaction:322-322	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q01484	uniprotkb:Q09428-1	intact:EBI-941975|uniprotkb:Q01485|uniprotkb:Q08AC7|uniprotkb:Q08AC8|uniprotkb:Q7Z3L5|ensembl:ENSP00000349588	intact:EBI-15807650|ensembl:ENSP00000374467	psi-mi:ank2_human(display_long)|uniprotkb:ANKB(gene name synonym)|uniprotkb:ANK2(gene name)|psi-mi:ANK2(display_short)|uniprotkb:Brain ankyrin(gene name synonym)|uniprotkb:Ankyrin-B(gene name synonym)|uniprotkb:Non-erythroid ankyrin(gene name synonym)	psi-mi:q09428-1(display_long)|uniprotkb:ABCC8(gene name)|psi-mi:ABCC8(display_short)|uniprotkb:HRINS(gene name synonym)|uniprotkb:SUR(gene name synonym)|uniprotkb:SUR1(gene name synonym)|uniprotkb:Sulfonylurea receptor 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kline et al. (2009)	pubmed:19805355|doi:10.1073/pnas.0907138106|imex:IM-15254	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15807677|imex:IM-15254-11|dip:DIP-185778E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001120965.1|refseq:NP_001139.3|refseq:NP_066187.2|dip:DIP-37425N|ensembl:ENSG00000145362(gene)|ensembl:ENST00000357077(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003283"(atrial septum development)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0031430"(M band)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031672"(A band)|go:"GO:0033292"(T-tubule organization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0036371"(protein localization to T-tubule)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0043034"(costamere)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051597"(response to methylmercury)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086066"(atrial cardiac muscle cell to AV node cell communication)|go:"GO:0086070"(SA node cell to atrial cardiac muscle cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901021"(positive regulation of calcium ion transmembrane transporter activity)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR040745|mint:Q01484|rcsb pdb:4D8O|rcsb pdb:4RLV|rcsb pdb:4RLY|rcsb pdb:5Y4D|rcsb pdb:5Y4E|rcsb pdb:5Y4F|rcsb pdb:5YIR|rcsb pdb:5YIS|rcsb pdb:6KZJ|rcsb pdb:6M3Q|reactome:R-HSA-445095|reactome:R-HSA-6807878	intact:EBI-9008940(isoform-parent)|ensembl:ENSG00000006071(gene)|ensembl:ENST00000389817(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:wHoFDw3CIP2xOUZj9WzEMGm/z8k9606	rogid:IZRAMEjIYb2g9tyhdMfSRSNynb09606	rigid:INJcSqwnxFrp/49nf7dI9RDv1uU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14654	uniprotkb:Q09428-1	intact:EBI-2866553|uniprotkb:Q58EX3|uniprotkb:Q2M1H7|uniprotkb:B4DWI4|uniprotkb:E9PNK0|uniprotkb:Q8IW96|ensembl:ENSP00000345708|ensembl:ENSP00000434755	intact:EBI-15807650|ensembl:ENSP00000374467	psi-mi:kcj11_human(display_long)|uniprotkb:KCNJ11(gene name)|psi-mi:KCNJ11(display_short)|uniprotkb:IKATP(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym)	psi-mi:q09428-1(display_long)|uniprotkb:ABCC8(gene name)|psi-mi:ABCC8(display_short)|uniprotkb:HRINS(gene name synonym)|uniprotkb:SUR(gene name synonym)|uniprotkb:SUR1(gene name synonym)|uniprotkb:Sulfonylurea receptor 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kline et al. (2009)	pubmed:19805355|doi:10.1073/pnas.0907138106|imex:IM-15254	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15807660|imex:IM-15254-10|dip:DIP-185779E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001159762.1|dip:DIP-58643N|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|rcsb pdb:6C3O|rcsb pdb:6C3P|reactome:R-HSA-1296025|reactome:R-HSA-382556|reactome:R-HSA-422356|reactome:R-HSA-5578775|reactome:R-HSA-5678420|reactome:R-HSA-5683177|ensembl:ENST00000339994(transcript)|ensembl:ENST00000528731(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0014704"(intercalated disc)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033198"(response to ATP)|go:"GO:0033574"(response to testosterone)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050877"(nervous system process)|go:"GO:0070852"(cell body fiber)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098662"(inorganic cation transmembrane transport)|ensembl:ENSG00000187486(gene)	intact:EBI-9008940(isoform-parent)|ensembl:ENSG00000006071(gene)|ensembl:ENST00000389817(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:EgyckzNz0VCMnwzK/U9vz8J2auk9606	rogid:IZRAMEjIYb2g9tyhdMfSRSNynb09606	rigid:sl5EBWuzIp+RFmiwoNVErm8olpE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q61743	uniprotkb:Q8C8R3	intact:EBI-8603527|ensembl:ENSMUSP00000147439|intact:MINT-2982880|uniprotkb:Q9QX21	intact:EBI-774322|intact:EBI-2133064|uniprotkb:Q6PCN2|uniprotkb:Q3TM62|uniprotkb:Q3V2X0|uniprotkb:Q80ZZ7|uniprotkb:Q8BNC1|uniprotkb:Q8C445|uniprotkb:Q8CCV0|intact:EBI-2255612|intact:EBI-8314005|intact:MINT-4115219	psi-mi:kcj11_mouse(display_long)|uniprotkb:Kcnj11(gene name)|psi-mi:Kcnj11(display_short)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym)	psi-mi:ank2_mouse(display_long)|uniprotkb:Brain ankyrin(gene name synonym)|uniprotkb:AnkB(gene name synonym)|uniprotkb:Ank2(gene name)|psi-mi:Ank2(display_short)|uniprotkb:Ankyrin-B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kline et al. (2009)	pubmed:19805355|doi:10.1073/pnas.0907138106|imex:IM-15254	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15807716|imex:IM-15254-13|dip:DIP-185781E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000096146(gene)|ensembl:ENSMUST00000211674(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0014704"(intercalated disc)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033198"(response to ATP)|go:"GO:0033574"(response to testosterone)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050877"(nervous system process)|go:"GO:0070852"(cell body fiber)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|mint:Q61743|rcsb pdb:5WUA|rcsb pdb:5YKE|rcsb pdb:5YKF|rcsb pdb:5YKG|rcsb pdb:5YW8|rcsb pdb:5YW9|rcsb pdb:5YWA|rcsb pdb:5YWB|rcsb pdb:5YWC|rcsb pdb:6JB1|reactome:R-MMU-1296025|reactome:R-MMU-382556|reactome:R-MMU-422356|reactome:R-MMU-5578775|refseq:NP_034732.1|dip:DIP-42790N	refseq:NP_001029340.1|refseq:NP_848770.2|dip:DIP-58645N|mint:Q8C8R3|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0008104"(protein localization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0015031"(protein transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031430"(M band)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031672"(A band)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0036371"(protein localization to T-tubule)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086066"(atrial cardiac muscle cell to AV node cell communication)|go:"GO:0086070"(SA node cell to atrial cardiac muscle cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901021"(positive regulation of calcium ion transmembrane transporter activity)|go:"GO:2001257"(regulation of cation channel activity)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR040745	psi-mi:"MI:0465"(dip)	comment:mint|function:This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:YH8BUXfxLJ46b4AxxBmt1RmrNtM10090	rogid:SkB13oxZVcKuMnI8r5ItFIq2pXQ10090	rigid:5dv5XXXbh9/vhPmP36t7JZKzwqo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)