#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P25694 uniprotkb:P36037 intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4 intact:EBI-6017|uniprotkb:D6VWZ0|ensemblfungi:YKL213C psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name) psi-mi:doa1_yeast(display_long)|uniprotkb:YKL213C(locus name)|uniprotkb:DOA1(gene name)|psi-mi:DOA1(display_short)|uniprotkb:UFD3(gene name synonym)|uniprotkb:ZZZ4(gene name synonym)|uniprotkb:Degradation of alpha protein 1(gene name synonym)|uniprotkb:Ubiquitin fusion degradation protein 3(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Zhao et al. (2009) pubmed:19805280|doi:10.1073/pnas.0908321106|imex:IM-14819 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15806428|imex:IM-14819-1|dip:DIP-15075E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725 refseq:NP_012709.1|sgd:S000001696|dip:DIP-6274N|mint:P36037|ensemblfungi:YKL213C(gene)|ensemblfungi:YKL213C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0010008"(endosome membrane)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0034517"(ribophagy)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0140036"(ubiquitin-dependent protein binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013535(PUL)|interpro:IPR015155("PFU (PLAA family ubiquitin binding)")|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR020472|interpro:IPR036322|interpro:IPR038122|rcsb pdb:3GAE|rcsb pdb:3L3F|rcsb pdb:3ODT|rcsb pdb:3PSP|rcsb pdb:3PST|reactome:R-SCE-8951664|reactome:R-SCE-983168 psi-mi:"MI:0465"(dip) crc64:02ADDB9A227614D8 crc64:593B808169283B5F full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292 rogid:LDW5eHy5h0O5as31w32uEH3P4kc559292 rigid:iR3DfW7LOdhXGXWuUZUuGWXdE8Y false binding-associated region:821-835 binding-associated region:464-715|mutation disrupting interaction:541-541|mutation decreasing interaction:669-669|mutation decreasing interaction:578-578 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P25694 uniprotkb:P36037 intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4 intact:EBI-6017|uniprotkb:D6VWZ0|ensemblfungi:YKL213C psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name) psi-mi:doa1_yeast(display_long)|uniprotkb:YKL213C(locus name)|uniprotkb:DOA1(gene name)|psi-mi:DOA1(display_short)|uniprotkb:UFD3(gene name synonym)|uniprotkb:ZZZ4(gene name synonym)|uniprotkb:Degradation of alpha protein 1(gene name synonym)|uniprotkb:Ubiquitin fusion degradation protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhao et al. (2009) pubmed:19805280|doi:10.1073/pnas.0908321106|imex:IM-14819 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15806458|imex:IM-14819-2|dip:DIP-15075E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725 refseq:NP_012709.1|sgd:S000001696|dip:DIP-6274N|mint:P36037|ensemblfungi:YKL213C(gene)|ensemblfungi:YKL213C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0010008"(endosome membrane)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0034517"(ribophagy)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0140036"(ubiquitin-dependent protein binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013535(PUL)|interpro:IPR015155("PFU (PLAA family ubiquitin binding)")|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR020472|interpro:IPR036322|interpro:IPR038122|rcsb pdb:3GAE|rcsb pdb:3L3F|rcsb pdb:3ODT|rcsb pdb:3PSP|rcsb pdb:3PST|reactome:R-SCE-8951664|reactome:R-SCE-983168 psi-mi:"MI:0465"(dip) crc64:02ADDB9A227614D8 crc64:593B808169283B5F full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292 rogid:LDW5eHy5h0O5as31w32uEH3P4kc559292 rigid:iR3DfW7LOdhXGXWuUZUuGWXdE8Y false - mutation disrupting interaction:669-669,541-541|ha tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q01853 uniprotkb:P36037 intact:EBI-80597|ensembl:ENSMUSP00000030164|uniprotkb:Q3TFH9|uniprotkb:Q3TIM2|uniprotkb:Q3TXN9|uniprotkb:Q6PI18|uniprotkb:Q8BSR6|uniprotkb:Q8CEG4 intact:EBI-6017|uniprotkb:D6VWZ0|ensemblfungi:YKL213C psi-mi:tera_mouse(display_long)|uniprotkb:Vcp(gene name)|psi-mi:Vcp(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym) psi-mi:doa1_yeast(display_long)|uniprotkb:YKL213C(locus name)|uniprotkb:DOA1(gene name)|psi-mi:DOA1(display_short)|uniprotkb:UFD3(gene name synonym)|uniprotkb:ZZZ4(gene name synonym)|uniprotkb:Degradation of alpha protein 1(gene name synonym)|uniprotkb:Ubiquitin fusion degradation protein 3(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Zhao et al. (2009) pubmed:19805280|doi:10.1073/pnas.0908321106|imex:IM-14819 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15806481|imex:IM-14819-3|dip:DIP-104058E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:Q01853|rcsb pdb:1E32|rcsb pdb:1R7R|rcsb pdb:1S3S|rcsb pdb:2PJH|rcsb pdb:3CF0|rcsb pdb:3CF1|rcsb pdb:3CF2|rcsb pdb:3CF3|reactome:R-MMU-110320|reactome:R-MMU-3371511|reactome:R-MMU-382556|reactome:R-MMU-532668|reactome:R-MMU-5358346|reactome:R-MMU-5689877|reactome:R-MMU-5689896|reactome:R-MMU-6798695|reactome:R-MMU-8876725|reactome:R-MMU-9013407|ensembl:ENSMUSG00000028452(gene)|ensembl:ENSMUST00000030164(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0019904"(protein domain specific binding)|refseq:NP_033529.3|dip:DIP-29796N refseq:NP_012709.1|sgd:S000001696|dip:DIP-6274N|mint:P36037|ensemblfungi:YKL213C(gene)|ensemblfungi:YKL213C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0010008"(endosome membrane)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0034517"(ribophagy)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0140036"(ubiquitin-dependent protein binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013535(PUL)|interpro:IPR015155("PFU (PLAA family ubiquitin binding)")|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR020472|interpro:IPR036322|interpro:IPR038122|rcsb pdb:3GAE|rcsb pdb:3L3F|rcsb pdb:3ODT|rcsb pdb:3PSP|rcsb pdb:3PST|reactome:R-SCE-8951664|reactome:R-SCE-983168 psi-mi:"MI:0465"(dip) - crc64:593B808169283B5F full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs10090 rogid:LDW5eHy5h0O5as31w32uEH3P4kc559292 rigid:hK51dAx9MsunSl/5YOXs5o+mFD8 false binding-associated region:797-806 binding-associated region:464-715 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q01853 uniprotkb:P36037 intact:EBI-80597|ensembl:ENSMUSP00000030164|uniprotkb:Q3TFH9|uniprotkb:Q3TIM2|uniprotkb:Q3TXN9|uniprotkb:Q6PI18|uniprotkb:Q8BSR6|uniprotkb:Q8CEG4 intact:EBI-6017|uniprotkb:D6VWZ0|ensemblfungi:YKL213C psi-mi:tera_mouse(display_long)|uniprotkb:Vcp(gene name)|psi-mi:Vcp(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym) psi-mi:doa1_yeast(display_long)|uniprotkb:YKL213C(locus name)|uniprotkb:DOA1(gene name)|psi-mi:DOA1(display_short)|uniprotkb:UFD3(gene name synonym)|uniprotkb:ZZZ4(gene name synonym)|uniprotkb:Degradation of alpha protein 1(gene name synonym)|uniprotkb:Ubiquitin fusion degradation protein 3(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Zhao et al. (2009) pubmed:19805280|doi:10.1073/pnas.0908321106|imex:IM-14819 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15806502|imex:IM-14819-4|dip:DIP-104058E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:Q01853|rcsb pdb:1E32|rcsb pdb:1R7R|rcsb pdb:1S3S|rcsb pdb:2PJH|rcsb pdb:3CF0|rcsb pdb:3CF1|rcsb pdb:3CF2|rcsb pdb:3CF3|reactome:R-MMU-110320|reactome:R-MMU-3371511|reactome:R-MMU-382556|reactome:R-MMU-532668|reactome:R-MMU-5358346|reactome:R-MMU-5689877|reactome:R-MMU-5689896|reactome:R-MMU-6798695|reactome:R-MMU-8876725|reactome:R-MMU-9013407|ensembl:ENSMUSG00000028452(gene)|ensembl:ENSMUST00000030164(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0019904"(protein domain specific binding)|refseq:NP_033529.3|dip:DIP-29796N refseq:NP_012709.1|sgd:S000001696|dip:DIP-6274N|mint:P36037|ensemblfungi:YKL213C(gene)|ensemblfungi:YKL213C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0010008"(endosome membrane)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0034517"(ribophagy)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0140036"(ubiquitin-dependent protein binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013535(PUL)|interpro:IPR015155("PFU (PLAA family ubiquitin binding)")|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR020472|interpro:IPR036322|interpro:IPR038122|rcsb pdb:3GAE|rcsb pdb:3L3F|rcsb pdb:3ODT|rcsb pdb:3PSP|rcsb pdb:3PST|reactome:R-SCE-8951664|reactome:R-SCE-983168 psi-mi:"MI:0465"(dip) - crc64:593B808169283B5F full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs10090 rogid:LDW5eHy5h0O5as31w32uEH3P4kc559292 rigid:hK51dAx9MsunSl/5YOXs5o+mFD8 false - binding-associated region:464-715 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)