#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P07996	uniprotkb:P15692	intact:EBI-2530274|uniprotkb:A8K6H4|uniprotkb:B9EGH6|uniprotkb:Q15667|ensembl:ENSP00000260356|uniprotkb:B4E3J7|uniprotkb:Q59E99	intact:EBI-1026643|uniprotkb:O60720|uniprotkb:O75875|uniprotkb:Q074Z4|uniprotkb:Q16889|uniprotkb:Q5UB46|uniprotkb:Q6P0P5|uniprotkb:Q96KJ0|uniprotkb:Q96L82|uniprotkb:Q96NW5|uniprotkb:Q9H1W8|uniprotkb:Q9H1W9|uniprotkb:Q9UH58|uniprotkb:Q9UL23|uniprotkb:B5BU86|ensembl:ENSP00000430479|uniprotkb:H0Y2S8|uniprotkb:H0Y407|uniprotkb:H0Y414|uniprotkb:H0Y462|uniprotkb:H0Y8N2|uniprotkb:H3BLW7	psi-mi:tsp1_human(display_long)|uniprotkb:THBS1(gene name)|psi-mi:THBS1(display_short)|uniprotkb:TSP(gene name synonym)|uniprotkb:TSP1(gene name synonym)|uniprotkb:Glycoprotein G(gene name synonym)	psi-mi:vegfa_human(display_long)|uniprotkb:Vascular permeability factor(gene name synonym)|uniprotkb:VEGFA(gene name)|psi-mi:VEGFA(display_short)|uniprotkb:VEGF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Laklai et al. (2009)	pubmed:19805200|doi:10.1073/pnas.0908674106|imex:IM-14848	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15805699|imex:IM-14848-1|dip:DIP-104162E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137801(gene)|ensembl:ENST00000260356(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002581"(negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007155"(cell adhesion)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030141"(secretory granule)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032570"(response to progesterone)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0008201"(heparin binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033574"(response to testosterone)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070052"(collagen V binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017897|interpro:IPR028499|interpro:IPR028974|interpro:IPR036383|mint:P07996|rcsb pdb:1LSL|rcsb pdb:1UX6|rcsb pdb:1Z78|rcsb pdb:1ZA4|rcsb pdb:2ERF|rcsb pdb:2ES3|rcsb pdb:2OUH|rcsb pdb:2OUJ|rcsb pdb:3R6B|rcsb pdb:5FOE|reactome:R-HSA-114608|reactome:R-HSA-186797|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-5083635|reactome:R-HSA-5173214|reactome:R-HSA-8936459|refseq:NP_003237.2|dip:DIP-1037N	refseq:NP_001020537.2|refseq:NP_001020538.2|refseq:NP_001020539.2|refseq:NP_001020540.2|refseq:NP_001020541.2|refseq:NP_001028928.1|refseq:NP_001165093.1|refseq:NP_001165094.1|refseq:NP_001165095.1|refseq:NP_001165096.1|refseq:NP_001165097.1|refseq:NP_001165098.1|refseq:NP_001165099.1|refseq:NP_001165100.1|refseq:NP_001165101.1|refseq:NP_001191313.1|refseq:NP_001191314.1|refseq:NP_003367.4|refseq:NP_001303939.1|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060754"(positive regulation of mast cell chemotaxis)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061042"(vascular wound healing)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|ensembl:ENSG00000112715(gene)|ensembl:ENST00000523873(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0005125"(cytokine activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0007498"(mesoderm development)|go:"GO:0007595"(lactation)|go:"GO:0008083"(growth factor activity)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002575"(basophil chemotaxis)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0010749"(regulation of nitric oxide mediated signal transduction)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030141"(secretory granule)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031077"(post-embryonic camera-type eye development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035148"(tube formation)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036303"(lymph vessel morphogenesis)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0038091"(positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway)|go:"GO:0038190"(VEGF-activated neuropilin signaling pathway)|go:"GO:0038191"(neuropilin binding)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0031012"(extracellular matrix)|go:"GO:1903572"(positive regulation of protein kinase D signaling)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000072("Platelet-derived growth factor (PDGF)")|interpro:IPR023581|interpro:IPR027928|interpro:IPR029034|interpro:IPR036841|mint:P15692|rcsb pdb:1BJ1|go:"GO:1903392"(negative regulation of adherens junction organization)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090259"(regulation of retinal ganglion cell axon guidance)|go:"GO:0097475"(motor neuron migration)|go:"GO:0097533"(cellular stress response to acid chemical)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902336"(positive regulation of retinal ganglion cell axon guidance)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903141"(negative regulation of establishment of endothelial barrier)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|rcsb pdb:1FLT|rcsb pdb:1KAT|rcsb pdb:1KMX|rcsb pdb:1MJV|rcsb pdb:1MKG|rcsb pdb:1MKK|rcsb pdb:1QTY|rcsb pdb:1TZH|rcsb pdb:1TZI|rcsb pdb:1VGH|rcsb pdb:1VPF|rcsb pdb:1VPP|rcsb pdb:2FJG|rcsb pdb:2FJH|rcsb pdb:2QR0|rcsb pdb:2VGH|rcsb pdb:2VPF|rcsb pdb:3BDY|rcsb pdb:3P9W|rcsb pdb:3QTK|rcsb pdb:3S1B|rcsb pdb:3S1K|rcsb pdb:3V2A|rcsb pdb:4DEQ|rcsb pdb:4GLN|rcsb pdb:4GLS|rcsb pdb:4KZN|rcsb pdb:4QAF|rcsb pdb:4WPB|rcsb pdb:4ZFF|rcsb pdb:5DN2|rcsb pdb:5FV1|rcsb pdb:5FV2|rcsb pdb:5HHC|rcsb pdb:5HHD|rcsb pdb:5O4E|rcsb pdb:1CZ8|rcsb pdb:5T89|rcsb pdb:6BFT|rcsb pdb:6D3O|rcsb pdb:6T9D|rcsb pdb:6V7K|rcsb pdb:6Z13|rcsb pdb:6Z3F|rcsb pdb:6ZBR|rcsb pdb:6ZCD|rcsb pdb:6ZFL|rcsb pdb:7LL9|reactome:R-HSA-114608|reactome:R-HSA-1234158|reactome:R-HSA-194138|reactome:R-HSA-194313|reactome:R-HSA-195399|reactome:R-HSA-4420097|reactome:R-HSA-5218921|reactome:R-HSA-6785807|reactome:R-HSA-8866910|reactome:R-HSA-9679191|rcsb pdb:7LL8|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043183"(vascular endothelial growth factor receptor 1 binding)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0042462"(eye photoreceptor cell development)|refseq:NP_001273973.1|dip:DIP-5740N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:wqgWk4yWvhfEjrD+H6BdJrJgVgg9606	rogid:O5iw4Qx7W34QAg3oFkltpRxDYwA9606	rigid:0HDEc/8YGQyM6JExRj4js7BuOUU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)