#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8TEY7	uniprotkb:O55005	intact:EBI-719283|uniprotkb:Q8TEY6|uniprotkb:Q96AV6|uniprotkb:Q9H9F0|uniprotkb:Q9UPQ5|ensembl:ENSP00000350009|ensembl:ENSP00000359829	intact:EBI-3505237	psi-mi:ubp33_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 33(gene name synonym)|uniprotkb:Deubiquitinating enzyme 33(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 1(gene name synonym)|uniprotkb:USP33(gene name)|psi-mi:USP33(display_short)|uniprotkb:KIAA1097(gene name synonym)|uniprotkb:VDU1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 33(gene name synonym)	psi-mi:robo1_rat(display_long)|uniprotkb:Robo1(gene name)|psi-mi:Robo1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yuasa-Kawada et al. (2009)	pubmed:19706539|doi:10.1073/pnas.0801262106|imex:IM-14795	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15801403|imex:IM-14795-1|dip:DIP-104012E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055832.3|refseq:NP_963918.1|refseq:NP_963920.1|ensembl:ENSG00000077254(gene)|ensembl:ENST00000357428(transcript)|ensembl:ENST00000370793(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007411"(axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0044297"(cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q8TEY7|rcsb pdb:2UZG|reactome:R-HSA-5689880|reactome:R-HSA-9010553|go:"GO:0032092"(positive regulation of protein binding)|dip:DIP-48942N	rgd:61941|refseq:NP_071524.1|go:"GO:0001822"(kidney development)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0021510"(spinal cord development)|go:"GO:0021836"(chemorepulsion involved in postnatal olfactory bulb interneuron migration)|go:"GO:0021891"(olfactory bulb interneuron development)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030673"(axolemma)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032986|interpro:IPR036116|interpro:IPR036179|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0035481"(positive regulation of Notch signaling pathway involved in heart induction)|go:"GO:0035904"(aorta development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050925"(negative regulation of negative chemotaxis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0070100"(negative regulation of chemokine-mediated signaling pathway)|go:"GO:1900748"(positive regulation of vascular endothelial growth factor signaling pathway)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|dip:DIP-48941N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:x7/WErmM96OiTTqOz77Np53z1IE9606	rogid:FZnGpdSe5bamCw6zwkkmzOI6d1s10116	rigid:bjMU1CQQsQpDo4UQu5WkdUnTFX8	false	green fluorescent protein tag:n-n	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y6N7	uniprotkb:Q8TEY7	intact:EBI-399762|uniprotkb:Q7Z300|uniprotkb:Q9BUS7|uniprotkb:D3DU36|uniprotkb:B2RXI1|uniprotkb:E9PD49|uniprotkb:Q1RMC7|ensembl:ENSP00000420321	intact:EBI-719283|uniprotkb:Q8TEY6|uniprotkb:Q96AV6|uniprotkb:Q9H9F0|uniprotkb:Q9UPQ5|ensembl:ENSP00000350009|ensembl:ENSP00000359829	psi-mi:robo1_human(display_long)|uniprotkb:ROBO1(gene name)|psi-mi:ROBO1(display_short)|uniprotkb:DUTT1(gene name synonym)|uniprotkb:H-Robo-1(gene name synonym)|uniprotkb:Deleted in U twenty twenty(gene name synonym)	psi-mi:ubp33_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 33(gene name synonym)|uniprotkb:Deubiquitinating enzyme 33(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 1(gene name synonym)|uniprotkb:USP33(gene name)|psi-mi:USP33(display_short)|uniprotkb:KIAA1097(gene name synonym)|uniprotkb:VDU1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 33(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yuasa-Kawada et al. (2009)	pubmed:19706539|doi:10.1073/pnas.0801262106|imex:IM-14795	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15801424|imex:IM-14795-2|dip:DIP-104013E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139317.1|refseq:NP_002932.1|refseq:NP_598334.2|ensembl:ENSP00000420321|ensembl:ENST00000467549|ensembl:ENSP00000417992|ensembl:ENST00000495273|ensembl:ENSP00000420637|refseq:XP_006713340.1|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0021836"(chemorepulsion involved in postnatal olfactory bulb interneuron migration)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0035481"(positive regulation of Notch signaling pathway involved in heart induction)|go:"GO:0035904"(aorta development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050925"(negative regulation of negative chemotaxis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0070100"(negative regulation of chemokine-mediated signaling pathway)|go:"GO:1900748"(positive regulation of vascular endothelial growth factor signaling pathway)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032986|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2EO9|rcsb pdb:2V9Q|rcsb pdb:2V9R|rcsb pdb:2V9T|rcsb pdb:3WIH|rcsb pdb:4HLJ|rcsb pdb:5O5G|rcsb pdb:5O5I|rcsb pdb:5OPE|rcsb pdb:6A77|rcsb pdb:6A78|ensembl:ENSG00000169855(gene)|ensembl:ENST00000464233(transcript)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007399"(nervous system development)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0009986"(cell surface)|refseq:XP_016862472.1|dip:DIP-33034N|rcsb pdb:6A79|reactome:R-HSA-373752|reactome:R-HSA-376176|reactome:R-HSA-428540|reactome:R-HSA-428542|reactome:R-HSA-428543|reactome:R-HSA-428890|reactome:R-HSA-8985586|reactome:R-HSA-8985801|reactome:R-HSA-9010553	refseq:NP_055832.3|refseq:NP_963918.1|refseq:NP_963920.1|ensembl:ENSG00000077254(gene)|ensembl:ENST00000357428(transcript)|ensembl:ENST00000370793(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007411"(axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0044297"(cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q8TEY7|rcsb pdb:2UZG|reactome:R-HSA-5689880|reactome:R-HSA-9010553|go:"GO:0032092"(positive regulation of protein binding)|dip:DIP-48942N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:LLHEVlylzhWB/zr77pQrNizgVsg9606	rogid:x7/WErmM96OiTTqOz77Np53z1IE9606	rigid:VYdr+cQo/bmdcsXupkMqOy1cGXk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)